The Hungarian Prison Service Headquarters (BvOP) announced on Tuesday that prisoners are producing metal and wooden furnishings for the new prison being built in Csenger Head of the Communication Department Colonel György Makula stated that alongside innovative IT developments the cell equipment will also be most modern in the new prison Production is in full swing at the Sopronkőhida Ironworks and the Budapest Carpentry Workshop of the Prison Service which are being executed in collaboration with Duna Mix Ltd all metal furnishings are being manufactured at Sopronkőhida Ironworks He added: ‘The metal cell furnishings will be entirely different from the previously standardized ones and chairs will be wall-mountable to prevent vandalism and the hiding of unauthorized items.’ Colonel Makula also mentioned that the self-designed cell fixtures will be produced in four different colours and modern painting will be done at the company’s powder coating facility established in 2022 as an in-house investment This facility employs 26 inmates serving their sentences at the Sopronkőhida Prison he explained that within a month and a half 850 pieces of furniture will be produced by inmates at the Budapest site of Nagyfa – Alföld Ltd He highlighted that applications are still open for various positions at the new Csenger prison So-called smart prisons have been built worldwide since 2018, State Secretary Bence Rétvári explained in January noting that digital elements are already present in Hungarian prisons and administrative processes are conducted using such tools the Csenger prison will feature technology that allows full control over the movements of inmates analysing their behaviour and facial expressions with the help of artificial intelligence the system sends an alert to the supervisors to prepare for any extraordinary events This will further enhance the safety of incarceration Hungarian Conservative is a quarterly magazine on contemporary political philosophical and cultural issues from a conservative perspective Metrics details propagates and exacerbates cardiovascular diseases via various mechanisms that are yet not properly understood Extracellular vesicles (EVs) are involved in the pathomechanism of these diseases To understand how circulating or cardiac-derived EVs could affect myocardial functions we analyzed the metabolomic profile of circulating EVs and we performed an in-depth analysis of cardiomyocyte (CM)-derived EVs in HC Circulating EVs were isolated with Vezics technology from male Wistar rats fed with high-cholesterol or control chow AC16 human CMs were treated with Remembrane HC supplement and EVs were isolated from cell culture supernatant The biophysical properties and the protein composition of CM EVs were analyzed THP1-ASC-GFP cells were treated with CM EVs HC diet reduced the amount of certain phosphatidylcholines in circulating EVs HC treatment significantly increased EV secretion of CMs and greatly modified CM EV proteome enriching several proteins involved in tissue remodeling CM EVs did not induce the activation of THP1 monocytes HC strongly affects the metabolome of circulating EVs and dysregulates CM EVs which might contribute to HC-induced cardiac derangements These results suggest that EVs play a role in CVDs and HC how HC affects the metabolic profile of circulating EVs has not been assessed so far CMs are the main constituent and the functional element of the myocardium Their EV-mediated regulation of the cardiac milieu might have great importance in CVDs the effect of HC on EVs released by CMs still needs to be addressed to understand the connection between CMDs and HC an in-depth analysis of CM EVs is necessary These results suggest that CM EVs might play a role in HC-induced inflammation To fill the gaps and to extend our knowledge on the effect of HC on both systemic and cardiac EVs we aimed to identify the metabolic alterations in circulating EVs and to analyze CM EVs in HC we isolated rat circulating EVs and compared their metabolomic changes to their plasma metabolome we assessed how HC affects the biophysical and biochemical properties of CM EVs and we analyzed their role in the activation of monocytes Metabolomic analysis of circulating EVs in HC-fed rats nhc = 7 for all experiments) (A) Schematic representation of the experimental plans Male Wistar rats were kept on normal or HC diet for 12 weeks then blood was collected and EVs were isolated from platelet-free plasma (C) HC diet increased the amount of cholesterol esters in the blood (D) Volcano plot of metabolome analysis on plasma (left) and EVs (right) the intensity of numerous triacylglycerols was significantly reduced meanwhile glycerophospholipids and cholesterol esters were enriched by HC the intensity of most glycerophospholipids detected was decreased by HC (E) Heatmap for the metabolites detected both in EVs and in plasma Multiple metabolites show opposite changes between EVs and plasma (F) Linear correlation of multiple metabolites in EVs vs only glycerophospholipids showed a moderate correlation between plasma and EV intensities (see regression line *p < 0.05 Student’s t-test CTRL vs HC; For metabolomics analysis (panel E) Benjamini–Hochberg false discovery p-adjustment was applied This analysis evidence that HC diet modulates metabolites in EVs and plasma differentially (A) Schematic representation of the experimental plans and then the medium was replaced with serum-free medium with or without vehicle or HC supplement for another 48 h then EVs were isolated from the cell culture supernatant (B) Representative images of oil-red-o measurements on AC16 cells Results show increased amounts of lipids upon HC treatment (C) Size distribution of isolated EVs measured by NTA Vesicles with diameters of 50–300 nm were detected in every experimental group nhc = 10) (D) Particle number of EV isolates measured by NTA HC increased the particle number significantly nhc = 10) (E) Absolute protein concentration of the isolates measured with 280 nm light absorbance HC increased the protein concentration significantly nhc = 14) (F) Analysis of EV markers and potential contaminants using Western blot Whole blots are presented in Supplementary Figure S3 (G) Elastic modulus of the isolates measured by AFM out of at least three independent experiments) (H) Representative images of non-contact mode AFM measurements second row: amplitude-contrast images in the same view field *p < 0.05 HC vs CTRL and VEH in ANOVA with Tukey’s post-hoc test These results confirm the EV origin of our membrane particles and that they might contain a certain level of non-EV material HC does not affect the lipid composition of CM-derived EVs Analysis of immune cell activation of AC16 EVs using THP1-ASC-GFP (A) Schematic representation of the experimental setup EVs were isolated from AC16 cells and THP1-ASC-GFP cells were treated with the isolates then flow cytometry measurement was applied to measure GFP expression and protein expression was analyzed with qPCR (B) GFP expression measured by flow cytometry LPS significantly increased the percentage of activated cells EV treatment did not affect GFP expression regardless of the dose or the experimental group (n = 6 No differences were observed (n = 2–3) *p < 0.05 vs PBS; ANOVA with Tukey’s post-hoc test in all experiments) (A) Comparison of the proteins detected with the Vesiclepedia database A total of 2137 proteins were identified of which 2088 were described in the database and 84 proteins were found among the 100 most frequently described EV proteins (B) Venn diagram for the representation of the statistically significant differences between the experimental groups using ANOVA followed by Turkey’s post-hoc test (C) Volcano plot shows significant differences between the VEH and HC groups (D) Interaction network of proteins with significantly different abundance between the VEH and HC groups which were selected for further analysis to explore proteomic changes induced by HC treatment in CM-derived EVs our data show that HC treatment substantially affects the proteomic composition of CM EVs Enrichment in RNA-associated proteins suggests that the RNA cargo of EVs can be modified as well no specific cellular signalization pathway was identified that would be directly connected to HC-induced cardiomyopathy we aimed to get a deeper insight into the impact of HC on circulating and CM EVs We showed that HC diet reduced the amount of certain PCs in EVs and that changes in the lipid composition of the blood and EVs showed strikingly different patterns we showed that HC treatment altered both the quantity and protein composition of EVs from CMs we show that HC does not affect THP-1 monocyte activation and that we identified an opposite directional change in lipoprotein-rich plasma supports that the PC amount of the EV membrane or EV-associated extravesicular constituents was decreased and such change is regulated independently of that of the plasma a more sensitive analysis of possible non-vesicular proteins such as mass spectrometry could be implemented As little is known about how the reduction of PCs affects EV-regulated mechanisms functional experiments and comprehensive analysis of circulating EVs in HC including how such EVs affect a healthy organism also need to be implemented metabolic analysis of EVs may provide pathophysiological or diagnostic information on cardiometabolic derangements that might remain shrouded if plasma analysis was performed alone our results together with previous findings show that cholesterol affects EV secretion through multiple mechanisms these changes in the CM EV proteome may play a role in HC-induced cardiac remodeling these changes might aim to alleviate dyslipidemia and indicate the stressed metabolic condition of the CMs complete 40S ribosomal subunits are presumably released in HC EVs as the amount of most of its proteins was increased the relevance of these changes needs further elucidation our results indicate that HC treatment has a diverse effect on the molecular composition of CM EVs these changes outline a stress signal of the CMs propagated by EVs To validate the suggested functional effects and to unravel whether these changes contribute to or compensate for HC-induced cardiac abnormalities further functional experiments will need to be performed This contradiction indicates that CM- and circulating EVs might have opposing effects in the context of inflammation in HC we concluded that CM EVs do not contribute to monocyte activation via inflammasome activation further experiments may provide additional insights into the role of CM EVs in inflammation As we found that the amount of certain PCs was decreased in circulating EVs we have analyzed the total PC content of CM EVs the PC concentration in CM EVs was unchanged the lipid to protein ratio and the membrane rigidity a complete comparison of the two EV sources including both metabolomics on CM EVs and proteomics on circulating EVs may result in correlations between the sources our results suggest that CM EVs are regulated differently in HC than circulating EVs here we broadened our knowledge of how HC alters the molecular composition of circulating EVs and thoroughly analyzed its effect on CM EVs According to our results and earlier studies EVs from both sources display a stressed condition these EVs might contribute to the dysregulated cardiac homeostasis and tissue remodeling in HC Further analysis of these EV-mediated pathophysiological mechanisms may improve our understanding of the interaction between cardiovascular and metabolic diseases Vezics system (vezics.com) was used to implement the isolation Metabolites were excluded from the analysis if less than half of the measurements (< 7 for CTRL and < 4 for VEH) were below the limit of detection (LOD) in both groups independently for EV and plasma samples values below the LOD were imputed with a normal distribution around half of the LOD metabolite types for which at least twelve plasma-EV measurement pairs were available were analyzed with a linear regression model For both linear regression and statistical analysis cells were trypsinized and cell count was measured using a hemocytometer and viability was determined by Trypan blue (Cytiva Cells were used only if viability reached 90% AC16 cells were seeded on CELLview cell culture microscope slides (Greiner Bio-One Austria) at a concentration of 20,000 cells/well the cells were treated with HC treatment solution then cultured for another 48 h at 37 °C in a CO2 incubator The cells were fixed in 10% neutrally buffered formalin washed with ultrapure water and then with 60% isopropanol The cells were then stained with Oil Red O solution (3 mg/mL) (Sigma This was followed by another wash with isopropanol followed by ultrapure water and the nuclei were labeled with 1:1.000 dilution of DAPI (Cell Signaling Technologies and the samples were covered with Prolong Gold (Thermo Scientific USA) mounting medium and coverslips were applied Samples were examined with a Leica SP8 confocal microscope Oil-Red-O dye was excited at 552 nm and the emitted fluorescence was detected in the range of 645–767 nm A total of 3.5 million AC16 cells were seeded in 175 cm2 culture dishes and 24 h later the culture medium was changed to FBS-free medium the culturing medium was collected in 50 mL centrifuge tubes and EVs were isolated using differential centrifugation Cell supernatants were centrifuged at 300 × g at 4 °C for 10 min (Hettich Universal 320R; Rotor type: 1494 with Hettich 1427 adaptor) Then supernatants were centrifuged at 2,500 × g at 4 °C for 5 min (Hettich Universal 320R; Rotor type: 1494 with Hettich 1427 adaptor) The supernatants were transferred into 50 mL centrifuge tubes (Herolab Cat no.: 253211) and centrifuged at 13,500 × g at 4 °C for 40 min (Hermle Z326K; Rotor type: 220.78 V20.) they were transferred into ultracentrifuge tubes (Beckman Coulter no.: 326823) and centrifuged at 174,900 × g at 4 °C for 3 h using an ultracentrifuge (Optima XPN-100; Rotor type: SW32Ti with adaptor 129.7) Pellets were resuspended in 120 µL phosphate-buffered saline (PBS) or 120 µL Tris-buffered saline (TBS) for atomic force microscopy (AFM) Protein concentration was measured with light absorbance at 280 nm by Implen N50 (Implen EV samples were analyzed by Zeta View PMX 110 (Particle Metrix Germany) nanoparticle tracking analysis (NTA) machine calibrated with 100 nm polystyrene beads according to the manufacturer’s protocol Samples were diluted in PBS to a concentration of 50–300 particles in a view of sight At least 1 mL of sample was injected into the machine and automated measurements were performed at 11 positions throughout the measurement cell Positions for which the software recommended exclusion were excluded from the final evaluation Instrument parameters were set as: temperature 25 °C frame rate 30 frames per second and shutter speed 100 Post-acquisition parameters were set as: minimum brightness 20 minimum size 5 pixels and maximum size 1000 pixels Results were multiplied by the dilution factor the mean of all the measurements was calculated data were smoothed with Loess regression and visualized with ± SEM EV samples were lysed in radioimmunoprecipitation assay buffer (Cell Signaling Technologies USA) supplemented with 1 mM of PMSF (Roche and complete protease inhibitor cocktail (Roche Equal volumes of each sample were mixed with 1/4 volume of Laemmli buffer containing β-mercaptoethanol (Thermo Scientific USA) and loaded on Tris–glycine sodium dodecyl sulfate–polyacrylamide gels (Bio-Rad Proteins were transferred onto a PVDF membrane (Bio-Rad Membranes were blocked in 5% bovine serum albumin (Bio-Rad USA) in Tris-buffered saline containing 0.05% Tween-20 at room temperature for 2 h Primary antibodies used were anti-TSG101 (ab83 The presence of individual contaminating organelles was detected using the Organelle Detection Western Blot Cocktail (ab133989 The cocktail contained anti-sodium–potassium ATPase (plasma membrane) anti-GAPDH (cytosol) and anti-Histone-H3 (nucleus) antibodies USA) secondary antibodies were used to detect the proteins Signals were visualized using enhanced chemiluminescence kit (Bio-Rad USA) and analyzed with Image Lab software (Bio-Rad Lipid content was determined as described previously by Visnovitz et al.76 W310727) was dissolved in 50 mL of 17% phosphoric acid (Sigma 79617) to create phosphor-vanillin reagent 200 µL of 96% sulfuric acid was added either to 40 µL of 1,2-Dioleoyl-sn-glycero-3-phosphocoline (DOPC) (Sigma or to 40 µL of EVs suspended in sterile filtered PBS samples and standards were incubated at 90 °C in a fume hood for 20 min Tubes were cooled down and 120 µL of phospho-vanillin reagent was added to each tube and 280 µL of each sample was transferred into a 96-well plate and was incubated at 37 °C for 1 h Absorbance was determined at 540 nm using a plate reader (Multiskan Go Total PC content was measured using a colorimetric assay (CS0001 at 0.5–1 Hz line scanning frequency in buffer oscillating the cantilever at its resonance frequency Contact mode measurements were then performed for in situ force spectroscopy on selected spherical vesicles with topographical height exceeding 15 nm the cantilever was moved at speed of 1 µm/s from a pre-set height towards the vesicle until a load threshold of 100 pN was reached It was then immediately retracted at the same speed Deflection of the cantilever and thus force as a function of cantilever position (force-indentation curve or force curve) were recorded during the process THP1 human monocytes expressing apoptosis-associated speck-like protein containing a CARD domain fused by green fluorescent protein (ASC-GFP France) were maintained in THP1 medium consisting of RPMI 1640 medium (Gibco 15,-630-080) at a maximum of 6 × 105 cells/mL in a T175 flask THP1 medium was also supplemented with 100 μg/mL Zeocin (InvivoGen ant-zn-0.5) for transgene selection at every second passage All experiments were performed within 10 passages and repeated at least four times 1 × 106 THP1-ASC-GFP cells in 24-well plates were treated with either 100 ng/mL LPS and then cells were collected onto ice for flow cytometry analyses Cells were resuspended in PBS and fixed with 1% PFA at 4 °C for 10 min and washed twice Flow cytometry was performed using BD FACSCalibur (BD Biosciences USA) and evaluated using Flowing software (Turku Bioscience THP1-ASC-GFP cells were gated first on live cells based on SSC and FSC followed by GFP+ population analysis using Hypoxanthine Phosphoribosyltransferase 1 (HPRT) as a housekeeping gene Data are presented as mean ± standard error of the mean All procedures were approved by the National Scientific Ethical Committee on Animal Experimentation and the Semmelweis University’s Institutional Animal Care and Use Committee (H-1089 Budapest Hungary) in 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R Foundation for Statistical Computing, (Vienna, Austria, 2022). https://www.R-project.org/ A comorbidity model of myocardial ischemia/reperfusion injury and hypercholesterolemia in rat cardiac myocyte cultures An improved 96 well plate format lipid quantification assay for standardisation of experiments with extracellular vesicles Calibration of atomic-force microscope tips A review of the biomechanical properties of single extracellular vesicles A novel LC system embeds analytes in pre-formed gradients for rapid Online parallel accumulation–serial fragmentation (PASEF) with a novel trapped ion mobility mass spectrometer The PRIDE database resources in 2022: A hub for mass spectrometry-based proteomics evidences MaxQuant enables high peptide identification rates individualized p.p.b.-range mass accuracies and proteome-wide protein quantification Accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction String: A web-server to retrieve and display the repeatedly occurring neighbourhood of a gene The STRING database in 2023: Protein–protein association networks and functional enrichment analyses for any sequenced genome of interest Helium conditioning increases cardiac fibroblast migration which effect is not propagated via soluble factors or extracellular vesicles Analyzing real-time PCR data by the comparative CT method ggplot2: Elegant Graphics for Data Analysis (Springer-Verlag Download references We thank Barna Vásárhelyi for his contribution in our project and to interpret our results with his expertise opinions We thank the Department of Languages for Specific Purposes of Semmelweis University for their language editing Tímea Katinka Halászi and Tünde Petrovics for their devoted work Open access funding provided by Semmelweis University This research was funded by the National Research Development and Innovation Office of Hungary (NKFIA NVKP-16-1-2016-0017 National Heart Program Development and Innovation fund TKP2021-EGA-23 Thematic Excellence Program 2020-4.1.1.-TKP2020) and by the European Union (RRF-2.3.1-21-2022-00003 Horizon2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No 101007931) Development and Innovation Office (NKFIH) of Hungary (K139105) were supported by the Semmelweis 250 + Excellence PhD Scholarship (EFOP-3.6.3-VEKOP-16-2017-00009) was supported by the Gedeon Richter Excellence PhD Scholarship was further supported by the ÚNKP-23-3-II-SE-42 and New National Excellence Program of the Ministry for culture and innovation from the source of the National research was supported by the SFI Comprehensive Molecular Analytical Platform (CMAP) (18/RI/5702) These authors contributed equally: Csenger Kovácsházi and Szabolcs Hambalkó Department of Pharmacology and Pharmacotherapy ELKH-SE Translational Extracellular Vesicle Research Group HCEMM-SU Extracellular Vesicle Research Group Department of Biophysics and Radiation Biology Laboratory of Mass Spectrometry and Separation Technology Systems Biology Ireland and School of Medicine UCD Conway Institute of Biomolecular and Biomedical Research HUNREN-SE Biophysical Virology Research Group CK and SH were the principal investigators of the study CP and PF took part in the conceptualization CP and DK were responsible for the preparation of AC16 materials RF and GBK coordinated and performed metabolomics NK and MK set up the methodology of AFM measurements BYW and ALH performed monocyte activation experiments with the coordination of SH KW performed proteomics with the coordination of CK and DM CK and DK performed formal analysis and data visualization All authors read and approved the final manuscript and ZG is the Translational Program Director of Pharmahungary Group EIB is member of the Advisory Board of Sphere Gene Therapeutics Inc USA) and the Scientific Advisory Board of ReNeuron (UK) All other authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-024-62689-6 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology Looking to access paid articles across multiple policy topics Interested in policy insights for EU professional organisations There’s no mistaking his Fidesz credentials. Brussels needs to back off, and refugees remain unwelcome, Zsolt Csenger-Zalán, the chairman of the Committee on Foreign Affairs in Hungary‘s National Assembly, told EURACTIV Czech Republic Zsolt Csenger-Zalán [Zsolt Csenger-Zalán/Facebook] Slovakia and Hungary) adopted yesterday (2 March) a joint statement on their input to the Rome Declaration which will be adopted at the summit in the Italian capital on 25 March The emergence of multi-speed Europe is particularly undesirable for them Slovakia and Poland (the Visegrád Four) rejected yesterday (28 March) what they called Brussels' use of "blackmail and diktat" over planned resettlements of migrants across the EU This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Central Europe’s most advanced prison is under construction in Csenger equipped with a high-tech smart prison system including video analysis and location determination Interior Ministry State Secretary Bence Rétvári stated at a press conference in Budapest on Friday the Parliamentary State Secretary for the National Prison Service emphasized at the headquarters of the Hungarian Prison Service (BVOP) that Hungary is among the world’s twenty safest countries the number of inmates has increased by five thousand while the annual number of crimes committed has decreased by 280 thousand The new Criminal Code is one of the strictest in Europe leading to more criminals being sentenced to prison for longer periods of time and the new facility in Csenger is another important step towards ensuring the safety and security of the Hungarian people The location of the new prison has been selected bearing in mind that it will generate will create approximately seven hundred jobs in Szabolcs-Szatmár-Bereg County one of the less developed regions of the country The recruitment of prison guards is already underway So-called smart prisons have been built worldwide since 2018 He added that this will further enhance the safety of incarceration Colonel László Biczó, the project manager of the construction, reported that over fifteen hundred resumes have been received so far, and 196 applicants have already been accepted. Currently, 172 are undergoing the 14-week preparatory training. They continue to welcome interested individuals, and applications can be submitted at the Csenger recruitment office or on the BVOP central recruitment page at their website where detailed requirements are also available He highlighted that every cell will have an ‘informational tool,’ allowing the inmate to manage their affairs through a closed online channel and obtain up-to-date information about their data with digital administration wherever possible The Csenger prison is scheduled to be inaugurated on 30 September the prison doors will operate with facial recognition there will be a two-thousand-square-metre workshop A groundbreaking reintegration initiative designed to support prisoners in Hungary has commenced with over 835 participants already preparing for life after incarceration according to a statement by the Ministry of the Interior on Thursday known as the ‘Comprehensive Crime Prevention and Reintegration Programme to Strengthen Social Cohesion’ involves 4,000 prisoners across the country It is funded by a non-repayable European Union grant of 5.658 billion forints and is part of the Human Resources Development Operational Programme Plus framework The initiative focuses on equipping inmates with marketable skills developing competencies needed for employment Additional components include restorative justice programmes and fostering social reintegration to prepare prisoners for a productive life post-release Participants receive personalized guidance to enhance their employability and build a foundation for successful reintegration ‘The programme supports prisoners for up to a year after their release providing follow-up assistance to ensure long-term success’ The programme also aims to reduce reoffending rates and combat social exclusion The initiative offers a suite of services to ease prisoners’ transition back into society Local communities benefit from restorative justice programmes which strengthen inmates’ accountability and commitment to social values the programme supports prisoners for up to a year after their release providing follow-up assistance to ensure long-term success the programme also includes services for inmates’ families to prepare them for the reintegration process and improve their socio-economic standing at least 750 inmates will have the opportunity to acquire marketable qualifications The project also aims to extend services to 300 family members and involve at least 600 individuals in community employment initiatives The Ministry highlighted that similar initiatives such as the 15-year-old ‘Tett (Deed) Programme’ have laid the foundation for this comprehensive reintegration effort Implemented in partnership with the National Command of Penitentiary Institutions the project builds on this legacy to deliver impactful outcomes The Ministry also invited organizations to participate in restorative justice programmes within prisons emphasizing the need for community support to make such initiatives effective.‘Restorative justice can only succeed with a receptive audience,’ the statement noted The project’s overarching aim is to integrate released prisoners into the workforce and society, thereby fostering a safer and more cohesive community. Further details about the programme can be accessed at bv.gov.hu Csenger-Zalán Zsolt fideszes képviselőt canberrai nagykövetté nevezik ki, emiatt nem indul újra egyéniben Budakeszin, ahol így Szijjártó Péter egyik államtitkára, Menczer Tamás próbálhat szerencsét jövő tavasszal az ellenzéki közös jelölttel, vélhetően Szél Bernadettel szemben, írja a Hvg.hu. Csenger-Zalán harmadszor indulna újra egyéniben A lap szerint Menczer nagyobb eséllyel tudna nyerni Szél Bernadett ellen a felkérés találkozott a személyes karrierelképzeléseivel a karrieremet egy diplomáciai közszolgálattal fejezem be ráadásul Ausztráliában jelentős a magyar diaszpóra – mondta. Menczer nem válaszolt a jelöltségére. A Telexnek néhány hónapja azt nyilatkozta,  de ilyen fontos kérdéssel kapcsolatban a megfelelő időben kell mert a parlamenti választás előtt fél évvel nem szeretne lemondani hogy Mikola Istvánt szintén nagykövetnek nevezték ki ő Pápua Új-Guineában és a Salamon-szigeteken nagykövet most Hungary is constructing a new prison in Csenger and it will have some unexpected new features The current plans for the prison were foreshadowed in a recent press conference by Bence Rétvári Hungary’s current Secretary of State The confrence was held at the National Command of the Prison Service (BVOP) on Friday and revealed some surprising technological upgrades According to Economx Central Europe’s most advanced prison is being built in Csenger This aligns well with the fact that Hungary is one of the top twenty safest countries there was a growth of five thousand inmates and a drastic decrease in the number of crimes He added that this is most likely because the new penal law code is one of the strictest in Europe This means more criminals sentenced to longer prison terms Several other prisons have already gone through an expansion but the Csenger prison puts Hungary to another level of penalty enforcement The prison is said to have a capacity of 1500 and will have a fully operational video analysis and location determining system The Secretary of State added that such prisons are not a new invention since this level of technology has been implemented for prison use since 2018 worldwide they have been experimenting for the last few years with digital elements inside the prison So far they have mostly used it for communication with relatives the easier handling of interrogations and paperwork there will be technology allowing for complete control of the inmates’ movements and artificial intelligence will analyse their behavior and facial expressions If their behaviour shifts from their usual routine the system will send a signal to the supervisors they can prepare for an unusual event in case something out of the ordinary happens The prison doors will operate without keys To ensure the maximal employment of inmates each cell will have a “computer technology device,” allowing the convicted to manage their affairs through a closed online channel This way they can access up-to-date information about their data and there will be digital administration as much as possible,” added the professional project manager The State Secretary also outlined the future of digital penal execution adding that this will make detention even safer Bence Rétvári also emphasised that the choice of location is deliberate The Csenger prison is placed in the Szabolcs-Szatmár-Bereg county region where it will create approximately seven hundred jobs He said the recruitment of prison guards has already begun the professional project manager provided additional details He reported that more than 1500 resumes have been received by the recruiters so far out of which 196 applicants were already accepted where they welcome and train the newcomers for their job there are 172 applicants undergoing training future members of the professional staff may receive cafeteria benefits Those participating in the training will be entitled to full pay from the first day of education The scheduled date for the opening of the Csenger prison is 30 September Unless you are a people smuggler – because then you are released because there is no space for you in our vaunted jails: https://www.aljazeera.com/news/2023/8/23/hungary-releases-over-1400-jailed-people-smugglers and website in this browser for the next time I comment Y"},"category":false,"taxonomy":{"active":false,"name":"category"}},"markup":{"custom_html":true,"wpp-start":"","wpp-end":"<\/ul>","title-start":"","title-end":"<\/h2>","post-html":"{thumb} {title} {stats}<\/span>{excerpt}<\/p><\/li>"},"theme":{"name":""}} You have successfully joined our subscriber list SupportUs Newsletter © 2025 DailyNewsHungary | All rights reserved