Upadacitinib as New Treatment for Giant Cell Arteritis Filling the Gap: Creating a Prognostic Staging System for Patients Treated With Neoadjuvant Chemotherapy RFK Jr.’s Vaccine Policies Spark Alarm Among Public Health Experts Editorial Policy Advertising Contact Us eNewsletters Contribute Career Center MashupMD Blood Cancers Today Cancer Nursing Today GU Oncology Now Urban Health Today Article By: Clark Leonard The University of North Georgia's (UNG) College of Science & Mathematics, in partnership with The Lab Depot, Inc. has launched an innovative program to provide science and mathematics (STEM) students with a valuable job shadowing experience with an emphasis on the development of important business soft skills.  In addition to the Business Leadership and Apprenticeship Development Experience (BLADE) The Lab Depot has committed to a $25,000 donation to support the new STEM building that is planned for UNG's Dahlonega Campus "UNG is proud to partner with The Lab Depot for the BLADE program," Dr. John Leyba dean of the College of Science & Mathematics "They have been a valuable partner and reliable supplier to UNG's lab science courses for many years Their staunch support of UNG is phenomenal."  The Lab Depot Chief Financial Officer Jere Allen is a 1998 UNG alumnus Building on other successful engagements with the university he began looking for a way to provide students with an introduction to an element that is often missing in academics: a live "behind-the-scenes" business experience that is relatable to their career pursuits "We felt like this could be a great bridge between all they have learned in the classroom as they begin the transition to a full-time workplace environment," Allen said The BLADE program gives students experience in a laboratory equipment and supply distribution business Students receive practical information regarding basic business practices for laboratory product sourcing in an e-commerce environment A specific focus is given to observing and analyzing data points in critical areas of the business Beyond these more technical aspects of the company students also participate in mock interviews and receive reviews of their resumes and LinkedIn profiles Each student spends approximately three weeks visiting The Lab Depot once or twice per week to gain insights into different parts of the business "We are in a unique position to support students in realizing the value of their degree It can be scary to not know what you’re going to do after graduation," Susan Csomor a 2016 UNG alumna and The Lab Depot communications and content officer "There is a myriad of jobs inside or outside a lab where students and graduates can apply their scientific or mathematical knowledge."  Mason Jones, a senior from LaGrange, Georgia, pursuing a degree in chemistry but his experience in BLADE has opened his eyes to the business side of chemistry rather than just academia "It's been interesting to see how the company makes sure it's customers are taken care of," Jones said "It's changed my perspective of exactly where I want to go in my career."   Nick Stoltz, a senior from Buford, Georgia, pursuing a degree in biology was grateful for the variety of input he received as the BLADE program's first participant in September.  © 2025 The University System of Georgia and the University of North Georgia UNG follows the section 508 Standards and WCAG 2.1 for web accessibility. If you require this content in another format, please send an email to the ADA Coordinator. Use of military-themed imagery does not constitute endorsement by the U.S we deeply value and uphold the cherished right of every American to freely express themselves As a distinguished Senior Military College we take great pride in our role of cultivating leaders who tirelessly defend these fundamental freedoms for all citizens.  The legacy of our graduates in this regard is second to none our primary responsibility is to cultivate an academic environment that ensures this exchange of ideas and the safety of our community we are committed to fostering a welcoming atmosphere where individuals feel empowered to freely express themselves and engage in exploration and learning it is essential that these rights are exercised in a manner that upholds our academic mission and is in accordance with our institutional policies and other criminal acts will not be tolerated at the University of North Georgia and civility as we equip our students to walk toward their purpose Metrics details Schizophrenia patients exhibit impairments in prepulse inhibition (PPI) of the startle response Hallucinogenic 5-HT2A receptor agonists are used for animal models of schizophrenia because they mimic some symptoms of schizophrenia in humans and induce PPI deficits in animals one report indicates that the 5-HT2A receptor agonist psilocybin increases PPI in healthy humans we investigated these inconsistent results by assessing the dose-dependent effects of psilocybin on PPI in healthy humans Sixteen subjects each received placebo or 115 and 315 μg/kg of psilocybin at 4-week intervals in a randomized and counterbalanced order and 2000-ms interstimulus intervals (ISIs) was measured 90 and 165 min after drug intake coinciding with the peak and post-peak effects of psilocybin The effects of psilocybin on psychopathological core dimensions and sustained attention were assessed by the Altered States of Consciousness Rating Scale (5D-ASC) and the Frankfurt Attention Inventory (FAIR) Psilocybin dose-dependently reduced PPI at short (30 ms) and increased PPI at long (120–2000 ms) ISIs without affecting startle reactivity or habituation Psilocybin dose-dependently impaired sustained attention and increased all 5D-ASC scores with exception of Auditory Alterations psilocybin-induced impairments in sustained attention performance were positively correlated with reduced PPI at the 30 ms ISI and not with the concomitant increases in PPI observed at long ISIs These results confirm the psilocybin-induced increase in PPI at long ISIs and reveal that psilocybin also produces a decrease in PPI at short ISIs that is correlated with impaired attention and consistent with deficient PPI in schizophrenia The aim of the present study was to further investigate the contradictory results on the effect of serotonergic hallucinogens on PPI between animals and humans we measured PPI of ASR in 16 healthy volunteers each under placebo as well as under three different doses of the 5-HT2A/1A agonist psilocybin We applied a startle paradigm that consists of PP combinations ranging from short (30 presumably ‘pre-attentive’ to long ‘attentive’ ISIs (120 Owing to the previous consistent effects of hallucinogens in animals we expected a dose-dependent decrease of PPI in our human volunteers This study was approved by the Ethics Committee of the University Hospital of Psychiatry and the use of psilocybin was authorized by the Swiss Federal Office for Public Health scores two SD above the mean value of normative data in the respective subscales of the FPI (ie openness and neuroticism) were used as exclusion criteria No subjects were excluded using these criteria Some subjects had minimal prior drug experiences (once or twice all more than 6 months prior to the study); all other subjects were drug-naïve and four were light smokers (<6 cigarettes/day) All volunteers gave their written consent after being informed by a written and oral description of the study and the effects and possible risks of psilocybin administration Psilocybin (4-phosphoryloxy-N,N-dimethyltryptamine) was obtained through the Swiss Federal Office of Public Health Berne and prepared as capsules of 1 and 5 mg at the Pharmacy of the Cantonal Hospital of Aarau Psilocybin and lactose placebo were administered in gelatin capsules of identical appearance Sessions were conducted in a calm and comfortable laboratory environment Participants were told to abstain from alcohol the day prior to each session and not to drink caffeine-containing beverages or to eat 2 h prior to each session The four light smokers were told to maintain their usual smoking habits One hour after arriving in the research laboratory subjects received placebo or psilocybin in capsules (0900 h) Startle measures were obtained 90 and 165 min after capsule intake to coincide with the peak and post-peak effects of psilocybin The FAIR task assessing attentional performance were conducted at 0 and 360 min after treatment while the 5D-ASC rating was conducted at about 125 and 200 min after treatment After the acute effects of psilocybin had subsided completely subjects remained in the hospital for another 2 h and were monitored clinically the startle measures examined were: (1) startle reactivity the magnitude of responses on PA trials from block 1–4; (2) %habituation according to the formula (1−(startle magnitude for PA block 1/startle magnitude for PA block 4) × 100; and (3) %PPI according to the formula (1−(mean startle magnitude on PP trials/mean startle magnitude on PA trials × 100) The 5D-ASC questionnaire consists of five scales comprising several item clusters measures derealization and depersonalization accompanied by changes in affect ranging from heightened mood to euphoria and/or exaltation The corresponding item clusters are positive derealization (2) Anxious Ego Dissolution (AED) measures ego-disintegration associated with loss of self-control The item clusters are anxious derealization (3) Visionary Restructuralization (VR) includes the item clusters elementary hallucinations (4) Auditory Alterations (AA) comprises auditory illusions and auditory (pseudo-) hallucinations (5) Reduction of Vigilance (RV) assesses changes in vigilance The results of the 5D-ASC data are given as percentage scores of maximum absolute scale values All data were analyzed using STATISTICA 7.1 for Windows (StatSoft Inc., 2005) Startle and PPI data were analyzed using three-way analyses of variance (ANOVA) with treatment (placebo and three psilocybin doses) and session (1 and 2) as well as either test block (startle: PA block 1–4) or PP trial type (PP30 Subsequently separate two-way ANOVAs with treatment and PP trial type as within-subject factors were calculated for each PPI session Two-way ANOVAs with treatment (placebo and psilocybin doses) and session (1–4) were used to test for significant effects of psilocybin on the FAIR attentional task indices while a three-way ANOVA with 5D-ASC dimensions (OB treatment (placebo and three psilocybin doses) and session (1–2) as repeated measure factors and subsequently separate two-way ANOVAs with 5D-ASC dimensions and treatment as within subject factors were used to examine the effect on the 5D-ASC scale Based on significant main effects or interactions Tukey's post hoc comparisons were performed Pearson's product moment correlations were conducted to explore the relationship between % PPI and psychological scores The criterion for significance was set at p<0.05 315 μ/kg) produced an altered state that was characterized by derealization and depersonalization phenomena The subjective effects of psilocybin began 20–40 min after drug intake The effects of psilocybin then gradually subsided and were completely absent 6 h after drug intake During the onset of the pharmacological action of psilocybin vegetative side effects including transient nervousness The psilocybin dose regimen applied in our study was physically and mentally well tolerated by all subjects with none of our subjects reporting persisting residual psychotropic effects in systematic follow-up investigations obtained 1 Dose–response effects of psilocybin (115, 215, 315 μg/kg) compared to placebo on the 5D-ASC obtained during the psychological peak phases of the drug. Mean scores±SE (n=16): OB=oceanic boundlessness, AED=anxious ego dissolution, VR=visionary restructuralization, AA=auditory alterations, RV=reduction of vigilance. Significant changes are indicted by **=ppost hoc<0.01; ***=ppost hoc<0.001. Dose–response effects of psilocybin (115 315 μg/kg) compared to placebo on the 5D-ASC obtained during the psychological post-peak phases of the drug Mean scores±SE (n=16): OB=oceanic boundlessness Significant changes are indicted by ***=ppost hoc<0.001 Post hoc test of the drug × ASC dimension interaction revealed that both the medium and high dose of psilocybin significantly increased the OB (d=1.24 and 1.26 and RV (d=1.54 and 1.66) scores (although to a much lesser extent compared to the peak phase) 315 μg/kg) compared to placebo on the FAIR attentional performance score P in healthy human volunteers obtained at 0 Significant differences are indicated by *=ppost hoc<0.05; ***=ppost hoc<0.001 As shown in Table 1 none of the psilocybin doses used significantly affected startle reactivity during the psychological peak or post-peak phases compared to placebo There was a significant session × block interaction (F(3,45)=2.88 indicating that startle reactivity pooled over doses may differ in a given block between sessions post hoc testing revealed no significant pairwise differences Subsequent collapsing of the data over dose and session revealed a significant main effect of block (F(3,45)=138.4 p<0.00001) with lower startle reactivity in the later than in earlier blocks the lack of a significant drug × block interaction indicates that psilocybin did not affect habituation An additional analysis of the %habituation data confirmed that habituation was not altered after psilocybin at any dose Dose–response effects of psilocybin (115, 215, 315 μg/kg) compared to placebo on percentage prepulse inhibition (%; mean±SE) at five PP conditions (ISI: 30, 60, 120, 240, and 2000 ms) in healthy human volunteers obtained during the psychological peak phases of the drug (n=16). ISI=interstimulus-interval. Significant differences are indicated by *=ppost hoc<0.05. Dose–response effects of psilocybin on percentage prepulse inhibition (%; mean±SE) at five PP conditions (ISI: 30 and 2000 ms) in healthy human volunteers during the psychological post-peak phases of the drug (n=16) Correlation between FAIR attentional performance (P scores) and percentage prepulse inhibition (%PPI) of pooled data across psilocybin doses obtained at the 30 ms lead interval during the psychological peak phases of the drug (n=48) there is as yet no published study that directly investigated the effect of psilocybin on PPI in animals the present findings further support the involvement of the serotonergic system in the modulation of sensorimotor gating and for the first time directly link PPI to controlled attentional performance these findings are consistent with the suggested contributions of 5-HT2A receptors to deficits in sensorimotor gating in schizophrenia patients leads to an additional stimulation of 5-HT1A receptors which in turn may have masked (at 60 ms) or counteracted (at 120–240 ms) potential 5-HT2A receptor-mediated PPI deficits at longer ISIs the fact that administration of even relative low doses of 5-HT1A agonist increased startle reactivity in the rat which was not the case in this study with psilocybin in humans One final caveat is that the highest dose of psilocybin (315 μg/kg) used in this study might not have been high enough to induce a full-blown psychotic state that might have been associated with more unidirectional effects of psilocybin on PPI Analysis of the 5D-ASC subscales revealed that psilocybin produced mostly depersonalization and derealization associated mania-like symptoms (OB scores) but only moderate anxious ego-disintegration Only at the highest dose of psilocybin some subjects experienced brief and transient episodes of paranoid thinking and misinterpretation of the experimental situation Given that the present dose regimen was well tolerated by our subjects in this as well as in previous studies with psilocybin in healthy volunteers the exploration of somewhat higher doses of psilocybin on PPI seems to be justified in a later stage of the investigation To our knowledge this is the first study simultaneously modeling deficits in PPI and sustained attention (and their association) as well as psychopathological symptoms via challenge of a hallucinogenic drug in healthy human volunteers The present study revealed complexities regarding the role of the serotonergic system in the modulation of PPI in humans It appears that overactivity at 5-HT2A receptors may be a common denominator of psilocybin- and DOI-induced PPI deficits seen at short ISIs in human and animal models of schizophrenia we suggest that the agonistic properties of psilocybin at 5-HT1A and/or 5-HT2A receptors are responsible for the apparent disparity between the PPI-enhancing effects of psilocybin in humans and the PPI-disruptive effects of DOI in animals at long ISIs The ISI-dependent effects of psilocybin on PPI stress the importance that startle sequences with graded ISIs (ranging from pre-attentive to perceivable ISIs) are used when pharmacological manipulations on PPI between rodents and humans are compared further studies of the concomitant effects of psilocybin on PPI and attention may help to elucidate the roles and interdependencies of serotonin receptors and their hypothesized interactions with other neurotransmitter systems in schizophrenia Lysergic acid diethylamide and serotonin: direct action on serotonin-containing neurons in rat brain Serotonin model of schizophrenia: emerging role of glutamate mechanisms 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex Human studies of prepulse inhibition of startle: normal subjects Gating and habituation of the startle reflex in schizophrenic patients Prestimulus effects on human startle reflex in normals and schizophrenics Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder Non-monotonic dependency of PPI on temporal parameters: differential alteration by ketamine and MK-801 as opposed to apomorphine and DOI Psilocybin: biphasic dose-response effects on the acoustic startle reflex in the rat SCL-90 (Symptom-Check-List): Self-report symptom inventory ECDEU Assessement Manual for Psychopharmacology Psychological aspects of altered states of consciousness of the LSD type: measurements of their basic dimensions and prediction of individual differences Current Status and Perspectives of Hallucinogens The standardized psychometric assessment of altered states of consciousness (ASCs) in humans International study on altered states of consciousness (ISASC) Serotonin releasers increase prepulse inhibition in serotonin 1B knockout mice Das Freiburger Persönlichkeitsinventar FPI Behavioral studies of hallucinogenic drugs in animals: implications for schizophrenia research Startle habituation and sensorimotor gating in schizophrenia and related animal models Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review Mouse genetic models for prepulse inhibition: an early review Startle response models of sensorimotor gating and habituation deficits in schizophrenia Hallucinogenic drug induced states resemble acute endogenous psychoses: results of an empirical study Effects of the hallucinogen psilocybin on habituation and prepulse inhibition of the startle reflex in humans The more or less startling effects of weak prestimuli Lysergic acid diethylamide and serotonin: a comparison of effects on serotonergic neurons and neurons receiving a serotonergic input Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind a measure of sensorimotor gating: effects of antipsychotics and other agents in rats Preliminary evidence of an association between sensorimotor gating and distractibility in psychosis Effects of typical and atypical antipsychotics on prepulse inhibition in schizophrenia: a critical evaluation of current evidence and directions for future research Prepulse inhibition of the startle response in men with schizophrenia: effects of age of onset of illness Deficits in prepulse inhibition and habituation in never-medicated Prepulse inhibition and habituation in first-episode schizophrenia LSD and the phenethylamine hallucinogen DOI are potent partial agonists at 5-HT2A receptors on interneurons in rat piriform cortex Control of serotonergic function in medial prefrontal cortex by serotonin-2A receptors through a glutamate-dependent mechanism Disorders of attention and perception in early schizophrenia Differential interactions of indolealkylamines with 5-hydroxytrypamine receptor subtypes Prepulse inhibition of the acoustically evoked startle reflex in patients with an acute schizophrenic psychosis—a longitudinal study Eur Arch Psychiatry Clin Neuosci 254: 415–421 Effects of antipsychotic drugs on serotonin receptors Three paper-and-pencil tests for speed of information processing: Psychometric properties and correlations with intelligence Information processing and attentional functioning in the developmental course of schizophrenic disorders Information-processing abnormalities as neuropsychological vulnerability indicators for schizophrenia 5-HT modulation of auditory and visual sensorimotor gating: II Effects of the 5-HT2A antagonist MDL 100 907 on disruption of sound and light prepulse inhibition produced by 5-HT agonists in Wistar rats Impaired prepulse inhibition of acoustic startle in schizophrenia Information-processing deficits and thought disorder in schizophrenia Sensomotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients Sensorimotor gating deficits in bipolar disorder patients with acute psychotic mania Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine Effects of ayahuasca on sensory and sensorimotor gating in humans as measured by P50 suppression and prepulse inhibition of the startle reflex Serotonin receptors represent highly favorable molecular targets for cognitive enhancement in schizophrenia and other disorders Automatic and controlled attentional processes in startle eyeblink modification: effects of habituation of the prepulse Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats DOI disruption of prepulse inhibition of startle in the rat is mediated by 5-HT2A and not by 5-HT2C receptors DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum Manual for the State-Trait-Anxiety-Inventory StatSoft Inc. (2005). STATISTICA (data analysis software system), version 7.1 www.statsoft.com Animal models of deficient sensorimotor gating: what we know Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges Changes in sensorimotor inhibition across the menstrual cycle: implications for neuropsychiatric disorders Advances and pathophysiological models of hallucinogen drug actions in humans: a preamble to schizophrenia research Brain mechanisms of hallucinogens and entactogens Psychological and cardiovascular effects and short-term sequelae of MDMA (‘Ecstasy’) on MDMA-naive healthy volunteers A systems model of altered consciousness: Integrating natural and drug-induced psychoses Positron emission tomography and fluorodeoxyglucose studies of metabolic hyperfrontality and psychopathology in the psilocybin model of psychosis Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans 5-HT modulation of dopamine release in basal ganglia in psilocybin-induced psychosis in man: A PET study with [11C]raclopride Download references We thank Dr Felix Hasler for technical support This investigation was financially supported by the Heffter Research Institute the Swiss Federal Office for Public health (BAG Grant No and by a NARSAD Young Investigator Award given to FH Dr Boris B Quednow was supported by the Deutsche Forschungsgemeinschaft (DFG Dr Mark A Geyer was supported by the US Veterans Affairs VISN 22 Mental Illness Research and Clinical Center and holds an equity interest in San Diego Instruments Neuropsychopharmacology and Brain Imaging & Heffter Research Center Download citation DOI: https://doi.org/10.1038/sj.npp.1301324 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Be one of the first to try our new activity feed Everyone in the industry seems to think I am in France for the Tour just as I did last year at TeamTBB camp in Leysin It’s great seeing old friends (coach Brett Sutton and athletes Rebekah Keat I brought my road bike and am excited to head out today after a day of jet lag sorting I have some new stuff to test in a beautifully appropriate locale And among the things we’ll see during the month-long saga available in the standard Path lens or the new XL with a longer 7mm nose bridge (which is functionally great for when down in the aerobars so you’re looking through the lenses and not over the frame) and available soon in that limited run at Oakley.com While you’ve now seen the new reverse jerseys (white instead of black) my interest lay in their tunnel-tested gear Like the Aero Race Team Jersey; the wind tunnel tested skin suit shoe covers and aero gloves will give the riders a technical edge to cut through the wind as well Here’s a shot of defending Tour champ Carlos Sastre checking out some of the fabric that Castelli’s Steve Smith is showing him and more of an aside: keep an eye out for a totally new TT helmet from Catlike with the Cervelo TestTeam; they had something at the wind tunnel that they were vehemently preventing me from taking photos of The body of the skin suit is made using Castelli’s Body Paint technology: a single piece of fabric to eliminate seams and cover your body as if it was painted on It’s cut short in the front so that when the rider is bent over in the riding position A flat elastic leg opening means for smooth air flow It’s finished with an aerodynamic flap to cover the riders race number Castelli’s Aero Race Shoecovers also have a “golf ball dimple” fabric We’ve asked if Normann Stadler will be wearing this at the Roth Challenge next weekend in Germany Just six of these cranks have been made (good luck getting one) hand-painted by a design studio that does up custom MotoGP helmets The planning for the renovation of the Gödöllő and Csömör suburban railway lines and their connection with metro line 2 will resume The work started earlier by the Budapest City Council and then stopped in early 2020 now continues by a consortium of the Budapest Development Centre (BFK) and MÁV-HÉV Zrt The government has already decided on the continuation of the work now the support contract has been signed - Budapest Development Centre (BFK) announces.  The entire suburban railway line in Gödöllő and Csömör will be renovated new accessible stops will be established (Source: Budapest Development Centre) The largest part of the investment is the complete renovation of the suburban railway line in Gödöllő and Csömör during which the track will be modernised and car passages crossing the suburban railway line will be eliminated Taking into account the changes in the settlement structure the location of the stops will also change: they will be placed where a significant number of people live or where it will be possible to transfer to the railway and more P + Rs and so-called B + R (bike and ride) parks will be built a transfer-free connection to Metro 2 would also be established That is planned to be solved by the metro driving up an ascent in front of today's Örs Vezér Square terminus which leads over the Kerepesi and Nagy Lajos Király Road and would reach the new Örs Vezér Square stop above the current suburban railway terminal The suburban railway line would be connected to the metro above the surface (Source: Budapest Development Centre) every second of the trains of Metro 2 would go to Rákosfalva every second of those would go further to Cinkota and every second of those would go to Gödöllő and Csömör The transfer-free connection can take place in 6-7 years The development can be realised in 6-7 years (Source: Budapest Development Centre) certain bus terminals will be moved from Örs Vezér Square which will allow buses to take up less space in the square and the area of the Zugló terminus will be landscaped That will also be planned by Budapest Development Centre (BFK) Cover photo: The suburban railway lines would be connected to the metro at the Örs Vezér Square - design render (Source: Budapest Development Centre)  © 2025 Látóhatár Kiadó Lap-és Könyvkiadó Kft What will be remembered as one of the closest Ironman finishes ever Jozsef Major grabbed his very first title with an amazing run at the 2008 Ironman Arizona Erika Csomor who hails from the same town in Hungary took the women’s crown with an equally impressive running performance A fairly large pro field entered the waters of Town Lake in Tempe AZ for the 2008 Ironman Arizona spring edition Halfway through the swim James Bonney surged away from Rene Goehler and came back into T1 with a 20 second cushion Wolfgang Guembel and Jonathon Caron was almost 2 minutes further back As the men started their multiple laps around Tempe Goehler slowly started to gain distance on Bonney and Tollakson and Rutger Beke methodically moved towards the front of the race Tollakson was barely a minute behind Goehler and about 20 seconds ahead of Bonney Beke was sitting in fourth position a bit more than 4 minutes behind A surge by Bonney around mile 55 though moved the lanky Texan back in front and he would keep that lead until mile 84 Tollakson was the new race leader and Jordan Rapp now was sitting in third position having clawed his way back into contention after a relatively slow swim Beke though seemed to slow down and many wondered what that meant (He would eventually drop out) A final surge by Bonney moved him back into the lead and first into T2 Bonney now had a 30 second lead on Tollakson a 2:30 lead on Rapp and over 8 minutes on the next pursuers but the big story of the day appeared to be Jozsef Major from Hungary who had previously shown some pretty impressive running ability He had started the run 16 minutes behind and by mile 8.5 he was just over 10 minutes behind At the halfway point of the run Bonney was within 4 seconds of Tollakson followed by Rapp at 3:12 and Major at 7:39 and all signs pointed to an extremely close finish Major though was just too strong and he streaked past Rapp Bonney and Tollakson for his first Ironman title Tollakson crossed the line 17 seconds later Rapp took third 46 seconds later and Bonney was fourth at 1:14 In the women’s race it was Tereza Macel who exited the waters first with Hillary Biscay and Michellie Jones just a few seconds behind Heather Gollnick came out of the water another 30 seconds later Jones quickly moved to the front on the bike and Macel started to drift back with various other early swim leaders Meanwhile though Erika Csomor was posting some very fast bike times after a not so fast swim By mile 76 Csomor had snatched the lead from Jones and looked very solid on the bike Csomor arrived first back in T2 with Jones 30 seconds back and Tara Norton just under a minute behind A very swift transition allowed Jones to be first out on the run but Csomor soon took the lead back and by mile 8.5 was 3.5 minutes clear of Jones Norton followed at 5:47 and Heather Gollnick at 10 minutes The lead of Csomor steadily grew and by the time she crossed the finish line she was almost 10 minutes up on second place finisher Jones and 13 minutes on third place finisher Gollnick © Slowtwitch - Built with Federated Computer we and our partners use technologies like cookies to store and/or access device information Consenting to these technologies will allow us and our partners to process personal data such as browsing behavior or unique IDs on this site and show (non-) personalized ads may adversely affect certain features and functions Click below to consent to the above or make granular choices. Your choices will be applied to this site only. You can change your settings at any time or by clicking on the manage consent button at the bottom of the screen Sarah Zarka laughs as she helps a customer check out at Wild Birds Unlimited .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Marina Csomor | MLive.com contributorEAST LANSING MI -- Always happy to help find a product or answer a question about birds Sarah Zarka is known by most customers as the friendly face of East Lansing’s Wild Birds Unlimited nature shop But Zarka is also the mind behind a Wild Birds Unlimited blog that is read by thousands of people across the world each week Zarka started the blog in 2008 and updates it daily “I wanted it to be sort of like a water-cooler thing,” Zarka said short blob (so) they could take it to the water cooler — ‘Did you know about this It’s time to put your hummingbird feeder up.’” Zarka and her brother opened Wild Birds Unlimited franchises in East Lansing and Okemos The idea for Zarka’s Wild Birds Unlimited blog was inspired by her customers Zarka would get so many bird questions from patrons — many of them repeat questions — that she decided to create an online resource where they could access answers Although she has never formally studied birds watching out her window and feeding birds for about 40 years there is no need to travel to scout out the most exotic species The birds found here in Michigan are fascinating enough to watch in her free time and discuss on the blog “She likes watching birds — has always been a backyard birdwatcher,” her brother Daniel Zarka said “And she has always liked to write and read so (blogging) kind of fits her personality.” a Wild Birds Unlimited customer who has contributed photographs to the blog said she looks forward to reading Zarka’s posts every morning “She tells you in advance per season what birds will be migrating into the area and who to watch for,” VanVoorhis said in an email “She tells you how to attract them to your feeder by food choices We live in the country and feed the birds and wildlife — we are fortunate to see a lot of different species you normally might not see in the city Since reading her blog and going into the store we get more birds and varieties than we ever have before.” Zarka doesn’t know of another website quite like hers — a blog with a focus on birds and other mid-Michigan wildlife updated each and every day Her intention in blogging has always been to get people excited “They’re a dinosaur that you can watch today,” Zarka said Follow Marina Csomor on Twitter: @MarinaCsomor. 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All rights reserved (About Us) The material on this site may not be reproduced except with the prior written permission of Advance Local Community Rules apply to all content you upload or otherwise submit to this site YouTube's privacy policy is available here and YouTube's terms of service is available here Ad Choices Metrics details Despite advances in the treatment of schizophrenia spectrum disorders with atypical antipsychotics (AAPs) there is still need for compounds with improved efficacy/side-effect ratios Evidence from challenge studies suggests that the assessment of gating functions in humans and rodents with naturally low-gating levels might be a useful model to screen for novel compounds with antipsychotic properties To further evaluate and extend this translational approach Compounds without antipsychotic properties served as negative control treatments healthy males received either single doses of aripiprazole and risperidone (n=28) Prepulse inhibiton (PPI) and P50 suppression were assessed Clinically associated symptoms were evaluated using the SCL-90-R and amisulpride increased P50 suppression in low P50 gaters and valproate did not influence P50 suppression in low gaters low P50 gaters scored significantly higher on the SCL-90-R than high P50 gaters Aripiprazole increased PPI in low PPI gaters whereas modafinil and lorazepam attenuated PPI in both groups P50 suppression in low gaters appears to be an antipsychotic-sensitive neurophysiologic marker This conclusion is supported by the association of low P50 suppression and higher clinically associated scores PPI might be sensitive for atypical mechanisms of antipsychotic medication The translational model investigating differential effects of AAPs on gating in healthy subjects with naturally low gating can be beneficial for phase II/III development plans by providing additional information for critical decision making We hypothesized that the administration of a single dose of the antipsychotics but not the negative control treatments will improve sensory and/or sensorimotor gating in healthy subjects exhibiting naturally low PPI and/or P50-suppression levels This study shall help to further elucidate whether antipsychotic effects on gating functions in low-gating normal humans might be a useful model to predict clinical efficacy of novel compounds for the treatment of schizophrenia spectrum disorders Three independent experiments adopting a double-blind All participants completed a placebo testing (maltose) whereas 28 subjects participated in the experimental procedure receiving aripiprazole (15 mg) and risperidone (2 mg) (cohort 1) 30 subjects underwent treatment with amisulpride (400 mg) and lorazepam (2 mg) (cohort 2) and 30 volunteers participated in the experiment with modafinil (200 mg) and valproate (500 mg) (cohort 3) Participants received the substances orally in a balanced and random sequence on three experimental days 10 to 20 days apart Subjects participating in one of the experimental series were not allowed in any of the two other series and valproate (Convulex) were obtained from the respective marketing authorization holders in Switzerland Selection criteria for negative control compounds were: (1) absence of an antipsychotic effect (2) no application in schizophrenia treatment and (4) no previous knowledge of the influence on gating to not introduce a bias participants received active drug or placebo after a short assessment of electrocardiogram Shortly before the onset of peak drug effect (aripiprazole: 115 min; risperidone: 70 min; amisulpride: 45 min; lorazepam: 100 min; modafinil: 120 min; and valproate 120 min) the subject was prepared for the electrophysiological recordings that took 45 min It should be noted that the study nurse was not blind to the medication as different time until onset of peak drug effect for the different medications had to be preserved and the data analyst were blind to the treatment condition The assessment of P50 suppression and PPI were conducted in two experiments that were separated by a 5-min break The P50 suppression test session was composed of 80 pairs of auditory clicks with a 500 ms interclick interval presented every 10 s (first click stimulus: S1; second click stimulus: S2) Stimuli consisted of 85 dBA white noise with a duration of 1 ms The P50 suppression session lasted for ∼15 min The PPI test session was composed of a mixture of 40 pulse-alone, prepulse-pulse trials, and trials in which no discrete stimulus other than the constant background noise was presented (‘NS trials’). For details see Supplementary Methods 2 the following ERP measures were examined: P50 amplitudes: P50 amplitude evoked by S1 and S2; and P50 suppression: percentage P50 suppression (%P50sup) was calculated by the formula: (1−(amplitudes2)/(amplitudes1)) × 100% For the PPI paradigm the following startle measures were analyzed Startle reactivity: the mean magnitude of the startle reaction elicited by pulse-alone stimuli Prepulse Inhibition: percentage PPI (%PPI) was calculated for each SOA according to the formula: (1−(amplitudeprepulse-pulse)/(amplitudepulse-alone (block2)) ) × 100% Habituation: percentage habituation was calculated as the reduction in startle magnitude between the second block and following block of PA trials to avoid sensitization effects: %Habituation=100 × (block 2−block 3)/block 2 To investigate the influence of treatments on electrophysiological indices in the low- and high-gating cohorts linear mixed-effects models were fitted for each of the six treatment conditions and for each dependent variable (%P50sup repeated measurements were accounted for by including random intercepts for the subjects In cases of heteroscedastic within-group errors the models were allowed to estimate separate variances for each group Akaike’s information criterion (AIC) values were used to decide on appropriate variance models of the within-group errors and correlation structures of random effects in model specifications Significant main effects and interactions were followed by Bonferroni-corrected pairwise comparisons If data were not normally distributed (PShapiro–Wilk W<0.05) nonparametric Wilcoxon matched-pairs tests were calculated in addition to contrast tests the significance level was set to p<0.05 (two tailed) the within-subject factor ‘drug’ (placebo vs active drug) and the between-subject factor ‘subgroup’ (low vs high gating) as well as their interaction were included in the models as fixed effects factors The models predicting P50 amplitudes additionally included the within-subject factors ‘stimulus’ (S1 and S2) and all possible interactions between the factors as fixed effects terms To test whether the divergence in %P50sup between the low and the high subgroups was based on differences in amplitudes elicited by S1 or S2 and to link changes in gating to modulation of a specific P50 amplitude (S1 or S2 elicited) Analysis of the %PPI values was performed with ‘SOA’ (30 and 120 ms) and ‘drug’ as within-subject and ‘subgroup’ as between-subject factor Startle amplitudes were subjected to the linear mixed model with ‘block’ (1 to 3) and ‘drug’ as within-subject factors and ‘subgroup’ as between-subject factor SCL-90-R data were analyzed by multivariate analyses of variance (MANOVA) with ‘subgroup’ as between-subject factor and SCL-90-R scales as within-subject factor Pearson’s product-moment correlations were calculated to relate placebo gating measures to the SCL-90-R global severity index (GSI) Demographic characteristics are summarized in Table 1 for low and high P50 and PPI gating subgroups in the three study cohorts The low- and high-gating subgroups did not differ in age with the exception of the low PPI gating group having a higher mean verbal IQ than high PPI gating group in study cohort 2 The influence of the AAPs aripiprazole (a) and amisulpride (c) and negative control treatments lorazepam (d) All AAPs significantly increased P50 suppression in low-gating healthy volunteers Lorazepam and modafinil reduced percent P50 suppression independently of low- and high-gating subgroups Differences in placebo gating within one cohort originate from the exclusion of invalid data sets in a nonpairwise manner *Significant difference between active drug and placebo Data were not normally distributed in the following subgroups and treatment conditions: modafinil Wilcoxon matched-pairs tests revealed a significant reduction in P50 suppression in the modafinil condition compared with placebo in the high-gating subgroup (modafinil vs placebo: Z=2.23 The analysis for valproate did not reveal significant results Results for the analysis of P50 amplitudes are described in detail in the Supplementary Results 1 and Table 2 increased %P50sup in the low-gating subgroup by an attenuation of S2-elicited P50 amplitude rather than by changes in S1-elicited P50 amplitude the negative control treatments reduced P50 suppression by an enhancement of S2-elicited P50 amplitude (modafinil) or a reduction of S1-elicited amplitude (lorazepam) and valproate (f) on sensorimotor gating expressed as percent PPI Aripiprazole increased PPI in the low-gating subgroup and decreased PPI in the high-gating subgroup Risperidone and amisulpride did not significantly influence sensorimotor gating Whereas valproate did not significantly modulate PPI lorazepam and modafinil attenuated sensorimotor gating independently of high- and low-gating group The analysis of startle habituation did not reveal significant main effects for the factors ‘drug’ and ‘subgroup’ or significant drug × subgroup interactions in any treatment group (Table 2; all p>0.05) the antipsychotic aripiprazole increased %PPI in subjects with low levels of sensorimotor gating and reduced %PPI in the high-gating subgroup lorazepam and modafinil reduced %PPI independently of subgroups Data were not normally distributed in the following subgroups and treatment conditions: risperidone Wilcoxon matched-pairs tests did not reveal any significant differences between active drug and placebo (all p>0.05) Results for the analysis of startle amplitudes are described in detail in the Supplementary Results 2 and Table 2 risperidone and lorazepam reduced startle reactivity whereas valproate increased startle reactivity independently of the subgroup Aripiprazole increased startle reactivity in the low-gating subgroup and decreased startle reactivity in the high-gating subgroup SCL-90 symptom scales (a) and global severity index (b) in the low (n=44) and the high (n=44) P50 subgroups *Significant difference between low- and high-gating subgroups For low (n=44) and high (n=44) PPI gating subgroups no differences were found in any of the SCL-90-R subscales or the GSI (all p>0.35) SCL-90-R GSI was not significantly correlated with placebo %meanPPI (r=0.12 The present study demonstrates first that a single dose of the antipsychotic aripiprazole and amisulpride increased P50 gating in low-gating healthy volunteers whereas the negative control treatments with lorazepam and valproate did not increase low levels of P50 suppression low P50 gaters scored significantly higher than high P50 gaters on the SCL-90-R global and all subscale scores measuring psychological traits and symptoms of psychopathology the atypical antipsychotic aripiprazole significantly increased sensorimotor gating in low PPI gaters The three psychoactive control substances without antipsychotic properties used here did not increase P50 gating in either the high- or low-gating subgroup although valproate had no influence on P50 suppression both lorazepam and modafinil reduced P50 suppression independently of the subgroup the present results strongly suggest that compounds with antipsychotic properties can be distinguished from nonantipsychotics by their effect on P50 gating in naturally low-gating healthy subjects although low P50 gating seems to represent a model sensitive for compounds with antipsychotic properties in general low PPI gating might rather capture atypical mechanisms of antipsychotic medication Future studies are necessary to obtain a clearcut picture as atypical antipsychotics involve complex receptor profiles that might differentially influence PPI capacity No significant effects were obtained for %habituation indicating that acute treatment did not influence startle habituation more research is necessary to be able to clearly differentiate the effects of antipsychotic and nonantipsychotic medication on PPI in low- and high-gating human subjects the present results might indicate that low P50 gating and low PPI gating in healthy subjects might be linked to different psychological processes and traits with low PPI gating being associated with cognitive deficits and low P50 gating with general psychopathology AAPs seem to increase low P50 suppression in healthy human subjects in line with a number of studies on treatment with AAPs in schizophrenia patients Effects of AAPs on low P50 gaters can be differentiated from the effect on high gaters and from the effect of negative control treatments in this study Although low P50 gating seems to be increased by antipsychotic medication in general low PPI gating might rather capture complex atypical multireceptor mechanisms of antipsychotic compounds The results regarding psychopathologically associated indices as indexed by the SCL-90-R are of great importance in the context of translational models as they bridge basic laboratory measures and clinically relevant indices the low-gating subgroup may be considered as a ‘surrogate patient group’ whose response can be differentiated from the high-gating group The results might be beneficial for planning phase II/III development plans by providing additional information for critical decision-making processes (eg as healthy subjects are widely available and compliant confounding effects of previous medication exposure and the generally nonrandom allocation of patients to treatment regimens are eliminated low P50 gating and low PPI gating models might reflect differential psychological processes and traits MAG has received consulting compensation from Abbott and holds an equity interest in San Diego Instruments MAG also has research grant support from Intracellular Therapeutics Veteran’s Administration VISN 22 Mental Illness Research The authors declare no conflict of interest Effects of bromocriptine and haloperidol on prepulse inhibition: comparison of the acoustic startle eyeblink response and the N1/P2 auditory-evoked response in man Understanding the pharmacokinetics of anxiolytic drugs American Psychiatric Association (1994) Diagnostic and Statistical Manual of Mental Disorders: DSM-IV 4th edn American Psychiatric Association (APA): Washington A systematic review of modafinil: Potential clinical uses and mechanisms of action Critical analysis and comparison of the side-effect and safety profiles of the new antipsychotics risperidone and chlorpromazine on auditory and visual latent inhibition executive function and eye movements in healthy volunteers Developing drugs for cognitive impairment in schizophrenia Effects of clozapine on positive and negative symptoms in outpatients with schizophrenia Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels Impaired prepulse inhibition and prepulse-elicited reactivity but intact reflex circuit excitability in unmedicated schizophrenia patients: a comparison with healthy subjects and medicated schizophrenia patients On the influence of baseline startle reactivity on the indexation of prepulse inhibition Auditory information processing in rat genotypes with different dopaminergic properties antipsychotic drugs potentiate a low level of prepulse inhibition shown by rats of the Wistar strain P50 gating at acute and post-acute phases of first-episode schizophrenia Prog Neuropsychopharmacol Biol Psychiatry 32: 1952–1956 Mood stabilizers increase prepulse inhibition in DBA/2NCrl mice Variables affecting prepulse inhibition of the startle reflex and the response to antipsychotics in DBA/2NCrl mice Franke G (1995) SCL-90-R: Die Symptom-Check-Liste von Derogatis—Deutsche Version The effects of sertindole on sensory gating Neuroleptic effects on P50 sensory gating in patients with first-episode never-medicated schizophrenia Translational research in central nervous system drug discovery Clozapine for the treatment-resistant schizophrenic A double-blind comparison with chlorpromazine Modafinil disrupts prepulse inhibition in mice: strain differences and involvement of dopaminergic and serotonergic activation How effective are second-generation antipsychotic drugs A meta-analysis of placebo-controlled trials Measuring P50 suppression and prepulse inhibition in a single recording session Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy The moderating role of the dopamine transporter 1 gene on P50 sensory gating and its modulation by nicotine Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs Assessment of subjective cognitive and emotional effects of antipsychotic drugs Auditory P50 in schizophrenics on clozapine: improved gating parallels clinical improvement and changes in plasma 3-methoxy-4-hydroxyphenylglycol Sensory gating in schizophrenics and normal controls: effects of changing stimulation interval Amisulpride the ‘atypical’ atypical antipsychotic–comparison to haloperidol P50 suppression and its neural generators in antipsychotic-naive first-episode schizophrenia before and after 6 months of quetiapine treatment Drug-induced potentiation of prepulse inhibition of acoustic startle reflex in mice: a model for detecting antipsychotic activity Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase but not on neuregulin-1 Arg38Gln genotype: a replication study Subjective distress related to side effects and subjective well-being in first admitted adolescents with early-onset psychosis treated with atypical antipsychotics J Child Adolesc Psychopharmacol 15: 249–258 Olanzapine improves deficient sensory inhibition in DBA/2 mice Clozapine improves deficient inhibitory auditory processing in DBA/2 mice Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications Antipsychotic effects on prepulse inhibition in normal ‘low gating’ humans and rats Clozapine enhances prepulse inhibition in healthy humans with low but not with high prepulse inhibition levels Impaired prepulse inhibition of acoustic startle in Chinese patients with first-episode Download references USA (IIT Grant to FXV) and Swiss Neuromatrix Foundation Switzerland (Achievement Grant to FXV and KHP) Philipp A Csomor and Katrin H Preller: The first two authors contributed equally to this work Neuropsychopharmacology and Brain Imaging and Heffter Research Center Supplementary Information accompanies the paper on the Neuropsychopharmacology website Download citation Pictured here is Maru's specialty Nirvana roll which is made of tempura fried smoked salmon .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Marina Csomor | MLive.com contributorMERIDIAN TOWNSHIP MI -- Robert Song wants his restaurant to be known as a place where diners feel at ease He doesn’t want customers to worry if they don’t know what an ingredient is or how exactly to pronounce a dish on Maru’s menu of Japanese cuisine “Who cares what it’s supposed to sound like including hibachi grilled meat and vegetables Although Maru’s sushi is made using traditional methods many of the items on the restaurant’s menu are original creations It serves signature rolls such as the Papa Crema — a crab and tempura fried roll topped with sweet garlic potato salad — and specialty rolls such as the Cosmo — a shrimp tempura roll topped with tuna and drizzled with honey wasabi aioli and spicy mayo Song said his chefs wanted to make sure their dishes stood out from common cuisine served at other Japanese restaurants “We didn’t want to just change out two ingredients and call it something else,” Song said Laingsburg resident Pieter Lugt and his wife eating out at the restaurant about once a week Lugt said he appreciates the fresh fish that always is available at Maru Song strives to use Michigan products in his restaurant whenever possible if you do find something that a farmer grew the quality is unmatched (to) something harvested three he decided to expand and opened a second Maru location in Grand Rapids in September Song’s third Maru restaurant will open in East Lansing at 1500 W but he never imagined he’d make cooking his career Song thought he would go to medical school like many of his friends But while a student at Michigan State University he changed his major to dietetics and found himself working in various restaurants while earning the food-related degree Soon he realized he could see himself making a living in the restaurant industry Maru’s interior design is simple and modern There are high ceilings and a bar at which customers can sit and watch chefs prepare their sushi Lugt said it’s difficult to find sushi anywhere else in the Lansing area that compares in quality to the rolls served at Maru He and his wife have many favorite menu items from the Dragon roll and Maru Signature Salad to the saketini and green tea creme brulee “These guys are just masters at what they do,” Lugt said Pictured here is Thai Princess's Drunken Noodle or Pad Khee Mhow a dish of sauteed flat noodles with chili paste MI -- There is a laundry list of restaurants in the Lansing area that serve Thai dishes none offer food that compares to the cuisine she ate while living in Southeast Asia in 1962 — except for Thai Princess “It’s more like the real Thai food than any other place I’ve found,” the Bath resident said 1754 Central Park Drive in Meridian Township prides itself on preparing authentic Thai cuisine Customer favorites include rice noodle dish Pad Thai and the sweet and sour Mango Delight made with chicken or shrimp most items served are made fresh in the Thai Princess kitchen who helps run the restaurant with his wife “We only use fresh vegetables,” Clarkson said “We don’t use any canned or pre-processed vegetable The restaurant’s decor feels natural and elegant Although Thai Princess expanded in the spring the restaurant hasn’t lost its personal touch Wrigley said one of her favorite things about Thai Princess is the restaurant’s friendly staff Thai Princess will celebrate its third year in business Ratanaruch started the restaurant after moving to the Lansing area from New York City where she had also owned and operated a few eateries Ratanaruch went to culinary school in Thailand before moving to America she is happy to bring her authentic Thai cooking to Thai Princess’s customers “She has other people that work in the kitchen that do cooking as well but she supervises all of the dishes to make sure things are done the way she wants it to be done and tastes the way she wants it to taste,” Clarkson said Clarkson said customers will not find standardized decor or standardized food at Thai Princess they are drawn to the restaurant’s natural atmosphere and its fresh food that makes it feel like home traditional style and less big-city style,” Clarkson said country cooking versus fast food cooking.” Pictured here is DeLuca's spinach pizza .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Marina Csomor | MLive.com contributorLANSING MI -- A city staple for more than 50 years DeLuca’s and its Italian food has long been a familiar comfort for Lansing-area residents “People just feel like they’re at home when they come here,” said John DeLuca who owns the Italian restaurant along with his two brothers “I have people tell me that they’ll have a bad day at work or something and they'll come here with their wife is known to have some of the best pizza in town Customers enjoy everything from the classic house special Romano cheese and olive oil on a thin crust A neighborhood hangout for local factory workers the Willow Bar was most popular for the pizza it served but everybody always really liked the pizza,” DeLuca said we just started slowly emphasizing pizzas more and it just kind of morphed into what it is today.” Lansing resident Tom Lindemann has been a DeLuca’s customer for more than 20 years He said it’s the restaurant’s good food and familial atmosphere that keeps him coming back “The fact that it has been family owned since its inception just gives it more of that homemade DeLuca and his brothers inherited their knack for Italian cooking from both their father we kind of inherited some of her skills,” DeLuca said DeLuca said the restaurant has tailored authentic Italian recipes to suit its American customers’ tastes DeLuca said he is most concerned with consistency in the taste and quality of the food he serves “We work very hard at keeping it consistent,” DeLuca said “We make our own dough and sauce every single morning and we buy really high-quality ingredients We really try to use the best stuff we can.” Bath Township resident Chuck Valentini said he often makes the trip to DeLuca’s because he looks forward to the restaurant’s homemade pizza and Italian dishes “It’s out of the way a little bit for me to get here — Eastwood Towne Center’s more convenient,” Valentini said Aloo Beans and Naan from the weekday lunch buffet at Sindhu Indian Cuisine in East Lansing Rand Spiro has been a faithful customer of East Lansing’s Sindhu Indian Cuisine Spiro simply has to travel a few short minutes from work to Sindhu’s Hagadorn Road location to guarantee a well-prepared meal made with fresh ingredients and you know the food’s going to be good,” the Bath resident said “You know you’re not going to have a long wait to eat because it’s a buffet.” is open seven days a week — lunch is served from 11:30 to 2:30 p.m and dinner is available from 5:30 to 9:30 p.m The restaurant offers a lunch buffet and dinner menu containing a variety of both meat and vegetarian Indian dishes Sindhu owner Erupaka Reddy said the restaurant employs chefs who specialize in cooking Indian curries Sindhu Indian Cuisine has enjoyed almost 17 years of steady business at its location on Hagadorn Road But Reddy said he cannot take complete credit for Sindhu’s success She’s the one who wanted to start a restaurant in the beginning.” in 1980 to earn his master’s degree in geology Reddy said there was no Indian cuisine available in the Lansing area He didn’t devote his full time to the restaurant until 2001 With a college campus so close to his establishment Reddy said he enjoys being a business owner in East Lansing “Mostly our regular customers are Michigan State — MSU students and faculty,” Reddy said Spiro said Sindhu serves the best Indian food in the Lansing area and it has just kept getting better and better so they definitely seem to be attending to what they’re doing and not coasting or resting on their laurels,” Spiro said The company has purchased a production line for photovoltaic solar modules from the Spanish manufacturer Mondragon Assembly Romania Vladimir Spasić 0 Karpat Solar has signed an agreement with Spain’s automation and assembly solutions provider Mondragon Assembly to supply a production line for photovoltaic solar modules with a capacity of 100 MW per year A solar panel contains one or more solar modules which consist of solar cells connected in series of parallel circuits has the ambition to become the first module manufacturer in Romania The 100 MW in modules is the first phase of a large-scale project that will initially secure the production for the local market but with an ambition to expand in the European Union says he expects the capacities to be in full production before summer It will allow the company to tackle the Romanian market in autumn 2021 the use of renewable energy is growing exponentially in Romania and the firm intends to make a “small contribution,” according to Károly Karpat Solar will locally manufacture high-efficiency modules under the strictest quality parameters Romania has 1.4 GW in installed solar capacity. In early March, S.C. West Power Investment Srl announced a plan to install a 700 MW solar power plant Several module manufacturing projects will come online in Europe in 2021 international sales manager at Mondragon Assembly said that in 2021 several module manufacturing projects would come online in Europe They will differ both in size and in manufactured products and technological diversification is expected “In addition to the standard modules we will see companies launching modules for HJT BIPV and other niche products suited to European demand where Mondragon Assembly has the solution for all those new technologies,” Herrarte added Be the first one to comment on this article 02 May 2025 - The project is located in Constanța county recognized for its superior yields in green energy production Slovenia 02 May 2025 - The Sunčana (Sunny) Vipava project envisages installing solar power plants with a combined capacity of 20 MW Region/EU one of the largest wind turbine manufacturers in the world 30 April 2025 - OMV put into operation its 10 MW green hydrogen plant at the Schwechat refinery © CENTER FOR PROMOTION OF SUSTAINABLE DEVELOPMENT 2008-2020 website developed by ogitive sits with another monk at their residence at Dhammasala Forest Monastery .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Marina Csomor | MLive.com contributorPERRY MI -- Teachers like Ajahn Khemasanto are few and far between “American monks are as rare as hens’ teeth,” Ajahn Khemasanto said Ajahn — a title that means teacher in Thai — Khemasanto is the head Theravada Buddhist monk at Dhammasala Forest Monastery Sitting on 28 acres of land about a 30-minute drive from Lansing There are usually three monks who live on the property although one is currently away in Virginia Dhammasala has its roots in the area’s Thai community Its monks observe the Theravada school of Buddhism It is a place for the Thai community to come together and practice Buddhism as well as for others to take Buddhism and meditation classes and go on spiritual retreats Lao and Sri Lankan who come from the Lansing area Dhammasala is the only Theravada temple in the Lansing area although there are others in the Detroit area and in Holland a doctoral student at Michigan State University said she appreciates the part Dhammasala plays in both her religious and social lives as well as to learn from the resident monks I wanted to have something to calm me down,” Chamaphorn said The life of a monk at Dhammasala is quite different from a monk living in Thailand He and his fellow monks get up about 5 a.m. do their morning chanting and clean before visitors start arriving at 10:30 a.m so people bring food offerings to Dhammasala the monks usually work on upkeep of the property including cutting the grass and making repairs Chamaphorn respects Ajahn Khemasanto because he leads by example “He is not only the monk by wearing that robe,” she said Ajahn Khemasanto has been a Buddhist since he was about 13 years old he was first introduced to Buddhism while reading National Geographic there was no such thing as a computer — wasn’t internet — and there were almost no books on Buddhism and there was only one temple in America and that was in Washington D.C.,” Ajahn Khemasanto said There Ajahn Khemasanto worked for nonprofit organizations as well as lived as a monk for seven years he returned home to Michigan to see his ailing father said Dhammasala is an asset to the community because it provides information to the many people who don’t know Buddhism’s true teachings “They don’t really know what Buddhism is,” Chaiwang said “They sort of think it’s just like Zen Buddhism It helps because we have Ajahn here who speaks both Thai and English so he’s able to give talks and lessons and answer questions.” For those looking to learn more about Theravada Buddhism they feel lucky to have a teacher so close Ajahn Khemasanto wishes he had had such guidance when he was young and so you can memorize the whole menu and recite the ingredients and everything but have never tasted it I remember how awful it was when I was young and read what few little books I had and most of them very confusing Ajahn Khemasanto would like to go back to Thailand But he knows he can’t leave Dhammasala without an English-speaking teacher — the temple’s other monks are Thai “I don’t think about the future at all because Buddhists don’t really do that kind of thing,” Ajahn Khemasanto said Because my hopes for the future would mean I’d want it to go a certain way and then it wouldn’t go that way Wild Goose Inn owner Al Bay stands in front of the fireplace in the living room of his bed and breakfast MI -- Al Bay’s home has always been the hub.It started with his mother — growing up she always welcomed friends to their house as president of Michigan State University’s rowing team Bay’s residence was often the site of team social events Bay has old friends and new guests alike staying at his home every day This quaint property is hidden among downtown East Lansing’s commercial buildings and student-centered housing “That’s one difficult thing is to get people to understand that the inn is more than just a nice house,” Bay said that’s a bed and breakfast,’ but I don’t think that they think of a room with a jacuzzi in addition to the standard television and Internet resident Zuzanna Diaz had been hoping for the chance to stay at Wild Goose Inn for about five years and finally was a guest in March who had friends living on the property while he was a student at MSU had given her a tour of the inn on their first date “It was a lot more personal than a hotel,” Diaz said of her stay Bay is proud to be a member of the community and leave guests with a good impression of the city the Eli and Edythe Broad Art Museum and Wharton Center for Performing Arts so close Bay said there is no better place for a bed and breakfast “I like that we have things that a big city might have to still have residential neighborhoods so close So for all of those reasons I like being here considers Bay’s personality to be perfect for owning a bed and breakfast — he’s easygoing and a people person Bay naturally becomes friends with almost everyone he meets “He’s just a really good friend of mine,” Martin said “I’ve grown to like him as a friend more than a boss through the years Although he wasn’t able to establish Wild Goose Inn until he was in his 40s Bay had dreamed of starting such a business since he was about 20 years old Having stayed in bed and breakfasts during many East Coast rowing competitions and vacations over the years Bay had long appreciated the charm and comfort of such lodging Bay has lived on the Wild Goose Inn property for more than 30 years But it wasn’t always located on Albert Avenue Bay moved the house from a few miles down Grand River Avenue — it previously was located near Denny’s in East Lansing — with the intention of finally starting his bed and breakfast downtown Bay has a full-time job working for the Michigan Department of Community Health His business has always been his side project But his passion keeps him willing to work at the inn after hours particularly the guys — they’ll think that they’d rather be in a hotel and they realize that they’re actually very comfortable here and they don’t feel like it’s somebody else’s house I like for people to be able to take off their shoes and feel like they belong here.” Tickets & Hospitality Matches Shop LUTV Foundation More... Leeds United Women fell to a 2-0 defeat against Barnsley Women’s FC in their second game of the season Rick Passmoor’s injury-hit squad fell just short against a strong and organised Barnsley side who retain their place at the top of the table The Whites were missing six first team players due to injuries and illness plus Paige Williams who was serving the first of a three game ban following last week’s red card Leeds started well and had the first chance of the game when Laura Bartup headed over from an Olivia Smart corner on four minutes but less than a minute later it was the hosts who took the lead Emily Pierrepont latched on to a long ball over the Leeds defence and coolly lobbed over Leeds goalkeeper Carrie Simpson It was 2-0 to Barnsley on 11 minutes when a high cross from the left wasn’t dealt with by Leeds and Courteney Csomor arrived at the back post to head in The hosts threatened to make it 3-0 on 19 minutes with two chances from successive set pieces Simpson made an excellent stop to deny Jodie Michalska and Amy Beck flashed a header just wide Bartup had Leeds’ best chance of the half two minutes later she was played clean through by a brilliant diagonal ball from Cath Hamill She tried to lob Barnsley keeper Serena Clarke but put too much on it and it sailed over the bar Leeds continued to press but struggled to create chances the best they could muster before the break was when Abby Brown smashed a volley wide on 41 minutes Beck came close again for Barnsley on the stroke of half time she met a corner with a powerful header but couldn’t keep it down HALF TIME: Barnsley Women 2-0 Leeds United Women The second half started slowly with neither side really getting a hold of the game as both teams came out unchanged from the teams that had began the match Barnsley looked to continue threatening from set pieces with Shaw and Beck both failing to convert headed chances Leeds’ best chance to halve the arrears came on 75 minutes when Danielle Whitham's shot was blocked into the path of Bartup The striker remained calm in the box to dummy past a Barnsley defender but saw her shot brilliantly saved by Clarke who has having an impressive afternoon between the posts for the Reds The Whites began to build a bit of momentum after that Bartup saw a free-kick blocked and Leeds stayed on top for the remainder of the game but couldn’t break down a very strong Barnsley team Passmoor’s side have a chance to return to winning ways quickly as they face Stockport County on Wednesday evening in a 7:45pm kick off at Tadcaster Albion’s So-Trak Stadium Full time: Barnsley Women 2-0 Leeds United Women Map The renovation of the HÉV line to Gödöllő and Csömör, as well as the urban connection with metro line 2 at Örs vezér tere will cost a total of 200 billion forints, and should be completed by 2027. Here are some visuals to give you an idea of how the design will look. This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Play Duration: 5 minutes 7 seconds5m Brought to you by This year, the children at Parap Primary School in Darwin have prepared a special Christmas treat for Australian troops serving around the world. Care packages with socks, lollies, games, and hand written notes have been lovingly made by the children in the hope they’ll bring a bit of cheer to those who can’t be home for Christmas.   ABC's Alenka Csomor caught up with Kim Morgan, the assistant principal at Parap Primary, and also with some of the children to get a peak at the care packages. The kids at Parap Primary are very proud of the 180 packages they've made for Australian troops serving overseas this Christmas. (Photo by: Alenka Csomor ) More EpisodesDrivePublished: 3h agoTue 6 May 2025 at 6:30am Published: YesterdayMon 5 May 2025 at 6:30am Download the ABC listen app to text and call your favourite live radio A two-day international neo-Nazi music festival was held at the Petőfi Sándor Cultural Center in Csömör on 11 and 12 October after the venue was rented under the pretence of hosting a private birthday party the organisers attempted to keep the event’s location hidden but it was later identified through photos shared by one of the performers The director of the cultural centre, László Szeltner, told HVG that they had no prior knowledge of the true nature of the event The venue had been rented for a private birthday party and it wasn’t until later in the day that Szeltner became aware that “guests with unusual appearances” had arrived He immediately notified the local government and police the authorities allowed the event to continue as planned but it took place behind closed doors under heightened police and civil guard presence Szeltner emphasised that no incidents occurred during the gathering Szeltner assured that the centre would take stronger precautions to prevent similar events from happening in the future This incident bears resemblance to another far-right gathering in Hungary last year a supposed martial arts event in Csókakő was revealed to be a far-right meeting attracting hundreds of extremists from across Europe The local mayor had requested the organisers cancel the event due to its neo-Nazi nature but the organisers denied the accusations and proceeded with the event as planned Like flies to excrement the neo-Nazis unfortunately always seem to end up in Hungary @michaelsteiner – “good people on both sides”?? Let´s be VERY clear what neo-Nazi means. I will keep it simple TLDR – https://en.wikipedia.org/wiki/Neo-Nazism : “Neo-Nazism comprises the post-World War II militant and political movements that seek to revive and reinstate Nazi ideology Neo-Nazis employ their ideology to promote hatred and racial supremacy and in some cases to create a fascist state.” I will spare everyone the Holocaust denial / promotion Hungary was part of the Axis and complicit in the Holocaust – which puts an even higher moral burden on us to combat this sort of thing In their eyes every body who is not in complete lockstep with their own very warped understanding of democracy is an neo-nazi I would avoid as the plague anything events of which they approve I am pretty sure this is not the whole story Spending a weekend listening to skinhead bands sounds like masochism more than anything else and website in this browser for the next time I comment Y"},"category":false,"taxonomy":{"active":false,"name":"category"}},"markup":{"custom_html":true,"wpp-start":"","wpp-end":"<\/ul>","title-start":"","title-end":"<\/h2>","post-html":"{thumb} {title} {stats}<\/span>{excerpt}<\/p><\/li>"},"theme":{"name":""}} You have successfully joined our subscriber list SupportUs Newsletter © 2025 DailyNewsHungary | All rights reserved A Hungarian woman has managed to escape a situation that could have turned much grimmer, according to nottinghampost.com managed to escape from the brothel she found herself in The Hungarian woman was offered a cleaning job in Chilwell by a woman after whom police are now searching she soon realised that she was brought to a rented flat in the Selside Court under false pretences that is how she realised she was expected to do something other than cleaning When it was suggested that she should dip her toes into prostitution all her documents and one of her phones were taken away from her she was threatened by one of the people behind the human trafficking scheme and told she was going to stay no matter what so she was able to contact her mother in Hungary and ask for help she had to warn her mother to do things quietly as “if they found out about it they would hide her so the police would not find her.” The mother immediately turned to the police and helped them to free her daughter by providing them additional information The Chilwell brothel is only one of many alleged illegal brothels operating in the UK as hotbeds of human trafficking. The women found in the brothel were mostly from Hungary who arrived in Britain by plane or by ferry they were moved around from brothel to brothel a curious detail of this case is that this time the people luring the Hungarian woman to the brothel were also Hungarian: All of them are on trial now for bringing the women to the UK as well as trafficking them within the borders They deny these allegations as well as taking advantage of the girls and sexually exploiting them by making them work as prostitutes only Csaba Csomor junior has pleaded guilty to the allegations For more related news, check out this article about the Hungarian little boy who got stuck in America because of the strict immigration policies. More than 200 harassments may have already taken place on the HÉV lines in Gödöllő and Csömör A petition demanding security guards and cameras has already been signed by 3,749 passengers MÁV knows only about one single passenger harassment the number of passengers who have signed a petition demanding cameras and security personnel for suburban railway cars has jumped to 3,749 there may have been more than 200 harassments on the Gödöllő and Csömör suburban railway lines acts of violence and vandalism occur almost weekly on the Gödöllő line of HÉV there was an attempted rape; the woman resisted an investigation has been launched about the case Telex contacted the press department of MÁV-HÉV to get more information on exactly how many violent cases they know about and whether there is an emergency button or a camera in the trains what they are planning to do to increase passenger safety according to a new “practice” introduced this year the company did not answer Telex’s questions and the paper had to submit a public interest data request in which they revealed that to the company’s knowledge there has been only one violent case against passengers in the past year that there were 29 cases of vandalism and 13 cases of attacks against the ticket inspectors after the government declared an emergency situation due to the coronavirus pandemic there was a one-month period of increased inspection with police officers and civilian guards The answer also included that there is a single camera system operating in a three-car train on the Szentendre line The current suburban railway cars are not planned to be equipped with cameras and emergency buttons but they might be part of the standard equipment of the new cars intended to be purchased MÁV-HÉV recommends that anyone in trouble should activate the emergency brakes the emergency brakes are not a viable option there were emergency buttons on the car doors that signalled the driver those buttons were decommissioned about a year or two ago The reason was revealed in another reader’s letter: “I wrote last May because the driver did not see the door of the back car and closed the doors on an elderly man several times It was then that several people noticed that the emergency buttons were missing.” The official response to the inquiry was that the pushbuttons for alarm were decommissioned due to an official decision by the authorities Due to the cost implications of meeting the conditions set out in the decision There are no future plans to install new emergency buttons MÁV-HÉV plans to purchase 54 (42 in the first batch) suburban railway cars for the H5 and H7 suburban railway lines (but not for the problematic H8 Gödöllő line) The total cost of the cars is not yet known it can be estimated to be over HUF 200 billion (€548 million) The first round of the tender for the purchase was announced in September it was already known that two large companies air-conditioned vehicles equipped with Wi-Fi will come sometime in the first half of 2021 after the public procurement procedure as MÁV-HÉV plans to conclude the contract by then But the new cars will only be operational around 2023 Passengers will be able to travel all the way to the Déli railway station in Budapest on HÉV without having to transfer at the current terminus of the M2 metro line at Örs vezér Square This means that it will be less complicated to reach destinations like Gödöllő and Csömör transfer-free transport between downtown Budapest The current metro line will be connected to the HÉV line ensuring more convenient travelling conditions for those living in the outskirts This also means that visiting the Royal Palace of Gödöllő will be much simpler According to Világgazdaság the project concerning the public transportation of four districts of Budapest will be funded by the EU Design contracts may be concluded in the first half of next year and the design process may take two to three years the implementation of the project itself will begin the future developments will solve one of the biggest traffic problems in the district the trains will run underground and on overpasses the investments will also be significant in protecting the environment added that the goal is to improve public transportation in the XVIth district of Budapest It should be implemented in such a way that it creates the most ideal conditions for the people living in the district The investment will have a beneficial effect on the value of real estate and the development of public areas in the district as well improved system of public transportation prices and passes is available in Hungary County and Hungary passes (Vármegye- és Országbérlet) are available to purchase currently which means that you are not able to buy kilometre-based tickets anymore The simplification includes the reduction of the number of discounts available Passengers have two options: either buying a full-price ticket or one with a 90% discount Discounts also include free travel for families raising three or more kids and people under 14 and above 65 can travel freely too young people between 14 and 25 can buy tickets for a 50% discount Students travel with a 90% discount regardless of their age “the project concerning the public transportation of four districts of Budapest will be funded by the EU” almost all of it will be money Hungary had paid into the E.U and is now “graciously” getting it back