Stories of adventure and the coolest product releases delivered straight to your inbox “What’s the best backpack for elk hunting?” That’s one of the most frequently asked questions along with those about the best caliber—obviously the 7mm—or boots when it comes to Western hunting as the right pack can be the difference between a successful mission and a shit show.  I used a backpack from my days in the sniper teams The old adage of “two is one and one is none” might be good for combat but it weighs you down with a lot of unnecessary shit on a hunt That beatdown with 70 pounds of who knows what in my pack coupled with 20 years of technology improvements in packs results in a much better all-around hunting experience.  This simplified packing philosophy keeps my pack trim and free of crappy or complex equipment that can easily ruin a trip All that gear gets packed neatly into Eberlestock’s EMOD pack system One of the greatest appeals of the EMOD system is its versatility as it can be just as easily used for prolonged stays in the mountains as it can for day hunts The foundation is the Mainframe, it’s essentially bombproof, and it’s just as comfortable with 20 pounds of gear as it is with 100 pounds of elk meat strapped on. Now here’s the cool part: the company has a variety of different bags in the EMOD line that attach to the frame in seconds via a rugged zipper system. The Vapor 2500 usually graces the frame it’s a simple single-compartment design with 2800 cubic inches of capacity—which is plenty to accommodate a multi-day trip What I really like about this setup is the meat-packing capability Meat is loaded between the Vapor and the Mainframe—remove the bag then reattach the bag on top via the compression straps This keeps the weight close to my back and  blood off my gear Dry weight of this combo is about 5.5 pounds which is fine for me as I’ll sacrifice carrying a little more weight for a system I can count on I’ve been burned by a lightweight backpack that didn’t live up to its advertised ability The modularity of Eberlestock’s system makes it easy to plan for contingencies, which I always make sure to do. With the 2500 doing most everything I need, the Vapor 5000 lends itself perfectly to longer expedition-style hunts The loadout stays the same with some additional food and camp items.  The EMOD system is a do-all system with different bag options to be used in varied pursuits. I’ve used mine for years and have no intentions of retiring it anytime soon.  Cost: Mainframe $299; Vapor 2500 $199; Vapor 5000 $259; Batwings $60 (per bag)  Cons: Slightly heavier than a lot of other hunting packs Stories of adventure and the latest product releases delivered straight to your inbox Subscribe to the Field Ethos Print Journal An algorithm for real-time anomaly detection lead image Real-world statistical systems are often complex and efficiently detecting minor anomalies can be the key to avoiding catastrophe small timescale changes in the current and voltage output of an inverter can indicate a short circuit many methods for detecting anomalies are insufficient relying too heavily on simple models and prior knowledge adaptive algorithm for identifying such anomalies called the exception maximization outlier detection (EMOD) algorithm By treating all datasets as a blend of primarily normal data with a few abnormalities sprinkled in EMOD can identify hidden outliers without needing to know specific details about the data’s behavior EMOD updates this understanding in near-real time… It’s continuously refining its understanding of what’s ‘normal’ versus ‘abnormal,’” said author Mingyuan Zhang the team found EMOD can quickly and accurately deliver alerts when a complex circuit system’s output indicates a short it works continuously and does not erroneously report abnormalities after the circuit has returned to its working state The researchers also effectively applied their algorithm to study insured unemployment data in the United States at the height of the COVID-19 pandemic Any time-series dataset that needs anomaly detection can utilize EMOD “I’m most eager to see EMOD applied to monitoring complex real-world systems—especially those where anomalies can have critical consequences,” said Zhang pointing to examples such as detecting chemical anomalies in rivers for early signs of pollution or real-time analyses of medical device signals for quick diagnoses Source: “Machine learning for complex systems with abnormal pattern by exception maximization outlier detection,” by Zhikun Zhang, Yiting Duan, Xiangjun Wang, and Mingyuan Zhang, Chaos (2025). The article can be accessed at https://doi.org/10.1063/5.0250852 This paper is part of the Advances in Mathematics and Physics: from Complexity to Machine Learning Collection, learn more here 2024 /PRNewswire/ -- Utah-based Evolve has been named Medicaid Managed Care Company of the Year by Eldercare Review shows the impact of Evolve's unique service model Utah-based Evolve has been named Medicaid Managed Care Company of the Year by Eldercare Review "It's wonderful to be recognized by our fellow peers in healthcare," Cheever said of the award "This nomination came from subscribers of the publishing company It's a comment on the effectiveness not just of our business sustaining relationships with partners across the country." Evolve's business model started with helping people use government benefits and other social programs to get the home modifications—shower grab bars and the like—that allow them to continue living independently in the community "aging in place." Study after study has shown that living at home as they age is the strong preference of the vast majority of people but that isn't always possible without some changes to the home environment as well as feedback from clients and partners across the country has led Evolve to expand into different types of home enhancements from power backup systems that keep life supporting medical devices functioning to air purifiers and recommendations from an advisory board Evolve navigates the complex intersection of health care and home modification services to ensure that each resident's unique needs are met," reads the magazine's announcement "The company also simplifies the process of accessing medical benefits making it easier for residents to obtain essential services and home modifications that improve their living conditions By coordinating Medicaid coverage for health care services and home enhancements Evolve helps ensure that residents receive the support they need without financial burden." Evolve's unique service model has made the company an invaluable partner to managed-care companies navigating the intersection between client needs Evolve operates across state lines with deep knowledge of how to best navigate publicly funded programs as well as an extensive network of local contractors who can get jobs done quickly and in ways that best meet clients' needs The company currently operates in nine states The company handles more than 3,000 service requests each year and partners with nearly two dozen national and regional health plans and state programs For more information about Evolve, visit www.evolve-emod.com Click here to read the full article Spike Cheever, Evolve, 844-438-7577, [email protected] Do not sell or share my personal information: The company has secured contract extensions to supply its advanced two-speed transfer cases for upcoming vehicle models that align with new platform specifications BorgWarner has expanded its transfer case supply business with a significant North American Original Equipment Manufacturer (OEM) This extension will see BorgWarner providing two types of high-performance transfer cases: the Electro-Mechanical On-Demand (EMOD) and Electric Shift-on-the-Fly (ESOF) reinforcing a supply partnership with the OEM that spans more than four decades this marks its first application in a specific passenger truck category highlighting its flexibility and robust architecture The ESOF transfer case designed for heavy-duty part-time four-wheel drive trucks offers an efficient two-wheel drive mode alongside the capability to engage four-wheel drive while the vehicle is in motion achieving enhanced performance suited to demanding driving conditions Now in its third evolution on the OEM's passenger truck platforms the ESOF’s smooth-shifting technology continues to demonstrate its reliability and effectiveness for rugged applications Both transfer cases incorporate BorgWarner's HY-VO driveline chain optimised for high efficiency and improved durability and are manufactured with the company’s premium friction products The production will be based at BorgWarner's Seneca BorgWarner Supplies Advanced Electric Torque Vectoring, Disconnect Systems To Polestar Truck Rentals Flat In April Despite Toll Hikes; Freight Undercurrent Turns Mildly Positive Yamaha Adds New Colours To Aerox 155 Version S At INR 1.53 Lakh Odysse HyFy Launches At INR 42,000 For Everyday Urban Commutes KPIT Strengthens Commercial Vehicle Push With Caresoft Acquisition JSW MG Launches Windsor PRO With Bigger Battery, Advanced Tech, Flexible Ownership Safety has always been paramount in construction. But with COVID reshaping how we work construction professionals are rethinking safety programs and implementing new innovations to build a better industry Here to talk more about the topic is Kaitlin Frank, Superintendent at Dome Construction and Co-Founder of the eMOD Safety App by BuildSafely As someone who’s passionate about construction safety Kaitlin has plenty of insights to share on the safety standards and processes the industry should adopt and what we can expect as we move towards a post-pandemic world Dome Construction is a mid-sized general contractor primarily in the San Francisco Bay area and southern California My main function at Dome has evolved recently from primarily focusing on the field to training our 65 superintendents I'm working on building out a Field Bootcamp that would entail everything from onboarding our field staff to continuous training and improvement throughout our team's careers at the company This initiative emerged when we realized that our training needed to be adjusted for our field teams Our Department of Innovation and Learning has built out amazing training programs and our foundation series My goal is to make sure our training is fit for the field and make sure our field staff has training that is specific to their day to day lives I've dabbled on the innovation side of things at Dome but I kept falling back into a content creation and training role I've switched over to focus on creating a boot camp to improve our success in the field and we built it because we realized that we had a gap "Can you confirm compliance at all of our jobsites?" And the answer was not easily or quickly There was no way to see what was being done in the field and relay it back into the office A lot of safety documentation gets done on paper and it was supposed to be scanned and uploaded into a platform or folder But there's not a one-stop-shop to show things like whether every company has all their documents uploaded You may be able to do it at a project level but you definitely couldn't do it at a company level There was no transparency from the field back into the office I was spending so much of my morning chasing administrative paperwork trying to make sure that everyone had signed in and had filled out these daily safety plans Those admin tasks were preventing me from doing my job and focusing on planning to prevent safety issues This was a big enough issue for Dome that we decided to build a solution We built the app and started all of our trade partners on it We quickly began seeing all this information that we've never had visibility to before That's why we decided about two years ago that we were going to separate the companies completely I was building a yoga studio downtown and was working with an electrician who was about to retire I had worked with him for about six years at that point and we were installing a step-down transformer on an electrical panel And I came back to him because I've known him for a while his daughters were a couple of years younger than my sister and me And my father is a general contractor — he's a carpenter by trade I never wanted that phone call saying he got hurt or wasn't going to come home It moved me to watch this electrician who was about to retire and say "I've been doing this for 30 years -- I know what I'm doing But that’s the thing: it could happen to you I think a lot of our industry thinks they're lucky and they're immune to something unfortunate happening There are a lot of safety solutions out there that stop at the foreman level we need to get the entire field crew involved in safety eMOD was a way to get the entire field team involved in safety This is the opportunity for people to get up and running with safety technology before they get left behind It’s not going to be long before there's another reason to prioritize safety so it’s important for people to take action sooner rather than later "I don't care how much time and energy we put into eMOD If one more person goes home safe who might not have without eMOD I think COVID brought safety to the forefront Safety was always in the background everyone knew safety was important Everyone was so focused on time and budget and getting things done But COVID raised a lot of awareness for people. And it’s important to keep safety at the forefront because we don't know what will happen next Will there be another one in the next couple of years or 10-20 years The pandemic showed people that we have to figure out another way to work I also think this pushed companies to adopt technology One of the biggest issues we’re facing is communication — whether it be working from home or a hybrid arrangement where half of your team is at home There should be transparency about what the plan is and how we’re going to move forward It’s tough in the field because things are constantly changing I think being able to graphically explain what's going on would help How do we have conversations with people to make sure that they feel comfortable bringing things up but there's also the psychological side of things A lot of people are going to realize the psychological impacts of COVID are going to be different we've been talking internally about how we're going to roll this out and start those conversations We’re going to break that barrier with our superintendents and then break them with our internal team — including our carpenters We're at a point where everyone's trying to take safety from a paper process to a digital platform but a lot of that isn’t going to work for us until the field is at a point where they're actually giving us good data Once we get them to provide the data we need we can be proactive and use information to create more analytics One of the questions we’re looking to change and add to our platform when we fill out a daily safety form is focusing on urgency How much urgency or pressure are you under to complete your tasks today Are we going to see that there are more incidents when someone feels like they're under a lot of pressure to finish what they're doing to get to the next job What type of pressure would that put on the field I think that's the next step of where people are going I can also see more emergency alert-type systems start to emerge when disasters occur or something happens on the jobsite there are text messages that go out to people letting them know to evacuate or let us know if there are people still in the building I feel that as things progress and as we start to attract more of this data we’re going to have a stronger ability to evaluate and manage risks 2018 – BorgWarner debuts its Electro-Mechanical On-Demand (EMOD) transfer case on the 2019 Ram 1500 4x4 pickup truck Building on BorgWarner’s proven Torque-On-Demand® clutching system the new EMOD technology delivers faster response and higher torque output for better on- and off-road performance the scalable system offers easy traction calibration and integration for a variety of vehicles from small SUVs to heavy-duty pickup trucks “BorgWarner’s new EMOD transfer case features unmatched clutch control and actuation capabilities,” said Dr “BorgWarner has supplied on-demand transfer cases to Ram since 2010 We are proud to introduce our latest advancements in the next-generation Ram 1500.” The heart of BorgWarner’s new EMOD transfer case is a motor-driven rotational cam mechanism which provides both robust clutch control and range shift function The active clutch actuation technology delivers higher torque output linear clutch response and pre-emptive clutch locking torque with zero rear wheel spin the system offers the capability to hold front/rear locking torque when the ignition is off the EMOD transfer case is equipped with BorgWarner’s HY-VO® driveline chain optimized for high efficiency and durable performance BorgWarner’s latest all-wheel drive transfer case features new Electro-Mechanical On-Demand (EMOD) technology to deliver faster response and higher torque output © BorgWarner Inc. | Legal Policies & Privacy | Your Privacy Choices | Site Information | Contact a global product leader in delivering innovative and sustainable mobility solutions is furthering its business with a major North American OEM by securing extensions on two transfer case contracts for upcoming vehicle launches with new platform requirements. BorgWarner will supply two types of transfer cases including its active Electro-Mechanical On-Demand 2-Speed (EMOD) and a part-time Electric Shift-on-the-Fly 2-Speed (ESOF) transfer case Two of the OEM’s combustion and hybrid passenger truck platforms will be equipped with the EMOD and ESOF while an additional passenger truck will receive the ESOF Start of production for two of the platforms are slated for 2027 with the third expected to begin in 2028.    “We have supplied this OEM with transfer cases for its combustion and hybrid passenger truck platforms for over 40 years and we are honored to have the opportunity to once again provide our transfer cases for several of their upcoming models,” said Isabelle McKenzie “These extensions solidify our team’s reputation and the proven architecture reliability and quality of our transfer case products We’re very much looking forward to providing our valued customer with exceptional service for its vehicle platforms.” The EMOD is a high-performance active transfer case that offers faster response and pre-emptive torque management that enhances the overall safety and stability of the vehicle The heart of the EMOD is a motor driven clutch-apply system that allows for active modulation of torque distribution between the front and rear wheels based on a variety of continuously monitored vehicle parameters.  While used in several other of the OEM’s platforms this is the first time the EMOD transfer case has been adopted for this particular passenger truck platform Specifically designed to handle the rugged requirements of a part-time four-wheel drive system in a heavy-duty truck the ESOF transfer case offers a highly efficient two-wheel drive mode in conjunction with the ability to lock the vehicle into four-wheel drive while in motion It performs these functions while delivering superior noise vibration and harshness engineering and design to deliver superior performance The quick and smooth-shifting ESOF technology has a proven track record reaching its third vehicle evolution for the passenger truck platform Both transfer cases are equipped with BorgWarner’s HY-VO® driveline chain which is optimized for high efficiency and improved durability The EMOD is equipped with BorgWarner’s premium friction products and the entire family of transfer cases will be manufactured at its Seneca APPOINTMENTS AUTO EXPO 2020 COVID-19 DEALER CORNER DRIVER WELFARE GARAGE EQUIPMENT LUBES & FUELS NEXT-GEN BRIGADE SAFETY FEATURE SMART FLEETZ TYRES WOMEN OF METTLE Privacy Policy Ryan McKenna's case was mentioned at Belfast Crown Court today A drug courier caught selling cocaine and cannabis to clients of his ‘Gatsby’-dubbed boss has today narrowly avoided prison was handed an 18-month sentence suspended for three years after he pleaded guilty to possessing Class A and Class B drugs with intent to supply Receive today's headlines directly to your inbox every morning and evening Please check your inbox to verify your details Metrics details Gene drives are a genetic engineering method where a suite of genes is inherited at higher than Mendelian rates and has been proposed as a promising new vector control strategy to reinvigorate the fight against malaria in sub-Saharan Africa Using an agent-based model of malaria transmission with vector genetics the impacts of releasing population-replacement gene drive mosquitoes on malaria transmission are examined and the population replacement gene drive system parameters required to achieve local elimination within a spatially-resolved The performance of two different gene drive systems—“classic” and “integral”—are evaluated and high—corresponding to annual entomological inoculation rates of 10 and 80 infectious bites per person) and other simultaneous interventions including deployment of insecticide-treated nets (ITNs) and passive healthcare-seeking Local elimination probabilities decreased with pre-existing population target site resistance frequency increased with transmission-blocking effectiveness of the introduced antiparasitic gene and drive efficiency and were context dependent with respect to fitness costs associated with the introduced gene transmission-blocking effectiveness may be the most important to focus on for improvements to future gene drive strains because a single release of classic gene drive mosquitoes is likely to locally eliminate malaria in low to moderate transmission settings only when transmission-blocking effectiveness is very high (above ~ 80–90%) simultaneously deploying ITNs and releasing integral rather than classic gene drive mosquitoes significantly boosts elimination probabilities such that elimination remains highly likely in low to moderate transmission regimes down to transmission-blocking effectiveness values as low as ~ 50% and in high transmission regimes with transmission-blocking effectiveness values above ~ 80–90% A single release of currently achievable population replacement gene drive mosquitoes in combination with traditional forms of vector control can likely locally eliminate malaria in low to moderate transmission regimes within the Sahel higher levels of transmission-blocking effectiveness than are currently available may be required The genetic engineering of mosquito populations is a promising new vector control strategy to reinvigorate the fight against malaria and potentially lead to elimination The extent to which the generation and pre-existing presence of these resistant alleles affects the ability of introduced gene drive mosquitoes to eliminate malaria must be better quantified While adult female mosquitoes can complete their feeding cycle and lay eggs the number of eggs that progress to the larval stage is determined by the amount of larval habitat available at a given time which in turn governs the number of adult vectors that eventually emerge Mosquitoes within EMOD contain simulated genomes represented by up to 10 different loci or genes Various phenotypic traits can be assigned to different genotypes Simulated spatial region and seasonality A Spatial region and grid composed of 150 1 km-by-1 km nodes used for all simulations Colors denote the human population within each node 100 male gene drive mosquitoes were released in each of the six most populous nodes (outlined in red) which account for ~ 23% of the human population in the region B Baseline seasonal cycle of adult vector populations within the simulated area before gene drive releases in the three low (annual EIR = 10 infectious bites per person) moderate (annual EIR = 30 infectious bites per person) and high (annual EIR = 80 infectious bites per person) Sahelian transmission regimes simulated here Gene drive mosquitoes were released on July 1 of the first simulation year in all simulations ITNS were also deployed on July 1 of the first and seventh simulation years in simulations with ITNs The same seasonal profile of larval habitat space was used in all grid cells and all scenarios was varied to simulate different transmission intensities with annual entomological inoculation rates (EIR) varying between 10 infectious bites per person (reflecting a low transmission setting) to 80 infectious bites per person (reflecting a high transmission setting) Neither humans nor vectors migrate into or out of the simulated region or grid squares where humans are absent at the start of the simulation no importation of malaria from outside of the modelled area All scenarios were simulated for 8 years and 20 stochastic realizations were run for each scenario All simulations included treatment with artemether-lumefantrine (AL) for symptomatic cases Those with severe malaria cases sought treatment 80% of the time within 2 days of symptom onset cases sought treatment 50% of the time within 3 days of symptom onset Health-seeking rates are assumed to be the same for all ages covering a random 70% of the population per distribution To reflect the effects of insecticide resistance each ITN is set to have a reduced initial vector blocking efficacy of only 60% and killing rate of only 70% Both blocking and killing rates decay exponentially over time with a decay constant of 2 years and 4 years Simulations with ITN deployment alone (that is those without a gene drive mosquito release) result in elimination probabilities of zero for all transmission regimes (low and high) tested here (results are available on the accompanying website for interactive visualization of simulation output) While gene drives are most likely going to be deployed alongside other vector control interventions a scenario with no ITN deployment is chosen as a baseline scenario to help compare outcomes of deploying each intervention individually as well as in synergistic configurations The basic setup of a gene drive system for population replacement involves coupling a driver gene with an anti-malaria effector gene that prevents the mosquito from transmitting malaria multiple ways in which this can be implemented Classic and integral gene drive systems A Classic gene drive system and possible alleles where the driver can no longer recognize the target site and there is no functional drive construct non-functional drive construct allele and the second type is a mutated target site allele without a drive construct These two types of resistant alleles are considered as one group in our model B Integral gene drive system and possible alleles where the driver can no longer recognize the target site and there is no functional driver or effector gene These two types of resistant alleles are again grouped together within our model where a lethal mutation in an essential gene and target site leads to non viability are also possible; the first type is a mutated essential gene allele containing an effector or driver construct and the second type is a mutated essential gene allele that does not contain an introduced effector or driver construct As with the different types of resistant alleles these two types of loss of function alleles are considered as one group within our model the endonuclease produced from the driver mediates homing both its own gene and the effector gene the driver can autonomously home itself to the target site similar to the classic drive but the effector is separated and is driven only in the presence of the driver there are only two possible outcomes after gametogenesis; if there is resistance at the target site If there is no resistance at either the driver or effector site If there is resistance at the effector site alone if there is resistance at the driver site alone only then will the entire drive system fail as long as the effector’s target site has not developed resistance the effector gene can still be driven and passed on at super-Mendelian rates even when the driver’s target site has developed resistance if a mosquito with the effector mates with a mosquito that has the driver Because of these unique consequences of separating the driver and effector genes integral gene drive systems tend to be longer-lasting and more effective than classic systems An additional characteristic that makes IGD systems longer-lasting and more effective is careful choice of target site target sites associated with both the driver and the effector are purposely located within essential genes where most mutations that arise prove lethal and cause loss of function Mutations leading to resistance at IGD target sites are therefore relatively rare since these mosquitoes cannot survive to pass on these resistant alleles This is in contrast to classic gene drive systems in which mutations at arbitrary target sites do not tend to affect mosquito fitness or viability thus allowing resistance to develop more rapidly Here EMOD is used to simulate the release and spread of both classic and integral gene drive mosquitoes In simulations of both classic and integral gene drive releases the effects of the following parameters on likelihood of local malaria elimination are examined (defined as malaria prevalence reaching and staying at zero by the end of simulation year 7 within all spatial nodes): the probability of copying over the driver and/or effector genes in the presence of the driver gene (also known as the efficiency of the drive d); the ability of the effector gene to prevent onward malaria transmission in mosquitoes (also known as the transmission-blocking effectiveness of the effector which is equivalent in either heterozygosity or homozygosity rc); the pre-existing frequency of target site resistance alleles in the population (rr0 in the classic case; rr20 at the effector target site in the integral case); and the fitness cost associated with expressing the introduced driver and effector genes represented by an increase in vector mortality (sne in the classic case; se2 associated with the effector in the integral case) Because of the high dimensionality of the results, a website with interactive visualizations of simulation output has been created to accompany the figures in this text (Additional file 1: Fig. S2), located here: https://gene-drive.bmgf.io Website users can interactively visualize the effects of all tested parameters on elimination probabilities along with elimination timing and allele frequencies over all simulated combinations of gene drive release types Though the focus of this work is primarily on understanding the effects of tested parameters on local elimination probabilities in this text we highly encourage website users to explore the effects of tested parameters on additional malaria-related variables plotted on the website as well particularly reductions in prevalence even if elimination is not achieved Elimination probability decreases with pre-existing resistance increases with transmission-blocking and drive efficiency and is context dependent with respect to fitness costs Representative time series illustrating how elimination probabilities decrease with increasing pre-existing population target site resistance and adult vector effector frequency over increasing values of pre-existing population target site resistance frequency (rr0) Traces show the mean of 20 random seeds with the shaded areas denoting standard error Elimination probabilities (e.p.) and number of days to elimination (e.d.) are denoted in the subplot titles In the simulations corresponding to these time series classic gene drive mosquitoes were released in a moderate transmission setting (annual EIR = 30) with non-rr0 parameters set equal to the following values: drive efficiency (d) = 0.9 transmission-blocking effectiveness (rc) = 0.9 and the lower the chance of locally eliminating malaria This is likely because adult vector numbers matter more and effector frequencies matter less at lower transmission-blocking effectiveness values since the effector is already relatively pervious at higher values of transmission-blocking effectiveness decreases in effector frequency are more detrimental to malaria suppression as elimination is more dependent on the effector working well all simulations assume that the target species Anopheles gambiae is the sole malaria vector and no expansion of other malaria-transmitting species to fill the ecological niche left by a transient decrease in the original number of vectors Elimination timing after a single release of classic gene drive mosquitoes only in a moderate transmission (annual EIR = 30) regime Elimination timing (computed as the number of years taken to reach elimination starting from simulation day 0 averaged over all realizations that eliminate) over a range of transmission-blocking effectiveness (rc) pre-existing population target site resistance frequency (rr0) and mortality-enhancing effector expression fitness cost (sne) values It is important to note that Fig. 7 shows time to elimination only when elimination actually occurs appears to vary more widely at high values of phenotypic effectiveness where a higher proportion of realisations eliminate and differences in average time to elimination between different parameter sets are thus more apparent compared to random variations in elimination timing within a single set of realizations time to elimination likely varies just as widely at lower values of phenotypic effectiveness but there are just a lower proportion of simulations eliminating making it difficult to discern differences easily the same physical and biological mechanisms affecting elimination timing are at play at all values of phenotypic effectiveness even if variations in elimination timing appear larger at higher values Elimination probabilities after a single release of classic gene drive mosquitoes and ITN deployment in a moderate transmission (annual EIR = 30) regime. Same as Fig. 3 Elimination probabilities after a single release of integral gene drive mosquitoes and ITN deployment in a moderate transmission (annual EIR = 30) regime. Same as Fig. 3 Each scenario was run with 20 random seeds. In the supplements (Additional file 1: Fig. S10), the simulations that resulted in Fig. 3 were rerun using 50 seeds and found minimal differences between the two elimination probabilities here should be interpreted as trends in parameter space and not as accurate estimates for a specific set of parameter values A single release of classic gene drive mosquitoes with high transmission-blocking effectiveness is likely to locally eliminate malaria in low to moderate transmission settings When deploying ITNs together with a gene drive release increased drive efficiencies did not always increase elimination probabilities due to mismatches in timing between maximum ITN efficacy and peak effector frequency it is therefore important to accurately quantify the genetic parameters associated with a given gene drive mosquito strain of interest and time its release such that peak effector frequency coincides with both low mosquito season and maximum efficacy of other forms of traditional vector control Extensive vector surveillance before gene drive mosquito release would also be needed to accurately quantify vector population seasonality along with pre-existing target site resistance Because fitness cost effects on elimination probabilities are not uniform or easily predicted researchers and public health workers should develop a good understanding of both transmission-blocking effectiveness and fitness costs associated with their gene drive mosquito strains of interest before release Semi-field experiments and non-driving effector releases could be instrumental in achieving this goal as the translation of experimentally established fitness parameters into actual fitness burden incurred by transgenic mosquitoes in the environment is notoriously difficult Extensive vector surveillance should also be conducted after all gene drive mosquito releases to validate models and better understand complicated effects of gene drive system parameters such as fitness cost Sufficient surveillance after release can also be used to track failure rates and inform necessary adjustments to future gene drive strains or release logistics Though all four parameters tested here had some measurable effect on elimination probabilities transmission-blocking effectiveness and fitness cost may be most important to focus on for future improvements to new strains of gene drive mosquitoes due both to their outsized influence on elimination probability as well as their potentially limiting existing values Existing population target site resistances are therefore likely to be low (less than or equal to 1%) given the ability of researchers to choose a favourable site with little Cas9-impairing genetic variability elimination probabilities are not substantially reduced when drive efficiency decreases within this range and transmission-blocking effectiveness is sufficiently high (e.g. greater than or equal to ~ 90% when releasing classic gene drive mosquitoes without ITNs in a transmission regime where annual EIR = 30 and above ~ 60–70% in the same situation with ITNs) This is true for releases of classic or integral gene drive mosquitoes though the exact values of transmission-blocking effectiveness required differ depending on the gene drive system and absence or presence of other forms of vector control even at the lower end of realistic Anopheles drive efficiency values (~ 90%) elimination probabilities are generally not limited by drive transmission rates Though increasing drive efficiencies from 95 to 100% can boost elimination probabilities at lower transmission-blocking effectiveness values (along with high fitness costs and low but realistic pre-existing target site resistances) drive efficiencies of ~ 95% may be extremely difficult to improve upon with conventional mosquito engineering efforts drive transmission rate is not a high priority for further improvements due to its already high efficiency and promising ability to enable elimination along with the likely difficulty associated with bringing efficiencies even higher It would be theoretically favourable to create strains with effector expression fitness costs as low as possible since lower fitness costs allow introduced anti-pathogenic GM strains to more readily spread and compete against wild type mosquitoes fitness cost ranges required to achieve elimination are highly dependent on other parameters Assuming the presence of one primary malaria vector species and limited niche expansion by another a single release of gene drive mosquitoes with lower transmission-blocking effectiveness is more likely to eliminate malaria when associated fitness costs of effector expression are higher (up to a certain point) a release of more effective transmission-blocking gene drive mosquitoes may be increasingly likely to eliminate malaria at lower fitness costs rather than universally seeking to generate strains with reduced fitness costs researchers may opt to generate strains with optimal combinations of drive efficiency and transmission-blocking effectiveness to increase the chances of elimination in their particular setting of interest Though transmission-blocking effectiveness must always be above some minimum threshold for any population replacement gene drive release to achieve elimination there is no equivalent maximum threshold that fitness cost must be below Here fitness cost are simulated as a uniform increase in vector mortality across all ages and sexes but future work could examine the outcomes of age or sex-specific fitness effects such as a reduction in the lifespan of females only Existing population replacement gene drive mosquitoes can likely eliminate malaria in low to moderate transmission settings non-gene drive vector control strategies are essential tools in the path towards elimination because a single release of mosquitoes with currently achievable gene drive characteristics is not likely to achieve elimination on its own In a high transmission setting (annual EIR = 80) additional non-gene drive interventions become even more important transmission-blocking effectiveness values of ~ 50% lead to high probabilities of elimination only when fitness costs are within a narrow range elimination in a high transmission Sahelian setting will likely require a vast improvement to transmission-blocking effectiveness in future integral gene drive mosquito strains and/or additional layering of non-gene drive interventions beyond ITNs These other interventions could include short term strategies such as indoor residual spraying (IRS) as well as longer term approaches including housing improvement Regardless of which other interventions are utilized releasing population-replacing gene drive mosquitoes helps create a window of opportunity during which prevalence may be greatly suppressed and other tools can be ramped up to achieve elimination even when a single gene drive mosquito release by itself cannot Future work can seek to better understand how this type of evolution could affect both timing and probability of elimination probabilities though parasite resistance can also be mitigated by releasing a second set of mosquitoes with a different type of effector that would be new to the parasite only one species and pool of mosquitoes (Anopheles gambiae) has been accounted for in the simulations presented here and it was assumed that other species were either not present or did not play an appreciable role in malaria transmission If another malaria-transmitting Anopheles species were present to fill the ecological niche of the single simulated species elimination probabilities likely would not increase as substantially with higher fitness costs and reduced vector populations at low values of transmission-blocking effectiveness Future work can examine elimination probabilities in the presence of multiple malaria-transmitting Anopheles species with releases of gene drive mosquitoes corresponding to each different species Future work can also explore the effects of multiple gene drive mosquito releases over several years compared to a one-time release though human and vector migration is simulated between 1 km-by-1 km nodes within the region migration of humans or vectors into or out of the simulated region was not included While the inner nodes from the simulations serve as a proxy to study the effects of migration from outside regions to the simulated area it is likely that continued importation of malaria via humans or vectors from outside of the simulated region could have made elimination more difficult to achieve within the region across all scenarios because the gene drive systems simulated here are self-propagating genes introduced via these systems would gradually replace wild type mosquitoes in surrounding regions as well spreading into all wild-type vector populations of the same species until a barrier to vector migration and therefore gene flow is reached Most or all vector populations migrating back into the simulated region would therefore eventually have experienced their own introduction of gene drive mosquitoes as well it is not inconceivable that importation of malaria via migrating vectors into this relatively small region would gradually decrease and potentially become negligible over time In addition to the greatly reduced importation of malaria via gene drive mosquitoes from outside of the simulated region human importation of malaria into the simulated region could be greatly reduced if travelers are required to be tested before entering or returning home If a surveillance system that would detect infected human travelers is infeasible repeated releases of gene drive mosquitoes carrying alternate effectors that would result in a longer window of transmission suppression could also be used to mitigate the impact of imported malaria Future larger spatial scale (and therefore lower resolution) simulations along with incorporation of as yet unavailable additional data on both human and vector migration distances and frequencies would allow us to better resolve these dynamics This additional data on vector movements would be invaluable for better understanding the potential spatiotemporal evolution of gene drive mosquito frequencies and the resultant effects on malaria transmission in SSA Immediate future research should therefore prioritize entomological surveillance efforts The input files, model executable, and code for running simulations as well as analyzing and plotting model output can be found on Github (https://github.com/InstituteforDiseaseModeling/leung-gene-drive-2021) and the malaria-toolbox packages are available upon request from support@idmod.org World malaria report 2020—20 years of global progress & challenges The effect of malaria control on Plasmodium falciparum in Africa between 2000 and 2015 Malaria eradication within a generation: ambitious Implications of insecticide resistance for malaria vector control with long-lasting insecticidal nets: trends in pyrethroid resistance during a WHO-coordinated multi-country prospective study Mapping trends in insecticide resistance phenotypes in African malaria vectors Averting a malaria disaster: will insecticide resistance derail malaria control Challenges for malaria vector control in sub-Saharan Africa: resistance and behavioral adaptations in Anopheles populations Suppression of a field population of Aedes aegypti in Brazil by sustained release of transgenic male mosquitoes Successful suppression of a field mosquito population by sustained release of engineered male mosquitoes Open field release of genetically engineered sterile male Aedes aegypti in Malaysia Field performance of engineered male mosquitoes Efficient population modification gene-drive rescue system in the malaria mosquito Anopheles stephensi Population modification of Anopheline species to control malaria transmission Cheating evolution: engineering gene drives to manipulate the fate of wild populations Site-specific selfish genes as tools for the control and genetic engineering of natural populations Controlling malaria transmission with genetically-engineered Plasmodium-resistant mosquitoes: milestones in a model system Genetic approaches to interfere with malaria transmission by vector mosquitoes Engineered resistance to Plasmodium falciparum development in transgenic Anopheles stephensi Transgenic Anopheles stephensi coexpressing single-chain antibodies resist Plasmodium falciparum development Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite Activation of Akt signaling reduces the prevalence and intensity of malaria parasite infection and lifespan in Anopheles stephensi mosquitoes Malaria-resistant mosquitoes (Diptera: Culicidae); the principle is proven Novel CRISPR/Cas9 gene drive constructs reveal insights into mechanisms of resistance allele formation and drive efficiency in genetically diverse populations The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito Reducing resistance allele formation in CRISPR gene drive Anopheles gambiae genome conservation as a resource for rational gene drive target site selection Pathway to deployment of gene drive mosquitoes as a potential biocontrol tool for elimination of malaria in sub-Saharan Africa: recommendations of a scientific working group Promises and perils of gene drives: navigating the communication of complex Systematic identification of plausible pathways to potential harm via problem formulation for investigational releases of a population suppression gene drive to control the human malaria vector Anopheles gambiae in West Africa Requirements for driving antipathogen effector genes into populations of disease vectors by homing insecticide resistance and gene drives: an agent-based modeling approach to evaluate malaria transmission and elimination Modelling the suppression of a malaria vector using a CRISPR-Cas9 gene drive to reduce female fertility Modelling the spatial spread of a homing endonuclease gene in a mosquito population MGDrivE: a modular simulation framework for the spread of gene drives through spatially explicit mosquito populations Overcoming evolved resistance to population-suppressing homing-based gene drives Nash A, Urdaneta GM, Beaghton AK, Hoermann A, Papathanos PA, Christophides GK, et al. Integral gene drives for population replacement. Biol Open. 2018. https://doi.org/10.1242/bio.037762 Impact of mosquito gene drive on malaria elimination in a computational model with explicit spatial and temporal dynamics Epidemiological Modeling Software. Institute for Disease Modeling. 2021. http://idmod.org A malaria transmission-directed model of mosquito life cycle and ecology Seasonality and heterogeneity of malaria transmission determine success of interventions in high-endemic settings: a modeling study Center for International Earth Science Information Network. https://www.ciesin.columbia.edu/data/hrsl/ Research on the epidemiology and control of malaria in the Sudan savanna of West Africa Windborne long-distance migration of malaria mosquitoes in the Sahel Investigating the impact of enhanced community case management and monthly screening and treatment on the transmissibility of malaria infections in Burkina Faso: study protocol for a cluster-randomised trial Reducing malaria burden and accelerating elimination with long-lasting systemic insecticides: a modelling study of three potential use cases Short-term impact of mass drug administration with dihydroartemisinin plus piperaquine on malaria in Southern Province Zambia: a cluster-randomized controlled trial Landscape movements of Anopheles gambiae malaria vector mosquitoes in rural Gambia Achieving and maintaining universal coverage with long-lasting insecticidal nets for malaria control Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes Next-generation gene drive for population modification of the malaria vector mosquito A CRISPR–Cas9 gene drive targeting doublesex causes complete population suppression in caged Anopheles gambiae mosquitoes Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi A CRISPR-Cas9 gene drive system targeting female reproduction in the malaria mosquito vector Anopheles gambiae Experimental population modification of the malaria vector mosquito Transgenic Anopheles gambiae expressing an antimalarial peptide suffer no significant fitness cost Broad spectrum immunomodulatory effects of Anopheles gambiae microRNAs and their use for transgenic suppression of Plasmodium Converting endogenous genes of the malaria mosquito into simple non-autonomous gene drives for population replacement Engineered Anopheles immunity to Plasmodium infection Site-specific integration and expression of an anti-malarial gene in transgenic Anopheles gambiae significantly reduces Plasmodium infections Transgenic expression of the anti-parasitic factor TEP1 in the malaria mosquito Anopheles gambiae Toward the definition of efficacy and safety criteria for advancing gene drive-modified mosquitoes to field testing Gerardin modeling impact and cost-effectiveness of driving-Y gene drives for malaria elimination in the Democratic Republic of the Congo Download references The authors would like to thank Svetlana Titova and Clinton Collins for model and software support and Clinton Collins for the tremendous amount of work they did to help us set up the interactive visualization website This work was supported by the Gates Foundation All authors read and approved the final manuscript The authors have declared that no competing interests exist Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations unless otherwise stated in a credit line to the data Download citation DOI: https://doi.org/10.1186/s12936-022-04242-2 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Tier 1 supplier BorgWarner will debut its Electro-Mechanical On-Demand (EMOD) transfer case on the 2019 Ram 1500 4×4 pickup truck Building on the company’s Torque-On-Demand clutching system The scalable system offers easy traction calibration and integration for a variety of vehicles “BorgWarner’s new EMOD transfer case features unmatched clutch control and actuation capabilities,” said Dr Stefan Demmerle president at BorgWarner PowerDrive Systems “BorgWarner has supplied on-demand transfer cases to Ram since 2010 We are proud to introduce our latest advancements in the next-generation Ram 1500.” The heart of BorgWarner’s new EMOD transfer case is a motor-driven rotational cam mechanism which provides both robust clutch control and range shift function the EMOD transfer case is equipped with BorgWarner’s HY-VO driveline chain Learn about our scientific breakthroughs in the latest news stories Learn more about partnering with NREL's Industrialized Construction Innovation team to scale up industrialized commercialization capabilities and EMOD principles View all news and feature stories Stay connected with the latest news and research breakthroughs from NREL Listen to NREL's official podcast for biweekly snapshots of work underway at the lab Choose from a select group of photos below or view and download photos from our Image Gallery Text version Learn more about NREL's director, associate lab directors, and the leadership team NREL advances the science and 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Learn more about NREL and see facts and figures like number of partners contact a member of our media relations team The National Renewable Energy Laboratory is a national laboratory of the U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy An official website of the United States government Module is an innovative modular housing developer, with a product that is affordable, contemporary, and energy efficient. They have developed models for townhomes, duplexes, detached single-family homes, and six-unit multifamily buildings. Each home is designed with the goal of achieving the Department of Energy’s Zero Energy Ready Home certification In 2023, Module aimed to incorporate energy efficiency strategies identified in the Energy in Modular (EMOD) Buildings Method: A Guide to Energy-Efficient Design for Industrialized Construction of Modular Buildings published by the National Renewable Energy Laboratory (NREL) into their existing modular assembly process Integrating these strategies required workforce development to enable seamless transition to a highly efficient low-carbon line without affecting the cost and throughput of the existing assembly line.  NREL mapped its EMOD method strategies and modular net-zero design production practices to Module’s training needs at their Last Mile Innovation Lab and provided recommendations for specific training demonstrations.  The NREL technical assistance team developed an outline for Module’s workforce training needs particularly for air barrier and envelope insulation installation This assistance included mapping out quality assurance steps needed to verify technical installation on the factory line including recommending that each station verify their component installations independently NREL then introduced ways to document the sequences of tasks and building science elements for each stage of the modular assembly.  The ABC Collaborative provided additional support to Module Technology scaling support included strategic guidance and partnership building with relevant demand-side stakeholders and end users including Habitat for Humanity and Quartz Properties; introduction to multiple venture capital firms including VoLo Earth; and development of a value messaging framework and pitch deck The ABC Collaborative also advised Module on specific space-conditioning strategies and materials to consider for their product lines These developments helped Module prepare for their connection with the University of Pittsburgh Medical Center which invested $1 million in Module to support affordable housing developments in Pittsburgh to ease the homelessness crisis and reduce negative health effects associated with homelessness “This was our first project with NREL and a very productive one,” said Ankur Dobriyal “The ability of the technical assistance team to identify key parameters affecting different parts of the construction process is unparalleled We also collaborated on identifying key assemblies that affect building performance based on NREL’s EMOD guide It helped our team think deeply and through different approaches to tackle modular construction-specific performance and installation challenges “We would welcome the chance to continue collaborating with NREL with the Last Mile Facility now up and running Any future work and inputs will directly benefit a pipeline of affordable housing projects in disadvantaged communities We are also working with the local trade institute on job training and employment opportunities for when the facility reaches scale This would be the perfect opportunity for further work together.” Render of Last Mile Facility Innovation Lab envisioned by Module + NREL The sequencing documentation for the modular assembly that NREL created will be used to develop curriculum for Module’s next phase of workforce training development.  These improvements to Module’s workforce training approach will enable the modular manufacturer to streamline compliance with Zero Energy Ready Home specifications moving forward This work has produced collaborative action items between Module and NREL some of which were presented at the World of Modular conference in 2024 Technical assistance is available to help enhance the performance, productivity, energy efficiency, and carbon savings of your industrialized construction project. Contact abc@ee.doe.gov to learn more.  The ABC Collaborative brings together a diverse network of incumbent and emergent buildings sector actors across manufacturing The Collaborative works to accelerate the uptake and mainstream adoption of ABC while supporting—and leveraging—modernization of the U.S Interested in learning more or joining? Contact the ABC Collaborative here integrates energy efficiency and advanced technology solutions into industrialized construction processes to drastically increase the speed and scale of high-performance low-carbon building retrofits and new construction Metrics details As both mechanistic and geospatial malaria modeling methods become more integrated into malaria policy decisions there is increasing demand for strategies that combine these two methods This paper introduces a novel archetypes-based methodology for generating high-resolution intervention impact maps based on mechanistic model simulations An example configuration of the framework is described and explored dimensionality reduction and clustering techniques were applied to rasterized geospatial environmental and mosquito covariates to find archetypal malaria transmission patterns mechanistic models were run on a representative site from each archetype to assess intervention impact these mechanistic results were reprojected onto each pixel to generate full maps of intervention impact The example configuration used ERA5 and Malaria Atlas Project covariates and the Institute for Disease Modeling’s EMOD model to explore a range of three-year malaria interventions primarily focused on vector control and case management and mosquito abundance layers were clustered into ten transmission archetypes with distinct properties Example intervention impact curves and maps highlighted archetype-specific variation in efficacy of vector control interventions A sensitivity analysis showed that the procedure for selecting representative sites to simulate worked well in all but one archetype This paper introduces a novel methodology which combines the richness of spatiotemporal mapping with the rigor of mechanistic modeling to create a multi-purpose infrastructure for answering a broad range of important questions in the malaria policy space It is flexible and adaptable to a range of input covariates and mapping strategies and can be adapted to the modelers’ setting of choice Malaria is one of humanity’s oldest and most insidious ailments, co-evolving with mosquitoes and humans over millions of years [1] combined with its complex transmission pathways makes malaria a uniquely heterogeneous and environmentally sensitive disease Understanding malaria in a given location requires not just an understanding of human behavior but also a detailed knowledge of resident mosquito species and their behavior and the seasonal patterns of the landscape Computational modeling and malaria policy have been linked since the 1950s from seminal pen-and-paper equations by Ronald Ross and George Macdonald to today’s detailed computational models capable of simulating individual humans The fundamental goal of these models is to help decision-makers craft a malaria strategy that aligns with the epidemiological Mechanistic and spatiotemporal models serve complementary purposes in malaria Spatiotemporal models elucidate the past and present of disease burden and related metrics which mechanistic models can then use for insight into the future while mechanistic models contribute causal structure and exploration of counterfactual or hypothetical scenarios As both modeling methods have grown in popularity and demand there is increased interest in products that combine the two approaches allowing for a spatially and temporally detailed exploration of the consequences of different policy decisions these statistical methods crucially lack the explicit causal relationships that allow mechanistic models to effectively test the consequences of different policies and transmission intensity spatial covariates into three and ran simulations on all possible combinations of these groups before re-projecting onto the pixel level This exhaustive strategy does not take advantage of the spatial relationships between different covariates which could reduce computational burden and generate more informative cluster properties The methodology presented in this paper leverages the strength of both mechanistic and spatiotemporal methods to allow computationally-feasible generation of high-resolution maps that reflect mechanistically modeled scenarios This process generates a range of archetypal seasonal and entomological profiles that can be useful for exploratory data analysis while also generating an explicit link between these profiles and any given location across Africa This mapping capacity provides a computationally efficient pathway for presenting results geospatially and in terms of expected burden change high-dimensional spatial covariates and machine learning methods are harnessed to generate a small number of spatially-explicit “archetypes” of malaria transmission characterized by their covariate similarity mechanistic models are run on a representative site from each archetype spatial data and model results create a lookup table through which maps of intervention impact are generated This approach is appealing for its flexibility but requires a number of specific decisions that can materially impact results Which algorithm should be used for dimensionality reduction Which algorithm should be used for clustering and how should the number of clusters be determined When clustered results are being used as inputs for mechanistic models and subsequent generation of new maps How should representative sites be selected from each cluster Which mechanistic model should be used to assess intervention impact How should results from representative sites be reprojected back onto other members of the group and the version presented here represents a validation check to ensure that similar results arise from a more in-depth approach A sensitivity analysis exploring the representativeness of a given “representative site” is also described The primary goal of this document is to introduce a novel modeling paradigm in sufficient detail to be adapted for other use cases the terms “archetypes strategy” and “archetypes framework” will be used to describe the general methodology of using dimensionality reduction and clustering to locate a subset of sites appropriate for mechanistic modeling The term “example configuration” will be used to describe the specific set of choices within the broader strategy that are shown here for demonstration The archetypes strategy is flexible and generalizable to any covariate set The methods sections are subdivided into a general discussion and an explicit description of the example configuration parameters The results section focuses on describing example configuration outcomes the discussion section highlights lessons learned and other use cases of this archetypes framework each of the six methodological questions described in the introduction is explored in detail followed by a description of the specific choices made in the example configuration The covariates used for clustering should be selected mindfully to capture the types of variation to which the transmission model is most sensitive these should almost always include covariates that capture the different seasonality patterns of different malaria-endemic regions as this directly impacts disease seasonality For models that explicitly simulate different mosquito behaviors by species covariates describing relative species abundance are also valuable Baseline malaria transmission intensity is another useful source of input data The example configuration described below intentionally excluded it from the clustering process instead running simulations for each archetype over a range of transmission intensities Other possible covariates of interest include intervention history Covariate data must geographically cover the region of interest and should be utilized on the same spatial resolution as the final results Covariate data for malaria will often also include a temporal component showing either seasonality or secular time Covariates are collected into a “stack” of spatial or spatiotemporal input files measuring different metrics on different scales It is important to normalize or rescale these covariates prior to performing dimensionality reduction to avoid an artificial effect due to differently-scaled inputs a decision must be made regarding the relative weight of different inputs clustering covariates included 12 rainfall layers and three mosquito species relative abundance layers These covariates were not differentially weighted prior to dimensionality reduction meaning that the rainfall and temperature layers had a stronger impact on results than the mosquito abundance layers This choice was acceptable for the work at hand but different circumstances might encourage different weighting Environmental covariate data on rainfall and air temperature were sourced from the ERA5 project (https://www.ecmwf.int/en/forecasts/datasets/reanalysis-datasets/era5) a global reanalysis that generates internally-consistent estimates for a wide range of climate parameters across the globe monthly mean total precipitation and 2-meter air temperature from 2000 to 2018 were downloaded Monthly means were averaged across the time series to generate synoptic 12-month trends Because ERA5 spatial resolution is 0.25\(^\circ\)-by-0.25\(^\circ\) (approximately 30km-by-30km at the equator) covariates were resampled down to the 5km-by-5km level and realigned to match MAP’s standard spatial specifications Distribution of covariates for Singular Value Decomposition (SVD) across all pixels before and after rescaling Synoptic monthly mean temperature (degrees C) and rainfall (mm/month) are from the ERA5 project tracks the proportion of Anopheles arabiensis If the covariate selection process only locates a few variables of interest a dimensionality reduction step may not be necessary beyond the point that covariates can comfortably be plotted together (four or five layers at most) dimensionality reduction can be a valuable tool both for data exploration and for more effective clustering The goal of these techniques is to collapse high-dimensional data into a lower-dimensional space in a way that preserves as much of the original data variation as possible creating a denser and richer database from a sparser one A wide range of dimensionality reduction techniques are available in machine learning software packages Proportion of variance explained by the first five singular vectors after singular value decomposition (SVD) The first three vectors were retained for clustering analysis including many excellent tutorials for beginners clustering strategies are unsupervised learning methods that group data points together based on proximity in all provided dimensions K-means elbow plot for k between 3 and 15. The x-axis shows cluster count, while the y-axis shows the proportion of total data variance that is captured by between-cluster variance in each setting. A cluster count of ten (vertical blue line) was chosen for further analysis K-means results. Top and side view of pixel values reprojected onto the first three singular vectors, after k-means clustering with a k of ten. Colors refer to different clusters and match subsequent ten-cluster plots. Black dots indicate true cluster centroids, while dark grey dots show procedurally-selected representative sites Cluster maps for k of 3 to 14. Black crosses indicate procedurally-generated representative sites (the pixels closest to cluster centroids) Maps and time series for the ten-site setting solid colored lines represent the median across the archetype shaded areas indicate the interquartile range and colored dotted lines indicate the 95% variance interval Solid black lines represent the procedurally-selected climate values of the representative site for each archetype also indicated as black crosses on the map Doughnut plots show the relative vector abundance of the representative sites K-means was applied using the kmeans command in the stats R package version 4.0.5 See the Results section for a more in-depth description of k-means outputs as there is generally a trivial distance between the true cluster centroids and their nearest data point A sensitivity analysis was conducted to assess the acceptability of this approach The data point closest to each cluster centroid (determined using k-Nearest Neighbors with k set to one) was selected as the site whose input data would be used for simulation K-nearest neighbors was applied using the get.knn command in the FNN R package version 1.1.3 a single centrally-located point is used as a proxy for all other locations in that cluster A sensitivity analysis was conducted to assess how other locations in each cluster behaved under the same intervention scenarios Ten pixels were randomly chosen from each cluster and all intervention scenarios were re-run on these 100 points in the same way that they were on the original ten Results were compared to those from the cluster centroid sites alone to assess within-cluster variance Modelers should have a close familiarity with their model of choice prior to embarking on the exercises described in this document it is necessary to understand the input parameters to which each model is most sensitive and how this sensitivity impacts covariate and archetype selection; how to appropriately parameterize each site’s demographics and interventions; and how to run checks to diagnose unexpected model behavior before acting upon any conclusions from model results modelers will utilize values from the clustering covariates for some model inputs but must choose how to initialize all variables not included in the clustering covariates the clustering analysis provided input rainfall this analysis held most other variables static across all sites and ran simulations at a range of initial transmission intensities but different use cases might call for different input parameters in different representative sites Simulations were initialized by running one 39-year intervention-free simulation for each of 25 initial transmission intensities and 10 random seeds generating a collection of 250 baseline populations upon which to test intervention impact Transmission intensities were varied by scaling mosquito larval habitat capacity which linearly impacts the number of adult mosquitoes and the level of malaria transmission in the absence of interventions The intervention-free immunity establishment period should approximate the length of a human life A 39-year period was selected because this is the duration of time for which climate data was available from ERA5 Ten is a common choice for number of random seeds to test in EMOD and has been shown to cover the variation in most parameters well Twenty-five transmission intensities were chosen to thoroughly cover variability in this important parameter One hundred fifty-two different intervention packages were tested and vaccine-based malaria prevention strategies These intervention parameters were originally part of a project to test eradication feasibility in best-case scenarios and therefore often represent coverage levels or policies more rigorous than those commonly in use today (for example mass bednet campaigns every year instead of every three years) and its efficacy assessed by mean Plasmodium falciparum parasite rate among 2–10 year-olds (\(PfPR_{2-10}\)) in the final year of the intervention compared to the final year of the intervention-free simulation The intervention-free simulations to establish population immunity were run using climate data from 1980 to 2018 and the three-year intervention simulations were run using climate data from 2016 to 2018 Once model simulations have run for each archetype’s representative site these individual-site results must be reprojected back onto pixel level results The methodology described below constructs a lookup table to convert from baseline per-pixel transmission to intervention-impacted transmission in each archetype If transmission intensity was included as a clustering covariate the lookup table approach would differ in its details but be similar in essence maps of intervention coverage were reconstructed as follows a pixel-level map of Plasmodium falciparum prevalence among children aged 2–10 (\(PfPR_{2-10}\)) was selected from the Malaria Atlas Project Because these EMOD simulations were initiated from intervention-free scenarios the MAP estimate of \(PfPR_{2-10}\) in 2000 was selected as a proxy for malaria prevalence in the absence of any interventions for each intervention scenario and each pixel p in the selected map The archetype a to which the pixel p belongs was identified; A spline was generated between data points of initial and final \(PfPR_{2-10}\) across all transmission intensities in archetype a; This spline was used to map the initial \(PfPR_{2-10}\) corresponding to that of pixel p and archetype a to the final \(PfPR_{2-10}\) in that intervention scenario; This final \(PfPR_{2-10}\) was logged as the “intervention impact” of pixel p This allows for the reconstruction of maps hypothesizing the potential impact of different interventions across the continent Presented here are the results of the example configuration Both rainfall and mosquito vector abundance show peaks near zero and one while temperature peaks most strongly in the center of the distribution Black dots represent true cluster centroids while gray dots indicate representative sites The shape of this data is roughly circular or toroidal with those sites that have appreciable numbers of mosquitoes and rainfall comprising the edges of the circle and only the low-rainfall low-mosquito-count lime green vector clustering near the origin Visual examination shows that the ten-cluster k-means differentiates several distinct groups but may combine some groups that are visually fairly distinct such as the two lobes of the turquoise cluster (Cluster 4) ITN: Insecticide-treated net; IRS: Indoor residual spraying; AL CM: Artemether-Lumefantrine case management; ATSB: Attractive targeted sugar bait Figure 7 shows example impact curves for each archetype under different intervention scenarios as well as their translation into maps of predicted impact The impact curves show pre-intervention malaria prevalence on the x-axis and malaria prevalence after three years of interventions on the y-axis indicates no change between initial and final prevalence while the colored curves show simulation results across the range of transmission intensities More effective intervention packages have curves that swing farther toward the lower right corner of the plots Sensitivity of sites to biting intensity for vector control vs non-vector-control interventions each line represents an archetype’s representative site colored according to its indoor biting percentage as determined by its mosquito species mix The left panel shows an intervention setting with 80% coverage of insecticide-treated nets and indoor residual spraying is much more effective in areas with a higher percentage of bites occurring indoors The right panel demonstrates the inverse property: under an intervention package that includes only anti-malarial drugs and therefore does not directly target mosquitoes at all there is no differential impact across indoor biting intensities Sensitivity analysis sites. Black crosses indicate the location of all 100 reqpresentative sites used for sensistivity analysis Sensitivity analysis example intervention curves for an intervention package of 40% ITN coverage and 20% coverage with artemether-lumefantrine case management The impact curve of each archetype’s representative site is plotted in color and the curves of the ten randomly-selected sites are shown in black Shaded areas represent variation across the ten random seeds run for each site If the representative sites were effective proxies for their archetypes the colored lines and shaded areas would cover all or most of the black lines and shaded areas Mechanistic models are versatile tools for malaria intervention planning but deploying them over large geographic areas at a useful spatial resolution poses both theoretical and computational challenges This paper introduces a flexible and customizable archetypes-based framework that harnesses the richness of available spatial data and spatiotemporal modeling products to assess potential intervention impact across a range of settings and discusses key decision points to consider when constructing such a framework It includes a detailed example of how the framework might be configured This example configuration demonstrates that dimensionality reduction and clustering can identify meaningfully different environmental archetypes that the mechanistic model behaves as expected in relation to intervention effect and mosquito bionomics that the creation of new maps showing intervention impact can highlight interventions and areas of interest and that the representative sites selected can appropriately represent each archetype as a whole The demonstrative analysis used the EMOD mechanistic model and malaria risk surfaces from the Malaria Atlas Project but this methodology could just as easily be applied with different modeling software or malaria risk estimates The choice of covariates upon which to cluster is likewise arbitrarily modifiable noting that the mechanistic model used should have the capacity to accurately reflect any covariate variation that distinguishes archetypes from one another The first approach is simple and straightforward but suffers from arbitrary selection and the inability to claim that the sites shown are actually representative of other areas requires an unnecessary computational burden An archetypes-based strategy provides a useful middle ground providing a relatively streamlined computational infrastructure for projects that require national or continental coverage while also offering a useful suite of example settings that can easily be used for any type of exploratory simulation analysis This observation lends confidence to the effectiveness of both the archetypes framework and other seasonality detection methods An archetypes-based approach to intervention impact planning has several limitations When utilized without fitting to field data this method is useful as an intuition-building tool but should not be used to inform specific decisions in particular geographic locations While the ability to project results from the analysis to an arbitrarily fine spatial scale may be useful for highlighting heterogeneities such results might convey an unintended sense of confidence in the sensitivity and specificity of results It is best to consider this framework as a strategy for obtaining informative priors rather than as a way of generating quantitiatively rigorous model results these concerns fade when the strategy is utilized as a precursor to more formal model fitting The example configuration specifically has additional limitations While the selected covariates cover many environmental model sensitivities no human-centered or malaria intervention history covariates were included While some covariate standardization was performed a limited number of rescaling or standardizing approaches were conducted while common heuristics were utilized to select singular vector and cluster counts in SVD and k-means a full and formal sensitivity analysis of these heuristics has yet to be conducted These would include running k-means with more or fewer singular vectors and repeating the clustering analysis with k-fold data holdouts Both of these tests would check how cluster membership changes in response to these varied initial conditions especially for pixels on the borders between archetypes the robustness of cluster assignment between different k-values provides some confidence that such sensitivity checks would support the choices made in this analysis While the EMOD modeling software has been extensively vetted and tested it has not undergone a parameter-by-parameter sensitivity analysis to conclusively determine which variables are most robust to model changes Because the example configuration focused on hypothetical scenarios rather than prediction or projection A full uncertainty propagation strategy would begin with covariate uncertainty and reflect both mechanistic model parameter uncertainty and uncertainty in the prevalence maps used as baseline metrics The example configuration additionally does not consider a number of important malaria-related factors but could easily be extended to take them into account Future work will also include model comparison exercises between the archetypes framework and models that have been finely calibrated to specific locations to assess what improvements can be made in archetype-level predictions (while continuing to acknowledge that superseding site-specific analysis is not and will not be the goal) but this framework can also be extended to malaria-endemic regions of Asia and the Americas This paper presents a novel archetypes-based strategy for high-resolution large-area malaria intervention impact assessment lends itself well to more detailed calibration-based approaches and guides intuition in data-sparse settings It has already proved a useful tool in the malaria modeling repertoire and the authors look forward to further expanding its utility to new use cases and stakeholder needs Dihydroartemisinin-Piperaquine case management Plasmodium falciparum parasite rate among children aged 2–10 The making of a tropical disease: a short history of malaria Baltimore: Johns Hopkins University Press; 2011 2000–17: a spatial and temporal modelling study A long neglected world malaria map: Plasmodium vivax endemicity in 2010 Mapping the global endemicity and clinical burden of Plasmodium vivax Developing global maps of the dominant anopheles vectors of human malaria Sinka ME, Golding N, Massey NC, Wiebe A, Huang Z, Hay SI, et al. Modelling the relative abundance of the primary African vectors of malaria before and after the implementation of indoor, insecticide-based vector control. Malaria J. 2016;15:142. https://doi.org/10.1186/s12936-016-1187-8 Coverage and system efficiencies of insecticide-treated nets in Africa from 2000 to 2017 Maps and metrics of insecticide-treated net access and nets-per-capita in Africa from 2000–2020 Global estimation of anti-malarial drug effectiveness for the treatment of uncomplicated Plasmodium falciparum malaria 1991–2019 Global maps of travel time to healthcare facilities Walker PGT, Griffin JT, Ferguson NM, Ghani AC. Estimating the most efficient allocation of interventions to achieve reductions in P. falciparum malaria burden and transmission in Africa. Lancet Glob Health. 2015. https://doi.org/10.1016/S2214-109X(16)30073-0 Modelling the cost-effectiveness of mass screening and treatment for reducing Plasmodium falciparum malaria burden Stuckey EM, Smith TA, Chitnis N. Estimating malaria transmission through mathematical models. Trend Parasitol. 2013;29:477–82. https://doi.org/10.1016/j.pt.2013.08.001 Smith NR, Trauer JM, Gambhir M, Richards JS, Maude RJ, Keith JM, et al. Agent-based models of malaria transmission: a systematic review. Malaria J. 2018. https://doi.org/10.1186/s12936-018-2442-y Spatial mapping with Gaussian processes and nonstationary Fourier features Spatial analysis made easy with linear regression and kernels Griffin JT, Hollingsworth TD, Okell LC, Churcher TS, White M, Hinsley W, et al. Reducing Plasmodium falciparum malaria transmission in Africa: a model-based evaluation of intervention strategies. PLOS Med. 2010;7: e1000324. https://doi.org/10.1371/journal.pmed.1000324 Elucidating ecological complexity: unsupervised learning determines global marine eco-provinces Exploiting sparsity and equation-free architectures in complex systems Low-dimensional procedure for the characterization of human faces Malaria eradication: benefits, future scenarios & feasibility. A report of the Strategic Advisory Group on Malaria Eradication. 2020. https://www.who.int/publications/i/item/9789240003675 Eckart C, Young G. The approximation of one matrix by another of lower rank. Psychometrika. 1936;1:211–8. https://doi.org/10.1007/BF02288367 Singular value decomposition for genome-wide expression data processing and modeling Xu D, Tian Y. A comprehensive survey of clustering algorithms. Ann Data Sci. 2015;2:165–93. https://doi.org/10.1007/s40745-015-0040-1 Clustering algorithms: a comparative approach Some: methods for classification and analysis of multivariate observations Mathematical modeling of the impact of malaria vaccines on the clinical epidemiology and natural history of Plasmodium falciparum malaria: Overview Kiware SS, Chitnis N, Tatarsky A, Wu S, Castellanos HMS, Gosling R, et al. Attacking the mosquito on multiple fronts: insights from the vector control optimization model (VCOM) for malaria elimination. PLoS ONE. 2017;12: e0187680. https://doi.org/10.1371/journal.pone.0187680 Public health impact and cost-effectiveness of the RTS S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models Guelbéogo WM, Gonçalves BP, Grignard L, Bradley J, Serme SS, Hellewell J, et al. Variation in natural exposure to anopheles mosquitoes and its effects on malaria transmission. eLife. 2018. https://doi.org/10.4269/ajtmh.2006.75.2_suppl.0750001 Vaisala. HUMIDITY CONVERSION FORMULAS Calculation formulas for humidity; 2013. www.vaisala.com WHO—High burden to high impact: a targeted malaria response Present and future Köppen-Geiger climate classification maps at 1-km resolution McCarthy KA, Wenger EA, Huynh GH, Eckhoff PA. Calibration of an intrahost malaria model and parameter ensemble evaluation of a pre-erythrocytic vaccine. Malaria J. 2015;14:6. https://doi.org/10.1186/1475-2875-14-6 Download references The authors would like to thank all members of the WHO Strategic Advisory Group for Malaria Elimination and the Lancet Commission on Malaria Eradication for their support This publication is based on research conducted by the Malaria Atlas Project and funded in whole or in part by the Bill & Melinda Gates Foundation including models and data analysis performed by the Institute for Disease Modeling at the Bill & Melinda Gates Foundation by the Bill & Melinda Gates Foundation (OPP1197730) Under the grant conditions of the Foundation a Creative Commons Attribution 4.0 Generic License has already been assigned to the Author Accepted Manuscript version that might arise from this submission This work was also supported by the Telethon Trust Department of Preventive Medicine and Institute for Global Health MRC Centre for Global Infectious Disease Analysis Department of Infectious Disease Epidemiology JLP contributed to the design of the machine learning infrastructure MW and DH wrote a tool to convert ERA5 data into model input files ABV wrote the first draft of the manuscript and approved the final version for submission All authors read and approved the final manuscritpt The authors declare that they have no competing interests The plots below show maps and covariate summaries for cluster counts of three to 14 solid colored lines represent the median across the archetype and dotted lines indicate the 95% variance interval Solid black lines represent the climate values of the representative site for each archetype Doughnut plots show the relative vector abundance of the representative sites Absent doughnuts indicate no mosquitoes in that site EMOD (https://idmod.org/documentation) is an individual-based stochastic mechanistic modeling software developed by the Institute for Disease Modeling While EMOD is capable of modeling a number of infectious diseases only the malaria framework is described in detail here EMOD simultaneously tracks multiple simulation layers including but not limited to: mosquito habitat and life cycle and malaria interventions that disrupt any of the aforementioned layers humans are modeled as individuals while mosquitoes are modeled as cohorts though there are options to model mosquitoes individually for extremely small-scale simulations most input parameters are defined via probability distributions which are sampled at the appropriate points Spatially distinct communities can be defined While some heterogeneity in risk and behavior can be imposed within communities under most circumstances a community behaves as a well-mixed population While various types of human movement between communities can be specified in the model this analysis did not allow for human movement to keep the effects of any one archetypal site clear Due to the uncertain pathway from severe malaria to death malaria-specific mortality was not enabled in this anlaysis all individuals are immunologically naive to malaria (though a few individuals are initialized as having an active infection) EMOD is typically run with no interventions for several decades at which point the simulation state can be “frozen” a range of different intervention scenarios can be initialized Malaria interventions EMOD offers a wide range of malaria interventions in which the user can specify intervention timing Interventions function by altering default model probabilities– for example giving an individual an insecticide-treated net would reduce their probability of being bitten by a mosquito indoors while receiving antimalarial drugs after infection would alter intrahost immune parameters which would lower the likelihood of a mosquito acquiring gametocytes and increase the rate of recovery from clinical disease Table 3 presents brief descriptions of the malaria interventions used in this analysis See Table 4 Download citation DOI: https://doi.org/10.1186/s12936-023-04535-0 Note: Drivers from Corpus Christi unless otherwise noted South Texas Speedway: Gilbert Perez III, John Wayne Wilson sweep weekend events South Texas Speedway: Maupin, Rye snag USRA Limited Modified victories Ahmed Emod Elsaed Elmola (27), of Maymount Street in east Belfast, was handed an 18 month sentence suspended for three years after he pleaded guilty to possessing Class A and Class B drugs with intent to supply. Co-accused Mohammed Osman (28), of Jocelyn Street in east Belfast, pleaded guilty to possessing criminal property and received an eight month sentence suspended for 18 months. Belfast Crown Court heard how police observed Elmola’s car in Broughton Gardens off the Ravenhill Road at around 9 pm on August 13, 2021, where a cash transaction took place between driver Elmola and a male pedestrian. It was the prosecution case that police searched the car and discovered under the driver’s seat bags of cannabis weighing in total 31.8 grams along with ‘deal bags’ of cocaine weighing 6.55 grams. Osman, who was the front seat passenger in the car, was found to have cash totalling £1,421.23p. Their mobile phones were seized and a forensic examination revealed 271 WhatsApp text messages between Elmola and his drug supply boss who called himself “Gatsby”. These were described as “persistent messaging’' on August 12 and August 13, 2021, between courier Elmola and “Gatsby”who was directing the defendant to deliver drugs to certain addresses and collect money for the deals. Defence lawyer Sean O’Hare said that at the time of his offending, Elmola was suffering from both addiction and mental health issues along with financial difficulties. Jonathan Browne, defence barrister for Osman, said his client received a phone call from a third party that he was to be collected by Elmola and he had never met him before or had any contact with him previously. “There is no evidence to suggest that Osman was involved in dealing drugs in any respect,’’ added Mr Browne. Passing sentence, Judge Richard Greene KC told Elmola: “You were aiding and abetting a person who stood to gain financially from this illegal drug activity. “If there are not people prepared to deliver drugs, collect cash and return the cash to those who stood gain financially, this activity would be much more difficult to carry out. “You clearly knew what you were doing. You were a willing participant in the supply of Class A drugs. “But you have learned you lesson it would seem and you have taken steps to distance yourself from your criminal peers and you have taken efforts to improve your prospects and general circumstances which favours rehabilitation as opposed to immediate custody.’’ The judge said Osman pleaded guilty to a “type of laundering offence’' in that he had on his person around £1,400 in cash which was the proceeds of crime. “It is not entirely clear what those proceeds are. It seems to me a very significant inference that could be drawn that this money was the proceeds of drug dealing,’’ said Judge Greene. “I strongly suspect that the money you had was the proceeds of drug dealing but I can’t draw that conclusion to the requisite standard.’’ Facebook pageTwitter feedRSS feed@2025 The Irish News Ltd is furthering its business with a major North American OEM by securing extensions on two transfer case contracts for upcoming vehicle launches with new platform requirements BorgWarner will supply two types of transfer cases Two of the OEM's combustion and hybrid passenger truck platforms will be equipped with the EMOD and ESOF "We have supplied this OEM with transfer cases for its combustion and hybrid passenger truck platforms for over 40 years and we are honored to have the opportunity to once again provide our transfer cases for several of their upcoming models," said Isabelle McKenzie "These extensions solidify our team's reputation and the proven architecture We're very much looking forward to providing our valued customer with exceptional service for its vehicle platforms." and pre-emptive torque management that enhances the overall safety and stability of the vehicle The heart of the EMOD is a motor driven clutch-apply system that allows for active modulation of torque distribution between the front and rear wheels based on a variety of continuously monitored vehicle parameters  While used in several other of the OEM's platforms Both transfer cases are equipped with BorgWarner's HY-VO® driveline chain The EMOD is equipped with BorgWarner's premium friction products and the entire family of transfer cases will be manufactured at its Seneca BorgWarner has been a transformative global product leader bringing successful mobility innovation to market Forward-Looking Statements: This press release contains forward-looking statements as contemplated by the 1995 Private Securities Litigation Reform Act that are based on management's current outlook Words such as "anticipates," "believes," "continues," "could," "designed," "effect," "estimates," "evaluates," "expects," "forecasts," "goal," "guidance," "initiative," "intends," "may," "outlook," "plans," "potential," "predicts," "project," "pursue," "seek," "should," "target," "when," "will," "would," and variations of such words and similar expressions are intended to identify such forward-looking statements other than statements of historical fact contained or incorporated by reference in this press release that we expect or anticipate will or may occur in the future regarding our financial position business strategy and measures to implement that strategy expansion and growth of our business and operations references to future success and other such matters such as those described under the heading "Critical Accounting Policies and Estimates" in Item 7 of our most recently-filed Annual Report on Form 10-K ("Form 10-K") All forward-looking statements are based on assumptions and analyses made by us in light of our experience and our perception of historical trends current conditions and expected future developments as well as other factors we believe are appropriate under the circumstances Forward-looking statements are not guarantees of performance and the Company's actual results may differ materially from those expressed projected or implied in or by the forward-looking statements You should not place undue reliance on these forward-looking statements which speak only as of the date of this press release Forward-looking statements are subject to risks and uncertainties many of which are difficult to predict and generally beyond our control that could cause actual results to differ materially from those expressed and tax regimes; the supply disruptions impacting us or our customers such as the current shortage of semiconductor chips that has impacted original equipment manufacturer ("OEM") customers and their suppliers including us; commodities availability and pricing and an inability to achieve expected levels of success in additional commercial negotiations with customers concerning recovery of these costs; competitive challenges from existing and new competitors including OEM customers; the challenges associated with rapidly changing technologies particularly as relates to electric vehicles and our ability to innovate in response; uncertainties regarding the extent and duration of impacts of matters associated with the COVID-19 pandemic including additional production disruptions; the difficulty in forecasting demand for electric vehicles and our electric vehicles revenue growth; potential disruptions in the global economy caused by Russia's invasion of Ukraine; the ability to identify targets and consummate acquisitions on acceptable terms; failure to realize the expected benefits of acquisitions on a timely basis including our recent acquisitions of AKASOL AG the anticipated acquisition of Hubei Surpass Sun Electric's charging business and our 2020 acquisition of Delphi Technologies PLC; the failure to promptly and effectively integrate acquired businesses; the potential for unknown or inestimable liabilities relating to the acquired businesses; our dependence on automotive and truck production both of which are highly cyclical and subject to disruptions; our reliance on major OEM customers; fluctuations in interest rates and foreign currency exchange rates; our dependence on information systems; the uncertainty of the global economic environment and potential for recessionary conditions in regional economies; the outcome of existing or any future legal proceedings including litigation with respect to various claims; future changes in laws and regulations in the countries in which we operate; impacts from potential future acquisition or disposition transactions; and the other risks noted in reports that we file with the Securities and Exchange Commission "Risk Factors" in our most recently-filed Form 10-K and/or Quarterly Report on Form 10-Q We do not undertake any obligation to update or announce publicly any updates to or revisions to any of the forward-looking statements in this press release to reflect any change in our expectations or any change in events (NYSE: BWA) announces the following Webcast: What: BorgWarner 2025 First Quarter Results Conference Call When: May 7 BorgWarner is set to showcase its latest technology at the 46th Vienna Motor Symposium from May 14-16 Supply Chain/Logistics Supply Chain/Logistics General Manufacturing General Manufacturing a pioneer in Turnkey and Offsite Modular Manufacturing a special purpose acquisition company focused on innovative technology firms proudly announce the execution of a definitive business combination agreement (the "Transaction") The transformative merger is poised to position Eco Modular as a publicly traded company on NASDAQ under the Ticker Symbol EMOD The anticipated closing is set for the first quarter of 2024 subject to regulatory approvals and customary closing conditions Capitalizing on Sustainable Construction Practices in a Growing Market With a surge in global population projected to double the number of buildings over the next 30 years modular construction emerges as a sustainable solution to claim a significant share of the $373 billion US and European construction market by 2030 This approach not only promises substantial annual cost savings of up to $22 billion but also aligns with Environmental making it a key driver of positive change in the industry combining its established business with Ecohouse Developments a pioneering force in the modular construction sector has successfully delivered over 7,000 single Modular Accessory Dwelling Units (ADUs) The company operates two cutting-edge manufacturing facilities in Eastern Europe employing Structured Insulated Panels technology to ensure efficient and high-standard construction Eco Modular's comprehensive approach encompasses the production with strategic showrooms in the UK and Europe Eco Modular is achieving remarkable success The company's short-term strategy involves doubling production capacity and intensifying sales efforts to achieve a goal of over 500 units a month in the UK and Europe Eco Modular's M&A strategy in the UK aims to enhance its market presence and customer base for Accessory Dwelling Units Eco Modular is strategically focused on the expansion of its Ecohouse facility in Eastern Europe aligning with the escalating demand for modular Accessory Dwelling Units (ADUs) Eco Modular will execute a comprehensive mergers and acquisitions (M&A) strategy in the UK targeting enterprises possessing a strategic customer base in modular Accessory Dwelling Units and Temporary Accommodation for potential acquisition Eco Modular is actively engaged in advanced negotiations for tenders with accredited housing entities and prominent corporate entities that appreciate the inherent advantages from off-site volumetric modular construction Long TermEco Modular's long-term strategy centers on the full construction and operation of its state-of-the-art manufacturing facility in Eastern Europe equipped with an AI-integrated super system is designed to produce 160,000 sqm of volumetric modular systems globally by the end of 2025 The company plans to leverage existing contracts and forge new partnerships to reach full manufacturing capacity Eco Modular aims to establish itself as a key player in the global modular construction market executing contracts ranging from residential developments Advantages of Sustainable Modular Construction: Cost-Efficiency and Savings: Modular construction anticipates capturing $130 billion in the US and European construction market by 2030 with the potential for annual savings of up to $22 billion compared to traditional methods Reduced Timelines and Costs: Sustainable modular construction can reduce end-to-end project timelines by 20% to 50% and cut construction costs by up to 20% offering an economically and environmentally sound alternative Labor Efficiency: Up to 80% of traditional labor activity can be shifted offsite to manufacturing facilities in modular builds addressing the challenge of scarce construction labor and contributing to the reduction of labor-driven environmental impacts Population Growth and Housing Demands: With the global population projected to reach 8.5 billion by 2030 modular construction addresses the escalating demand for housing making it a sustainable response to unmet housing needs Sustainability in Materials: Modular buildings lead the market in utilizing eco-friendly materials incorporating recycled elements to minimize waste and promote sustainable construction practices Complementary Acquisitions for Sustainable Growth: The robust demand for sustainable modular construction creates a significant opportunity for Eco Modular to expand its production capacity and service offerings across new markets and geographies Technological Leadership and AI Integration: With an industry-leading technology team and scalable AI systems Eco Modular positions itself not just as an industry player but as a sustainability advocate integrating advanced technologies to enhance efficiency while minimizing environmental impact.Nurturing a Greener Future: Pursuing complementary acquisitions isn't just about expanding market reach; it's about fostering a greener future By consolidating efforts in this nascent and fast-growing environment Eco Modular aims to play a pivotal role in the industry's sustainable transformation Environmental Stewardship Through Eco-Friendly Practices: Eco Modular's commitment to sustainability extends beyond construction methods By employing eco-friendly building materials and championing the use of recycled materials the company actively contributes to reducing its ecological footprint and promoting responsible resource use Empowering Communities Through Sustainable Practices: Eco Modular's sustainable practices go hand in hand with social responsibility the company not only meets the demands of the present but also ensures a sustainable legacy for future generations Eco Modular stands at the forefront of a paradigm shift in construction leveraging sustainable modular practices to meet the demands of a growing population while actively contributing to a more environmentally conscious and socially responsible industry Co Founder and Chief Executive Officer of Eco Modular said:"I'm filled with immense passion for the modular manufacturing industry and the transformative impact we've had since our inception We've been on a mission to simplify processes and bring cutting-edge technology to the manufacturing landscape The integration with Zalatoris II is not just a milestone; it's a testament to our unwavering dedication I believe the potential of the modular market over the next 10-20 years has never been stronger and the lasting mark we'll make in this dynamic industry." Co Founder & Director EMEA of Eco Modular said: "As we embark on this new chapter as a public company I want to emphasise the strength of our corporate structure and management team at Eco Modular Our solid foundation and strategic leadership position us for continued success in the modular manufacturing industry This collaboration with Zalatoris II not only enhances our financial standing but also reinforces our commitment to delivering exceptional value to our stakeholders We are well-equipped to navigate the opportunities and challenges that come with being a public company and we are confident in our ability to drive sustained growth." I am thrilled about the opportunities that lie ahead with our integration with Zalatoris II We will strategically focus on initiating new projects in Europe and the Middle East leveraging the strengths of both Eco Modular to deliver innovative solutions to our clients in these regions The synergy between our teams positions us for success in undertaking transformative projects that will shape the future of modular manufacturing." Chief Executive Officer of Zalatoris II Acquisition Corp said:"The collaboration with Eco Modular is an exciting opportunity for Zalatoris II as we venture into the modular manufacturing space Eco Modular's commitment to innovation aligns seamlessly with our mission at Zalatoris II we will not only create value for our stakeholders but also contribute to the evolution of the manufacturing industry I look forward to a successful partnership with the entire Eco Modular team." Transaction OverviewThe business combination values Eco Modular at a $600 million enterprise value and at a pro forma market capitalization of approximately $666 million assuming a $10.00 per share price and no redemptions by Zalatoris II stockholders The transaction is expected to provide a minimum of $66 million in net proceeds to the company after transaction expenses The Boards of Directors of both Eco Modular and Zalatoris II have unanimously approved the transaction subject to customary closing conditions and stockholder approval AdvisorsArthur Cox LLP and Calabrese Consulting LLC are serving as legal counsel and as financial advisor to Eco Modular Nelson Mullins Riley & Scarborough LLP and Meteora Capital LLC are serving as legal counsel and as M&A Advisor to Zalatoris II Acquisition Corp About Zalatoris II Acquisition Corp.Zalatoris II Acquisition Corp which was formed to acquire one or more businesses and assets is a private and diverse US financial organization that is founded on tradition holds the distinction of being one of the oldest firms on the New York Stock Exchange (“NYSE”) it has consistently provided exceptional service to its family of listed companies Streicher’s Broker Dealer primarily focuses on NYSE activities its international investment team specializes in identifying guiding them through the complex process of transitioning into publicly traded entities The ultimate goal is to position these companies for a successful listing Streicher’s core strength lies in its ability to recognize strategic private target companies and assist them in becoming publicly traded entities on prestigious exchanges such as the NYSE or NASDAQ Additional Information and Where to Find It or by directing a request to Zalatoris II Acquisition Corp. Information about the Company’s directors and executive officers and their ownership of the Company’s common stock is set forth in the Company’s Annual Report on Form 10-K filed with the SEC on March 31 as modified or supplemented by any of the Company’s public reports filed with the SEC since the date of such filing including its Quarterly Reports on Form 10-Q and the other documents the Company has filed or will file with the SEC on Form 3 or Form 4 Other information regarding the interests of the participants in the proxy solicitation will be included in the proxy statement/prospectus pertaining to the Transaction when it becomes available These documents can be obtained free of charge from the source indicated above Eco Modular and its directors and executive officers may also be deemed to be participants in the solicitation of proxies from the shareholders of the Company in connection with the Transaction A list of the names of such directors and executive officers and information regarding their interests in the Transaction will be included in the proxy statement/prospectus for the Transaction This press release shall not constitute a solicitation of a proxy or authorization with respect to any securities or in respect of the Transaction This press release shall also not constitute an offer to sell or the solicitation of an offer to buy any securities nor shall there be any sale of securities in any states or jurisdictions in which such offer or sale would be unlawful prior to registration or qualification under the securities laws of any such jurisdiction No offering of securities shall be made except by means of a prospectus meeting the requirements of Section 10 of the Securities Act of 1933 This press release includes certain statements that are not historical facts but are forward-looking statements for purposes of the safe harbor provisions under the United States Private Securities Litigation Reform Act of 1995 Forward-looking statements generally are accompanied by words such as “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “expect,” “should,” “would,” “plan,” “predict,” “potential,” “seem,” “seek,” “future,” “outlook,” “project,” “anticipate,” “will likely result” and similar expressions that predict or indicate future events or trends or that are not statements of historical matters other than statements of present or historical fact included in this press release including those regarding the terms of the Company’s Business Combination Agreement with Eco Modular the Company’s ability to consummate the Transaction on the stated timeline Eco Modular’s use of proceeds from the Transaction and the combined company’s future performance relative to other manufacturing companies the growth of the modular construction sector and the combined company’s future products and services are forward-looking statements These statements are based on various assumptions whether or not identified in this press release and on the current expectations of the respective management of the Company and Eco Modular and are not predictions of actual performance These forward-looking statements are provided for illustrative purposes only and are not intended to serve as a prediction or a definitive statement of fact or probability Actual events and circumstances are difficult or impossible to predict and will differ from assumptions Many actual events and circumstances are beyond the control of the Company or Eco Modular Potential risks and uncertainties that could cause the actual results to differ materially from those expressed or implied by forward-looking statements include political and legal conditions; the inability of the parties to successfully or timely consummate the Transaction including the risk that any regulatory approvals are not obtained and behavior; disruption and volatility in the global currency and credit markets; the ability to maintain the listing of the Company’s securities on the NASDAQ; Eco Modular’s ability to implement its business strategy; changes in governmental regulation Eco Modular’s exposure to litigation claims and other loss contingencies; disruptions and other impacts to Eco Modular's business and government actions and restrictive measures implemented in response; stability of Eco Modular's suppliers as well as consumer demand for its products and services in light of disease epidemics and health-related concerns; the impact that global climate change trends may have on Eco Modular and its suppliers and customers; Eco Modular’s ability to recruit and retain qualified personnel to deliver their services; any breaches of Eco Modular’s information systems; fluctuations in foreign currency; changes in tax laws and liabilities The foregoing list of potential risks and uncertainties is not exhaustive More information on potential factors that could affect the Company’s or Eco Modular’s financial results is included from time to time in the Company’s public reports filed with the SEC and Current Reports on Form 8-K as well as the other documents the Company has filed including a registration statement on Form F-4 that will include proxy statements/prospectus that the Company intends to file with the SEC in connection with the Company’s solicitation of proxies for the meeting of shareholders to be held to approve If any of these risks materialize or the Company’s or Eco Modular’s assumptions prove incorrect actual results could differ materially from the results implied by these forward-looking statements There may be additional risks that neither the Company nor Eco Modular presently know or that the Company and Eco Modular currently believe are immaterial that could also cause actual results to differ from those contained in the forward-looking statements forward-looking statements reflect the Company’s and Eco Modular’s expectations plans or forecasts of future events and views as of the date of this press release Neither the Company nor Eco Modular gives assurance that either the Company or Eco Modular The Company and Eco Modular anticipate that subsequent events and developments will cause their assessments to change while the Company and Eco Modular may elect to update these forward-looking statements at some point in the future the Company and Eco Modular specifically disclaim any obligation to do so These forward-looking statements should not be relied upon as representing the Company’s or Eco Modular’s assessments as of any date subsequent to the date of this press release undue reliance should not be placed upon the forward-looking statements Email: pr@zalatorisac.com Emod is a game that allows players to construct different domes using various geometric patterns thought up by Leonardo Da Vinci around 500 years ago In contrast to the products available on the market up to now the development by researchers at the URV’s School of Architecture is easier to handle and can be used anywhere The game contains 70 pieces of wood which can support each other without the need for any binding agent and which can be used to create a wide variety of domes and bridges up to a metre square that are freestanding thanks to their own weight These structures are known in architecture as a reciprocal frames and they first appeared in the Codex Atlanticus twelve treatises by Leonardo Da Vinci on mathematics The name Emod is taken from the word dome spelled backwards and the game allows one or more people to make constructions that occupy an area of 1 m2 although children will only be able to do so autonomously from about the age of 5 onwards some of the skills that this pedagogical tool develops make it suitable for elderly people the game does not just work on knowledge areas such as history schools and even centres for elderly people” stated the creators of the game they got the idea from participants in a workshop on constructing Da Vinci’s domes that was run by Samper at events such the Nit de la Recerca (Research Night) and schools and at talks given to older people about architecture people always asked us if they could buy the pieces of wood anywhere” They therefore decided to reduce the size of their existing pieces to make it accessible to anyone the size of the pieces means that the game can be played on a table or on the floor at home although bigger domes can be made using more than one box of Emod the pieces are produced by the School of Architecture using compacted which means that they are able to sell the game for less than 30 euros Emod can be bought from the URV shop and collected from the following points of the University: the CRAIs on the Catalunya and Sescelades campuses the International Center and the Office of the Rector in Tarragona; the Bellissens Campus in Reus; the Vila-seca campus and the Terres de l’Ebre campus in Tortosa Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Google Maps 977 29 79 75 Help us improve this site — ULMS Racing Series returns home this weekend as the series visits McKean County Family Raceway on Saturday The MCFR event will see the Zimmer Service Center ULMS Late Model Series compete for $2,500 to win along with the Plyler Entry Systems UEMS Emod Series running for $1,000 to win The weekend begins at McKean County Family Raceway as the ULMS Racing Series makes its first visit of the year to the track it has called home since 2006 Series owner and promoter Chris Zuver has been a part of the Smethport oval most of his life and was the general manager and former promoter and lease holder of the track up until this past winter The series has hosted dirt late model events there every year since 2006 Mike Maresca of Potsdam has retaken the series point lead from Centerville Maresca will be making his first ever visit to McKean while Blair has been one of the dominant super late model teams over the past few years at MCFR The duo will be joined by other Close Racing Supply Elite drivers Other notables expected on hand are hometown favorite former track champion and legend Al Brewer of Cranberry in the famous Cochran Pontiac #1c machine The Plyler Entry Systems UEMS Emods will make their debut of the 2018 season and very good field of open wheel Emods are expected on hand led by three time and defending series champion Joel Watson Joining Watson and his potent #92 machine will be Randy Hall in the Tim Engles #68 machine Troy Johnson and Al Brewer is expected to have both his ULMS Late Model and his UEMS Emod entries on hand The MCFR event will pay $2,500 to win while the Plyler Entry Systems United Emod Series will also be in action on Saturday at McKean for $1,000 to win MCFR utilizes the Red AMB Transponder for both ULMS and UEMS classes Entry Fee for ULMS will be $25 and $20 for UEMS entrants The UEMS tire rule is NO SOFTS on the rear for the UEMS Emod teams Reminder to the ULMS Late Model teams that the Hoosier 1300 or American Racer 44 tire rule will be in effect and joining the ULMS Late Models and UEMS Emods will be the the RUSH Crate Late Models Manufacturing Today India Home > Automotive & Transportation > BorgWarner deepens major transfer cases deal with North American OEM The transfer cases will equip OEM’s combustion and hybrid trucks BorgWarner is expanding its collaboration with a major North American OEM by securing extensions on two transfer case contracts for upcoming vehicle launches The company will supply two types of two-speed transfer cases: the Electro-Mechanical On-Demand (EMOD) and Electric Shift-on-the-Fly (ESOF) These transfer cases will be integrated into the OEM’s combustion and hybrid passenger truck platforms with production expected to start in 2027 for two platforms and in 2028 for the third BorgWarner’s Vice President and President and General Manager of Drivetrain and Morse Systems expressed pride in continuing to supply transfer cases to the OEM after over 40 years of partnership She emphasised that these extensions highlight the reliability and quality of BorgWarner’s products The EMOD transfer case is designed for high performance providing faster response and improved torque management for enhanced vehicle safety and stability the ESOF transfer case is tailored for heavy-duty trucks featuring a two-wheel drive mode and the capability to switch to four-wheel drive while in motion Both transfer cases will be manufactured at BorgWarner’s facility in Seneca utilising the company’s advanced driveline technology for optimal efficiency and durability Recap: John Alexander led green to checkered to pick up his second straight win Recap: Burton Graham led flag to flag for his first win of the season Recap of Summer Shootout #1: A 24-car field seven cautions and three different leaders Jeffery McCaleb led laps 6-10 but would be Steven Holcomb 11-20 for his first Emod win this season it would be Craig Pedrick green to checkered for his fifth feature win of the season Recap: Bubba Green also went flag to flag to pick up win number six of the season Recap: Steven Holcomb led green to checkered to take his third win of the season and his second win of the night as he pulled double duty after winning the Emod feature Modified Street “Summer Shoot-Out #1” results Recap: Russell Boothe led green to checkered to take the win in the first Shootout event June 21t: No auto racing as there will be a motorcross event June 28: All Classes Racing … Double Points … Mini Stock Summer Shootout #1 … no super late models In the firearm world modularity is the name of the game from interchangeable backstraps for handguns to caliber conversions for rifles Nowhere is firearm modularity more important than the military One “weapons system” has to adapt to a wide range of physical sizes It is in this arena that the M16 has excelled As the ability to swap out parts quickly and easily has endeared the AR-15 to the civilian world the flexibility of the M16 platform has led to its adoption around the world.VLTOR’s A5 stock conversion (shown bottom installed) gives a length of pull longer than a standard A2 stock (top).In the first decade of the 2000s Marine Corps was looking to hold on to its M16A4s but was feeling the need for a little more flexibility in the platform The rifle’s fixed stock had always been a little too long for smaller-statured troops The trend for wearing body armor brought this problem to everyone If you look at photos of soldiers and Marines firing the M16A4 when wearing body armor you’ll notice they usually have the toe of the stock planted on the extreme edge of their shoulder or upper arm with their body canted 45-degrees to their target to achieve a proper length-of-pull and eye relief in 2009 the Marine Corps put out a Request For Information concerning the possibility of a collapsible stock system for the M16A4 that wouldn’t compromise the rifle’s reliability.The components of VLTOR’s A5 stock conversion (left) compared to the standard A2 stock components (right) The VLTOR conversion uses an intermediate length receiver extension and buffer paired with a standard rifle action spring The VLTOR extension attaches to the lower receiver like a standard M4 extension with a receiver end plate and castle nut which introduced its A5 Conversion system (it was assumed that the A4 rifle modified with a collapsible stock would become the M16A5) Instead of using standard M4 carbine components VLTOR designed a completely new receiver extension and buffer is shorter than the part used on a fixed-stock rifle which is likewise longer than an M4 buffer but shorter than a rifle buffer is paired with a rifle-length action spring The extension is attached in the lower receiver in the manner of a standard M4 stock setup with a receiver end plate and castle nut The A5 buffers are available in five different weights The kit is compatible with both direct-impingement and gas-piston AR systems except those chambered in .308.The VLTOR A5 stock conversion (bottom) provides a longer length of pull when fully extended than a standard M4 stock setup (top) The VLTOR extension has seven positions of adjustment and has marks that are visible through a witness hole on the supplied EMOD stock VLTOR pairs the new extension and buffer with its Enhanced Modular (EMOD) stock features a generous cheekpiece on each side bilateral quick-detach sling swivel points three battery compartments (two are waterproof) and a rubber recoil pad.VLTOR’s A5 stock conversion uses an intermediate length receiver extension (bottom) that is longer than a standard M4 extension (top).The A5 EMOD has seven positions of adjustability the length of pull (LOP) is 15.25”—longer than an A2 stock for those who need it Moving in to Position 5 (the receiver extension is marked with the number visible through a witness hole on the EMOD stock) yield about the same LOP of a standard A2 stock Position 2 puts results in about the same length as an A1 fixed stock All the way collapsed gives a LOP of 12.38” or about the same length as the third position out on a four-position M4 stock The fully collapsed A5 stock setup takes the overall length of a rifle with a 20” barrel down to 37.25” or about 2.25” shorter than a fixed A2 stock rifle.VLTOR’s A5 stock conversion is supplied with the company’s Enhanced Modified Among the stock’s features are a battery compartment another problem the VLTOR A5 system fixes is eye relief when using optics When placing an ACOG far enough forward on a flat top receiver to put a backup sight behind it it’s often hard to get the proper eye relief with a fixed A2 stock Bringing the VLTOR in a few clicks on our FN 15 test rifle fitted with the 4x32 ACOG and the MaTech backup iron sight fixed this.VLTOR’s A5 stock conversion is supplied with the company’s Enhanced Modified which features two waterproof compartments for storing the CR123 batteries used in many electronic sights All of the components for the A5 kit weigh just 3.4 ozs The complete kit with stock retails for $215.In Marine Corps testing VLTOR’s A5 stock provided as reliable as a fixed stock M16A4 While some VLTOR A5-equipped M16s were used in the field The Marines decided to go with the M4 carbine to replace their M16 The VLTOR A5 stock kit fixes the same problem in the civilian world that it did in the military It gives the owner of a 20” barreled rifle an adjustable length of pull without sacrificing reliability It is also an upgrade for shorter barreled M4-style carbines where VLTOR claims it will slow down the cyclic rate and improve reliability And for those who have to have a clone of every rifle in the U.S they can use the VLTOR kit to build the A5 Long respected for its world-leading military small arms through its American factory and engineers shooters—and the new Concealed Carry 9 mm Luger micro pistol is poised to quicken it Read today's "The Armed Citizen" entry for real stories of law-abiding citizens Despite a slight decline in demand for new firearms the industry’s economic impact rose from $90.5 billion in 2023 to $91.7 billion in 2024 Kahr Arms has been most well-known for its single-stack line of concealed-carry pistols the company is moving into the double-stack market with its new Premium X Series Henry's Special Products Division has officially released its first line of unique offerings in its HUSH series of suppressor-ready lever-action rifles Built primarily from thick 6061 aircraft-grade aluminum is an incredibly robust and stable gun rest designed for use with pistols and long guns alike Home > Sectors > Detroit Engineered Products (DEP) presents its electrification module DEP would be exhibiting engineering and consulting services Detroit Engineered Product would be a part of the Auto Expo DEP is showcasing its innovative eMOD (Electrification Module) electric vehicle design and development services for two-wheelers DEP is also exhibiting its extensive range of advanced engineering and consulting services including reduced order model (ROM) and expertise in computer aided engineering (CAE) parametrization as well as the most recent advancements in the field of advanced driver assistance systems (ADAS) On display is the most recent version of their integrated CAE platform MeshWorks which is outfitted with capabilities for reducing CAE modelling time by 30% with process automation and optimization features Vice President of Detroit Engineered Products “We are happy to be part of this incredible exhibition as we plan to meet potential customers at the buyer seller forum to discuss futuristic automotive product development services Events like these give us the opportunity to interact with people and understand the tones of the varied technologies available in the market We look forward to meeting more like-minded individuals from the auto sector to push for conversations around research and development in auto design software.” “There will be an exclusive demonstration of the most recent version of our integrated CAE platform which includes a focused toolset for EV development We can confidently promise faster turnaround times and optimised solutions during the design and development stage because of our efficient processes and highly skilled team,” added Basant Electric vehicles and Heavy and light-commercial vehicle initiatives face multiple design challenges because of their increasing dependency on electrical components and overall complexity DEP’s product development team is equipped with the capabilities to address these issues and by using frugal engineering principles it can ensure that innovative and exciting technology can be made available to users at affordable prices Home > Products > DEP MeshWorks 2023 takes engineering simulation to new heights Transforming product development with advanced features and next-generation CAE technology has announced the release of DEP MeshWorks 2023 the most robust and advanced version of MeshWorks.  this integrated CAE platform revolutionises engineering simulation in design and analysis Its powerful backend incorporates advanced algorithms while the user-friendly front-end interface ensures ease of use and CAE Parameterization expedite product development cycles MeshWorks 2023 is particularly beneficial for automotive The comprehensive toolkit enables rapid design while new modules like Reduced Order Modeling and electrification (eMoD) drive innovation.  expressed enthusiasm about the launch of DEP MeshWorks 2023 considering it the most advanced version of MeshWorks to date He conveyed confidence that the new features and improvements would revolutionise the product development cycles of their customers Here at Gizmag we are always keeping an eye on innovative solutions for schooling and education. We've covered the solar powered mobile computer classroom project and the AIRchitecture flying classrooms of the future but now we're excited about these proposals from architects all over the world who recently submitted their ideas for what schools of the future could look like The winners for the "Future Proofing Schools" design competition were recently announced where designers where invited to submit their ideas for the next generation of relocatable classrooms the Melbourne School of Design (MSD) and the Australian Institute of Architects creativity and blue-sky thinking" and may just give us a peek into the future The competition focuses on new ideas for relocatable classrooms which in recent decades have commonly been used around the globe These types of classroom facilities are generally a response to rapid growth in schools remote community needs or a quick solution to cope with natural disasters Although the classrooms are often described as cheap and miserable the winners for this year's competition are anything but drab and dreary The winning design idea from architecture firm Architectus took home AU$25,000 (US$26,831) for its futuristic vision of the classroom Dubbed eMOD (Educational Modular Offsite Design) the concept is a flexible modular design system that can be configured to create a building solution that adapts to specific requirements such as site The winning entry included a clever proposition of an app to formulate the modular design which proved to be a hit amongst the judges "The concept represents the essence of an idea about the link between 21st century learning and space" said the jury "[It] is both sophisticated and simple .. and is suggestive of adaptable and transportable space." The eMOD design encompasses a learning space in all elements of the building that goes beyond the limitations of the walls Learning areas include the internal/external environments around the building and the internal spaces that also provide adaptability to accommodate group-based student work or individual time You can try out the eMOD app for yourself online architecture firm NBRS+PARTNERS impressed the judges with its futuristic MODUPOD concept "It was the suggestive flexibility of the organic core to the building and its capacity to indicate closed unwrapped or linear active space that proposed an aspiration for a learning community over and above a rational workable arrangement of classrooms," said the jury MODUPOD is a vision for 2025 and represents a dynamic 21st century learning environment with 3D text books promoting interaction and critical thinking for students. The concept features fast assembly smart interiors and flexible PODS that place students and teachers at the heart of the learning experience. Dynamic multi-modal clusters are built around the central permeable student resource center The active core can also function as a media platform featuring multimedia screens that encourage the presentation of school news Individual modules include the teamwork focused Studio; the Project Pod which encourages students to take greater responsibility for their own learning; a transparent Breakout Pod to observe and be resourceful; and the Social Pod to gather collaborate and securely showcase interactive learning the Outdoor Spaces offer students the opportunity to learn from nature All aspects of the MODUPOD concept meet the a spectrum of curriculum needs The third place entry by Oliver Ebben from Studioquint in Amsterdam was praised for its architectural deliberation "The rational classroom form is made both spatial and place specific by three dimensional origami-like scales that articulate the form both internally and externally," said the jury while internally they become three dimensional The rooftop contains a locally contextual landscape This entry also included some great sustainability functions such as using components that are fabricated from recycled polystyrene To avoid dissipation of energy during the transportation phase the thermal building mass is added on site by making use of local soil and plants the building components can function as reservoirs for rainwater and the three-dimensional design of all building components at an angle of 20 degrees enables efficient use of photovoltaic panels and a high rate of sun shielding Although LAVA architects didn't take home an award we thought its submission was worth mentioning LAVA's relocatable school is a learning space for the future with a sustainable design that incorporates prefabrication and small lightweight easily transportable modular elements The modular facade system is manually operable and features a flexible system to create more light or shade The "three axis" geometry design allows for interlocking of various configurations to adapt to changing class sizes learning clusters and future learning methods "We wanted to turn this idea upside down and create spaces that are sustainable cost-effective whilst fun and exciting to be in," said Chris Bosse The concept received a commendation in the Australian Future Proofing School competition Source: Future Proofing Schools, LAVA Eberlestock has some new and re-designed gear for those who will be tracking elk or going downrange Eberlestock is a company known for its load-carrying backpacks in both hunting and military circles but has been expanding their offerings to clothing and other products in the past few years I think its great to see such a large company taking feedback and improving their gear with redesigns let’s dig into what’s new and what’s been tweaked Eberlestock/Clothing Coverage on AllOutdoor  “The Team Elk Pack is unlike any other backpack on the market It has unique features like the patented rifle-back scabbard a comfortable aluminum frame meant to carry heavy loads and a meat carrying system that allows the pack to be separated from the frame for packing out game from the backcountry and stretch-material pockets throughout the exterior of the pack On the interior of the pack you will find stretch pockets and a hydration sleeve and hook.” With so many changes coming to this fan favorite pack Eberlestock has a video dedicated to explaining the differences “The Vapor 2500™ is the smaller of our ultra-lightweight series of EMOD™ packs with a capacity of 2800 cubic inches Designed specifically around the F1 Mainframe™ (F1 Mainframe not included) the Vapor Series is our most versatile and lightweight pack system The V25 has all of the same great features as our larger 5000 pack but in more compact The external features of this pack include extended-depth stretch pockets designed to securely hold items like drink bottles the center front panel is made from the same 140D two-way stretch material and features a zippered pocket for quick access to essential items you can choose between camouflage options constructed with 450D Aramid reinforced ripstop material or solid colorways made from 500D Nylon ripstop fabric One notable feature is the removable Duraflex HD 25mm buckles which enable you to expand the pack away from the frame This creates a channel that allows you to carry meat bags or heavy loads close to your body and at the center of gravity for improved balance and comfort as well as incorporate a tactical weapon-sized scabbard the X31 LoDrag II™ has been a staple in the precision rifle world the LoDrag II features a fold-away shelf to segregate the top and bottom load space and a hydration sleeve for our WX2L and WXP3L hydration systems Side compression straps now feature HD 25mm buckles for the quick release of items like tripods compressed to the side of the pack.” the EMOD lid allows the user to add capacity to their pack when they need it and can easily remove it when not needed “The EMOD Lid attaches to the Vapor (both 2500 and 5000c.i old and new versions) and Mainframe system in 4 locations using quick-detach gatekeeper buckles The EMOD Lid allows you to add additional capacity to the Vapor for smaller items and utilize the EMOD Lid to compress items between it and the top of the Vapor pack The EMOD Lid features a top pocket made of durable stretch fabric and a main compartment large enough to store accessories and small gear items.” “The EMOD Game Bag is designed to protect meat from any element and durable fabrics that trap odor and won’t fail The EMOD Boned Out Game Bags are designed to protect meat from any element and durable fabrics that trap odor and won’t fail.” These are both products that just make a lot of sense and I’m surprised to see that Eberlestock is just bringing them to market now This definitely seams like a good product to have when packing out large amounts of meat in the backcountry or just for travel Say hello to a lightweight packing cube solution for holding your clothing or other miscellaneous gear these pouches will help you organize your smaller and larger items “The Grid Pouch is lightweight and durable designed to fit securely within our configurable panels found in the Bang-Bang The Grid Pouch also functions well as an organizational pouch to be placed in any pack for convenient and secure storage of small items nylon ripstop allows for a quick review of the contents at a moment’s glance and it comes in 3 sizes for any kit or configuration.” For more information and pricing be sure to check out Eberlestock’s website Here Patrik is a freelance photographer who has been lucky enough to see a lot of the world and document his travels with his camera government as a Public Affairs Officer documenting Multi-National Special Forces Training around the World He is currently working on becoming a Blackhawk Pilot for the Army while being an avid gear junky and 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