Lenti primarily focuses on the Tiger offense His fifth and final season on staff saw Lenti helped the Tigers to a 29-21-1 overall record while playing the 11th toughest schedule in the nation The 2024 season featured Auburn’s most wins over Quad 1 teams since the 2018 season with nine The Tigers earned their first series win in Baton Rouge since 2015 after taking two wins at No Auburn also clinched back-to-back series wins over in-state rival Alabama for the first time since the 2017 and 2018 seasons Auburn also earned its 10th consecutive NCAA Regional appearance traveling to Tallahassee The Tigers advanced to Sunday’s championship round for the second straight season In her best season of her collegiate career KK McCrary help lead the Tiger offense alongside Anna Wohlers as the duo both ended the season with averages above .300 on-base percentage (.454) and slugging percentage (.571) in her second season on The Plains During his fourth season as an assistant coach Lenti saw Auburn post a 43-19 overall record The Tigers also posted a 15-9 record in SEC play to finish third in the league their first winning record and highest league finish since 2017 Auburn also earned its first series win over LSU and its first series win at Alabama since 2017 during its historic run Auburn earned its ninth consecutive NCAA Regional appearance and forced the “if necessary” game at No Auburn ranked in the top five in the SC in runs scored (323) and home runs (64) Nelia Peralta was the heart of Auburn’s offense during the 2023 as she led the Tigers in hits (54) batting average (.329) and on-base percentage (.479) Peralta was the first Tiger to record 50 or more hits in a season since 2019 and her efforts were rewarded with an All-SEC Second Team and NFCA All-Southeast Region Third Team honors Denver Bryant joined Peralta as an All-SEC Second Team member after tuning in a .322 batting average in SEC play At the plate a total of four Tigers closed the 2023 season with a batting average of .300 or higher Lenti’s third year with the program featured a massive overhaul to the program’s offense More than tripling its home run numbers from a season ago Auburn finished 14th in the nation with 86 The mark was the third highest total in a season in school history Auburn’s offense was also highlighted with top-five season performances in team batting average After opening the season with a 24-1 record the Tigers would end 2022 with a total of 40 victories The Tigers earned a postseason berth as the two-seeded team at the Clemson Regional its eighth consecutive NCAA Tournament appearance Auburn’s revitalized offense was due in part to the 2022 freshman class Auburn’s top three RBI producers of the 2022 season were freshmen Bri Ellis Ellis was the breakout star as she shattered the program’s freshman home run record with 20 A top-10 finalist for Schutt Sports/NFCA National Freshman of the Year Ellis was also tabbed to Extra Inning Softball’s All-Freshman Team and added Second Team All-SEC honors after leading the Tigers in home runs At the plate a total of nine Tigers closed the 2022 season with a batting average of .300 or higher including everyday starters Carlee McCondichie Lenti helped lead the Tigers to their seventh straight NCAA Regional appearances as Auburn boasted the seventh-toughest schedule in the country highlighted by the program’s first victories in Columbia 12 Kentucky picking up the series win at Jane B Breaking out as one of the two most consistent players at the plate during conference play Makayla Packer and Sydney Cox were two of a program-record four Tigers honored as members of the 2021 SEC All-Freshman Team Packer closed the season with a team-leading .303 average Lenti’s first season on The Plains was shortened due to the COVID-19 pandemic but he guided the Tigers to a 16-11 overall record that featured wins over No three Tigers finished the 2020 season with a batting average over .340 Head coach Mickey Dean announced Lenti’s hiring on June 14 Lenti was DePaul University’s all-time winningest head coach spending 37 years at the school from 1980-87 and 1990-2018.During his time at the helm of the Blue Demons while being named part of the BIG EAST Coaching Staff of the Year six times Mid-Continent Conference (The Summit League) Coach of the Year three times and North Star Conference Coach of the Year once He was also named C-USA Women’s Coach of the Decade in 2005 and C-USA Softball Coach of the Decade Lenti was named the NFCA National Coach of the Year in 1999 after leading DePaul to a school-record 54 wins reaching the Women’s College World Series semifinals and finishing third in the NFCA/USA Today final top 25 poll Lenti and his staff led the Blue Demons back to the WCWS after not allowing a run during regional contests against Michigan Lenti was inducted into the NFCA Coaches Hall of Fame in 2008 Lenti led DePaul to 20 NCAA Tournament appearances nine conference Player of the Year and 10 conference Pitcher of the Year accolades Lenti was an English teacher and Chairman of the English Department at St Ali and Gena played softball at DePaul while all three graduated from the university Developed in collaboration with Paola Lenti the lightweight ‘Alma’ collection combines CNC-shaped steel frames with an elastic mesh support traditional moulds are replaced by generatively designed components enabling flexible assembly and endless variation the ‘Alma’ armchair pairs structural clarity with subtle tactility Optional cushions add softness and colour customisation Argentine designer Francisco Gomez Paz and Italian brand Paola Lenti unveil ‘Alma’ – a lightweight technically advanced outdoor seating system 'When you have an unconventional design idea you need to work with a company that has courage,' says Argentine designer Francisco Gomez Paz his concept – a new family of outdoor seating designed using generative algorithms and numerical control technology – found a courageous collaborator in progressive Italian brand Paola Lenti the series harnesses generative algorithms and CNC technology to shape elegant stainless-steel frames finished with an elastic mesh that offers support and comfort without the need for padding costly mould would define the form of a seat; here technology replaces that limitation with a flexible system of components Each element is precisely generated and can be combined in multiple ways allowing for exceptional variety and virtually limitless customisation ‘Francisco’s vision seamlessly integrates innovation and environmental responsibility – values that have always guided our brand,’ she explains ‘Alma’ is a study in subtraction ‘Alma consists of a structure with an attached elastic net that alone provides the right support and seating comfort,’ Lenti says The CNC-formed frame is made of matt or gloss-varnished stainless steel and can be used alone or layered with optional cushions for added softness colour is thoughtfully deployed: the collection launches in ivory and graphite but cushions can be specified in the full spectrum of the brand’s fabric palette Material innovation also plays a central role The cushions and pads are filled with a biodegradable recycled polyester fibre – a polyurethane-free alternative that delivers comfort without compromise 'We live in an era that demands sustainable practices,' says Gomez Paz we tackled the challenge of polyurethane use in seating identifying alternative solutions that are both light and comfortable.' Beyond its aesthetics and engineering, ‘Alma’ reflects a broader ethos that sets Paola Lenti apart. Headquartered and manufacturing in Meda – a town 11 miles north of Milan long regarded as the centre of Italian furniture production – the female-founded and led brand operates with a quiet confidence that feels almost radical in an industry still largely shaped by male voices and top-down hierarchies Paola Lenti established the company alongside her sister Anna who began her career as a nuclear engineer working in the aerospace industry Their backgrounds couldn’t be more different – one rooted in material experimentation and colour and precision – yet together they’ve built a brand defined by both creativity and clarity while Anna – often travelling with her laptop and Excel files – handles the strategic and commercial side of the business It's a complementary partnership built on constant exchange and mutual trust escapism and design stories from around the world direct to your inbox 'My sister and I have always followed our instincts,' says Lenti 'We’ve grown into an industrial reality while preserving a human dimension.' That human scale is evident in the way the company works – collaborating closely with tailors and supporting a fully Italian supply chain rooted in long-standing relationships and shared creative potential That spirit of shared authorship runs through ‘Alma’, too. As Lenti puts it: 'This is not just a collection of seats, but a micro-architecture that embodies the values of our company.'paolalenti.it writer and creative consultant specialising in design places and people for titles such as Dezeen which also added the abandoned program CAL-H an ex vivo hematopoietic stem cell (HSC) gene therapy “We have conducted a strategic evaluation of our R&D footprint to support this change and have identified opportunities to capitalize on a strategic and technical convergence with our sa-mRNA [self-amplifying messenger RNA] capabilities and leverage synergies across the technologies/platforms,” the firm confirmed to BioProcess Insider CSL will move our cell and gene therapy (CGT) research and development activities to Waltham Massachusetts and close our Pasadena-based operations.” and while some positions will relocate to Waltham CSL Behring entered the sa-mRNA space through a $200 million collaboration and license agreement with Arcturus Therapeutics in 2022 The company gained access to Arcturus’s sa-mRNA vaccine and lipid nanoparticle (LNP) platform technologies tackle delivery problems typically associated with viral vectors and existing lipid vector technology by capturing therapeutic nucleic acids and safely moving them to target cells using an endocytosis process Hemgenix is an in vivo adeno-associated viral-based (AAV-based) gene therapy CSL will still focus on gene therapies as part of its wider strategy “We are excited about Hemgenix as an important treatment option for appropriate patients living with hemophilia B and are proud to have delivered the first gene therapy for patients living with this serious condition,” the spokesperson told us “Our dedication and focus on Hemgenix is steadfast and our decision to move our genetic medicines capabilities to Waltham has no impact on Hemgenix.” Hemgenix is manufactured at a Lexington, Massachusetts site formally owned by uniQure. Contract development and manufacturing organization (CDMO) Genezen acquired the site earlier this year for $25 million Hemgenix – which has a list price of $3.5 million – contributed to a 10% revenue increase within a hemophilia portfolio that totaled $1.3 billion The firm also noted some success in inking reimbursement approvals in the US Journalist covering the international biopharmaceutical manufacturing and processing industries.Founder and editor of Bioprocess Insider a daily news offshoot of publication Bioprocess International with expertise in the pharmaceutical and healthcare sectors regulatory affairs and business development.From London UK originally but currently based in Montpellier France through a round-a-bout adventure that has seen me live and work in Leeds (UK) Matica Bio partners with Texas A&M to support CGT development CSL Seqirus signs pandemic preparedness plan with European Commission Ins & Outs: Biopharma players shuffle c-suite ranks American made: Companies continue to emphasize US manufacturing Registered in England & Wales with number 01835199 where the master ceramicist lives and works potters had no means to procure clay on a large scale and turned to the mountains and rivers that surrounded them Morales gathers soils and mineral samples from the very same environment which he then translates into different compositions and textures in clay this collection celebrates the alchemy achieved using expert craftsmanship with found materials The Stelo is made up of independent majolica elements stacked on top of each other to form organic and are installed with rubber spacers in between to protect the pieces from damage This also allows for a smoother fitting process These elements can be arranged in any manner The Primula is composed of extruded majolica elements Reminiscent of limpets and other primeval sea creatures these components offer different views from the top and the side deeply inspired by the aquatic world he is so close with Much of his work is inspired by the sea or aquatic forms allowing the artist to play with the intricacies of clay composition and color with each nuanced take The top of the table is finished with the slightest of opacities and is rounded smooth on all edges reminding us of sea glass found tumbling naturally onto rocky shores Helico is our next piece in the collection the thick glass tabletop hand-finished to create beautiful texture on the underside of the table This slightly opaque top reveals the forms of the extruded legs ceramic pieces reminiscent of prehistoric trilobites and shells that dot the ocean floor The irregularity of the organic shapes within the confines of the clay composition makes for a beautiful originality in the finished pieces The legs are glued to the top for security and the feet are capped with rubber to prevent damage Anemone is a side table like no other hand sculpted using custom blends of clay from the hillsides of Caltagirone Layer upon layer of glaze creates ribbons of color running horizontally along organic shapes relying on the consistency of the glaze to pull the color organically down the surface of the table all of the glaze combinations are numbered with a color code describing the tone that’s inside working with collaborators to tune the finishes and combinations of clay and chemicals to client’s exact specifications and the artist keeps the experiments in composition to further inform future iterations To follow Morales’ work on Instagram, click here. For more from Paola Lenti, click here Growing up in NYC has given Aria a unique perspective into art + design constantly striving for new projects to get immersed in handwork and personal touch is central to what she loves about the built environment You can follow Aria Lee on Pinterest, and Instagram. Read all of Aria Lee's posts FiiO'S sub-brand Snowsky has launched the Retro Nano user-friendly vinyl flattening machine that restores warped records to their original shape using precision heat technology Full of natural materials and respect for modern Swedish design the STOCKHOLM 2025 collection from IKEA debuts 96 new pieces Zaha Hadid Architects transforms public transit at the KAFD Metro Station in Riyadh with futuristic architecture You’ll always hear it from Design Milk first Our passion is discovering and highlighting emerging talent and we’re energized by and for our community of like-minded design lovers — like you Jeanne Lenti Ponsetto Earns Women Leaders in College Sports Lifetime Achievement Award8/16/2023 10:50:00 AM | ATHLETICS 14 of the 15 Blue Demon programs represented the school in 57 NCAA team championships as either conference champions or at-large selections along with 154 NCAA individual championships appearances – including 17 straight NCAA appearances by the women's basketball program and two trips to the Women's College World Series for the softball program student-athlete academic success and career planning ranked chief among them the Blue Demons garnered 80 NCAA APR Awards and led the Big East in team Academic Excellence Awards and Scholar Athletes of the Year Jean also served the intercollegiate athletics community with a combined 62 years of service including multiple years simultaneously on more than one NCAA Committee and/or affiliate organization highlighted by leadership roles including Vice Chair of the NCAA Council and notably as Chairperson of the NCAA Championships Cabinet the NCAA Division 1 Women's Basketball Committee the NCAA Women's Basketball Oversight Committee and Collegiate Women's Sports Award she also served on numerous NCAA committees she served on the NACDA Board of Directors as 1st Vice President and was President Elect (2021) Jean is a past President (2006) and board member of Women Leaders in College Sports Jean has earned several awards for her outstanding work at DePaul and for leadership serving the NCAA members and student-athletes including two NACDA Under Armour Athletic Director of the Year Awards (2009 Women Leaders in College Sports Administrator of the Year Award (1998 WBCA Administrator of the Year Award (1998 2017) and the WBCA President's Award (2017) for her innumerable contributions to the sport on a national level Jean is a member of the DePaul Athletic Hall of Fame the Chicagoland Sports Hall of Fame and the National Italian American Hall of Fame and the National Association of Directors of Athletics Hall of Fame Her work within the Chicago sports scene has been duly noted Jean was named one of the top 100 most influential women in Chicago by the Chicago Sun-Times In 2023 Jean was awarded NACDA IAAA ADA Gary Cunningham Lifetime Achievement Award and the Collegiate Women Sports Award's Dr Judie Holland Legacy Award for her tenure in preserving the oldest awards program for the nations most outstanding collegiate women athletes There is little argument that societies around the world are navigating many complicated economic The SDGs put a framework and metrics to many of these diverse problems But the complexity of underlying trends does not lend itself to tidy simplifications A more nuanced diagnosis of the dynamics is important to inform problem-solving over the SDG “second half” out to 2030 this paper offers an assessment of SDG-relevant empirical trends to date We identify four different standards to assess progress each of which yields different interpretations of the data The case of under-five child mortality illustrates the range of takeaways inspired by different tests The world achieved a 20% decline in the number of deaths of children under 5 over the first seven years of the SDG era from 6.1 million deaths in 2015 to 4.9 million in 2022 42 low- and middle-income countries saw a significant slowdown in their rate of progress compared to pre-2015 trends and only 20 saw a significant acceleration Fully 132 countries are on track to meet the SDG mortality target by 2030 and 60 countries are on a path to falling short the shortfalls add up to 10.5 million children’s lives lost for good So even though more than a million fewer children dying every year is a source of encouragement more than 10 million deaths due to shortfalls over the next several years is a grave concern Our empirical strategy focuses on country-level trends across 24 SDG-related indicators with time-series data available for at least 100 countries since 2015 Although we would prefer to include a wider array of indicators limited cross-country data availability impedes our ability to do so By applying the various lenses for assessing SDG progress our aim is to distill key patterns amid global complexity rather than to present precise point estimates All forward-looking estimates should be interpreted with appropriate caution amid the inherent uncertainty and limitations embedded in such calculations Despite the world’s deep and ongoing strains the human condition has improved on several fronts since 2015 But many positive trends were already in motion prior to 2015 and improvement alone does not meet the higher normative standards established in the SDGs Issue-specific progress assessments suggest issue-specific policy architectures still matter widespread gaps relative to the world’s agreed ambitions for 2030 suggest the need for more systematic changes in approaches across SDGs With only six years remaining to the deadline there is tremendous value in the existence of time-bound international goals to inform substantive assessments on the nature of global sustainable development progress during a turbulent political era A carefully nuanced approach to assessing absolute changes and potential tipping points—country by country and target by target—remains crucial to identifying better pathways toward achieving the world’s stated ambitions Download the full working paper Metrics details We recently developed an immuno-oncotherapy against human papillomavirus (HPV)-induced tumors based on a lentiviral vector encoding the Early E6 and E7 oncoproteins of HPV16 and HPV18 genotypes The robust and long-lasting anti-tumor efficacy of Lenti-HPV-07 is dependent on CD8+ T-cell induction and remodeling of the tumor microenvironment we first established that anti-vector immunity induced by Lenti-HPV-07 prime has no impact on the efficacy of a homologous boost to amplify anti-HPV T-cell immunity To longitudinally monitor the evolution of the T-cell repertoire generated after the prime homologous or heterologous boost with Lenti-HPV-07 we tracked T-cell clonotypes by deep sequencing of T-Cell Receptor (TCR) variable β and α chain mRNA applied to whole peripheral blood cells (PBL) and a T cell population specific of an immunodominant E7HPV16 epitope We observed a hyper-expansion of clonotypes post prime accompanied by increased frequencies of HPV-07-specific T cells there was a notable diversification of clonotypes post boost in whole PBL We then demonstrated that the effector functions of such Lenti-HPV-07-induced T cells synergize with anti-checkpoint inhibitory treatments by systemic administration of anti-TIM3 or anti-NKG2A monoclonal antibodies While Lenti-HPV-07 is about to enter a Phase I/IIa clinical trial these results will help better elucidate its mode of action in immunotherapy against established HPV-mediated malignancies The strong efficacy of Lenti-HPV-07 treatment in the preclinical model led us to set up the preparation of a phase I/IIa clinical trial by using Lenti-HPV-07 pseudotyped with VSV-G from Indiana (Lenti-HPV-07ind) or New Jersey (Lenti-HPV-07nj) serotype in prime-boost immunizations we asked whether: (1) a primary injection of Lenti-HPV-07ind can induce vector-specific adaptive immunity (2) such immunity could impact the efficacy of a homologous boost and (3) heterologous boost may have some advantage for T-cell induction we observed that this diversification does not influence clonotypes associated with the immunodominant epitope This suggests that the diversification primarily affects clonotypes recognizing sub-dominant epitopes Our results provided evidence of notable synergistic effect of both anti-TIM3 and anti-NKG2A mAbs on anti-HPV effector T cells induced by Lenti-HPV-07 immunotherapy a Timeline of single injection or prime-boost immunization with 1 × 109 TU of Lenti-HPV-07ind or Lenti-HPV-07nj c ED50 comparison of anti-VSV-Gind neutralizing antibodies in sera from mice primed with Lenti-HPV-07ind and boosted homologously with Lenti-HPV-07ind or heterologously with Lenti-HPV-07nj ED50 against VSV-Gind (b) or against VSV-Gnj (c) (n = 4/group) Statistical significance was determined using a repeated measures (RM) two-way ANOVA (*p < 0.05 IFN-γ ELISPOT responses of T splenocytes from the same individual mice were studied at the indicated time points after in vitro stimulation with (d) six peptide pools spanning the full sequence of VSV-Gind or (e) four peptide pools spanning the sequence of detoxified E6HPV16 f IFN-γresponses of T splenocytes of mice assessed at D14 after a mono-injection with 1 × 109 TU of Ctrl lentiind Lenti-HPV-07ind or Lenti-HPV-07ind heat-inactivated at 70 °C during 1 h (n = 6) Stimulation was performed using either the indicated lentiviral vectors or peptides both at 4 µg/ml Statistical significance was determined by Mann–Whitney t-test (ns not significant which can explain the reason why T-cell responses to these epitopes were not boosted with Lenti-HPV-07nj This result showed that residual proteins originated from transgene expression during the vector production and possibly still present in the vector samples do not induce detectable specific T-cell responses induction of specific T-cell responses by these vectors relies only on their in vivo transduction ability a homologous or heterologous boost with Lenti-HPV-07ind or Lenti-HPV-07nj increased the intensity of the specific anti-HPV T-cell effectors without any sizeable impact of the adaptive immunity against the vector backbone a Timeline of prime-boost immunizations with 1 × 109 TU of Lenti-HPV-07ind Lenti-HPV-07nj or Ctrl Lentiind and TCRβ sequencing performed on RNA extracted from peripheral blood cells b Estimation of the TCRβ repertoire diversity using “true diversity” index which allows to divide the clonotypes into Small (0 < X ≤ 10–4) Large (10–3 < X ≤ 10–2) and hyperexpanded (10–2 < X ≤ 100) categories Relative abundance is the sum of the frequencies of all clonotypes from a given category d Pie chart representing average proportions (mean) of Medium Large and hyperexpanded categories in each group e Follow up of the frequencies for the top 100 most abundant clonotypes f Classification of the top 100 most abundant clonotypes detected post boost according to their expanding or contracting evolution since prime New post boost clonotypes were defined from the comparison with top 100 post prime Expanding or retracting/stabilizing clonotypes were defined as those having increasing or decreasing frequencies post boost respectively g Frequencies of expanding or contracting clonotypes Statistical significance was determined using a one-way ANOVA in (b) and Error bars on the histograms represent standard deviation observed in both Ctrl Lentiind and Lenti-HPV-07ind groups may indicate a post boost retraction/stabilization of the initial clonotypes possibly specific to immunodominant epitopes subdominant epitope-specific clonotypes emerging post boost to diversify the T-cell repertoire b Chord diagrams representing the Jβ and Vβ association of in the top 100 most abundant clonotypes Chords are colored according to the Jβ-gene segment showing Jβ and Vβ segment usage in association to CDR3 amino acid sequence of each clonotype Ctrl Lenti (squares) and Lenti-HPV-07 (circles) groups post prime (blue) and post boost (green) timepoints and mouse numbers are indicated inside the symbols Cluster dendrograms indicate the unweighted hierarchical proximities between samples d Frequencies of the 15 clonotypes shared by all samples at each time point e Frequencies of clonotypes which exclusively emerged in the Lenti-HPV-07ind/nj-injected mice at each time point and their 3-to-6 sharing levels Numbers of clonotypes per category are indicated on the right Median of each violin box is indicated in red had neglectable variations post prime and post boost in both Ctrl Lentiind and Lenti-HPV-07ind/nj groups suggesting that vaccination has no general bystander effect on an irrelevant TCR repertoire explaining the high level of sharing observed here d percentage of all reads of the top 10 most abundant clonotypes for each mouse Each color corresponds to distinct clonotypes from the least abundant (top) to the most abundant (bottom) e Chord diagrams representing the Jβ and Vβ association of in the top 100 most abundant clonotypes f Network representing CDR3 sequence proximity between top 10 most abundant clonotypes of all post prime and post boost mice (n = 65 CDR3 sequences) An edge between CDR3 sequences was added according to their LD Groups represent a cluster of CDR3 sequence with an LD < 3 g Amino acids logo for each group of related CDR3 sequences These results globally highlight the initiation and evolution of clonotypes mobilized by Lenti-HPV-07 immunization which allows the expansion of subdominant clonotypes and favorizes the diversification of antigen-specific TCR repertoire monitoring the E7HPV16 specific T cells indicated that a boost immunization did not significantly alter the clonotype diversity within a T subset specific to an immunodominant epitope It must be mentioned that this strategy has inherent limitations due to the lack of antigen specificity when evaluating the efficacy of lentiviral vectors other immunogenic carriers or viral vectors that can trigger non-specific responses Having thoroughly characterized the clonotypes that take part in the T-cell response induced by Lenti-HPV-07 vaccination we then examined the anti-tumor function of these T cells and the possibility of disinhibiting their anti-tumor effector functions by ICI treatments When the tumor volume reached an average of 130–140 mm3 mice were vaccinated with the optimal dose of 1 × 109 TU/mouse of Lenti-HPV-07 (n = 7) or a Ctrl Lenti (n = 6) Tumor growth was monitored with electronic caliper b Timeline of tumor engraftment and combinatory treatment with Lenti-HPV-07 and anti-TIM3 mAb When the tumor volume reached an average of 130 mm3 (day 13) mice were randomized and vaccinated with the suboptimal dose of 1 × 108 TU/mouse of Lenti-HPV-07 or a Ctrl Lenti Mice were then treated with anti-TIM3 mAb (clone RMT3–23 A total of 8 injections was given from day 16 to day 36 (200 µg/injection) d Therapy response rates according to RECIST criteria as follows Complete response is defined by the complete eradication of the tumor observed during the time of the experiment Partial response is defined by at least two consecutive decreasing measures during the treatment Progression-free survival (PFS) is defined in all mice to reflect the duration of the response; from the day that tumor reached their maximum size until the day that tumor exceeded the maximum size again e PFS of mice bearing TC1 tumors and treated with Lenti-HPV-07 and TIM3 blocking antibody f Survival curves of the animals shown in (c) Statistical significance was determined using a Log-rank Mantel–Cox test Mice were sacrificed when the size of the tumors reached 1500 mm3 in accordance with the defined humane endpoints Because anti-TIM3 mAb alone had no impact on TC1 tumor growth and Lenti-HPV-07 + anti-TIM3 mAb was more efficient than Lenti-HPV-07 + Ctrl Ig the effect of combination therapy appears to be rather synergistic than additive a Timeline of tumor engraftment and combinatory treatment with Lenti-HPV-07 and anti-NKG2A mAb When the tumor volume reached an average of 120–140 mm3 (day 10) mice were randomized and vaccinated with the suboptimal dose of 1 × 108 TU/mouse of Lenti-HPV-07 Mice were then treated 2-to-3 times a week with anti-NKG2A mAb (clone 20D5 A total of 8 injections was given from day 14 to day 31 (200 µg/injection) c Therapy response rates according to RECIST criteria d Progression-free survival time of mice bearing TC1 tumors treated with Lenti-HPV-07 and NKG2A blocking antibody e Survival curves of the animals shown in (b) *p = 0.0134) in (e) or by unpaired t-test in (d) Mice were sacrificed when the size of the tumor volume reached 1500 mm3 TIM3 or NKG2A blockade alone had no anti-tumor effect in our preclinical HPV-induced tumor model probably due to the absence of TC1 tumor-induced T cells expected to be mobilized by ICI treatment these results show that a combination of lentiviral vector-based vaccination and ICI treatment such as anti-TIM3 or anti-NKG2A mAb therapy despite the induction of anti-VSV-Gind neutralizing antibodies and IFN-γ-producing T cells after a Lenti-HPV-07ind prime a homologous boost with Lenti-HPV-07ind or a heterologous boost with Lenti-HPV-07nj potentiated anti-HPV-07 T-cell effectors to a similar extent It is possible that circulating anti-vector antibodies or systemic T cells do not come in contact soon with the vaccinal pseudoviral particles injected in the muscle these particles are rapidly taken up by local dendritic cells Deemed to act upon the T-cell (re)activation the dendritic cells might rest unaffected by prime-induced anti-vector immunity This could also explain the absence of any negative effect of such immunity upon the homologous boost these results are important for the clinical introduction of Lenti-HPV-07 treatment suggesting unnecessary the separate production of GMP batches intended for prime and boost with distinct VSV-G pseudotyping This considerably facilitates the production set-up and reduces the cost of vaccine for clinical trials our results demonstrate the applicability of NGS to assay T-cell repertoire dynamics following i.m Peripheral blood cells could be used as sample We further propose the use of NGS for in immune-monitoring of patients to be enrolled in the Lenti-HPV-07 Phase I/IIa clinical trial co-detection of anti-vector T cell immunity could obscure the results use of NGS for immunomonitoring does not obviate the need for ELISPOT and intracellular cytokine staining to detect T-cell responses specific to the HPV-07 antigen encoded by the vaccine there are multiple lines of support for anti-TIM3 therapy as an ICI to be either combined to anti-PD1 treatment or to replace it we evidenced enhanced efficacy or synergistic effects of Lenti-HPV-07 vaccination with the combination treatment The results of the favorable effect of these alternative ICI on the anti-tumor effect of Lenti-HPV-07 may be instructive for future prospective Lenti-HPV-07 clinical trials our results validate the proof of concept for the use of anti-TIM3 or anti-NKG2A ICI when combined to Lenti-HPV-07 in further clinical trials given that only 20–25% of cancer patients respond to ICI treatments alone Lenti-HPV-07 is entering a Phase I/IIa clinical trial for the immunotherapy of HPV16/18-related cervical or oropharyngeal cancers The results generated here reiterate the potential benefits of the Lenti-HPV-07 immunotherapy and further elucidate its modes of action against malignant tumors caused by persistent HPV infections The titer was defined as “Transduction Unit” (TU)/ml which is the number of LV particles per ml able to transfer its genetic material inside the reference HEK293T cells by transduction in presence of 8 µM of aphidicolin Six- to 8-week-old female C57BL/6JRj mice supplied from Janvier (Le Genest Saint Isle Mice were housed under standardized light–dark cycles in a temperature-controlled air-conditioned environment in ventilated cages under pathogen-free conditions at the Institut Pasteur animal facilities All mouse studies were performed in accordance with the European and French guidelines (Directive 86/609/CEE and Decree 87-848 of 19 October 1987) after approval of the protocol by the Institut Pasteur Safety Animal Care and Use Committee delivered by the local ethics committee (CETEA #DAP180049 CETEA #DAP190130 and the Ministry of High Education and Research APAFIS#16381-2018080217194542 v1 C57BL/6 awake mice were immunized intramuscularly with 1 × 109 TU of Lenti-HPV-07 contained in 50 µl (Day 0 or Day 28) Mice primed at Day 0 were boosted with the same amount of Lenti-HPV-07 at Day 28 Splenocytes from all individual mice (n = 4/group) were studied at Day 42 (14 days post boost) 100–150 µl of blood were collected on awake animals by submandibular vein puncture into an Eppendorf tube containing 15 µl of heparin Mice were euthanized by cervical dislocation according to predefined endpoints at the end of the experimentation (day 42) or when animals exhibited signs of cachexia Monitoring of tumor growth was performed 2 or 3 times per a week with a digital caliper Tumor volume was estimated as a sphere using the formula V = L × W × W/2 when tumor size reached 1500 mm3 or became ulcerated As described previously45 T splenocyte responses were assessed by IFN-γ ELISPOT after in vitro stimulation with pools of peptides spanning the complete sequences of VSV-Gind (Genscript) or each of the detoxified E6HPV16 or E7HPV18 antigens (Mimotopes) as encoded by Lenti-HPV-07 Splenocytes from individual immunized mice were homogenized Cells were then treated with Red Blood Cell Lysing Buffer (Sigma) washed twice in PBS and counted in a Chemometec (Nucleocounter NC-200) cell counter Splenocytes were then plated at 1 × 105 cells/well in 200 µl of RPMI-GlutaMAX containing 10% heat-inactivated fetal calf serum 100 U/ml penicillin and 100 mg/ml streptomycin 1 × 10–3 M sodium pyruvate and 5 × 10–5 M of β-mercaptoethanol in ELISPOT plates (Mouse IFN-γ ELISPOTPLUS Cells were left unstimulated or were stimulated with pools of appropriate peptide pools at 2 µg/ml of each peptide) or with 5 µg/ml of Concanavalin A (Sigma) as a functionality control according to the manufacturer’s recommendations Plates were analyzed in an Immunospot CTL Immunospot S6 ultimate-V Analyzer (CTL) For the IFN-γ ELISPOT with a stimulation by lentiviral vectors total proteins in concentrated lentiviral vector supernatants were quantified using the micro BCA Protein Assay kit (Thermo Scientific) following the manufacturer’s instructions Neutralization assay was performed using serial dilutions of heat inactivated sera at 56 °C during 30 min HEK293T cells and non-replicative LV particles pseudotyped with VSV-Gind or VSV-Gnj which harbor the reporter luciferase firefly gene serial serum dilutions were incubated with 1.2 to 1.5 × 105 TU of LV particles pseudotyped with VSV-Gind or VSV-Gnj in clear flat-bottom 96-well black plates (Corning) during 30 min with gentle agitation at room temperature in a final volume of 50 μl in DMEM-glutamax completed with 10% heat-inactivated fetal calf serum and 50 U/ml penicillin and 50 U/ml streptomycin (Gibco) The samples were then mixed with 2 × 104 HEK293T cells in 50 μl the transduction efficiency was determined by luminescence using a Luciferase Assay System (Promega) on an EnSpire plate reader (PerkinElmer) using Enspire Manager v4.13 software blood sample from retromandibular vein were recovered in a tube containing 10 µl of Heparin Choay (Cheplapharm) To recover peripherical blood cells from the blood samples red cells were lysed using BD Pharm Lysis buffer (BD Biosciences) following the manufacturer’s instruction For the E7HPV16 RAHYNIVTF-epitope-specific TCR RNAseq analysis CD8+ T cells were then enriched via negative selection using magnetic beads (Miltenyi) and then labeled through immune-staining utilizing antibodies including anti-CD8 (clone 53-6.7 and a RAHYNIVTF-specific H2-Db dextramer (Immudex) The CD8+dextramer+cell population was then isolated via sorting using a BD FACSymphony™ S6 flow cytometer (BD Biosciences) and BD FACSChorus™ Software v1.1 RNA was extracted from blood samples using RNeasy Mini Kit (Qiagen) per the manufacturer’s instructions RNA quality was validated on a NanoDrop 2000c (Thermo Fisher Scientific) making sure that samples have the absorbance ratio 260/230 nm > 2.0 and further using the RNA 6000 Pico kit for 2100 Bioanalyzer (Agilent) TCRα and TCRβ DNA libraries were prepared simultaneously using SMARTer® MouseTCR α/β Profiling Kit (Takara Bio) Normal distribution of each group was tested using a Shapiro–Wilk test (p < 0.05) All two-way ANOVA were performed using a Geisser-Greenhouse correction. Statistical analysis was Prism GraphPad v9. In Figs. 2–5 data were represented as mean values and error bars represent SEM Mann–Whitney unpaired t-test and Log-rank Mantel–Cox test were used to evaluate the statistical significance between groups Further information on research design is available in the Nature Research Reporting Summary linked to this article In-lab scripts were used to generate chord diagram figures in R Scripts are available on request by contacting corresponding author: francois.anna@pasteur.fr Burden of human papillomavirus (HPV)-related cancers attributable to HPVs 6/11/16/18/31/33/45/52 and 58 Inducing immunity where it matters: orthotopic HPV tumor models and therapeutic vaccinations Human papillomavirus-related oropharyngeal cancer Lentiviral vectors as a vaccine platform against infectious diseases Full eradication of pre-clinical human papilloma virus-induced tumors by a lentiviral vaccine Lentiviral vector induces high-quality memory T cells via dendritic cells transduction Persistence of integrase-deficient lentiviral vectors correlates with the induction of STING-independent CD8(+) T cell responses A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4(+) T cell immunity Hot and cold tumors: immunological features and the therapeutic strategies Virally vectored vaccine delivery: medical needs Pre-existing immunity against vaccine vectors–friend or foe Biological differences between vesicular stomatitis virus Indiana and New Jersey serotype glycoproteins: identification of amino acid residues modulating pH-dependent infectivity Quantitative T cell repertoire analysis by deep cDNA sequencing of T cell receptor alpha and beta chains using next-generation sequencing (NGS) Research techniques made simple: high-throughput sequencing of the T-cell receptor Biological controls for standardization and interpretation of adaptive immune receptor repertoire profiling Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells a promising target for cancer immunotherapy Anti-NKG2A mAb is a checkpoint inhibitor that promotes anti-tumor immunity by unleashing both T and NK cells Resistance to immune checkpoint therapies by tumour-induced T-cell desertification and exclusion: key mechanisms prognostication and new therapeutic opportunities TIM3 comes of age as an inhibitory receptor Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity High-throughput sequencing of the T-cell receptor repertoire: pitfalls and opportunities The mouse (Mus musculus) T cell receptor beta variable (TRBV) The mouse (Mus musculus) T cell receptor alpha (TRA) and delta (TRD) variable genes T-cell receptor repertoires share a restricted set of public and abundant CDR3 sequences that are associated with self-related immunity sequence comparison and biological database search NKG2A blockade potentiates CD8 T cell immunity induced by cancer vaccines Vaccination reshapes the virus-specific T cell repertoire in unexposed adults TCR sequencing paired with massively parallel 3’ RNA-seq reveals clonotypic T cell signatures Precise tracking of vaccine-responding T cell clones reveals convergent and personalized response in identical twins Combining next-generation sequencing and immune assays: a novel method for identification of antigen-specific T cells Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer Tim-3 finds its place in the cancer immunotherapy landscape Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints TIM-3 restrains anti-tumour immunity by regulating inflammasome activation Implications of NKG2A in immunity and immune-mediated diseases Dimorphism of HLA-E and its disease association TCR specificity dictates CD94/NKG2A expression by human CTL The tumor microenvironment and immunotherapy of oropharyngeal squamous cell carcinoma Combination of NKG2A and PD-1 blockade improves radiotherapy response in radioresistant tumors A single immunization with a minute dose of a lentiviral vector-based vaccine is highly effective at eliciting protective humoral immunity against West Nile virus Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models MiXCR: software for comprehensive adaptive immunity profiling Download references licensed under a Creative Commons Attribution 4.0 Unported License These authors contributed equally: Ingrid Fert These authors jointly supervised this work: Pierre Charneau conceptualized and designed experiments; I.F. constructed and produced lentiviral vectors and provided technical support; I.F. All authors read and approved the final manuscript are designated as co-first authors due to their equal contributions to this work has a consultancy activity for TheraVectys are inventors of a pending patent directed to the potential of Lenti-HPV-07 vaccination against HPV-induced cancers Other authors declare no competing interests Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41541-024-00894-0 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Meet the Milan studio designing the world’s finest yacht interiors By Belinda Aucott-christie 05/07/2024 Contemporary yacht design has shaken off the shackles of traditional nautical design Now freed of its fusty navy and white uniform yacht interiors are embracing a look that’s more colourful and carefree Tailor-made yacht interiors are also becoming more environmentally sensitive. Italian designer Paola Lenti is at the forefront of this welcome sea change Lenti services some of the best shipyards in the world Each year when she opens her chic pop-up café at the Monaco Boat Show she’s inundated with boat owners clamouring to see her latest collection Lenti’s studio has established a style that combines beauty and longevity in equal measure Her work for prestigious makers and architects includes shipyards such as San Lorenzo (a 63m yacht created by London-based yacht designer Bannenberg and Rowell) It doesn’t seem to matter whether Lenti is producing furniture and soft furnishings for the deck of a super yacht or courtyard of a parterre garden joined the company over two decades ago as CEO Both sisters are possessed of business acumen and a commitment to using high-quality and recycled materials “Sustainability is not a choice,” says CEO Anna Lenti “We believe that when you have to put furniture in an outdoor space we feel that you should do it in a very delicate way We believe the product should not be more important than the surroundings.” The Lenti signature yarn is rope and it is one again and again when crafting everything from sofas to bar stools The Maison’s polephyenyl blends are quick-drying making them perfect for withstanding the elements on board a yacht And while Paola Lenti may be known to work with the 1 percent the company upholds high environmental standards at every step of the production process Their Twiggy yarn is 100 percent recyclable and eco-compatible Despite all the practical qualities of these sun-worthy outdoor designs working together with their research and development team have established name for quality while at the same time establishing a design vocabulary that’s colourful and lyrical It’s a total style that collectors can enjoy fitting together that employs newly arrived refugees to Italy In the last two years they also started working with Edra’s Campana brothers from Brazil to transform unwanted materials from their factory floor into colourful one-off handmade pieces that are designed to minimise waste Discover the entire Paola Lenti collection at dedece.com or visit PaolaLenti.com With a rising emphasis on relaxed holistic living yacht designers are fielding requests for on-board plunge pools By Julia Zaltzman By Robb Report Staff Six standout Australian galleries to know now By Belinda Aucott-christie 26/03/2025 More galleries than ever before are going on the road to participate in art fairs in scene that is rapidly maturing Meet the passionate local owners from around Australia who are energising the creative milieu with the abstract the Indigenous and the generally astounding The art sphere often challenges the myth that married partners should not become gallerists—see Iwan and Manuela Wirth of Hauser & Wirth fame And so it is that Cassandra Bird and husband Fabian Jentsch are rapidly cementing a reputation as one the Australian art scene’s supercouples with their 2023-acquired Potts Point space an expansive four-level heritage terrace fizzing with congeniality making visitors feel like they have popped to a friend’s (expertly curated) home for elevenses Which is no great shock: the property doubles as the duo’s own home respected stints in the Big Apple and Berlin and nine years at Sydney’s RoslynOxley9 Gallery; Jentsch get them excited as we are about those we work with,” says Bird Meander across the property’s wooden floorboards—perhaps diverting for a chat in the communal courtyard that doubles as a social hub and ideas-exchange forum—and you will enter the realm of Perth-born graphic painter Jedda Daisy-Culley who has a hallway and wall dedicated to her work; venture upstairs and deep dive into locally based experimental photographer Laura Moore; head into the basement and peruse the collective works the Tennant Creek Brio out of Warumungu Country in the Northern Territory All 24 of the gallery’s artists unite under the theme of timelessness “We are into investigating quality and showing transformational and breakout work from artists,” says Jentsch “The work we choose must have something that is strong value for us.” Here’s to the sanctity of marriage cassandrabird.com It speaks volumes for the international reach of Indigenous art that D’lan Contemporary opened an outpost in New York long before expanding the gallery beyond its Melbourne roots to set up shop in Sydney founder and director D’lan Davidson is not afraid of expanding his frontiers as a means of hawking Australia’s most vital cultural outpourings; in 2016 he left the Sotheby’s Australia auction house where he was ensconced as head of aboriginal art to launch D’lan Contemporary as the go-to gallery for secondary market First Nations art; and he recently travelled to Maastricht in the Netherlands for the prestigious European Fine Arts Foundation Art Fair promoting a series of Western Arnhem bark paintings and works by Paddy Bedford Davidson has surrounded himself with a team brimming with the requisite Indigenous art smarts including chief curator and gallery director Luke Scholes a mainstay of the Melbourne gallery for the past ten years will show across all three of D’lan Contemporary’s locations “Our exhibitions and all our advocacy work seek to further support and develop the burgeoning global interest in Australian First Nations art and artists,” says Scholes As if further proof were needed of its commitment the gallery donates 30 percent of its profit back to artists and their communities dlancontemporary.com.au Enter Nick Smith’s compact office and you notice how the walls are studded by the artworks of those he represents; this is a man who has a more intimate connection to his stable than the average gallery chief—an instinct confirmed upon discovering that he has invested his entire life savings into the Surry Hills space Smith’s whiteboard is teeming with collaborative projects thought-provoking artists that his outfit—comprised of five full-time staff—is renowned for nurturing but amazing,” says Smith in his typically reserved manner more studious scientist than reengage gallerist “I wanted to contribute to culture in my own way.” The gallery’s current ascension allays any empathetic fears of impending financial doom Smith—who cut his teeth at Philip Bacon Galleries in Brisbane and Sydney’s Sullivan+Strumpf—collaborated with the Australian High Commission in India to represent Darrell Sibosado at India Art Fair ’25 and throughout the year will be partnering with the Sydney chapter of Soho House to host a series of private viewings and artist studio visits he now splits his time equally between private and public projects often mentoring artists at all stages of their creative journeys It’s that feeling of progressions and going somewhere that I love,” says Smith nsmithgallery.com almost impossible—to imagine Palas founders Tania Doropoulos and Matt Glenn frantically trying to scoop up whoever is flavour of the month on Sydney’s perennially shifting art circuit Here are young gallery partners prone to a slower instead recruiting a tight roster of internationally famed artists and choosing to nurture relationships that have been years Case in point: video performance maestro Shaun Gladwell who represented Australia at the 2007 Venice Biennale (a 20-year affiliate) and Melbourne-based artist and noise-musician Marco Fusinato (15 years) who also flew the artistic green and gold at the same festival in 2022 Add to that list Canadian multi-media artist Tamara Henderson and Irish sculptor Eva Rothschild and it is clear Palas have a formidable roll call to lean on “We’re investing a huge amount of time into their processes as art makers,” says Doropoulos we’ve got really good working relationships with other galleries throughout the world.” For its founders the Palas gallery—which opened in Sydney’s resolutely hipster Waterloo suburb just over a year ago with a silkscreen painting medley by the aforementioned Fusinato—is somewhat of a flag-planting endeavour on home soil: both earned a certain amount of their stripes overseas—Doropoulos as former artistic director of Frieze London and Frieze Studios Australian art disciples will no doubt be praying for a long domestic residency palas-inc.com If Sotiris Sotiriou’s consciously balanced ensemble of black Saint Laurent suit single gold chain and flash of bare chest are anything to go by the Coma gallery founder wields a sharp eye—a handy attribute to have when your career depends on identifying aesthetic clout From humble beginnings in 2016 in a subterranean road space next to Elvis Pizza on Sydney’s New South Head Road before fully blooming at his current space in up-and-coming Marrickville The predominantly light-industrial area has witnessed around half a dozen new gallery debuts in recent years filled as it was with hip young Inner West couples sourcing bold suggests Sotiriou has timed his arrival to perfection February’s opening exhibition was hosted by Australian (but Santa Fe based) figurative painter Justin Williams whose approach riffs on the folkloric traditions of Russian and Polish art rich with symbolism and psychological details; this work forms a striking counterpoint to the abstract expressionism of other Sotiriou recruits such as Zara June Williams and her partner Jack Lanagan Dunbar who had a spell selling to wealthy clients at Nanda Hobbs says that private clients now make up most of his customer base as he prepares to attend three international art fairs he estimates his artistic head count to increase by 30 percent also point you in the direction of a fine tailor comagallery.com Always an unmissable highlight of the automotive calendar Robb Report ANZ’s annual motoring awards set a new benchmark among glorious Gold Coast tarmac By Horacio Silva 24/03/2025 our motoring sages and VIP guests embarked on an exhilarating journey from Surfers Paradise to Brisbane and back again—traversing an irresistible selection of terrain in our exotic rides from deserted rainforest-lined b-roads to testing mountain switchbacks with dizzying—sometimes heart-in-mouth—views over the southern Queensland peninsula And as befitting an event starring the crème de la crème of auto marques we did so while savouring the best in luxury and gastronomy—capped off with an extraordinary superyacht experience at Sanctuary Cove The ten contenders for the Car of the Year were not the only dream machines on show The first day’s adventure kicked off at the Langham Hotel and included a midday pit stop at the glorious Beechmont Estate where our fleet of drivers were greeted by a stunning array of vintage cars exhibited in a concours d’elegance-style display The sumptuous feast for the eyes on offer at Beechmont a quaint country village located between the Lamington Plateau and Tamborine Mountain was followed by a meal for the ages prepared by executive chefs Chris and Alex Norman at the property’s hatted restaurant with our drivers—all sporting Onitsuka Tiger’s new driving shoes—hightailing it to Brisbane and The Calile Hotel a property which has been scooping accolades like Jay Leno collects supercars After some much needed relaxation by the pool that evening the drivers and press were joined by local luminaries in the hotel’s private dining room Over an extravagant banquet they got to compare notes on marvels of engineering and design that they’d had the chance to pilot all day They were also treated to a showcase of spectacular Jacob & Co timepieces and Hardy Brothers jewellery and an elegant sufficiency of 40-year Glenfiddich whiskey served in gold cups worth $60,000 a pop It made for animated discussions and more than a little impromptu shopping And did we mention the luxury yacht experience After a full itinerary of adventures on the road the day ended with an invigorating late-afternoon of luxuriating aboard two new Riviera Yacht releases—the 6800 Sport Yacht and the 585 SUV—where our intrepid drivers and assorted press got to literally and figuratively take their hands off the wheel and make a case for their car of the year But who would take centre stage on the winners’ podium Rolls-Royce Spectre Aston Martin Vantage Bentley Flying Spur McLaren 750S Mercedes-AMG SL634MATIC+ Maserati GranTurismo Porsche Taycan Turbo S Ferrari Purosangue Cruise along to robbreport.com.au/events for more supercars and luxury motoring Mercedes-Benz’s CEO Ola Källenius is expert at racing a nearly four-tonne truck across a frozen lake Can he steer the marque’s EV-focused future as adeptly By Ben Oliver 26/03/2025 a premade sandwich and a carton of juice) and speaks in fluent German to the mostly Austrian engineers who spend months in this bleak locale ensuring that the company’s new models can cope with the types of conditions in which vanishingly few customers will ever actually drive They discuss the truck’s handling on ice and the progress of its test program Källenius compliments them on the car’s dynamics—how stable it remained even at speed how safe he felt driving it—and asks them how long they’re here “There are some harsh realities to this job and to the car industry,” he tells me later “But this is what I love doing: spending time with our designers or driving with you on an ice-lake in Sweden I wanted to congratulate them on what they’ve achieved We get to enjoy a nice couple of days here Källenius might tower over most of them physically but there’s nothing in his demeanor that hints at the disparity in their corporate statuses Nor is this the kind of place you’d expect to find the head of one of the world’s great luxury brands: a man paid roughly $22 million last year to lead the 166,000 employees of a company valued at around $75 billion invented the motor car and whose genuinely iconic logo has graced the nose of everything from popemobiles and Lewis Hamilton’s Formula 1 racer to the most expensive automobile ever sold at auction investment analysts Bernstein described Mercedes-Benz under Källenius’s reign as a “four-wheeled cash-generation machine” But the celebrated car marques are not like luxury brands that make watches or couture or accessories or Champagne Look beyond the alluring badge and bodywork for a moment: the objects Mercedes-Benz and its rivals produce are insanely complex ever-changing and hugely capital-intensive—and must succeed in an utterly cutthroat market Their impact on the environment and the economy has always made them perennial hot-button issues politically But the electrification of the automobile has put these companies in the geopolitical crosshairs like never before as governments swap tariffs and risk a global trade war to ensure that they keep their respective shares of the car industry even as it undergoes an unprecedented transformation Add the impact of electrification to Källenius’s own manifesto for Mercedes-Benz and this storied marque is likely to change more in the next decade than it did in the previous 138 years “It’s a once-in-a-century transformation,” he says “We are reinventing our original invention.” So who is the guy steering Mercedes through this tumult Källenius has sat for plenty of interviews in his five years as CEO (his second five-year term is set to conclude in 2029) but this is the first time that he has offered anything more Robb Report was invited to spend the weekend with him in Arjeplog the tiny northern-Swedish town whose population swells fourfold each winter as the global car industry descends to test its secret new models on the area’s frozen lakes but to reduce the chance of its future lineup being scooped Mercedes rents its own private expanse of sheet ice from a local landowner I watch Källenius as he test-drives the electric G at his empire’s oddest and most northerly outpost meets local staff and records social-media footage more secret new electric AMGs that I am definitely not allowed to see whose debuts are much further off and which remain hidden beneath their heavy covers outside the workshop Källenius has a reputation for being fearsomely intelligent but also not the type of hyper-alpha asshole who too often comes to lead a carmaker I see that sharpness not just in the logic of his answers I’m not sure I’d want those piercing blue eyes and that high-wattage intellect turned on me in a meeting if I didn’t have my numbers straight It comes through in the easy egalitarianism he displays with the engineers in the workshop or the way he’s enjoying a casual dinner and a beer with a long table of employees of all stripes when I first arrive at the unglamorous Silverhatten hotel where he’s staying—a glorified bunkhouse for the United Nations of engineers and test-drivers who flock here This is clearly a leader who sees the obligations of his office as clearly as its privileges: an attitude underpinned by a natural Nordic modesty and reserve “I guess your personality is something that forms in younger years and I’m not sure you can fundamentally change it,” he tells me over coffee one morning and maybe most Swedes are not kick-the-door-down types I believe this should be true for anybody who is at Mercedes or has the privilege to lead Mercedes: We are custodians of that star for a brief moment It’s my job to hand it over safe and in better condition but the brand will look very different by the time this person is done with it in 2029 And you can add loyalty to that list of his qualities: Källenius has never worked anywhere else having joined Mercedes-Benz in 1993 straight out of the Stockholm School of Economics where he founded an American football team called the Traders he studied tapes of the Chicago Bears and New England Patriots in order to write the team playbooks he was a finance guy at first; an early posting took him to Alabama to help set up the Mercedes factory in Tuscaloosa where he became—and remains—a Crimson Tide fan he was put in charge of the Mercedes-Benz SLR McLaren supercar project; two years later he was given control of Mercedes-Benz High Performance Powertrains the firm’s in-house Formula 1 engine-maker After a year as vice president and CEO of Mercedes-Benz US International back in Tuscaloosa he was recalled to Germany in 2010 to become vice president and managing director of AMG Mercedes’s high-performance road-car division Then came two board positions to prove his breadth of ability—sales and marketing followed by research and development—before he ascended to the top job in 2019 at the age of 50 The electric G-Class we’re about to drive together (now officially if awkwardly named the “G580 with EQ Technology”) is a neat encapsulation of many of the things Källenius has tried to do at Mercedes which fits his initial plan to make everything electric—“where market conditions allow”—by 2030 with a starting price in the US of $161,500 (around $257,000 Another critical if controversial part of his manifesto is to shift Mercedes upmarket; he spun off the truck business early and is currently in the process of dropping high-volume low-margin models including the A- and B-Classes he wants new models to still feel like Mercedes vehicles even if the design that underpins them is radically different from what came before And the G-Wagen—with its gloriously anachronistic overengineering that you can feel and hear every time you clunk a door shut—epitomises the Mercedes ethos whether the vehicle is gas or electric Other new Mercedes EVs go much further in their innovation gaining greater advantage from their electric drivetrains given that they were designed as EVs from the outset They use Mercedes’s new MB.OS operating system with built-in AI and receive fresh design cues inside and out—not least the mad almost full-width hyperscreen user interface—rather than the same upright rectilinear lines first sketched out to suit the needs of farmers and soldiers when the G-Class was introduced 45 years ago and it’s pleasing to be driven in it by the CEO on whose watch it was conceived and executed this is an electric G,” he says as he drifts it across the glassy frozen lake The most important box for any G-Class to tick is the Schöckl mountain in Austria to earn that Schöckl-proven plaque they all have I did five trips up and down it in the electric G in the autumn I felt it could do the Schöckl best of all.” and with McLaren have turned this “spreadsheet guy” into a skilled driver though most Swedes seem to have the ability to safely slide a car on ice coded into their DNA Even with the G sideways at around 110 km/h a plume of snow and ice billowing high behind it Källenius has enough spare mental-processing capacity to adjust the screen settings while telling a funny story about the very first time an electric G even crossed his mind when the company was first showing the revised G-Class Arnold Schwarzenegger came to the unveiling and asked Källenius’s predecessor and one of my colleagues turned to me and said ‘Do we even have an electric G in the plan?’ I said that I guessed we did now.” Those less keen on electric cars than Arnie and Ola might be pleased by the fact that the ambition to be battery-only by 2030 has fizzled fast Mercedes now predicts that EVs and plug-in hybrids will account for only half of its sales by the late 2020s and the company is refreshing its range of gas engines to keep them relevant and selling deep into the 2030s This is a systemic issue and no reflection on Mercedes products; Källenius has always averred “where market conditions allow” “The early adopter phase is over,” he tells me and not do anything.’ Because if you put product into the market that is so convincing that most customers go but iPhone 4 looks pretty good,’ you can get very quick ‘I’m not going to set sail here; let’s wait and see what the weather does,’ all the other boats would be out on the ocean But if buyers are going to be sold on EVs by the technology rather than by brand power what does Mercedes’ 138 years of history count for With customers attracted to new EV marques that are able to innovate unconstrained by precedent—and one of those brands having a market cap 7.5 times that of Mercedes despite selling a few hundred thousand fewer cars per year—does heritage become a liability rather than an asset “We also do unconventional things,” Källenius insists “With blow-your-mind–type features like the crazy hyperscreen in the EQS and the EQE a lot of people are looking at Mercedes who perhaps didn’t look before We are one of the biggest automotive sponsors in e-sports Formula 1 is off the charts; 53 percent of F1 fans are between 15 and 35 When we do crazy things like the G-Class collaborations with Moncler or the late Virgil Abloh you go beyond the traditional auto crowd to one that buys from other luxury brands My test is if one of my kids sends me a picture and goes I wonder how the former finance guy now handles running one of the world’s great luxury brands and to whom he looks for inspiration He acknowledges that he meets with Bernard Arnault at LVMH and Jean- Frédéric Dufour at Rolex but is coy about the nature of their discussions “We also reach out to people in other luxury businesses to understand how they think,” Källenius notes “I had the good fortune to meet Brunello Cucinelli It’s one of the most beautiful villages I’ve ever seen sometimes not emphasising the brand so much A fine gentleman like that has a very clear understanding of what luxury means in his business We brought some secret new-vehicle designs to show him and to get his input.” high-capital-investment good like a car to a piece of clothing,” he adds But good chefs eat in each other’s restaurants even though they have a totally different style of cooking I sense a slight frustration from the hyperrational Swede—perhaps that he believes he has gotten the recipe right but has to wait a bit longer for diners’ tastes to catch up the new Mercedes EVs will be the best cars the company has ever made are as busy trying to get their heads around this brave new world as the automotive CEOs are “This is definitely the most transformative decade since the inception of the company,” Källenius agrees The Swabian engineers who founded Mercedes didn’t look at the horseshoe and think ‘How do we make this lighter to make the horse run faster?’ They wanted to get the horse out of the equation and do something new We’ve always looked through the windscreen Two restless entrepreneurs build a Belizean island paradise especially for those “aha By Katie Kelly Bell 26/03/2025 Though he’s supposed to be in what he calls his “play years” now Knoxville-based real-estate entrepreneur Steve Hall still finds himself working on vacation he got the itch to build something new and started meeting with developers and together they acquired an isolated tract on Placencia Caye a private island just five minutes by boat from the mainland they’ve recently started welcoming guests to Prana Maya wellness-focused retreat that enjoys expansive views of the Caribbean Sea the island’s lagoon and the Maya Mountains “We designed everything to inspire people,” Hall says of the property “Every aspect of the resort is intentional Every service we offer is designed to create that ‘aha The property includes seven three- and four-bedroom villas featuring locally carved wooden doors secluded structures are sited to prioritise views of the water and every bed at the resort is fitted with a custom grounding mat designed to replicate a connection with nature; some studies suggest they promote mental and physical well-being Belize’s tropical landscape is the catalyst for getting outdoors Its unique saltwater flats give sport-fishing aficionados a bucket-list opportunity: catching what the International Game Fishing Association calls the Grand Slam—permit So Hall and Keener recruited High Adventure Company a global outfitter with 30 years of guiding expertise to take guests on exclusive angling excursions If you’re in search of less rugged activities The design team placed it on prime real estate: the Inn’s top floor which has 360-degree water views and 5 m ceilings five private treatment rooms and a sound-therapy space You can also enjoy Prana Maya’s private beach the only sandy stretch on the island that isn’t shared with another property executive chef Liesel Kirste cooks with indigenous ingredients—many sourced from the resort’s four-hectare farm The menu includes elevated fare such as locally caught lobster Even components of more casual dishes are made from scratch: at the Island Club—with its outdoor kitchen lawn games and forthcoming palapa-shaded pickleball court—the ketchup and mayonnaise are made in-house That gives the culinary team the flexibility to design a bespoke menu Prana Maya is the expression of a million small details (down to the reef-safe spa products curated by a Belizean supplier) and the location’s natural majesty see the spectacular views of the Caribbean turn another direction and see the beauty of the Maya Mountains it is such an awesome and almost overwhelming feeling,” Hall says One he is determined to share with everyone who visits Top image: Benedict Kim/Courtesy of Prana Maya The dress watch is back and more laid-back than ever Here’s how to rock your Cartier and Piaget pieces with casual looks By Paige Reddinger 24/03/2025 After the seemingly never-ending hype around steel sports watches But it’s not just the average 42 mm dress watch that’s sparking interest (although but also funky vintage diamond-accented timepieces or small-sized actor Paul Mescal was spotted on the red carpet of the Annual Academy Museum Gala wearing a Cartier Tank Mini with his tux while sports legend Dwyane Wade wore a 28 mm diamond Tiffany & Co Eternity watch with his black tie ensemble to the same event While these guys were wearing dress watches in their intended setting here we show you how to make a dress watch work for casual weekend wear too Try dabbling in unexpected pairings like an army green Ghiaia safari jacket with a vintage Chopard Happy Diamonds timepiece or Breguet Classique Ref 7147 (the ultimate dressy timekeeper) with a Louis Vuitton sweatsuit and a Brioni overcoat Anything goes these days and the more unexpected the timepiece It’s good news all around—for your wardrobe and your investments in the vault sign up Download the app loving son of Kelly Hogan Lenti and Michael Lenti and cherished brother of Peter and Benjamin passed away suddenly on June 12th.  Luke was born on May 16 Illinois.  He spent his childhood growing up in Chicago (Lincoln Park and Edgebrook) and Park Ridge Illinois.  Luke’s greatest joy was playing sports with his brothers and friends in elementary and high school.  He graduated from Maine South High School as a proud member of the Class of 2012.  Luke wore #42 and played linebacker and full back for the Maine South Hawks where he was as starting member of the 2009 Class 7A IHSA State Football Championship Team that went undefeated on the season.  He also was a member the 2010 Class 7A IHSA State Football Champs Luke also attended DePaul University.  Luke loved to fish enjoyed water sports and body building and listening to music.  He will be forever remembered for his big heart contagious laugh and his ability to make others laugh with him Luke was preceded in death by his grandparents George and Bonnie Hogan (Banzer) and Rose Lenti (Frangella) his great grandparents George and Irene Hogan He is survived by his grandfather Frank Lenti great aunts Patricia Winesburg (Hogan) and Cheryl Henning (Banzer) great aunt and uncle Gary and Barb Banzer David and Kelly Lenti.  Several cousins Visitation will be held Friday at Cooney Funeral Home located at 625 Busse Hwy in Park Ridge where masks must be worn inside and social distancing restrictions will take place Visitation times are as follows: 2:00 p.m.-5:00 p.m A private funeral Mass limited to immediate family only will be held Satuday at St For information please call 847-685-1002 or visit www.cooneyfuneralhome.com  1 E. JacksonChicago, IL 60604newsroom@depaul.edu famous for its outdoor furniture and exuberant color schemes is celebrating its 25th anniversary with new releases and as-yet-undisclosed festivities “Color is my legacy,” says designer Paola Lenti It’s just how my mind works,” she continues describing the probing meditations on color that have come to define her oeuvre Lenti has experimented with striking pigments many of which she has gradually adapted into her signature yarns and applied to seating and rugs for both indoor and outdoor environments recyclable plastic that features Lenti’s Twiggy yarn giving them an irregular color structure that produces mélange and other patterns that are impossible to predict or replicate Lenti moved operations to new premises in the well-known manufacturing center Meda who handles the company’s administrative and marketing functions she has committed to advancing and utilizing innovative manufacturing techniques like using Diade for the new Giravolta space-dividing panels the result of four years of intensive research also epitomizes the Lentis’ focus on materials experimentation now offered in 50 shades that can be combined to create almost 300 distinct hues has become essential to the company’s standing in the outdoor furniture market modern engineering practices and color palettes need not conflict with a local Her collections fuse several sensibilities and approaches: Among them Lenti lists “protecting our way of working and sharing synergies and desires so that artisanship and industry always meet.” (The company also emphasizes local sourcing and manufacturing; except for her line of hand-tufted rugs all of Lenti’s products are made in Italy.) At this summer’s Venice Architecture Biennale the company sponsored the installation Freespace a foray into the highminded world of global architecture In a colorful juxtaposition of old and new and Otto contemporary seating pieces—all available in an array of color options—within the centuries-old Giardini and Arsenale spaces (on view through November 25) the brand is already planning a celebration of its 25th anniversary next year (Details have been kept under wraps—a move to be expected “Colors have always been an enormous influence and constant presence in my daily life,” Lenti reflects “I don’t remember a time when I viewed the world in black and white.” Given her decades-long development of exuberant and surprising color schemes it seems certain that this studied and highly personal variegation will continue to weave throughout Paola Lenti’s work You may also enjoy “Psychoanalyzing the 8 Best Pavilions of the London Design Biennale.” Subscribe to our mailing list to receive the latest updates subscription deals delivered straight to your inbox Sio Gene Therapies (Sio), formerly known as Axovant, intends to stop  development of AXO-Lenti-PD, an investigational gene therapy for Parkinson’s disease Sio will return the global rights to develop and market the therapy to Oxford Biomedica, which licensed the treatment to Sio in 2018 The announcement comes on the heels of the resignation of Sio’s CEO and the deprioritization of the program due to constraints on resources needed to advance the therapy Although Oxford Biomedica has no plans to continue developing AXO-Lenti-PD, they will out-license it again to a suitable partner with sufficient resources and funding for further development, the company indicated in a press release harmless virus to deliver three genes that provide instructions to make key enzymes that generate dopamine Dopamine is the nerve cell-signaling molecule produced at low levels in Parkinson’s patients The investigational therapy is designed to provide sustained dopamine levels after a single administration Oxford initially completed a Phase 1/2 trial of ProSavin (NCT00627588) which was well-tolerated and significantly improved motor function at six and 12 months in Parkinson’s patients These benefits were sustained for up to four years in most participants AXO-Lenti-PD demonstrated increased production of the key enzymes and fivefold greater potency in improving movement and behavior compared to ProSavin After Oxford licensed the therapy, previously called OXB-102, Sio sponsored SUNRISE-PD, an ongoing Phase 1/2 clinical trial (NCT03720418) evaluating AXO-Lenti-PD in adult Parkinson’s patients Part A of the trial investigated appropriate doses for Part B in which patients were assigned randomly to AXO-Lenti-PD or a sham procedure to serve as controls Two participants were first treated at a low dose, which, after one year, demonstrated a good safety profile and eased motor symptoms during “off” periods when Parkinson’s medications do not effectively control symptoms Better scores on the Unified Parkinson’s Disease Rating Scale (UPDRS) Part II “Off” score which assessed the activities of daily life A second group of four participants also showed a good safety profile with no serious treatment-related adverse events reported after six months Among the two patients with available UPDRS Part II “Off” data mean scores dropped by 21 points — a 40% improvement in motor function compared to pre-treatment it will continue to focus on developing and manufacturing gene and cell therapies as a contract research organization “Oxford Biomedica’s goal is to become an innovative global viral vector leader that provides solutions to cell and gene therapy for their process development and manufacturing needs across key viral vectors,” said Roch Doliveux “The Parkinson’s programme is non-core to our strategy.” This site is strictly a news and information website about the disease This content is not intended to be a substitute for professional medical advice Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition Never disregard professional medical advice or delay in seeking it because of something you have read on this website SS: Where do you find inspiration for your collections? PL: I can find inspiration in a good book or a work of art, architecture or design from the past. But it can also bubble up in moments of stillness and tranquility. If you learn how to listen to nature, you can discover an inexhaustible wealth of information. PL: Our approach to design from our earliest days has incorporated our commitment to a very precise set of ecological ethics that, unfortunately, has now become a real necessity. We start by fully understanding and respecting the inherent properties of each material, using only those that are 100 percent recyclable or recycled, industrial or natural (never from animal sources though) and then process them without chemical substances harmful to living beings and the environment. SS: What was the transition from oudoor to indoor furniture like? PL: Having begun our entrepreneurial path with indoor accessories such as rugs, we extended our research and experimentation in the last few years to include products and architectural elements, which, layered together, can create a holistic environment, sensitive to its setting. We have brought the comfort of indoor seating outdoors and the easy informality of outdoor living indoors. Sign up to our newsletter for the latest arts and culture updates Paola Lenti and Nendo unveil 'Hana-arashi' a series of sustainable furnishings inspired by Japanese culture at Milan Design Week 2024 a breath-taking moment able to bring people together The collection has a strong connection to Japanese culture not only in its reference to the cherry blossom trees but also because the forms of the pieces are informed by ancient samurai armours The petals that fall down the trees inspired the colourful cut-offs selected by the designer who carefully combined them in different chromatic compositions metaphorically referring to a second nature 'The starting point for the collection is the Maris mesh fabric developed and produced exclusively by our company for outdoor collections,' says founder Paola Lenti 100% polypropylene waterproof material is available in 180 colour hues avoiding the use of secondary materials such as sewing threads or adhesives 'Further experimentation revealed that by tweaking the temperature and heating time specific section of the fabric can be hardened to increase its strength thanks to alternating opacity and transparency.'  for which Nendo founder Oki Sato has a great respect the briefs we receive from the brands and companies are based on their respective features and strengths the project started when we were shown a small piece of the material rather than a brief to design a specific item or use a technology It was a piece of polypropylene mesh material that they used in their outdoor furniture,' recalls Sato 'They also showed me a sheet of material that is rigid and marbled in colour I had the feeling that there were countless 'in-betweens' of the two features of this material And I still vividly remember how excited I was that it would surely be an interesting project.'  Lenti adds: 'Starting from unique fabric remnants with curvilinear form Nendo has carefully shaped them by folding and wrapping them on themselves to create products featuring high aesthetic and design value: it is indeed the nature of the material to determine the form of the object – lamps and baskets – without compromising the delicate texture of the fabric and its recyclability.' It is well known that Sato loves to investigate different 'trial and error' (also the title of a 2012 exhibition) before taking the decision to commit to a specific project. '[After] getting back to my studio in Tokyo I repeated experiments with the material in different ways whereby the necessary strength and soft texture were retained by applying the right amount of pressure and heat dedicated equipment was also developed to produce this collection and we feel that this unique process is what makes this project so fascinating.' Sato was charmed by his collaboration with Paola Lenti: 'to simply use things over and over again designers should be required to draw out new characters and values from the materials by recreating them I feel that this will be one of the important qualities required of the designers of the future.' The Nendo collaboration with Paola Lenti is on view from 15 to 21 April, as part of Milan Design Week 2024 Some of the waste material that inspired the collection The seating collection includes a range of giant bolster cushions and pebble-shaped divans each handmade using different recycled fabrics and threads Anna Lenti and Humberto Campana with pieces from the ‘Metamorphosis’ collection Bright threads discarded during the production process Italian brand Paola Lenti and Brazil’s Estudio Campana stay in the pink with an eco-friendly and socially responsible debut collaboration and aims to raise awareness of the future of sustainable productions and the beauty of materials with past lives developed by the Brazilians in close collaboration with the company are made of waste pieces of carpet or textile At the start, the brand’s eponymous founder, Paola Lenti – a designer who works in tandem with her sister Anna, a nuclear engineer – sent a huge box full of small fragments of colourful fabrics to Brazil The Campanas called it a ‘treasure’ There were further reasons for their enthusiasm: ‘We were intrigued by the possibility of working with a global company that holds high standards at every step of the process We were touched by their acknowledgement of our creative process reflected by a genuine openness to integrating the Campana gaze into this collection,’ they say ‘What could a simple piece of rope be turned into How could we play with colours?’ wondered Paola Inspired by nature and named after various types of insects the resulting collection transforms unwanted materials into one-off pieces that take on organic forms; each handmade piece is slightly different depending on ‘the catch of the day’ an atelier in Como that focuses on providing opportunities for women and men at risk of social exclusion was put in charge of part of the production: ‘Beauty cannot and should not be separated from ethics as well as consumption?’ reflects Paola It’s an ethos that resonates with the Campanas we founded Instituto Campana to offer work to different communities from independent artisans to vulnerable people,’ say the brothers we are working on an old dream of ours: building a park in our hometown of Brotas that merges art with nature We planted 20,000 native trees in the past 20 years aims to restore the Atlantic Forest that once covered this region It will be a space for healing and contemplation.’  The two pairs of siblings also found a common enthusiasm for colour a thousand possibilities,’ Paola says of her practice transforming playful shapes into poetic and vibrant furnishings A flamboyant colour palette and forward-looking design are the foundation of the brand It has since expanded internationally and become an industry leader thanks to its research into natural materials The Lenti sisters have always been devoted to their quest for high-quality recycled materials which is 100 per cent recyclable and eco-compatible a German fibre made entirely from plastic waste that serves as furniture fillings the brand continues to innovate and exemplify a conscious design the Campana brothers have been pioneers in sustainable design for over 35 years creating objects that reflect their heritage and local traditions Since their ‘Favela’ chair in 1991 they have created furniture that mixes rural features with colourful Brazilian urban views and juxtaposes the processed with the found Inspired by everything natural and organic craftsmanship and artistry with sustainable ‘Metamorphosis’ marks the first collaboration between the designers and Paola Lenti although geographically and culturally distant have found mutual ground in their work and lives – at times by chance at others because of conscious and shared professional choices her sister and the Campanas are ‘linked by a series of coincidences’ while his brother Fernando and my sister Anna are Taurus an astonishment for the aspects of life that empower us to always seek out beauty.’  The Campanas add: ‘Paola is a joy to work with She brings humanity and a certain lightness to the table that allows things to flow in harmony.’ Beyond the seating designs their partnership has also resulted in a film titled Che Spreco Rinunciare (What a waste to give up) the film presents a fairy tale that explains how beautiful recycling can be.  VIEW GOOGLE MAPS Former Athletics Director Jean Lenti Ponsetto Honored as Member of NACDA 2021 Hall of Fame Class3/31/2021 12:09:00 PM | ATHLETICS Honorees will be recognized in conjunction with the 56th Annual NACDA & Affiliates Convention to be held virtually on July 27-28 Esteemed Italian design company Paola Lenti has recently expanded its North American footprint bringing its ultra-chic offerings to a sprawling flagship in sunny South Florida following new locations in California and Massachusetts “The Miami store is designed as a concept house where from the smallest accessory to the architectural ensemble we present our global design philosophy,” says CEO Anna Lenti which made its debut during the most recent Miami Art Week with new pieces by the Campana Brothers is located in the city’s lively Wynwood neighborhood known for its abundance of street art and the famous Wynwood Walls polished concrete floors and neutral walls offer the perfect complement to vibrant vignettes featuring the brand’s colorful furnishings and accessories Paola Lenti teamed up with partner Casual Furniture Group the flagship is adjoined by a lush 4,000-square-foot garden planted with palm trees and other native flora The aim is not only to meet the growing demand in the residential sector thanks to Miami’s recent surge in popularity but also to create a base for drawing in yachting professionals by showcasing the company’s array of luxurious outdoor furnishings with its elevated humidity and increased exposure to UV rays will also give us the ideal opportunity to showcase the performance of our products,” adds Lenti “Created to withstand even the harshest conditions our technical yarns and exclusive materials have been particularly embraced by the yachting sector where very high resistance standard are requested.” Among the new introductions is the Jardín collection initially conceived as a cultural undertaking that transcended a simple furniture collection the line was inspired by the organic shapes imagined by visionary Cuban designer Clara Porset for the Acapulco Hotel Pierre Marqués in 1957 and later on presented at The Milan Triennial XI Paola Lenti reinterpreted this seminal project while maintaining its original energy who manages the Clara Porset Archive in Mexico the brand populated the showroom with pieces from the eco-chic Metamorfosi collection which debuted at the 2022 Salone del Mobile and was designed by Estúdio Campana’s Fernando and Humberto Campana the latter of whom passed away in December Featuring a special array of unique pieces—five seating options and one tapestry—that blended art and design the collection represented an important step in Paola Lenti’s commitment to becoming more environmentally friendly across design and production the socially-responsible pieces utilize remnants otherwise destined for landfill and provide employment opportunities for those at risk of marginalization Conceived by both brands as a way to be more environmentally conscious of using raw materials this collection furthers a harmonious dialogue between innovation Visit Paola Lenti Miami at 3026 N © 2023 Hudson One Media, LLC. All rights reserved. Privacy Policy Paola Lenti owns the accomplishment of blurring boundaries between interior and exterior spaces reminiscing her early association with colours Venti worked with Professor Jorge A Vadillo López founder of the Clara Porset Archive at the National Autonomous University of Mexico to create a soulful rendition of the Mexican designer's timeless furniture pieces while keeping the combination of tradition with modernity intact The Jardin Collection is all set to steal the spotlight at the upcoming Milan Design Week 2022 the Italian entrepreneur expresses her design philosophies as a vibrant rendition of nature in all of its glories you have been a strong believer in simplicity and instinct What role have these played in your creativity and craft I keep in mind that no superstructures are suffocated by what is unnecessary Simplicity and balance are two features that are strictly connected and are immensely important and though achieving harmony between utility and beauty is never easy it can free the project from the conventions of the moment one must respect materials for what they are and for what they express Understanding their values and contents means recognising and highlighting their quality STIR: How would you describe your relationship with textiles and how has it evolved over the last two decades of your practice Paola: I have always liked working with fabrics while always being open to novelties and everything that intrigues me I focus my attention on the natural and spontaneous aspects of materials such as stone on the artisanal processes applied to them trying to update them with new and less conventional finishes you often cast the same colour in ethereal palettes infused with subtlety and lightness Take us behind your process of nuance and creation Unless the colour stems from the very nature of the materials wherein it acts as a crucial guiding aspect for the creative process Colourful variations on the different materials allow us to make notable products This enables us to design wholesome indoor and outdoor settings in sync with one's expectations and the most suitable solutions Our company's strength lies in the ability to give creative customisations The chromatic choices we make do not strictly link to a particular product or collection These choices are made to find the right colour in the right place the one that in a specific moment and a specific context can give the most pleasant and correct vibration Paola: One of my earliest memories is that of me as a child playing with two sheets of coloured paper one blue and one orange - two contrasting yet complementary colours Sometimes I see myself as that little girl who plays with those coloured sheets exploring herself in the same images and contrasting shades I recall a sense of lightness and freshness but I feel fortunate to have remained what I once was I am grateful for a life that despite everything has not changed me STIR: In what do you currently find your strongest inspiration Paola: I am a curious person and have always wanted to explore things in-depth to understand their true nature. For me, nature plays an important role and I have already thought of everything. We need to know how to listen to it to see what solutions it offers. Apart from nature I rely on books, art, architecture and design works from the past representing an inexhaustible wealth of information Inspirations often come also from inner silence and tranquillity STIR: Nature and comforting curves form an important part of your style Paola: Craftsmanship works in hand with technology to impart fundamental and essential characteristics This interconnection tends to make the technical aspect of the product less aggressive giving the users a sense of relaxation and tranquillity This collaboration harmoniously combines tradition and manual ability with advanced technical solutions Italian hand-working techniques are an inexhaustible source of inspiration We have always tried to enhance their values while recognising and highlighting their qualities and characteristics you have worked independently from the time you created your very first installations What are your views on the current collaborative landscape I have had my ideas and I have never been interested in following others' paths I commit myself to aiming for the best without compromising creating my professional and industrial path which I still follow today with the same conviction and perseverance as in the beginning I have learned to work and cooperate with realities I have always considered the exchange of knowledge experiences and cultures a positive moment of growth By sharing different experiences and giving weight to each one’s skills STIR: What has been the most memorable turning point in your career Can you name some of the collections that personally impacted your journey Paola: The decisive turning point came in 2000 when my sister decided to help me in elevating my small activity to the platform of an industrial company She took over the management and gave me a chance to focus on designing I think the most notable moment was the introduction of Rope - the outdoor high tech yarn which enabled our company to become what it is today It has allowed us to take a refreshed path which is still one of the featureful characteristics that make us different from others This year we celebrate the first 20 years of Rope with a lens on the future that will bring us many novelties STIR: How did you achieve a successful marriage of fabric and furniture and what are the lessons learned in that course our philosophy is to design and produce comfortable We have created a fresh collection of fabrics for the outdoors that offers the users a possibility to get in tune with nature All the fabrics that we use as the upholstery for our products are exclusive to Paola Lenti designed by us starting from the yarn and have played a key role in the company’s evolution two production activities coexist: one relates to fabrics and materials We reserve the same value for both production aspects From the experience we have gained in these nearly 30 years of activity we have understood that to design any environment it is necessary to have a common thought that makes the whole cohesive and credible are the greatest opportunities and challenges for design today Paola: I believe that every company today must seize the opportunity, if not feel the duty, to pay close attention to containing consumption, choosing non-polluting materials and processes and favouring local suppliers. They should aim for sustainability believing that beauty cannot and must not be separated from ethics One needs to be considerate about the circular economy a model we must all aim for if we want to live and produce ethically since our planet's resources are limited STIR: What is the biggest issue that the creative industry needs to fix Paola: I believe that the activity of a company must be seen today within the environmental and social context in which it operates The entrepreneur must act responsibly because his choices have significant effects on the territory an industrial activity that wants to address the issue concretely and consciously must take into account the entire life cycle of the product In the company that I manage together with my sister Anna we started thinking about eco-sustainable materials and products more than 10 years ago when it was not yet such a heartfelt topic STIR: What are some of the projects this year that you are most excited about Paola: On the occasion of the Milano Design Week we will introduce a new series called Jardín inspired by the collections created in the 1950s by the Cuban designer Clara Porset I discovered her works while leafing through a book where the furniture designed for the hotel Pierre Marqués in Acapulco was featured I immediately fell in love with the extraordinary linearity of the forms of the seating pieces that make the collection so actual even today We decided to pay homage to this designer with a strong personality by returning her works enhanced by modern technological aspects The whole operation was possible thanks to the precious collaboration of Professor Jorge A Vadillo López who founded and is still the curato of the Clara Porset Archive at CIDI Centro de Investigaciones de Diseño Industrial of UNAM Universidad Autónoma de México From capturing fleeting moments to uncovering universal truths the 2025 edition reveals the depth of visual storytelling across cultures A case of two cities—both bona fide global cultural capitals—reveals insights on precarity in the creative industries In its fifth collaboration with the luxury brand evokes the experience of "walking on a Parisian street with a focus on the power of the sun to imagine a sustainable future for humanity Exclusive preview for subscribers. Learn More Make your fridays matter. Learn More © Copyright 2019-2025 STIR Design Private Limited Please confirm your email address and we’ll send you a link to reset your password All your bookmarks will be available across all your devices Password must be 8 characters long including one capital letter By creating an account, you acknowledge and agree to the Terms of Use and Privacy Policy by STIR Select the Conversation Category you would like to watch Please enter your details and click submit Single account access for STIRworld.com,STIRpad.com and exclusive STIRfri content Verification link sent to check your inbox or spam folder to complete sign up process by STIRworld | Published on : May 11 The leading authority for the Architecture & Design community Recharge in a Restored Spanish Farmhouse in Menorca “Textiles and color have formed the basis of our work since the very beginning.” So states Paola Lenti of her namesake company Lenti studied graphic design at the Scuola Politecnica di Design in Milan and then went on to work as an art director for various fashion companies where she would create displays and environments making small glass and porcelain objects but switching to felt rugs which she says represented the true start of her self-named brand Materials research and sustainability have been guiding forces since day one. In 1997, she began working with designer Francesco Rota a collaboration that has produced some 70 collections and is still going strong It was 2000 when they turned their focus to outdoor aiming to create furnishings that are as attractive and comfortable as those for interiors That same year was when her younger sister Anna came on as managing director overseeing administrative and marketing aspects the company they’ve forged is synonymous with innovation but also with the handmade global but also local (except for a few items Paola Lenti products are all made in Italy) and unexpected texture and color combinations my entrepreneur father would take me along when he went to the countryside to paint and teach me to appreciate all the surrounding beauty Another childhood memory is receiving a book of colored collage paper and cutting up and combining the dark orange and dark turquoise pieces Each time I start selecting colors for a collection ID: How does color play through your col­lec­tions PL: We focus on it not only for individual fibers but also in the fabrics we weave from those fibers and for the collections and the ways they work together Even our solid fabrics often have more than one color of thread woven in finding increasingly better materials in terms of both ecological sustainability and durability ID: Which designers have you collaborated with ID: How long have you participated in that PL: Yes, Torno Subito at the W Dubai-The Palm hotel The chef is Massimo Bottura of the famous Osteria Francescana in Modena whereas the Dubai restaurant is playful and colorful recalling the joyful Italian Riviera of the 1960s PL: A designer friend of Bottura’s knew our brand and introduced him to our products Bottura liked them so much that he suggested using our pieces to the restaurant’s designer We ended up providing the furniture and choosing the colors The seating is from our existing collection but we custom-designed the square dining tables with tops of glazed lava stone ID: What’s coming up for the company PL: We are working with Adam Tihany on the MV Esmeralda cruise ship. We just completed work on 3.14 Plage we recently finished de­signing the interiors and exteriors of Living­space’s renovated and expanded furniture show­- room we’re always working on developing new materials—and improv­ing the ones we already use.  Keep scrolling to view more of Paola Lenti’s work >  > See more from the July 2019 issue of Interior Design  CWSA Announces Jean Lenti Ponsetto as Legacy Award Receipient6/28/2023 4:00:00 PM | ATHLETICS 2023) – The Collegiate Women Sports Awards (CWSA) honored longtime board members Jean Lenti Ponsetto Carolyn Schlie Femovich and Patty Viverito with the Dr Judie Holland Legacy Award this afternoon at the CWSA Celebration Luncheon hosted by Honda as announced by Chris Voelz Judie Holland Legacy Award is designed to recognize those who have played a significant role in the success of The Collegiate Women Sports Awards program This award is not necessarily an annual award but is given in the years when the most deserving person is identified This is the first presentation of the Legacy Award since its establishment in 2017 who served 37 years as the Executive Director Schlie Femovich and Viverito have served on the Executive Board of the CWSA for 16 years and were vital in the stabilization of the CWSA awards program during its transition to a non-profit entity leadership and talents the CWSA continues to celebrate the "best of the best" in collegiate women's athletics annually recognizing the accomplishments of female athletes in NCAA-member colleges "The CWSA was fortunate to have three great leaders on the Board and leading the Executive Committee at a crossroads in its history," stated Voelz skills and talents laced with passion for the organization they were able to stabilize the organization and put it in a position to thrive Carolyn and Patty be the first recipients of the Dr Judie Holland Award as their efforts have made an indelible mark on the Collegiate Women Sports Awards and we owe them our deep gratitude."  Lenti Ponsetto recently retired as one of the nation's most widely respected leaders in intercollegiate athletics and a driving force behind the unprecedented expansion and development of DePaul's athletics program Schlie Femovich is currently serving as Vice President of the PICTOR Group which she joined upon retirement from the Patriot League where she served as Executive Director for 16 successful years Throughout her tenure at the Patriot League she focused her efforts on the development and implementation of a comprehensive multimedia package expansion of League membership and improvement of the League's competitiveness Viverito is in her 37th year directing the Missouri Valley Football Conference as its commissioner She also spent the past 30 years as senior associate commissioner of the Missouri Valley Conference "I can't think of three more deserving persons or professionals than Jean Carolyn and Patty to receive this award for their contributions to CWSA," said Holland "They truly made a difference!"  honors the nation's top NCAA women athletes recognizing superior athletic skills academic excellence and eagerness to participate in community service Honda has provided more than $3.4 million in institutional grants to the universities of the award winners and nominees to support women's athletics programs at the institutions Judie Holland Legacy Award is named after the CWSA founder and leader in commemoration of Holland's 36 years of service and the program today includes a major presenting sponsor for the last 36 years and the following awards: The Honda Cup (signifying the Collegiate Woman Athlete of the Year) 12 sports awards for the best female athlete in each of the 12 NCAA-sanctioned sports Honda Inspiration Award and the Irv Grossman Award of Merit COVID-19 is a viral infectious disease whose main symptoms are respiratory neurological manifestations affect many COVID-19 patients These symptoms may include loss of taste and smell but also other more serious conditions such as acute encephalopathy whose pathophysiological mechanisms are not yet fully understood must be taken into account in the vaccine strategies currently in development researchers from the Institut Pasteur-Theravectys Joint Laboratory the efficacy of a lentiviral vector (LV)1 when used for primary vaccination by the muscular route This vaccine candidate not only induces in animals long lasting immunity based on neutralizing antibodies but also a strong durable cellular immunity linked to T-cells researchers from the Institut Pasteur-Theravectys Joint Laboratory have demonstrated the ability of the Lenti-S vaccine candidate to induce protection not only of the lungs but also of the central nervous system against SARS-CoV-2 infection In all animals immunized with the vaccine candidate viral replication is absent or largely reduced in the brain Immunization also eliminates the infection-mediated inflammatory phenomena in the brain The researchers established that the booster injection of Lenti-S by nasal route is necessary in the protection of the brain "Intranasal vaccination allows immune defenses to be directed straight into the upper respiratory tract and therefore act immediately at the site of entry of the virus into the body The protective capacity of the respiratory and nervous systems of Lenti-S extends with the same efficacy to the Gamma variant of SARS-CoV-2 as to the ancestral strain" explains Laleh Majlessi director of research at the Institut Pasteur-TheraVectys Joint Laboratory Beyond the induction of potent neutralizing antibodies the mechanism responsible for this broad spectrum of protection involves protective immunity based on T cells whose efficacy remains intact against the Gamma variant of the SARS-CoV-2 despite accumulated mutations in their Spike protein These data must now be confirmed in human clinical trials The lentiviral vector is devoid of all viral genes in order to be harmless to humans and produces the Spike protein is the key to entry of the virus into human cells.2.​ In the animal model used in this study expression of the human SARS-CoV-2 receptor (human ACE2) has been artificially induced in the organs including the brain to mimic the neurological effects of COVID-19 Brain Cross-Protection against SARS-CoV-2 Variants by a Lentiviral Vaccine in New Transgenic Mice, EMBO Molecular Medicine France2 Plate-Forme Centre d'Ingénierie Génétique Murine CIGM Institut Pasteur3 Experimental Neuropatholgy Unit Contribute Now Eponymous Italian furniture brand Paola Lenti can be spotted upon the decks of the most well-appointed yachts and vistas throughout Europe It’s no small wonder why the fashion-forward proprietors of BeDesign have dedicated the entire third floor of their luxurious Montrose furniture boutique to showcase the store's exclusive partnership with the prestigious indoor/outdoor brand they threw a party at BeDesign on Wednesday March 6 to showcase the brand and the comprehensive renovations to their building Celebrating 25 years of collaboration with Paola Lenti, designer Francesco Rota and CEO Anna Lenti traveled from Italy to join BeDesign for the unveiling of the new Linea for Outdoor line as well as the store's display of their wares Moderated by the always stylish Patty Dominguez, vice president of design and architecture for Cosentino invite-only crowd gathered for a charismatic conversation on all things Paola Lenti "Through the unveiling of our extraordinary third floor BeDesign brings to life its passion project – a rooftop paradise that envelops guests in the unmatched mastery of color and design by Paola Lenti," Dueñas said in a statement we have forged an interior design nirvana that sets a new standard The Paola Lenti experience here is our realized dream: vibrant This rooftop oasis stands as the crowning achievement of our endeavors." Anna Lenti and Francesco Rota.Photo by Johnny Than Rota and Lenti sat down with CultureMap to discuss the brand’s design concept and the question: Why has Paola Lenti found so much success in Houston When Francesco Rota met Paola Lenti 27 years ago they took a look at industrial-grade felts refining those to compressed felt textiles and created what Francesco refers to as “flying carpets,” colorful floor coverings that became an immediate success these pared-down new textiles have taken them on quite an adventure Francesco’s creative process for designing new pieces is beautiful in its simplicity The Linea chaise lounge is still as iconic twenty-five years later as it ever was which is the company’s companion outdoor piece Anna makes sure the i’s are dotted and the t’s are crossed back at Paola Lenti’s headquarters near Milan Realizing in 2003 that the outdoor furniture market remained limited to traditional materials Anna and Francesco wax poetic on those early days recalling how the only options for outdoor furniture were teak wood or stark As it did by using industrial felts for indoor furniture durable materials that could be retuned for outdoors with the retail market in mind; the answer: polypropylene meaning the brand was into sustainability long before it became a buzzword we asked if Paola Lenti's outdoor line can withstand a climate as diverse and extreme as Houston’s We investigated materials because we wanted a product to perform So metal had to be a certain kind of steel “The textile needs to be of a material that resists UV rays if you think about a yarn that makes textile Curious how the outdoor market has evolved in 25 years Anna explained that what clients are looking for now is different than what they wanted in the '90s it took awhile to convince customers to spend as much as $15,000-$18,000 for an outdoor sofa and between $5,000-$8,000 for each outdoor armchair which is what the pieces retail for at BeDesign people were not ready to spend and invest this amount of money for the outdoors because they weren’t used to having beautiful furniture outdoors,” she says “Year-by-year the market completely changed because people spend so much more time outdoors Now people want to have more continuity between their indoor and outdoor furniture.” chose Paola Lenti for two of the city’s most talked about new projects — Cocody Restaurant in River Oaks and The Thompson Hotel Paola Lenti is the best choice for ultra-premium outdoor furniture that holds up to Houston’s heat and humidity paying attention to the quality of materials: always looking for a point of contact “I fell in love with the colors and vibrancy of the brand ten years ago when I was introduced.” Find Paola Lenti at Cocody's patio.Photo by Mickael Zibi who has been known to spend a season or two taking up residence in The Raffles Hotel in Singapore once stated that she “cannot afford to buy cheap.” Alternatively Expertly mixed patterns play well together in this sunny living room « Back Scientist at the Institut Pasteur- TheraVectys Joint Laboratory have compared the immune responses of mice following a booster vaccination with either the candidate vaccine Lenti-COVID via nasal route or a third dose of messenger RNA vaccine via muscle route IgG antibody responses in the blood were amplified only Lenti-COVID administered intranasally induced major players of mucosal immunity in the airways : (i) mucosal anti-Spike igA Induction of these major players of mucosal immunity by the Lenti-COVID vaccine candidate leads to complete pulmonary protection against the Delta and the Omicron variants of SARS-CoV-2 demonstrating the suitability of the Lenti-COVID vaccine candidate as an intranasal booster against COVID-19 As the COVID-19 pandemic continues and the adaptive immunity initially induced by the currents COVID vaccines need to be reinforced the development of a vaccine that would block the transmission of the virus in the long term and maintain this capacity against various emerging variants appears relevant even if the SARS-CoV-2 virus become endemic a clinical phase will have to be initiated to confirm the safety and the effectiveness of this approach in humans The Seattle Times calls the music of John Lenti “a joy to behold,” while Gramphone praises Lenti’s playing of theorbo and baroque guitar for its “nuanced beauty and character.” He deploys his “uncommonly big sound” (Third Coast Digest) to acclaim as a soloist and chamber musician Join host John Floridis for his visit with John Lenti at the corner of Theorbo & Lute Central (Broadcast: "Musician's Spotlight,"  12/14/17 and 3/29/18. Listen on the radio Thursdays, 7:30 p.m., or via podcast.) Volunteer