Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates. Herein, we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional, in vivo imaging, and morphological techniques. SZV-1287 may have disease-modifying potential through analgesic, anti-inflammatory, and chondroprotective effects. The MIA mouse model is valuable for investigating OA-related mechanisms and testing compounds in mice at an optimal dose of 0.5 mg. Volume 15 - 2024 | https://doi.org/10.3389/fphar.2024.1377081 Introduction: Monoiodoacetate (MIA)-induced osteoarthritis (OA) is the most commonly used rodent model for testing anti-OA drug candidates we investigated the effects of our patented multitarget drug candidate SZV-1287 (3-(4,5-diphenyl-1,3-oxazol-2-yl) propanal oxime) that is currently under clinical development for neuropathic pain and characterized the mouse model through complex functional Methods: Knee OA was induced by intraarticular MIA injection (0.5 and 0.8 mg) Spontaneous pain was assessed based on weight distribution referred pain by paw mechanonociception (esthesiometry) neutrophil myeloperoxidase activity by luminescence vascular leakage and bone remodeling by fluorescence imaging histopathological alterations by semiquantitative scoring and glia activation by immunohistochemistry SZV-1287 (20 mg/kg/day) or its vehicle was injected intraperitoneally over a 21-day period Results: MIA induced remarkably decreased thresholds of weight bearing and paw withdrawal alterations in the tibial and femoral structures (reactive sclerosis histopathological damage (disorganized cartilage structure decreased matrix staining and tidemark integrity and increased synovial hyperplasia and osteophyte formation) and changes in the astrocyte and microglia density in the lumbar spinal cord There were no major differences between the two MIA doses in most outcome measures SZV-1287 inhibited MIA-induced weight bearing reduction Conclusion: SZV-1287 may have disease-modifying potential through analgesic The MIA mouse model is valuable for investigating OA-related mechanisms and testing compounds in mice at an optimal dose of 0.5 mg it is important to characterize the model through complex investigational techniques related to both inflammatory and nociceptive mechanisms we investigated the effects of our multitarget analgesic candidate SZV-1287 in the MIA-induced mouse OA model using integrated functional and morphological approaches Experiments were conducted on 8–16-week-old male C57BL/6J mice weighing 20–30 g All animals were bred and raised in the Laboratory Animal House of the Department of Pharmacology and Pharmacotherapy University of Pécs in cages of size 330 × 160 × 137 mm with a maximum occupancy of five mice per cage under 12-h light/dark cycles at 22°C ± 2°C and 50%–60% humidity The mice were provided with standard mouse chow (ssniff Spezialdiäten GmbH The total number of animals used in the experiments was 98 and they were randomized under the different experimental groups on the basis of the mechanonociceptive threshold of the hind paw according to the primary outcome of mechanical hyperalgesia The number of animals per group was determined on the basis of previously reported experiments with similar complex methodologies The animal study was conducted according to the European legislation (Directive 2010/63/EU) and Hungarian Government regulation (40/2013. 14.) regarding the protection of animals used for scientific purposes and was in full compliance with to the recommendations of the International Association for the Study of Pain The study was approved by the Animal Welfare Committee of the University of Pécs and National Scientific Ethical Committee on Animal Experimentation of Hungary as well as licensed by the Government Office of Baranya County (BA02/2000–52/2018) The right hind limbs of the mice were shaved, and ketamine (120 mg/kg) and xylazine (6 mg/kg) were administered intraperitoneally (i.p.) as anesthesia; then, 20 µL of sodium MIA solution (0.5 or 0.8 mg dissolved in saline to observe potential dose-dependent changes) was injected into the knee joint space through the patellar ligament to induce experimental OA (Horvath et al., 2016; Tékus et al., 2018) Saline at the same volume was injected into the control animals Kolliphor HS 15 was heated moderately to 30°C and added to SZV-1287; the solution was then sonicated to maximize the solubility of SZV-1287 before adding distilled water (2 mg/mL) and vortexing All solutions used in this study were always freshly prepared before injection Treatment protocols of all groups of animals involved in the study 0.5 or 0.8 mg) was injected intraarticularly (i.a.) into the right knee joints of the osteoarthritic (OA) animals on day 0 Non-OA control animals received saline using the same protocol with the vehicle (0.1 mL/10 g body weight) with the same volume of SZV-1287 (20 mg/kg) At the end of the first two experiments (on day 21) the mice were euthanized with sodium pentobarbital (100 mg/kg followed by micro-computed tomography (micro-CT) analysis and harvesting of the knee joints for histopathological evaluations At the end of the third experiment (on day 21) the animals were deeply anesthetized using sodium pentobarbital (70 mg/kg i.p.) for bone remodeling measurements and were transcardially perfused with phosphate-buffered saline (PBS) followed by 4% paraformaldehyde The brains and spinal cords of the animals were then removed for immunohistochemical evaluation of the astrocytes and microglia activation Flowchart describing the experimental design and data analyses were performed in a blinded manner and the animals were coded throughout the experiments The codes were revealed only after the principal investigator completed all the evaluations (Á.I.H) Each experimental group was represented in all studies to minimize the risk of confounding factors Each investigational technique and treatment were performed by the same researcher/technician throughout the study Weight distribution decrease on the hind limbs as an indicator of spontaneous pain was assessed using an advanced dynamic weight bearing apparatus (Bioseb, Vitrolles, France) (Tékus et al., 2018) The mice were placed in a perspex chamber with a pressure-sensitive floor and were allowed to move freely The weights borne on the hind limbs (measured in grams) were tracked and recorded over a 5-min period weight bearing was calculated as the ratio of weight borne on one hind limb and the total weight borne by the hind limbs (i.e. [weight borne on the ipsilateral or contralateral hind limb/(weight borne on the ipsilateral hind limb + weight borne on the contralateral hind limb)] × 100) Paw withdrawal threshold decrease (mechanical hyperalgesia) was assessed as an indicator of referred pain through dynamic plantar esthesiometry (Ugo Basile, Gemonio, Italy) (Horvath et al., 2016) Mice were placed in plexiglass boxes with metal mesh floors so that they could move freely the plantar surfaces of the hind paws were touched using a straight metal filament with a lifting force of 2.5 g/s until the mice retracted their paws (with the cutoff value being 10 g) The mean of three measurements was recorded as the withdrawal threshold from both hind paws and was expressed in grams The percentage change of the withdrawal threshold was calculated for comparison with the mean initial baseline value The knee diameters were measured with a digital caliper (OWIM GmbH and Co. KG, Neckarsulm, Germany) (Horvath et al., 2016). Each mouse was stably handled by one investigator, while another person extended one of the hind limbs to measure the knee joint thickness (expressed in millimeters) in both the anteroposterior and mediolateral directions (Botz et al., 2013) Neutrophil MPO activity, MMP activity, vascular leakage, and bone remodeling in the knee joint were determined using the IVIS® Lumina III in vivo imaging system (PerkinElmer, Waltham, MA, USA) (Horváth et al., 2018) hair was removed from both hind limbs through shaving and application of Veet® cream in ketamine (120 mg/kg i.p.) anesthesia to prevent scattering/absorption of the light signal Neutrophil MPO activity was measured using luminol (5-amino-2,3-dihydro-1,4-phthalazine-dione) sodium salt injection (150 mg/kg i.p.) dissolved in saline (30 mg/mL); MMP activity was measured by an activatable fluorescent probe for MMP-2 and -13 (MMPSense 750 FAST; 2 nmol/subject i.v.); vascular leakage was measured with the vascular fluorescent probe AngioSense 750 EX (2 nmol/subject and bone remodeling was measured using the targeted fluorescent probe OsteoSense 680 EX (2 nmol/subject Injections of the probes and measurements were performed under ketamine (120 mg/kg Bioluminescence imaging was performed 10 min after injection (120 s acquisition and fluorescent imaging was performed 24 h post injection (auto acquisition time excitation/emission filters: 740/790 nm for MMP activity and vascular leakage or 680/845 nm for bone remodeling) Using Living Image® software (PerkinElmer USA) identical regions of interest (ROIs) were applied around the knee joints and luminescence was expressed as the total radiance (total photon flux/s) while fluorescence was expressed as the total radiant efficiency ([photons/s/cm2/sr]/[µW/cm2]) within the ROI Bone morphology in the knee joint was assessed through the SkyScan 1,176 in vivo micro-CT (Bruker, Kontich, Belgium) (Tékus et al., 2018) On the last day of the experiment (day 21) the mice were anesthetized using sodium pentobarbital (70 mg/kg and the periarticular regions of the tibia and femur were repeatedly scanned with a voxel size of 17.5 μm and the bone structures were assessed using the CT Analyser® software Standardized ROIs were drawn around the entire epiphysis of the distal femur or proximal tibia from which bone volume density (bone volume/total volume) and open porosity (Po(op)) were quantified and matrix staining were assessed through the modified Mankin score on scales of 0–6 synovial hyperplasia and inflammatory cell infiltration (0–3) as well as osteophyte formation (0–1) were scored The scores for the six criteria were accumulated to generate a composite score with values ranging from 0 to 18 the mice were deeply anesthetized with sodium pentobarbital (70 mg/kg i.p.) and transcardially perfused with PBS followed by 4% paraformaldehyde The brains as well as the L3–L6 spinal cord segments innervating both the knee joints and hind paws were removed and post-fixed for 4 h in the same fixative before transferring into a medium containing 30% sucrose dissolved in 0.1 M PBS at 4°C until they sank for cryoprotection (at least overnight) Free floating sections (30 µm) were prepared on a freezing microtome (Leica Biosystems Germany) and stored at −20°C in antifreeze solution until further processing GFAP and Iba1 labeling were used in the SC, PAG, and SSC to visualize the astrocytes (Eng et al., 2000) and activated microglia (Ito et al., 1998) free-floating serial SC sections were washed in 0.05% TRIS-buffered saline (TBS pH: 7.6) before treating with methanol and 3% H2O2 for 30 min; the PAG and SSC sections were washed in 0.1 M PBS and treated with only 3% H2O2 for 30 min the SC sections were thoroughly washed in TBS while the PAG and SSC sections were washed in PBS; then non-specific binding was prevented by incubating the sections for 1 h in 3% bovine serum albumin (BSA) in TBS containing 0.5% Triton X-100 (for SC) or in 3% normal goat serum (NGS) in PBS containing 0.5% Triton X-100 (for PAG and SSC) the SC sections were repeatedly rinsed in TBS while the PAG and SSC sections were rinsed in PBS for 1 h before incubation for one night at 4°C with a monoclonal mouse anti-GFAP antibody (1:5,000) or with a polyclonal rabbit anti-Iba1 antibody (1:10,000) the sections were incubated with anti-rabbit or anti-mouse biotinylated secondary antibodies (1:200) for 2 h before being washed and incubated in avidin-biotin-horseradish peroxidase (1:100 for SC or 1:200 for PAG and SSC) for 2 h The labeled cells were visualized in 0.025% of 3,30-diaminobenzidine and 0.01% of H2O2 in TBS (for SC) or in PBS (for PAG and SSC) for 3 min The slides were coded before quantification to ensure objectivity The images were acquired on a Nikon Eclipse Ti-U workstation All of the immunolabeled cells were counted manually A single experimenter who was blinded to the group identification of each animal performed the data collection The code was not broken until the cell counting analyses were completed All the labeled astrocytes and microglial cells were counted within the borders using an objective of ×10 or ×20 magnification The numbers of GFAP and Iba1 immunopositive cells were counted in the areas of interest and expressed as number of cells per mm2 the averages of 2–4 sections of 30 µm thickness were used from each of the animals Ketamine (Calypsol®) was purchased from Gedeon Richter Plc Hungary); xylazine (Sedaxylan®) was obtained from Eurovet Animal Health B.V and 3,30-diaminobenzidine were sourced from Sigma-Aldrich (St USA); sodium pentobarbital (Euthanimal®) was procured from Alfasan Nederland B.V Netherlands); Veet® cream was acquired from Reckitt (Slough United Kingdom); luminol sodium salt was purchased from Gold Biotechnology (Olivette and OsteoSense 680 EX were from PerkinElmer (Waltham anti-rabbit and anti-mouse biotinylated secondary antibodies and avidin-biotin-horseradish peroxidase (Vectastain Elite ABC Kit) were supplied by Vector Laboratories (Newark USA); monoclonal mouse anti-GFAP antibody was sourced from Cell Signaling Technology (Danvers RRID: AB_561049); and polyclonal rabbit anti-Iba1 antibody was obtained from FUJIFILM Wako Chemicals Europe GmbH (Neuss Effects of SZV-1287 on MIA-induced weight bearing asymmetry and mechanical hyperalgesia Dynamic weight-bearing and percentage changes of the withdrawal thresholds of the ipsilateral hind limbs of the (A,C) 0.5- and (B,D) 0.8-mg MIA-injected SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) mice compared to the respective vehicle-treated groups The data are shown as means with 95% CI of n = 7–29 mice/group G indicates the effect size calculated by Hedges’ g The lack of an inhibitory effect on day 21 is likely owing to the more robust cartilage destruction in response to the higher MIA dose causing increased production of inflammatory mediators and tissue injury which could be less sensitive to the inhibitory abilities of 20 mg/kg dose of SZV-1287 Effects of SZV-1287 on MIA-induced histopathological alterations (A) Semiquantitative scoring of the histopathological alterations in the contralateral and ipsilateral knee joints of SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) MIA-injected mice compared to the vehicle-treated groups on day 22 and (B–F) representative slides of the ipsilateral knee joints stained with Safranin O (× 10 magnification) White arrows show the most characteristic MIA-induced histopathological alterations of the cartilage layer Box plots represent medians of the composite scores for n = 6–15 mice/group In vivo imaging was performed only for the 0.5 mg MIA group to obtain information on the inflammatory molecular mechanisms and microarchitectural changes since no differences were observed in any of the functional and morphological parameters between the two doses 30% mortality occurred in the case of the group receiving 0.8 mg of MIA Effects of SZV-1287 on MIA-induced neutrophil myeloperoxidase (MPO) and matrix metalloproteinase (MMP) activity increases Representative images and quantitative analyses of the (A) neutrophil MPO and (B) MMP activities in the ipsilateral knee joints of SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) 0.5-mg MIA-injected mice compared to the vehicle-treated group after 3 and 24 h as well as 4 and 18 days after osteoarthritis induction The data are shown as means with 95% CI of n = 6–12 mice/group in the case of neutrophil MPO activity and n = 5–6 mice/group in the case of MMP activity Effects of SZV-1287 on MIA-induced vascular leakage and bone remodeling Representative images and quantitative analyses of (A) vascular leakage and (B) bone remodeling in the ipsilateral knee joints of the SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) 0.5-mg MIA-injected mice compared to the vehicle-treated group 7 days and 22 days after osteoarthritis induction The data are shown as means with 95% CI of n = 5–6 mice/group in the case of vascular leakage and n = 3–8 mice/group in the case of bone remodeling Effects of SZV-1287 on MIA-induced microarchitectural changes of the distal femur Quantifications of (A) bone volume density and (F) open porosity (Po(op)) in contralateral and ipsilateral femoral epiphyses of the SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) 0.5-mg MIA-injected mice compared to the vehicle-treated group on day 22 (G) Representative 3D reconstructions of the contralateral and ipsilateral knee joints and (H) axial CT slices demonstrating cortical bone loss and osteophyte formation (cortical irregularities and osteophytes highlighted by arrowheads) The data are shown as means with 95% CI of n = 8–10 mice/group Effect of SZV-1287 on MIA-induced astrocyte density increase in the lumbar region of the spinal dorsal horn (A) Quantitative analysis and (B) representative images of the astrocyte marker glial fibrillary acidic protein (GFAP) immunoreactivity (× 10 magnification) in the contralateral and ipsilateral L3–L6 spinal dorsal horn of the SZV-1287-treated (20 mg/kg i.p Data are shown as means with 95% CI of n = 5–8 mice/group Effect of SZV-1287 on MIA-induced microglia density increase in the lumbar region of the spinal dorsal horn (A) Quantitative analyses and (B) representative images of the microglia marker ionized calcium-binding adaptor molecule 1 (Iba1) immunoreactivity (× 10 magnification) in the contralateral and ipsilateral L3–L6 spinal dorsal horn of the SZV-1287-treated (20 mg/kg i.p The data are shown as means with 95% CI of n = 5–7 mice/group We show here that our multitarget analgesic candidate SZV-1287 inhibits both spontaneous and referred pain-related behaviors as well as some inflammatory parameters and tissue damage in the MIA-induced mouse OA model indicating potential disease-modifying effects The SZV-1287-induced analgesic effects were observed in the late stage of the model presumably via decreased central nociceptive processing and sensitization we provide integrative characterization of the MIA model with complex functional and in vivo imaging analyses related to both inflammatory and nociceptive mechanisms which is in agreement with the findings of our mouse model All of these data suggest the important roles of ROS production and inflammatory vascular changes in the initiation of OA our unique and innovative multitarget analgesic candidate SZV-1287 could become a promising novel therapy for OA with special emphasis on pain while also exerting anti-inflammatory and chondroprotective effects Exploration of its disease-modifying effects and mechanisms is planned in the future in surgically induced OA models to induce less robust cartilage degeneration The original contributions presented in the study are included in the article/Supplementary Material; further inquiries can be directed to the corresponding author The animal study was approved by the Animal Welfare Committee of the University of Pécs and National Scientific Ethical Committee on Animal Experimentation of Hungary The study was conducted in accordance with all local legislations and institutional requirements KB: methodology and writing–review and editing NS: investigation and writing–review and editing EB: investigation and writing–review and editing VT: methodology and writing–review and editing BB: investigation and writing–review and editing KR: investigation and writing–review and editing AF: investigation and writing–review and editing BC: methodology and writing–review and editing PM: conceptualization and writing–review and editing The authors declare that financial support was received for the research The research infrastructure was supported by grants from the European Regional Development Fund (GINOP-2.2.1-15-2016-00020); Ministry for Innovation and Technology from the Source of the National Research financed under the EGA 16 funding scheme (TKP2021-EGA-16); National Research Development and Innovation Office (OTKA K 138046 and NKFIH FK 146283); National Recovery Fund (RRF-2.3.1-21-2022-00015 National Laboratory for Drug Research and Development (PharmaLab) with support from the European Union); National Brain Research Program 3.0; and the Hungarian Research Network ÁH was supported by the ÚNKP-22-4 New National Excellence Program of the Ministry for Culture and Innovation from the Source of the National Research which has been implemented with the support provided by the Recovery and Resilience Facility (RRF) financed under the National Recovery Fund budget estimate The authors are grateful to Dóra Ömböli and Lilla Draskóczi for their professional technical assistance with the animal experiments Anikó Perkecz for her expert help with histological processing Ildikó Fábián for preparing the free-floating brain and spinal cord sections Barbara Fülöp for assisting with the immunohistochemical evaluations and Tamás Kiss for performing the micro-CT measurements (all persons are from the Department of Pharmacology and Pharmacotherapy The authors also acknowledge Tamás Kálai and Cecília Sár (Institute of Organic and Medical Chemistry This research was performed in collaboration with the Histology and Light Microscopy Core Facility at the Szentágothai Research Centre of the University of Pécs Author ZH is a founder and shareholder of PharmInVivo Ltd This has no scientific or commercial conflict of interest with the current work The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphar.2024.1377081/full#supplementary-material SUPPLEMENTARY FIGURE S1 | Comparison of the weight bearing asymmetry and mechanical hyperalgesia effects in the 0.5- and 0.8-mg MIA-induced groups Dynamic weight bearing of the ipsilateral hind limbs of the vehicle- and SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) saline and 0.8-mg MIA-injected mice (A) compared to the baseline (BL) and (B-F) contralateral hind limbs Percentage changes in the withdrawal thresholds of the (G) ipsilateral and (H) contralateral hind paws of the vehicle-treated mice administered saline or 0.5 and 0.8 mg MIA The data are shown as means with 95% CI of n = 9–29 mice/group SUPPLEMENTARY FIGURE S2 | Effects of SZV-1287 on MIA-induced knee edema Percentage changes in the anteroposterior (AP) and mediolateral (ML) knee diameters of the vehicle- and SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) mice administered (A) 0.5 and (B) 0.8 mg MIA as compared to the respective saline-injected group SUPPLEMENTARY FIGURE S3 | Effects of SZV-1287 on MIA-induced microarchitectural changes of the proximal tibia Quantifications of the (A) bone volume density and (F) open porosity (Po(op)) in the contralateral and ipsilateral femoral epiphyses of the SZV-1287-treated (20 mg/kg i.p every day during the 21-day experimental period) 0.5 mg MIA-injected mice compared to the vehicle-treated group on day 22 Emerging therapeutic agents in osteoarthritis PubMed Abstract | CrossRef Full Text | Google Scholar Nociceptive phenotype alterations of dorsal root ganglia neurons innervating the subchondral bone in osteoarthritic rat knee joints PubMed Abstract | CrossRef Full Text | Google Scholar OARSI guidelines for the non-surgical management of knee PubMed Abstract | CrossRef Full Text | Google Scholar Pros and cons of mouse 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There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page The performance company’s 49th Season of the Holiday Classic receives rave reviews The longest-running NUTCRACKER production in SoCal returned for a 10 day run Nov 4  to The Eli & Edythe Broad Stage in Santa Monica The second weekend was completely sold out for Westside Ballet of Santa Monica’s 9th year running at the Santa Monica College Performing Arts Center.   The cast of over 85 student dancers included three professional guest artists who shared the stage in the nonprofit performance company’s 49th Nutcracker Season Students travel to Santa Monica all the way from Oxnard and Calabasas in the North—and Hollywood Hills Beverly Hills and Mid City in the East—many times a week posted a Facebook review echoing many audience goers reactions: “I have seen Nutcracker productions EVERYWHERE and FOREVER … THIS Broad Theater / Westside Ballet of Santa Monica WAS THE BEST PERFORMANCE I have ever seen It was a traditional story with the most exquisite dancing and beautiful feelings from the cast That’s how good and perfect it all was The company was met with standing ovations and loud cheers for many acts—especially the acrobatic leaps of Westside School of Ballet’s Boys Division elite dancers who performed a Russian dance that features high jumps and ballet technique re-choreographed by Associate Executive Director Adrian Blake Mitchell (Mikhailovsky Theatre).   Sawyer and Dylan each performed as the lead Sugar Plum Cavalier in the “Nutcracker Suite,” which Westside performs for 1,000 elementary school students in the Santa Monica-Malibu and Los Angeles Unified School districts The ballet was narrated to ballet excerpts Evan Hull joined Dylan in performing the iconic Toy Soldier Sawyer and Dylan also brought their prowess to the Battle scene in the Nutcracker and Mouse King’s duel Evan travels all the way from Porter Ranch nearly every day for rehearsals and classes.  The dancers were all professional and never missed timing I hope to hear more about the programs and dates The Los Angeles community has been celebrating the holidays with Westside Ballet’s rendition of the classic since 1973 or the role of Center Spanish at New York City Ballet classical ballet based on the story of “The Nutcracker and the Mouse King” by E.T.A Hoffmann and the Marius Petipa version.  The Westside production featured 225 costumes and four elaborately designed scenes all of which had been updated with new backdrops and accouterments over the years while retaining the most beloved traditional characters and iconic moments and snow falling over a stunning corps de ballet Guest Principals Along with Hungarian born dancer & choreographer Maté Szentes professional dancers Jack Virga Hall and Evan Swenson performed alongside the Westside Ballet pre-professional performers Szentes performed the lead role of the Sugar Plum Fairy’s Cavalier Szentes started training at age 6 and attended the Hungarian Dance Academy as well as North Carolina Dance he spent three years dancing both corps de ballet and soloist roles with the Hungarian National Ballet He moved to California in 2012 to dance with the Sacramento Ballet He is a regular principal dancer with American Contemporary Ballet who has been a resident guest artist at Westside Ballet for the past decade performed the lead role of the Cavalier for the Snow Queen and the Arabian pas de deux was granted a full scholarship to attend the Houston Ballet Academy when he was just 17 years old he was a soloist and principal dancer with Atlanta Ballet.  Hall is a Los Angeles-based dance instructor who is also certified by the American Ballet Theatre He is currently on tour with the modern company at Lula Washington Dance Theatre the contemporary company at Pony Box Dance Theatre and the classical ballet all-male pointe company at Ballet D’ Hommes Community Outreach Preview PerformanceOn Friday Westside Ballet hosted a free preview performance for members of the local community and charitable organizations including the Santa Monica Police Activities League and the Boys & Girls Clubs of Santa Monica and West Los Angeles Past ProductionsMany professional dancers have made their stage debuts in the Westside Ballet of Santa Monica’s Nutcracker over the past five decades ABT); Anna Liceica (ABT); Joy Womack (Bolshoi Ballet Kremlin Ballet Theater); Martine Harley (Houston Ballet); Melissa Barak (NYCB Barak Ballet); Andrew Veyette and Samuel Melnikov (NYCB) Among the newest are: Adrian Blake Mitchell (Mikhailovsky Theatre); Shelby Tzung (National Ballet of Canada); Lucia Connolly (Joffrey Ballet); Molly Novak (Semperoper Ballett Boston Ballet); Severina Wong (Ballet West); Giorgia Martelloni-Zabriskie (Dance Theater of Harlem); Sarah Hurty (Ballet Omaha); and Lyrica Brielle Blankfein Woodruff (Broadway’s Anastasia).  Sponsors for the NutcrackerThe Nutcracker production was made possible in part by grants from the City of Santa Monica—with past grants from the Rotary Club and a LA County COVID-19 Arts Relief Fund—and from sponsorships from local Santa Monica individuals and organizations such as Santa Monica College Public Policy Institute Nutcracker Dancers Receive College Credit for PerformingUnder an education initiative launched in 2013 Westside’s dancers who are high school students concurrently enrolled in Santa Monica College dance course 59A will receive credit for the performances The credits are transferable to any of California’s public four-year colleges and universities About Westside Ballet of Santa Monica – One of the nation’s premier pre-professional ballet training companies the nonprofit organization’s mission is to give promising young dancers the performance opportunities so important to their development––as well as make dance more accessible to local children and families Westside Ballet of Santa Monica was created by Yvonne Mounsey (New York City Ballet) and Rosemary Valaire (Royal Ballet) in 1973 Westside Alumna Martine Harley (Houston Ballet) took over as Artistic Director in 2013 the company comprises approximately 80 dancers distinguishes itself as a non-audition academy where all are welcome to study ballet and train to the most refined pre-professional level Nearly all the artistic staff are products of the school bringing a consistent approach to classical ballet training six years before the founding of the performance company and produced many of classical ballet’s luminary performers known worldwide For more information, visit www.westsideballet.com Civil Rights Groups Say Law Enforcement Violated Students’ Rights Civil rights attorneys representing demonstrators at UCLA have filed a federal.. 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Subscribe to our newsletter to receive the latest news and events in Los Angeles and the surrounding areas Made with ❤️ by ENKI Tech It was a magic moment as Anita Szentes floated over the crowd in Hertz Arena her tiny frame held aloft by a bouquet of balloons the aggregate size of a bounce house The opening night audience for Cirque du Soleil's "Corteo" on Wednesday must have looked like baby birds below offering French impressions of her bubble-buttressed view In an evening packed with Olympic-quality feats costuming tone to its dreamlike narrative and its eclectic original score the overhead sequence pulled the audience into the act To keep Anita sailing, members of the audience had to create landing pads on their palms and propel her up and forward.  It's not that we didn't get ample chances to respond to the entreaties of its central character As he belts an oversized inflated soccer ball around the stage he tells the audience that he's playing for his team during which Mauro jousts with an extremely fluid human marionette (Joseane Martins Costa) and one of the overhead angels who make intermittent appearances "Corteo" is the re-enactment of Mauro's dream of his own clown funeral but until now it has only toured in a tent version Hertz Arena is one of the early arena venues for it True to Cirque's foundations as a street performer circus show in its visual feast, you sometimes fear you're overindulging in the desserts You find your eyes chasing the little Tour Eiffel robots on wheels that coo at Roman Munin instead of watching him navigate an untethered ladder clambering up it forward and backward and rolling from one side to another balanced in midair There's incredible physical talent in both balance and muscle that should command rapt attention but it sometimes gets stiff competition from costumes and props four females meant to symbolize the main character's former loves contort themselves and fly from the pearl ropes of chandeliers that are as eye-catching as they are.  the show shoots ideas and characters like bullets and it makes a fast-paced evening at Hertz Arena The gasp-inducing moments include a pair of performers flying from one performer's arms and crossing in mid-air to land in another's.  Four men do back flips with twists from a teeterboard that evoke Olympic ski jump competition — but these men have made their own momentum, leaping skyward until the height is right. Aurélie Deroux Dauphin executes fabric twist figures from fabric wrapped around her feet and waist The original score comes from Philippe Leduc and Maria Bonzanigo New Orleans jazz and even a bit of klezmer to accompany Mauro's story envisioning his own feather-winged future.  We have to echo the sentiments of another reviewer: If this is the afterlife Where: Hertz Arena, 11000 Everblades Parkway Tickets: $49 to $130; parking in the arena lot is $20 To buy: Ticketmaster online or at the box office of Hertz Arena Something else: Park in the adjacent Miromar center lots for free access by walking across the west drive at two hours and 45 minutes including the intermission may not be for young children; gauge your child's tolerance for late hours and long periods of being seated when you're considering purchasing This work, U.S. civil affairs, NATO CIMIC units collaborate during U.S. Army Europe summer exercises, by Doug Magill, identified by DVIDS, must comply with the restrictions shown on https://www.dvidshub.net/about/copyright normally a fierce critic of the Orbán administration who rarely gives any gestures of kindness to his host country visited the town of Szentes in South-Eastern Hungary where Hungarian and American special operation forces took part in joint exercises on Wednesday The US Embassy in Budapest shared an image of the occasion with Ambassador Pressman standing between soldiers holding up the Hungarian and the American flags Hungary benefits from cutting edge defense equipment and expertise The Alliance makes Hungary safer than it has ever been Sweden’s accession to NATO will make the Alliance stronger than it has ever been As per the press release issued by the Embassy ‘Allies’ commitment to Article 5—the concept that an attack on one is an attack on all—makes Hungarians the safest they have ever been in history Sweden’s accession to NATO is a key priority for every one of Hungary’s Allies It is time to welcome them into the Alliance as its 32nd member making Hungary and all of its Allies stronger and safer.’ the Ambassador witnessed a fire exercise; as well as a demonstration on how to operate special US-built riverine boats The special watercraft are now in the possession of the Hungarian Defence Forces ‘The United States is the world leader in defense technology Hungary’s membership in NATO brings with it access to cutting edge equipment and expertise,’ the ambassador remarked about the American equipment The rare show of positivity likely came in anticipation of the vote in the Hungarian parliament on the following Monday where the National Assembly was expected to ratify Sweden’s accession into NATO thus making it the 32nd nation in the military alliance US politicians have been pressuring Hungary to move faster in approving Sweden’s NATO membership Ambassador Pressman and many of his fellow ambassadors of other NATO nations attended the special parliamentary session on 5 February where a vote on the Swedish accession had already taken place not enough Members of Parliament attended to make the vote legally binding yielded the expected result—the National Assembly of Hungary voted in favour of Swedish NATO accession thus officially making it the alliance’s 32nd member state Hungarian Conservative is a quarterly magazine on contemporary political philosophical and cultural issues from a conservative perspective Thanks for visiting ! The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy. We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here. The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development. Recent studies have indicated the role of these chemokines also in cardiovascular diseases. We aimed to present current knowledge regarding the role of CXCR3-binding chemokines in the pathogenesis of atherosclerosis and during acute myocardial infarction. Cytokines and Soluble Mediators in Immunity Volume 9 - 2018 | https://doi.org/10.3389/fimmu.2018.01932 This article is part of the Research TopicCardioimmunology: Inflammation and Immunity in Cardiovascular DiseaseView all 22 articles The chemokine receptor CXCR3 and associated CXC chemokines have been extensively investigated in several inflammatory and autoimmune diseases as well as in tumor development Recent studies have indicated the role of these chemokines also in cardiovascular diseases We aimed to present current knowledge regarding the role of CXCR3-binding chemokines in the pathogenesis of atherosclerosis and during acute myocardial infarction Development and progression of the atherosclerotic lesion The present review focuses on the role of the IFN-γ inducible chemokines and their receptor CXCR3 in the development of atherosclerosis and consequent coronary artery disease. Possible clinical implications of the presented findings are not entirely clear, but the currently available clinical studies suggest that this might be a promising area of intervention in the future of cardiovascular therapy and prevention (13) Biased signaling on CXCR3 results in different effect of its ligands during inflammatory events. It seems that CXCL9 and CXCL10 promote inflammation through inducing T cell polarization into Th1/Th17 cells, while CXCL11 drives the development of regulatory T cells (Treg) cells which play a role in restraining inflammation (22) CXCR3 may be hypothesized to play a dual role by mediating both proinflammatory and anti-inflammatory pathways Other anti-inflammatory molecules known for their protective effect in cardiovascular diseases were found to influence T cell trafficking through the chemokine system. Adiponectin was shown to inhibit CXCR3 ligand production in macrophages, while heparin competes for binding with CXCL9, CXCL10, and CXCL11 on endothelial cells (30, 31) the role of CXCL9 and CXCL11 in infarct healing is not known Clinical studies with CXCR3 binding chemokines in coronary artery disease In a large case-control study of 312 patients with coronary heart disease and 472 controls, a significant association of increased serum CXCL10 was found with the risk of coronary heart disease. Higher CXCL10 levels were also found to be independently correlated with established laboratory risk markers of coronary heart disease such as acute-phase proteins and inflammatory cytokines (50) CXCL8, CXCL10, and CXCL16 were found to be correlated with maximum troponin T levels, infarct size and impaired myocardial function assessed by cardiac magnetic resonance in patients after successful PCI (57). Serum CXCL10 level before PCI also proved to be an independent predictor of cumulative CK release and was negatively correlated with infarct size, as indicated by peak CK and CK-MB enzymes (58) CXCR3 binding chemokines might be promising biomarkers for the risk assessment of coronary heart disease. Chemokine levels however have a short half-life and may have high intraindividual variability; (52) this results in difficulties in estimating the best sampling time and may generate conflicting clinical results CXCL10 is the most extensively studied of the three chemokines in the clinical setting of ischemic heart disease; less is known about the role of CXCL9 and CXCL11 New clinical studies are needed to fill in the gaps and properly map the role of alterations in chemokine levels in coronary artery disease and during acute coronary events All authors listed have made a substantial direct and intellectual contribution to the work This work was supported by a grant from the National Research Development and Innovation Fund of Hungary (K120536) The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest atherosclerosis and coronary artery disease Pathophysiology of acute coronary syndrome Lymphocyte migration into atherosclerotic plaque CXCL4-induced macrophages in human atherosclerosis Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells chemokines and chemokine receptors in patients with coronary artery disease Increased Th1 activity in patients with coronary artery disease The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions Platelets and their chemokines in atherosclerosis—clinical applications CXC chemokine receptor 3 alternative splice variants selectively activate different signaling pathways Overview of the mechanisms that may contribute to the non-redundant activities of interferon-inducible cxc chemokine receptor 3 ligands update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors NMR structure of CXCR3 binding chemokine CXCL11 (ITAC) Interferon–inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3 Intracellular domains of CXCR3 that mediate CXCL9 Role of chemokine receptors CXCR4 and CXCR7 for platelet function I-TAC/CXCL11 is a natural antagonist for CCR5 Biased signaling pathways via CXCR3 control the development and function of CD4+ T cell subsets Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivo CXCR3 antagonist NBI-74330 attenuates atherosclerotic plaque formation in LDL receptor –deficient mice Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells Atherosclerotic plaque stability is affected by the chemokine CXCL10 in both mice and humans Elevated concentration of interferon-inducible protein of 10 kD (IP-10) is associated with coronary atherosclerosis Platelet factor 4 localization in carotid atherosclerotic plaques: correlation with clinical parameters CD4+ T cells in atherosclerosis: regulation by platelets Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis Heparin displaces interferon-γ-inducible chemokines (IP-10 and Mig) sequestered in the vasculature and inhibits the transendothelial migration and arterial recruitment of T cells Development of murine ischemic cardiomyopathy is associated with a transient inflammatory reaction and depends on reactive oxygen species Induction of the CXC chemokine interferon-γ-inducible protein (IP)-10 regulates the reparative response following myocardial infarction Interleukin-1 induces pro-inflammatory leukocyte infiltration and regulates fibroblast phenotype in the infarcted myocardium Platelet factor 4 differentially modulates CD4+ CD25+ (regulatory) versus CD4+ CD25- (nonregulatory) T cells Cellular recruitment in myocardial ischaemia/reperfusion injury Expression of stromal cell-derived factor-1 receptors CXCR4 and CXCR7 on circulating platelets of patients with acute coronary syndrome and association with left ventricular functional recovery Targeting inflammatory pathways in myocardial infarction Regulation of the inflammatory response in cardiac repair Plasma levels of the monocyte chemotactic and activating factor/monocyte chemotactic protein-1 are elevated in patients with acute myocardial infarction PubMed Abstract | Google Scholar CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12 Chemokines: immunology's high impact factors CXCR3 internalization following T cell-endothelial cell contact: preferential role of IFN-inducible T cell α chemoattractant (CXCL11) Chemokines: a new classification review system and their role in immunity CrossRef Full Text | Google Scholar The CXCL10/CXCR3 axis and cardiac inflammation: implications for immunotherapy to treat infectious and noninfectious diseases of the heart The chemokine system: novel broad-spectrum therapeutic targets Role of I-TAC-binding receptors CXCR3 and CXCR7 in proliferation activation of intracellular signaling pathways and migration of various tumor cell lines Circulating chemokines accurately identify individuals with clinically significant atherosclerotic heart disease and correlation with established cardiovascular risk markers Higher circulating levels of chemokines CXCL10 CCL20 and CCL22 in patients with ischemic heart disease and ischemic stroke events: the PRIME study Chemokines and incident coronary heart disease results from the MONICA/KORA augsburg case-cohort study Clinically significant novel biomarkers for prediction of first ever myocardial infarction the tromsø study Serum CXCL10 and CXCL12 chemokine levels are associated with the severity of coronary artery disease and coronary artery occlusion CXCR3 chemokine receptor–plasma IP10 interaction in patients with coronary artery disease The chemokine network in relation to infarct size and left ventricular remodeling following acute myocardial infarction Serum interferon-gamma-inducible protein 10 level was increased in myocardial infarction patients and negatively correlated with infarct size Plasma chemokine levels are associated with the presence and extent of angiographic coronary collaterals in chronic ischemic heart disease Elevated serum levels of the CXCR3 chemokine ITAC are associated with the development of transplant coronary artery disease Coronary collaterals improve prognosis in patients with ischemic heart disease Left ventricular dysfunction and CXCR3 ligands in hypertension: from animal experiments to a population-based pilot study Circulating CXCL-9,−10 and−11 levels improve the discrimination of risk prediction models for left ventricular dysfunction Google Scholar CXCL10 is a circulating inflammatory marker in patients with advanced heart failure: a pilot study Differential expression of the IFN-γ-inducible CXCR3-binding chemokines and IFN-inducible T cell α chemoattractant in human cardiac allografts: association with cardiac allograft vasculopathy and acute rejection Szokodi I and Dézsi CA (2018) The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction Received: 11 March 2018; Accepted: 06 August 2018; Published: 27 August 2018 Copyright © 2018 Szentes, Gazdag, Szokodi and Dézsi. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Csaba A. Dézsi, ZGNzYTYyQGdtYWlsLmNvbQ== †These authors have contributed equally to this work which continues through the weekend at the Bloc downtown demonstrates how the pas de deux—the quintessential dance duet—has evolved over the course of 400 years but don’t expect to snooze in your stage-level seat Jones’s talks are lively and company members do all the sweaty stuff performing six pieces within the hour-long program We spoke with Jones during final rehearsals In addition to pas de deux excerpts from Giselle, TheSleeping Beauty which others are being performed?We’re dancing Folies D’Espagne from the Baroque era It is based on a dance that was banned in Spain for its "extraordinary obscenity." The French version is more restrained I can see why the religious authorities of the time might have taken issue We’re also dancing Celeste Giglio from the Renaissance which was dedicated to a duke and duchess of Parma which is one of the few dances we can reconstruct from that era and has that definition changed over time?Yes The term pas de deux in the contemporary sense really comes into use in the 19th century there are dances designed for a man and a woman but without a specific term because it was the assumed form of most social dances (just as in the 19th century you wouldn’t need to say "a waltz for a man and a woman") The expectation of what a pas de deux includes changes over time a grand pas de deux encompasses a slow partnered dance between the man and the woman followed by a shorter solo dance for each and then a coda where they alternate dancing fast virtuosic steps This is the form of our excerpt from The Sleeping Beauty. Our 20th-century pas de deux from Agon has these same elements Emily Parker and Mate Szentes rehearsing George Balanchine's Agon What distinguishes each of the six pas de deux And do they have any similarities?The Renaissance dance is essentially choreographed social dancing I could probably teach the individual steps to most of the audience without much difficulty The fact that it is choreographed into a four-minute sequence and with some sense of style I think would challenge anyone Baroque dance is still choreographed social dance (the theatrical dance of the time wasn’t much different stepwise) and much more difficult to perform well with style Even though Baroque dance was performed primarily by "amateurs," they were very serious about dance and highly skilled I think the virtuosity of some of the steps would challenge any professional dancer today ballet looks much like we think of it today but the woman is not yet dancing on her toes and there is also a big emphasis on storytelling in the dance pointe work pervades most of the woman’s choreography I think the thing that distinguishes our 20th-century excerpt is its deep connection with music of greater complexity What remains the same throughout all these dances is a palpable dynamic between the man and the woman though that dynamic is a little different in each case and the fact that they are moving to music together which is probably as old as humanity itself Why did you select these particular pieces to illustrate the development of ballet as an art form?I thought the most important thing was to select a single dance form because then we could see everything change around it: the choreography I chose the pas de deux because it was the most pervasive social dance form (which gave me a lot of options for the earlier eras) and is often the centerpiece of later ballets I chose these particular dances because of their quality and because they exemplify their eras And with the Vestris Gavotte, as I mentioned it comes from a time when we aren’t able to reconstruct many of the dances Any particular challenges during the research and rehearsal process?There are rapturous descriptions of dancers from each of these periods I wondered what it was about the dancers' appearance that produced such impressions and I wanted to try and re-create that effect I wanted to see what the Fred Astaire and Ginger Rogers of the Baroque era looked like It takes a special dancer for that—one who is willing to immerse him or herself in a new style to a degree where they can really dance through it I think dancers today are required to be so explosively athletic that it can be difficult for them to approach choreography she really threw herself into the Baroque and made it live The result doesn’t look "historical" but sensual The possibilities I have seen through this process have made me want to delve even deeper into each of these eras which I am going to do over subsequent seasons What historical source material did you use?The earlier dances were notated in their own time by the choreographers and we had the assistance of Baroque dancer Justin Coates I did a lot of the costume research myself because the costumes have a substantial effect on the dancing in some cases The research was actually half the fun; it was fascinating to read the advice given by dancing masters in their manuals Renaissance dancing master Antonius Arena advises “Always maintain a smiling aspect when dancing and Some people look as if they are weeping and as if they want to shit hard turds…” For a schedule of performances, go here Thelma Golden will celebrate Lauren Halsey and U.K.-based singer Griff will take the stage featured A-list designers and Otis College standouts who earned scholarships for innovation in Fashion Design lawyers say Boston Police Officer John O'Keefe showed injuries consistent with a dog attack and plan to present a case against Chloe a German Shepherd who was re-homed by the owner's of the house where the cop's body was found in a snowbank Magazine’s takeaways on five notable topics from President Donald Trump’s first 100 days of his second term consumers are stocking up on household items and bites from THEBlvd and Hinoki & the Bird This work, Flawless execution by US, Hungary crossing over Mosoni-Duna River, by SGT Shiloh Capers, identified by DVIDS, must comply with the restrictions shown on https://www.dvidshub.net/about/copyright. Notifications can be managed in browser preferences. I would like to be emailed about offers, events and updates from The Independent. Read our Privacy notice Country music has helped a fuel tanker driver from Northamptonshire tackle a thousand-mile journey from the UK to Romania as part of a major Nato training exercise Around 2,500 British personnel, along with hundreds of vehicles, are moving across Europe by land air and sea to take part in Steadfast Dart Lance corporal Lee Moulton, 30, from Kettering, has described the 1,400-mile journey to Romania as a “long drive” with country music helping keep him going. Speaking to the PA news agency, he said: “Nothing has happened out of the ordinary, but it’s been different to driving in the UK. “It’s been an experience, I’ve deployed to a few countries before and this road move is definitely something different. “Luckily, we all know each other, we’ve worked with each other back in the UK. “So when it comes to listening to music or playing games, you find ways to entertain yourself when you’re on the road, it’s just the two of you, no comms.” Steadfast Dart comes ahead of the third anniversary of Russia’s invasion of Ukraine on Friday, with much of the exercise taking place in Romania, which borders Ukraine. The exercise is the first major deployment of Nato’s Allied Reaction Force (ARF), which replaced the Nato Response Force last year, and is intended to test Nato’s ability to deploy under pressure. “Working with the Hungarians and other militaries has been really good,” LCpl Moulton, who is based in Abingdon, Oxfordshire said. “There’s been a language barrier, but you get that wherever you go, even if you go on holiday you’ll get that language barrier, but you always find the way around it.” He is part of a group of British troops that arrived at a Hungarian military base in Szentes on Tuesday morning, where their vehicles were checked over following their mammoth journey and prepared for their time on exercise in Romania. British troops set off from Marchwood in Hampshire last week, with around 730 vehicles, including Foxhound patrol and Jackal high mobility weapons platform vehicles, Mastiff armoured patrol vehicles as well as fuel tankers and forklift trucks, fitted on to three ferries at the Sea Mounting Centre. The Royal Scots Dragoon Guards and the 4th Battalion, The Royal Regiment of Scotland have been deployed for the exercise in Romania. The two regiments, part of 7 Light Mechanised Brigade – known as The Desert Rats – will form the main battlegroup supported by other UK forces and representatives from other Nato nations. SearchHave your say - Join our Online Community and help make a difference Great Britain’s senior women rounded out their preparation for next month’s European Water Polo Championships by retaining the Danube Cup in Szentes The squad of 16 players won four and suffered one defeat on penalties to top the standings with 13 points The competition of six teams included four nations that are a part of the tournament in January as well as hosts Szentes and Hungarian club side Dunaújvárosi FVE (DFVE) Two of those in Germany and Slovakia are part of Great Britain’s group for the European Championships giving the team the best possible preparation for their trip to Eindhoven Their road to the title – which they previously won in June –  started with a 20-15 win in the opening match against Szentes An impressive first half display saw GB lead 10-4 after two quarters thanks to braces from Amelie Perkins Kathy Rodgers also got on the scoresheet to end the second quarter before she completed her hat trick as Great Britain comfortably saw out the match up Cutler and Turner also got their third as Perkins netted five in total to fire Great Britain to three points They followed that up with a 12-9 victory against European Championship opponents Germany to round out the opening day A fast start was once again key to Great Britain’s victory with Lily Turner’s five strikes putting the game beyond reach for the Germans An 8-4 lead at the interval allowed GB to manage the game expertly from there on out with the goals spread across the squad Izzy Howe and Brooke Tafazolli completing the scoring A hard fought victory against Serbia to start day two saw them make it three wins from three Nick Buller’s squad came back from 1-3 down at the end of the opening quarter to come away with a 9-7 victory Goalkeeper Sophie Jackson was the star of the show saving two penalties which sent her on the way to winning the tournament’s top goalkeeper award Her performance helped Great Britain turn the game on it’s head in the third period moving in to a 7-6 lead before late strikes from Perkins and Lotte Van Wingerden sealed the game for GB A dramatic penalty shootout then saw Great Britain’s only loss after a competitive match against DFVE The Hungarian side pulled three goals clear in the second quarter but Great Britain fought back to bring the game level at 15-15 at full time thanks to Cutler’s penalty with just 46 seconds to go That meant the match was decided on penalties which unfortunately finished 6-5 in favour of the Hungarian side – giving them a 21-10 win DFVE were however beaten by Serbia to start the final day meaning that victory for Great Britain against Slovakia would see them lift the trophy once again bouncing back to end an excellent tournament with an impressive 11-4 win Great Britain controlled the game from the off and conceded just once in the first three quarters as they strolled to victory Vicki Hawkins top scored in the match with four whilst Howe added to more to her tally to wrap up the competition in Szentes Amelia Peters and Katie Brown née Hesketh all got on the scoresheet in another strong display DFVE ended in second place on 11 points – just two behind Great Britain – with hosts Szentes in third on nine. You can find all the match sheets and the final table on the Danube Water Polo League Facebook page. Great Britain’s senior women’s European Championships campaign gets underway in Eindhoven on Friday 5 January where they have been drawn in Group D alongside Germany The physicians and staff of Southwest Women&#8217;s Health recently joined Community Physicians of Indiana Southwest Women&#8217;s Health includes Jim Perry the office name has changed from Southwest Women&#8217;s Health to Community South OB/GYN effective Oct The group will continue to maintain two office locations: 1215 Hadley Road The physicians will continue to deliver babies at St Francis Hospital-Mooresville and Community Hospital South The practice can be reached by calling 317-834-3700 or visiting communitysouthobgyn.com Surgeon General Tamás Szentes appointed Hungarian Association of Public Health Training and Research Institutions at the Debrecen conference of the latter to prepare a new national public health program “Creating a new national public health program is a huge task for our country for implementing which Office of the Chief Medical Officer of State has asked this association to be its partner in the process We wish to build upon an organization which comprises the relevant experts who can be in charge of establishing the right strategy We only have a few months to complete this assignment and then we need to come up with results as soon as possible in order to improve the currently less than ideal health condition of the population of Hungary,” said Tamás Szentes at the opening of the conference held on August 31 at Faculty of Public Health of the University of Debrecen The organization called Hungarian Association of Public Health Training and Research Institutions was established ten years ago and today it incorporates as many as thirty member institutions “These institutions include national and university-based institutes in addition to Debrecen’s Faculty of Public Health the only institution of higher education of this kind in Hungary The Faculty of Public Health of the University of Debrecen plays a significant part in this cooperation since it conducts projects in virtually all the fields of public health ranging from the prevention of diseases through occupational health and safety issues to the utilization of genetic research findings,” said Professor Róza Ádány At the conference held at the Faculty of Public Health of UD there is going to be more than sixty presentations altogether delivered in as many as eight different sections before September 2 on a wide variety of topics including the mental health of schoolchildren the level of the knowledge of young Hungarians about resuscitation and first aid and the typical diseases homeless people in Hungary most often suffer from redazione@wpdworld.com Again the nations with the stronger waterpolo tradition dominated the U20 World Championship in Almaty but looking beyond the first positions achieved  at the tournament in Kazakhstan you’ll find a team that has made wonderful progress: Egypt the North Africans have ended the World Cup getting the tenth position improving their position of five compared to Volos 2013 (they got the 15th position) and he returned to Cairo for a common training for his two teams but this summer the Egyptian federation asked me to become the person in charge for all the national teams meanwhile I’ve started working with the U20 the best in the history of Egyptian water polo When the preparation for Almaty has started We worked for two months in Cairo at the Olympic stadium and then we attended the Vikelas Cup along with Italy It was the first tournament ever for this group but overall the fact that we were able to score 9-10 goals against several top teams gave us high hopes for the World Cup In Kazakhstan you got also to beat an European team of good tradition such as Netherlands but not only for the victory against Netherlands I think that even the defeats for 3 goals against Montenegro (14-11) and 4 against Spain (15-11) are to consider great results As it was technically impossible to reach the level of European teams I aimed essentially to improve the physical and athletic aspects the guys have worked very hard to become competitive This is also confirmed by the statistics of the match: against Netherlands we were 12-11 at the end of the third quarter but at the end we had more energy and we scored a partial of 3-0 Among your players there’s anyone who could long for an European club He played on a level that is comparable to a top young European player and he also knows how to play center forward he is a ’96 and I hope he will have an international career Do you think the experimental rules have encouraged the growth of Egypt I think that even in a tournament 7 vs 7 this team would have done good After only one event it is hard to figure out whether the new rules are positive or not for the teams that are traditionally less strong What I approve is the pool reduction to 25 meters the rhythm is high and there is no downtime it’s a big change for the players and it was also cause of some injury to their shoulders as they are used to the normal size leads to a sport that is totally different being an advantage for the stronger teams only Generally speaking it would be interesting to discuss about this with the laymen Provided that water polo is to play  7 vs 7 do you think the 6 vs 6 can shape up the young players The 6 vs 6 game forces the water polo players to move more and also to get better technically speaking Reducing the number of elements in the bench is risky: every club could eliminate 2-3 players for each youth team and so we would see the total number reduced what is the situation of water polo in Egypt Here the water polo is a quite popular sport some clubs have an incredible number of kids and for an European it is surprising to find out how many young people practice this sport The main problems for an actual development are two The first is that there is no professional league so there’s a large number of dropouts The activity begins around 13 years and goes up to 20 with youth and senior leagues of 9 teams: the majority in Cairo some of those are involved in youth leagues only The other problem is that the sport is practiced only by boys enrolled in clubs that have availability of very good plants and facilities The standard and the costs of these clubs are various but generally those are inaccessible to the poorest section of the population Have you worked in cooperation with The Egyptian federation to a development plan for water polo we’re discussing about it during these days It is a program that aims to the Olympics in Tokyo 2020 Now it’s up to the Federation to continue with me or not In Africa the only other national team is in South Africa too far away to manage to compete frequently Egypt needs to participate in competitions based in Europe and in Asia Are you thinking about attending to the European competitions as well The top Egyptian teams should play the preliminary qualifications and the national team the qualifications in Europe This would be a great way to promote the development of water polo in Egypt Indeed the country is far closer to Europe than to South Africa After all Fina aims to have a high level team in Africa since long time It is in water polo worldwide interest that Africa is well represented internationally Furthermore  the survival of water polo at the Olympics actually depends also from Egypt must be practiced in all five continents: Egypt may represent Africa For several years Gezira is participating to HaBaWaBa International Festival: is this tournament fostering the development of water polo in Egypt The HaBaWaBa is now the greatest international competition for children and the young Egyptians are very excited to participate It’s a big step in order to get the young people to love water polo then it’s up to the local and the international federation to educate the coaches and to build a system for the development of our sport https://www.wpdworld.com http://www.habawaba.com Dawn Cunningham with a portrait of her late son Gabi Photo: VINNIE VAN OORSCHOT ONE in two Australians will be affected by cancer in their lives according to Cancer Council Australia which is why it is more important now than ever to contribute to this year’s Daffodil Day Appeal on August 27 Surf Coast resident Dawn Cunningham is a Daffodil Day ambassador and a remarkable woman who was diagnosed with breast cancer in 2011 but is now in remission The Torquay resident was able to overcome her illness cancer has had an ever-lasting impact on her life after both her mother and her 14-year-old boy Gabi passed away from it Overcoming her own challenges has certainly had a tremendous effect on her life but Ms Cunningham continues to mourn her late son Gabi Szentes passed away in the second decade of his life from Non-Hodgkin’s Lymphoma originating from a tumour the size of a cricket ball located near his heart Gabi underwent chemotherapy and radiotherapy remaining headstrong during his intense sessions insisting on wearing a bandana and returning to school and his only option was to undergo an extremely risky chemotherapy treatment to be flown in from France Before he could undergo what felt like was he and his family’s final hope Ms Cunningham says she thinks about Gabi every day since he passed away 21 years ago highlighting how much potential he had at such a young age “He was a straight A student at St Joseph’s College in Geelong he was flying a two-seater aircraft with his instructor at Barwon Heads Airport he was going for his black belt in karate just before he passed away and his dream was to become a fighter pilot with the Royal Australian Airforce (RAAF),” Ms Cunningham said “There is nothing worse than losing a child just treasure them like anything because it happened just like that “He had so much to live for and so much to give.” St Joseph’s presents the Gabi Szentes Memorial Award to a student they feel has followed in Gabi’s footsteps Gabi has also inspired his mother to become a committed advocate for the Daffodil Day Appeal Ms Cunningham held her Biggest Morning Tea at the Star of the Sea retirement village in Torquay back in 2017 and received tremendous support from the local businesses in the area She called for each business to donate one gift to the event where Ms Cunningham would help auction them off to those who attended Her efforts have helped raise thousands of dollars for the Daffodil Day Appeal and more than $10,500 has been raised through the Cancer Council’s Biggest Morning Tea initiative this year alone “For research,” said Ms Cunningham when asked why people should donate to the Cancer Council “I just want further research towards cancer “The only way we can afford getting medication instruments and machines is if there is money sitting there.” To donate to the Daffodil Day Appeal head to daffodilday.com.au This year’s biggest NATO military drill will happen in Romania Bulgaria and Greece in February including nine NATO member states as participants The Steadfast Dart 2025 will be held between 7 and 21 February and more than 400 British soldiers will participate They will travel to Romania via Hungary and our country is prepared to provide supplies and accommodation during their journey The first British convoy is to enter the country tomorrow According to index.hu the British soldiers will come to Hungary on 20 January and are planning to leave our country on 22 January They will travel across Hungary following the Rajka-Pápa-Szentes-Nagylak route They will cross the Romania-Hungary Schengen border at Nagylak According to the Hungarian defence minister, Kristóf Szalay-Bobrovniczky the military bases of Pápa and Szentes will provide supplies places to rest and accommodation for the more than 400 British soldiers They will receive similar help on the backward journey in February Steadfast Dart 2025 will be the biggest NATO military drill in the region this year Approximately 10,000 soldiers are to participate from six countries (the United Kingdom and Türkiye) accompanied by the armed forces of the three hosts (Romania The military drill aims to test the skills and capabilities of the NATO Allied Reaction Force (ARF) This will be the unit’s first such mission The participants have time until 7 February to arrive in the host countries which is their first test examining the deployment time and organisation of the troops Szalay-Bobrovniczky said Hungary was committed to carrying out its tasks as a NATO member since that is fundamental to implementing our international security strategy So what is the threat are we preparing to defend ourselves Our Politicians have expressed the desire to get chummy and website in this browser for the next time I comment Y"},"category":false,"taxonomy":{"active":false,"name":"category"}},"markup":{"custom_html":true,"wpp-start":"","wpp-end":"<\/ul>","title-start":"","title-end":"<\/h2>","post-html":"{thumb} {title} {stats}<\/span>{excerpt}<\/p><\/li>"},"theme":{"name":""}} You have successfully joined our subscriber list SupportUs Newsletter © 2025 DailyNewsHungary | All rights reserved The Hungarian Defence Ministry said in a statement today that residents of Eastern Hungary should expect lots of military vehicles on Monday Increased military traffic is to be expected between Hajdúhadház and Szentes in Eastern Hungary tomorrow the Hungarian Ministry of Defence said today the Hungarian part of the multinational TISZA Technical Battalion will take part in a drill from the early hours of Monday many military vehicles will be on the roads between Hajdúhadház and Szentes Hajdúhadház – main road 4 – main road 354 – M35 motorway – road 47 – Berettyóújfalu – 47 – Szeghalom – main road 47 – Gyomaendrőd – road nr 443 – Szarvas – main road 45 – Szentes – main road 45 – Szentes Hajdúhadház – main road 4 – Debrecen – main road 4 – Püspökladány – 4 – Kenderes – 4 – Szajol – 4 – Szolnok – 4 – main road 442 – Rákóczifala – 442 – Martfű – 442 – main road 44 – main road 45 – Kunszentmárton – 45 – main road 451 – Szentes The Hungarian defence forces would like the residents to keep all rules and be cautious when approaching military vehicles and length of such convoys may differ from those they are used to it is forbidden for any civil vehicles to join the military convoys The approach of such convoys is guaranteed by accompanying vehicles they ask everybody to consider visibility and weather circumstances provided they get around the convoys They added they would like to cause the least inconvenience for the citizens demonstrates the alliance’s capability of tackling the crisis situation in the eastern region and the collaboration of member states a senior army official said at a Hungarian military base on Tuesday The British troops participating on the drill are already in Hungary “The help with logistics and national support is as much a part of the NATO exercise as the execution of its tasks,” Colonel Attila Csurgó the commander of a technical regiment of the armed forces said in Szentes The British troops that are on their way to Romania to participate in the exercise had made a stopover before at the army base in Pápa in north-western Hungary and arrived in Szentes during the night carrying their equipment “There are currently 120-140 British soldiers staying here at the base and there will be more of them arriving here during the night.” According to a statement by the defence ministry some 10,000 troops from nine NATO countries will participate at the Steadfast Dart 2025 exercise which will be held in Bulgaria