The G7 Foreign Ministers’ Meeting to be held in Fiuggi and Anagni from 25 to 26 November 2024 will be the second to be hosted in Italy in 2024 after the one held in Capri from 17 to 19 April.Under the Italian Presidency on the sidelines of major international events in Munich the aim is to strengthen the G7’s role as the main forum for consultation among the major liberal democracies and as a factor for stability in the face of the major crises taking place at the global level the agenda of the Fiuggi Ministerial Meeting will focus on the main issues at the heart of the international debate starting with the situation in the Middle East following Hamas’s brutal terrorist attack against Israel on 7 October 2023 Among the topics under discussion will be the serious humanitarian crisis in Gaza and the need to promote a credible political horizon for the region that guarantees peace and security A discussion on the war in Ukraine in the face of Russia’s aggression is also planned The Italian Presidency intends to confirm the G7’s full military Italy will host the Ukraine Reconstruction Conference on 10-11 July 2025 a priority region for political balances and world trade Major regional issues and global topics will also find their way into the debate analytical cookies with technical features and third-party profiling cookies to ensure the best browsing experience and allow you to view some content in line with your preferences To find out more, see our Privacy Policy. 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Please enable JS and disable any ad blocker The top diplomats met for the final time before a new U.S. administration takes office with wars raging in the Mideast and Ukraine. “Knock on wood,” Italian Foreign Minister Antonio Tajani said as he opened the Group of 7 meeting outside Rome. “We are perhaps close to a cease-fire in Lebanon,” he said. “Let’s hope it’s true and that there’s no backing down at the last minute.” A cease-fire in Gaza and Lebanon was foremost on the agenda of the G-7 meeting in Fiuggi, outside Rome, that gathered ministers from Canada, France, Germany, Italy, Japan, the United Kingdom and the United States, in the last G-7 encounter of the Biden administration. For the first time, the G-7 ministers were joined by their counterparts from Saudi Arabia, Egypt, Jordan, the United Arab Emirates and Qatar, the so-called Arab Quintet, as well as the secretary general of the Arab League. “Everyone favors a cease-fire in both scenarios,” Tajani told reporters, adding that Italy had offered to take on an even greater peacekeeping role in Lebanon to oversee any cease-fire deal. As the ministers arrived in Italy, Israel’s ambassador to the U.S., Mike Herzog, told Israeli Army Radio on Monday a cease-fire deal to end fighting between Israel and the Lebanon-based Hezbollah could be reached “within days.” Several Arab ministers reiterated calls for a cease-fire in Lebanon and Gaza during a G-7-affiliated conference in Rome. World & Nation The Group of 7 foreign ministers is meeting on the resort island of Capri amid calls for new sanctions against Iran. “We need a cease-fire, a permanent cease-fire. That will stop the killings and stop the destruction and restore a sense of normalcy to life,” Jordanian Foreign Minister Ayman Safadi told the conference. Egyptian Foreign Minister Badr Abdelatty, for his part, reaffirmed that Cairo would host a minister-level conference next Monday on mobilizing international aid for Gaza. The so-called “Quintet” has been working with the U.S. to finalize a “day after” plan for Gaza. There is some urgency to make progress before the Trump administration takes over in January. President-elect Donald Trump is expected to pursue a policy that strongly favors Israel over the aspirations of the Palestinians. Tajani added another item to the G-7 agenda last week after the International Criminal Court issued arrest warrants for Israeli Prime Minister Benjamin Netanyahu, his former defense minister and Hamas’ military chief. Italy is a founding member of the court and hosted the 1998 Rome conference that gave birth to it. But Italy’s right-wing government has been a strong supporter of Israel after the Oct. 7 Hamas attacks, while also providing humanitarian aid for Palestinians in Gaza. The Italian government has taken a cautious line, reaffirming its support and respect for the court but expressing concern that the warrants were politically motivated. The United States, Israel’s closest ally, has called the warrants “outrageous.” Tajani acknowledged consensus hadn’t been reached among the G-7 members but hoped for agreement to have a unified position. He noted that all sides need Netanyahu to make any deal. “We can also not agree with how his government has led the reaction after the massacre of Oct. 7, but now we have to deal with Netanyahu to arrive at peace in Lebanon, peace in Palestine,” Tajani said. Nathalie Tocci, director of the Rome-based Institute for International Affairs think tank, warned that inserting the ICC warrant into the G-7 agenda was risky, since the U.S. is the lone member that is not a signatory to the court and yet tends to dictate the G-7 line. “If Italy and the other [five G-7] signatories of the ICC are unable to maintain the line on international law, they will not only erode it anyway but will be acting against our interests,” Tocci wrote in La Stampa daily this weekend, recalling Italy’s recourse to international law in demanding protection for Italian U.N. peacekeepers who have come under fire in southern Lebanon. Foreign ministers from the Group of Seven nations revealed stark divergences in views on the Middle East on Saturday as they wrapped up a meeting in France that opened with the goal of finding common ground on contentious global challenges but was shaken by the absence of U.S. The other major talking point of the G-7 meeting is Ukraine, and tensions have only heightened since Russia attacked Ukraine last week with an experimental, hypersonic ballistic missile that escalated the nearly 33-month-old war. Russian President Vladimir Putin said the strike was retaliation for Kyiv’s use of U.S. and British longer-range missiles capable of striking deeper into Russian territory. The G-7 has been at the forefront of providing military and economic support for Ukraine since Russia’s invasion in February 2022 and G-7 members are particularly concerned about how a Trump administration will change the U.S. approach. Trump has criticized the billions of dollars that the Biden administration has poured into Ukraine and has said he could end the war in 24 hours, comments that appear to suggest he would press Ukraine to surrender territory that Russia now occupies. “It’s hugely important that this G-7, that all colleagues across the G-7 continue to stand with Ukraine for as long as it lasts,” British Foreign Secretary David Lammy said as he arrived. He announced new sanctions on vessels of Russia’s “shadow fleet” of ships that are evading sanctions to export Russian oil. “And we are confident that Ukraine can have the funds and the military equipment and kit to get through 2025,” Lammy said. The G-7 foreign ministers’ meeting, the second of the Italian presidency after ministers gathered in Capri in April, is being held in the medieval town of Fiuggi southeast of Rome, best known for its thermal spas. On Monday, which coincides with the International Day for the Elimination of Violence Against Women, ministers were attending the inauguration of a red bench meant to symbolize Italy’s focus on fighting gender-based violence. Over the weekend, tens of thousands of people marched in Rome to protest gender-based violence, which in Italy so far this year has claimed the lives of 99 women, according to a report last week by the Eures think tank. Winfield writes for the Associated Press. Subscribe for unlimited accessSite Map an important training activity of the Atlas network an international network made up of 38 groups of special intervention forces organized by the Central Security Operations Unit – Nocs of the State Police The Nocs is the “leatherhead” central security operations unit of the Central Directorate of Prevention Police the Nocs intervened on a high-speed train of the Italian State Railways that having left yesterday afternoon from the Milan Central station reported an emergency due to a terrorist threat on board The presence of passengers on the train was simulated by State Police officers in civilian clothes The anti-terrorism exercise was managed by the National Command and Control Operations Room of the Italian State Railways in Rome where the heads of the Operations Teams of the special forces involved worked closely with officials of the Italian State Railways The exercise ended late at night in the Anagni station with the intervention of the men of the Nocs of the State Police who arrived on site aboard three helicopters of the Air Force After the scenario analysis and the definition of the tactics the Nocs stormed the moving train and neutralized the threat Operators from other special units of the Atlas network also participated in the exercise The Nocs of the State Police reached Anagni with three helicopters of the Air Force: two HH139 of the Sar (air search and rescue) and an HH-101 used to support special operations These specialized assets and crews of the Air Force are able to operate in complex operational and environmental contexts thanks to specific capabilities at a national level such as the qualification for night operations with the use of special NVG viewers and the ability to operate at long distances from the home base and for extended periods through in-flight refueling actively participated in the Atlas Group exercise by making its assets and personnel available to support the activities The exercise is part of those envisaged in the annual plan of the FS Italiane Group coordinated by the Security function of the FS Holding and has the objective of monitoring the effectiveness of the communication flows and the coordination system between the Bodies as well as the familiarization of the special departments with the railway infrastructure the exercise allowed to verify the methods and timing of access to the infrastructure and the coordination with the Authorities of the Ministry of the Interior which did not have any repercussions on the circulation of trains was to test the effectiveness and speed of activation of the procedures for the management of emergencies also by Ferrovie dello Stato constituting an advanced command post from where all the actions for the safety and security of passengers were decided The complex training activity organized by the Nocs was aimed not only at the management and resolution of terrorist events but also at always keeping high levels of personnel preparation coordination with other police forces and the defense sector and with public and private entities Read also other news on Nova News Click here and receive updates on WhatsApp Follow us on the social channels of Nova News on Twitter, LinkedIn, Instagram, Telegram Catalent is expanding its biologics manufacturing facility in Anagni Biologics manufacturing facility expansion US-based pharmaceutical company Catalent announced plans to expand its biologics manufacturing facility in Anagni to support the growing demand for its biologics in the European market The expansion will require a $100m investment and be carried out in multiple phases The initial phase is expected to be operational in April 2023 and increase the facility’s workforce by up to 100 employees Catalent’s existing biologics manufacturing and packaging facility covers a 28,000m² area in Anagni The expansion’s first phase will involve building purpose-built manufacturing suites which will feature two 2,000l single-use bioreactors Additional infrastructure will be developed to support the installation of six more 2,000l single-use bioreactors Investments to support early-phase clinical development as well as late-stage and commercial tech transfers Catalent plans to add 16,000l of total flexible manufacturing capacity in the subsequent phases to enable production in batches of between 2,000l and 8,000l The latest investment is intended to advance drug substance manufacturing at the facility It will complement the plant’s existing capabilities including expertise in aseptic vial filling and secondary packaging of biologic It will also allow the site to offer new integrated drug substances and drug products In January 2020, Catalent acquired the facility from Bristol-Myers Squibb (BMS) The site served as a primary launch facility for new Bristol-Myers medicines for several conditions Catalent continued the production of the BMS products that had previously been manufactured at the site. The company also added biologics and oral solid dose manufacturing and packaging capabilities to the Anagni site Catalent’s Anagni facility offers sterile and biologics capabilities as well as secondary oral dose commercial packaging solutions It has the capacity for vial filling for aseptic liquid and powder products The plant offers drug development and manufacturing services using Catalent’s knowledge of the launch and supply of small molecules vaccines and biosimilars from preclinical to commercial stages The facility delivers primary and secondary packaging solutions It also has automated warehousing and serialisation capabilities Catalent’s flexible layouts help to inspect as well as supporting device assembly and final packaging services The facility’s automated assembly for auto-injectors pre-filled syringes and other safety equipment uses state-of-the-art high-speed equipment to support the rapid supply of pharmaceutical products the high-speed filling lines offer enhanced aseptic processing the Anagni facility has been a major European hub for the production of Johnson and Johnson’s (J&J) Covid-19 vaccine Catalent expanded its partnership with J&J in March 2021 to significantly increase the Anagni facility’s sterile manufacturing and packaging capacity for large-scale commercial supply of J&J’s Covid-19 vaccine The companies also agreed to dedicate an existing vial-filling line at the facility to production of the vaccine Catalent will expedite the qualification and scaling-up of an additional high-speed vial-filling line, with the aim of commissioning it in the fourth quarter of 2021. The high-speed line will support the production of J&J’s Covid-19 vaccine until late 2022 Give your business an edge with our leading industry insights View all newsletters from across the GlobalData Media network under the chairmanship of Deputy Prime Minister and Minister for Foreign Affairs and International Cooperation Antonio Tajani met in Fiuggi and Anagni on 25 and 26 November and adopted a joint Statement Nestled at the base of the Ernici Mountains in Ciociaria Fiuggi is a charming medieval town where visitors can admire architectural gems such as the Municipal Theatre designed by architect Giovan Battista Giovenale the alleys of the historic centre have been further enhanced by vibrant street art transforming it into a true open-air museum Renowned as a spa destination since the Middle Ages due to the waters that flow from its natural springs and the surrounding mountains Fiuggi is now one of Europe’s most important spa resorts Michelangelo praised the diuretic properties of its mineral water famously calling it the water that breaks stones apart Fiuggi is a prominent attraction for the entire region Its economy primarily relies on tourism and events it boasts the highest number of hotels in Lazio and hosts a variety of significant national and international events each year Anagni is a city that rises on a hill over 400 meters high overlooking the Sacco Valley in southern Lazio and has historically served as a papal residence The medieval centre showcases elegant buildings and squares characterized by their sober and essential architecture It houses significant treasures such as the 13th-century Palace of Boniface VIII the Cathedral stands out with its magnificent crypt which contains one of the most intriguing cycles of frescoes from 13th-century Italy Anagni experienced a remarkable economic boom driven by the establishment of numerous companies that transformed it into one of Lazio's most prosperous centres To find out more, see our Privacy Policy By closing the banner through the X at the top right or by selecting the "Reject all" button you will continue browsing and receive only the technical cookies for which your consent is not required but the contents of the YouTube channel will not be available directly within this Site If you wish to consent to the use of third-party profiling cookies select the "Accept all" button; remember that you can always change your choice using the Cookie Preferences feature available at the bottom of the page Metrics details yet continuous sedimentary succession covering the time interval spanning 2.6–0.36 Ma in the intramontane basin of Anagni (central Italy) through a dedicated borecore and the review of previous data at the three palaeontological and archaeological sites of Colle Marino By combining the magneto- and chronostratigraphic data with sedimentologic and biostratigraphic analysis we describe the palaeogeographic and tectonic evolution of this region during this entire interval the progressive shallowing and temporary emersion of the large lacustrine basins and alluvial plains created favorable conditions for early hominin occupation of the area as attested by abundant tool industry occurrences and fossils This study provides new constraints to better interpret the hominin migratory dynamics and the factors that influenced the location and spatial distribution during the early occupation of this region (a) Digital Elevation Model (DEM) image TINITALY/01 square WA 6570 of central Italy showing location of the Latin Valley and (b) of the investigated archaeological sites Used with permission of the Istituto Nazionale di Geofisica e Vulcanologia Simplified stratigraphic log of the Colle Marino borehole (CM1). For detailed lithological description and sampling, see Figure S2 in Supplementary Material #1 The clay succession occurring between 5 and 35 m bgs recovered from the CM1 core was sampled for palaeomagnetism using standard 8 cm3 plastic cubes with the arrow on the sampling cube’s bottom pointing up-core We collected 81 samples from the center of the split-core sections as this is less affected by coring disturbance The samples were oriented only with respect to the vertical; the geocentric axial dipole (GAD) field at the latitude of the coring site has an inclination of ± 61° which makes it feasible to reconstruct palaeomagnetic polarity using only Characteristic Remanent Magnetization (ChRM) inclinations samples were packed in sealed bags and stored in a refrigerated room until they were processed at the INGV in Rome In order to provide geochronologic constraints to the sampled interval the core was initially scrutinized in order to detect macroscopic tephra layers One sub-primary fallout deposit was observed between 29.70 and 29.80 m bgs and sampled for 40Ar/39Ar dating Four additional bulk sedimentary samples were collected at 2.60 5.10 and 11.50 m bgs for detrital sanidine dating (see methods section) in the fine-grained section between 7 and 35 m bgs ten samples for biostratigraphic and sedimentological analysis were extracted Natural and artificial magnetizations were measured using a narrow-access pass-through cryogenic magnetometer (2-G Enterprises model 755R) with internal diameter of 4.2 cm equipped with three DC SQUID sensors (noise level 3 × 10−9 A m2 kg−1) housed in a Lodestar Magnetics shielded room (ambient field < 200 nT) mineral magnetic analyses were conducted on the same set of discrete samples Low-field magnetic susceptibility (κ) was measured using an AGICO KLY-5 Kappabridge magnetic susceptibility meter with a sensitivity of 2 × 10–8 SI An anhysteretic remanent magnetization (ARM) which is particularly effective in activating finer magnetic grains was imparted by using a 0.05 mT direct current (DC) bias field superimposed on a 100 mT peak AF and by translating samples through the AF and DC coil system at 10 cm/s which is the lowest speed allowed by the control software Samples were measured in air up to a maximum temperature of 700 °C and the thermomagnetic curves were analyzed using the Cureval8 program Different crystal phases were extracted from five samples of sediment (CSG-13 2A aimed to provide terminus post-quem (maximum age) to the time of deposition and from one sample of a primary fallout deposit (CM1-29.75) CM-11.5 did not yield K-bearing mineral phases suitable for 40Ar/39Ar dating Pristine sanidines and few leucites ranging in size between 1 mm and 300 µm were otherwise found in the sample CM1-3.9 = (0.580 ± 0.007) × 10−10 yr−1 and λβ¯ = (4.884 ± 0.049) × 10−10 yr−1) To determine the neutron flux of IRR CO007 flux monitors were placed in small pits framing the sample Two standards from 3 pits around the unknown were measured to calculate CM1-3.9 J-value (J = 0.0005519 ± 0.00000055) Procedural blank measurements were achieved after every four unknowns For typical 5 min time blank backgrounds are between 1.7 10−4 V and 2.0 10−4 V for 40Ar and 65 cps for 36 Ar (9.5 10−7 V equivalent) Results for all the dated samples are reported with 2σ analytical uncertainties according to the respective laboratory standards (see above). Difference due to the two different calibrations affects the third decimal figure and are negligible within the aims of this work. Full analytical data are reported in Supplementary Material #2 and subsequently washed and sieved through a 63 μm mesh and dried again at 50 °C Separates were observed under an optical microscope LEICA M165 and selected fossils were analyzed with the Scanning Electron Microscope HITACHI TM3030 Plus The semiquantitative analyses carried out on the microfossil content led to the rough indication of the occurrence of the most indicative taxa in order to identify palaeoenvironmental changes Mineral compositions were analysed at the CNR-Istituto di Geologia Ambientale e Geoingegneria (Rome) with a Cameca SX50 electron microprobe equipped with five wavelength dispersive spectrometers (WDS) Quantitative compositional analyses were performed using 15 kV accelerating voltage and15 nA beam current As standards we employed metals for Mn and Cr Counting times were 20 s for elements and 10 s for backgrounds Light elements were counted first to prevent loss by volatilization (b) stratigraphic variations of NRM intensity (e) Temperature dependence of κ (up to 700 °C) for three representative samples: CM29 (19.35 m) For samples CM29 and CM62 a three-point moving average is applied (red curves) The increase in k and ARM in the interval between 18 and 22 m corresponds to a portion of the core characterized by decimetric alternations of light sandy clays and yellowish silty sands ARM values range between 1.31 × 10–3 A/m and 4.32 × 10–2 A/m with an average of 7.44 × 10–3 A/m The single sample at the tephra level has an intensity of 1.70 × 10–1 A/m The normal polarity samples and the reverse polarity samples have a mean inclination of 57.8° (N = 13; a95 = 21.8°) and -55.6° (N = 49; a95 = 5.6°) These values are not significantly different from antipodal at the 95% confidence level and suggesting that the mean directions could indeed represent a reliable polarity record Lithology (symbols as in Fig. 3) and magnetic polarity zonation (black = normal polarity and white = reverse polarity) Relative probability diagrams showing the results of the 40Ar/39Ar dating experiments performed at LSCE (a) and at the Wiscar Laboratory (b). Full analytical data are reported in Supplementary Material #2, #3 Nineteen of 22 K-bearing plagioclase crystals give a weighted mean 40Ar/39Ar age of 2.214 ± 0.034 Ma (Fig. 7b) Three dates are markedly younger and are excluded from the weighted mean calculations These younger dates may be due to alteration or Ar loss Eighteen of 22 single plagioclase fusions from sample CSG-13 2A give a weighted mean 40Ar/39Ar age of 2.233 ± 0.032 Ma (Fig. 7b) Four older dates are excluded from the weighted mean calculations and are interpreted to be antecrysts or partially degassed xenocrysts Correlation of the new magnetic polarity zonation from CM1 with the GPTS of46 The two 40Ar/39Ar ages and the absence of products of the paroxysmal volcanic activity support a one-by-one correlation of observed magnetozones with each polarity of the GPTS from Chron C1n to C2r.2r with variable sedimentations rate up to 4.81 cm/kyr The investigated clayey succession is remarkably barren, with a total absence of any biogenic fraction in all the samples collected between 12 and 35 m bgs, as well as in one sample collected at the very top, 7.5 m bgs (Table 1) idiosyncratic calcified Charophytes thalli have been also observed in this sample (Fig the composition of amphibole is edenite with an Mg# restricted to a nearly constant value of 60–64 including apatite and is characterized by continuous normal zoning with anorthite (An47–57) content variable from core-to-rim (a) Reconstruction of the stratigraphic setting of the investigated area through the cross-correlation of the borehole data achieved in the present study and in previous work at Colle Marino (b) Sketch showing the environmental evolution of the Latin Valley in the interval 2.6–0.6 Ma after restoration of the original elevation of borehole FR2 before tectonic dislocation (see text for explanations) The age obtained for the fossil-bearing horizon at CSG suggests an earlier arrival of some species in Italy than in France and give a minimum age of 2.23 Ma for the base of the MNQ 17b biozone The chronostratigraphic constraints achieved for the sedimentary succession recovered from the borehole and documented in the field at the three palaeontological/archaeological sites show that these successions cover three distinct, partially overlapping, time intervals spanning ca. 2.6 through 0.36 Ma (Fig. 9) The tephra recovered at CM1 provides exact correlation with the fossil-bearing horizon of CSG where a nearly homogeneous K-plagioclase crystal population extracted from a sand sample yielded an identical age the lower portion of the clay section recovered from 193 to 163 m a.s.l at CSG1 displays distinct features from those detected from 220 to 192 m a.s.l recognized two near-shore facies associations at the top and at the bottom of the cored sediments separated by a thick marsh facies association with abundant organic-rich (lignite) layers once the high sedimentation rate deriving from this assumption is taken into account the possibility that the lowest normal polarity sample occurring at the base of the clay section may represent the top of the Gauss normal Chron C2An.1n (2.581 Ma) cannot be discarded a thick succession of reworked volcanic material older than the Pozzolane Rosse emplaced in fluvial-lacustrine setting at FR2 constrains the tectonic activity within the 600–450 ka time interval Paleogeographic sketches showing the sea ingression and regression phases occurring in the investigated area 2.5 Ma through 1.8 Ma DEM images used with permission of the Istituto Nazionale di Geofisica e Vulcanologia from an original westward direction towards the Aniene and Tiber rivers catchment basins has due to the emplacement of large thickness of Alban Hills pyroclastic-flow deposits since 450 ka Palaeogeographic reconstruction based on the CSG1 and CM1 borehole data discussed here suggest that a significant change in the hydrographic catchment occurred much earlier creating the conditions for the successive inversion of the river flow direction lacustrine environment characterized the Sacco Valley from 2.2 through 0.6 Ma The lacustrine deposits spanning this age interval represent the entire 35 m thick sedimentary succession recovered between 192 and 227 m a.s.l the geologic section exposed at La Vignaccia allows a correlation of the thick succession of calcareous silt with frequent carbonate encrustations cropping out between 210 and 225 m a.s.l with the coeval lacustrine succession in CM1 The top of the calcareous silt deposit reaches an elevation of 225 m a.s.l thus leading to estimate a thickness of ca 20 m for this pack of homogeneous lacustrine sediments overlying the fossiliferous horizon of CSG The “volcanic” age boundary at ~ 0.6 Ma shows that this sedimentary sequence accumulated during a time span of ca The thick suite of primary to deeply reworked volcanic materials exposed at La Vignaccia is correlated to the deposit described in the stratigraphic log of FR’s boreholes 1 and 2 occurring between 232–227 and 217–202 m a.s.l. This sequence of reworked volcanics rests on the eroded sedimentary substrate towards the depocenter of the lacustrine basin this correlation allows us to understand the palaeoenvironmental features of the lacustrine basin barren clay sediments accumulated in this area characterized by clear waters allowing photosynthetic activity of charophytes led to precipitation of autochthonous carbonates that substantially contributed to the lacustrine sedimentation The transition is marked by a decimeter-thick interval of alternating thin layers of white carbonatic silt and dark-brown the calcareous silt horizon passes upwards (the lithologic passage was not recovered in the core due to the partial loss of sampling caused by the unconsolidated features of the silt deposits) to yellow sands with abundant carbonate encrustations and travertine layers The youngest sanidine crystal out of 21 extracted from a sediment sample collected within this horizon (CM1-3.9) provided a maximum age of 688.8 ± 2.7 ka for this layer and represent an ideal environment for game and their hunters The present study provides accurate geochronologic constraints to the sedimentary succession recovered from a drilling at CM and unambiguously correlate it with those previously investigated at the nearby fossiliferous sites of CSG and the archeological site of FR Correlation of the sequence of magnetozones with the GPTS is constrained by 40Ar/39Ar ages obtained from both in situ and reworked volcanic materials The chronostratigraphic constraints show that the investigated successions cover three distinct time intervals The lower clay succession recovered at CSG records two regional sea-level oscillations corresponding to the "Piacenzian" (i.e. 3.6–2.6 Ma) and to the early "Gelasian/Santernian" (i.e. The second ingressive phase is abruptly aborted around 2.2 Ma as attested by the lack of marine deposits of Santernian age (1.8–1 A large lacustrine basin occupied the Latin Valley since 2.2 Ma providing an environment favorable to the dispersal of several "African" taxa which constitute the Middle Villafranchian Faunal Unit of CSG which is dated in the present work at 2.233 ± 0.032 Ma The age of CSG fossiliferous horizon slightly pre-dates previous assessment at the French type-locality of the MNQ 17b biozone suggesting an earlier occurrence of the African taxa in Italy than in France the progressive shallowing and temporary emersion of the large lacustrine basins created favorable conditions for early hominin occupation of the area as it is possibly documented by the lithic assemblages from CM tentatively suggested as being the origin of the lithic collection found in the site could provide a strong reference for the pre-Acheulean technocomplexes in Mediterranean Europe The human occupation of this region reaches a climax around 0.4 Ma as constrained by the chronostratigraphic framework reconstructed here for the FR site consistent with geochronologic data from recent literature achieved at this site and several other sites throughout the Latin Valley These results contribute to better interpretation of the hominin migratory dynamics and the factors that influenced the location and spatial distribution during the early stages of occupation in these regions calvarium of late Homo erectus from Ceprano A re-appraisal of Ceprano calvaria affinities with Homo erectus A cranium for the earliest Europeans: phylogenetic position of the hominid from Ceprano The site of Coste San Giacomo (Early Pleistocene central Italy): Palaeoenvironmental analysis and biochronological overview Evidence of late Gelasian dispersal of African fauna at Coste San Giacomo (Anagni Basin central Italy): early Pleistocene environments and the background of early human occupation in Europe a K-Ar dated lower and middle pleistocene site Nuovo contributo alla conoscenza delle faune villafranchiane e del Pleistocene medio del bacino di Anagni (Frosinone) 115–118 (Atti XXIV Riun Guida ai giacimenti Pleistocenici e Villafranchiani del Lazio meridionale Segre AG (2009) Nouvelles recherches dans le bassin Plio-Pléistocène d’Anagni (Latium méridional First 40Ar/39Ar age of the Ceprano man (central Italy) Geochronological evidences of a MIS 11 to MIS 10 age for several crucial Acheulian sites from the Frosinone province (Latium Fontana Ranuccio in I primi abitanti d'Europa Pleistocene magnetochronology of early hominin sites at Ceprano and Fontana Ranuccio Dal Paleolitico inferiore al Bronzo nel bacino di Anagni in Dives Anagnia dalla preistoria alla protostoria 1996) Artefacts and human teeth at the Fontana Ranuccio Middle Pleistocene Site (Central Italy A revision of hominin fossil teeth from Fontana Ranuccio (Middle Pleistocene Molluscs and Ostracods from the Middle Pliocene to the Late Pleistocene in Italy Petronio, C., Bellucci, L., Martinetto, E., Pandolfi, L. & Salari, L. 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Geochronology 2, 231–243. https://doi.org/10.5194/gchron-2-231-2020 (2020) ArArCALC – software for 40Ar/39Ar age calculations Intercalibration and age of the Alder Creek sanidine 40Ar/39Ar standard A test for systematic errors in 40Ar/39Ar geochronology through comparison with U/Pb analysis of a 1.1-Ga rhyolite A redetermination of the isotopic abundances of atmospheric Ar Re-evaluation of the ages of 40Ar/39Ar sanidine standards and supereruptions in the western US using a Noblesse multi-collector mass spectrometer Magnetic properties of oxidized (cation-deficient) titanomagnetites (Fe Arason, P. & Levi, S. Maximum likelihood solution for inclination-only data in paleomagnetism. Geophys. J. 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Cenozoic Volcanism in the Tyrrhenian Sea Region in Advances in Volcanology, pp. 399; https://doi.org/10.1007/978-3-319-42491-0 (Springer International Publishing 40Ar/39Ar constraints on some French landmark Late Pliocene to Early Pleistocene large mammalian paleofaunas: Paleoenvironmental and paleoecological implications Marra, F. et al. A review of the geologic sections and the faunal assemblages of Aurelian Mammal Age of Latium (Italy) in the light of a new chronostratigraphic framework. Quat. Sci. Rev. 181, 173–199. https://doi.org/10.1016/j.quascirev.2017.12.007 (2018) seismogenic structures and crustal stress field in the greater area of Rome (Central Italy) L’influenza dell’attività del Complesso vulcanico dei Colli Albani sullo sviluppo idrografico della Campagna Romana: l’alta valle del Fiume Sacco Volcanic activity and drainage network evolution of the Colli Albani area (Rome paleontological and 87Sr/86Sr isotope analyses of early Pleistocene paleoshorelines to define the uplift of Central Apennines (Italy) Villafranchian: the long story of a Plio-Pleistocene European large mammal biochronologic unit Tectonic-sedimentary evolution of intrapenninic basins and correlation with the volcano-tectonic activity in Central Italy Memorie Descrittive della Carta Geologica d’Italia 49 A major geodynamic change revealed by Quaternary stress patterns in the southern Apennines (Italy) New insights into the onset and evolution of the central Apennine extensional intermontane basins based on the tectonically active L’Aquila Basin (central Italy) Hominin responses to environmental changes during the Middle Pleistocene in central and southern Italy Nicoud, E. et al. Preliminary data from valle Giumentina pleistocene site (Abruzzo, Central Italy): a new approach to a clactonian and acheulian sequence. Quat. Int. 409, 182–194. https://doi.org/10.1016/j.quaint.2015.08.080 (2016) Download references The fieldwork in the Anagni basin has been carried out under the formal permission provided to the IIPU by the MIBACT—Ministero per i Beni e le Attività Culturali e per il Turismo Belle Arti e Paesaggio and by the Soprintendenza Archeologia Belle Arti e Paesaggio per le province di Frosinone The new NGX 600 mass spectrometer installed in November 2019 at the LSCE Facility and dedicated to 40Ar/39Ar geochronology was funded by a SESAME Ile de France grant to S Nomade as well as additional funding from the CNRS and CEA Saclay This research has been financially supported by the DTD-MIUR NextData project Drilling at Colle Marino was performed by C.N.G We thank Massimo Lenoci for technical support Istituto Nazionale di Geofisica e Vulcanologia Laboratoire des Sciences du Climat et de l’Environnement designed the archaeological study and performed stratigraphic investigations; A.P performed the 40Ar/39Ar age determinations; Fa.F. performed the sedimentological and biostratigraphic analysis All authors contributed to the writing of the text The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-021-85446-5 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Four years after the kick-off of the Leonardo Production System programme at Leonardo’s site in Anagni centre of excellence for rotor blades and composites in the helicopter sector it is possible to make an in-depth assessment of the initiative The Anagni site specialises in the production of rotor blades in composite material for all of Leonardo's helicopters has now become an indispensable management model for increasing safety at work on time and on cost”: according to Oreste Cafasso Head of the Centre of Excellence for Blades & Composite Rotor Heads for the Anagni and Yeovil sites these are the main objectives of the LPS programme achieved through the reduction of waste present in the processes and the active involvement and accountability of collaborators thereby increasing the safety standards and the environmental sustainability of the product The introduction of a production performance management model has led to a critical rethinking of the way of working and finding solutions on a day-to-day basis involving the entire organisation of the site The numbers of the change brought about by LPS are highlighted by Daniele Vincenzo Pagano and thanks to the active participation of about 70% of the organisation 50 workspaces have been launched that have involved all areas of the plant and have generated over 400 projects and 260 improvement proposals." The areas for improvement concerned all the site's activities from the manual and automatic processing of the pre-impregnated materials to the polymerisation processes through the chemical/mechanical treatments to finally the mechanical processing of the composite The design covered a wide range of activities from a single operation to the reorganisation of entire work areas and logistic processes "The LPS programme is comprised of ten technical pillars whose foundations are people and knowledge" "and in this context the Focused Improvement pillar aims to maximise the involvement of all company resources through the use of the tools made available by the LPS methodology seeking the optimal combination of project quality and quantity implementation times and related savings." The active participation of people is the real cornerstone of the Leonardo Production System it has involved over 230 people at the site so that everyone feels part of and responsible for the change “The LPS programme’s induction has allowed me to participate in the evolution of my workstation making it safer and more efficient,” notes Francesco Costantini With the results obtained from the LPS programme thus far The new objective of LPS in Anagni is to increase the reliability of the machines on the production lines "We will bring a planned maintenance system up to speed," explains Emanuele Di Girolamo "and then move on to more high-profile maintenance models such as condition-based maintenance (CBM) and predictive maintenance which are now a goal within reach.” The use of Artificial Intelligence allows for data-driven decision-making processes: site data is integrated to support the analysis and subsequent definition of any malfunctions "with a progressive reduction in maintenance costs thanks to the increase in skills and the involvement of our resources," concludes Di Girolamo Catalent is continuing to expand its fast-growing biologics operations agreeing to acquire Bristol-Myers Squibb (BMS)’s oral solid and sterile product manufacturing and packaging facility in Anagni Catalent will decide to continue to manufacture treatments for BMS but will also offer access to customers seeking a European facility offering sterile biologics fill/finish as well as oral solids manufacturing and packaging platforms Catalent says the Anagni plant complements its existing sterile fill/finish capabilities in Brussels and fill/finish capabilities in North America “The addition of the Anagni facility provides our European customers with great biologics and oral dose capabilities to accelerate their development programs and improve commercial supply,” Alessandro Maselli “Bristol-Myers Squibb has invested in the facility to create a center of excellence for new product launches with a robust quality and delivery record and an employee base who shares Catalent’s operational excellence and patient focus.” Opened in 1966, the Anagni facility manufactures and packages cardiovascular, neuroleptics, anticancer, metabolic, and anti-inflammatory medicines, as well as non-penicillin-based antibiotics, antivirals, analgesics as injectables, and biologics, according to BMS’ website The facility consists of approximately 19,300 square meters (207,743 square feet) of floor space on a site of 34 hectacres (84 acres) that is located in an industrial area 100 kilometers (62 miles) southeast of Rome Catalent and BMS said they anticipate completing their deal by the end of 2019 consultation with union representative of the plant’s employees and satisfaction of other customary closing conditions Catalent is a provider of advanced delivery technologies and development solutions for drugs Biologics continues to be a growth area for Catalent The company’s Biologics and Specialty Drug Delivery segment saw its earnings before interest and amortization (EBITDA) rise 38% year-over-year for the first three quarters of its current fiscal year 2019 to $119.1 million from $86.4 million in the year-ago period Revenue for the segment rose nearly 26% year-over-year to $511.1 million from $406.4 million in the nine months ending March 31 Biologics accounted for 28.5% of the $1.792 billion in total revenue Catalent reported for its 2019 fiscal year That’s up from 26% of the $2.463 billion in total revenue Catalent reported for its 2018 fiscal year—which was nearly double the 14% of FY 2017 “We’re still seeing strong growth in demand for development and production of proteins and monoclonal antibodies,” Michael A “We’re really trying to invest to get out in front of that demand That’s demand from current customers as well as the market in general.” a leading developer and manufacturer of viral vectors for $1.2 billion in a deal announced April 15 and completed May 20 said that the sale of the Anagni site marked an important step in the ongoing evolution of the pharma’s manufacturing network to support its innovative product portfolio “We believe that the sale to Catalent will continue the vital role the Anagni facility plays for its workforce “Bristol-Myers Squibb has a long history in Italy and we intend to maintain a continued strategic presence in Italy which is critical for our ability to deliver transformational medicines to patients.” Copyright © 2025 Sage Publications or its affiliates including those for text and data mining and training of large language models EMA’s committee for human medicines (CHMP) has approved an additional manufacturing site for the production of COVID-19 Vaccine Janssen the COVID-19 vaccine developed by Janssen-Cilag International NV The site will perform finished product manufacturing The site is expected to support the continued supply of COVID-19 Vaccine Janssen in the European Union This recommendation does not require a European Commission decision and the site can become operational immediately EMA press officeTel. +31 (0)88 781 8427E-mail: press@ema.europa.euFollow us on Twitter @EMA_News European Medicines AgencyDomenico Scarlattilaan 61083 HS AmsterdamThe Netherlands The contract drug maker is also expanding its gene therapy manufacturing thanks to growing business with Sarepta Therapeutics With rising demand for the two drug categories, the New Jersey-based pharmaceutical manufacturer confirmed it’s on track to achieve net revenues of $4.3 billion to $4.5 billion for FY2024 “Key factors underpinning our confidence include continued high demand for our gene therapy services expanded exposure to GLP-1 demand as we bring up more lines and a very strong rate of new approvals that we've seen in the pharma and consumer health segment in this calendar year,” Catalent President and CEO Alessandro Maselli said in the call Catalent plans to accelerate its investments in the diabetes and weight loss drug category at its existing sterile fill and finish facilities in Indiana and Italy. The company’s Bloomington facility produces Danish drugmaker Novo Nordisk's Wegovy by filling self-injection pens for the weight-loss drug, Reuters reported in August “We are now forecasting that a larger majority of our current and future pre-filled syringe capacity coming online in fiscal '24 through fiscal '26 is expected to be booked soon in support of this exciting category of products confirming our position as a leading CDMO in this space globally,” Maselli said Catalent is also growing its contract manufacturing for Sarepta Therapeutics. Catalent manufactures Elevidys for Sarepta, which won FDA approval in June as the first gene therapy to treat Duchenne Muscular Dystrophy Although the gene therapy failed to reach statistical significance during a clinical trial in October, Catalent is still optimistic about the therapy's potential for growth. “Sarepta has recently confirmed their scale-up plans for calendar 2024, firming up orders and we expect revenue from these top customers to grow approximately 65% this fiscal year as we manufacture product for the US market and the rest of the world to Sarepta and its partners,” Maselli said during the call. Get the free daily newsletter read by industry experts The aircraft maker accepted the Department of Justice’s agreement as crash victim families vehemently oppose it, calling it a “sweetheart deal.” The apparel maker focuses on technical and tailored garments, producing everything from Olympians' outfits to U.S. military gear. Subscribe to Manufacturing Dive for top news, trends & analysis Want to share a company announcement with your peers? The free newsletter covering the top industry headlines You don't have permission to access the page you requested. What is this page?The website you are visiting is protected.For security reasons this page cannot be displayed. for which it makes diabetes drug Wegovy.It was not immediately clear whether the expanded supply agreement would entail more filling work by Catalent at its Brussels plant or at a different site such as at Bloomington where it has the aseptic facilities needed to fill Wegovy pens.Knight said the expansion reassured that Catalent still has a good presence with Novo and removed what was probably one of the bigger concerns.The delay in its quarterly report triggered a delisting notice from New York Stock Exchange.Catalent cut its full-year revenue to a range of $4.25 billion to $4.35 billion from its prior forecast of $4.63 billion to $4.88 billion.It also slashed its annual adjusted net income forecast to between $187 million and $228 million from between $567 million and $648 million previously.Reporting by Bhanvi Satija Sriparna Roy and Pratik Jain in Bengaluru; Editing by Krishna Chandra Eluri Our Standards: The Thomson Reuters Trust Principles., opens new tab Bhanvi Satija reports on pharmaceutical companies and the healthcare industry in the United States. She has a postgraduate degree in International Journalism from City, University of London. , opens new tab Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts. , opens new tabScreen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. © 2025 Reuters. All rights reserved Catalent Biologics’ manufacturing facility in Anagni Italy will serve as the launch facility for the large-scale production and supply of the University of Oxford’s Covid-19 vaccine candidate Pharmaceutical product launch and packaging facility Catalent Biologics’ manufacturing facility in Anagni The company signed an agreement with AstraZeneca which is working with Oxford University on the development and production of AZD1222 The agreement will support the scale-up of capacity for the manufacturing of AZD1222 The facility will provide vial filling and packaging capabilities to AstraZeneca It will be ready for production by August 2020 and the company aims to deliver hundreds of millions of doses of the potential vaccine The production of the adenovirus vector-based vaccine will continue until March 2022 subject to the approval by regulatory authorities It will also accelerate the launches of customers’ biologics and oral drug products and broaden Catalent’s network in Europe Catalent plans to invest further in the facility for its growth The 28,000m² facility is a state-of-the-art pharmaceutical manufacturing facility located in an industrial area approximately 100km south-east of Rome Biologics fill-finish and oral solid dose product manufacturing and packaging centre was acquired from Bristol-Myers Squibb in January 2020 Bristol-Myers Squibb used the facility for technology transfers and accelerated launch of its various flagship products including Opdivo® (nivolumab) Sprycel® (dasatinib) and Reyataz® (atazanavir) The facility continues to manufacture Bristol-Myers Squibb’s products The manufacturing facility specialises in filling aseptic liquid and powder of biologics and sterile products in different vial sizes as well as primary and secondary commercial packaging solutions with blister and bottling capabilities for product launches Other capabilities of the facility include automated warehousing serialisation and a service that provides shipping of packaging solution within 48 hours after order placement The facility is approved by several agencies including the US Food and Drug Administration (FDA) Brazil National Health Surveillance Agency (ANVISA) Developed by the Jenner Institute at the University of Oxford and the Oxford Vaccine Group the recombinant adenovirus vaccine technology-based AZD1222 is backed by the US government AZD1222 utilises a replication-deficient chimpanzee viral vector derived from a weakened version of a common cold adenovirus that infects chimpanzees The vaccine contains SARS-CoV2 spike protein genetic material Vaccination will produce the surface spike protein and prepare the immune system of the patient to attack coronavirus if the body gets infected by it later It will be a single dose vaccine to create a strong immune response in individuals Vaccinated individuals will not suffer from ongoing infection as it does not replicate The drug is currently in clinical studies It entered Phase I / II clinical trial to evaluate the safety and efficacy of the drug in more than 1,000 healthy individuals aged between 18 and 55 years in southern England in April 2020 US Biomedical Advanced Research and Development Authority (BARDA) is supporting the vaccine development and production project with an investment of over $1bn The US Department of Health and Human Services (HHS) formed a partnership with AstraZeneca, under Operation Warp Speed, to deliver at least 300 million doses of Covid-19 vaccine AZD1222 by January 2021 First doses of the vaccine are expected to be available from October 2020 Phase 3 clinical studies of AZD1222 in Summer 2020 involve 30,000 volunteers in the US Catalent Biologics is a business division of Catalent a pharmaceutical company based in New Jersey focused on providing advanced delivery technologies and development solutions for biologics The company operates a network of facilities in Europe including Brussels including 2,400 scientists and technicians it signed an agreement with Arcturus Therapeutics to manufacture the LUNAR-COV19 vaccine candidate at its biomanufacturing facility in Madison The World Class Manufacturing (WCM) Association awards the Leonardo site in Anagni (Frosinone) for the improvement of production processes and programmes achieved through digital transformation and continuous attention to safety and the professional development of people It is a recognition for the four years in which all site workers have put their utmost effort into implementing the Leonardo Production System (LPS) programme The Leonardo Production System programme was born in the spring of 2019 with the aim of optimising the efficiency and productivity of Leonardo's industrial sites through a systemic approach oriented towards continuous improvement in the process and programme management and the achievement of increasingly higher levels of quality and safety This evolution required a rethink of the entire product lifecycle - movements up to the design and modeling of operational processes - while simultaneously increasing quality safety and sustainability of production performance it has favoured a change of pace in the involvement of all workers making them an integral and active part of the ongoing process also through professional retraining in line with the development towards a factory 4.0 model A path that first led to Leonardo's entry into the World Class Manufacturing Association in 2022 and then among the prizes awarded every year to the factories that have made the best progress in the WCM methodology WCM is the evolution and integration of methodologies and logics aimed at optimising production methods developed since the 1950s QRM (Quick Response Manufacturing) and TPM (Total Productive Maintenance) To these WCM adds the careful evaluation of losses and waste for the purpose of coherently prioritised and targeted planning (Cost Deployment) The activities of the teams involved in WCM are oriented towards carrying out Kaizen projects aimed at eliminating losses and their causes so as to achieve satisfaction among customers and stakeholders and The World Class Manufacturing Association is a non-profit organisation of different manufacturing companies that was founded to promote the development and implementation of best manufacturing practices; it also helps to increase the competitiveness of the production system for the benefit of participating companies The WCM Association encourages the exchange of knowledge between its various member companies acting as guarantor in identifying auditors to actively support the programme's development and granting “WCM Awards” to the best sites.  the World Class Manufacturing Association plaque was presented by Antonio Liotti Chief People and Organization Officer of Leonardo to Oreste Cafasso Head of CoE Blades Composite & Rotor Heads of Leonardo Helicopters,  in the presence of Manlio Cuccaro Services & Operations Officer of Leonardo EVP Manufacturing & Programme Management of Leonardo and head of the LPS programme SVP Industrial Operations of Leonardo Helicopters A notable result was also obtained in terms of management of the production machines with a reduction in maintenance costs of 30% in just 3 years This success is mainly attributable to the almost zero (-90%) of losses due to failure Labour-intensive work areas have seen a 30% improvement in productivity through the redesign of internal and external logistics flows as well as the implementation of low-cost automation systems to optimise operations A +25% was also recorded in the efficiency of machines and production systems thanks to the crucial role of people and their skills JSESSIONID - 4614F65A4B646E220AF2F579E8780990.lcsgepalsv146 BIGipServerPool-nuovo-sito-prod - 151654666.20480.0000 f5avraaaaaaaaaaaaaaaa_session_ - BCOOLDCIIANGOBIFNENAJNECPFAFEJIPINMCDILFCILPHLAFIDMHHPBBBNMBMILBGCDDJIGBCPBONACFPENACDNCALGLAMNJOHPBAKGCCCBJNBCJDJGLJIMKGJMCBHMB Dating back to the end of the 3rd century B.C. the Arcazzi di Piscina are two massive hemicycle-shaped travertine arches that support the walls of Anagni The use of the arch technique and the heavy stones in opus quadratum allow for equal weight distribution across the entire structure.  Although the true purpose of the structure is unknown or some type of defensive structure used to protect the city the Arcazzi was known as the “theatre” or the “swimming pool." This was due to their proximity to the ancient baths constructed by Fabius Valens It's believed the design was inspired by Hellenistic knowledge of fortification design.  Guests to the arches may spot a curious artifact located on one of the central pillars A phallic symbol carved from stone was crafted into the design of the structure phallic symbols were often used to ward off evil spirits.   Hours on Saturday: 9:30 a.m.- 1:00 p.m./ 3:00 p.m.- 5:30 p.m These hut foundations are believed to be the residence of Romulus Roman politician Herodes Atticus built this nymphaeum to honor his wife The ruins of this temple were later chosen by Pope Celestine V to found an abbey and a hermitage Alongside its 16th- and 17th-century architecture and interiors this mansion houses an Ancient Roman ring that some believe may have inspired J.R.R This ancient Roman aqueduct once funneled water to Diocletian's palace Ancient Phoenician and Roman tombs carved into the rock overlook the Moroccan coastline This beautifully situated lakeside Roman settlement was likely built during the reign of the Emperor Hadrian This ancient city was home to one of the greatest schools of Greek philosophy EMA’s human medicines committee (CHMP) has approved two additional manufacturing sites for the production of Comirnaty the COVID-19 vaccine developed by BioNTech and Pfizer Both sites will manufacture finished product These sites will produce up to 85 million additional doses to supply the EU in 2021 These recommendations do not require a European Commission decision and the sites can become operational immediately EMA is in continuous dialogue with all marketing authorisation holders of COVID-19 vaccines as they seek to expand their production capacity for the supply of vaccines The Agency provides guidance and advice on the evidence required to support and expedite applications to add new sites or increase the capacity of existing sites for the manufacture of high-quality COVID-19 vaccines The CHMP has approved a ready-to-use formulation of Comirnaty This formulation does not require dilution prior to administration will be available in a 10-vial (60 dose) pack size and can be stored at 2-8°C for up to 10 weeks The current concentrated formulation requires dilution prior to administration is available in a 195-vial (1,170 dose) pack size and can be stored at 2-8°C for up to one month) These differences will provide improved storage transport and logistic options for vaccine distribution and administration The new formulation will be available in a phased rollout starting in early 2022 The G7 Foreign Affairs Ministers, under the chairmanship of Deputy Prime Minister and Minister for Foreign Affairs and International Cooperation Antonio Tajani, met in Fiuggi and Anagni on 25 and 26 November and adopted a joint Statement Pictured: Facade of Novo Nordisk’s office in Fremont iStock, hapabapa Pictured: Novo Nordisk sign on building/iStock, hapabapa One of the biggest recent deals on the production side of pharma came Monday as Novo Holdings, the investment arm of the Novo Nordisk Foundation, announced it would acquire the contract manufacturer Catalent for $16.5 billion in cash The agreement involves the secondary sale of Catalent’s manufacturing sites in Bloomington the facilities will produce Novo Nordisk’s blockbuster GLP-1 drugs The deal itself is undoubtedly “unique” in the CDMO world the president of the Pharma & Biopharma Outsourcing Association (PBOA) a non-profit trade association representing CMOs and CDMOs in the biopharma industry “In an industry where the opposite tends to happen where larger pharma spin-outs manufacturing facilities But the deal comes following some turbulence for Catalent. Last year, the CDMO detailed that it was facing issues with productivity and costs at several of its facilities which led to the departures of its management personnel and Elliott Investment management taking a stake in the company an equity research analyst at RBC Capital Markets told BioSpace it wasn’t a surprise that Elliott was looking to sell the company as the investors’ goal was to sell it or break it up Dodge was surprised at the timeline of how this came about as he thought it would take a lot of time to get a deal together told BioSpace the deal reveals that there is not a large amount of capacity at least on the contract manufacturing side to handle the production of blockbuster GLP-1 drugs it makes sense to get as much production space as possible Smock noted that one of the more significant questions was what would happen to other customers who rely on those facilities to make other products Dodge speculated that contracts at other Catalent facilities are likely to be unaffected while contracts at the three facilities sold to Novo Nordisk will more than likely be in place for several years in a statement emailed to BioSpace from a Novo Nordisk spokesperson all 3,000 or so employees at the three sites will transfer to the company and Novo plans on honoring all current manufacturing contracts once the deal closes Eli Lilly CFO Anat Ashkenazi said on an earnings call this week that the pharmaceutical company which uses third-party manufacturing sources has questions about the Novo/Catalent deal and needs more information She noted that Catalent is an “integral part” of commercial and pipeline products and Lilly does have “products with these sites as well.” Ashkenazi said the focus will be on ensuring Lilly’s supply of medicine will continue but intends on “holding Catalent accountable for their contract with us.” Roth noted that the GLP-1 space presents many opportunities for contract manufacturers as more companies and modalities are coming online and will need manufacturing capabilities “There are a few instances where a drug takes off like this or drug class takes off like this; that’s going to demand a lot of capacity out there,” Roth said “You can contrast it with what happened with Operation Warp Speed how Moderna didn’t have much internal manufacturing capacity and used Lonza for bulk vaccines and other CMOs like Catalent and Grand River to make the vial version and they saw outsourcing as the way to pursue that.” Roth also said that on the back of this deal there could be another wave of consolidation or M&A activity and “significant capital investment” in CDMOs especially those with sterile fill-finish and prefilled syringe capabilities Smock also said he sees the Catalent/Novo deal as a “tailwind” for the CDMO industry noted that the agreement is a positive for contract manufacturers and validates the “strategic importance” they play in the drug supply chain Tyler Patchen is a staff writer at BioSpace. You can reach him at tyler.patchen@biospace.com. Follow him on LinkedIn 8): This story has been updated to note that Catalent is a member of PBOA You don't have permission to access the page you requested What is this page?The website you are visiting is protected.For security reasons this page cannot be displayed Missing the Carleton Arboretum Spring Bird count Pull out your binoculars and your birding checklists because Italian art has birds coming out the oiseaux For 2,000 years your fellow bird lovers have been depicting your favorite fowl in catacombs Below are some of my favorite birding spots in Italy Also in Anagni is the beautiful Crypt of St Look closely at the corners of the elaborate 13th century fresco cycles to spot some magpies Ravenna’s UNESCO sites are a prime place to see a multitude of bird species carefully rendered in Byzantine mosaic The Basilica di San Vitale in Ravenna contains an elaborate mosaic ceiling depicting birds from partridge to peafowl Also take a look up at the ceiling in the Cappella di Sant’Andrea to spot pheasants and guinea fowl The preserved frescoes in some of the Pompeian villas show delicately painted birds in garden scenes The Castel Sant’Angelo is one of Rome’s monumental landmarks perch under the gilded ceiling of one of the ornate halls Depictions of Noah’s Ark in church fresco cycles or mosaics is a good way to spot a variety of birds at once make an appearance on their way to board the ark These examples highlight only a small fraction of the birds I saw over my time in Italy The next time you visit a church or castle be sure to take a closer look to see if you can spot one of our feathered friends 507-222-4000 Sign In Students and staff from Bonifacio VIII Institute in Anagni visited Charleroi Area Middle School/High School Tuesday administrative coordinator of Bonifacio VIII Institute; Dr Charleroi Area High School principal; Francesca Arganelli vice president of Bonifacio VIII Institute Charleroi Area School District superintendent Students from Chareroi were paired with their Italian counterparts for a portion of the day spends time with Italian student Leonardo Campanello Charleroi Area High School/Middle School had some special visitors Tuesday A group of 38 students and four staff members from Bonifacio VIII Institute of Anagni a town in the hills east-southeast of Rome superintendent of the Charleroi Area School District “You could see it in their body language.” said Bonifacio VIII Institute students were paired with their counterparts from Charleroi Tuesday joining them for the first five periods of the class day just everyday American school,” Mason said The two teachers that came on the trip – a physical education teacher and a science teacher – spent time with those from Charleroi who teach those subjects vice president of the Bonifacio VIII Institute said the group arrived in the United States Oct “We teach a lot of subjects in English,” Arganelli explained “Most (of our students) are interested in having an experience abroad for the school year and for colleges We are very happy to be here and be welcomed here.” She added she hopes some Charleroi students will be willing to come to Italy to study While in Western Pennsylvania the group also plans to visit the Goodwill of Southwestern Pennsylvania store Duquesne University and Washington & Jefferson College and attempts are being made to schedule a trip to Ohiopyle Charleroi is the only high school on the itinerary Get Cappers Farmer Delivered Directly To Your Inbox Bonifacio staff and students will return to Charleroi Friday afternoon they will attend Charleroi’s football game against Washington “It’s a win-win,” Zelich said of the visit I really think it’s going to leave an indelible mark on our students and our staff.” If you have an account and are registered for online access sign in with your email address and password below Never been a subscriber and want to subscribe Copyright © Observer-Reporter | Contact | Terms of Use | Privacy Policy Catalent will retain all 700 staff and invest up to $10 million into a site in Italy it is acquiring from Bristol-Myers Squibb will see the contract development and manufacturing organization expand its biologics network outside of the US through the addition of a sterile product manufacturing and packaging facility in Anagni Financial details regarding Catalent’s first biologics manufacturing facility in Europe have not been divulged but a spokesperson told this publication the CDMO intends to expand the site further Italy plant will be acquired by CDMO Catalent “Catalent is planning to invest a further $5-$10 million in the site’s growth on top of significant recent investments by Bristol-Myers Squibb Catalent is not disclosing further details of these investments at this time and cannot until the deal closes.” The transaction is expected to close by the end of 2019 brings Catalent’s biologics customers access to sterile drug product fill/finish and packaging capacity in Europe “The site’s capabilities include sterile vial and powder filling new product launches and biologics and small molecule packaging including dedicated suites with containment capabilities appropriate for aseptic fill/finish and capabilities in sterile vial and powder filling,” the spokesperson said “The Anagni facility provides customers with access to a world-class team and facility for late-stage development programs In addition to the host of oral dose manufacturing capabilities and turnkey packaging solutions including robust serialization onboarding processes and capabilities at the site Anagni adds vial capabilities to Catalent’s existing drug product fill/finish offering for biologic programs in Europe.” One of the plant’s customers will be former owner Bristol-Myers Squibb (BMS) as under terms of the deal Catalent will continue to manufacture the Big Biopharma’s products from the site Catalent will also retain all 700 employees at the facility Traditionally a small molecule encapsulating services firm Catalent has invested heavily in its biologics offerings over the past decade adding an 875,000 square foot development and manufacturing facility in Bloomington Most recently the firm entered the gene therapy space through the $1.2 billion acquisition of Paragon Bioservices the CDMO now estimates biologics will jump from roughly 26% of its total business to 31% and as customer demand in the space grows and new capabilities come online the large molecule business mix will push towards 50% of overall revenues Journalist covering the international biopharmaceutical manufacturing and processing industries.Founder and editor of Bioprocess Insider a daily news offshoot of publication Bioprocess International with expertise in the pharmaceutical and healthcare sectors regulatory affairs and business development.From London UK originally but currently based in Montpellier France through a round-a-bout adventure that has seen me live and work in Leeds (UK) CSL Seqirus signs pandemic preparedness plan with European Commission Ins & Outs: Biopharma players shuffle c-suite ranks American made: Companies continue to emphasize US manufacturing Transforming Protein Production: Lonza’s Comprehensive Solutions for Therapeutic Innovation Registered in England & Wales with number 01835199 This story was updated to add new information The parent company of Danish drug maker Novo Nordisk said it completed its $16.5 billion purchase of Catalent including the Bloomington operations on Wednesday Novo Holdings, the Denmark-based parent company of Novo Nordisk, announced the deal in January and said last weekend it had cleared “all regulatory closing conditions” and the parties “are now free to close the transaction.” Novo Nordisk plans to buy from the holding company three sites — Brussels; Anagni Italy; and Bloomington — for $11.7 billion Some Bloomington employees have expressed concerns on social media, but George Telthorst, director of the Center for the Business of Life Sciences at Indiana University's Kelley School of Business said Tuesday he still expects the deal to benefit local employees and the community “Demand for GLP-1 drugs (like Wegovy and Ozempic) is strong and studies are underway for their use on other conditions besides diabetes and weight-loss,” he said via email “This will provide the local plant with growing demand for its production and support its long-term operation “Indications are that Novo will be investing in both the plant and the community,” Telthorst said A company spokeswoman did not answer questions about whether Novo Nordisk planned to cut jobs but said via email the 3,500 employees at the three sites are “highly skilled” and all will transfer to Novo Nordisk “They have valuable capabilities and insights into fill/finish manufacturing and will play a key role in Novo Nordisk’s aim to serve even more patients,” said Jamie Bennett director of media relations and issues management for the U.S The company could not immediately say how many people work at each location though data on the website indicates Bloomington is the biggest site by far The site lists Brussels with more than 500 employees Anagni with more than 1,000 and Bloomington with more than 2,400 Telthorst also has said the company has an unusual ownership structure — it is owned by a foundation — and also has altruistic goals unlike a traditional corporation that aims to primarily create shareholder value Catalent shares in January spiked on news of the planned acquisition to near $60 Catalent says on its website that the Bloomington campus includes five facilities for drug manufacturing The company expanded its Bloomington operations with more than $100 million in investments and an additional 1,300 employees in 2020 to increase production of COVID-19 vaccines the company added 1,000 more employees in Bloomington and raised its starting wage to $19 per hour It cut jobs as demand for the COVID-19 vaccines waned The company said in March that it would cut 130 jobs in Bloomington Some federal lawmakers and competitors expressed concerns about the deal. U.S. Sen. Elizabeth Warren, D-Mass., wrote to the Federal Trade Commission in October that she worried the deal would lower competition and increase prices. However, European regulators approved the deal “unconditionally” on Dec. 5, and Novo Holdings’ announcement from Dec. 14 indicates the FTC will not try to block the deal either. Boris Ladwig can be reached at bladwig@heraldt.com. which uses the same ingredient as its diabetes drug Ozempic.Novo Nordisk which was overwhelmed by demand for Wegovy after it was launched in the United States in 2021 said on Thursday that a second contract manufacturer was ready to begin production of the drug.It was not immediately clear if Wegovy was made at any of Catalent's impacted facilities Novo Nordisk was not immediately available for comment outside of business hours.Catalent on Friday also named company insider Ricky Hopson as interim CFO and said it had launched the search for a permanent finance chief.Reporting by Manas Mishra in Bengaluru; Editing by Shounak Dasgupta Connecting decision makers to a dynamic network of information Bloomberg quickly and accurately delivers business and financial information according to people with knowledge of the matter The financing — one of the largest private credit transactions on record — will help fund the $16.5 billion acquisition of Catalent by Novo Holdings, the controlling shareholder of weight loss drugmaker Novo Nordisk A/S The package is made up of a $4.2 billion term loan and $575 million revolving line Looking to access paid articles across multiple policy topics Interested in policy insights for EU professional organisations ICC warrants not mentioned in final G7 Foreign Ministers communiqué either observed and verified directly by the reporter or reported and verified from knowledgeable sources concluded with a strong call for an immediate ceasefire and welcomed diplomatic efforts to find a solution (AP Photo/Gregorio Borgia) Pope Francis presides over vespers of the Feast of St. Mary and Te Deum of Thanksgiving at year's end, in St. Peter's Basilica at the Vatican, Tuesday, Dec. 31, 2019. Vatican City • Sometimes even the pope has to apologize for being grumpy. On Wednesday, Pope Francis kick-started the new year with an apology for slapping the hand of a woman who grabbed his arm in St. Peter’s Square the night before. “Love makes us patient,” Pope Francis told faithful gathered to celebrate the feast of the Solemnity of Mary and the 53rd World Day of Peace. “We often lose our patience,” he said. “Me, too, and I apologize for the bad example I set yesterday.” While walking amid the crowds near the Nativity scene in St. Peter’s Square on Tuesday night, Francis reached his hands to greet faithful and children. One woman grabbed his hand, causing him to lose his balance. Visibly irritated, the pope slapped the hand of the woman twice with his left hand before walking away. The images of the papal slap made the rounds on the internet and especially social media. Where one stands regarding Francis plays no small part in whether his act is interpreted as “angry” or “righteous.” And he's not the first pope to take part in a controversial slap. In September 1303, Pope Boniface VIII was slapped by an envoy from Prince Philip of France in the small town of Anagni, just outside of Rome. (There's some question over whether the envoy actually slapped the pope in the face.) Boniface had been working to reduce the influence that Philip had on the Catholic Church. So Boniface issued a papal document, asserting that the pontiff had absolute power and supremacy over kings of earthly realms. For the pope’s admirers and courtesans, who included the famed painter Giotto, this was a sound and essential move. But for his foes, who included the poet Dante Alighieri, such an offense merited a very specific place in hell — the eighth circle, to be exact. Philip was not thrilled by the papal document. In a move known as the Slap of Anagni, or the Outrage of Anagni, Philip's envoy took Boniface prisoner, then had him tortured and beaten for a few days. He was released after the local populace objected and he died a month later, paving the way for the French dominion over the papacy. In the past, slaps were part of Catholic rituals. Young men becoming priests were lightly slapped by their bishop as were young people who were being confirmed. The practice has been largely abandoned, for the most part because it was misunderstood. Thanks to video and social media, there is no doubt concerning the details of Pope Francis’ New Year's slap, which was captured on video. The response was mixed. For Italian right-wing populist Matteo Salvini, the event offered a special opportunity to target and make fun of the pontiff, who has been an opposition force for Salvini's anti-migration policies. For many women, Francis’ slap took on another dimension. Francis has condemned violence against women and in a speech on Tuesday spoke of victims of abuse who are “continually offended, beaten, raped, forced into prostitution.” He also spoke in support of giving women more leadership and influence. These words strongly clashed with the widely distributed images showing Francis slapping a woman, twice. Wednesday was also not the first time a pope apologized publicly for something. Throughout his pontificate, St. John Paul II apologized for the Catholic Church’s role in the African slave trade, the deaths of Muslims during the Crusades, the Holocaust and the Inquisition. His successors, Benedict XVI and Francis, have apologized repeatedly for the clerical sex abuse crisis. In apologizing Wednesday, Pope Francis spoke about “stepping down from the soapboxes of our pride." “So that the year that begins will be a journey of hope and peace, not in words, but in daily actions of dialogue, reconciliation and the care for creation.” For e-edition questions or comments, contact customer support 801-237-2900 or email subscribe@sltrib.com sltrib.com © 1996-2025 The Salt Lake Tribune. All rights reserved. like two old friends you haven’t seen in a while Before you is a stone country house surrounded by olive trees and flora The hosts motion for you to follow them inside the wide and deep hall furnished with a mix of classical and contemporary elements: wooden ceiling coffer sofas that convey a sense of relax just by looking at them Natural light filters through the white linen curtains adorning the large windows giving the room an ambiance of impalpable freshness you have a glass of Prosecco in your hand and you’re cheering with Joe and Alana in the natural rock cellar Everything around you vibrates with a sparkling and genuine energy.  Describing the beauty of this luxury holiday farm is a feat every detail seems to have been created to be exactly where it is a combination of different origins with one common thread: the people who chose them.  Alana and Joe’s life is an adventurous tapestry that starts 30 years ago Joe was a successful hairdresser in Yorkshire but with Sicilian origins Alana was the commercial director of an important company in London she went to one of Joe’s hair salons to get a haircut they realized that their hectic lifestyle was no longer for them almost in the shape of the original structure of the farm dating back to 1300 Inside was a restaurant managed by a local couple who could no longer take care of it In a short time they repurposed the Casale turning it into the marvelous temple to wellness that it is today each named after the genuine surroundings: Bel Fiore (beautiful flower) Bella Vista (beautiful view — the name guarantees!) Each room has its own balcony facing the steep hill and Anagni in the distance a patio with a charming fountain and a wonderful wooden bench that is Alana’s favorite spot to an outdoor sitting room with a breathtaking view of the surrounding scenery which is Joe’s favorite spot and you know things will position themselves to help you You need to entrust yourself to fate and believe,” says Alana looking in your eyes with a light in hers that tells how incredible this experience has been for her rosé wine “Caterina,” named after the producer from a nearby area and extraordinary oil produced here at the Casale that I was leaving to start a new life chapter I would’ve expected anything except that he would also exclaim that he wanted a fresh start too Sometimes it’s not easy to balance family and career the real mission is to be an example for other women looking for inspiration who want to find the strength to change their life.” but also wedding receptions and adrenaline-filled activities like zip-lining or rafting.  The visit to Casale San Pietro is coming to an end you listen to the sound of water coming from the fountain (water and natural light are the key elements of the Casale) and you let yourself wonder once again at the sense of refined beauty and peace that have surrounded you ever since you arrived here You watch Alana and Joe in the distance as they clean the table where you ate lunch together comes to mind: “We delight in the beauty of the butterfly but rarely admit the changes it has gone through to achieve that beauty.” Your head is still full of their beautiful story and you can’t help but be a little bit brave like them what is your secret?” Joe answers sweetly: “Taking things slow the last thing you notice is a hatrack by the door “Do you know that song by Paul Young that goes They leave their hats because they know they’ll come back.” Contacts392 6480075casalespietro.com facebook.com/CasaleSPietro By subscribing you agree with our privacy policy Check your inbox or spam folder to confirm your subscription Sign up to our newsletter for the latest news Slide 2Learn To Make Gelato in an Authentic Roman Gelateria Slide 6Colosseum Walking Tour with Roman Forum & Palatine Hill artisan tourThe Artisan Walking Tour in Monteverde Slide 5Enjoy the Eternal City on a Vespa or Sidecar Check out all the TOURS and local EXPERIENCES This insider guide on how to live like a local is the main event and lifestyle magazine devoted to Rome and written entirely in English Romeing is a magazine for tourists and expats visiting or living in Rome including an event calendar and feature articles written by locals with secret insight for your vacation or for those considering moving to live in Italy with a daily listing of the latest and most diverse cultural and lifestyle events in and around Rome This is an essential information tool that allows foreigners of every age and background to live Rome to the fullest and discover the top things to see and to do in Rome Construction of an extrusion system in Anagni for 15,000 tonnes of rPET a year The global manufacturer of plastic packaging and recycling specialist is investing more than five million euros in an extrusion system for food-grade recycled PET (rPET) made of used PET bottles (so-called post-consumer material) at its site in Anagni Anagni in central Italy is home to one of the Alpla Group’s most important preform production plants processes around 50,000 tonnes of PET a year of which only a very small proportion is recycled material as of today But in future a substantial portion of the volume required is henceforth to be supplied in the form of recycled material giving customers the option of sourcing preforms made partly or even entirely of rPET Alpla is installing an extrusion system for 15,000 tonnes of rPET a year at the existing business premises The investment sum for construction of the building needed and for the system totals more than five million euros It is scheduled to go into operation in the second half of 2021 “We will buy in PET flakes made from used household packaging from local recyclers process them into food-grade rPET and then use this at the site for preforms,” says Fabio Mazzarella production of the recycled material right there in the processing operations results in attractive synergies in logistics and warehousing and potentially also energy considers the investment in central Italy to be a foresighted strategic decision: “We want to promote the bottle-to-bottle cycle and avoid downcycling we would like to boost local recycling solutions in a region that does not have the necessary infrastructure for the bottle loop up to now’ the recycling expert explains The demand for recycled material can currently be managed well we are ensuring that we can offer our customers optimum support with realising new specifications and targets in the long term too and that we can offer them top-quality recycled materials.” italy all images courtesy of nabito architects spain and italy-based practice nabito architects has shared with us images of ‘landscape infrastructure’ a multi-level mixed-use building in anagni situated on the boundary between the city and the local countryside the design inserts itself into the landscape to secure views of the valle del sacco while serving as a functional and spatial mediator between the two diverging characters of the site read as an overlapping composition of four pentagonal volumes the design opens up to the south side of the sloping plot with the back of the building retaining the soil of the plot multiple terraced roofs and gardens extend out of the topography to dissolve the distinction between architecture and land an open plaza space connects the buildings together with a fluid circulation while providing a public platform for meeting and interaction conceived with a focus on sustainable design the project utilizes solar orientation for natural daylighting and cross ventilation with local stones and travertine for flooring AXOR presents three bathroom concepts that are not merely places of function but destinations in themselves — sanctuaries of style Please view the main text area of the page by skipping the main menu. 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