Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here Infrastructure and Energy Economics Consultant Lisa conducts policy-oriented research in the sectors of energy and water and sanitation at the Inter-American Development Bank (IDB) Her work focuses on informing policy makers on pressing infrastructure challenges in Latin America and the Caribbean including access to infrastructure services and enhancing resilience against the effects of climate change she worked with the Middle East and North Africa Transport Unit at the World Bank where she mainly focused on transport policy Lisa holds a PhD in economics from the Université libre de Bruxelles and is an associate fellow at the European Center for Advanced Research in Economics and Statistics (ECARES) the entire area is changing face with the first demolitions of the buildings and with the start of land and sea reclamation" The control room on Bagnoli looks like a turning point: “For Bagnoli – explains the mayor of Naples and government commissioner for the ex Italsider area to 'Mattino' Gaetano Manfredi – it is a very important step forward: the sea reclamation project has been accepted now we have all the authorizations for the reclamation of the sea We expect to start by the end of the year at the latest It will take about 3 years to complete the reclamation has already all started: all the works are financed including those for the infrastructures After decades of waiting – he continues – the entire area is changing face with the first demolitions of the buildings and with the start of the reclamation on land and at sea The goal is to return Bagnoli to the territory and to all Neapolitans to finally be able to use it with the beaches Prime Minister Giorgia Meloni signed the Pact for Bagnoli worth 1,2 billion Today she was not present in the Control Room but she met with her: “We exchanged some opinions With the Control Room we are continuing the virtuous institutional path started with the government the decisive step forward that we have taken for the redevelopment and redevelopment of the Bagnoli area is being formalized” Regardless of the political and administrative data people really want to see what is happening inside that site they want to see first-hand the progress that is being made: "There are new elements I'm thinking of the temporary uses of the site: we are already using the Porta del Parco and the Auditorium We are working on the redevelopment of the North Pier - which according to the plan was supposed to be demolished - and on the landfill to have a more intensive use of these two sites" we would like to make the best use of the Pier which will become a place for seaside walks and for sports And the landfill that will no longer be demolished In Bagnoli there is the sea but no port: "A collaboration agreement has been signed between the extraordinary commissioner the Port System Authority and Invitalia for the evaluation of the project financing proposal presented by a group of companies The goal is to organize the area with a series of docks The opportunity to regularize the authorizations in an area where there is a lot of confusion There will be a main dock with nine arms and yachts up to 30 meters will be able to dock there The essence is that with the Control Room the green light has been given to all the corrective measures of the Bagnoli Plan On industrial archaeology "we will proceed with the safety measures starting from the former steelworks Then we will carry out a scouting operation to find both public and private resources which is installing a laboratory in the 'three glasses' and will be ready by the end of the year The restoration and expansion works of the aquaculture plants of the '6 glasses' building have begun and their completion is expected within the first half of 2026 and therefore by the end of the year the Center will be operational and functioning" The former steelworks is planned to house the Naples conference center: "The idea is that the steelworks could become a conference center for us it would be the most appropriate use We expect investors to be interested in our proposal,” concludes Manfredi Read also other news on Nova News Click here and receive updates on WhatsApp Follow us on the social channels of Nova News on Twitter, LinkedIn, Instagram, Telegram has resigned following disagreements with the institute’s general manager had taken office at the helm of the Carrara on Feb after experience at the Gallerie Estensi in Modena and Ferrara and had replaced Maria Cristina Rodeschini relations with the general manager were stormy and nothing the city council and the museum’s board of directors could do to try to sew the rift: in particular the extraordinary board of directors of the Fondazione Accademia Carrara tried to find a solution to avoid Bagnoli’s farewell Bagnoli’s experience thus lasted just eight months.The case came to public attention only a few days ago and even today it is still being discussed practically only in Bergamo and its environs has dealt little or nothing with an affair that has therefore held court almost exclusively in local newspapers there had been no shortage of signs of the now former director’s impatience: above all the article she wrote last October 7 in the daily newspaper Domani in which Bagnoli lashed out against “cultural managers,” writing that “at the head of the great international institutions there are professionals with years of experience in the sector,” while “in Italy different profiles are favored and the mentality is corporatist.” “To run museums,” Bagnoli continued “’culture managers’ are invoked because museums are ’companies’ and must be run by people who know how to make ends meet People who have little experience of museums little familiarity with the collections they are supposed to care for little affinity with the research they are supposed to promote and above all no understanding of the difficult balance between reputation and marketing are often called upon to manage important Italian institutions based on varied curricula in very different fields: from journalism to public relations from academia to television.” For Bagnoli art historians should be in charge of museums “because to get there they have worked for years in other museums: they are thus appears to be a succession of jabs at Bonaldi “There has been a lack of transparency and trust,” Bagnoli wrote in her letter of resignation according to the director there was “an imbalance on the position of the general manager that is in fact no longer a duality This was not transparent at the beginning and therefore created disagreements.” who is also president of the Fondazione Accademia Carrara in an interview with theEco di Bergamo let it be known what proposal the board of directors tried to put forward to mend the rift: a proposal “that would shed light on the respective attributions of responsibility and operations starting with acquisitions of works and collaborative projects of an artistic order and on cultural content to enhance the museum’s identity and the communication of exhibitions.” The “effort made in recent weeks,” Carnevali continued “which we think has not been understood or not wanted to be grasped has gone in the direction of making clarity in their respective responsibilities.” the Carrara Academy’s organizational structure provides for a kind of dual leadership: the director and general manager are in charge Both are appointed by the board of directors at the proposal of the president and both have terms of office set by the board of directors The director is in charge of tasks concerning conservation enhancement and planning of cultural activities (so he or she prepares the program on conservation promotes quality standards for the management of educational activities proposes loans of works for national and international exhibitions while the general manager has overall responsibility for the management of the Foundation (thus fundraising and museum development projects submits budget proposals to the board of directors takes measures to improve functionality and efficiency enters into purchase contracts for goods and services the general manager manager managerial and administrative duties According to the Bergamasque edition of the Corriere della Sera reportedly made a counterproposal to the foundation’s board of directors to redefine the responsibilities of the two roles has given her willingness to continue working on the scientific projects already underway particularly the Autentic and Copy exhibition the Foundation will have to look for a new director Thanks for visiting Link IconCopy linkFacebook LogoShare on FacebookXShare on XEmailShare via EmailLink copied to clipboardPenn extends win streak over Colgate in a rainy home openerThe win over Colgate extended a six-game winning streak for the Quakers in the annual nonconference clash the Penn football team showed some of its potential by putting a scare into perenially tough Delaware The Quakers took it up a notch Saturday in their home-opening 27-17 win over Colgate the Quakers showed more than a flash against Colgate taking a 27-17 win in their home opener at Franklin Field The victory extended a six-game winning streak for the Quakers in the matchup scoring the first 14 points of the game and took a 21-7 lead into halftime Penn’s offense would sputter in the second half scoring just a pair of field goals in a driving rain at Franklin Field » READ MORE: Meet Penn's ace in the hole on the gridiron, sophomore running back Malachi Hosley We worked hard this week,” coach Ray Priore said “I thought we took the next step as a football team.” former coach Al Bagnoli was honored for his recent induction into the Penn Athletics Hall of Fame Bagnoli is the winningest coach in Penn football history (148-80) and led the team to nine Ivy League championships Bagnoli walked out to midfield as an honorary captain for the coin toss Priore served as an assistant coach for Bagnoli’s entire 23-year tenure at Penn before taking on the role himself Penn’s offense used sophomore running back Malachi Hosley conservatively to start the game before letting him loose after halftime Hosley ended his day with 131 rushing yards and 21 through the air This marks the first time since 2003 that Penn has had a rusher gain 100 yards in five consecutive games Senior quarterback Aidan Sayin ended his day with zero turnovers after he threw a costly interception to end the game last week “It’s huge to not turn the ball over,” Sayin said so just keep working on that every week in practice.” Sayin found his favorite target in 6-foot-2 junior wideout Jared Richardson on a 36-yard go route Richardson climbed the ladder over sophomore defensive back Tymir Win for six; Richardson let the Colgate sideline hear it gesturing that the 6-foot Win was “too small.” “They were talking a little bit,” said Richardson who finished with six receptions for 96 yards Although Penn didn’t find the end zone after halftime keeping the Quakers in the driver’s seat for the remainder of the game He ended his day with 320 passing yards and three touchdowns Colgate employed a three-quarterback attack there were two: junior Zach Osborne and sophomore Jake Stearney which produced 83 yards and a missed field goal attempt. Osborne took a designed quarterback run for 31 yards to the end zone for the Raiders’ first points on the day hitting junior wide receiver Brady Hutchinson on a 3-yard touchdown pass “Every quarterback and part of the system had a uniqueness to it,” said Priore who now will prepare the Quakers for its Ivy League opener Saturday at Dartmouth (1 p.m. » READ MORE: Follow the Inquirer's full coverage of Penn athletics right here! In case you needed photographic evidence… 📸#FightOnPenn x #BEGREAT pic.twitter.com/GLJ52lVotx [The following video is available in Italian only] I believe the Mayor said a lot about what we are here to do today and I think his words have made it clear that something very important is happening this morning for Naples You of course all know the history of this area better than I do about what happened here in Bagnoli after the hot rolling mill was closed on 20 October 1990 followed by the definitive closure in 1993 of what had been one of Europe’s largest industrial areas and steelworks for almost a century: Ilva-Italsider in Bagnoli which made its mark on the history of manufacturing in the South the jobs it created for generations of workers and the contribution it guaranteed to economic growth in the Mezzogiorno one of environmental clean-up and regeneration of the area the aim of which was to give back to citizens an incredibly vast area spanning 250 hectares of land and 14 square kilometres of sea You also know better than I do that this did not happen all attempts at redevelopment did not achieve the results that were hoped for and judging by the slogans I’d say they were from social centres if they were from other groups or committees for instance then I would like to tell those citizens talking about politicians just parading around that I understand them because many promises have been made here that have not then been kept I would also like to tell those citizens to give us the chance to show that things can change we saw the resounding failure of Bagnoli Futura which should have carried out the redevelopment work but instead left behind a site that is 93% contaminated keeping the environmental disaster of the landfill at sea substantially unchanged with almost 200 thousand square metres filled with concrete and polluting waste from the former Italsider plant’s blast furnace Bagnoli Futura went bankrupt ten years ago and the area has been put under a special commissioner; the first government commissioner was appointed in 2015 and Invitalia was named as the implementing body for the clean-up programme an important element was missing to ensure the special commissioner could deliver concrete results: resources That is the problem we are now trying to help solve and it is a problem we have been working on ever since we came to office we have relaunched the steering committee provided for by law which has established the Bagnoli-Coroglio crisis area the environmental clean-up and urban regeneration plan (the so-called ‘PRARU’) has been revised and we have above all dealt with finding the resources needed to ensure that commitments undertaken do not remain unlike what has happened for so many years It is worth remembering that approximately EUR 2.28 billion is needed to cover the cost of clean-up and redevelopment work on this site whereas only EUR 480 million had been made available corresponding to less than a seventh of the necessary amount we therefore decided to allocate what was needed to cover public investments EUR 1.218 billion from the Development and Cohesion Fund resources for 2021-2027 The Cohesion Decree allocates these resources and provides for a memorandum of understanding to be signed that sets concrete goals and are here in Bagnoli and are deciding to take responsibility for a long-standing problem one of those issues that have been going on for so long that citizens at a certain point become convinced that nothing can be done to reverse the trend believe that real politics must be about testing our abilities on difficult goals but above all it is the only way to bring citizens closer to the institutions again We are trying to do this also in this region I can see Commissioner Ciciliano and Caivano comes to mind where it was also said that nothing could change of course together with all the authorities and institutions involved the institutions want to take on a commitment I therefore wish to thank Minister Fitto together with Mayor of Naples and Government commissioner Manfredi I also wish to thank all administrations that have been working on this objective for several months because this involved great teamwork which has effectively created the conditions to finally tackle the environmental clean-up work and the most ambitious urban regeneration project in Europe the memorandum of understanding we are signing today provides for all the measures included in the clean-up programme to be sped up starting with full remediation of the soil and marine area and network and infrastructure reconstruction and strengthening it also sets a number of new goals: I am thinking of the construction of a 2km-long waterfront making it possible to swim along this stretch of coastline; I am thinking of the redevelopment of Borgo Coroglio; I am thinking of the urban park covering 130 hectares complete with sports facilities and industrial archaeological sites; I am thinking of the 13km of cycle routes; I am thinking of the 8 gigawatt hours of solar energy produced; the construction of new buildings and of course the renovation of existing ones This package of measures must be completed by 2031 and there will be the knock-on effect of more than 10,000 jobs being created upon completion of the work to clean up the asbestos contamination construction sites will be opened to begin rolling out the first measures abandoned area which had come to symbolise a failure by the institutions to manage to be concrete in their responses seaside tourism and commercial hub that lives up to the extraordinary city of Naples build and work together on this strategic project thanks to the cohesion policy reform carried out by this Government Said reform takes its inspiration from a very precise vision which is to use all the resources necessary to overcome regional gaps focusing those resources on strategic projects and major investments These resources are extremely valuable but they have not always been spent or used for strategic measures Completing the clean-up of Bagnoli is a strategic investment I am proud of this Government’s choice to allocate EUR 1.218 billion in cohesion resources to this project However - and you’ll excuse me for zooming out a little as everything works as part of a strategy - the cohesion policy reform that gave rise to the cohesion agreements we have signed with 18 Regions and Autonomous Provinces so far is only part of the overall strategy we are trying to envisage for Italy’s Mezzogiorno we also established an ‘infrastructure equalisation’ fund and made it a legal requirement to allocate 40% of resources to infrastructure in the south of the country I consider this to be an important response because for years spending on infrastructure had been distributed based on population distribution but continuing to use this parameter alone won’t work because we have a problem with depopulation in the south of Italy and that depopulation is linked to the lack of opportunities and the lack of opportunities is linked to the lack of infrastructure it therefore won’t be possible to address this issue in a more structured and structural way.  I also wish to recall that we dealt with employment in the Cohesion Decree too allocating approximately EUR 2.8 billion to support the hiring of women young people and disadvantaged individuals then they won’t have to pay the related contributions to the State on one condition: that those people are hired on a permanent basis I also have some good news regarding an extension of the ‘Decontribuzione Sud’ measure [an aid scheme for the South] which has been praised across the board by all political groups This was granted by the European Commission at the Italian Government’s request This is obviously an extremely important measure which we believe is very useful and are working to make it structural in nature Minister Fitto has already begun work with the European Commission on this goal and I am very confident he will succeed in this too Then there is the single SEZ for the Mezzogiorno which I believe to be another very important measure as it allows investments in Italy’s eight southern regions to benefit from streamlined administrative procedures and tax breaks This makes it more profitable to invest in these regions the tax credit we have already invested EUR 2 billion in and that has recently come into force offers an advantage for those investing in these areas I therefore wish to say that I very much believe in this measure and am convinced it will guarantee more development more employment and an overall improvement in the quality of public services I think this is substantially what the Mezzogiorno needs: tools to allow it to compete on an equal footing and prove its value and worth and we have based our measures precisely on this view of Italy’s South We have put in place a package of measures that will also help consolidate and strengthen the Mezzogiorno’s economy and GDP in the south of the country grew by approximately half a point more than the national average The number of new jobs in the Mezzogiorno increased by 2.6% compared with a national average of 1.8% the figure I am most proud of regards the amount of investments in public works projects and strategic infrastructure up from EUR 8.7 billion in 2022 to EUR 13 billion in 2023 ‘Citizenship infrastructure’: the basis for building equal rights and equal opportunities for citizens in this region.  I would therefore like to thank Minister Musumeci also for coordinating the decree law regarding the Campi Flegrei [Phlegraean Fields] which allocates EUR 400 million to combat the phenomenon of bradyseism I also wish to thank Minister Fitto for the EUR 388 million that the most recent resolution by the Interministerial Committee for Economic Planning and Sustainable Development (CIPESS) allocated to this area to allow projects from the previous European programming period to be completed meaning resources to help municipalities fully implement those measures I would also like to thank Minister Sangiuliano who is also here; of course being from Naples he has focused a lot on highlighting this city’s distinctive characteristics and identity I also wish to once again thank the Mayor of Naples because we are working together on many projects the most important of which is undoubtedly the creation of Europe’s largest example of cultural infrastructure in the former Real Albergo dei Poveri in Naples the aim is to give the city back a huge space which will host a branch of the National Archaeological Museum of Naples a library and a campus of the University of Naples Federico II excuse me for taking this opportunity to also provide a comprehensive overview of what we are doing not just for the Campania Region but for the Mezzogiorno as a whole There is clearly still a lot of work to do in the end we are finding the resources for serious things The outlook before us is a medium and long-term one allowing us to plan and schedule actions and We will therefore do what needs to be done and we will show those who thought these areas were somehow beyond saving to keep them in their current condition with an over-reliance on welfare benefits well we will show those people that they were very much mistaken Much more can be done and done differently and it is possible to put these areas in a position to be able to compete on an equal footing and prove their worth Certified email addresses (PEC) Email addresses Tim Murphy and Buddy Teevens in your head.  You probably see them working their magic on a football field The three were such a constant in the Ivy League across fall weekends that it may have felt the sight of them along the Penn and Columbia (Bagnoli) Harvard (Murphy) and Dartmouth (Teevens) sidelines would last forever The many thousands of people whose lives they touched on their respective campuses and across the nation might say the relationships built are even more vivid they’re legends,” said Ivy League executive director Robin Harris who had a front row seat to three of the league’s winningest and most-impactful coaches competing together for decades only one conference in Division I college football – either in the FCS or the FBS – had more than one active head coach of at least 20 years in its league and it was the Ivy League with Bagnoli (he finished with 30 seasons across 31 years) Murphy (29 across 30) and Teevens (22 across 23) Ivy League football feels so different than just one year ago Bagnoli retired in August due to health reasons The beloved Teevens died at the age of 66 in September while recuperating from injuries sustained in a bicycling accident six months earlier Murphy announced his retirement this past January two months after guiding Harvard to a share of the league title The trio of coaches served as walking encyclopedias of Ivy League history advancing the game and developing student-athletes for even bigger and better accomplishments beyond college Across their combined 84 years in the league While it’s impossible to fill the void left behind the memories of this special time period in the Ivy League are just the opposite – they’re overflowing Eugene Francis “Buddy” Teevens III (Dartmouth Raise your hand if you knew Coach Teevens’ full name.  if you experienced his authentic style.  he also preceded Bagnoli and Murphy into the Ivy League Teevens bled the green and white of Dartmouth from the time he was a student-athlete and played quarterback for the Big Green leading them as a senior to the 1978 Ivy championship and receiving the Asa S Bushnell Cup as the league’s player of the year He also was a member of the school’s successful ice hockey program When Teevens held his first head coaching position at Maine in 1985 and ’86 Murphy served as his offensive coordinator Coaching at his alma mater was a natural for Teevens and he did so while posting a 117-101-2 record (83-70-1 Ivy) over two head coaching stints – first from 1987 to ’91 winning Ivy League titles in his final two seasons with three more championships as well as four second-place finishes including as head coach at Tulane (1992-96) and Stanford (2002-04) But that doesn’t even tell half the story of Buddy Teevens – many feel what he did for football was as important as his success coaching the sport in Hanover Perhaps what made him perfect for the Dartmouth program was the way he related being a Big Green student-athlete to his team Those “old Buddy” stories served as motivation a way of Teevens showing he understood the demands facing his players both on and off the field No project was too big or too small for Teevens whether he trimmed the hedges near Memorial Field or would clear off the Dartmouth logo at midfield after snowstorms He had an acronym or saying for everything “We want a great player when it’s football time and a great man all the time.” “That (saying) meant a lot to him,” Dartmouth athletic director Mike Harrity said “He had so many books always piled up,” his wife Kirsten Teevens said He was always just learning about things.” That included studying about and having concern for player safety and sports-related concussions at a time when football wasn’t showing enough interest in such topics Dartmouth’s tradition-rich program had declined before Teevens’ return and his second coaching stint was off to five straight losing seasons but he still made player safety his priority he suggested the team eliminate tackling between players in practice to lower the risk of injury using only blocking sheds and stationary tackling dummies He maintained the players would become more effective by the decrease in contact “We had to convince people – there were doubters everybody is going to second-guess you,” said Sammy McCorkle “We knew we were going to have to block that out stay true to ourselves and stay true to our beliefs We did a lot of research and we had a plan ready to roll out there And then we knew we were going to have to learn every day about how to adjust Every day we did it and every day we came out with an idea of how we wanted to go about doing this ‘no tackling.’ We got more confident in what we were doing and why we were doing it and that it was going to work “The fact that he came in with this idea at a very it goes to show he was able to keep the outside voices away he was going to follow through on it.”      Always one to connect people around a common cause Teevens partnered the football program with Dartmouth’s engineering department which developed a remote-control tackling dummy called MVP (Mobile Virtual Player) It allowed for practicing tackling technique without player-to-player contact All Ivy League programs eventually followed Dartmouth’s lead in eliminating tackling during practice and ultimately a movement spread across football to encourage safety and make rules changes to try to eliminate brain injuries While appearing before a Congressional hearing on concussions in 2016 Teevens also went against conventional practice by making a big push for female football coaches he named Callie Brownson as the Big Green’s offensive quality control coach which made her Division I football’s first full-time female coach “and did the right things even when it wasn’t popular to do it.” “I looked at Buddy as arguably the Ivy League coach who has had the most impact.”    The Ivy League collectively gasped in March 2023 after Teevens’ accident the football world has rallied with support Dartmouth is hosting a community celebration of his life in May and will rename its home field to Buddy Teevens Stadium at Memorial Field in October whose family shared a close relationship with Teevens has announced the creation of the Buddy Teevens Award which annually will go to a coach who makes a lasting impact in football both on and off the field Ask Al Bagnoli about his funny side and he says because while he was defined by a business-like approach his student-athletes knew he had their best interests in mind and founds way to emphasis their strengths Had Bagnoli not retired for health reasons a month and a half before Columbia’s 2023 season – he underwent a heart procedure earlier in the year – he would have matched former Yale head coach Carm Cozza’s record 32 years in the Ivy League and passed him in games coached (Bagnoli’s 298 were five less than Cozza) Bagnoli had passed Cozza already and ranked second to Murphy in wins (186) and he guided nine Ivy League championship teams at Penn which is the third-most in league history behind the same pair of coaches “What I tried to do through all my tenure is treat everybody with respect and dignity and correctly,” Bagnoli said “And hopefully all the players that I’ve coached felt like I cared about them not only for what they can bring to the field “It’s not necessary a legacy of won-loss records I was blessed to have a lot of really good players.” the 1975 graduate of Central Connecticut State enjoyed stunning success in 10 seasons at Union College – his first season in 1982 produced the Division III program’s first winning record in a dozen years and he went on to go 86-19 and twice reach the national championship game Penn was coming off three straight losing seasons when Bagnoli became head coach prior to the 1992 season and the Quakers went 7-3 in his first campaign then had back-to-back unbeaten teams in ’93 (10-0) and ’94 (9-0) That marked the first time an Ivy program had consecutive 7-0 league records and it occurred two more times under Bagnoli – in 2002 and ’03 then 2009 and ’10 (no other program has done that even once) who featured the Mike Mitchell-to-Robert Milanese passing combo won every league game by 30 points on average and hosted Harvard for ESPN’s first “College GameDay” visit to an FCS host school how to run a program like a CEO of a company I just thought he did a tremendous job with that – working with people who preceded Bagnoli on Penn’s coaching staff and succeeded him as head coach “It was a great learning experience for a number of years.” Bagnoli retired after the 2014 season and accepted a position in Penn’s athletic administration but a funny thing happened shortly afterward – he realized he hadn’t lost the coaching bug.  he was off from Philadelphia to New York to take over Columbia’s struggling program.  The Lions were in the midst of a 21-game losing streak but they became competitive under his guidance An 8-2 record and a tie for second in the league standings in 2017 marked the program’s best season in 21 years four of his final five teams posted winning records and their 35 wins over his seven seasons were the most ever for the program in such a span.  then coached under him at Penn and Columbia and he’s had apprenticeships under both Bagnoli and Murphy.  “I think the kids are very similar,” at both schools The 71-year-old is still involved in fundraising initiatives at Columbia “I think kids want to be coached hard if you coach the right kid They want people who will invest in them and surround them with people who can help them achieve their athletic potential you’ve got kids who are dealing with a lot of outside interest and aren’t just strictly athletes They tend to give back to the neighboring community or whatever their preference is in terms of charity or social work or time but I think Penn has a different expectation having won so many Ivy League championships I think we’re getting to that point now.”  Said Murphy of Bagnoli: “To do what he did at two different schools was just remarkable and you knew it was not going to be an easy day to get a game into the win column.” Add in Union and Bagnoli posted a 269-134 (.667) career record placing him in the top 25 of coaching wins in college football history – no joking matter Which leads back to the funny side of Bagnoli As Priore said about his close friend, “Coach on Saturday at 1 o’clock is a lot different than Coach on Wednesday afternoon at 1 o’clock.”  Bagnoli was already a fixture in the Ivy League when Tim Murphy took over at Harvard prior to the 1994 season Murphy met the challenge in competition while helping to forge a great rivalry of teams and epic games you have to first look back to someone else who pushed Murphy Way back to Buddy Teevens – even before they coached together at Boston U “since seventh-graders at junior high school starting with having played an all-star baseball game against each other and having had a collision at home plate that to this day we would still argue about Murphy’s incredible career at Harvard almost didn’t happen he took graduate courses while he was an assistant at Lafayette and Maine and had decided he would move out of the profession if he wasn’t a head coach by 30 He was accepted into Northwestern’s graduate school of business and was leaning toward enrolling when Teevens left Maine to take over at Dartmouth and Murphy – at 30 – was named the Black Bears’ head coach After his first team earned a share of the Yankee Conference title and qualified for the national playoffs Murphy never stopped being a head coach until his retirement then surprised many by taking a pay cut at the FBS level to become Harvard’s head coach although those people probably didn’t realize that Murphy considered it a dream job to take over in Cambridge It also helped that his first coaching job before Lafayette was on the Brown staff and Murphy found the Ivy League experience to be rewarding The Crimson went 9-1 overall and 7-0 in the Ivies in 1997 as Murphy claimed his first of 10 league championships but it wasn’t until 2001 that they began to string together consecutive winning seasons with the ’01 squad going 9-0 for the program’s first unbeaten and untied season since 1913 and embarking on 16 straight winning records – all 7-3 or better – with eight more Ivy titles The Crimson followed Penn’s first back-to-back unbeaten Ivy teams with a 10-0/7-0 squad in 2004 a team led by Bushnell Cup-winning quarterback Ryan Fitzpatrick, who went on to pass for nearly 35,000 yards in a 17-year NFL career “I told him (Murphy) in-person a thousand times: What he’s accomplished the consistency of that program is probably unparalleled in the history of our league,” Bagnoli said the first thing I think of is his innate ability to develop young men,” said Kyle Juszczyk who was part of Harvard’s solid NFL pipeline under Murphy and now a Pro Bowl fullback in each of the last eight seasons “His demeanor commands respect wherever he is Players work their tails off because they want to earn his approval I have teammates who are intimidated by Coach when we go to alumni events.”  Juszczyk uses a handful of descriptions when he thinks of his former coach – leader I felt like I was always going to be a leader and they were always going to know that I was the head coach,” he said I was one going to be someone that they could look up to someone they knew was going to work his butt off to help them as individuals and as a team to reach all of their goals I hope and believe my players believe I was that person whether it was (to) run off a stage and have them catch me Murphy passed Cozza in 2022 for the most wins by an Ivy League coach Murphy then overtook the legendary Yale coach for the most wins against league opponents the totals were 200 (200-89) and 138 (138-65) the Crimson’s share of the league title was Murphy’s 10th moving him into a tie with Cozza for the league record.  It wasn’t long after the season Murphy’s wife Martha wrote four numbers that ended in zero on a board – 200 her 67-year-old husband didn’t put it all together she pointed out that Murphy had reached 200 wins in Harvard’s 150th season of football across 30 years at the school with 10 Ivy championships ‘I think someone’s trying to tell us something,’” Murphy remembered He and Teevens had always talked about doing that at the same time Technically they didn’t due to Teevens’ passing especially with Harvard sharing the 2023 Ivy title with Dartmouth (under Teevens’ coaching disciple McCorkle) as well as Yale (coached by Murphy’s former assistant Tony Reno) It’s an everlasting image – three icons of Ivy League history each trying to add to the league’s terrific total of football championships – Dartmouth leads with 21 Penn and Yale are close behind with 18 each It all played out with mutual respect on game day then with camaraderie and friendship throughout the year as they aligned over what was best for the league from fullback- and tight end-heavy schemes with a quarterback under center to a wide-open style of shotgun formations and three-wide receiver sets From conference realignment to NCAA transfer portal to NIL the Ivy League didn’t change too much during the Bagnoli Murphy and Teevens era – it was the same eight schools committed to a balance of academic and athletic excellence And the three were drawn to the philosophy “the impact the three of them had on the Ivy League is unbelievable “All three of these men carried the torch for a long time in the Ivy League,” said former Cornell offensive tackle Kevin Boothe who played in the NFL and now directs its management council “and they upheld the proud tradition and raised the bar for the next generation of coaches.”   the Ivy League won’t have either Bagnoli But the three always surrounded themselves with excellent assistant coaches – some of whom have succeeded them – so a new era has dawned.  the Ivy League will embrace what it’s gained from having the three iconic coaches competing together at the same time This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page FILE - Columbia head coach Al Bagnoli runs onto the filed before a game against Princeton during an NCAA college football game on Sept Columbia football coach Al Bagnoli quit Friday night six weeks before the Lions’ opener at Lafayette.(AP Photo/Gregory Payan NEW YORK (AP) — Columbia football coach Al Bagnoli quit Friday night because of health six weeks before the Lions’ opener at Lafayette The 70-year-old was replaced by offensive coordinator Mark Fabish who was promoted to interim head coach for the 2023 season Bagnoli said he had an aortic dissection in February I have decided this is the right time for me to retire from coaching,” Bagnoli said in a statement ” had every intention to get through this season but after going through the recovery process I realized the grind of the Ivy League season would be a lot to go through at this stage of my life.” Columbia is without an Ivy League title since its only one in 1961 Bagnoli won nine Ivy League championships in 23 seasons at Penn then retired after the 2014 season and was hired a few months later by Columbia The Lions went 2-8 and 3-7 in his first two seasons then began 2017 with their first 7-0 start since 1935 and ensured just their sixth winning record since 1951 Columbia finished 8-2 and tied for second place in the Ivy League That started a stretch of four winning seasons in five years around the pandemic-canceled 2020 schedule He will transition into a fundraising and coach mentoring role with the Lions Fabish joined Bagnoli’s Columbia staff in 2015 and has been offensive coordinator for seven seasons Thanks for visiting on the occasion of the conference The Futures of Memory,Atelier Marco Bagnoli in Montelupo Fiorentino unveiled the preview of Atelier Digitale an innovative project by Marco Bagnoli that explores the extraordinary intersections between art and artificial intelligence offering the public a never-before-seen experience.Born in 2023 from an idea by Marco Bagnoli and realized by the Spazio X Tempo Association Atelier Digitale was funded under the PNRR - Next Generation EU with the aim of rethinking the way art is perceived and experienced Come figura d’arciere (1993) and Colui che sta (1992-2004) were scanned in 3D and reproduced in very high definition placed next to the originals in the Atelier’s Alchemical Room allow visitors to interact naturally with the works Interaction with digital works goes beyond pure visual enjoyment: the audience can ask questions about the works themselves the creative process and the artist’s motivations This “dialogue” transforms the works into a bridge between artist and viewer offering an immersive and cognitive experience The project involved a multidisciplinary team led by Professor Alberto Del Bimbo an expert in Artificial Intelligence and Computer Vision from the University of Florence The University of Florence’s MICC (Media Integration and Communication Center) developed the key technology modules: computer vision (to allow the audience to explore the three-dimensional works in a realistic way); speech recognition (to establish a natural dialogue with the works; and ChatGPT-based language model (for detailed and contextualized responses) The model was instructed with information about Marco Bagnoli’s scanned works The process was preceded by a 3-D scan of the works known for her work on the clone of Michelangelo’s David for Expo 2021 in Dubai software has been created to archive and enhance Marco Bagnoli’s entire production providing a valuable tool for scholars and enthusiasts Marco Bagnoli thus wants to redefine the concept of artwork capable of interacting and telling its story This project represents not only a technological evolution but also a new way of emotional and intellectual connection between the public and art An appointment for those who want to discover the new frontiers of the dialogue between human creativity and digital innovation Thanks for visiting The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission ChemosphereCitation Excerpt :Despite the recent advances in foraminiferal biomonitoring the application of standard morphological technique is time-consuming and requires skilled specialists that make it impractical for large-scale biomonitoring surveys (Keeley et al. 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Columbia College | Columbia University in the City of New York COLUMBIA UNIVERSITY ATHLETICS / MIKE McLAUGHLIN At the time I was five years into my tenure as editor-in-chief of CCT before I took this job I was away from Columbia for more than 25 years.” frequent turnover often is a sign of failure When Al Bagnoli took over in February 2015 he inherited a program that had churned through three head coaches in a dozen years (10 since I’d arrived on campus as a first-year in 1967) who announced his retirement from coaching in August for health reasons brought much-needed stability to the Columbia football program it seemed like an impossible dream — those Lions were a non-competitive dispirited football team that was losing games at an alarming rate and losing players as fast as they could be recruited Coming off consecutive 0–10 seasons under Coach Pete Mangurian the team seemed poised to do the unimaginable: make a run at the infamous 44-game losing streak of 1983–88 then the longest in college football history having been moved upstairs following two losing seasons at the end of a stellar 23-year run during which the Quakers had won nine Ivy League championships had grown antsy as an administrator and jumped at the opportunity to return to the sidelines at Columbia with just five winning seasons since the Ivy League began football play in 1956 would be able to inject the necessary energy and enthusiasm into the program or whether he was taking the job for one last big payday before retirement It took two years to scrape off the barnacles but by the time his second full recruiting class arrived on campus in 2017 Bagnoli had planted the seeds for a successful culture change and was about to reap the rewards The 2017 team offered a peek at things to come the Lions drove 54 yards to set up Oren Milstein ’20’s 29-yard field goal as time expired for a 17–14 win Spirit and confidence seemed to grow by the week and by the time the Lions rolled into October’s Homecoming game — coincidentally against Bagnoli’s old team — they’d added three more wins for a 4–0 record Making football fun again: The Lions celebrate after their 34–31 Homecoming win over Penn in October 2017 COLUMBIA UNIVERSITY ATHLETICS / MIKE McLAUGHLIN The difference between that joyous scene and the atmosphere that had surrounded the team in Bagnoli’s first two seasons was striking As co-captain and defensive back Landon Baty ’19 said football has been a blemish on Columbia University Bagnoli led the Lions to a 6–4 record in 2018 and to winning slates in four of the last five seasons (the 2020 campaign was cancelled due to the pandemic) Not since the 1930s Lions teams coached by Lou Little including the squad that won the 1934 Rose Bowl had Columbia compiled a similar string of success Despite a stellar career won-lost record of 269–134 he never led the Lions to the Ivy League championship something even the legendary Little did not achieve But one of the time-honored measures of success is leaving a place in better shape than when you got there Bagnoli did just that as the Columbia’s 20th head football coach Alex Sachare ’71 is a former sports editor of Spectator and a contributing editor to and former editor-in-chief of CCT Published three times a year by Columbia College for alumni Columbia Alumni Center622 W. 113th St., MC 4530, 6th Fl.New York, NY 10025212-851-7852cct@columbia.edu Columbia Alumni Center622 W. 113th St., MC 4530, 4th Fl.New York, NY 10025212-851-7488ccalumni@columbia.edu our student-athletes and our community" is one way Tallmadge Schools Superintendent Steve Wood describes longtime coach and volunteer Larry Bagnoli Now the district has begun the process of renaming the high school stadium in honor of Bagnoli and all he has given to the schools and the community The Tallmadge Board of Education was expected to vote on a resolution at Wednesday's meeting at which point the future board can vote to renew the name Bagnoli knows him to be an ardent supporter of our school our student-athletes and our community,” said Wood “He’s been a part of our football program for over 40 years as a coach and volunteer and has been a positive mentor to all our coaches and players over the years Naming the stadium in his honor is just a small token of our gratitude to him and his family It ensures his influence will remain for decades to come.” "I was shocked," Bagnolli said when he heard about the district naming the stadium after him "I wouldn't have even thought this would happen Football has been a big part of Baginolli's life He played football at Hartville High School and also played football for Heidelberg University Bagnoli began helping the Blue Devils football team as an offensive line coach under Coach Tony Kijanko in 1980 Bagnoli then served as equipment manager for every coach until Joe Vassalotti in 2014 Bagnoli’s favorite role on Friday nights was to provide the game ball to the referees before the game Bagnolli said he enjoyed his decades of working with the Tallmadge Blue Devils football team I'd still be doing that today if my health was good." Some of the tasks he helped with included making spaghetti for the  team's spaghetti dinner making sure the equipment was ready and assisting the coaches Bagnoli was much more than an equipment manager,” said current Tallmadge board president While he’s not on our sidelines much these days he is a strong supporter of our team and is a big help to Coach [Mike] Hay and his staff He’s the perfect example of the type of person who should receive such an honor.” Bagnoli also made an impact while on the Tallmadge Board of Education from 2000-06 His service as a board member along with his strong ongoing advocacy in support of the schools has helped to garner community support for levy campaigns and was instrumental in the transformation of facilities Bagnoli and his family have operated funeral homes in Tallmadge since 1968 Bagnoli has served the Tallmadge community in many ways He is past-president of both the Tallmadge Lions Club and the Chamber of Commerce and is an active member of Tallmadge First Congregational Church Wood said that Bagnoli’s influence on the community is far-reaching and long-lasting Bagnoli is to know a man who has dedicated his life to his community,” added Wood “Tallmadge is lucky to have him as a part of our city And many of us are fortunate enough to have had his world-famous spaghetti sauce.” Get our award-winning print editions of The Daily Pennsylvanian delivered to your doorstep every week The Daily Pennsylvanian is a student-run nonprofit Please support us by disabling your ad blocker on our site Checking in with Penn football alums in the NFL after Week 10 15 Questions with... Ryan Glover, a Penn football senior delivered to your inbox every weekday morning The Daily Pennsylvanian is an independent, student-run newspaper. Please consider making a donation to support the coverage that shapes the University Your generosity ensures a future of strong journalism at Penn Thanks for visiting Metrics details Single-cell RNA sequencing (scRNA-seq) has emerged as a central genome-wide method to characterize cellular identities and processes and cost-efficiency can advance many research questions single-cell RNA barcoding and sequencing (SCRB-seq) is highly sensitive and efficient we systematically evaluate experimental conditions of this protocol and find that adding polyethylene glycol considerably increases sensitivity by enhancing cDNA synthesis using Terra polymerase increases efficiency due to a more even cDNA amplification that requires less sequencing of libraries We combined these and other improvements to develop a scRNA-seq library protocol we call molecular crowding SCRB-seq (mcSCRB-seq) which we show to be one of the most sensitive Each dot represents a replicate (n = 8) and each box represents the median and first and third quartiles per method with the whiskers indicating the most extreme data point which is no more than 1.5 times the length of the box away from the box the interactions between enzymes and buffer conditions are complex and optimizations cannot be easily transferred from one protocol to another it shows that Maxima H- is indeed more sensitive than SmartScribe (5542 detected genes per sample in “Ziegenhain” vs Welch two sample t-test) and that the molecular crowding protocol is the most sensitive one (7898 vs we can show that our optimized SCRB-seq protocol in particular due to the addition of PEG 8000 increases the sensitivity compared to previous protocol variants at reduced costs which may have a lower or higher RNA content than ESCs the cycle number might need to be adapted to generate enough cDNA while avoiding overcycling a less biased amplification and little crosstalk of reads across cells Per-cell distributions are shown using violin plots with vertical lines and numbers indicating the median per protocol this likely makes mcSCRB-seq the most cost-efficient plate-based method available because the data were generated from many varying cell types sequenced in numerous labs mcSCRB-seq sensitivity estimates could be variable across labs and conditions the average ERCC detection efficiency is the most representative measure to compare sensitivities across many protocols c tSNE projection of PBMC cells (n = 349) where each cell is colored according to its expression level of various marker genes for the indicated cell types Expression levels were log-normalized using the Seurat package d Marker gene expression from c was summarized as the mean log-normalized expression level per cell Compared to the previous SCRB-seq protocol mcSCRB-seq increases the power to quantify gene expression twofold optimized reagents and workflows reduce costs by a factor of three we validate our protocol by sequencing PBMCs We show that mcSCRB-seq can identify the different subpopulations and marker gene expression correctly and distinctively detect the major cell types present in the population we found that it was necessary to use different lysis conditions for the PBMCs than for mESCs some cell types may require a more stringent lysis buffer to stabilize mRNA which might be a result of internal RNAses and/or lower RNA content we also provide an alternative lysis strategy for mcSCRB-seq to deal with more difficult cell types or samples mcSCRB-seq is—to the best of our knowledge—not only the most sensitive protocol when benchmarked using ERCCs it is also the most cost-efficient and flexible plate-based protocol currently available and could be a valuable methodological addition to many laboratories in particular as it requires no specialized equipment and reagents universal human reference RNA (UHRR; Agilent) was utilized to exclude biological variability 1 ng of UHRR was used as input per replicate Proteinase K digestion and desiccation were not necessary prior to reverse transcription the total volume for reverse transcription was increased to 10 µl with the exception that we added the same total amount of reverse transcriptase (25 U) thus lowering the concentration from 12.5 to 2.5 U/µl rather preamplification was done per replicate we measured the cDNA concentration using the Quant-iT PicoGreen dsDNA Assay Kit (Thermo Fisher) were compared to determine which enzyme yielded the most cDNA Several dilutions ranging from 1 to 1000 pg of universal human reference RNA (UHRR; Agilent) were used as input for the RT reactions RT reactions contained final concentrations of 1 × M-MuLV reaction buffer (NEB) 1 µM E3V6NEXT barcoded oligo-dT primer (IDT) and 1 µM E5V6NEXT template-switching oligo (IDT) For reverse transcriptases with unknown buffer conditions the provided proprietary buffers were used Reverse transcriptases were added for a final amount of 25 U per reaction All reactions were amplified using 25 PCR cycles to be able to detect low inputs Unblocked (IDT) and blocked (Eurogentec) template-switching oligonucleotides were compared to determine yield when reverse transcribing 10 pg UHRR and primer-dimer formation without UHRR input Reaction conditions for RT and PCR were as described above In order to improve the efficiency of the RT we tested the addition of reaction enhancers The final reaction volume of 10 µl was maintained by adjusting the volume of H2O we added increasing concentrations of MgCl2 (3 and 12 mM; Sigma-Aldrich) in the RT buffer in the presence or absence of 1 M betaine (Sigma-Aldrich) the addition of 1 M betaine and 0.6 M trehalose (Sigma-Aldrich) was compared to the standard RT protocol Both were cultured under feeder-free conditions on gelatine-coated dishes in high-glucose Dulbecco’s modified Eagle’s medium (Thermo Fisher) supplemented with 15% fetal bovine serum (FBS 1000 U/ml recombinant mouse LIF (Merck Millipore) and 2i (1 μM PD032591 and 3 μM CHIR99021 (Sigma-Aldrich)) mESCs were routinely passaged using 0.25% trypsin (Thermo Fisher) mESC cultures were confirmed to be free of mycoplasma contamination by a PCR-based test28 Human-induced pluripotent stem cells were generated using standard techniques from renal epithelial cells obtained from a healthy donor with written informed consent in accordance with the ethical standards of the responsible committee on human experimentation (216–08 Ethikkommission LMU München) and with the current (2013) version of the Declaration of Helsinki hiPSCs were cultured under feeder-free conditions on Geltrex (Thermo Fisher)-coated dishes in StemFit medium (Ajinomoto) supplemented with 100 ng/ml recombinant human basic FGF (Peprotech) and 100 U/ml penicillin Cells were routinely passaged using 0.5 mM EDTA Whenever cells were dissociated into single cells using 0.5 × TrypLE Select (Thermo Fisher) the culture medium was supplemented with 10 µM Rho-associated kinase (ROCK) inhibitor Y27632 (BIOZOL) to prevent apoptosis hiPSC cultures were confirmed to be free of mycoplasma contamination by a PCR-based test28 proteins were digested with Proteinase K (Ambion) followed by desiccation to inactivate Proteinase K and reduce the reaction volume RNA was then reverse transcribed in a 2 µl reaction at 42 °C for 90 min Unincorporated barcode primers were digested using Exonuclease I (Thermo Fisher) cDNA was pooled using the Clean & Concentrator-5 kit (Zymo Research) and PCR amplified with the KAPA HiFi HotStart polymerase (KAPA Biosystems) in 50 µl reaction volumes cells were dissociated using trypsin and resuspended in PBS Single cells (“3 drops” purity mode) were sorted into 96-well DNA LoBind plates (Eppendorf) containing 5 µl lysis buffer using a Sony SH800 sorter (Sony Biotechnology; 100 µm chip) Lysis buffer consisted of a 1:500 dilution of Phusion HF buffer (New England Biolabs) and 0.4 µM barcoded oligo-dT primer (E3V6NEXT plates were immediately spun down and frozen at −80 °C 0.1 µl of 1:80,000 dilution of ERCC spike-in Mix 1 was used proteins were digested by incubation at 50 °C for 10 min Proteinase K was then heat inactivated for 10 min at 80 °C 5 µl reverse transcription master mix consisting of 20 units Maxima H- enzyme (Thermo Fisher) and 15% PEG 8000 (Sigma-Aldrich) was dispensed per well cDNA synthesis and template switching was performed for 90 min at 42 °C Barcoded cDNA was then pooled in 2 ml DNA LoBind tubes (Eppendorf) and cleaned up using SPRI beads Purified cDNA was eluted in 17 µl and residual primers digested with Exonuclease I (Thermo Fisher) for 20 min at 37 °C After heat inactivation for 10 min at 80 °C 30 µl PCR master mix consisting of 1.25 U Terra direct polymerase (Clontech) 1.66 × Terra direct buffer and 0.33 µM SINGV6 primer (IDT) was added PCR was cycled as given: 3 min at 98 °C for initial denaturation followed by 15 cycles of 15 s at 98 °C Final elongation was performed for 10 min at 72 °C all samples were purified using SPRI beads at a ratio of 1:0.8 with a final elution in 10 µl of H2O (Invitrogen) The cDNA was then quantified using the Quant-iT PicoGreen dsDNA Assay Kit (Thermo Fisher) Size distributions were checked on high-sensitivity DNA chips (Agilent Bioanalyzer) Samples passing the quantity and quality controls were used to construct Nextera XT libraries from 0.8 ng of preamplified cDNA 3′ ends were enriched with a custom P5 primer (P5NEXTPT5 Libraries were pooled and size-selected using 2% E-Gel Agarose EX Gels (Life Technologies) and extracted using the MinElute Kit (Qiagen) according to manufacturer’s recommendations Libraries were paired-end sequenced on high output flow cells of an Illumina HiSeq 1500 instrument Sixteen bases were sequenced with the first read to obtain cellular and molecular barcodes and 50 bases were sequenced in the second read into the cDNA fragment When several libraries were multiplexed on sequencing lanes an additional 8 base i7 barcode read was done we mapped to the human reference genome (hg38) while mouse cells were mapped to the mouse genome (mm10) concatenated with the ERCC reference Gene annotations were obtained from Ensembl (GRCh38.84 or GRCm38.75) Downsampling to fixed numbers of raw sequencing reads per cell were performed using the “-d” option in zUMIs we filtered cells by excluding doublets and identifying failed libraries we plotted distributions of total numbers of detected UMIs per cell where doublets were readily identifiable as multiples of the major peak In order to discard broken cells and failed libraries spearman rank correlations of expression values were constructed in an all-to-all matrix We then plotted the distribution of “nearest-neighbor” correlations the highest observed correlation value per cell low-quality libraries had visibly lower correlations than average cells Mouse ES cells (JM8) and human iPS cells were mixed and sorted into a 96-well plate containing lysis buffer as described for mcSCRB-seq using a Sony SH800 sorter (Sony Biotechnology; 100 µm chip) cDNA was synthesized according to the mcSCRB-seq protocol (see above) but without addition of PEG 8000 for half of the plate Wells containing or lacking PEG were pooled and amplified separately Sequencing and primary data analysis was performed as described above with the following changes: cDNA reads were mapped against a combined reference genome (hg38 and mm10) and only reads with unique alignments were considered for expression profiling We selected the most variable genes using the “FindVariableGenes” command (1108 genes) we performed dimensionality reduction with PCA and selected components with significant variance using the “JackStraw” algorithm Statistically significant components were used for shared nearest-neighbor clustering (FindClusters) and tSNE visualization (RunTSNE) Log-normalized expression values were used to plot marker genes For the estimation of cellular mRNA content in mESCs we utilized the known total amount of ERCC spike-in molecules added per cell we calculated a detection efficiency as the fraction of detected ERCC molecules by dividing UMI counts to total spiked ERCC molecule counts dividing the total number of detected cellular UMI counts by the detection efficiency yields the number of estimated total mRNA molecules per cell In order to estimate sensitivity from ERCC spike-in data we modeled the probability of detection in relation to the number of spiked molecules An ERCC transcript was considered detected from 1 UMI we fitted a binomial logistic regression model to the detection of ERCC genes given their input molecule numbers we determined the molecule number necessary for 50% detection probability we obtained count tables from GEO (GSE75790) we calculated molecular detection limits given their published ERCC dilution factors Genes were labeled as significantly differentially expressed between batches with Benjamini–Hochberg adjusted p values <0.01 Analysis code to reproduce major analyses can be found at https://github.com/cziegenhain/Bagnoli_2017 RNA-seq data generated here are available at GEO under accession GSE103568 Further data including cDNA yield of optimization experiments is available on GitHub (https://github.com/cziegenhain/Bagnoli_2017) A detailed step-by-step protocol for mcSCRB-seq has been submitted to the protocols.io repository (mcSCRB-seq protocol 2018) All other data available from the authors upon reasonable request Single-cell sequencing-based technologies will revolutionize whole-organism science Scaling single-cell genomics from phenomenology to mechanism The technology and biology of single-cell RNA sequencing Ziegenhain, C., Vieth, B., Parekh, S., Hellmann, I. & Enard, W. Quantitative single-cell transcriptomics. Brief. Funct. Genomics https://doi.org/10.1093/bfgp/ely009 (2018) Power analysis of single-cell RNA-sequencing experiments Comparative analysis of single-cell RNA sequencing methods Menon, V. Clustering single cells: a review of approaches on high-and low-depth single-cell RNA-seq data. Brief. Funct. Genomics https://doi.org/10.1093/bfgp/ely001 (2018) Soumillon, M., Cacchiarelli, D., Semrau, S., van Oudenaarden, A. & Mikkelsen, T. S. Characterization of directed differentiation by high-throughput single-cell RNA-Seq. Preprint at https://doi.org/10.1101/003236 (2014) A comprehensive assessment of RNA-seq accuracy reproducibility and information content by the Sequencing Quality Control Consortium Smart-seq2 for sensitive full-length transcriptome profiling in single cells Macromolecular crowding allows blunt-end ligation by DNA ligases from rat liver or Escherichia coli CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq zUMIs - a fast and flexible pipeline to process RNA sequencing data with UMIs The impact of amplification on differential expression analyses by RNA-seq Optimal enzymes for amplifying sequencing libraries Quartz-Seq2: a high-throughput single-cell RNA-sequencing method that effectively uses limited sequence reads Dixit, A. Correcting chimeric crosstalk in single cell RNA-seq experiments. Preprint at https://doi.org/10.1101/093237 (2016) The external RNA controls consortium: a progress report Quantitative single-cell RNA-seq with unique molecular identifiers Gene length and detection bias in single cell RNA sequencing protocols powsimR: power analysis for bulk and single cell RNA-seq experiments Massively parallel digital transcriptional profiling of single cells Integrating single-cell transcriptomic data across different conditions Young, M. D. & Behjati, S. SoupX removes ambient RNA contamination from droplet based single cell RNA sequencing data. Preprint at https://doi.org/10.1101/303727 (2018) Targeted mutation of the DNA methyltransferase gene results in embryonic lethality Agouti C57BL/6N embryonic stem cells for mouse genetic resources Bagnoli, J., Ziegenhain, C., Janjic, A., Wange, L. E. & Vieth, B. mcSCRB-seq protocol. protocols.io https://doi.org/10.17504/protocols.io.nrkdd4w (2018) Pooling across cells to normalize single-cell RNA sequencing data with many zero counts ROTS: reproducible RNA-seq biomarker detector—prognostic markers for clear cell renal cell cancer limma powers differential expression analyses for RNA-sequencing and microarray studies voom: Precision weights unlock linear model analysis tools for RNA-seq read counts Download references We thank Ines Bliesener for expert technical assistance We are grateful to Magali Soumillon and Tarjei Mikkelsen for providing the original SCRB-seq protocol and to Stefan Krebs and Helmut Blum for sequencing We would like to thank Elena Winheim for the PBMC sample This work was supported by the Deutsche Forschungsgemeinschaft (DFG) through LMUexcellent and the SFB1243 (Subproject A14/A15) Present address: Department of Cell & Molecular Biology These authors contributed equally: Johannes W Max Planck Institute for Biology of Ageing performed experiments and prepared sequencing libraries The authors declare no competing interests Publisher's note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41467-018-05347-6 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science ChemosphereCitation Excerpt :By applying a simple linear reservoir model to the data (Maillet 1905) we infer a “mean residence time” of 53 days (dotted curves in Fig 4) implying the flow rate at the mouth vanishes only after 165 consecutive dry days A numerical investigation carried out by the authors using the Delft3D software package (Buccino et al. 2021) shows the marine circulation of the Bagnoli bay favors the transport of the water discharged by the Agnano Effluent towards the ILVA's piers which provides indirect evidence of the potential impact of this outfall flow rate data and results of marine current analysis form the input of a particle tracking numerical model (Delft3D- PART) dispersion and settling on the released arsenic we don’t have a legacy admission program—but it might be easier to fund our $50 million-plus annual aid budget if we did You have /5 articles left.Sign up for a free account or log in In the wake of the Supreme Court’s decision to limit the use of race in the college admission process many are interested in solutions that create space for those who have historically been excluded from the country’s highly selective colleges and universities One of the questions that comes up frequently is if colleges and universities boldly assert claims about the value of student diversity and want to prioritize the admission of students who have the most to gain from higher education why wouldn’t they simply eliminate legacy admission programs At a moment like this—when those with legal authority recently determined that affirmative action in admission and the promise of equal protection under the law could not be reconciled—it is tempting to find fault with institutions that exercise “affirmative action for the affluent.” Are these institutions protecting racist and classist systems because of an agenda to preserve inequality I would argue that legacy admission systems—for most of these institutions—reflect a commitment to admitting a diverse class and supporting these students with financial aid I am not a proponent of legacy admissions programs But I understand that it is expensive for selective need-blind institutions to admit students based solely on character and qualifications and simultaneously meet 100 percent of financial need for all who enroll Imagine that legacy advantages were eliminated at the most selective colleges in the country Who would occupy the spaces of those legacy students now that we can no longer consider race among other factors in the admission process I believe it would primarily be upper-class students from families who have had uncommon advantages in life but don’t have ties to that specific selective institution Such a change would hardly be good news for students from historically excluded populations Let’s suppose we eliminate legacy preferences to increase the number of seats available that might go to historically excluded populations With less tuition revenue and philanthropy from wealthy students and families how would annual budgets be funded at America’s most elite institutions our endowment will fund nearly 60 percent of our operating budget this year and we will award need-based financial aid to 65 percent of our students at an average grant of over $52,000 Practicing need-blind admission for domestic students and meeting 100 percent of need for all our students has helped us successfully recruit a diverse highly qualified student body where less than half identify as white U.S Such an investment in financial aid promotes robust student diversity on campus but endowments have limits both in terms of the payout they generate and the restricted use of funds that are part of them They are not a checking account for the institution and must be carefully stewarded to support both operations and need-based financial aid Without the reliability of annual contributions from our endowment our funding model—and that of many need-blind institutions—would not work like those at other selective colleges and universities usually provides adequate returns to meet increasing operational costs without eroding the principal But if operating costs increase more than endowment returns it threatens our long-term ability to deliver a high-quality educational experience cultivating the goodwill of alumni donors through legacy admission programs can help fund significant investment in financial aid It is certainly more financially challenging to support Grinnell students without the philanthropic contribution that legacy admission programs are purported to generate sending a signal that access to selective institutions is a priority we should also ask the department why there isn’t more government support for students with demonstrated financial need who are attending these institutions Student diversity was a by-product of race-conscious admission through which we could examine the full context of an applicant’s identity and experience Many of us preferred that to the anticipated results of a system based more on traditional definitions of merit with race-blind allegiance to the highest test scores and grade point averages Legacy admission programs threaten our illusions of fairness in the admission process by perpetuating a revolving door of opportunity for the wealthiest applicants for admission at the most revered institutions Yet it is also true that many colleges and universities with legacy programs have invested exponentially more time and money in recruiting historically excluded populations than they have the progeny of wealthy alumni they are as racially diverse as they’ve ever been Current predictions and the experiences of selective public institutions in the states that already observe the limited use of race in admission suggest that selective institutions everywhere will likely enroll fewer BIPOC students without the legal protection to consider race as a factor among many in the admission process That will remain true even if we abolish the use of legacy admission at selective institutions the most highly qualified applicants with access to a plethora of advantages will likely replace the überwealthy who currently occupy those spaces I would rather our highest-ranking institutions be afforded the legal protection that served equity goals for generations than place false hope in the premise that abandoning legacy preferences will significantly expand the availability of seats for historically excluded students Joe Bagnoli serves as vice president for enrollment and dean of admission and financial aid at Grinnell College in Iowa He earned a bachelor’s degree from Berea College in Kentucky (which admits only low-income students) and a Ph.D in higher education policy evaluation and analysis from the University of Kentucky Science research funding and programs that help students access college are on the chopping block as Trump aims to cu We need to distinguish between good DEI and bad DEI This alumnus is happy Harvard is fighting for all of higher ed As colleges hire high-powered lobbyists to battle threats to federal funding Subscribe for free to Inside Higher Ed’s newsletters opinion and great new careers in higher education — delivered to your inbox View Newsletters Copyright © 2025 Inside Higher Ed All rights reserved. | Website designed by nclud Today, Italy’s Bagnoli Bay is heavily degraded and largely devoid of marine life. But it wasn’t always this way. By studying environmental DNA trapped in sediments, known as sedaDNA, researchers turned back the clock 200 years to get a step-by-step view of the ecosystem’s decay Beyond showing how far the ecosystem has declined the scientists say this technique could prove a valuable part of restoration efforts in Bagnoli Bay and other degraded areas In 1827, Bagnoli Bay was a picturesque vision of Mediterranean waterfront: it was blanketed in meadows of Neptune grass and home to a diverse array of worms a marine ecologist with Italy’s Anton Dohrn Zoological Station who worked on the environmental DNA analysis The scientists’ research revealed that from around 1851 to the early 20th century the construction of a steelworks and an asbestos plant along with modifications to the bay such as the construction of a causeway between an island and the mainland caused the seagrass and much of the marine life that depended upon it to disappear This included species whose DNA the scientists found buried in the sediment but is not held in any database It’s a classic example of habitat degradation leaving only those species that are able to survive stressful conditions The research effort included local scientists who had seen the more recent phases of Bagnoli Bay’s decline firsthand a marine ecologist at the University of Urbino who lives nearby says the quest to better understand how the bay looked before the Industrial Revolution stemmed from efforts to restore it Though Bagnoli Bay is currently much cleaner than it was at its most polluted A particularly tricky aspect of conservation efforts is knowing what any ecosystem used to look like before modern anthropogenic impacts a marine biologist with the Smithsonian Institution who was not involved in the study sees sedaDNA as a way to address a problem known as shifting baseline syndrome what we see has often been shaped by historical and ongoing human actions we often don’t know exactly what we’re restoring to,” she continues That makes setting realistic restoration targets much more difficult “Having these long-term data sets lets us see what the system was like before human-induced changes,” she says SedaDNA offers more than a before-and-after snapshot Because the sediment is often laid down in layers over time it lets the researchers track how species abundances changed over the decades core sampling revealed the different phases of decline throughout the late 1800s and 1900s It also, adds Eric Capo, an aquatic microbial ecologist at Umeå University in Sweden who also was not involved in the research, offers a way to reconstruct that historical baseline even for times and in places where a proper ecosystem survey had never been performed. “So this is a very powerful tool,” says Capo, who has used the technique to study lake ecosystems a graduate student at Australia’s Deakin University and Project Seagrass who wasn’t involved in the study But it can be part of a toolbox to better understand how ecosystems have changed over time Part of the Tula Foundation and Hakai Institute family Get the best experience and stay connected to your community with our Spectrum News app. Learn More Ohio — Ohio State University has its fair share of die-hard football fans may be surprised to find that two of the biggest OSU fans are actually doctors There are plenty of tailgates around Ohio Stadium but few match the energy and appeal of the Woody Wagon.  Dominic Bagnoli and Travis Ulmer own the OSU-themed ambulance which they’ve decked out in Buckeye memories over the years.  It actually broke down and we had to flatbed it to one of the playoff games to make sure it got there but we’ve got it fixed now and it’s going to be at every game as long as we can make it happen.” Bagnoli has missed just five home games since 1981 he and Ulmer wanted to take their fan experience to a new level.  different ways to set up the tailgate,” Bagnoli said “Travis and I are both emergency physicians Travis had the idea to buy a trailer to put all of our tailgating stuff in Bagnoli said there are countless memories from tailgates “This picture was taken at the national championship game,” Bagnoli said “ESPN road trip came and they had visited us once before Travis and I did the O-H-I-O before the big national championship so that’s a special spot right there for us.” He went to Ohio State for his Bachelor’s degree He said there is nothing like game days on Saturdays in Columbus.  “Buckeye football is just an incredible experience,” Bagnoli said “It’s a great way to spend the weekend with friends and family drive the thing in here and Travis brings it up The outside of the wagon is adorned with OSU’s legendary coaches players and university figures — most of which have signed It even has field turf from inside Ohio Stadium But Bagnoli said his favorite part of the wagon isn’t actually tangible.  “My favorite part of the thing is it’s a meeting place for friends and family to come and enjoy themselves before the game,” he said and my family and Travis’ family and his friends and it’s just a great experience."  and spent north of $20,000 to make it what it is today But there’s no price tag on what it’s worth to them now as it serves as a tribute Ohio State’s greatest coach.  “Woody started this all with his philosophy of pay it forward” Bagnoli said it’s part of us celebrating those relationships." An official website of the United States government N.Y.—Transportation Security Administration employees at Albany International Airport have a long memory They remember what it was like a year ago during the government shutdown when they worked for weeks without getting paid But more important is that they remember the generosity of members of the community who came through the airport and dropped off food gift cards and sometimes even cash to help the TSA officers get through that rough period And they remember the meals that the airport community provided to support the TSA team until the furlough ended and their paychecks arrived So when a drive-through food bank was scheduled to take place in one of the airport parking lots to help people who have been laid off work or seen their work hours and paychecks reduced as a result of the pandemic several TSA employees volunteered to assist “It’s all about paying it forward,” said Supervisory TSA Officer Frank Genovesi who was one of several dozens of volunteers who helped distribute food when the Food Bank of Northeastern New York recently arranged for bags and boxes of fresh produce meat and boxed and canned goods to be distributed to residents of the Capital Region from one of the airport parking lots The pandemic has resulted in “a difficult time for everybody and I wanted to help out because during the government shutdown the community came together to help TSA and it was important for me to do the same for them I felt honored to be able to take part” in the distribution of the food “The Albany International Airport is fortunate to have such a dedicated workforce to participate in events such as these,” said TSA’s Upstate New York Federal Security Director Bart R “It’s great to see TSA employees helping others in giving back to the community.” TSA Manager Shawntae Jones also volunteered to assist the food bank in its distribution The people who drove through the food bank’s distribution line “were overwhelmed with what was being distributed,” Jones said “There was really a nice amount of food—chicken vegetables.” Jones said that she volunteered “because during last year’s furlough people in the community took care of us when we were not being paid The food distribution was set up like a factory’s assembly line with volunteers each staffing a station TSA Manager Mary Bagnoli was stationed at the end of the assembly line as cars drove through She distributed Egg Beaters and also asked drivers if they had kids so that she could also hand them coloring books decals and little wooden wind-up airplanes for kids that were provided by the airport “The community came through for TSA during the furlough and I figured this was the least I could do to give back,” she said By Rebecca Wachen Graphics by Andrew Park one tradition has remained constant during the Columbia football season: Homecoming An institution that has remained intact for over 80 years Columbia football’s annual Homecoming game is considered the most popular sporting event hosted at Baker Athletics Complex bringing thousands of fans together into Wien Stadium While students may typically elect not to make the 30-minute commute to the athletic complex for a regular season game many more students choose to make the trip uptown for Homecoming one of the co-champions for the 2021 Ivy League season will be ready to seek redemption for last season’s game when the Lions stunned the Big Green 19-0 in Hanover for its only Ivy loss of the season Columbia football has not had much historical success in the annual contest and apart from one five-year winning streak from 1994-98 the Light Blue has never won more than two Homecoming games in a row head coach Al Bagnoli has created a different narrative for Columbia football During his time as the head football coach of the Penn Bagnoli led the Quakers to an overall homecoming record of 16-7 the Lions had a 21-52-1 record at Homecoming games But since Bagnoli joined the Light Blue prior to the start of the 2015 season Columbia played its first-ever Homecoming game against Cornell The Lions have played a Homecoming game every year since except in 2020 when the season was cancelled due to COVID-19 Columbia has won four and lost two Homecoming matches Bagnoli brought Columbia football its biggest Homecoming win ever tied for the second worst Homecoming loss in program history Columbia has only won five Homecoming games Before Bagnoli won his first Homecoming game in 2016 the last time Columbia won a Homecoming game was in 2000 In Bagnoli’s first Columbia Homecoming game The loss extended the Lions’ Homecoming losing streak to 15 games which remains the longest Homecoming drought in program history But Bagnoli and the Lions would not let the drought worsen He earned his first Columbia Homecoming win in 2016 with a low-scoring 9-7 win over the Big Green Bagnoli’s winning ways continued into the next Homecoming when the Lions persevered in what Columbia Athletics calls the greatest Homecoming win in its history After trailing 21-7 to Penn in the fourth quarter scoring 21 unanswered points in the quarter to force an overtime period the Quakers scored first with a field goal to regain their lead threw a 24-yard game-winning touchdown pass to Josh Wainwright Bagnoli’s dramatic walk-off win against Penn not only earned him his second straight Homecoming victory but it also broke Columbia’s 19-game losing streak against Penn the majority of Penn’s wins were overseen by Bagnoli himself Bagnoli’s winning trend did not continue the following year Bagnoli and the Light Blue turned things around the next Homecoming the largest Homecoming victory in Columbia history because we haven’t won at home yet this year and that was our big thing this week was protecting our house,” former Columbia cornerback Ben McKeighan in a Homecoming game—it’s really important.” While the annual tradition had to come to a halt in 2020 due to the COVID pandemic winning 23-14 against Penn in the 2021 Homecoming game With the crowd involved throughout the whole game the Lions were able to build off their fans’ momentum “It’s always nice to be supported—I think I’ll speak for everybody,” Bagnoli said after last year’s game With the Big Green returning to New York City for its first Homecoming game since 2018 the Lions will again be looking to maintain a winning narrative Bagnoli will be gunning to move his Homecoming winning streak up to three the win would create the second longest winning streak in Homecoming history The Homecoming game will take place on Oct Fans who are unable to attend the game in person can stream it ESPN+ or SNY Deputy Sports Editor Rebecca Wachen can be reached at rebecca.wachen@columbiaspectator.com. Follow her on Twitter @rebecca_wachen Graphics Editor Andrew Park can be reached at andrew.park@columbiaspectator.com. Follow him on Twitter @androo_park Want to keep up with breaking news? Subscribe to our email newsletter and like Spectator on Facebook Produced with Spectate by the Spectator Graphics team Al Bagnoli Columbia's Patricia and Shepard Alexander Head Coach of Football has assembled an outstanding collection of coaches to join him on Morningside Heights “I am very pleased to officially announce the 2015 coaching staff I have spent the majority of my short tenure trying to find the correct fit and balance relative to age energy and football wisdom,” Coach Bagnoli said. “Given all of the great resources Columbia has I had the good fortune of being able to attract a quality group of individuals who are not only excellent coaches I feel quite confident they will do an excellent job representing our football program athletic department and Columbia University.” Michael Faragalli will serve as Columbia's Offensive Coordinator/Assistant Head Coach of Offense and QB Coach Faragalli's resume includes extensive experience as both an assistant as well as a head coach he has served as an assistant coach at Rhode Island (1981) Virginia State (2013) and Christopher Newport (2014).  I have tried to hire Mike on several previous occasions during my tenure at Penn I have known him since our days competing against each other while he was at Lafayette and was always impressed with his offensive production and creativity as well as his play calling skills Jonathan McLaughlin will serve as the Offensive Line Coach and Run Game Coordinator.  McLaughlin was at Penn with Coach Bagnoli for the past nine years as the offensive line coach and was also the offensive coordinator for the Quakers for the past six years Jon was my offensive coordinator and offensive line coach while I was at Penn He was an integral part of our offensive staff which produced three outright Ivy League championships. Jon is an excellent teacher coach and recruiter and was the first person I reached out to hire He will bring a toughness and tenacity to the offensive line Mark Fabish has been named Associate Head Coach and Wide Receivers Coach Fabish served as the passing game coordinator and wide receivers coach at Penn for the last six years Fabish won two Ivy League Championships as a student-athlete and coached three championship teams on the sidelines at Penn Mark was the other coach I “recruited” from Penn. Mark served as our wide receivers coach and recruiting coordinator as well as a member of my offensive staff which produced three outright championships He is a former great player at Penn and part of my first recruiting class Mark will be a great fit as he is a North Jersey native who played at Bergen Catholic Joseph D'Orazio will coach the tight ends a 2011 Penn graduate and two-time first team All-Ivy League offensive lineman has worked as the senior assistant to the head coach of the Kansas City Chiefs Joe is a former outstanding player at Penn who garnered multiple All-Ivy League honors at offensive center and was part of multiple championship teams. Joe was coached by Jon McLaughlin during his tenure at Penn which should help us as we transition into a different offensive blocking scheme accomplished individual with an excellent future in coaching Todd Gilcrist will coach the running backs.  Gilcrist comes to Columbia from Carnegie Mellon University where he was the wide receivers coach Gilcrist played football at the University of Pittsburgh for three years and graduated from Pitt in 2012 Todd was an outstanding player at the University of Pittsburgh whom we first met when he worked our summer camps at Penn Todd possesses outstanding people skills and is an excellent communicator and teacher He will provide the program with great passion and energy He will also do a great job relating to our current players Paul Ferraro, a coach with more than 30 years of experience at the highest levels of football Paul brings a wealth of experience as both a defensive coordinator and kicking game coordinator He has coached at all levels of college as well as in the NFL He possesses great technical expertise along with a long history of calling defenses Paul has coached every position on defense and will bring a toughness and tenacity to that group Darin Edwards will coach the defensive line.  Edwards comes to Columbia from Fordham where he coached the defensive line last season Edwards coached six years at Sacred Heart.  He was the defensive line coach at Fordham University last season and played an integral part in the development of an outstanding defensive front The staff and I were very impressed with his passion Justin Stovall will be the Linebackers Coach and Special Teams Coordinator Justin is another one of our young coaches who possess great energy and will bring excitement and enthusiasm to our players and program he has extensive experience as both a positional coach I have known him since his playing days at Lafayette College where he was an accomplished all-league linebacker Jon Poppe has been named Secondary Coach and Recruiting Coordinator Poppe comes to Columbia from Harvard where he worked with the secondary since 2011 Poppe also worked at Holy Cross and Springfield College Bagnoli on Jon Poppe: Jon was one of the first coaches I targeted when I arrived He has spent the previous five years working with the secondary at Harvard as well as serving as one of their west coast recruiters as both his father and brother are Columbia graduates he is another North Jersey guy who went to Bergen Catholic and has great contacts throughout the state Jon possesses an outstanding combination of technical expertise a thorough knowledge of the league and a high energy level Full biographies of the new football coaching staff will be updated on gocolumbialions.com throughout the week Thanks for visiting Thanks for visiting The Ohio State University Board of Trustees today approved moving forward on the largest single facilities project ever undertaken at the institution – a new 1.9 million-square-foot inpatient hospital that will enhance leading-edge research clinical training and world-class patient care The board approved professional services and construction contracts to build the Wexner Medical Center Inpatient Hospital. Scheduled to open in early 2026, the hospital has a total project cost of $1.79 billion (see related story) The project will be funded with auxiliary (health system) funds the board approved a $700,000 increase in professional services and construction contracts for the Morehouse chiller and electrical distribution project which will enhance infrastructure and address aging building systems in support of clinic operations Total project budget is $4.7 million to be paid with health system funds executive director of the Ohio Beef Council and the Ohio Cattlemen's Association former director of the Ohio Department of Rehabilitation and Correction Mike DeWine to serve nine-year terms ending in May 2029 They replace Columbus attorney Alex Shumate and Timothy P The university’s 2020-2022 Strategic Completion Plan will be forwarded to the chancellor of the Ohio Department of Higher Education The next phase of the State of Ohio Adversity and Resilience (SOAR Study) is now accepting participants across western Ohio at Mercy Health – St Students in Ohio State’s Hospitality Management Program put their leadership skills to work by planning the Big Dish event this spring.  A little rain didn’t stop the 2025 spring commencement at The Ohio State University As students and loved ones alike pulled out umbrellas and ponchos Marine Corps (Ret.) and NASA administrator from 2009-2017 Please enable JS and disable any ad blocker « Back secretariat@globalinitiative.net Avenue de France 23 – Geneva, CH-1202 – Switzerland IRPI – Investigative reporting project Italy Lorenzo Bagnoli is board member of the Investigative Reporting Project Italy (IRPI) a centre for investigative journalism based in Italy He holds a Master in Journalism awarded by the Catholic University in Milan Currently he is also a contributor at Il Fatto quotidiano He has been awarded three times with a grant by Journalism Fund: twice with the “Mafia in Africa” project and once with a cross-border investigation about the European Security complex Ecologist and Enviornmental Sciences (Social Environmental analysis) Investigative journalist and security specialist Graduate Institute of International and Development Studies The Strategic Hub for Organised Crime (SHOC) Research Network of the Royal United Services Institute secretariat@globalinitiative.net Avenue de France 23 – Geneva, CH-1202 – Switzerland Design e Creative Coding by Café Metrics details The use of antibiotics has enabled the successful treatment of bacterial infections saving the lives and improving the health of many patients worldwide the emergence and spread of antimicrobial resistance (AMR) has been highlighted as a global threat by different health organizations and pathogens resistant to antimicrobials cause substantial morbidity and death novel and effective therapies as well as prevention strategies are needed we discuss evidence that vaccines can have a major role in fighting AMR decreasing the number of infectious disease cases and thus antibiotic use and the emergence and spread of AMR We also describe the current state of development of vaccines against resistant bacterial pathogens that cause a substantial disease burden both in high-income countries and in low- and medium-income countries discuss possible obstacles that hinder progress in vaccine development and speculate on the impact of next-generation vaccines against bacterial infectious diseases on AMR Prices may be subject to local taxes which are calculated during checkout Action and resistance mechanisms of antibiotics: a guide for clinicians Correlation between antimicrobial consumption and antimicrobial resistance of Pseudomonas aeruginosa in a hospital setting: a 10-year study Measuring and mapping the global burden of antimicrobial resistance IACG No Time To Wait: Securing The Future From Drug-Resistant Infections (2019) Political Declaration of the High-Level Meeting of the General Assembly on Antimicrobial Resistance Antibiotic resistance: a rundown of a global crisis Why the evolution of vaccine resistance is less of a concern than the evolution of drug resistance This review compares emergence of drug resistance and vaccine resistance and explains why vaccine resistance is not a major concern Technologies to address antimicrobial resistance This review describes how innovative vaccine technologies have the potential to boost the development of vaccines targeting several classes of multidrug-resistant bacteria Impact of existing vaccines in reducing antibiotic resistance: Primary and secondary effects The role of vaccines in preventing bacterial antimicrobial resistance This review highlights the value of vaccines as one of the modalities to combat AMR globally Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis CDC. 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"We are excited to have Letizia and Vanessa join our team next fall," said Dailey. "They are both very accomplished players and students and will be a great addition to our team. Both have extensive competitive experience and know how to win. They are members of their respective national teams and have played at the highest level. They are wonderful, engaging young ladies and we are thrilled to have them join our Wake Forest family." Knecht is from Zurich, Switzerland, where she has been a member of the Swiss Ladies National Team. Ranked No. 253 in the World Amateur Golf Rankings, she won the 2016 Liechtenstein Open and the 2016 Swiss National Match Play Championship. She has also had a runner-up finish at the Total International Juniors of Belgium and a top-five finish at the Spanish International Stroke Play Championship. Bagnoli and Knecht will join a Demon Deacon program that concluded the fall schedule ranked No. 23 nationally by GolfStat. Text description provided by the architects. The project is located on the site of an abandoned steel factory, which had been created following World War II to help with the reconstruction of the Mezzogiorno region of Southern Italy. Following the plant’s closing, it was decided that the site should retain the concept of “reconstruction,” but this time on a local level. Thus, the idea for a cultural center for local residents and tourists came about. which can be seen more as an extension of the public plaza Its sloped facades contain 960 integrated photovoltaic cells (spread over 1,420 m²) will be capable of producing up to 265,000 kW per year This complex is accessible via a smaller domed structure (a sort of “cupola” – a subtle hint at the nearby Roman ruins of the Temple of Diane) Visitors the fitness center and wellness center will have access to additional amenities such as a restaurant in addition to the requisite programmatic elements (spas You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email