Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application It is with profound sadness that the family of Christina “Chris” Caserta announce her untimely passing on March 3 She proudly graduated Ridley high school in 1979 She remained committed to her classmates and stayed in contact over the years with many from her neighborhood and school. Chris believed in the servitude of others as a value that guided her life She was a successful hairdresser of almost 50 years and gave priority to those vulnerable in nursing and assisted living facilities Chris’ energetic and vivacious personality brought light to everyone around her and her clients faithfully adored her Chris was an outstanding mother to Desiree They were constantly in contact if they weren’t together Chris loved to visit the Jersey shore with her daughter’s family. Chris was an exceptional grandmother (Nonna) Both were delighted to take trips to various playgrounds Chris had many social circles and enjoyed attending various church Bible studies and church groups Her intentional relationships made with everyone she met included a commitment to meaningful conversations and following up to support someone She lived to serve other people and to demonstrate a Christ-like forgiveness that would disarm even the hardest of hearts Chris attended Planet Fitness every day and prioritized daily physical fitness Chris was a genuine supporter of all things police and military and was looking forward to making America healthy and great again. Relatives and friends are invited to honor Chris’ life at her Viewing 9:30 to 11:30 AM at The Donohue Funeral Home followed by her Funeral Service beginning at 11:30 AM contributions in Chris’ memory would be appreciated to the Upper Darby Township Police Department Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors The latest news and information from the world's most respected news source BBC World Service delivers up-to-the-minute news Police arrested the veteran New Castle County officer in August Now a lawsuit claims the victim's sexual orientation precipitated the attack New Castle County would not provide a photo of Justin M a 20-year veteran of the force who was put on leave after the incident last summer but he continues collecting his $105,200 annual salary Lawsuit against Justin Caserta by Cris Barrish but he also shared child porn and convinced a 16-year-old Ohio girl to send explicit pics who worked as a paraprofessional in the Caesar Rodney School District when he was allegedly attacked said he remains mystified by what transpired during the party at an old friend’s house in the midstate town of Smyrna Molina said he has known the retired county cop who owns the home The so-called “Beer Olympics” involved a series of games that involved imbibing He’d been drinking earlier in the evening but was “in my right mind” when the incident occurred about midnight The violence happened as he was talking with the owner’s daughter and Caserta’s son At one point Caserta’s son was “sort of fixing himself up in the mirror” and the girl teased him Don’t worry about it.’ It’s my impression that Justin heard these comments and afterwards came up to me and said ‘What the f— is going on right now?’” Molina said He grabbed me by my lapel and dragged me outside threw me down and got on top of me and choked me to the point of being unconscious and foaming at the mouth a nurse who has known Molina since middle school and accompanied him to the party of their mutual friend saw the commotion and rushed over to the chaotic scene She found Molina “dazed and confused,” then ran to Justin Caserta and confronted him What’s going on?’” she recalled demanding to know Giddings said the accusation was ridiculous The free WHYY News Daily newsletter delivers the most important local stories to your inbox WHYY is your source for fact-based, in-depth journalism and information. As a nonprofit organization, we rely on financial support from readers like you. Please give today. Cathell didn’t tell lower-ranking officers that hundreds of overtime shifts were available A 45-page report released last week found repeated incidents of police misconduct by Trenton police officers Together we can reach 100% of WHYY’s fiscal year goal local news and information and world-class entertainment to everyone in our community WHYY offers a voice to those not heard, a platform to share everyone’s stories, a foundation to empower early and lifelong learners and a trusted space for unbiased news. Learn more about Social Responsibility at WHYY Please enable JS and disable any ad blocker Peggy Caserta was a force to be reckoned with loved her very much and instilled in her the meaning of loyalty and compassion which she gave to them in return and to the people she cared about throughout her colorful life Her high school experience was rich with achievements and being the little kids’ favorite swimming instructor at the country club Peggy trained as a “stewardess” and started flying out of New York with Delta Airlines She initially liked it until she discovered that she had severe motion sickness and didn’t like serving coffee She sensed a subtle shift amongst her peers that called her Peggy opened a clothing store that became a magnet attracting thousands of wide-eyed innocents to the corner of Haight and Ashbury hung out at the store and dreamed of making it big She bought Jerry Garcia his first amplifier sold Janis one of the first pairs of bell-bottom jeans Her store was a safe place for young “hippies” to congregate which partly sparked the counterculture revolution She convinced Levi Strauss & Company to create the first bell bottoms flares exclusively for her store Her ability to manage and navigate the ups and downs in the decades that followed is a testament to her courage and tenacity is a wonderfully well-written account of her life and times She fulfilled her dream of living out the final days of her life in her cabin on the Tillamook River and The Old Oregon Smokehouse and The Crazy Torta were two of her favorites because the food was very good but she was also treated with great kindness and respect…which meant everything to her Thank you for all that you contributed to the making of a movement We and our partners use technology such as cookies on our site to personalize content and ads Click below to consent to the use of this technology across the web You can change your mind and change your consent choices at anytime by returning to this site https://www.tillamookcountypioneer.net/eula-privacy-policy/ Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here By continuing to use our site, you agree to our Private Policy and Terms of Use perform at the Festival for Peace at Shea Stadium Caserta and Joplin had an intense relationship from 1966 to 1970 Peggy Caserta, a lover of rock icon Janis Joplin, has died at age 84 Caserta died last Thursday at her home, a cabin on the Tillamook River in Oregon, Deadlinereports She was born in 1940 in Louisiana. She worked as a New York City-based flight attendant — unhappily — for a period before moving to San Francisco in the mid-1960s She opened a clothing boutique there in the Haight-Ashbury neighborhood “Already living openly as a lesbian when that was a rarity even within the ostensibly liberal though thoroughly heteronormative hippie culture Caserta boldly called her new Haight-Ashbury shop Mnasidika after a character in the iconic Sappho-inspired poetry collection The Songs of Bilitis,” Deadline notes She dressed the Grateful Dead and other musicians, and created what came to be known as bell-bottom jeans which she eventually got Levi Strauss to make for her store Caserta came up with the idea for the jeans after seeing a woman wearing a version “One of the early hippie-ish type girls had split the side seam on her boyfriend’s jeans and inserted a paisley triangle,” she explained to Levi Strauss according to a 2019 article on the company's website Caserta then paid the woman to make some with denim Caserta went to Levi Strauss and struck a deal with the company and that night Caserta went to see Joplin sing with her band The performance was “powerful and mind altering,” Caserta wrote in her second memoir Joplin went into Caserta’s boutique to buy some jeans on layaway one that would include voracious sexual appetites and an equally enthusiastic devotion to heroin,” Deadline reports neither Caserta nor Joplin described their relationship as girlfriends or lovers Caserta has said she believes Joplin was straight but “wild,” although Joplin had several female romantic partners “I adored her. I loved her,” Caserta told New York Magazine’s Vulture blog in 2018 “But to be her lover was to resign yourself to being invisible and as hard as it may be for people to understand now Caserta was with Joplin when the singer performed at Woodstock in 1969 and the two were supposed to be together on the final night of Joplin’s life a man with whom Joplin had just begun a relationship But “either through miscommunication or druggy inertia,” as Deadline puts it neither Caserta nor Morgan arrived at Joplin’s hotel room in Los Angeles; the singer had been recording her final album Joplin died early the next day after shooting heroin Caserta asserted in I Ran Into Some Trouble that Joplin’s death was due not to a drug overdose but to a fall and a broken nose that caused her to suffocate from blood Caserta regretted missing the rendezvous with Joplin I regret that I wasn’t there that night when she tripped and fell Caserta continued to be addicted to heroin, and she published her first memoir, Going Down With Janis, in 1973. She has disavowed much of the book, blaming her ghostwriter, Dan Knapp. She said she received $2,000 for it, which all went to her heroin habit. But many LGBTQ+ people welcomed the book for revealing Joplin’s queerness that lurid and graphic sexual content and the drug scenes depicted was published by Wyatt-MacKenzie Publishing in Oregon in 2018 Caserta eventually overcame her drug habit and spent several years caring for her mother, who was suffering from dementia, beginning in 2005. After that stint in Louisiana, Caserta settled into her cabin on the Oregon coast, and “she loved the community” there, the Tillamook County Pioneernotes This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Caserta wrote two memoirs about her time with the rocker including 1973's 'Going Down with Janis' and 2018's 'I Ran into Some Trouble' Craving pizza Longtime favorites are popular as ever even as newcomers are staking their claim You can have it all from Providence to Westerly The National Day calendar has declared Feb. 9 as National Pizza Day They also shared some interesting facts such as that pepperoni is the most popular pizza at 36% of all orders where 17% of all restaurants are pizzerias Perhaps that's why Americans consume on average 23 pounds of pizza per person each year If you want to sample the best pizza in Rhode Island Providence chef Robert Andreozzi of Pizza Marvin opened their old-style pizza parlor with a modern menu of food and cocktails in a small space on Wickenden Street just five years ago That doesn't happen to chefs at many pizzerias It's one of the most prestigious honors in the culinary world You can taste why with the clever Chowdah Pie with clams But it's hard to beat the classic House Cheese with the perfect sauce made with organic New England flour milled from local grains You'll also find the flavor for the thick pizza slices that are oh-so satisfying Details: 468 Wickenden St., Providence, (401) 262-3336, pizzamarvin.com When chefs wanted to raise the quality of pizza they applied what they learned from bakers about fermentation It seems like he was talking about James Wayman. He is the executive chef and a partner at Nana’s. He's also a founding partner and creative director of Moromi Shoyu He explained they use its koji to amplify the umami in their pizzas You'll recall it's the fifth basic taste – savory – after sweet One bite of the classic Margherita and it's unlikely you'll forget it anytime soon This is not your nana's pizza but a pie with an ethereal crust and a perfect balance of cheese and sauce Details: 82 High St., Westerly, (401) 213-3911, nanasri.com Mother Pizzeria comes from chef Kevin O’Donnell (Giusto) It's named after the starter or "Mother" used in sourdough baking The pizza is made from naturally fermented dough using local stone ground flour It's baked in a Marra Forni Neapolitan-style pizza oven Mother Pizzeria was named a 50 Top Pizza USA 2024 as an "Excellent Pizzeria." They said the pizza was fresh with seasonal ingredients and they liked the intention to cook healthy food The sourdough pizza is light and airy as a feather and features a bright sauce Pair it with a lovely appertivo for the perfect dinner The Roman-style 12-inch square pies are available to go Build your own or choose one of our specialty pies Bonus: Soon a second Mother will open in Track 15 the Providence food hall in the former Union Station Details: 49 Long Wharf Mall, Newport, (401) 324-5500, motherpizzeria.com But it is a taste of home for me and many others I hope I'm not alone in having to put it in the trunk so I don't eat it on the ride home The aroma of the cheese and sauce and pepperoni pairs wonderfully with the thick crust for many satisfying bites 21 Spruce St. (401) 621-3618, casertapizzeria.com Pasquale’s Pizzeria Napoletana in Wakefield has been owning a high spot on a pretty exclusive international best pizza list. The international organization 50 Top Pizza put Pasquale's at No. 14 last year and No Owner and pizzaiolo (pizza maker) Pasquale Illiano was No Now that wouldn't mean anything if the pizza wasn't wonderful The pizza will disappear from your table but remain on your mind for days My favorite is a wood-fired Margherita that is topped with San Marzano tomatoes But the best is the fior di latte mozzarella that's so creamy Details: 59 South County Commons Way, Wakefield, (401) 783-2900, pasqualespizzeriari.com Blackie's has not one but two Italian pizza ovens so one can be dedicated to making gluten-free pizza. Details: 280 George Washington Highway, Smithfield, (401) 231-4777, eatatblackies.com Al Forno helped start a well-documented culinary revolution for upscale sophisticated dining in Providence with simple One of the signature dishes is their grilled pizza maybe a topping of prosciutto or sweet corn Details: 577 South Water St, Providence, (401) 273-9760, alforno.com Chef Brian Kingsford learned his craft at Al Forno before opening Bacaro, his own restaurant with business partner Jennifer Matta. Their menu is all about sharing the best flavors of Italy. But their modern pizza, grilled to perfection, can't be beat. They also offer a choice of topping combinations that change seasonally. Details: 262 South Water St., Providence, (401) 751-3700, bacarorestaurant.net Bar'Cino's grilled pizza is a superb version with a thin, crispy crust, dabbles of cheese and sauce and finished with fresh basil. That's their Margherita Pomodoro but you can try with spicy sausage, ham and fig or even chicken. Details: 22 Washington Square, Newport, (401) 619-8201, barcino.com Max Mara has announced that its Resort 2026 collection will be showcased at the Reggia di Caserta on June 17 a former royal palace approximately 23 miles from Naples is recognized as a UNESCO World Heritage Site This 18th-century Baroque and Neoclassical structure was initially constructed as the main residence for the House of Bourbon-Two Sicilies when they were kings of Naples features 1,200 rooms and includes a theater inspired by the San Carlo in Naples covering 120 hectares and incorporating hilly terrain draws inspiration from the Palace of Versailles The Max Mara show is scheduled to coincide with the first day of the international menswear trade show Pitti Uomo which begins in Florence on June 17 and continues until June 20 This will be followed by the men’s shows for Spring 2026 in Milan Max Mara staged its Resort 2025 show in Venice at the Palazzo Ducale and the year before at Stockholm’s City Hall a notable city symbol known for its tower and red brick facade which also hosts the Nobel Prizes for literature and the sciences This marks the second time Max Mara has chosen Southern Italy for its resort collection; in 2021 the brand hosted its show on the island of Ischia at the Mezzatorre Hotel set in a 16th-century watchtower overlooking the Gulf of Naples Max Mara has also held resort shows in various global cities including New York Other upcoming destination shows include Moncler Grenoble’s fall 2025 show in Courchevel on March 15; Pucci in Portofino on April 4; Dior Pre-Fall in the garden of Tō-ji Temple in Kyoto on April 15; Chanel Cruise on Lake Como on April 29; Gucci Cruise in Florence on May 15; Louis Vuitton Cruise in France on May 22 with details yet to be announced; and Dior Cruise in Rome on May 27 Metrics details Here we report spillover of the HPAI H5N1 virus to dairy cattle across several states in the USA The affected cows displayed clinical signs encompassing decreased feed intake respiratory distress and decreased milk production with abnormal milk Infectious virus and viral RNA were consistently detected in milk from affected cows Viral distribution in tissues via immunohistochemistry and in situ hybridization revealed a distinct tropism of the virus for the epithelial cells lining the alveoli of the mammary gland in cows Whole viral genome sequences recovered from dairy cows domestic cats and a raccoon from affected farms indicated multidirectional interspecies transmissions Epidemiological and genomic data revealed efficient cow-to-cow transmission after apparently healthy cows from an affected farm were transported to a premise in a different state These results demonstrate the transmission of the HPAI H5N1 clade 2.3.4.4b virus at a non-traditional interface underscoring the ability of the virus to cross species barriers The continuous and widespread circulation of this high-consequence panzootic pathogen is of major concern and poses a substantial threat to animal and public health Here we report the spillover of the HPAI H5N1 virus clade 2.3.4.4b into dairy cattle and describe the findings of a clinical pathological and epidemiological investigation in nine affected farms (farms 1–9) across four states in the USA The clinical disease in dairy cattle lasted 5–14 days with animals returning to pre-outbreak health status but maintaining decreased milk production for at least 4 weeks A similar epidemiological scenario involving mortality events in domestic and wild mammals was observed in farms 3–5 and 8 Six domestic cats died in farm 3 after the disease onset in dairy cows Cats found dead on farms 4 and 5 and cats and a raccoon found dead on farm 8 tested positive for HPAI-H5 faecal (n = 10) and milk (n = 167) samples collected from cattle from farms 1 to 9 quantified by rRT–PCR targeting the IAV matrix gene Viral RNA loads in tissues of dairy cattle quantified by rRT–PCR targeting the IAV matrix gene Serum antibody responses in affected cattle (n = 19) quantified by a haemagglutination inhibition (HI) assay Cytopathic effect of the HPAI H5N1 virus isolated from milk in bovine uterine epithelial cells Cal-1 The photomicrographs shown are representative of two independent clinical samples Detection of the infectious HPAI virus in Cal-1 cells by an immunofluorescence assay using a nucleoprotein-specific monoclonal antibody (red) counterstained with 4′,6-diamidino-2-phenylindole (DAPI Infectious HPAI H5N1 virus in milk (n = 69; f) and tissues (g) detected by virus titration Virus titres were determined using end point dilutions and expressed as 50% tissue culture infectious dose (TCID50) per millilitre (TCID50 ml−1) The limit of detection for infectious virus titration was 101.05 TCID50 ml−1 Data are presented as mean ± s.e.m (a–c,f,g) All graphs and statistical analysis were generated using GraphPad Prism (v10) Source Data Viral shedding and RNA load in milk (n = 41) urine (n = 23) and faeces (n = 25) collected from clinical and non-clinical animals from farm 3 Viral RNA loads in milk samples collected from cattle from farm 3 on day 3 (n = 15) day 16 (n = 12) and day 31 (n = 9) post-clinical diagnosis quantified by rRT–PCR targeting the IAV matrix gene Infectious HPAI virus in milk (n = 13 on day 3 n = 12 on day 16 and n = 9 on day 31) detected by virus titration Virus titres were determined using end point dilutions and expressed as TCID50 ml−1 Source Data Haematoxylin and eosin (H&E) staining (left panels) showing intraluminal epithelial sloughing and cellular debris in mammary alveoli (Z1 and Z2) and normal mammary alveoli filled with milk and fat globules (Z3) In situ hybridization (ISH; middle panels) targeting the IAV (matrix gene) showing extensive viral RNA in milk-secreting epithelial cells in the alveoli and in intraluminal cellular debris (Z1 and Z2) and normal mammary alveoli showing no viral staining (Z3) Immunohistochemistry (IHC; right panels) targeting the IAV matrix gene showing intracytoplasmic immunolabelling of viral antigen in milk-secreting alveolar epithelial cells (Z1 and Z2) These results demonstrate a distinct tropism of HPAI H5N1 virus for the mammary tissue of cattle and the central nervous system tissue of cats with sporadic detection of virus-infected cells in other tissues in which the reassortment event culminating in the incorporation of the am8 NP segment and emergence of the HPAI H5N1 genotype B3.13 virus Phylogeny of sequences derived from cattle raccoon and grackle sampled in the farms described in this study and other sequences in closer ancestral branches Detailed view of the clade containing 91 sequences derived from animals sampled in the farms described in this study All phylogenomic analyses were conducted with concatenated whole-genome sequences suggesting that these could have emerged following spillover in cattle HPAI H5N1 virus dispersal in North America Samples described in this study are coloured by farm whereas locations in grey represent samples from closer ancestral branches obtained from the GISAID database Haplotype network analysis of HPAI H5N1 viral sequences obtained from the farms described in this study The different colours indicate different farms The size of each vertex is relative to the number of samples and the dashes on branches denote the number of mutations between nodes Phylogenetic reconstruction and analysis of dispersal between sites 1 and 2 of farm 2 (c) The directions of dispersal lines are counterclockwise All phylogenomic and dispersal analyses were conducted with concatenated whole-genome sequences The blackbirds were collected at 8–12 km away from farm 7 these results suggest both long-range and close-range lateral spread and transmission of the HPAI virus between farms These results indicate transmission of HPAI H5N1 virus between subclinically infected cows This is supported by epidemiological information revealing that feeding raw milk to farm cats was a common practice in these farms Additional historical and prospective sequence data are needed for more detailed molecular epidemiological inferences Experimental infection studies using different inoculation routes (that is intranasal versus intramammary) with the HPAI H5N1 genotype B3.13 virus and other contemporary viruses of the 2.3.4.4b lineage in dairy cattle with sequential and comprehensive sampling are critical to answer these important questions about the port of entry infection dynamics and pathogenesis in this new host species These cases highlight the zoonotic potential of the virus underscoring the need for robust measures to prevent and control the infection and further spread of HPAI H5N1 in dairy cattle This would reduce the risk of the virus adapting in this new mammalian host species thereby decreasing the pandemic risk to humans All authors of this study were committed to high standards of inclusion and ethics in research Clinical samples used in the present study were collected as part of routine diagnostic procedures and the data used for research The findings of this study are reported transparently with a commitment to accuracy and integrity All data and results are presented without manipulation and any limitations of the study are clearly acknowledged Clinical history from all nine farms were obtained from the sample submission forms sent with the samples to the AHDC Additional relevant information from each farm were obtained from attending veterinarians through investigations conducted by laboratory diagnosticians Amplification and detection were performed using the Applied Biosystems 7500 Fast PCR Detection System (Thermo Fisher) under the following conditions: 10 min at 45 °C for reverse transcription and 45 cycles of 15 s at 94 °C for denaturation and 30 s at 60 °C for annealing and extension Relative viral loads were calculated and are expressed as 45 rRT–PCR cycles minus the actual CT value (45-Ct) Positive and negative amplification controls as well as internal inhibition controls were run side by side with test samples Part of samples was also tested using 200 µl of undiluted milk and serum These samples were extracted using the IndiMag Pathogen kit (INDICAL Bioscience) on the KingFisher Flex (Thermo Fisher) and rRT–PCR was performed using the Path-ID Multiplex One-Step RT-PCR Kit (Thermo Fisher) under the following conditions: 10 min at 48 °C and 40 cycles of 15 s at 95 °C for denaturation and 60 s at 60 °C Paired serum samples collected during the acute and convalescent phase of infection from animals (n = 20) from farm 2 were used to determine seroconversion to HPAI H5N1 virus using the haemagglutination inhibition test Serum haemagglutination inhibition activity was determined using BPL-inactivated A/Tk/IN/3707/22 antigen (clade 2.3.4.4b) Haemagglutination inhibition titres are expressed as log2 values with 1 log2 being the minimum titre considered positive Virus isolation was performed in pooled milk samples from farms 1 and 2 Approximately 5 ml of milk from individual animals was pooled and a total of 50 ml of pooled milk was centrifuged at 1,700g for 10 min at 4 °C and the pellet was resuspended in 5 ml of sterile PBS–BSA (1%) followed by centrifugation at 1,700g for 10 min at 4 °C The wash step was repeated one more time and the final pellet was resuspended in 1 ml PBS–BSA (1%) Virus isolation was conducted in bovine uterine epithelial cells (Cal-1; developed in-house at the Virology Laboratory at AHDC) cultured in minimal essential medium (MEM; Corning) supplemented with 10% FBS and penicillin–streptomycin (Thermo Fisher Scientific; 10 U ml–1 and 100 µg ml–1 Cells were cultured in T25 flasks and inoculated with 1 ml of the milk pellet resuspension from infected cows and incubated at 37 °C for 1 h (adsorption) and cells were washed once with PBS and replenished with 1 ml complete growth media (MEM 10% FBS) Cells were monitored daily for the development of cytopathic effects (CPEs) infected cells were harvested and cell suspensions were collected after three freeze–thaw cycles The identity of the isolated virus was confirmed by rRT–PCR an immunofluorescence assay using anti-nucleoprotein mouse monoclonal antibody (HB65 Cell nuclei were stained with 4′,6-diamidino-2-phenylindole (DAPI; 62248 The infectious viral loads in milk and tissues of infected animals were quantified by viral titrations serial tenfold dilutions of rRT–PCR-positive milk samples and tissue homogenates were prepared in MEM and inoculated into Cal-1 cells in 96-well plates Each dilution was inoculated in quadruplicate wells and cells were fixed with 3.7% formaldehyde solution for 30 min at room temperature and subjected to an immunofluorescence assay using the anti-NP (HB65) mouse monoclonal antibody Virus titres were determined using end-point dilutions and the Spearman and Karber’s method and expressed as TCID50 ml–1 tissue sections were deparaffinized with xylene and blocked with peroxidase followed by antigen retrieval for 1 h the V-InfluenzaA-H5N8-M2M1 probe (Advanced Cell Diagnostics) and the RNAScope HD 2.5 assay were used as per the manufacturer’s instructions ISH signals were amplified with multiple amplifiers conjugated with alkaline phosphatase enzymes incubated with red substrate at room temperature for 10 min and counterstained with haematoxylin IHC was performed at the University of Georgia Veterinary Diagnostic laboratory and the USDA-ARS Southeast Poultry Research Laboratory following standard diagnostic IHC procedure tissue sections were treated with proteinase K for 5 min for antigen retrieval and incubated with monoclonal antibody to IAV M-protein (C65331M Meridian Bioscience) at 1:100 dilution (UGA and VDL) or monoclonal antibody to influenza A NP (clone 4F1; 10780-01 Southern Biotech) at 1:2,000 dilution (SEPRL) for 1 h the secondary antibody anti-mouse IgG (1070-04 Southern Biotech) at a 1:5,000 dilution was added and incubated with the slides for 1 h All the slides were counterstained with haematoxylin scanned at ×40 resolution and the digital slides were examined for virus tropism and tissue distribution Whole-blood nasal swab samples were obtained from ten cows from farm 1 in Texas Samples were submitted to the AHDC at Cornell University on 16 March 2024 metagenomic sequencing using the sequence-independent single-primer amplification (SISPA) procedure the Oxford Nanopore sequencing chemistry and GridION sequencing platform were performed as described below Sequencing libraries were generated using the Native Barcoding Kit EXP-NBD196 and the Ligation Sequencing Kit SQK-SQK109 (Oxford Nanopore Technologies) and sequenced on a FLO-MIN106 MinION flow cell r9.4.1 using the GriION platform 31 samples from farm 3 were subjected to target influenza A sequencing at the OADDL using the Illumina DNA Prep Kit and the Nextera DNA CD Indexes Paired-end sequencing was performed on an Illumina MiSeq platform using the MiSeq Reagent Kit V3 (Illumina) with 2 × 250 base-pair chemistry Other mutation data were visualized using protein consensus alignments in Geneious Prime software Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article Rapid evolution of A(H5N1) influenza viruses after intercontinental spread to North America H5N1 highly pathogenic avian influenza clade 2.3.4.4b in wild and domestic birds: introductions into the United States and reassortments Highly pathogenic avian influenza A(H5N1) virus outbreak in New England seals Infection and tissue distribution of highly pathogenic avian influenza A type H5N1 (clade 2.3.4.4b) in red fox kits (Vulpes vulpes) Highly pathogenic avian influenza A(H5N1) virus in wild red foxes Highly pathogenic avian influenza H5N1 virus infections in wild red foxes (Vulpes vulpes) show neurotropism and adaptive virus mutations Pacific and Atlantic sea lion mortality caused by highly pathogenic avian influenza A(H5N1) in South America Characterization of neurotropic HPAI H5N1 viruses with novel genome constellations and mammalian adaptive mutations in free-living mesocarnivores in Canada Influenza A(H5N1) virus infections in 2 free-ranging black bears (Ursus americanus) Naturally occurring highly pathogenic avian influenza virus H5N1 clade 2.3.4.4b infection in three domestic cats in North America during 2023 Investigation of outbreaks of highly pathogenic H5N1 avian influenza in waterfowl and wild birds in Hong Kong in late 2002 Genetic characterization of the pathogenic influenza A/Goose/Guangdong/1/96 (H5N1) virus: similarity of its hemagglutinin gene to those of H5N1 viruses from the 1997 outbreaks in Hong Kong Genetic characterization of highly pathogenic avian influenza A(H5N8) virus in Pakistani live bird markets reveals rapid diversification of clade 2.3.4.4b viruses Rapid emergence of highly pathogenic avian influenza subtypes from a subtype H5N1 hemagglutinin variant Characterization of highly pathogenic avian influenza A (H5N1) viruses isolated from cats in South Korea The changing dynamics of highly pathogenic avian influenza H5N1: next steps for management & science in North America Highly pathogenic avian influenza A(H5N1) virus clade 2.3.4.4b infections in wild terrestrial mammals Highly pathogenic avian influenza A (H5N1) virus infections in wild carnivores connected to mass mortalities of pheasants in Finland Mass mortality event in South American sea lions (Otaria flavescens) correlated to highly pathogenic avian influenza (HPAI) H5N1 outbreak in Chile Highly pathogenic avian influenza A(H5N1) virus infection in farmed minks The pandemic threat of emerging H5 and H7 avian influenza viruses Transatlantic spread of highly pathogenic avian influenza H5N1 by wild birds from Europe to North America in 2021 Intercontinental movement of highly pathogenic avian influenza A(H5N1) clade 2.3.4.4 virus to the United States USDA–APHIS. 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Preprint at bioRxiv https://doi.org/10.1101/2024.04.16.588916 (2024) Evidence of influenza a virus infection in dairy cows with sporadic milk drop syndrome Detection of antibodies to influenza A virus in cattle in association with respiratory disease and reduced milk yield Retrospective analysis of serum and nasal mucus from cattle in Northern Ireland for evidence of infection with influenza A virus Experimental infection of cattle with highly pathogenic avian influenza virus (H5N1) Divergent pathogenesis and transmission of highly pathogenic avian influenza A(H5N1) in swine Uyeki, T. M. et al. Highly pathogenic avian influenza A(H5N1) virus infection in a dairy farm worker. N. Engl. J. Med. https://doi.org/10.1056/NEJMc2405371 (2024) CDC. CDC confirms second human H5 bird flu case in Michigan, third case tied to dairy outbreak. CDC https://www.cdc.gov/media/releases/2024/p0530-h5-human-case-michigan.html (2024) Outbreak of highly pathogenic avian influenza A (H5N1) viruses in U dairy cattle and detection of two human cases — United States National Animal Health Laboratory Network. Standard operating procedure for real-time RT-PCR detection of influenza A and avian paramyxovirus type-1 (NVSL-SOP-0068). APHIS https://www.aphis.usda.gov/media/document/15399/file (2023) single-primer-amplification (SISPA) for rapid detection NanoPack: visualizing and processing long-read sequencing data Improved metagenomic analysis with Kraken 2 Metagenome analysis using the Kraken software suite Method comparison of targeted influenza A virus typing and whole-genome sequencing from respiratory specimens of companion animals Trimmomatic: a flexible trimmer for Illumina sequence data Prokka: rapid prokaryotic genome annotation Augur: a bioinformatics toolkit for phylogenetic analyses of human pathogens NextStrain: real-time tracking of pathogen evolution MAFFT multiple sequence alignment software version 7: improvements in performance and usability IQ-TREE 2: new models and efficient methods for phylogenetic inference in the genomic era TreeTime: maximum-likelihood phylodynamic analysis Leigh, J. W. & Bryant, D. POPART: full-feature software for haplotype network construction. Methods Ecol. Evol. https://doi.org/10.1111/2041-210X.12410 (2015) Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10 Posterior summarization in Bayesian phylogenetics using Tracer 1.7 Download references These authors contributed equally: Leonardo C Department of Population Medicine and Diagnostic Sciences Texas A&M Veterinary Medical Diagnostic Laboratory Ohio Animal Disease and Diagnostic Laboratory Melanie Prarat Koscielny & Ashley Johnson wrote the original draft of the manuscript The authors declare no competing interests Nature thanks Vijaykrishna Dhanasekaran, Philippe Lemey, Patricia Pesavento and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Clinically affected animals presenting clear nasal discharge and involution of the mammary gland/udder (gold arrowheads top images) and depression (bottom images) Milk from HPAI H5N1 infected animals presenting yellowish colostrum-like color and appearance (top panels) or coloration varying from yellowish to pink/brown color Hematoxylin and eosin (H&E) staining (left panels) showing; a neuronal swelling and neuronal necrosis and perivascular edema in brain (Z1 thickened alveolar septa and intraepithelial lymphocytes single cell necrosis and hemorrhage in liver In situ hybridization (ISH) (middle panels) targeting Influenza A virus (Matrix gene) showing (a) multifocal areas with extensive viral RNA (Z0) in neurons and glial cells within the granular layer and nuclear and intracytoplasmic viral RNA in neuronal soma and vascular endothelial cells in brain (Z1 viral RNA in bronchiolar epithelial cells and type II pneumocytes viral RNA in resident sinusoidal Kupffer cells and vascular endothelial cells Immunohistochemistry (IHC) (right panels) targeting Influenza A virus M gene showing immunolabeling of (a) multifocal areas of immunolabeling (Z0) intracytoplasmic immunolabeling of viral antigen in neuronal soma and axons within granular layer in brain (Z1 bronchiolar epithelial cells and type II pneumocytes in lung vascular endothelial cells and resident sinusoidal Kupffer cells Tissues from one cat were available and subjected to histological In situ hybridization of viral RNA in mononuclear cells of lymphoid follicles in lymph node mononuclear cells of bronchial associated lymphoid tissue (BALT) in the lung endothelial cells of blood vessels in the heart endothelial cells of blood vessels in the colon mononuclear cells in the spleen and endothelial cells and resident sinusoidal Kupffer cells in the liver The zoom in (Z1) represents the demarcated area in the left panels (Z0) Tissues from three cows were available and subjected to histological Immunohistochemical staining of viral antigen in mononuclear cells of lymphoid follicles in lymph node Estimation of tMRCA and immediate descendants of MRCA donors of PB2 (a) Reassortment event of PB2 and NP which lead to emergence of genotype 3.13 in an unknown host before detection in skunk The teal color of branches indicates the reassortment event Phylogenetic trees constructed with each influenza A virus genome segment comprising 91 sequences of samples described in this study and 648 sequences of samples collected throughout the American continent collected between January 2023 and March 2024 Genetic relationship of HPAI H5N1 sequences recovered from blackbirds with sequences recovered from cattle in Farms 7 and 9 Nodes are colored by premise and all the samples collected in the referred farm are highlighted Detailed/zoom in view of the sequence clusters containing samples from Farm 7 Farm 9 and sequences from blackbirds collected at 8–12 Km from Farm 7 Analysis was conducted based on whole concatenated genome sequences Close phylogenetic relationship between HPAI H5N1 sequences recovered from dairy cows Close phylogenetic relationship between HPAI H5N1 sequences recovered from dairy cows and a racoon in Farm 8 Nodes are colored by host and all the samples collected in the specific farm are highlighted Panels on the right are a detailed view of the clusters containing more than one host species This file contains Supplementary discussion that complements the discussion section of the main text RT-PCR data in CSV format showing testing results for Influenza A Matrix and H5-specific RT-PCR on all samples tested in the present study RT-PCR data in CSV format showing testing results for Influenza A Matrix and H5-specific RT-PCR on serial samples collected on days 3 Mutational analysis in CVS format showing all amino acid mutations identified in PB2 NS (NS1 and NS2) gene segments of the highly pathogenic influenza A H5N1 virus sequences obtained in the present study Predicted phenotype changes as reported through FluServer (GISAID) are also included List of sequences including GISAID accession numbers in CVS format used in the phylogenomic and mutational analyses conducted in the present study List of highly pathogenic influenza A H5N1 virus sequences obtained in the present study including GISAID accession numbers in CVS format and sample metadata (H5 clade classification Mutational analysis in CVS format showing amino acid mutations that accumulated over time and identified in PB2 NP and NS1 genome segments of highly pathogenic influenza H5N1 virus and their frequency among the available H5N1 sequences derived from cattle Download citation DOI: https://doi.org/10.1038/s41586-024-07849-4 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Maynard will leave Avanade at the end of August to join Microsoft The Avanade veteran will take the reins from Pamela Maynard who is leaving to join Microsoft’s Customer and Partner Solutions business Microsoft solutions provider Avanade has announced the appointment of Rodrigo Caserta as its new CEO Caserta has spent nearly a decade at Avanade and will step into the role from his current position as the company’s Global Technology Business Group lead the experienced leader has been credited with playing a key role in fostering a “people-first He will succeed Pamela Maynard, who will leave Avanade at the end of August to join Microsoft as chief AI transformation officer for its Microsoft Customer and Partner Solutions (MCAPS) business “It’s an honor to follow in Pam’s footsteps who brought me into Avanade nearly a decade ago,” Caserta said “The wisdom I’ve gained from her is invaluable and it’s a privilege to uphold her legacy as Avanade’s next CEO “In an era marked by complex challenges our clients have consistently found a trusted partner in Avanade I am excited and look forward to this opportunity to lead bold ambitions and a spirit of collaboration.” Drive higher sales and gain valuable customer insights Caserta has also served as Avanade’s general manager of Brazil and later as the company’s president of growth markets where he is credited with leading significant growth in both revenue and headcount across the APAC and Latin America regions as well as helping the company consistently outpace the market Avanade Board Chair and group chief executive of Accenture Technology said Caserta’s wealth of experience will help extend the company’s leading position in the Microsoft services sector Stay up to date with the latest Channel industry news and analysis with our twice-weekly newsletter “With enterprise and mid-market expertise and a deep understanding of our clients and commitment to our people he is the right person to lead Avanade as we expand market share.” Pamela Maynard will leave the business after more than 16 years’ service across various leadership positions she was appointed as CEO and went on to oversee a period of successful growth and company-wide transformation during her tenure and we look forward to continuing to work closely with her in her new role at Microsoft,” Narain added In her new role at Microsoft, Maynard lead AI transformation for MCAPS, leveraging the Redmond giant’s AI portfolio to drive both internal and customer transformation Microsoft and Avanade have been at the forefront of AI innovation with both Pam and Rodrigo playing a critical role in advancing our progress,” commented Judson Althoff Microsoft’s chief commercial officer confident in their leadership and expertise as we further strengthen the longstanding partnership between Microsoft and Avanade and pioneer new advancements in our industry.” Daniel ToddSocial Links NavigationDan is a freelance writer and regular contributor to ChannelPro covering the latest news stories across the IT A journalism graduate from Leeds Beckett University he combines a passion for the written word with a keen interest in the latest technology and its influence in an increasingly connected world He started writing for ChannelPro back in 2016 focusing on a mixture of news and technology guides before becoming a regular contributor to ITPro he has previously written news and features across a range of other topics Before Janis Joplin sadly entered the “27 Club” with her untimely death in 1970 she was a member of a de-facto clubhouse called Mnasidika a boutique clothing store in Haight-Ashbury seemed to dress every San Francisco-based band (Santana even worked out a mutually profitable relationship with Mnasidika whereby customers who’d come in to buy Peggy’s clothes could purchase a concert ticket In a 2021 interview on the Haight Street Voice podcast Peggy recalled a British man named “Chas” and a shy guitarist who stopped by her shop Chas announced he was managing the greatest guitarist in the world and asked if she could get him a meeting with Graham Why would you be asking a jean pusher and say you have the best guitar player in the world?’ I looked at this Chas [Chandler ex-bassist for the Animals] guy and the guitarist and told them ‘Sorry I can’t.’ It turned out the guitarist was Jimi Hendrix and he was the best guitar player in the world.” When musicians weren’t using Peggy for her perceived pull Peggy was pulling the wool over the clothing industry—namely Levi Strauss “One of the early hippie-ish type girls had split the side seam on her boyfriend’s Levi’s and inserted a paisley triangle.” Loving how the flared bottoms looked Peggy’s mother agreed to sew a slew of flared jeans that San Franciscans ate up faster than Owsley’s acid Peggy realized she needed a mass producer to satisfy the demand and ventured to Levi’s corporate office in San Francisco her meeting with a highbrow higher-up did not go well ‘You know we have the best-selling jeans in the world and you come here and think you have a better idea?’ And when he was showing me the door came walking down the hall and I was in a mini-skirt and fifteen pairs of beads around my neck and he yelled at me ‘Girly girl!’ And today you couldn’t get away with that and I thought ‘Yes sir?’ And he asked me what did I want and the rest is bellbottom history That man took a chance on me but then I thought Levi’s gave her a six-month exclusive on the new line which made Peggy a millionaire most of the money went to heroin—as it did with her new friend “The Grateful Dead lived at 710 Ashbury Street I had opened my window and she was opening hers at the same time ‘Hiya honey!’ with her southern inflection Seeing and hearing Janis sing later that night with Big Brother and the Holding Company was mind-altering.” Looking back at their four-year relationship, Peggy revealed to New York Magazine’s Vulture blog in 2018: “I loved her But to be her lover was to resign yourself to being invisible and as hard as it may be for people to understand now the couple cut a wide swath of self-destruction didn’t show up for a planned sex and drug-filled night with Janis at the Landmark Motor Hotel who insisted in her autobiography that Janis died from breaking her nose and suffocating on her blood after falling in her room continued running into self-made trouble that included agreeing to write with Dan Knapp Going Down With Janis (A Raw and Scathing Portrait of Janis Joplin by Her Female Lover) Peggy shot up in a restroom then groggily answered Knapp’s questions which resulted in a tawdry memoir that she never lived down “I sold out [$2,000] for drug money and I’ve lived in the shadow of it for 40-some-odd years The ‘collaborator’ filled in what he didn’t know and the editors bypassed showing me the final text Perhaps I had signed away that right in my drugged haze.” culminating in a two-year prison stint for possessing heroin When Peggy wasn’t cooking smack in a spoon Two of her seedy crew wound up in a prison that allowed conjugal visits so Peggy joined them in the jail where she helped her pals dig a tunnel and escape “The End” of Peggy’s cinematic-like life occurred on November 21 She left behind a cabin in Tillamook County Oregon and enough entertaining anecdotes to fill a TV series The pilot episode should open with Janis driving her friend through Hollywood Janis parked in front of Frederick’s of Hollywood and dashed in to buy lingerie only to return and tell Peggy the store wouldn’t accept a check from the singer because she wasn’t carrying any form of I.D Problem-solving Peggy pointed to a newsstand that featured Joplin on the cover of Newsweek’s May 26 Janis presented the magazine to the sales staff and bought a bagful of lingerie then got an earful from Peggy because she was stoned and driving without a license—but at least Janis created a novel and new form of identification Mark Daponte is a copy/blog writer for an advertising company and has published/sold four short stories nine short screenplays (including two animation scripts) and punches up screenplays—because they don’t punch back He has had six short comedic plays performed by various theater companies When he isn’t sinking down to a thirteen-year-old’s level to make his teenaged sons laugh he can be found seeking signs of intelligent life in his hometown of Brooklyn Δdocument.getElementById("ak_js_1").setAttribute("value",(new Date()).getTime()) Peggy doesn’t sound like the gal you’d take home to meet the parents And Jimi Hendrix wasn’t the greatest guitarist in the world…nobody ever knows who that is who told the world about her relationship with Joplin in a revealing memoir in 1973 entitled Going Down With Janis passed away at her Oregon cabin on November 21st Her death has been announced by her friend and publisher While Caserta would later dispute her own claims in the memoir by denying that there was ever a romantic relationship between her and Joplin her stories candidly told of the singer’s life before her tragic death in 1970 at the age of 27 with revelations about her sexuality and drug use being heavily discussed which Caserta later asserted was ghostwritten by another author and that her only contributions were made to help fund her heroin addiction was met with both fierce criticism and praise at the time it was viewed as scandalous and sensationalist but others called it an important piece of writing that covered Joplin’s bisexuality in a way that was uncommon for its time In a later 2018 memoir entitled I Ran Into Some Trouble Caserta revisited many of the claims she had made in her initial publication stating that many of the stories were fabrications of the truth while also claiming that Joplin did not die of an overdose but instead asphyxiated on her own blood after an accidental fall Much of Caserta’s documentation of Joplin’s life has been used as source material for other retellings with the 1979 Bette Midler film The Rose being an unauthorised fictionalisation based on the stories that Caserta had previously told in her memoirs Caserta also advised the filmmaker Peter Newman with information for the lengthy production of his biopic Janis which has been in the works for over 20 years During her life, Joplin recorded four studio albums, two of which were with her band Big Brother and the Holding Company and the latter two recorded alongside other backing bands. Following her death, Joplin would go on to be regarded as one of the greatest vocalists of her generation and has continued to have a shining and influential legacy Joplin was inducted into the Rock and Roll Hall of Fame alongside Neil Young and was also posthumously recognised in 2005 with a ‘Lifetime Achievement Award’ by the Grammys Ivy Lerner-Frank Sundays are crowded at Little Italy’s Alati-Caserta but there are worse things than waiting in line while gazing at the tiered cakes in the display window This bakery across from the famous Madonna della Difesa church has all the classic Italian treats you might not see elsewhere: savory taralli We come here all through the year for their chewy amaretti and pistachio cookies by the pound there’s nothing like devouring a cup of their lemon granita in Parc Dante across the street Bakery/Cafe Park Ex Pâtisserie Afroditi is a Park Ex bakery that’s been open since the ’70s Little Italy Boulangerie Marguerita has been in the same location for over 100 years Côte-des-Neiges French bakery Duc de Lorraine is a 70-year-old French bakery on a busy corner of Côte-des-Neiges Ahuntsic has been making pistachio-studded Middle Eastern sweets for the past 50 years Overcoming some limits was one of your goals: how did it go? "He was referring above all to a more mental limit. My wealth of experience sometimes created difficulties for me because I tended to make comparisons with myself and instead of giving me confidence it brought me down, creating limits that weren't there. It's important to work on the mental approach as well as the physical one." Caserta out of the tub? "I could be named the custodian of the Reggia, since I went there almost every day for a walk. I found people who I can say are true friends, who cheered me up during the periods when training was tougher. Imola is obviously home, but so is Caserta and when I have the chance I will return there". What has Imolanuoto found? "I left young boys and girls who are now more mature, I think especially of Simone Cerasuolo who has grown a lot. Then there are new people from outside, a sign that Imola has become a great center to train, and I found Cesare Casella always super attentive to everyone's needs". She will be among the veterans of the group. "I don't know if I have this calling, but I'm happy to lend a hand if someone needs it. In my time I looked up to the greatest and I think this has great value. We can teach today's youth a lot." She says "The youth of today." As if she were old... "Well, I'm 30 years old, even if I still feel like the 2010-year-old who won my first title in XNUMX. But from a mental point of view I feel tired, in addition to some physical ailments." Future plans? "I'm aiming for the Sette Colli and a few meetings in between, hoping that my condition will return to its best and that I will recover physically." CASERTA (Lega A) - Pepsi Caserta had home-court advantage but Armani Jeans Milano won a deciding fifth game in their Lega A play-off semi-finals on Thursday night.\r\n\r\nMason Rocca had 14 points and 11 rebounds as Armani Jeans won 65-59 to set up a title showdown with three-time defending champions Montepaschi Siena.\r\n\r\nSiena swept Milano 4-0 in last year's ... Mason Rocca had 14 points and 11 rebounds as Armani Jeans won 65-59 to set up a title showdown with three-time defending champions Montepaschi Siena Siena swept Milano 4-0 in last year's .. Le staffette maschili italiane puntano a Singapore con la staffetta 4×100 stile da definire e le carte in regola per qualificare la 4×200 e 4×100 mista Lo stile libero veloce maschile si divide tra nuotatori esperti come Alessandro Miressi e Filippo Megli e i nuovi talenti 18-year-old Carlos D’Ambrosio has broken the Italian record in the SCM 200 freestyle 17enne delle Fiamme Gialle firma a Riccione un 1’41.61 nei 200 stile libero: è il nuovo record italiano assoluto Stati Uniti e Australia hanno dominato i Mondiali del 2022 gli atleti neutrali russi si uniranno alle danze per le staffette maschili Inizia a nuotare nel Gruppo polisportivo Catanzaro dove si allena da allora nel polo della velocità con il tecnico federale Claudio Rossetto Oltre a importanti risultati durante la sua carriera giovanile vanta un bronzo alle Universiadi 2023 di Chengdu sui 200 metri stile libero In occasione del Settecolli di Roma a Giugno 2024 con il primato personale di 1:46.88 nei 200 stile conquista la convocazione per i Giochi olimpici di Parigi dove disputerà la staffetta 4×200 stile libero maschile Subscribe to our newsletter and receive our latest updates “We are pleased to announce that the Max Mara Resort 2026 collection will be showcased on Tuesday former royal residence and Unesco World Heritage Site,” the house said in a news statement The palace is a former royal residence in Caserta located 35 km north of Naples in southern Italy Join our VIP Club for exclusive giveaways and members only events Luxury fashion house Max Mara has officially revealed the breathtaking location for its highly anticipated Cruise 2026 collection: the Royal Palace of Caserta. Nestled just outside Naples often compared to France’s Palace of Versailles promises to be the perfect backdrop for the brand’s latest vision of refined elegance With a history steeped in grandeur and artistic brilliance this UNESCO World Heritage Site will set the stage for a show that blends timeless Italian craftsmanship with modern sophistication Following last year’s show at the Palazzo Ducale within Piazza San Marco in Venice Max Mara continues its tradition of hosting resort collections in culturally rich and historically significant locations an estate originally commissioned by Charles VII of Naples in 1752 as the official royal residence Designed by legendary architect Luigi Vanvitelli the palace boasts 1,200 rooms across five floors an opulent theater inspired by the Teatro di San Carlo in Naples and sprawling Baroque gardens that stretch over 11 acres For Max Mara, a brand synonymous with refined tailoring and understated luxury this historic location is a fitting choice The palace’s blend of Baroque and Neoclassical design mirrors the brand’s commitment to timeless elegance — where heritage meets modernity in seamless harmony Cruise collections have long been a staple for luxury fashion houses Originally created for jet-setting clientele escaping to warmer destinations these collections now serve as a pivotal moment for brands to showcase their vision outside the confines of traditional fashion weeks and immerse fashion lovers in unique storytelling experiences staging its Cruise 2026 collection in Caserta is more than just a runway event — it’s a statement The grandeur of the Royal Palace aligns with the brand’s enduring dedication to craftsmanship is expected to highlight Max Mara’s signature sleek silhouettes and the effortlessly chic aesthetic that has defined the brand for decades Max Mara’s decision to showcase its collection at Caserta underscores the growing trend of fashion intersecting with cultural preservation luxury brands have increasingly sought out historically significant venues not only to provide stunning visuals but also to celebrate the artistry embedded in these architectural masterpieces often regarded as one of the most ambitious and grandiose palaces in Europe and intricately decorated halls will serve as a captivating stage merging fashion and history in a way that resonates with the modern luxury consumer While the exact details of the collection remain under wraps, fashion enthusiasts can anticipate a showcase of expertly crafted pieces that embody Max Mara’s signature aesthetic the brand is likely to present an array of effortlessly elegant looks that align with the setting’s royal grandeur Max Mara’s Cruise 2026 show is not just a celebration of fashion — it’s an ode to Italian heritage and a testament to the brand’s ability to weave history into modern-day luxury where past and present will collide in a spectacle of style Mark your calendars for June 17 — this is one fashion moment you won’t want to miss Reproduction in any manner in any language in whole or in part without the prior written permission is prohibited Registration or use of this site constitutes acceptance of our Terms of Service Peoply may receive compensation for some links to products and services Offers may be subject to change without notice the Reggia di Caserta will host a new exhibition by Michelangelo Pistoletto (Biella one of the most significant and prolific figures in contemporary Italian art a leading figure in the radical renewal of artistic language and theArte Povera movement entitled Metawork and curated by Tiziana Maffei takes its name from the work Metawork-United Portraits presented for the first time on this occasion.This work stems from photographic portraits of eight Cittadellarte citizens subsequently reworked through an artificial intelligence program in a process that recalls the transition from the personal to the collective dimension as was already the case in the famous Quadri specchianti produced by the Reggia di Caserta Museum in collaboration with Opera Laboratori Cittadellarte - Fondazione Pistoletto and Galleria Continua offers a deep immersion in the themes of metamorphosis and interconnectedness central to the Biella artist’s vision Prominent among the themes is the link between art and spirituality is presented as a symbolic temple that brings together the main monotheistic religions-Christianity Each faith is represented through a symbolic element placed in front of a mirror: a kneeler Pistoletto’s art is distinguished by its dialogic approach oriented toward exchange and confrontation It is an ever-evolving quest to re-establish an authentic connection between the art world and everyday life taking art outside its boundaries and integrating it into the human experience Pistoletto presented at the Venice Biennale the project Love Difference - Artistic Movement for an Intermediterranean Politics represented by a large mirrored table modeled on the shape of the Mediterranean surrounded by chairs from the countries bordering this sea he made the first permanent installation of the Love Difference slogan with neon lettering in different languages on the facade of the multi-ethnic market in Turin’s Piazza della Repubblica represents a synthesis of Pistoletto’s political and artistic vision as expressed in his 2002 manifesto: “Uniformity and difference are antagonistic terms that reflect the deepest conflicting tension of global reality A politics that teaches to love differences is essential for new social perspectives.” Naked Mass of 2020 portrays human figures without clothing while the series Division Multiplication-Third Paradise reflects on the tension between nature and artifice The latter is developed through eight pairs of mirrors on which appears the symbol of the Third Paradise a reworking of the mathematical sign of infinity where a central third circle represents the womb of a new humanity the ideal outcome of the synthesis between the two opposite poles Other mirror works in the exhibition include QR Code Possession - Self-Portrait in which twelve QR codes tattooed on the artist’s body refer to key moments in his production which reworks Michelangelo Buonarroti’s iconic Creation of Adam creative generation does not occur from contact with the divine hand but emerges from the human hand alone through the mirroring device QR Code Possession - The Formula of Creation Meetings (2023) presents twenty canvases that lead to discussions about the book The Formula of Creation between the artist and personalities from various fields Also on view in the Grand Gallery is Labyrinth first presented in his solo show at the Boymanns Museum in Amsterdam in 1969 “The labyrinth is a highly symbolic place The legend of the Minotaur stands for the monster that lives within us and the possibility that all of us at some time in our private lives or in our collective lives My labyrinth is made of corrugated cardboard a flexible material that allows it to take any shape and fit into any space In a sense it is like the mirror that accommodates any image It presents itself as a physical element that is at the same time strongly linked to the imagination,” said Pistoletto “An important exhibition that in its multiplicity enhances multiple themes consistent with our museum mission,” says Tiziana Maffei curator of the exhibition and director of the Reggia di Caserta - The red thread is with Terrae Motus that constantly brings the Reggia back to the steps of contemporaneity with the artists involved The attention to dialogue and art-in this place that is the space of an international diplomacy founded on cultural confrontation experimentation and innovation-find here a persistent reference it is a metaphorical tribute to the work that the Reggia carries out with commitment releasing material creative technical energy on a daily basis I thank Master Michelangelo Pistoletto and the different actors in this operation for taking up the invitation of the Reggia The Grand Gallery space thus continues its journey in content construction by expanding its cultural offerings in a rich system of relationships." A visit to the exhibition is included in the cost of a ticket/subscription to the Reggia di Caserta Museum The Royal Palace of Caserta is expanding its museum offerings: throughout the fall and winter the Court Theater will open almost every day with more extended hours and arrangements than usual despite the museum’s very serious staff shortage.The Court Theater of the Royal Palace of Caserta inaugurated on the occasion of the visit of the new Queen Maria Carolina is a jewel of 18th-century theatrical architecture acoustic quality and sumptuousness of its decorations Work on the palace had already been underway for a few months when King Charles of Bourbon asked architect Luigi Vanvitelli to build it located in buildings off-center from the central core of the royal residences this space is inserted in one of the bodies of the Reggia and perfectly integrated into the system of pathways it is located in the center of the western side of the Palace It has a horseshoe shape with five tiers of boxes The frescoed vault with Apollo trampling the serpent Python An element that characterizes the theater scene is also the possibility of using the green area behind it as a natural backdrop The expedient was devised in 1722 on the occasion of the performance of Pietro Metastasio’s Dido Abandoned which involved the burning of the city of Carthage: an opening was opened on the wall behind the stage with a view of the Malalocata garden The Court Theater will be open (except for free days when it will be closed): - and on Saturdays and Sundays (thanks to the collaboration of the Italian Touring Club) from 10 a.m - and on Saturdays and Sundays (thanks to the cooperation of the Italian Touring Club) from 10 a.m - and Saturdays and Sundays (thanks to the collaboration of the Italian Touring Club) from 10 a.m The visit to the Court Theater is part of the cost of the Museum ticket/subscription June 1, 2022McKinsey’s acquisition of Caserta is our latest move to further strengthen our data capabilities and become our clients’ leading technology impact partner, bolstering our work in data strategy and design “We are on a journey to become the world’s leading impact partner for technology,” says Aamer Baig, McKinsey senior partner and North American leader of McKinsey Technology “This acquisition creates a significant opportunity to help clients overcome the challenges in building competitive industry-leading enterprise data environments.” Our relationship with Caserta began more than a decade ago; they helped build our internal knowledge management platform when a client enlisted Caserta to bring its data assets to the cloud we partnered with Caserta to help a financial services client launch a new business offering data and analytics software to a new market Caserta mobilized improvements in the performance and stability of their cloud-based data infrastructure improved the pace at which new features could be launched and began coaching and developing the client’s engineering team The data-driven enterprise of 2025Rapidly accelerating technology advances and increasing data literacy are changing what it means to be “data driven.” “The teams at Caserta want to work on challenging, cutting-edge problems, and they want their work to have impact for businesses—and their employees, particularly through capability building,” says Kayvaun Rowshankish McKinsey senior partner and global co-leader of the firm’s Data Transformation Practice “Unlike a lot of other data engineering shops which tend to want to build code and get out Caserta is more focused on long-term impact considered a visionary and pioneer in the data-engineering space Caserta has established a stellar reputation having designed and implemented cutting-edge data architectures for many Fortune 100 companies They have built and created cloud native data lakes and pioneering thought leadership in metaverse data engineering they helped a leading music streaming service build out the complex cloud platform crucial to its operations McKinsey was the model I used to stay laser-focused on positively impacting the goals of our clients,” says Joe “There is nothing more exciting as a CEO of a tech consulting firm than building a business around solving uniquely complex problems having our teams get completely immersed in issues that matter actionable solutions that launch our clients into success.” Caserta has created a unique approach to solve the most complex data engineering challenges They use a proprietary method of linking business needs into tailored data architecture designs This acquisition creates a significant opportunity to help clients overcome the challenges in building competitive industry-leading enterprise data environments “Data is integral to every transformation that’s happening across sectors and geographies in the next three to five years It’s the competitive edge most firms will be creating and defending and an area where we will see the greatest innovation,” says Kayvaun “The combination of McKinsey and Caserta will position us to play a pivotal role in moving industries to the next stage of technology transformation.” Caserta enhances how we can work with clients on data strategy and design They strengthen our ability to deliver end-to-end data transformations and talent to implement cloud data architectures at enterprise scale all of which is core to our clients’ digital and analytics development “Having Caserta join McKinsey allows us the opportunity to solve more comprehensive data challenges and have a significantly elevated role in advancing businesses and society with data,” says Joe “I am very excited to apply our joint efforts to creatively and deliberately improve lives and businesses around the world.” The year 2024 marked a year of transformation for the Royal Palace of Caserta a symbol of Italian cultural heritage and a UNESCO site: the institute now makes it known that 2025 opens with renewed prospects under the banner of the continuation of that structural plan that has already been launched and that aims to improve the quality of services A tangible and already achieved example of this commitment is the return to the public of spaces of extraordinary value such as thewest wing of the royal palace and the Graefer Greenhouses the first example in Italy of a public-private partnership applied to a historic garden.The year 2024 began with a historic event: the visit of the President of the Republic Sergio Mattarella to inaugurate the Grand Gallery a moment that moved the entire staff of the Museum a series of initiatives punctuated the year such as “Visions,” Danilo Ambrosino’s “In the King’s Garden,” Marco Bagnoli’s “The Stone the Sun Reveals,” and “Metawork - Michelangelo Pistoletto at the Royal Palace of Caserta.” fundamental works for the preservation and revitalization of the complex have been initiated such as the renovation of the facades and roofs and the opening of a new access in Corso Giannone The Royal Park also benefited from plant heritage studies and resurfacing of the waterway avenues the Royal Palace has had to contend with serious critical issues This has necessitated judicious management with restrictions on access during free days and constant monitoring to avoid losing important funding and ensure the regular opening of museum spaces the Museum experienced significant growth in the number of subscribers and school visitors over 106 thousand and 116 thousand admissions valuable collaborations were activated such as those for the “Queens Jam,” “OroRe” wine and the “Masters at the Reggia” project The Royal Palace of Caserta is thus preparing for a 2025 full of challenges but also opportunities Ongoing projects include the redevelopment of the Passionist Complex with “Reggia in art and design” and the strengthening of international relations as demonstrated by the Technical Meeting of European Royal Residences hosted this year the complex is confirmed as a cultural and tourist landmark Behind every milestone achieved is the tireless work of a dedicated team with the common goal of honoring Luigi Vanvitelli’s vision wants to design a future of growth and innovation for a place that is a symbol of Italian heritage When most Aussies enter a racehorse into their Blackbook they have dollar signs in their eyes as they ponder a punting windfall But when Matt Caserta gets a Blackbook notification that Far Too Easy is about to race, special memories of his adored twin brother Chris come flooding back Far Too Easy, a well-fancied contender in Saturday's $2m The Kosciuszko on Everest day at Randwick, has a unique place in the heart of Melbourne carpenter Matt. Matt was there when the horse bolted in at its first start at Grafton in June 2021 driving his much-loved jockey brother Chris to the races and cheering from trackside He remembers fondly how his brother, who tragically drowned during a fateful Surfers Paradise swim later that year, thought the world of David McColm's horse Matt Caserta (left) and his late twin brother Chris • ‘JEN AIR': Ottobre's bold plan to buy jet for racing \"I went and watched Chris ride the horse the first time and when we were driving back after the race Chris said he had this gut feeling it was going to go on to much bigger and better things,\" Matt Caserta told Racenet \"I have this horse Blackbooked in my phone so I get a notification every time it races \"And that's purely because of what Chris told me that day \"I'm not as much into the racing scene as I used to be when Chris was around \"I will 100 per cent watch The Kosciuszko on Saturday and I'll be cheering this horse for Chris.\" Chris Caserta riding Far Too Easy in his debut win at Grafton in June 2021 Picture: Grant Peters/Trackside Photography the unspeakable tragedy in late 2021 was also mixed with incredible joy Two days before twin brother Chris passed away Matt Caserta became a father for the first time Leonardo Matteo Christopher Caserta came into the world but the joy of a newborn was soon spliced with terrible tragedy trying to be happy and joyous about the birth of my first kid but then Chris passed away \"Everything that happened with Chris and trying to juggle my emotions with a newborn and the timing of it is a blur \"Chris never got to meet my son and we have since had a daughter (Sofia) who he never got to meet either \"So for him to never get the chance to meet my son and my daughter \"Chris and I did taekwondo and martial arts together and we used to teach classes with kids \"The kids always loved Chris and he always loved them.\" Caserta celebrating Far Too Easy's first win with trainer David McColm Before his young life was cut short at age 26 Chris Caserta was a pint-sized jockey who rode 154 winners The Casertas weren't a racing family before Chris Chris Caserta had moved from Victoria to Queensland to get more opportunities as a jockey and Matt is certain if his brother was alive today \"Chris came from a non horse racing background and it gave him more motivation and more drive to get to the top,\" Matt said Matt Caserta (top) and his late twin brother • WATCH: Trainer-turned-karaoke king is coming to a pub near you he really settled himself down and he got his mind in the right head space \"We used to watch his races replays all the time and I really cherished doing that \"My birthday doesn't really feel like a birthday anymore \"I have had two birthdays since Chris passed and it's obviously not the same anymore.\" After Caserta rode Far Too Easy to its first two Grafton wins he told his manager at the time Garry Legg that the young horse was so good it could even win a Group 1 Newmarket Handicap in Melbourne Caserta told anyone who would listen how talented the horse was Matt Caserta and his young son Leonardo Christopher Caserta Far Too Easy has won more than $1.3m in a career which has been interrupted by deadly floodwaters raging through his Murwillumbah stables and some serious medical issues Racenet reported last month that Far Too Easy had been so sick with colitis earlier this year that his tearful trainer McColm hugged his favourite horse and said a final goodbye The now six-year-old gelding made an incredible return to racing at Eagle Farm last month and trainer McColm is convinced he has got him on song to score the rich Kosciuszko prize After finishing third and second in the last two runnings of The Kosciuszko it really would be a racing fairytale if Far Too Easy could score on Saturday And there won't be a dry eye in the Caserta house But when Matt Caserta gets a Blackbook notification that Far Too Easy is about to race, special memories of his adored twin brother Chris come flooding back Far Too Easy, a well-fancied contender in Saturday's $2m The Kosciuszko on Everest day at Randwick, has a unique place in the heart of Melbourne carpenter Matt. He remembers fondly how his brother, who tragically drowned during a fateful Surfers Paradise swim later that year, thought the world of David McColm's horse • ‘JEN AIR': Ottobre's bold plan to buy jet for racing "I went and watched Chris ride the horse the first time and when we were driving back after the race Chris said he had this gut feeling it was going to go on to much bigger and better things," Matt Caserta told Racenet "I have this horse Blackbooked in my phone "And that's purely because of what Chris told me that day "I'm not as much into the racing scene as I used to be when Chris was around "I will 100 per cent watch The Kosciuszko on Saturday and I'll be cheering this horse for Chris." "Everything that happened with Chris and trying to juggle my emotions with a newborn and the timing of it is a blur "Chris never got to meet my son and we have since had a daughter (Sofia) who he never got to meet either "So for him to never get the chance to meet my son and my daughter "Chris and I did taekwondo and martial arts together and we used to teach classes with kids "The kids always loved Chris and he always loved them." "Chris came from a non horse racing background and it gave him more motivation and more drive to get to the top," Matt said • WATCH: Trainer-turned-karaoke king is coming to a pub near you "We used to watch his races replays all the time and I really cherished doing that "My birthday doesn't really feel like a birthday anymore "I have had two birthdays since Chris passed and it's obviously not the same anymore."