discusses the specific substudies included in myeloMATCH professor of medicine at Duke Cancer Institute and co-chair of the myeloMATCH Senior Science Council a trial representing a significant shift in how acute myeloid leukemia (AML) is treated by addressing the disease's complexity and genetic diversity 0:09 | In order to improve outcomes for [patients] with acute myeloid leukemia and myelodysplastic syndromes [MDS] it is critical that we understand the heterogeneity of this patient population in terms of the drivers of the disease pathogenesis We have a lot of information about the mutations that are present in patients with AML and MDS 0:37 | Out of the 10s of 1000s of genes in each of our cells that are currently mutated in people with acute myeloid leukemia We truly believe that these mutations underlie a pathogenesis of the disease We have already started to make great inroads into the treatment of acute myeloid leukemia by identifying some of these targets 1:27 | Some of the targets identified are more common like FLT3 Other mutations are now targets for other therapies such as the Menin inhibitors and patients with NPM1 mutations and KMT2A myeloMATCH attempts to identify these mutations at the time of diagnosis and then assign patients to clinical trials meant to optimize the initial therapy and then subsequent therapy for these patients based on this mutational analysis and we already have patients accrued to the study The idea here is that after a patient is screened and the genetic profile is defined the patient will then be assigned to an appropriate study we plan to have studies for every subtype that we identified and plan to develop studies for new targets that are identified myeloMATCH is activating with 2 studies: 1 from the Canadian Cancer Trials Group in intermediate-risk AML as defined by [European LeukemiaNet (ELN)] 2017 criteria or average-risk karyotype AML as defined by ELN 2017 and those studies are coming for the initial treatment of younger patients with acute myeloid leukemia We are doing a similar thing for older patients identifying these mutations and then developing trials Stay up to date on practice-changing data in community practice RP1 and the Future of Oncolytic Therapy in Melanoma MBBS discussed the mechanism of action of RP1 the design and preliminary findings of the IGNYTE trial in melanoma Higher ctDNA Serves as Early Warning for Melanoma Recurrence Risk discussed a study showing ctDNA levels before melanoma treatment strongly predict recurrence and its speed potentially guiding future therapy decisions CBT Benefits Cancer Patients' Mental Health & Treatment Adherence discussed how cognitive behavioral therapy helps cancer patients manage emotional challenges by modifying negative thoughts and behaviors Study Indicates Early Resolution of CRS, Neurological Events After Axi-Cel discussed a study on cytokine release syndrome and neurological events post axicabtagene ciloleucel in large B-cell lymphoma New Standard of Care? KEYNOTE-689 Results in LA-HNSCC which investigated pembrolizumab in locally advanced head and neck squamous cell carcinoma Confronting Prostate Cancer Misinformation in the Digital Age discussed a study analyzing prostate cancer misinformation on social media 609-716-7777 Albanian fashion designer Erba, or @style_by_erba on Instagram has accomplished quite a bit at just seventeen years old Erba’s designs are eye-catching and beautiful Her Instagram account boasts not just the designs themselves but also her musings on what inspired each piece She explains her thought process around designing and where she sees her brand @style_by_erba at 14; what drew you to designing clothing at such a young age? At the age of 14 I felt a strong pull towards the world of fashion and style I've had a deep interest in art and creativity and clothing became my way to express the ideas and passion I had for bringing something fresh into the fashion world it was an opportunity to create something that could impact how people feel and look This natural passion for style and creativity drove me to start this path at such a young age especially with the new opportunities that modern technology gave me to share my creations with the world What inspires your design process when creating a new piece?My design process is inspired by a variety of factors Every everyday detail can be a source of inspiration—a particular color I see in the sun or even the emotions people express through their clothing style every collection I create is a story I want to tell I like to use light colors and combine different materials to create something that is unique and memorable Inspiration can also come from my travels and from meeting people who have special stories I am fully dedicated to each creative process and always try to bring something new that I feel fits the modern world but also maintains a special element that is only mine Who do you imagine to be the target audience for your designs?The target audience for my designs are people who are passionate about fashion and who want to express their identity through clothing They are also those who are looking for styles that are modern but have a unique touch and that break away from traditional norms they are those who feel confident and empowered when wearing something that makes them look different and that reflects their unique personality I want my designs to be for those who look for quality but also for those who are willing to dare and try something new my audience is for those who are open to change and want to feel special Do you have a designer other than yourself that you look to for inspiration I certainly have some designers that I admire and who inspire me Her extraordinary creativity and innovation in the field of fashion along with the use of unexpected and extraordinary elements Schiaparelli was one of the greatest designers who challenged the norms and brought a fusion of art and fashion that was radical for the time She was known for her work with surrealism and collaborations with famous artists such as Salvador Dalí and Jean Cocteau I also admire other designers such as Dior and Vivienne Westwood who have brought a new spirit to the fashion industry and have created collections that have had an impact and that have remained timeless my inspiration does not only come from big names inspiration can also come from ordinary people that I see every day—from their unique styles and the way they express themselves through their clothing How would you describe your own personal style? My personal style is a mix of elegance and boldness I like to experiment with different shapes and colors but always maintaining a refined aesthetic I always try to bring a unique element that reflects my personality and the feelings I want to express I like to create clothes that are both simple and distinctive Another part of my style is the dedication to quality and details; I believe that details make the difference and are what give character and life to any outfit The use of accessories and small additions as they can provide an instant change and can attract attention Does your style when designing differ from the way you dress yourself day-to-day?Yes there is a difference between my personal style and what I create for my followers I like to experiment and create something special that can express new and bold ideas My collections are often bolder and more refined because I want to create clothes that can challenge and convey a strong message I often prefer a simpler and more comfortable style but I always maintain elegance and an individual touch that reflects me I like to combine fashion elements with the practicality of everyday life creating a look that is both refined and functional Are there any other ways you express yourself creatively in your everyday life?Yes I have always wanted to express my creativity in many forms and I often enjoy experimenting with colors and shapes on paper interior design is another way to express myself – I like to create spaces that are functional and aesthetically appealing using shapes and colors that reflect my passion for design Music is also a big part of my life – through it I feel I can express feelings and emotions that I cannot capture in the form of visual art or design I enjoy listening to a wide range of genres and this helps me to relax and find inspiration for my work I think that any art form or activity can bring some kind of inspiration that we can use to enrich our creativity How do you balance your dedication to fashion with your other commitments as a 17 year old?For me but I always try to organize my time so that I can devote myself to both fashion and other aspects of life but I also make sure that I have time for myself and for activities that inspire me I try to work on them on the weekends or after school I know that it is important to maintain a balance so I also try to engage in activities that help me relax such as music or helping with other art-related projects It is important to be disciplined and be able to manage my time efficiently and for this I have support from family and friends Have you ever been told that you’re too young I have had comments from time to time that I am too young to have a big impact in the fashion industry or that I cannot be serious because of my age I have great self-confidence and have always believed that age is just a number This is a dream of mine and I have great discipline and dedication that will lead me to its realization I believe that with the passion and dedication that I have “ERBA” will become an international brand that will recognize successes on a global level it is important not to let any obstacle stop me and to keep moving forward because I think that young people are often the ones who bring change and challenge the status quo with new ideas and works What has been the highlight of your career thus far?The highlight of my career so far has been collaborating with Living magazine here in Albania an opportunity offered to me by Editor Santana Comora This was an unforgettable moment and a great recognition for my work as the magazine has managed to be clicked by more than 500K+ people but it also gave me the opportunity to reach a very wide audience I also had the opportunity to collaborate with renowned illustrators and fashion designers and this has contributed greatly to the development and growth of my brand Seeing my work being appreciated and distributed on such a large level was a very special feeling and has increased my confidence to continue with passion and dedication in developing my brand How do you see yourself continuing to evolve as a designer What do you think is next for you?As a designer I see myself continuing to evolve and grow through the experiences and lessons I learn along the way My passion for fashion is always growing and I have learned to be more daring and experiment with my style I aim to develop collections that suit different tastes and that incorporate innovative techniques and materials My future as a designer will include growing my brand “ERBA” making it an international and well-known brand I also want to engage in more collaborations with other designers and brands as well as explore new opportunities in the fashion industry including collections for future seasons and the development of different lines such as those for everyday wear and accessories and the future holds endless possibilities for experimentation and creation Do you have any major goals for your involvement in the fashion world in the future? Yes I have big goals for my future in the fashion industry One of my main goals is to develop and create my own brand an international and globally recognized name I have a vision to create collections that are sustainable attractive and that adapt to the needs and desires of people from all over the world I want to experiment with new techniques and materials that can bring innovation to the fashion industry while also trying to ensure that each collection I create has a strong message and a unique identity another important goal is to engage in collaborations with internationally recognized designers and brands to share my vision and bring new and fresh fashion to the world one of my main goals is to continue my studies at the University of Fashion Design to deepen my knowledge and further develop my professional skills I believe that education is a very important step to create a sustainable and successful career all I want is to make a positive impact on the fashion industry by creating something that is beautiful My dream is for people to feel empowered and inspired by the clothes I create and for “ERBA” to be a name associated with quality is a step towards achieving these big goals and I am fully committed to going all the way to make them happen.” Interview by Logan Dutra, Contributor, PhotoBook MagazineTearsheets by Robin Chou PhotoBook Magazine's mission is to integrate the creative world with a supportive and healthy environment embrace positive well-being and sustainable fashion All images and content are the copyright of PhotoBook Magazine, our contributors, or the company/individual we featured. Please contact us if you are interested in using any of our content Photo by: Scobel Wiggins/Oregon State AthleticsOregon State Q&A: Mia Erba July 08 When out and about in Los Angeles, the subject of cannabis will likely come up. More specifically, where to shop for the best deals, the best quality, and the best delivery times. No matter where you are, ERBA weed dispensary offers that It has stores in three strategic locations making cannabis shopping anywhere in the city as easy as buying bread and milk Cannabis shopping can be confusing even for the most experienced among us ERBA opened three marijuana dispensaries in specific locations This ensures access to quality cannabis for as many people as possible Since its delivery network for all three stores stretches citywide ERBA dominates the cannabis market in West Los Angeles it offers a menu superior to all others anywhere it services a large slice of Los Angeles with the finest bud money can buy Its delivery network connects people far and wide bringing togetherness to its local cannabis scene New products enter the legal marketplace in record numbers every month from weed itself to the tools and accessories to use it Buds are the most popular at all ERBA stores This is predominantly the reason for their sellout status Edibles promise a healthy alternative to smoking Products are increasingly innovative and the buzz very worth it everything comes available infused these days They make famous beauty products and are especially effective for localized medical applications Deciding what is best for any specific need can be challenging ERBA products have labels containing crucial information about them These labels tell you which cannabinoids are present it can also feel too much for those new to this information An easy search for “Erba weed dispensary” reveals its reputation for exemplary customer care From its vibe to its high standards and expertise Reviews online suggest a large base of loyal customers All dispensaries must test their cannabis. As the Department of Cannabis Control details products must go to independent testing labs and it labels them with accurate cannabinoid and terpenoid profiles Because of its mycelium-like network across Los Angeles ERBA delivers faster than you could get it yourself perhaps a little longer for those in outlying areas This is especially true of the very best kind since ERBA partners with licensed suppliers promoting new products regularly its clients have access to exclusive deals and other opportunities to save money Search “Erba weed dispensary” online for your nearest store and the rest is done for you This means anytime access to the city’s best Contact us today at any of our locations or on our website: www.erbala.com laweeklyLAWeekly Instagram: Featuring the culture of LA since 1978 ✌️ photo credit: Cleveland Jennings / @eatthecanvasllc Virginia Otazo And Erba has a lot in common with these extravagant spots: a giant glass chandelier and enough velvet to make you feel like a shiny ring in a jewelry box But what distinguishes it from these opulent places with little substance is Erba’s deliberate use of local ingredients and care put into each dish Dishes like the eggplant appetizer use vegetables harvested straight from the restaurant’s farm in Homestead. Pastas also feature Key West pink shrimp, Everglades tomatoes, and Bahamian conch. Erba is an Italian restaurant with Caribbean influences and Miami flavor—a taste only our small part of the world could give this food.  HalibutA generous portion of fish swims in a little pool of savory chicken jus and is topped with bits of crunchy mushrooms that balance out the slightly sweet meat. We love halibut, but this is one of our favorites in the city. photo credit: Cleveland Jennings / @eatthecanvasllc and lasagna we refuse to share with anyone—no matter how much we like you Virginia is a Miamian with a creative writing degree She managed restaurants for 11 years before joining The Infatuation Miami in 2022 Introducing the “Rosebud” pilgrimage through Lecco A 90 km circular route starting and ending in Cassago Brianza passing through 20 towns in the provinces of Monza The route was proposed by the Way of St Augustine Association and represents a shorter version of the Way of St CASSAGO BRIANZA – In preparation for the Jubilee 2025 the “Rosebud” is launched as a brief but meaningful pilgrimage experience traveling through the scenic landscapes of Brianza and the Lariano Triangle this circular 90 km trail has been split into five stages/days of walking starting and ending in Cassago Brianza (Rus Cassiciacum) This route offers a reduced version of the Way of St making the pilgrimage accessible to those seeking a significant experience during the Jubilee Year within a more limited timeframe The “Rosebud” takes pilgrims through 20 towns in the provinces of Monza Notable stops include the Basilica of San Pietro al Monte in Civate regarded as one of the most important faith destinations in Northern Italy Designed as a “slow and sustainable” experience the trail accommodates pilgrims of all levels by providing lodging facilities the “Rosebud” joins other short pilgrimage routes in Northern Italy such as the Way of Oropa and the Path of the Gods thus enhancing Lombardy’s offer of spiritual and naturalistic journeys Symbolic themes of this pilgrimage include Romanesque art and the “Villas of Delight” of Upper Brianza along with the strong Marian devotion that permeates the route Votive wall shrines and chapels along the way provide moments for reflection and prayer with the opportunity to stamp the Pilgrim’s Credential at five sanctuaries dedicated to the Virgin Mary There is also a modern twist whereby in Erba pilgrims can visit the Radio Maria headquarters thus enhancing the experience of those motivated by Marian devotion The “Rosebud” is more than a pilgrimage; it is a journey through the history offering an unmissable opportunity to celebrate the Jubilee in an eco-conscious and meaningful way The itinerary of the 90 km circular “Rosebud” pilgrimage route starting and ending in Cassago Brianza-Rus Cassiciacum and logistical aspects for pilgrims are provided on the website www.camminodiagostino.it pilgrims can enjoy this new walking experience in the green heart of Lombardy Faith sites where the Pilgrim’s Credential can be stamped: THE TWO STOPS AT RADIO MARIA HEADQUARTERS ARE: “I introduced myself here as the Queen of Peace to tell everyone that peace is necessary for the salvation of the world Pilgrims may take a moment in the reception area to view brochures about Radio Maria’s worldwide mission We will stamp the Credential for any pilgrim requesting it Fonte: Lorenzo Colombo • 29~12~24 (Erba notizie) This is a vibrant city with an immense array of people any weed dispensary in Los Angeles has a duty of care to its community To those most affected by cannabis prohibition such as targeted minorities and those with victimless pot convictions Weed brings people together. It shares goals, dreams, passions. It sits at the heart of community and has since the beginning of man. Evidence suggests it widely used for various medical, mental, and emotional applications centuries ago already. People were sharing bud around the very first fires. In a primitive age. ERBA brings this togetherness into modern life ERBA Markets offers more than your average dispensary It focuses on improving the cannabis experience The mission is very simple: Pair the best customer service with the very best cannabis products Cannabis enthusiasts across Los Angeles have easy access to ERBA weed dispensaries Because delivery is free and available throughout the city it caters to even more people than brick and mortar stores do alone with security measures in place for added protection ERBA Culver City Weed Dispensary ERBA Markets Venice Weed Dispensary ERBA Markets Weed Dispensary West Los Angeles ERBA puts quality first. A healthy community needs healthy people. If using weed medicinally, it must work, or it will not help. Recreational users want to buzz. Properly. The Department of Cannabis Control explains how the law requires specific quality controls including rigorous testing of cannabis products ERBA makes these results readily available for consumers Because the company makes customers its focus You can learn much from the budtenders available All undergo stringent training to ensure your access to the latest information especially for those using cannabis for lifestyle it might just be the difference between a product working or not Because of its collaboration with the industry’s best suppliers A large menu of the finest quality in all of Los Angeles There are always new products on the shelves Buds remain a favorite among most cannabis users ERBA dispensaries offer an extensive range of the most exciting strains Cannabis concentrates are major bestsellers These extracts are insanely strong and come in many different forms They are especially loved by the non-smoking community and are famously potent Cannabutter is available for those who enjoy baking their own edibles at home and other topicals with medical applications ERBA Markets involves itself in a variety of social equity programs those most affected by cannabis prohibition and others vulnerable in local communities Every ERBA dispensary is an asset to the area Because there are three stores in strategic locations people have access to the best weed there is anywhere in Los Angeles Everybody is talking of exceptional quality Reviews are many and unquestionably positive there really is no other dispensary compared These are the go-to weed dispensaries in Los Angeles Each of its three stores offers a luxury cannabis experience you do not find anywhere else You can find all your cannabis needs met at any ERBA store Website: www.ErbaLA.com Labore doloremque voluptatum blanditiis eligendi placeat min.. Provident et sed voluptate modi quaerat aut repudiandae Iust.. The two had been sentenced to life imprisonment for complicity in the crimes of murder attempted destruction of a corpse and other There will be no review of the trial for the Erba massacre has rejected the appeals filed by the convicted against the ruling of the Court of Appeal of Brescia dated 10 July 2024 which had declared inadmissible the requests for review relating to the sentence pronounced against them by the Assize Court of Como with which a life sentence had been imposed on them for complicity in the crimes of murder Read also other news on Nova News Click here and receive updates on WhatsApp Follow us on the social channels of Nova News on Twitter, LinkedIn, Instagram, Telegram ERBA Markets in Venice was the first retailer in the legal market to incorporate an “in-store” brand experience in their showroom offering companies a direct way to engage with fans.  Devon “Samba” Wheeler is the man behind the vision Raised in the legacy movement by his father Samba was deeply influenced by his father’s beatnik roots a key figure in the 1960s counterculture movement and the founder of LeMar (Legalize Marijuana) the earliest marijuana legalization advocacy organization that Howard joined early on Samba’s father also became the first Westerner to help introduce the Hare Krishna movement to America Samba carries the torch with the same directive for Cannabis culture by fostering quality and integrity Venice Beach is where Jack Herer did most of his legacy work in the early 90s so it was meaningful to plant seeds in the same soil Fun fact: this city is the number one tourist attraction in the state of California over Disneyland with over 10 million visitors annually if you pop across the street to the Harley Davidson dealership you’ll find an ERBA tablet (remote ordering kiosk) you can also have your meds delivered and sitting on your pillion seat by the time the paperwork is signed The staff at ERBA like to think that Jim Morrison would approve of this progressive boutique experience he blesses every happy customer who lights up at the famed Sunday drum circle on the beach.  they see the benefit of building a healthy relationship with the neighbors to create a cohesive That means understanding that there’s a lot to be gained by being friends with surrounding commerce along with supporting local fire and law enforcement through community engagement during the holidays ERBA serves over 3,000 meals for families in need of support and assistance provided by the local neighborhood council The ERBA crew even recently hosted a dog adoption at their sister shop The Woods in WeHo and found forever homes for four canines who just needed a family to love Claybourne Blue Dream –SofiaNo Till Kings –DharaBlem Unruly Original Glue –AlexBlack Caviar Black Squid Ink –Jon The Woods Runtz –SofiaClaybourne Flyers –CamilaHeavy Hitters Diamond Cereal Milk –Jon Cold Fire G.O.A.T Cheese –SofiaFlavorade Cosmopolitan –DharaNasha Papaya Bomb –AlexVuze Alien OG –Camila Mountain Man Melts Tropicanna Cookies –SofiaTall Tree Society Hash Burger –Alex710 Labs Starburst 36 #1 –CamilaPapa Selects Strawberry Gem Jam –Jon Plus Island Maui Haze –DharaAuntie Aloha Lillikoi Citrus Buzz –CamilaPax Gummies Summer Mango –Jon LAErba West Los Angeles on Pico Blvd.The Woods on Santa Monica Blvd.  Photos by @rickerdj The first time Ricker smoked weed was at a Santana concert at the age of 12 He then followed in his footsteps as an award-winning radio personality who became notorious for offering a stage for bong toking listeners in 9 different markets over 20 years the Cannabis industry came calling and the rest is history This article was originally published in the June 2024 issue of California Leaf View our archive on issuu Sign up for the Leaf Newsletter for the latest in Cannabis product reviews District Cannabis has a huge stock of the freshest products Even the mayor asked for a field trip to the store back in 2015 just after opening the doors By entering this website, you are agreeing that you are 21 years of age or above, and agreeing to the terms and conditions and privacy policy An Italian restaurant with a Miami twist and 1920s supper club are among the entries for the prestigious Restaurant & Bar Design Awards but sometimes we eat with our eyes just as much as our tastebuds That’s where the city’s scenic spots whose appearances are just as exciting as what’s on the plate It comes as no surprise to see two of the city’s restaurants make it in the Restaurant & Bar Design Awards for most beautiful restaurants which seeks the best of food and beverage spaces worldwide have revealed the shortlist for this year and it features appearances from Coral Gables’ Erba and Brickell newcomer Delilah Erba makes a stylish first impression with its vibrant hues of pink and red opulent glass chandelier and bright foyer welcoming all diners this upscale Italian restaurant is brought by the team behind Ghee Indian Kitchen and formerly such as mafaldine pasta with Bahamian conch instead of clams and tiramisu with a hint of tres leches it’s easy to see how it can land on a list like this As the city’s modern day supper club it’s a stunning mix of old and new with a roaring ’20s theme It’s also got a color palette of light pink as well as lavish chandeliers and plush interiors Just don’t get too carried away trying to capture it’s appearance — there’s a strict “no photos” policy which would explain why you might see some famous faces dining alongside you there’s favorites like the popular chicken tenders and Kendall’s slutty brownie (named after Kendall Jenner) as well as Miami-inspired flavors like stone crab salad “Cubano Fritters” and suckling pig the Restaurant & Bar Design Awards recognizes and celebrates the world’s most creative spaces and the people behind them The shortlist was put together by a team of 38 judges working across design Look out for your first newsletter in your inbox soon We help you navigate a myriad of possibilities Sign up for our newsletter for the best of the city By entering your email address you agree to our Terms of Use and Privacy Policy and consent to receive emails from Time Out about news Sign up for our email to enjoy Miami without spending a thing (as well as some options when you’re feeling flush) Our newsletter hand-delivers the best bits to your inbox Sign up to unlock our digital magazines and also receive the latest news By entering your email address you agree to our Terms of Use and Privacy Policy and consent to receive emails from Time Out about news, events, offers and partner promotions. Miami We've scanned menus from over 300 participating restaurants to present you with the most enticing deals During Miami’s annual summer restaurant months (August 1 through September 30), we look forward to two things: an absence of tourists and an abundance of discounted meals from some of our favorite spots around town—plus an excuse to check out all the places we’ve been meaning to try This year, with more than 300 participating restaurants (and counting) to choose from, you might only be able to dine at a small fraction of them before tapping out. But we’ve combed through all the latest offerings and, considering the impressive showing of Michelin-starred spots and James Beard-awarded names you’d be wise to earmark some favorites and start booking pronto Wondering where to book your Miami Spice reservations before they sell out Peruse our picks for the most exciting Miami Spice 2024 menus below RECOMMENDED: Miami Spice 2024 Guide Thanks for subscribing! Look out for your first newsletter in your inbox soon! Photograph: Michael PisarriWhat? The original Aba hails from Chicago’s trendy Fulton Market neighborhood where crowds flock to the dreamy rooftop terrace to indulge in a variety of herbaceous cocktails sustainable wines and small plates like short rib hummus whipped feta and black garlic shrimp scampi Find a similar menu at the Miami location inside the ritzy Bal Harbour Shops. During Miami Spice you can choose from brunch and lunch ($35) and dinner ($60) we're opting for items like smoky garlic hummus, the Greek Village salad or short rib shakshuka your first course includes one selection each of hot and cold plates followed by entrees like kebabs and shawarma prime skirt steak frites (+$10) you can choose from three different cocktails (including a zero-proof option) as your dessert we're going for the chocolate orange cremeux with pistachio lunch Monday through Friday and dinner daily 4 out of 5 starsRecommendedPhotograph: Courtesy 27 Restaurant & Bar at Freehand Miami/Justin NamonWhat The acclaimed restaurant at The Freehand Miami presents a $60 dinner menu for Miami Spice 2024 Appetizer highlights include an aji amarillo-soaked Daily Catch Ceviche and the Griot & Pikliz a longtime fixture made with Haitian pork shoulder mornay) and the Smoked Baby Back Ribs (house-cut french fries made with roasted homemade fluff and hazelnut brown butter cookie 4 out of 5 starsRecommendedPhotograph: Michael PisarriWhat This comforting neighborhood staple in MiMo is offering deals for lunch and brunch ($35) and dinner ($45) throughout Miami Spice and it's a pretty amazing deal no matter which route you take: Pick any app entree and dessert from their regular menus. This is an ideal time to check out the restaurant's new expanded space (across the street from the original location) Lunch Monday through Friday; brunch Saturday and Sunday 4 out of 5 starsRecommendedPhotograph: David EscalanteWhat making the trip to chef Thomas Keller's Bouchon Bistro is probably reserved for special occasions or fancy business meals when you can indulge in excellent house classics like escargots steak frites and profiteroles (a perfect dinner Photograph: Courtesy Unsplash/Kelsey KnightWhat Bunbury is as laid-back as it comes for a tapas and wine bar in Miami featuring ample indoor and outdoor seating and plenty of spots to hang out and sip a glass of your favorite red $45 dinner) include items like spinach buñuelos and grilled flap prime steak served with truffle-mashed potatoes an Argentinian homemade flan with dulce de leche and whipped cream that's available with all three menus lunch Tuesday through Friday and dinner Tuesday through Saturday 5 out of 5 starsRecommendedPhotograph: Courtesy COTE Miami/Gary HeWhat With one Michelin star under its belt and a lengthy waitlist for dinner reservations Cote graciously offers its elevated Korean barbecue in the form of a $35 Miami Spice lunch menu Start with something you might not normally order we’re beelining to the Limited Edition Fried Chicken which is brined overnight and includes both white and dark meat with pickled daikon (Though if you’re feeling extra indulgent opt for the Butcher’s Lunch beef assortment for $25 more.) it’s their famed vanilla soft serve with soy sauce caramel—because why mess with perfection honed Delilah in Los Angeles before cloning it in Vegas and the menu in Miami is similar to its sister restaurants partake in a $60 dinner menu featuring many of the classic dishes Macaroni Gratinée (Mimolette cheese fondue black truffle bechamel; add $20) and The Burger (potato bun you can order their famed Kendall's Slutty Brownie for dessert (or opt for Key Lime pie or sorbet) 4 out of 5 starsRecommendedPhotograph: Courtesy DoyaWhat This Michelin Bib Gourmand recipient has already been recognized for its exceptional value take advantage of even greater savings at the lively Wynwood Mediterranean outpost with its $35 lunch menu Score favorites like Muhammara (roasted red peppers choose from the Fig & Walnuts or homemade pistachio baklava Chef Giorgio Rapicavoli's famed Coral Gables hotspot Eating House returns for another Miami Spice at its new home in Giralda Plaza Eating House’s Spice menu features signature specialties like the Kung Pao Cauliflower (herb salad peanuts) and the Pasta Carbonara (black truffle partake in a curated wine pairing with your meal 5 out of 5 starsRecommendedPhotograph: Todd Coleman, courtesy of WoodhouseWhat? It feels special, indulding in a meal this good While few of us are as fashionable as the people strolling the Design District we can at least eat like them at Elastika chef Joe Anthony offers lunch ($35) and dinner ($60) with dishes including tomato gazpacho (pickled tomatillo roasted ora king salmon (forbidden black rice citrus-pine nut vinaigrette) and herb-roasted Green Circle chicken (baby gem lettuce choose from the tropical sundae with mango-passion fruit ice cream or a seasonal selection of cookies and ice cream 5 out of 5 starsRecommendedPhotograph: Courtesy Erba Miami/Evan SungWhat Chef Niven Patel's inventive take on rustic homestyle Italian food gets the Spice treatment with a $60 dinner menu that includes apps like hamachi crudo and pork fennel sausage and entrees like sweet corn ravioli and local mahi mahi choose from the olive oil cake with black plum nutmeg and mascarpone gelato or tiramisu with espresso zabaione 3 out of 5 starsRecommendedPhotography: Courtesy Eva & The Oyster BarWhat If you haven't gotten around to trying chef-restaurateur Michael Beltran's CocoWalk spot a weekend brunch or lunch during Miami Spice makes for a fine moment to pop in For just $30, choose from starters including avocado toast we like the sound of the "Mushrooms" made with a fried egg though the Turkish fried eggs and breakfast sandwich with a fried egg and mortadella also sound delish Brunch and lunch Friday through Sunday; dinner daily 5 out of 5 starsRecommendedPhotograph: Courtesy Fiola MiamiWhat It’s worth a trip to the southern edge of Coral Gables for this upscale the brunch and lunch menus feature lighter fare like pear gazpacho and cobia ceviche for apps; a pan-roasted branzino and lumachine cacio e pepe for mains; and basque cheesecake and budino di cioccolato for dessert indulge with appetizers like the ora king salmon crudo and basil caesar salad with ricotta salata we’re opting for heartier options like the braised Wagyu beef cheeks or the wood oven-roasted Duroc pork chop choose from the chocolate pudding or the raspberry panna cotta 4 out of 5 starsRecommendedPhotograph: Joe’s Stone Crab/Gustavo Lopez. All Rights Reserved.What Available for lunch ($35) and dinner ($45 or $60) South Beach’s famed Joe’s gifts its loyal fans what they crave: discounted stone crabs The more limited lunch menu features items like stone crab bisque a small chopped salad and entrees like Joe’s burger with a choice of sides with additions like cod and ahi tuna entrees The Taste of Joe’s Select entree includes Joe’s fried quarter chicken and three select stone crab claws Lunch Friday through Sunday and dinner Wednesday through Sunday 4 out of 5 starsRecommendedPhotograph: Courtesy Kaori/Sofia BarrosoWhat eclectic Asian spot in Brickell opens its doors for Miami Spice with a $60 dinner menu spicy udon noodles and robata grilled local fish Dessert options are an ube flan with white chocolate ganache or the caramel namelaka made with guanaja sablée Kissaki is a New York City export offering fun lounge-like space at the southern tip of South Beach As part of its first-ever $45 Spice dinner menu you can score Kissaki's signature nigiri flight as an app option (The six-piece flight typically costs $45 on the regular menu select from black cod with miso and bok choy or wagyu fried rice with a poached jidori egg including a bourbon peach cobbler with Japanese vanilla ice cream If you want to find out what all the fuss is about (or remind yourself Miami Spice is a great time to try out dishes like East Coast oysters with martini brine Chilean sea bass with salsa verde and coal-roasted onions or the prime ribeye with a choice of peppercorn or truffle sauce The $60 dinner menu includes a choice of three desserts though we think the yuzu pie with passionfruit coolie and raspberry sounds like a refreshing and fun twist on a classic RecommendedPhotograph: Courtesy Krüs KitchenWhat? Krüs Kitchen is an airy light-filled loft in Coconut Grove serving natural wines and local seasonal dishes with an emphasis on sustainability Both brunch ($35) and dinner ($60) are being offered for Spice this year and we love that they've kept things simple with just two options for each course—meaning you and your dining partner can order one of everything considering it all sounds delicious, including housemade porcini sourdough smoked coconut rice with saffron custard and grilled colossal crab and strawberries with smoked sheep's milk ice cream for dessert 4 out of 5 starsRecommendedPhotograph: Courtesy Le Jardinier/Michael PisarriWhat Chef Alain Verzeroli's menu utilizes the highest quality vegetables seasonal ingredients and fresh herbs in an ultra-modern space choose from melon gazpacho or burrata heirloom tomato salad for your app squid ink linguine or roasted chicken with cilantro yogurt marinade and pearled cous cous salad Dessert is a mango passionfruit layered cake The dinner menu ($60) ups the ante with more substantial dishes like suckling pig porchetta and pappardelle in a zucchini pesto and pacifico striped bass with white bean puree Dinner ends with a chocolate salted caramel tart Lunch Tuesday through Friday and dinner Tuesday through Thursday 5 out of 5 starsRecommendedPhotograph: Courtesy LPM Restaurant & Bar, MiamiWhat A favorite of industry pros and discerning foodies this French-Mediterranean staple in Brickell keeps it simple and elegant this Miami Spice with a $60 dinner menu featuring standout dishes like calamars frits with paprika and green chilli and sweet corn salad with pomegranate and herbs for apps go for the salt-baked striped sea bass with artichokes and tomatoes or the homemade rigatoni with cream and mushrooms Top your fancy French meal off with vanilla cheesecake with berry compote French toast with spiced ice cream or a selection of sorbets Photography: Courtesy Miss Crispy RiceWhat? This intimate sushi counter hidden inside the Oasis complex in Wynwood already serves some of the best value omakase in Miami. For Spice, find even better deals, including a very well-rounded, 10-piece lunch omakase experience comprised of dumplings, crudo, three chef's selection crispy rice pieces, nigiri, a hand roll, soup and a dessert for just $35. The $60 dinner omakase adds three more courses, plus donburi and more premium selections. What? This highly rated NYC import serves up rich and comforting Chinese food in the heart of the Grove. During Miami Spice, enjoy an abbreviated dinner menu ($60) of its highly craveable classics, including the spicy crispy beef, shrimp and snow pea leaf dumplings, wide rice noodles with barbecued duck and grilled filet mignon and broccoli, among others. Choose from three desserts: Key Lime pie, ice cream cookie sandwich or sorbet. This stylish spot serves richly flavored contemporary Indian cuisine in a jewel-toned space tucked away from the chaos off Wynwood’s Northwest 2nd Avenue Both lunch ($30) and dinner ($60) are being offered throughout Spice but we think lunch gives more bang for your buck We're choosing the veggie samosas as our starter followed by the butter chicken as our main and kulfi for dessert consider the gulab jamu as your sweet finisher: not overly sweet milk starch balls marinated in delicate rose water.) 5 out of 5 starsRecommendedPhotograph: Josh VillatoroWhat One of Miami’s top omakase spots offers a mini tasting experience via its $60 Miami Spice dinner menu Stop by the 14-seat counter to enjoy an abbreviated nine-course menu that includes four inventive “appetizer” bites (like the Shima Aji made with a fresno yuzu fermentation) followed by four “entree” pieces like ora king salmon bluefin otoro and akami with everything bagel spice and dehydrated red miso Dessert is a dulce de leche and coconut sponge cake with strawberry sake ice cream 4 out of 5 starsRecommendedPhotograph: Courtesy Stiltsville Fish Bar/Grove Bay HospitalityWhat While most folks will never get out to one of those fabled wood-stilt houses off Biscayne Bay they can savor a fresh catch straight from those waters at Stiltsville Inspired by chef and co-owner Jeff McInnis’s childhood spent fishing in the panhandle and Florida’s abundant marine life the Sunset Harbour restaurant specializes in locally sourced seafood with a modern twist find lunch ($35) and dinner ($60) menus that highlight what the team does best: crab cake grilled mango salad and raw bar selections to start; followed by mains like shrimp and grits and fishtail sandwich during lunch and citrus marinated shrimp and grilled octopus at dinner we're ordering our favorite Stiltsville Key Lime Pie local key lime curd and vanilla whip (though you can order a similar version with toasted coconut during lunch) When? Lunch Monday through Friday and dinner Sunday through Thursday 4 out of 5 starsRecommendedPhotograph: Courtesy The Gibson RoomWhat This elevated Coral Way tavern from chef Michael Beltran is serving up irresistible Miami Spice offerings for its $45 dinner menu chicken schnitzel and scallops in a romesco sauce choose from the sticky toffee pudding with date sponge cake vanilla ice cream and toffee caramel or the lemon tart with blueberry and meringue Offering both lunch ($35) and dinner ($60) this Basque spot in Brickell aims to wow with dishes like pata negra ham and bechamel croquettes, black ink seafood rice, Dover sole with fried capers and citric butter and the manchego cheese fondant served with vanilla ice cream for dessert twitterAbout us Contact us Time Out magazine After a brief stint as a well-received pop-up in 2019, Erba is back — with a new permanent location in Coral Gables from chef Niven Patel and Mohamed Alkassar showcases classic Italian dishes with Florida twists Italian for “herb,” features Patel’s melding of Italian and Miami flavors reflecting the city's diverse cultural influences Menu standouts include Roman hearts of palm mafaldine with Bahamian conch instead of traditional clams and a reimagined tiramisu infused with tres leches But we’re incorporating elements like hearts of palm which isn’t typical to Italian menus,” said Patel “It’s about blending local flavors with Italian techniques.” Much of the inspiration behind Erba’s menu stems from Rancho Patel The farm emphasizes sustainable agricultural practices The restaurant also offers an Italian-focused wine list with over 120 bottles, designed in collaboration with Kirsta Grauberger, Alpareno Restaurant Group’s Beverage Director. Additionally, patrons can sip on farm-to-glass cocktails crafted in partnership with bartender Scott Beattie, who has created cocktail menus for the likes of the three-Michelin-starred the Restaurant at Meadowood in Napa Valley. The restaurant also features one of the best happy hour deals in town. Every day from 5:30 p.m. to 7 p.m., diners can score discount drinks and dine on a $45, six-course pasta-tasting menu. For those who want a more luxe meal, the restaurant also offers an eight-course Chef’s Table for two to six guests with two seatings a night. These are ticketed meals ($195 per person, booked on OpenTable) with two tiers of beverage pairings available. Erba can seat up to 150 guests, spanning its dining area, bar, chef’s table, and private section. Saladino Design Studio crafted the decor, blending Old World pieces with modern elements centered on ‘love’ and ‘connection’. A bright foyer welcomes guests before walking into a space with vivid pink and red walls, Cupid-centric wallpaper with a playful touch of bold colors, and a dog named Dante. “From our whimsical wallpaper to the ambient music—think Marvin Gaye—it’s all curated to exude warmth and passion with a vibrant touch reminiscent of the city of Miami,” said Alkassar. Erba is the latest restaurant in Alpareno’s collection, joining the likes of Ghee Indian Kitchen in Kendall and neighboring Coral Gables’ restaurants Orno and Mamey. As for the group, they are thrilled to continue their expansion in the neighborhood. “We’ve been overwhelmed by the warmth and support from the community. Their genuine appreciation for our offerings has been heartening, making us feel truly at home,” said Alkassar. Erba opens to the public on Thursday, October 5 at 227 South Dixie Highway. The restaurant will be open Sunday to Thursday, 5:30 p.m. to 10 p.m., and Friday to Saturday, 5:30 p.m. to 11 p.m. Oops. Something went wrong. Please enter a valid email and try again. are featured on the list of the most beautiful restaurants in the world according to the Restaurant & Bar Design Awards Two locations in Miami have been included in the prestigious Restaurant & Bar Design Awards list recognizing them as some of the most beautiful in the world appear on this year's finalists list of the global contest that highlights the best gastronomic and beverage spaces worldwide which recognizes and celebrates the most creative spaces in the world and the people who design them compiled its list of finalists with selections made by a team of 38 judges during a ceremony that will take place at The Hoxton in Barcelona Secret Miami described the restaurant Erba as a place that makes an elegant first impression with its vibrant pink and red hues and its bright lobby that welcomes all diners He considered that this luxury Italian restaurant is the work of the team responsible for Ghee Indian Kitchen and he noted that his menu merges Italian flavors with those of Miami such as mafaldine pasta with Bahamian conch instead of clams the mentioned website highlighted it as a "modern city dinner club it is an impressive blend of the old and the new It also highlighted its palette of light pink as well as sumptuous chandeliers and luxurious interiors He also pointed out that the establishment has a strict policy that prohibits taking photos which is why it is not uncommon for the place to be visited by celebrities was recognized as one of the ten most beautiful in the United States in association with the reservation platform OpenTable placed it in the ninth position on the list of the 50 most beautiful restaurants in that nation and environmental features that the establishment possesses three restaurants in Miami joined the Michelin Guide 2024 which already has several establishments from Florida nine restaurants in Florida were awarded Michelin stars and three of them are located in Miami: EntreNos Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application a son of the late Carlo Antonio Dell’Erba and Lena Moscatiello He worked as a chef for many years throughout Worcester County with his last job at The Kittansett Country Club in Marion He then owned and operated The Sunshine Deli in Worcester near Clark University where he befriended many neighborhood residents and students Matteo was a member of the Worcester Senior Center where he visited for lunch daily He enjoyed going to his daughter’s house on Cape Cod where he spent time at the beach and visiting with friends and family He loved New England sports and was especially happy to witness the Red Sox win the World Series in 2004 Ramona (Mocker) Dell’Erba passed away on June 1 NH and Marty Dell’Erba and his wife Catherine of Shrewsbury with whom he lived; a daughter Jacqueline Hoegen and her husband Kevin of Uxbridge; a daughter-in-law Rachel Stockwell and her husband Quentin of S Christopher Dell’Erba and his wife Francesca of Shrewsbury William Dell’Erba and his wife Julia of Nantucket and Jesse Guay of Grafton NH; three great grandchildren and one due in September Aidan and Elliot Stockwell and George Dell’Erba; and many nieces and nephews he is predeceased by three brothers; Martin and Louis Ragucci and Thomas Dell’Erba and five sisters; Angeline Antonucci Philomena Nelson and Theresa Dell’Erba; a son-in-law His funeral service will be held on Monday 2021 at 11:00 am in the MERCADANTE FUNERAL HOME & CHAPEL  A period of calling hours will be held on Sunday September 12th from 5-7 pm in the funeral home kindly consider making donations in Matteo’s memory to: Elder Affairs at the Worcester Senior Center Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors compared ziftomenib with other Menin inhibitors and discussed data from the phase 1/2 trial evaluating the menin-KMT2A inhibitor in patients with AML ziftomenib (KO-539) monotherapy led to antileukemic activity and a manageable toxicity profile among heavily pretreated patients with relapsed/refractory acute myeloid leukemia (AML) according to findings from a phase 1/2 trial (NCT04067336) Ziftomenib is an oral investigational drug designed as a highly potent and selective inhibitor of the Menin/KMT2A interaction this leads to the downregulation of HOXA9 and MEIS1 ziftomenib 600 mg was administered to patients with NPM1-mutated disease who were enrolled in phase 1a and 1b of the trial (n = 20) Treatment with the menin-KMT2A inhibitor produced a complete remission (CR) rate of 30.0% the CR/CR with partial hematologic recovery (CRh) rate was 30.0% Ziftomenib at 600 mg also generated a minimal residual disease (MRD) negativity rate of 42.9% and an overall response rate (ORR) of 40.0% Patients with KMT2A-rearranged disease enrolled in the phase 1a and 1b portions of the trial (n = 18) who were given the agent at 600 mg had a CR/CRh rate of 5.6% the MRD-negativity rate with the ziftomenib was 100.0% the FDA has selected 600 mg as the recommended phase 2 dose for patients with NPM1-mutated AML “What we're excited about is that we believe there is single agent activity and NPM1-mutated disease that may be useful to some of our older patients who get HMA then relapse and don't have any other options A single agent Menin inhibitor with a 30% to 40% response rate with a tolerable toxicity profile would be an advantage,” Harry Erba Targeted Oncology: Can you discuss the mechanism of action of ziftomenib Erba: Ziftomenib is an oral investigational agent that inhibits the interaction between Menin and the protein KMT2A This is an important interaction because that interaction leads to upregulation of HOXA9 and MEIS1 and in so doing it causes proliferative signal blocking differentiation in the cells decreases the expression of HOXA9 and MEIS1 What can you tell us about the use of Menin inhibition in AML we would expect a Menin inhibitor to be effective in any of the AML where the pathogenesis of leukemia is related to signaling through that Menin KMT2A fusion or interaction where this is a critically important interaction that underlies the leukemogenic properties of the mutation One is the nucleophosmin or NPM1 mutations and the second are KMT2A rearrangements or fusion proteins Those 2 will lead to activation of the Menin KMT2A complex and upregulation of HOXA9 and MEIS1 An inhibitor there would be important in breaking that pathogenic signal There are others that may be important besides NPM1 and KMT2A Other fusions are known to work through the Menin and proteins such as NUP98 it's speculated that in AMLs with upregulation or overexpression of HOXA9 and MEIS1 presumably through this Menin and KMT2A interaction a Menin inhibitor may also be important there How does ziftomenib compare with other Menin inhibitors There are a few Menin inhibitors already in clinical development None are FDA approved or commercially available at this point The first is revumenib [previously known as SNDX-5613] and then there are a number of other investigational agents What's different about ziftomenib from revumenib is [what] I could see in terms of toxicity profile We don't see the same QTC prolongation signal that was seen with revumenib we saw activity of ziftomenib in the KMT2A-rearranged patients there was an early increase in the blast count and an atypical differentiation syndrome We did not see any objective responses in the KMT2A-rearranged patients unlike what was seen in the revumenib studies Now we believe and we see incredible activity in this on-target effect We believe that we'll still be able to develop ziftomenib in KMT2A-rearranged patients but we still have to look in a little bit more detail at the dose and combination strategies there we saw a 30% complete remission rate in 20 patients treated the recommended phase 2 dose so quite a good dataset and s a single agent a rate of inhibition or rate of complete remission that rivals what we see with IDH inhibitors that have already been approved based on single agent activity Can you discuss the methods and design of the phase 1 study evaluating ziftomenib There was a phase 1a portion and this was for all comers About half the patients had either a KMT2A or an NPM1 mutation but this was looking for the dose to bring forward We treated patients in the phase 1a portion with doses from 50 to 1000 mg a day We saw 2 patients with an NPM1 mutation achieve either a complete remission or morphologic leukemia-free state The patient who achieved a complete remission remains in a complete remission for over 2 years and single agent ziftomenib We also saw a response in a patient who did not have NPM1 or KMT2A rearrangement The patient had a SETD2 RUNX1 mutational profile and there are some who believe that Menin inhibitors may be active in RUNX1-mutated AML what we decided what to do for the phase 1b portion was to take to heart and listen to the guidance that the FDA has recently given out on the development of these targeted inhibitors The FDA initiative is called Project Optimus and what it acknowledges is something that we've all known it may reach its maximal activity based on PK or PD [pharmacokinetic or pharmacodynamic] studies before it actually gets to a maximum tolerated dose There are plenty of examples of the development of drugs in AML that missed that signal and went too far maybe in the development of the drug in phase 1 and we developed the 2 lowest dose levels at which we saw responses That was the phase 1b portion of the study There we enriched the population of NPM1-mutated and KMT2A-rearranged patients to look for on-target activity What are the main findings from this part of the trial so how are we going to determine from this dose optimization and what should be the recommended phase 2 dose We had 20 patients with NPM1-mutated disease that received 600 milligrams daily and then another CRi [complete remission with incomplete hematologic recovery] and then another morphologic leukemia-free state we saw no grade 3 or higher toxicities occurring at more than 10% of the patients but we did see some grade 3 or higher toxicity we saw 4 patients have a differentiation syndrome None of the patients died of differentiation syndrome in the NPM1-mutated group and 75% of the patients who had differentiation achieved a response suggesting that it is the mechanism of action I presented the data for 1 patient showing how her bone marrow did develop into a quick morphologic leukemia-free state and then a couple of cycles later We saw downregulation of the target genes HOXA9 and MEIS1 at the 600 mg dose more so than at the 200 we didn't see any further downregulation we feel secure in our data that 600 mg once daily is the right dose to take ahead in patients with acute myeloid leukemia and the FDA has agreed to that and so the study has been amended now to get us into the expansion phase at 600 mg once daily often without signs of differentiation in the blood and then unusual forms of differentiation syndrome we saw patients develop Gingival Hyperplasia in the first cycle that went away and that was from the disease responding in that cycle A patient developed pleuritis that wasn't explained by anything else and went away with steroids Another patient had a serositis of the knee and then in muscle that came and went with steroids finding no other infectious etiology for it The reason we think this is happening is that we know that KMT2A-rearranged AML often has a monocytic morphology and has a high incidence of extramedullary disease The other thing is that ziftomenib accumulates in tissues and we showed that in the phase 1 portion of the preclinical studies What we believe is happening is that with a single agent we are seeing abrupt rises in the blast count and this differentiation It caused some investigators to take their patients off study We've clearly seen morphologic leukemia-free state and marrow clearance a blast but have not been able to keep patients on long enough to see complete clearance of extramedullary disease and reconstitution blood counts But we feel secure that we will be able to find the right dose and especially the right combination of ziftomenib with chemotherapy to help ameliorate that signal of differentiation syndrome and KMT2A-rearranged patients those are the patients in the expansion that we will be enrolling at the 600 mg dose How do you foresee this agent being used in clinical practice KMT2A-rearranged AML is pretty atypical and unusual we know that they can get into a remission and relapses are the hallmark of this disease unless a patient is able to go through allogeneic stem cell transplant The other place I see the KMT2A-rearranged AMLs are in patients who have received prior topoisomerase II inhibitors a therapy related AML with the KMT2A rearrangement I see 2-3 women who have gone through adjuvant therapy for breast cancer and then ended up developing this disease especially in acute lymphoblastic leukemia Favorable risk is only in relationship to the rest of the populations of AML Although NPM1-mutated disease is considered favorable risk and ELN risk stratification and NCCN risk stratification and it appears to be related to the co mutations half of the patients with an NPM1 mutation will have a FLT3-ITD mutation NPM1 mutation and a DNA methyltransferase 3 alpha mutation the prognosis is poor with a 20% survival as shown by a retrospective analysis of a German database A testimony to that is we were able to find and put on a study of 20 patients with NPM1-mutated disease in the relapsed/refractory setting on the 600 mg recommended phase 2 dose What we're excited about is that we believe there is single agent activity and NPM1-mutated disease that may be useful to some of our older patients who get HMA A single agent Menin inhibitor with a 30% to 40% response rate with a tolerable toxicity profile would be an advantage But clearly where we expect to go is where we expect to go with all these targeted therapies in combinations with chemotherapy with other targeted therapies and maybe even immunotherapy at some point The sponsor of this trial has already written a phase 2 study that has ziftomenib in combination with intensive chemotherapy gilteritinib [Xospata] in the relapsed/refractory setting and then also arms of the study of HMA venetoclax or intensive chemotherapy with ziftomenib in previously untreated patients in the appropriate patient population for each either fit or unfit for intensive chemotherapy We apologize, but this video has failed to load.Try refreshing your browser, ortap here to see other videos from our team.Play VideoArticle contentEarly on Feb officers arrested a man who was seen rummaging through vehicles on East Street North near Lincoln Park Avenue The man had tools “clearly marked with another person’s name,” police said Tools valued at about $2,000 were returned to the owner Other stolen property was also returned to nearby residents officers were called shortly before 10 p.m to Oxford Street – about 250 metres from East Street and Lincoln Park Avenue – after a person reported thefts from vehicles Officers found a man sitting inside a vehicle there An officer tackled the man to the ground a short distance away “It was necessary to subdue the suspect with physical strikes in order to take him into custody,” police said Erba was further charged with resisting arrest Erba appeared in court Wednesday morning by video from the Sarnia Jail He was kept in custody and his cases were adjourned to Friday Erba is now facing seven sets of charges in Sarnia which have all been laid since late January None of the charges have been tested in court tbridge@postmedia.com transmission or republication strictly 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By continuing to use our site, you agree to our Terms of Use and Privacy Policy Infinera’s CEO David Heard and CFO Nancy Erba described a paradoxical first quarter during the company’s Q1 earnings call “bookings were in line with our expectations while design win momentum was unprecedented and the strongest the company has ever seen quarterly revenue of $307 million came in 4% below our outlook range and was down 22% on a year-over-year basis.” Heard attributed this revenue decline to a slower release of orders and a pushout of shipments from the first half of the year to the second half of the year “We believe these market dynamics will continue through the second quarter before business conditions start to normalize in the back half of the year enabling us to get back to year-over-year growth in the second half,” he said Heard said that Infinera is positioned to meet customer needs going forward “We remain laser-focused on our priorities,” he said “which are to grow and take market share in the $11 billion-plus systems market ramp our business in the growing $5 billion market for coherent pluggables and leverage our vertical integration capabilities to break into the high-volume $2 billion intra-data center segment driven from the optical payloads of AI.” Heard reported continued momentum with hyperscalers thanks in part to the company’s GX portfolio He also reported that Infinera continues to win managed fiber optical network deals in India “These land-and-expand opportunities start out small but with the expected growth in these regions we expect them to become a more significant portion of our revenue in the future,” he said Erba delved deeper into the quarter’s financial details outlining some explanations for the revenue decline “Our Q1 revenue decline was primarily attributable to lower volumes in the U.S across both our major service provider and ICP customers due to the slower release of book ship orders and project pushouts and an overall cautious spending posture from our customers,” she said we derived approximately 54% of our Q1 revenue from domestic customers a lower percentage than the trend of the past two quarters.” decreasing 220 basis points year-over-year “Compared to the prior year,” she said “the primary driver of the lower gross margin in the quarter was the higher contribution of line systems to product mix the impact of fixed costs under absorption from lower revenue and volume.” Erba reported that Infinera’s line systems revenue was up approximately 20% year-over-year which she said positions the company for future transponder deployment Operating loss for the first quarter was $25.9 million and Infinera generated $24 million in cash flow from operations and $16 million in free cash flow Erba reported that Infinera anticipates Q1 business dynamics to carry into Q2 and the company gave an outlook of a year-over-year decline of 10% to 15% in Q2 the company expects revenue to be down 1% to 5% compared to 2023 “The near-term operating environment remains very challenging across the industry as our customers continue to work down excess inventory and push out some projects,” she said For related articles, visit the Business Topic Center For more information on high-speed transmission systems and suppliers, visit the Lightwave Buyer’s Guide To stay abreast of fiber network deployments, subscribe to Lightwave’s Service Providers and Datacom/Data Center newsletters. Hayden Beeson is a writer and editor with over seven years of experience in a variety of industries Prior to joining Lightwave and Broadband Technology Report he was the associate editor of Architectural SSL and LEDs Magazine.  By entering your email address you agree to our Terms of Use and Privacy Policy and consent to receive emails from Time Out about news By entering your email address you agree to our Terms of Use and Privacy Policy and consent to receive emails from Time Out about news, events, offers and partner promotions. every meal at Erba begins with a candle of garlicky butter carried to the table with slices of focaccia Our knives just about clanked as we smeared each morsel with the melty butter the fragrant rosemary sprig wick flickering at the candle’s center this meal feels precious (and tastes delicious).  I’m predicting we’ll likely start to see butter candles everywhere so maybe they won’t stick around at Erba forever from chef Niven Patel’s Italian-inspired creations to the restaurant’s luxurious look for the glass doors painted with cherubs riding hounds (there’s no sign out front) the moody vibe comes courtesy of warm lighting richly hued textiles and dark wood paneling layered throughout An opulent glass chandelier hangs at the room's center like a frozen waterfall.  The menu is an homage to the time Patel spent in Florence the acclaimed chef uses vegetables grown at his own farm here and flavors them with a deft hand served at room temperature and adorned with a few leafy herbs.  The wahoo crudo comes served as seared slices fanned out like islands each one populated with little orange segments and Fresno chilis none of it overpowering the delicate flavor of the fish.  the Mishima Reserve Denver Steak is a well-seasoned beef chuck cut that gets a topper tableside of bone marrow and salsa verde The Ora King Salmon arrives with a cracker-crisp skin and a sweet sunchoke puree that's all pretty spot-on The next section of the menu is dedicated to pasta with the kitchen picking six samples for $45 perfectly al dente parcels in a beefy broth with hunks of beef cheek dotted here and there bursting with velvety ricotta stuffing and covered in a creamy sauce dotted with nutmeg and white truffle bits.  That ravioli got us thinking about the prices at Erba which run from reasonable (like $18 for the eggplant and $38 for the ravioli) to exorbitant (like $62 for the steak) Just know that if you’re headed to Erba or watching Alfred Hitchcock films so much that you become a sexist monster (allegedly) but it’s clear that leveraging the language of filmmaking and eerie sounds can’t hurt Ponte Del Diavolo in many ways sound like the way it feels watching classic Italian giallo films: the psychological terror the melodies that feel arresting yet spine-tingling and the sense that something is following you all the time Combine a kind of melodic gothic doom with hints of black metal and 80s darkwave and you’re most of the way there So much of Fire Blades from the Tomb is surprisingly not heavy until all of a sudden a song sounds utterly massive That’s the kind of thing only keen songwriters and lovers of good films understand: the unexpected is always king So how does a band come up with music that feels so visual and haunting From being as free in expression as possible: “What we play and write comes from the heart,” vocalist Erba del Diavolo says “The only thing we want to pursue is the freedom of expression contact with nature and the most creative and living part of man I would say that many of our unspoken secrets are unintentional,” bassist Khrura Abro adds We want to play metal and we are happy and proud to do so but we don’t only listen to metal music On a conscious level I would say we just tried to balance the more aggressive parts with the more atmospheric ones but in general everything was very natural and spontaneous as this band has always been we have a quite raw and instinctive approach to composition.” Fire Blades From the Tomb is out now from Season of Mist. Follow Ponte del Diavolo on Facebook and Instagram for future updates Issue 73 featuring Pinhead Gunpowder is available now This website uses cookies to ensure you get the best experience on our website  Learn more Today marks the release of “EJJA,” the highly anticipated debut collaboration between Maltese singer/songwriter MATT BLXCK and the energetic girl group ERBA’ The two acts first met at the first edition of the Malta Eurovision Exchange Camp Even though they competed with their respective songs “BANANA” and “SIRENA” an instant connection between them led to this exciting project Matt and ERBA’ jokingly refer to themselves as Ħamsa since and the playful name reflects the fun they’ve had working together “This collaboration was bound to happen at some point and I’m happy that it’s finally seeing the light of day.”  Both Matt and ERBA’ expressed their delight in working together “We really enjoyed the experience and hope to get the chance to perform it together soon.” “EJJA” captures the vibrant energy of all five artists and serves as the perfect send-off to the summer season The release is accompanied by a lyric video that emphasizes their camaraderie while highlighting the song’s infectious “EJJA” is available on all major streaming platforms Matt and ERBA’ are hopeful this collaboration sparks many future projects together CFO Nancy Erba dishes on how she strives to lead by example when it comes to women in the workplace Nancy Erba credits her ability to make connections for her successful journey to the top financial seat she advised that other women do more networking Graduating with a degree in math from Smith College Erba came up the financial ranks through a science “before it was known as STEM,” she told CFO Dive in an interview After receiving her master’s in business administration with a concentration in finance and economics from Baylor University “I kind of grew up there in terms of their finance organization and I got to see a lot of different roles and move throughout the organization so I spent time in sales and marketing and running corporate development and then moved through the finance ranks,” she said Erba was introduced to Infinera by a female member of the board who was also a colleague of hers at a company she was previously CFO at and I am here to show people that it can happen with women too,” she said Infinera is a provider of network infrastructure systems automation software and professional services they have over 1,000 clients in over 100 countries and six continents When it comes to bridging the gender gap in industries like that of tech it starts with the culture set at your own organization “We really made a concerted effort to try and reduce the gap between male and female in terms of the number of employees at our company a collaborative and transparent communication style is what allows the company to be successful and it is a big part of how the recruitment process works Erba is responsible for all of the run of the mill CFO duties —  accounting and she also handles a lot of the IT and government affairs “but my experience has been one where the culture at Infinera was really attractive to me,” she said A big part of how Erba and the leadership team at Infinera practice what they preach is building a pipeline of candidates from the start “So we're looking to hire more at intern level and at early in career bringing folks in and recruiting at colleges,” said Erba “Some people think ‘well there just aren’t that many women engineers or women in tech’ and that’s just not true,” she said Infinera also looks to set an example within by implementing mentorship programs “It started as programs for women in the company but we saw such success that we now have expanded to the entire organization,” she said “It's leadership throughout the organization If programs like those that Erba spoke of had been around when she was working her way up the financial ranks I certainly would not have been the only woman in the room I think the companies I was at would have benefited as well with more women representation,” said Erba noting that companies benefit from broader diversity in decision making and in running programs and in growing an organization In terms of how Infinera in particular holds itself accountable Erba believes that “what gets measured is what gets done and so by measuring these types of things like who are the decision makers and is it as diverse as it can be is how we hold ourselves accountable,” she said Get the free daily newsletter read by industry experts State changes to licensing rules are chipping away at a decades-old system that has largely required CPA candidates to complete what effectively amounts to a fifth year of schooling scheduled to assess monetary policy during a March 18-19 meeting will likely zero in on a jump in long-term inflation expectations Subscribe to the CFO Dive free daily newsletter The free newsletter covering the top industry headlines Assistant Professor of Corporate & Financial Law at University of Zurich Marco Dell’Erba joined the Wilson Center as Global Fellow in the Science & Technology Innovation Program to study the financial implications of the cryptoeconomy cryptofinance and the emergence of the metaverse.  Marco Dell'Erba is Assistant Professor of Corporate & Financial Law at the University of Zurich where he is also a member of the Blockchain Center and the Digital Society Initiative He is a Fellow at the Institute for Corporate Governance & Finance at New York University School of Law and a member of the Advisory Board of the Research Network for Sustainable Finance a research initiative involving leading academic institutions He previously held research positions at New York University where he was Global Fellow affiliated with NYU’s Institute for Corporate Governance and Finance and the Center for Financial Institutions; at the University of Paris I Panthéon-Sorbonne (Financial Regulation Laboratory of Excellence); the National University of Singapore; and at the London School of Economics as a Research Assistant in the Department of law during his PhD He practiced law in the departments of Banking & Finance and Litigation & Dispute Resolutions at Clifford Chance LLP (Rome) and as an independent consultant (Paris) Marco Dell’Erba holds a JD summa cum laude from the University of Rome La Sapienza and is a fellow of the Lamaro Pozzani University College of Excellence (Rome) where he was awarded a five-year full merit-based scholarship He obtained his LL.M in Corporation Law at the New York University School of Law where he was Global Hauser Scholar and served as Graduate Editor in the NYU Journal of Law & Business He holds a PhD in private law and financial regulation from the University of Paris I Panthéon-Sorbonne and a PhD in corporate and securities law from the University of Rome Tor Vergata He earned his Professorial Habilitation in Corporate & Financial Law at the University of Zurich Marco Dell’Erba has published in American and European journals and his research was featured on the Columbia Law School Blue Sky Blog and the Machine Lawyering of the Chinese University of Hong-Kong His research interests include Financial Law & Banking Law Bhaiwal brings a record of excellence in the medical devices Ravindra Bhaiwal has joined Erba Transasia as Vice President – Technical Services With over 25 years of experience in customer service In his previous role at Numeric (a Group Company of Legrand) Bhaiwal led the service P&L of over ₹350 crore overseeing a team of approximately 1,200 service professionals across 250+ locations Bhaiwal has seven published books and numerous motivational articles to his name Δdocument.getElementById( "ak_js_1" ).setAttribute( "value"