Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here by Ernesto Lella  We have reached the second year of this memory of Nicholas Ugon a historic Ercolano merchant whose business has exceeded 60 years and is now masterfully run by his daughters Laura and Roberta after he decided to race through the skies in his 500 to look down on us with satisfaction because seeing 77 of "his" 500s pass in front of his shop (yes all the Cinquecento enthusiasts of Campania have known the legendary Ugon even just for a tip) in a continuous parade going and returning so we could then position ourselves in the ZTL of the center could only have been welcome.Even this year because there were two moments of aggregation agreed with mayor Ciro Buonajuto who strongly wanted the event again and gave each participant a touching souvenir parchment Also worthy of mention is the councilor Pius Valletti who contributed to the meticulous organization in addition to "extending the ZTL" when he realized that the cars were exceeding the limit perfectly coordinating all the patrols that accompanied our morning colorful and honking “snake” through the small streets of the city.Appointment at 9 in Pugliano Square (or Resina which gives its name to the homonymous market of used and vintage clothes where you can get great deals for those who love the genre and is known by all the "insiders") But when we arrived at 8,30 there were already about twenty early risers even with the scooter as Giuseppe Raffaele our legendary “Peppe 'o Fotografo” who immortalizes our gatherings with splendid images breakfast offered by the Ugon sisters and at 10,30:XNUMX greeting from the mayor and the authorities with “exchange of gifts” the appointment for next year.The Campania representative is present Domenico Filippella the newly elected trustee of Salerno Bruno Gennatiempo in addition of course to the trustees of Naples Center and Naples South Antonello Martina e Francesco Puzone many members and even non-members who have expressed their desire to join the Club necessary stop at the Autoricambi Ugon shop and settling into the ZTL for the static display of the cars on display for the enjoyment of hundreds of people families with children (the Club's balloons were very welcome) and above all many amazed and pleased tourists who "forced" to pass directly to visit the excavations of Herculaneum brought back photos and selfies of our shiny little boxes as an added value to their visit in this wonderful place where time has stopped offering us a glimpse into the life of our ancestors 2000 years ago and unfortunately also of the sudden death of those who were surprised by the catastrophe.Enthusiastic balance which once again confirms the power of our passion that can involve anyone ordinary people who stop us to tell anecdotes memories that emerge in the memory accompanied by big smiles Official closing on Monday in the office of Col Vanacore (absent from the event due to force majeure) who welcomed us with a dazzling smile that showed all the satisfaction for the great success of the event in his city When we made a dutiful apology for exceeding the number of cars he answered us even more pleased: «But you understood that they also called me telling me “these (us) said that reservations are closed Nico': see what you can do…”» and he greeted us by adding: «Okay next year we'll extend the ZTL again and do it 100 machines»…the sixteenth-century syndrome has struck again Privacy PolicyExtended informationFiat 500 Club Italia Logos – Registered TrademarksCookie PolicyLegal notices Fiat 500 Club Italia, Via Roma, 90 – 17033 Garlenda (SV) – PI 01079820096 | Copyright © 2025 | All rights reserved. | Website created by CT Solution Your membership card plus gadgets will be sent to you through mail, while you may download the 6 issues of the magazine 4PiccoleRuote from the website. 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All rights reserved discusses the treatment of sarcomas in an era of molecular medicine orthopedic oncologist and chief of musculoskeletal oncology at Allegheny Health Network Over 100 histological subtypes of sarcomas have been characterized to date clinicians hope to be able to use targeted treatments for specific mutations and further understand the molecular differences between tumor types 0:10 | We definitely have learned a lot in terms of being able to sequence these tumors and get down to the molecular level I'd say that that's been most helpful in diagnosis thus far There's a number of types of bone sarcomas there's actually sort of hundreds of types of soft tissue sarcomas and that number keeps getting longer and longer as we continue to sort of subdivide some of these out That's where a lot of the molecular work has helped us 0:44 | Whereas once there used to be an entity called malignant fibrous histiocytoma that name doesn't even exist anymore for soft tissue sarcomas because now we know that that thing is actually many different things that we've been able to parse out We've been able to do that with an understanding of the molecular differences between these different tumor types the goal is that that can turn into targeted treatments for each of these we have drugs that target these specific mutations that come about in terms of finding drugs that drastically improve outcomes There are some that we think help with prolonging what we call disease-free survival and things like that but we haven't had any total breakthroughs yet That speaks to the fact that we need more research and more money to do research which is hard because it's a rare disease It kind of gets lumped into the orphan diseases and doesn't get as much notice or funding as other types of cancers Stay up to date on practice-changing data in community practice Maintenance Regorafenib in Advanced Soft-Tissue Sarcoma Delays Progression A phase 2 study showed that giving maintenance regorafenib could delay disease progression in patients with non-adipocytic soft tissue sarcomas Breaking New Ground in Synovial Sarcoma: Choy on the FDA Approval of Afami-cel discussed the FDA approval of afamitresgene autoleucel for the treatment of patients with advanced synovial sarcoma Dara-VRd Leads to Sustained MRD Negativity in Newly Diagnosed Myeloma discussed updated outcomes from the GRIFFIN and PERSEUS clinical trials of quadruplet therapy in multiple myeloma Strategies for Neoadjuvant NSCLC Treatment discusses neoadjuvant therapy for patients with non–small cell lung cancer Reimagining Cancer Care: AHN’s Radiation Oncology Program as chair of its Department of Radiation Oncology AHN Launches Robust Peer Support Program for Cancer Patients The Allegheny Health Network Cancer Institute announced the launch of its comprehensive Community Cancer Patient Ambassador Program 609-716-7777 This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Big news for history buffs and the morbidly curious: An ancient Roman beach is now open to the public for the first time since it was destroyed by the eruption of Mount Vesuvius in 79 AD The beach at the Herculaneum archaeological park, located in the southern Italian region of Campania, opened on Wednesday after a multi-year restoration project after three years of intensive work aimed at the enhancement of the ancient beach of the Herculaneum excavations by draining and filling the area formerly occupied by the sandy shore visitors are given free access over the entire area and an understanding of the dynamics that led to the burial of the city," said Carabinieri Brigadier General Giovanni Capasso Abbiamo riaperto l’antica spiaggia di Herculaneum, all’interno del Parco Archeologico di Ercolano. Il nostro impegno sta ridando splendore e valore a questo luogo. Grazie al direttore Francesco Sirano e al personale per il loro impegno. pic.twitter.com/tEvpl6YBwP Herculaneum — named for the Greek god Hercules — is believed to have been founded by the Oscans in the 7th century BC and dominated by Rome in 90 BC. Its location on Italy's west coast and mild climate made it a popular resort town for Rome's patrician families It was much smaller (both demographically and geographically) than the city of Pompeii Both were destroyed in the eruption of Mount Vesuvius buried by clouds of ash and volcanic debris that preserved them in place for centuries Herculaneum lay buried longer, beneath some 50 meters of ash, until it was discovered by accident in 1709 as a worker drilled a well for a monastery A series of excavations of the site during the 18th and 19th centuries uncovered parts of buildings, ornate works of art, papyrus scrolls and other artifacts But archaeologists found few human remains in Herculaneum unlike the perfectly preserved casts of bodies at Pompeii That led them to believe that most of the city's inhabitants had been able to escape the volcano's wrath in the direction of Naples uncovered the skeletons of more than 300 people in stone boathouses near the beach The human remains hold clues for researchers about how inhabitants of Herculaneum both lived and died One famous skeleton, for example, is referred to as the "Ringed Lady," because of the emerald and ruby rings sparkling on her finger. Another, first discovered in the 1980s near the remains of a boat, is now thought to belong to a senior Roman soldier likely sent on a rescue mission And in their most recent dig in 2021, archaeologists uncovered the remains and personal belongings of a man they are calling "the last fugitive." The black and reddish bones (stained by blood experts say) of a man believed to be between 40 and 45 years old were found just steps away from the shoreline “He was possibly escaping with his treasures," conservator Nunzia Laino told The Guardian at the time The boathouses, with their arched entryways and skeleton replicas Park director Francesco Sirano said in a news release that the conservation work aimed to reduce the risk of flooding restore the original level of the beach and bring back sand to "let everyone walk on the beach again." "If we turn our heads to where the sea once was we become modern explorers of the immense blanket of volcanic flows that covered the city in a few hours," he added "And we cannot help ourselves from sharing almost the sense of total annihilation of our human condition in the face of the evidence of [the] cataclysm of 79 AD." The beach area is one of multiple sites visitors can explore at Herculaneum. Other popular attractions open to the public include well-preserved baths, an underground theater and luxurious residences with elaborate mosaics Become an NPR sponsor READ THE ARTICLE READ ALL THE REVIEW There are no less than 17 Italians among the three hundred volunteer 'angels' who contribute to.. 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READ ALL THE ARTICLE Send help right to the people and causes you care about Your donation is protected by the GoFundMe Giving Guarantee Founder and CEO of Redemption FitnessAfter first jumping into franchising as a franchisee The Ultimate Guide to Selling Franchises: Building Your Brand’s Growth Machine Franchise Real Estate Services | Locate AI — Emerging Leaders in Franchise Support Big Sky Franchise Team: Expert Consulting for Scalable Growth Yum Brands Reports Strong Q1 Results with Big Boost from Taco Bell QSR: McDonald’s Gains Momentum With Chicken Innovation, Value Deals and Franchisee Support The Future of Franchising: Trends and Predictions for 2025 and Beyond Restaurant Business: Crumbl Cools Its Expansion, Refocuses on Profitability Pool Scouts Expands Hope Floats Fundraising Efforts for 2025, Aiming to Surpass $100,000 in Total Donations Why Rochester, New York, Is a Great Market To Open a Filta Environmental Kitchen Solutions Franchise Fresh Coat Cares: Painting a Brighter Future for Communities Nationwide Franchise Broker Turned Owner Opens Kid’s Ninja Gym in Kansas City Reading"Illustrator Derek Ercolano’s..." 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POV Forward Thinking Review of the Year Jenny Brewer Olivia Hingley Ellis Tree Elizabeth Goodspeed Liz Gorny Extra Search his portfolio was filled to the brim with weird and colourful characters set among a 70s sci-fi landscape and psychedelic hues He’s still hitting the mark with the exceptionally strange and surreal figures The artist has transitioned into an experimentation with darker tones and simplifying his technique We caught up with Derek to find out more about this transition to the darker side Tell us about your transition: what have you learnt from this phase of work I have always been a bit uncomfortable with ‘shading’ my work I was never into drawing with a pencil — it was the spontaneity and immediateness of drawing with a pen that felt exciting to me I think the most exciting part of approaching images in this way is the feeling of not quite being sure of how things will turn out in the end over time this approach has given my work a sort of graphic quality that eventually I felt a bit too comfortable with I decided to start exploring tone and value in my work to see if it would be something that would allow me to experiment with things in a new way I would say that doing things in this way over the last year has made me become a bit more mindful of my compositions which I feel has benefitted my work Run us through this “experiment with tone and value” How do you achieve this and how does this tie in with your colour images The first few images I made while experimenting with this technique were actually in colour and they were fantastically bad I decided that if took colour out of the equation I would make myself focus on the bare essentials I intended to add colour to the images after completing them but I found something really refreshing about keeping the images in black and white sort of cosmic feeling that I got from them and I decided I wanted to continue to explore it Although the work doesn’t have the bright colours I usually gravitate towards I feel that the images have a new level of detail that makes them bold in a different way has there been any notable changes in the way you create art or graphics I would say one big difference is that I am planning things out a bit more in the sketch phase and doing small tests with different light source options on paper before then moving on to create the final image While this makes things a bit more planned out in the beginning the process of adding the shadows at the end feels very freeing for me and I am always surprised by how the final result turns out Were you given a brief with your latest work they are part of a running series for a club concept here in Oslo called Cosmic Oslo where I collaborate with a graphic designer friend In the posters we are asked to create images that channel the spirit of the cosmic disco being played The inherent sci-fi themes and sounds from a lot of the records being played at these club nights give us a pretty big universe to play in that feels right at home with me I often try to sift through campy sci-fi concepts that I can twist in a new direction Is there a particular message you’re trying to convey I am often playing around with ideas based around reality consciousness and identity framed through the lens of some sort of character in a surreal situation This is more of an unconscious thing that I can identify while looking back I guess I have my high school years to thank for colouring my approach as I was obsessed with Rene Laloux and Moebius Derek Ercolano & Bendik Høibraaten: Cosmic Oslo Spring 2017 Derek Ercolano & Bendik Høibraaten: Cosmic Oslo Winter 2017 Ayla Angelos Ayla is a London-based freelance writer After joining It’s Nice That in 2017 as editorial assistant she was interim online editor in 2022/2023 and continues to work with us on a freelance basis and she is also the managing editor of design magazine Anima Fancy a bit of It's Nice That in your inbox Sign up to our newsletters and we'll keep you in the loop with everything good going on in the creative world Instagram TikTok LinkedIn Facebook Twitter Pinterest About Careers at It’s Nice That Privacy Policy Insights Residence Creative Lives in Progress If You Could Jobs © It’s Nice That 2024 · Nice Face Logo © It’s Nice That Ayla is a London-based freelance writer www.fragile-magic.com\n@fragilemagic When we last wrote about Derek Ercolano’s work physicality-led practice reminds its audience of the person behind the piece In the newest instalment of his illustrated series Brian Blomerth explores the life of John C Lilly – the scientist that used ketamine to speak to dolphins Aysha Tengiz received a questionable contract asking her to give up rights to her own intellectual property the illustrator explains why that’s such dodgy practice and why creatives need to be more clued up about copyright Cofounded in 2022 by food industry creatives Cake Zine is back with its sixth issue: Daily Bread About Contact 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POV Forward Thinking Review of the Year Jenny Brewer Olivia Hingley Ellis Tree Elizabeth Goodspeed Liz Gorny Instagram TikTok LinkedIn Facebook Twitter Pinterest Careers at It’s Nice That Privacy Policy Insights Residence Creative Lives in Progress If You Could Jobs Thanks for visiting one of downtown Redding’s oldest retail stores is closing later this spring after more than 25 years in business Owners Denise Craig and Kelli Ercolano said they have talked about retiring for a couple of years and decided now is the time They bought the store from the original owner in 2000 “We have had the store for 21 years and we just felt like even before COVID happened that we were going to retire this year The store on Market Street is currently hosting a retirement sale Ercolano said they plan is to close after business April 30 “But it will depend on both what we have in inventory left and what tenant comes in and when,” she said They own the building and are currently searching for a tenant that will lease it out Boardmart was established in 1995 by Ben and Jean Mattox and then purchased by the Craig and Ercolano families five years later Denise Craig worked for Ben Mattox at Alpine Outfitters before she helped opened Boardmart 26 years ago The store has been a family affair for years works at Boardmart and on Wednesday was doing snowboard tune-ups Both Denise Craig and Kelli Ercolano said they will miss their customers “All this time there is people we see every season whether they are water or snow (enthusiasts) or both we just made a lot of friends through the business,” Ercolano said Said Craig: “We have met a lot of great people coming in and supporting us so that is what we are going to miss the most.” RELATED: 'This is a good feeling, honestly': Redding celebrates Market Street reopening Craig and Ercolano have championed downtown and have watched the city’s old core experience growing pains Their decision to close comes as the city recently reopened Market Street to vehicle traffic about a block from Boardmart’s front door “It’s really good to see and I really like the way it looks,” Ercolano said “I think they did a really good job blending the new with the hold … It would have been nice if it would have been earlier Craig said they both plan to stay in Redding and will enjoy watching downtown grow and prosper We are just happy to be a part of it,” she said While they are not closing due to the pandemic Ercolano said it’s been challenging for a small business like theirs It was really scary for a while,” she said it didn’t hit us hard like a lot of restaurants and other businesses.” With plenty of snow in the mountains keeping Mt Craig said this winter season has been good for Boardmart The store does most of its business in the winter RELATED: Some small businesses in Redding hang by a thread as the pandemic grinds on "It's been a really good year for snow," Craig said We "decided it would be great to go out on a good note when everything business wise is going well." Ercolano per la legalità (Ercolano for Legality) was inaugurated in 2006 by the local administration and was headed by one of the businesspeople who had rejected the pizzo Discussions held at the association and attended by businesspeople the Carabinieri and the local administration made it clear that there was a disconnect between the three groups responsible for tackling the crime Not only was there a lack of denunciations it also became evident that the Carabinieri had not done enough in the past to support the businesspeople who had showed the courage to report their extorters leaving them to be approached by different extortionists instead The business community simply did not trust the Carabinieri to protect them in the period following any potential trial leaving them exposed if they were ever to report their extorters Occasional mass arrests in the preceding years had done little to tackle the clans instead creating vacuums that were filled by other rival groups These arrests had little effect on the norm of pizzo payment other than to force businesspeople at times to pay multiple clans a novel strategy that encouraged businesses to denounce their Camorra extortionists was therefore adopted the lieutenant of the Carabinieri began visiting the businesses one-by-one assuring them that they could denounce the clans without concerns for their safety Whilst the anti-racket movement continued to meet and many businesses remained unwilling to go out on a limb on the word of some Carabinieri lieutenant ‘most of [the businesses] already knew… they would even have the envelope [of money] ready… they would pay without discussion… everyone paid… there wasn’t anyone who didn’t pay’ the area was regarded as the model case for how to defeat mafia racketeering: the Ercolano Model “They would pay without discussion… everyone paid… there wasn’t anyone who didn’t pay” I set about studying an anti-mafia movement that had successfully uprooted its local criminal associations I wanted to know how a community with deeply rooted norms of pizzo payment was able to overcome omertà the silence that often prevented businesses from denouncing their extorters and what could be learned and applied to cases elsewhere I wanted to know what other efforts were being made in the streets and by community associations to challenge the Camorra and the cultures that encouraged young people to join this world I did this through a long-term ethnographic study applying a grounded approach that was followed by interviews with figures in the local anti-Camorra movement that I identified during fieldwork This involved interaction with the shopkeepers themselves members of local Civil Society associations such as Church parishes youth associations and overtly anti-Camorra associations combined with daily interactions working and living as an English teacher in the area important than repression by law enforcement agencies in uprooting criminal associations This was particularly the case given that much of their power relied on deeply rooted norms present in these areas What this situation required was deeper social and cultural change The distrust that characterised the shopkeepers’ view of the Carabinieri was overturned with the Carabinieri proving that they could be relied upon and were fighting on the same side Dr Chris Bowkett is a recent PhD graduate at the University of Bath His research interests include the anti-mafia movement in Italy and organised crime more broadly Main image credit: Del-Uks, via Flickr The views expressed in this article are those of the author(s) and do not necessarily reflect the views of RUSI or any other institution Del-Uks Copyright 2025 | The Royal United Services Institute for Defence and Security Studies | RUSI is registered as a charity in England and Wales - Charity number: 210639 | VAT number: GB752275038 Volume 6 - 2015 | https://doi.org/10.3389/fpls.2015.00987 Our understanding of plant–pathogen interactions is making rapid advances in order to address issues of global importance such as improving agricultural productivity and sustainable food security resulting in a wide diversity of defense mechanisms adapted to specific threats The postulated PTI/ETI model describes two perception layers of plant innate immune system which belong to a first immunity component of defense response activation To better describe the sophisticated defense system of plants This model considers the plant’s ability to distinguish the feeding behavior of their many foes such as a second component that modulates innate immunity This hypothesis provides a new viewpoint highlighting the relevance of hormone crosstalk and primary metabolism in regulating plant defense against the different behaviors of pathogens with the intention to stimulate further interest in this research area also known as a non-specific immune system defends the host from infection by other organisms in a non-specific manner Two different resistance directions are supposed to be activated in a multi-trophic interaction Once a plant containing a R-gene (different green shades) comes in contact with biotrophic or necrotrophic pathogens only an incompatible interaction will activate the plant resistance the interaction spaces of plant resistance (green triangle) and of biotrophic and necrotrophic pathogens (blue and red rectangles The intersections of interaction spaces identify three plant–pathogen interaction areas: two are pathogen lifestyle-related (small black triangles) and one is common (violet circle) The synergic effect of immunity activation and of pathogen lifestyle-dependent components result in plant immunity to biotrophic or necrotrophic pathogens Once a plant comes in contact with a biotrophic or necrotrophic pathogen, only an incompatible interaction will create an exchange of information necessary to activate the plant resistance. The feeding behavior of the pathogen also influences the activation of a second immunity component that is responsible for the differential modulation of the resistance, which will drive the resistance in right direction (Rolland et al., 2006). In Figure 1 two small black triangles depict the overlapping areas between host (green triangle) and biotrophic/necrotrophic pathogens (blue and red rectangles that initiate the IAC converging in the pathogen-specific plant immunity The model schematically shows the key points of activation and modulation of plant immunity Plant resistance mechanism of an incompatible interaction might be divided into three phases: (1) interaction two principal effects are detected: (A) modifications of virulence factor targets and (B) specific alterations of primary plant metabolism In the activation stage: the modifications of virulence factor targets induce the Nibblers Triggered Signaling (NTS) or PPRs Triggered Signaling (PTS) These metabolic alterations induce a feedback regulation of primary metabolic pathways resulting in a Hormone Tempered Resistance (HTR) and the HTR converge to confer a resistance specific to the lifestyle of pathogen (Pathogen lifestyle-Specific Resistance the specific lifestyle of pathogens requires a specific response the IAC and the Immunity Modulation Component (IMC) converge in a unique response of resistance specific to the lifestyle of pathogen (Pathogen lifestyle-Specific Immunity Our IAC/IMC model presents a schematic representation of plant innate immune components in which plant hormones play a leading role in determining the outcome The plant possesses an internal and external receptor repertoire that can activate prompt pathogen recognition Plant global awareness requires a metabolic response directly bearing on the established interaction More studies are necessary to identify additional components involved in defense responses as well as a detailed characterization of the mechanisms underlying such responses Conceived and designed the model and was centrally involved in manuscript writing: GA Elucidated the meaning and revised the paper: MRE Both authors read and approved the final manuscript This research was carried out within the GenoPOM-Pro Project funded by the Italian Ministry of Education The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest Michael Van Oosten for language editing and Dr Paolo Iovieno for proofreading the manuscript and for assistance with the figures Tomato genome-wide transcriptional responses to Fusarium wilt Global switches and fine-tuning: ABA modulates plant pathogen defence Abscisic acid determines basal susceptibility of tomato to Botrytis cinerea and Sugars and suppresses salicylic acid-dependent signaling mechanisms Metabolomics of cereals under biotic stress: current knowledge and techniques Role of plant hormones in plant defence responses Biotic stress globally downregulates photosynthesis genes A renaissance of elicitors: perception of microbe-associated molecular patterns and danger signals by pattern-recognition receptors doi: 10.1146/annurev.arplant.57.032905.105346 Bolouri-Moghaddam Primary metabolism and plant defense – fuel for the fire Plant-parasite coevolution: bridging the gap between genetics and ecology Plant immunity: towards an integrated view of plant-pathogen interactions The metabolic interplay between plants and phytopathogens Contrasting mechanisms of defense against biotrophic and necrotrophic pathogens doi: 10.1146/annurev.phyto.43.040204.135923 Plant disease resistance genes: current status and future directions Danger signals – damaged-self recognition across the tree of life The zig-zag-zig in oomycete-plant interactions Intervention of phytohormone pathways by pathogen effectors Pathogen recognition by the innate immune system Unique characteristics of Xanthomonas oryzae pv oryzae AvrXa21 and implications for plant innate immunity Signaling from an altered cell wall to the nucleus mediates sugar-responsive growth and development in Arabidopsis thaliana Investigating the functions of the RIN4 protein complex during plant innate immune responses Salicylic acid in plant defence—the players and protagonists López-Gresa Metabolic response of tomato leaves upon different plant–pathogen interactions Molecular diversity at the plant-pathogen interface Plant pattern recognition receptor complexes at the plasma membrane The outcomes of concentration-specific interactions between salicylate and jasmonate signaling include synergy and oxidative stress leading to cell death Networking by small-molecule hormones in plant immunity Robert-Seilaniantz Hormone crosstalk in plant disease and defense: more than just jasmonate-salicylate antagonism Source-sink regulation by sugar and stress CrossRef Full Text | Google Scholar Regulation of primary plant metabolism during plant–pathogen interactions and its contribution to plant defense Sugar sensing and signaling in plants: conserved and novel mechanisms doi: 10.1146/annurev.arplant.57.032905.105441 The receptor for the fungal elicitor ethylene-inducing xylanase is a member of a resistance-like gene family in tomato Green leaf volatiles: a plant’s multifunctional weapon against herbivores and pathogens Photosynthesis and carbohydrate metabolism in tobacco leaves during an incompatible interaction with Phytophthora nicotianae Coordinated plant defense responses in Arabidopsis revealed by microarray analysis CrossRef Full Text | Google Scholar Expression of the Bs2 pepper gene confers resistance to bacterial spot disease in tomato Differences in cell death induction by Phytophthora elicitins are determined by signal components downstream of MAP kinase kinase in different species of nicotiana and cultivars of Brassica rapa and Raphanus sativus Of PAMPs and effectors: the blurred PTI-ETI dichotomy Vitamin D controls T cell antigen receptor signaling and activation of human T cells Mechanical stress induces biotic and abiotic stress responses via a novel cis-element Transcript profiling in host-pathogen interactions doi: 10.1146/annurev.phyto.45.011107.143944 CrossRef Full Text | Google Scholar A maize resistance gene functions against bacterial streak disease in rice Citation: Andolfo G and Ercolano MR (2015) Plant Innate Immunity Multicomponent Model Copyright © 2015 Andolfo and Ercolano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) or licensor are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Maria R. Ercolano, ZXJjb2xhbm9AdW5pbmEuaXQ= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish The bride-to-be graduated from Secaucus High School in 2005 and Montclair State University in 2010 She is employed as a design assistant for Marie Chavez Jewelry in Montclair The groom-to-be graduated from Vernon Township High School in 2006 and Montclair State University in 2011 He is the owner of Snap Fitness in Flemington a baseball instructor for Garett Teel's baseball school in Wyckoff and head catching instructor and coach for West Morris Baseball Academy in Randolph has become the first town to stop paying extortion money to the Camorra A new freedom fiercely defended by the town's mayor and shopkeepers Not even the pastor of the Church of the Santísimo Rosario (Holy Rosary) escaped three generations of residents of Ercolano a town of 55,000 located 14 kilometre from Naples have done only one thing: grit their teeth and stump up extortion money of between 150 and 1,500 euros every month that the members of the local Camorra demanded from the traders in exchange for not making their lives impossible half way between the sea and Vesuvius and famous for its Roman ruins has said "Enough!" and so has become the first town in southern Italy that has dared to give the finger to the mob and refuse to yield to their extortion rackets territory freed of extortion," will defiantly proclaim a sign soon to be put up prominently at the entrance to the town "We no longer put up with abuses," proudly declare the banners hanging from many shop windows according to the SOS Confesercenti association extorting “pizzo” – the term for the ‘tax’ the Mafia impose on shopkeepers backed up by threats and intimidation – brings some 10 billion euros each year into the coffers of organised crime in Italy and affects about 160,000 companies "We’re free of it now in Ercolano,” says Giuseppe Scognamiglio a station that speaks out against the Mafia and for the law The station began broadcasting in 2009 from offices in what had been the headquarters of a local Camorra boss It was made possible by Voxeurop’s community High-quality reporting and translation comes at a cost To continue producing independent journalism Subscribe or Donate mobsters were walking down the street armed and driving about in armoured cars mounted with machine guns and people were literally scared to death." Ercolano's rebellion against the criminals began in 2004 when for the first time in the history of the town an entrepreneur dared to go to the security forces and report that a mobster had come into her shop and demanded money in exchange for not making life difficult for her That bold shopkeeper is a flirtatious blonde lady but up until that time they had never tried to extort from me When that guy came to my shop and told me in a threatening tone that I had to pay up I was afraid "But I thought it was better to close the shop than to live the rest of my life with that fear and I went straight to the police station to report what happened” “It’s better to die once than to die every day.” The heroic act of Raffaella Ottaviano proved a memorable one Especially since other business people who had dared to stand up to the Mafia had paid dearly for their audacity who owned a bread bakery in the centre of Ercolano Not only did the gangsters come one day to wave a gun to persuade her it was better to pay when a man named Nino Daniele was elected mayor of Ercolano which was then immersed in a bloody war between two Camorra clans that saw about one killing a week and where traders were being suffocated by the “pizzo” but plenty of shops had been forced to close up because they couldn’t handle that burden All the businesses in the town were in crisis Ercolano was going through an economic and human drama I had to do something,” the former mayor of the town recalls and for the four years he was mayor worked hard to try to rebuild the trust of the inhabitants of Ercolano in the institutions and in the state He not only dared to stand up and speak out against the mobsters marching at the head of numerous popular demonstrations against them he cancelled each and every municipal contract with companies suspected of being related to the Camorra began to fight against the real-estate abuses so typical of organised crime and dared to take part in many civil cases against camorristi.. He also brought in measures to encourage merchants to refuse pay the pizzo passing for example a law that exempts them from all local taxes for three years in exchange for reporting extortion by the Mafia he spearheaded the Ercolano Association against Mafia Extortions The results have been striking: the law enforcement and judicial operations have put around 250 mobsters from Ercolano behind bars today A total of 23 local businessmen who had to pay off the mob have summoned up the courage to denounce 41 members of organised criminal gangs and to take part in the legal actions now underway against them Voxeurop depends on subscriptions and donations from its readers The World Heritage Centre is at the forefront of the international community’s efforts to protect and preserve World Heritage partnerships for conservation Ensuring that World Heritage sites sustain their outstanding universal value is an increasingly challenging mission in today’s complex world where sites are vulnerable to the effects of uncontrolled urban development Our Partners Donate Take advantage of the search to browse through the World Heritage Centre information. 公元79年8月24日维苏威火山的爆发，吞没了两个繁盛的罗马城市：庞培和赫库兰尼姆以及那个地区的许多富家别墅。从18世纪中叶始，被掩埋的一切都逐渐挖掘出来并向公众公开开放。庞培商业城的广阔，与规模不大却保存完好的赫库兰尼姆假日胜地相得益彰，而托雷安农齐亚塔的奥普隆蒂斯别墅的壮丽壁画，呈现给我们一幅早期罗马帝国富裕的市民生活方式的生动画面。 Pompeii, with its well-preserved buildings in an excavated area of 44 ha, is the only archaeological site in the world that provides a complete picture of an ancient Roman city. The main forum is flanked by a number of imposing public buildings, such as the Capitolium, the Basilica and temples and within the city there are also many public bath complexes, two theatres and an amphitheatre. Herculaneum’s urban districts and seafront display a higher level of preservation with noteworthy conservation of upper floors thanks to the pyroclastic material that buried the town. Organic matter was often carbonized by the high temperatures and exceptionally preserved finds include everyday objects such as foodstuffs, architectural elements and wooden furniture. The suburban villas across the Vesuvian area are perhaps even more exceptional in terms of the scale of their buildings and grounds, as well as their lavish decorations. The Villa of the Mysteries is an enormous residence just outside Pompeii’s city walls, developed from a modest house built in the 3rd century BC, named from the remarkable wall paintings in the triclinium, which depict the initiation rites ('mysteries') of the cult of Dionysus. There were many changes to these buildings over time in response to changing circumstances of the owners; these include repairs and adjustments that were a response to the seismic events that led up to the AD 79 eruption and reflect a community living with changing environmental and economic conditions. A special feature of Pompeii is the wealth of graffiti on its walls. An election was imminent at the time of the eruption, and there are many political slogans scrawled on walls, as well as others of a more personal nature, often defamatory. At Herculaneum, the volcanic deposits preserved hundreds of wax tablets, some of which conserve legal documents, and more than 1,800 papyri scrolls containing Greek philosophical texts were found at the Villa of the Papyri. The diverse range of literary sources available in Pompeii and Herculaneum provides a picture of the final decades of these ancient cities and the image of socially complex and dynamic communities, representing exceptional evidence of typical ways of life in Roman society in the first century AD and the importance of texts in political and private life. Another important legacy of the twentieth century was the presentation of Herculaneum to the public as an ‘open-air museum’, perhaps Europe’s first, with buildings reconstructed based on archaeological evidence and displays of original objects within the archaeological site. This concept of ‘open-air museum’ had already been adopted in some buildings in Pompeii, as a medium to communicate the meaning of ancient spaces, at the end of the 19th century. Criterion (iii): Pompeii and Herculaneum are the only Roman cities ruins preserved in such an exceptional way and have no parallels in integrity and extent in the world. The villas in Torre Annunziata have the best preserved wall paintings of the Roman period. Criterion (iv): The sites of Pompeii, Herculaneum and Torre Annunziata provide a full picture of Roman life from the 1st century BC to the 1st century AD through the urban, architectural, decorative and daily life aspects that have been preserved. The villa A in Torre Annunziata is the most significant example of suburban villa of the Roman period. Criterion (v): The sites of Pompeii, Herculaneum and Torre Annunziata are outstanding examples of urban and suburban Roman settlements. They also provide a vivid and comprehensive picture of Roman life at one precise moment: the eruption of Vesuvius in 79 AD. A general shift in conservation approaches in the 21st century is favouring authenticity; instead of concentrating on single buildings, conservation campaigns are focusing on entire districts of the ancient towns, consisting of one or more insulae, and so achieving a more coordinated and homogenous result. Despite the nature and quality of earlier restoration and reconstruction works, the authenticity of the individual components and the ancient urban and suburban fabric as a whole is very high. The property was protected by the provisions of past Law No 1089/1939 and since 2004 is under the Legislative Decree No 42/2004 (“Cultural Heritage and Landscape Code”). The perimeter of the Pompeii site is protected by the Decree of June 10th 1929. Environmental legislation in the form of the Legislative Decree No 42/2004 extended this protection to a wider area. All buildings and excavation works within the modern towns around the sites must be approved by the relevant heritage authorities. At Herculaneum, where most of the ancient city lies under the modern town, additional protection is offered by development restrictions of the high-risk zone of Mount Vesuvius and wider Regional territorial plans. The Vesuvius National Park also provides additional layers of protection of the broader setting while the MAB Biosphere designation provides a framework to promote further coordination. The 3 component parts are owned by the State and, together with the immediate surrounding areas, are managed by the Archaeological Park of Pompeii (also overseeing the villas in Torre Annunziata) and the Archaeological Park of Herculaneum, two autonomous institutions established recently as part of a broader ministerial reform which attempts to bring decision making closer to the sites themselves. These local heritage authorities include technical/scientific (archaeologists, architects, restorers), security and reception staff. Annual visitor numbers at the sites exceeds two and a half million (half of these are estimated to be foreign visitors). A major public-private partnership, the Herculaneum Conservation Project, has shaped conservation and site management and enhancement at Herculaneum since 2001. The ‘Grande Progetto Pompei’, approximately a 5-year project begun in 2012 with the European Union has, among other things, stabilized and conserved buildings in the areas of highest risk at Pompeii. Please enable JS and disable any ad blocker How to Visit the Archaeological Site of Herculaneum, Italy Volume 10 - 2019 | https://doi.org/10.3389/fimmu.2019.02801 This article is part of the Research TopicInnate Lymphoid Cells in Cancer: Friends or Foes?View all 12 articles Innate lymphoid cells (ILCs) represent the most recently identified family of innate lymphocytes that act as first responders maintaining tissue homeostasis and protecting epithelial barriers group 2 ILCs (ILC2s) have emerged as key regulators in several immunological processes such as asthma and allergy Whilst ILC2s are currently being evaluated as novel targets for immunotherapy in these diseases their involvement in tumor immunity has only recently begun to be deciphered we provide a comprehensive overview of the pleiotropic roles of ILC2s in different tumor settings we discuss how different therapeutic approaches targeting ILC2s could improve the efficacy of current tumor immunotherapies we discuss potential strategies to exploit ILC2 biology to improve the efficacy of current tumor immunotherapies Schematic representation of pro- and anti-tumor roles of ILC2s Summary of the known pro- and anti-tumor roles of ILC2s For bibliographic details refer to the work cited in the main manuscript These findings were also confirmed in an APL mouse model raising the possibility of finding the same axis in other tumors including solid tumors such as prostate cancer (see “ILC2s in prostate cancer” section) The use of tumor-bearing ILC2 KO mice transferred with ILC2s isolated from wild-type donor mice might represent a good strategy to dissect the contribution of ILC2s in the T-cell mediated anti-tumor responses These results highlight the concept that the BC immunosuppressive environment is driven by ILC2-derived IL-13 that may be contributing to the failure of current BC therapies the ratio between T cells and M-MDSCs may also have an impact on the response to treatment since patients with a high T cell/MDSC ratio show improved survival with reduced risk of recurrence more research is needed to better understand the role of ILC2s in this type of cancer no data is available to date on ILC2-derived AREG in CRC development and progression promote tumor growth upon IL-33 stimulation The authors show that mast cells are more abundant than ILC2s in gastric tumors and secrete macrophage-chemoattractant colony-stimulating factor 2 (CSF2) and IL-6 in response to activation by tumor-derived IL-33 In ST2 deficient animals (gp130FF ST2−/− mice) which was increased upon adoptive transfer of ST2+ wild type bone marrow-derived mast cells (BMMC) additional studies with adoptive transfer of ST2+ wild type ILC2s could help to determine the individual contribution of mast cells and ILC2s in this cancer setting it is still unknown whether ILC2s and ILC2-derived AREG are involved in this pro-tumoral axis The use of ILC2 KO mice could represent a strategy to address the role of AREG-producing ILC2s in the context of breast cancer The use of neutralizing antibodies directed against IL-5 may be useful to confirm the involvement of ILC2s in metastatic melanoma in the absence of sufficient data on the function of ILC2s in lung cancer it is too early to define their role in this setting Ultimately with constant new discoveries in the ILC2 field in health and disease immunotherapies focusing on the functional targeting of ILC2 are fast approaching clinical realization ST and CJ wrote and critically revised the manuscript All authors provided approval for publication of the manuscript This work was supported by grants from the Swiss National Science Foundation (PZ00P3_161459 and PR00P3_179727 the Swiss Cancer League (KFS-3710-08-2015-R and by the Ludwig Institute for Cancer Research Innate lymphoid cells–a proposal for uniform nomenclature Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity Systemically dispersed innate IL-13-expressing cells in type 2 immunity TSLP elicits IL-33-independent innate lymphoid cell responses to promote skin inflammation Characteristics of innate lymphoid cells (ILCs) and their role in immunological disorders (an update) Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues Influence of the transcription factor RORgammat on the development of NKp46+ cell populations in gut and skin Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells Correction: KLRG1 and NKp46 discriminate subpopulations of human CD117(+)CRTH2(-) ILCs biased toward ILC2 or ILC3 Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectinlike receptor G1 (KLRG1) Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity lineage-negative KLRG1(hi) cells are 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eosinophils in tumor immune surveillance Incidence and survival of hematological cancers among adults ages >/=75 years CD127+ innate lymphoid cells are dysregulated in treatment naive acute myeloid leukemia patients at diagnosis Intratumorally establishing type 2 innate lymphoid cells blocks tumor growth CrossRef Full Text | Google Scholar Recent advances in prostate cancer treatment and drug discovery The tumor microenvironment in prostate cancer: elucidating molecular pathways for therapy development Tyrphostin RG14620 selectively reverses ABCG2-mediated multidrug resistance in cancer cell lines CrossRef Full Text | Google Scholar Type 2 innate lymphocytes actuate immunity against tumours and limit cancer metastasis Epidemiology of bladder cancer: a systematic review and contemporary update of risk factors in 2018 EAU guidelines on non-muscle-invasive urothelial carcinoma of the bladder: update 2016 Advances in risk stratification of bladder cancer to guide personalized medicine and 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Trabanelli S and Jandus C (2019) ILC2s: New Actors in Tumor Immunity Received: 01 October 2019; Accepted: 14 November 2019; Published: 03 December 2019 Copyright © 2019 Ercolano, Falquet, Vanoni, Trabanelli and Jandus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited *Correspondence: Camilla Jandus, Y2FtaWxsYS5qYW5kdXNAZ21haWwuY29t †These authors have contributed equally to this work Millions of men saw combat during World War II Others were so far removed from the action that their guilt and regret endures to this day he wears a blue ballcap with the words “U.S Army Air Corps WWII Flyboy” stitched in yellow across the front it’s hard to imagine him in the cockpit of a fighter plane The cane doesn’t assist him in nursing an old war wound and periodic difficulty breathing due to problems with his lungs We had engine trouble and turned back,” says Ercolano who spent six months in the mainland United States preparing to be deployed to Japan “While we were waiting for the plane to be fixed Ercolano is one of four surviving World War II veterans at his local VFW post in St According to the Department of Veterans Affairs for every 16 Americans who served in the war only one is still alive; 2015 is projected to be the first year that the population of World War II veterans drops below one million After the reinstatement of the draft in 1940 (the only two previous times of mandatory conscription being World War I and the Civil War) around 10 million men were drafted into the war effort roughly 16 million Americans served in World War II Some 600,000 were wounded; 400,000 more were killed Ercolano says that for himself and his friends — teenagers at the time the draft was reinstated — the War didn’t instill fear warfare — as gruesome as it was — was the only activity that a normal guy could engage in some adventure.” On his childhood block alone (4th Street between Fifth and Sixth Avenues in Park Slope Ercolano remembers six neighbors who died in the war effort was killed serving as a gunner on a B-24 plane They got shot down over the English Channel,” recalls Ercolano Ercolano now considers himself lucky not to have seen combat having married his childhood sweetheart and fathered three children But this feeling of luck has come with much reflection and has changed drastically over the years Ercolano enlisted in the army in 1942 and was drafted into the Air Corps in 1943 He was jubilant at the prospect of adventure but his excitement never blossomed into lived experience Ercolano had spent much of his enlisted time working as the “kitchen police” and on guard duty at a military base in Nebraska At first, all he felt was anger. “We missed out,” he says. “You know the movie Mister Roberts?” he asked, referencing the 1955 film starring Henry Fonda about a World War II navy cargo ship that was far from the action. “That kind of describes what I went through.” “People are interested in combat.” It’s clearly a topic that has weighed on him over the last 70 years has been associated with virility and masculinity,” says David M Professor of History at the Bill Lane Center for the American West at Stanford University “The ultimate test of manhood is armed combat That’s an old trope that goes back to Homer.” and was of a draftable age in the Vietnam era “There’s kind of a code amongst people my age When you meet someone new you quickly see whether you’ve served or not,” says Kennedy of social situations where he’s watched men bond over their military service “I don’t know the code because I wasn’t there.” Kennedy’s father was born in 1896 and didn’t serve in either World War I or II “He said he was too young for the first war and too old for the second war But it turns out that wasn’t true,” says Kennedy It was only when his father turned 80 that Kennedy learned that his father was actually physically unqualified to serve which classified men based on characteristics such as health and whether they enlisted or were drafted was IV-F; reserved for those with physical defects Kennedy says his father admitted to him during conversations about why he hid the truth ‘What are you going to say when your kid asks grew up with World War II a constant presence in his youth every male relative served in World War II “Your minister in church was a World War II veteran your school teacher was a World War II veteran,” says Kolb Pop culture was much the same: “Growing up in the 1950s you would have been exposed to a tremendous number of World War II movies.” Kolb says that growing up in the wake of World War II greatly impacted his decision to enlist in the Vietnam War in 1969 a Vietnam Veteran and the Assistant Adjutant General for the Veterans of Foreign Wars he’s met men who feel guilty for not having served in Vietnam Newberry can relate to the feeling of exclusion among those who haven’t served or seen combat “I can only imagine that if your peer group and your neighbors and the majority of males in your age group were serving in the military and you weren’t Newberry’s stepfather was a World War II veteran who drove a landing craft in the Pacific Ocean He wouldn’t go into any detail about that,” Newberry says But his stepfather’s pride was obvious to Newberry He had a tattoo on his forearm of Betty Boop with an anchor and gave warm welcomes to those who had also served “I think World War II was absolutely the last time the country came together not only militarily he’d meet somebody his own age and they’d start talking,” Newberry remembers the Military and Veterans Affairs Consultant to the President of the National WWII Museum in New Orleans says that the culture after the war was not one that encouraged open None of them got a scratch,” says Detweiler “We have people at the museum today who still don’t really talk about it,” says Detweiler “They’ll come in to the museum with their families They’ll see exhibits that remind them of their service and that’s when they start talking about it for the first time.” lived in Brooklyn during the war’s early years She recalls a dearth of men on the streets Most people seemed to have a family member or close friend overseas Anne was encouraged to enlist by a friend of hers in 1943 “I thought it would be exciting,” she remembers where she kept records of the enlisted men — a job she took from a man who was being deployed overseas Anne volunteers that her husband’s lack of combat doesn’t bother her “I never thought about it.” Her husband Dominic has thought about it — a lot — but has accepted his fate and moved on I had come back so I could marry my childhood sweetheart,” he beams pointing to old black and white photographs of the pair on their honeymoon Anne and Dominic have been married for 65 years “I feel like that couldn’t have all happened by accident.” Rebecca White is Narratively's Director of Operations as well as an editor and regular contributor to the publication Her work has appeared in such outlets as The New York Times and Al Jazeera America This story was created in partnership between The Wilson Quarterly and Narratively. How a 70-year-old massacre continues to haunt a nation. Design and code by Marquee The TimesAn ancient Roman fresco from Herculaneum that depicts an infant Hercules strangling a snake has been returned to Italy after being confiscated in the United States Known as the Ercolano Fresco and valued at $1 million the work was one of 48 antiquities seized from Michael Steinhardt who is a hedge fund manager and one of the world’s most important collectors of ancient art The fresco, which dates from AD50, was looted from a villa in Herculaneum in 1995 and purchased the same year by Steinhardt for $650,000 with — according to US prosecutors — no verifiable provenance Steinhardt undertook to refrain from acquiring antiquities in the future in exchange for immunity from prosecution Like its larger southern neighbour Pompeii It's easy to make - just mix an ingredient in prescription cough medicine with some caustic household chemicals one of the drugs that escaped Duval County jail inmate Debra Ercolano said she regularly used before she died late Monday also is like "playing Russian roulette," according to at least one local medical official called the Jacksonville Sheriff's Office on Monday to turn herself in after she ran away Thursday from a Lane Avenue work program she complained about feeling ill and was hospitalized "It sounds like she had some responsibility in her lack of care for herself she did have a history of some heart issues as well." So named because it turns a user's skin green and scaly before it rots off krokodil sets "a new standard for fast destruction of mind an international substance-abuse organization it isn't showing up yet as a cause of death in American medical examiners' statistics But local police are aware of it as poison control center officials worry about a drug cooked up at home with deadly chemicals "They don't purify it very well when they make it at home and the products they mix it with are corrosives They rot away the flesh at the injection site," said registered nurse Debi Forrest the education coordinator at the Florida/USVI Poison Information Center at UF Health Jacksonville "It is not being reported in Florida and there have only been a few cases documented in the U.S.," she said The reason why it is so popular [in Russia] was because codeine was available over the counter 25 on a warrant for organized fraud after 29 bottles of vodka gin and tequila were shoplifted in January from a Walmart on San Pablo Road She was transferred to a Lane Avenue community transition center work program in mid-March she was cuffed and back in custody at the jail at 4:30 p.m As she was being brought next door to the Sheriff's Office where she gave medical officials a rundown on what she had taken and she also gives history of being a meth user being a cocaine user and being a heroin user and also using a drug called krokodil," Hackney said it did its thing and began to work on her." The drug can be cooked at home in 30 minutes using prescription codeine It is very cheap and it is easy to make," Forrest said "You can make it in your own home and that is the draw People run out of money for heroin and they may resort to this." fingers rotting off and even multiple amputations It is so caustic that users don't usually live more than a few years Krokodil doesn't show up as a cause of death in the Florida Medical Examiners Association's interim 2015 report on drugs identified in deceased people The drugs that caused the most deaths were benzodiazepines (558 The National Drug Threat Assessment Summary from 2014 stated no confirmed cases of krokodil abuse in the United States Forrest said poison control centers in Florida haven't recieved any calls about it but are ready to consult on it Johns counties all said they were aware of the drug but hadn't seen a trend here .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Peter Genovese | NJ Advance Media for NJ.comAristide EconomopoulosNatale Rescigno and Pasquale Iengo owners of Salumeria Ercolano in Jersey City Salumeria Ercolano in Jersey City is located hard by the train tracks leading into nearby Journal Square Walk inside and you’ll find one of the more peculiar dining spaces anywhere Four thousand square feet worth; the first-time visitor is not sure if this is deli as warehouse The 20 or so tables are scattered around the cavernous store along with shelves stocked with imported pastas and enough beverages to slake a small army’s thirst “We wanted the biggest deli in Jersey City,” co-owner Pasquale Iengo said unabashedly “Most of these delis in Jersey City are like a shoebox There are two or three tables on top of each other.” The deli sandwiches and panini are named after Jersey City streets — Sip Grilled chicken sandwiches are practically a Jersey icon; here the chicken is burnt slightly around the edges Some meats are born to be burnt; chicken is one of them tomato and mayo (I held the mayo; never understood mayo on roast beef) I asked for a JFK (named after the boulevard not the president) but got the Newark ($7.95 roasted red peppers and balsamic vinaigrette The mozzarella is made on the premises two or three times a day perfect for these sandwiches — is from Calandra’s which also supplies the cheesecake and carrot cake Panini include the Pavonia (grilled portobello mushrooms lettuce and tomato; and the Van Winkle (the avenue “This I wanted to do a long time ago,” Iengo said of his deli Bring plenty of friends — there’ll be room for all of them Peter Genovese: (973) 392-1765 or pgenovese@starledger.com Use of and/or registration on any portion of this site constitutes acceptance of our User Agreement, (updated 8/1/2024) and acknowledgement of our Privacy Policy, and Your Privacy Choices and Rights (updated 1/1/2025) © 2025 Advance Local Media LLC. All rights reserved (About Us) The material on this site may not be reproduced except with the prior written permission of Advance Local Community Rules apply to all content you upload or otherwise submit to this site YouTube's privacy policy is available here and YouTube's terms of service is available here Ad Choices Barbara Ercolano’s research focuses on understanding planetary formation.Credit: LMU Munich “You’ll be able to breathe physics on our new campus,” says Barbara Ercolano Over the next ten years she and colleagues from across the university will move to a new Bringing together research and teaching on subjects including nanotechnology the new campus will cement LMU Munich’s reputation as a leader in the field The new physical environment is intended to encourage the kinds of social interactions that spark creativity and insights “Both staff and students will benefit from the kind of informal conversations that lead to new ideas,” says Ercolano and on understanding the conditions that produced the wealth and diversity of planetary systems in our galaxy “We run large-scale computer simulations of the birth environments of planetary systems and compare the results with observations from ALMA (the Atacama Large Millimeter Array in northern Chile),” she explains After a star is born from interstellar clouds the leftover gas and dust forms a disc around the star The process of planet formation is strongly influenced by the dynamics of dust and gas in the disc as well as by the irradiation from the young star planets form from the continuous collision of dust particles,” Ercolano says This research aims to help determine the conditions required to form a habitable planet like Earth but maintaining the conditions for life to persist and evolve is very difficult,” she adds LMU Munich’s new physics campus will border the largest urban park in Europe and the new site opened its first building last year largely funded by the Bavarian government’s green energy initiative SolTech offers state-of-the-art facilities to help scientists find ways to harness the unique properties of nanomaterials with a focus on photonics and energy sciences at the nanoscale Stefan Maier’s team is researching how light interacts with nanostructures.Credit: LMU Munich and a large variety of characterization laboratories with laser facilities spanning from the UV to the terahertz,” says nanophotonics researcher Stefan Maier who moved to LMU in 2018 after a decade at Imperial College London “LMU’s Physics Department is probably one of the most exciting places in Europe at the moment,” he adds the university’s physics faculty received funding from the German Research Foundation (Deutsche Forschungsgemeinschaft DFG) to develop three Clusters of Excellence around energy (e-conversion) quantum science and technology (MCQST) and the origins of life and the universe (ORIGINS) “This funding will consolidate long-term research programmes in these fields and further enhance the department’s international reputation,” says Maier Many Nobel Prize-winning physicists have studied “The university played a key role in the development of quantum mechanics,” says Maier semiconductor physics and biophysics really took off here.” his team focuses on modifying how light interacts with nanostructures “We are working on new and efficient ways to harvest light into very small areas to enhance energy conversion,” he says They are also exploring applications in optoelectronics and sensing technologies His group’s latest paper in Nature Nanotechnology describes a holographic video display based on surfaces with a distinct nanostructure arrangement that greatly enhances storage capabilities The breakthroughs of the 21st century will come from cooperative and interdisciplinary research “There is already a very strong collaborative environment here at LMU and we also have The Technical University of Munich (TUM) and the Max Plank Institute on our doorstep,” he adds “Easy access to such wide-ranging expertise is particularly useful for students.” Tapping into local expertise helps young researchers as well Ercolano joined LMU Munich in 2010 after working in the UK and the US Moving to Germany was not an easy decision “The research environment in Munich is so rich There are so many opportunities for young researchers and LMU is incredibly supportive,” she says Ercolano started in the UNIVERSE excellence cluster “This gave me the opportunity to meet researchers in different areas of physics fundamental questions rather than being limited to those that I could approach working on my own.” Ercolano has been teaching in English in the LMU’s master’s programme and will start teaching a bachelor degree course in German next semester LMU Munich offers two bachelor's degrees and four master's degrees across a diverse range of physics topics The master’s programmes include a 12-month research project that gives students the skills and experience they need to pursue further research in industry or academia Click here for further information .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Independent PressJoAnne and Roman Szymansky of West Milford are pleased to announce the engagement of their daughter Melissa is a 2006 cum laude graduate of Boston University and received a J.D She is an assistant prosecutor in Hudson County Thomas graduated from Lafayette College in 2007 and received a J.D He is a deputy attorney general for the State of New Jersey DraftKings continues to shape the gaming landscape with its innovative platform that offers fans a blend of strategy and excitement (Photo Illustration by Budrul Chukrut/SOPA Images/LightRocket via Getty Images) who created the fantasy football “lifestyle brand” BDGE based in Brooklyn began blogging about fantasy football as an 18-year-old and quickly realized his passion was behind the microphone whose personal brand started with creating content on YouTube that initially focused on fantasy football but later expanded to other areas such as gambling and lifestyle “It wasn’t like I just one day woke up and decided I’m quitting my job and I’m going after this thing.’ It was year after year,” Ercolano said “I had seen the growth be progressive and money started coming in not at a high level but enough to the point where I felt like I had momentum.” a subset of the the fantasy sports games that were popularized in the 1980s is a booming industry thanks to a 2018 U.S Supreme Court ruling that opened the door to legalized sports betting an opportunity 38 states and the District of Columbia have embraced A January 2023 report suggested the fantasy sports betting market will reach $56.36 billion by 2030 “I believe the DFS and sports betting growth will continue,” said Ben Fawkes an American sports betting radio network and streaming television channel since it’s been around a little longer it’s legal in a lot more states than sports betting While its growth has brought many great entertainment Ercolaho created content on the Draft platform before the company changed its name to Underdog because he enjoyed making fantasy football draft content using the website “Underdog’s and (my) relationship is extremely organic probably one of the more organic relationships I feel like I’ve had when it comes to partnerships,” he said A clip Ercolano posted on X (formerly known as Twitter) that showed him using the Draft app caught the attention of Draft’s vice president of marketing they were owned by the same parent company (FanDuel),” Ercolano said “And I was brought into the office one day which at the time was cool because that was my first partnership And I got to go into the FanDuel office.” Ercolano partnered with Underdog that summer and has been affiliated with the company ever since “Most of the time when you’re working with these companies at least when you’re a little bit of a higher level partner with them where they don’t want you working with other companies in the space,” he said had been around gambling his entire life and took the opportunity to edit gambling content through an internship during his senior year of college “And I think it was always something that interested me in college I was (Economics and Psychology) as a dual major and I think sports betting is pretty much at the intersection of those two things.” Fawkes interned at ESPN The Magazine editing gambling content from Chad Millman’s podcast He parlayed that into a career as a digital content creator promoting ESPN Chalk and helped promote VSIN’s brand by running their website social media and subscription products creating preview guides for the NFL “There was very clearly an audience that was gambling not legally because it was only legal in Nevada at that time,” he said “But the point was that we knew there was an audience there “It was about growing that organically and then eventually getting buy-in from people higher up that they were comfortable producing more of that content.” Daily Fantasy Sports has become immensely popular in the Southwest since the legislation of sports betting in September 2021 The tectonic moves encapsulate how the betting markets are carving their niche in an untapped industry that caught steam just a decade ago As the fantasy sports arena evolves, PrizePicks emerges as a frontrunner with its simplicity, strategic gameplay and unique appeal that distinguishes it in the competitive world of sports betting. (Graphic by Peyton Gallaher/Cronkite News) The difference between daily fantasy sports and a classic fantasy football league is how the rosters are constructed. In DFS the contest typically lasts a single day to a week The roster sizes in DFS allow teams to be constructed week-to-week rather than drafting a team and keeping it for the entire season as one would in a typical fantasy league Aside from the cash prizes, some fans enjoy watching sports more when a financial incentive is involved, according to the National Center for Biotechnology Information The Fantasy Sports Gaming Association (FSGA) advocates for fantasy sports legislation that adheres to core principles: fantasy sports is a game of skill and should not be legally regarded as gambling Each contest requires participants to create a new team and participants cannot exceed the salary cap of $50,000 for one team Sports betting and daily fantasy sports are intertwined because the two biggest sports betting sites, FanDuel and DraftKings, have invested in DFS, which requires participants to build their own lineup to play against other competitors where participants wager for or against particular outcomes Daily fantasy sports and sports gambling both have great potential for growth across Arizona fueled by a surge in marketing campaigns that target online gamblers significantly more And Arizona’s legalized gambling also attracts bettors from outside its borders or people from Nevada driving across the border,” Fawkes said we saw that when New York didn’t have mobile betting and New Jersey did people were going across the GW (George Washington) Bridge or taking the PATH train to New Jersey to place their bets and then coming back “So that’s probably more in terms of the growth The fact that it’s legal in some places and not legal in other places and knowing that there’s demand for it.” Due to Arizona’s emergence into a gambling paradise concerns about ethics and addiction have been brought into sharp focus The National Council of Problem Gambling has been tackling daily fantasy sports issues dating back to 2013 DFS has been a controversial topic for a while as state legislatures are addressing the issue of its legality and whether or not fantasy games should be considered gambling which hasn’t been decided across most states Growth of sports gambling blows Arizona’s doors wide open it’s to try and win something to gain an advantage program director for KindBridge Behavioral Health In 2023, the global fantasy sports market was projected to grow at 9% annually through 2027, and North America is projected to be the largest region impacted This becomes a tough hill to climb for health service companies but they understand they need to continue to have therapists certificated as gambling specialists and continue to create those networks and provide supervision And it is similar to the gaming industry,” Hatfield said “Video games have a huge trajectory of an increasing volume of net worth that you could be concerned about in the future.” One of the biggest issues that has emerged is the age at which gamblers begin participating in fantasy sports and other gaming it begins with something that can be purchased at any convenience store – scratch-off lottery tickets which require only scratching off boxes to win or lose “We’ve seen a higher increase for the 18-19 year olds,” said Michelle Hatfield in my experience of talking with a couple of them a lot of their beginning gambling behavior starts with scratchers who is working with an inpatient treatment program in Prescott “And what we’re seeing now is young sports bettors are given a gateway because it’s organized It’s getting people also to use the medium of the internet.” There is a high likelihood that fantasy sports players will suffer damage to their emotional or financial health if they become obsessed and cannot stick to time and financial limits According to the Arizona Department of Gaming’s Fantasy Sports revenue report from September-November of 2022 – the heart of last year’s NFL season – revenues took a substantial leap with PrizePicks. Revenue from its in-state entry fees jumped from $846,843,000 to $1,623,414.00 within a month In March, it was found that among selected fantasy sports websites in the United States PrizePicks.com had the longest average time spent on its website per visit by users The simplicity and low cost of licensing have made Underdog and PrizePicks highly prized among sports betting companies who are picking more or less based on player projections and stacking teammates to gain scoring advantages in drafts over competitors Sleeper and Underdog have grown a lot because and because they don’t have to pay the same licensing fees as sports betting companies “They’re going to have to figure out there’s a couple of states that are now kind of trying to shut them down and put them more into the sports betting category.” Due to the ease of roster management and the possibility of utilizing different strategies, best-ball fantasy football, which are large tournaments run by Underdog, has gained popularity in recent years. The Pomeranian But SuperFlex is one of 48 NFL fantasy football tournaments that Underdog offers teams’ starting lineups are determined based on players’ highest scores at the end of the week A snake draft is used to select players by the contestants it’s that people like to bet on sports and people like to gamble – especially on football,” Fawkes said “They’ve been doing it for a long time even though it’s been a rough season for the betting public.” Sports fans playing fantasy sports (daily or season-long) are more engaged fans. It’s what professional leagues, especially the NFL, want since they were early investors in DraftKings and fantasy sports “There’s a lot of research out there that talks about the gaming industry,” Hatfield said And that rapid response is what is triggering more of the issues around gambling behavior accessibility and affordability are some of the three factors that do contribute to gambling problems.” where daily fantasy sports are considered gambling by the laws Advertising restrictions must be enforced for the fantasy sports market to continue to prosper Cody Marmon expects to graduate in December 2023 with his master’s degree in sports journalism Cronkite News is produced by the Walter Cronkite School of Journalism and Mass Communication at Arizona State University Staff members are listed here Learn more about what we do and how to find our content on our broadcast Find out how your news organization can use Cronkite News content Sign up for daily headlines [email protected] Creative Commons Privacy statement In the first excavations of the ancient Roman town of Herculaneum since the 1980s, archaeologists have brought to light the skeleton and personal effects of the so-called “last fugitive” who was killed when Mount Vesuvius erupted in AD79. The recent discoveries were presented to press on 1 December. Around a month into the two-and-a-half year excavations at Herculaneum’s ancient beach, the remains of a man aged between 40 and 45 were found with a heavily blackened skull and bones and with numerous heat-induced fractures. Under the left arm of the skeleton was a cloth shoulder bag inside which an initial analysis has identified various materials: a wooden box containing objects in metal, pieces of cloth and probable traces of gold finish. The evidence suggests the man was on the seashore at the time of death or had been dragged there from the city above by the force of the eruption. Upon impact, he suffered the same fate as the 330 victims whose bodies were discovered sheltering in arched boat sheds on the shore in previous decades. The extremely high temperatures of the pyroclastic flow from Vesuvius caused human tissue to instantly vaporise and the skeleton was imprisoned in a mass of ash, gas and debris. The blackened skeleton of a man aged between 40 and 45 shows numerous heat-induced fractures © Parco Archeologico di Ercolano The skeleton was found with a cloth shoulder bag containing a wooden box and various other materials that will be subject to further analysis in the laboratory © Parco Archeologico di Ercolano The fugitive’s skeleton is the first to have been studied outside the boat sheds using today’s “revolutionised” scientific methods, the Herculaneum archaeological park said in a statement. The excavation project, covering a total area of 1,400 sq. m and funded by the Italian culture ministry and the Packard Humanities Institute, uses water pumps to drain the ancient beach. Ultimately, it aims to reunite the ancient coastline with the famous Villa of the Papyri, opening up public access to the beachfront in 2024. “This is a modern excavation,” says Francesco Sirano, the director of the archaeological park, describing it as “a multidisciplinary open-air laboratory” in which each phase of work is systematically documented. Due to the fragility of the finds, the skeleton and the mass of earth beneath it will now be moved to a laboratory where conservators will continue their analysis, while further discoveries are expected to emerge from the ongoing beach excavations. In recent months, archaeologists have also uncovered many pieces of wood swept on to the shore by the volcanic eruption, including timber beams, door and window frames and panels that may have belonged to the ceilings or roofs of buildings, as well as parts of boats and trees. news29 January 2020Scientists say heat from Mount Vesuvius turned a victim’s brain into glassThe black glassy material was found inside the skull of a 25-year-old caretaker of an imperial building in Herculaneum who was probably asleep at the time of the eruption But some archaeologists argue for conserving what is already uncovered news23 November 2020Pompeii dig unearths incredible preserved remains of two men engulfed in volcanic ashPlaster casts were made of the newly discovered victims of Vesuvius eruption, which are believed to have been a wealthy landowner and his slave “We got on a plane to go to Honolulu. We had engine trouble and turned back,” says Ercolano, who spent six months in the mainland United States preparing to be deployed to Japan. “While we were waiting for the plane to be fixed, the war ended.” Ercolano is one of four surviving World War II veterans at his local VFW po… Subscribe to Narratively to keep reading this post and get 7 days of free access to the full post archives. Photo courtesy Wilson QuarterlyIt\u2019s a bright Sunday afternoon in August 2014 Over wispy gray hair he wears a blue ballcap with the words \u201CU.S Army Air Corps WWII Flyboy\u201D stitched in yellow across the front. With his hat and cane it\u2019s hard to imagine him in the cockpit of a fighter plane The cane doesn\u2019t assist him in nursing an old war wound a pacemaker in his chest and periodic difficulty breathing due to problems with his lungs We had engine trouble and turned back,\u201D says Ercolano \u201CWhile we were waiting for the plane to be fixed Ercolano is one of four surviving World War II veterans at his local VFW po\u2026 the underground route of the Ancient Theater of the Herculaneum Archaeological Park will reopen to the public Visitors will then have the opportunity to fully immerse themselves in the history of the ancient city Bi-weekly appointments for tourists will be organized in groups of twelve on Wednesdays and Saturdays until November 9 with a break in July and August.It will be a journey through time through the eighteenth-century tunnels as part of the enhancement project that includes opening the underground tour route to the public and actions to include the Via Mare neighborhood “The cyclical reopening of the theater,” said Park Director Francesco Sirano “represents for the entire Vesuvian area the possibility of a journey into history from when the theater was accidentally discovered and the investigations that led to the discovery of Herculaneum and Pompeii were started An experience to be recommended to every visitor who is passionate about culture and history with an exciting journey that transports us back through the centuries and makes us protagonists of a discovery that is renewed each time before our astonished eyes But the theater is also located in the heart of the historic center of Herculaneum and can easily become a stop to discover the other beauties and points of interest of the modern city starting with the famous and colorful Pugliano market and the Virtual Archaeological Museum and a few hundred meters away the Villa Campolieto and the Royal Palace of Portici.” Tours will take place on Wednesdays and Saturdays at 9:30 a.m. Tickets can be purchased online at www.ercolano.coopculture.it and directly at the Park’s ticket office For more info: www.ercolano.beniculturali.it Tickets: admission Ancient Theater of Herculaneum 5 euros; integrated admission Archaeological Park of Herculaneum + Ancient Theater of Herculaneum 15 euros; reduced price is provided only for the theater-only ticket of 2 euros for children aged 18-25 The route is underground and reaches about 25 meters from street level.The visit is for adults only.Appointment is at the Archaeological Park ticket office 30 minutes before the start of one’s turn to visit.The pavement is wet in several places and is slippery due to the presence of limestone sedimentations and water it is not suitable for claustrophobic people and people with walking problems or pregnant people those with illnesses that can be influenced by the visiting environment.For safety reasons visitors are asked to carry only small bags.Helmets capes and flashlights will be provided by the Herculaneum Archaeological Park for use on the route.The use of closed The use of hiking shoes is preferred.It is recommended in summer periods to have comfortable sweaters or jackets given the considerable temperature change to be faced during the route In the third week of "Gamblers Delight" on PokerGO's "Poker After Dark," the game was $100/$200 no-limit hold’em with a $200 big blind ante The minimum buy-in for the game was $20,000 In the first week, former Survivor contestant Albert Destrade, Bryan Ercolano and WSOP bracelet winner Trevor Pope made their Poker After Dark debuts, while in the second week someone said “this is going to be a bad call.” Below is a look at five of either the biggest or most interesting hands from this week's episode Jake Daniels raised to $600 from middle position with the 4♥2♥ and Dan Shak called from the button with the K♥Q♥ Destrade defended his big blind with the 6♠5♥ and it was three-way action to the K♣J♥8♥ flop Daniels continued for $1,100 with a flush draw and Shak called with top pair and a superior flush draw Destrade got out of the way and the K♠ appeared on the turn and wasted little time in calling when Shak raised to $7,000 and even before he could count out all the chips Shak called with trip kings Shak claimed the $50,300 pot while Daniels said he was going to buy another $20,000 for his stack Pope raised $600 under the gun with the A♥9♠ and Daniels three-bet to $2,300 next to act with the A♦Q♥ Action folded back to Pope and he called to see a flop of 5♣A♣4♦ Pope check-called a bet of $3,000 and then check-called one of $5,000 on the J♦ turn Pope checked for the third time when the 2♠ completed the board on the river and Daniels bet $8,000 “I feel like I’m slow-rolling you,” Pope said before dropping in a call to create a $29,100 pot “That’s not great,” Daniels said while tabling his hand I had one of those,” Pope admitted before flashing his cards and sending them to the muck Daniels recouped $18,300 and Pope opted to add on $15,000 Ercolano limped from middle position with the Q♦J♦ and Destrade raised to $1,000 from the hijack holding the 6♠6♥ Lynne Ji looked down at the K♦K♣ in the cutoff and three-bet to $3,000 Destrade came along and it was three-way action to a flop of Q♥5♦4♠ Destrade got out of the way and the dealer burned and turned the J♠ He coyly checked and then called when Ji moved all in for $12,500 The two agreed to run the river twice on the $40,500 pot neither the 8♣ on the first run nor 10♥ on the second helped her Ercolano scooped the pot and left Ji to rebuy a pregame segment was shown with Ercolano chatting with sideline reporter Veronica Brill explaining how he met Ji at a home game months earlier After a pair of unsuccessful bluffs left him on a short stack Ercolano limped the cutoff with the A♥9♥ and Ji called from the small blind with the K♣Q♣ Daniels had straddled and exercised his option after looking down at the 6♦6♣ with a raise to $2,000 Two checks saw Ercolano bet $4,000 with top pair The 3♥ turn gave Ercolano an added heart flush draw and he piled for $13,300 Ji hit the tank for a while before giving up on the $27,700 pot Ji would’ve missed had she called and they only ran it once Pope raised to $500 under the gun with the 5♠ and a mystery card Ercolano came along from the small blind with the Q♥6♥ Destrade did the same from the big with the K♣7♦ Two checks saw Pope continue for $1,000 and all three of his opponents called including Ercolano slow-playing trip sixes The 5♥ turn inspired all four players to check and the 5♦ completed the board on the river Pope made a runner-runner fives full of sixes something didn’t add up to him as he found a fold Daniels paused for a few beats and then followed suit by laying down his top two pair Pope asked to see Ercolano’s cards stating he would owe him one meaning Pope would show a future one whenever Ercolano asked Here are how the stacks sat at the end of the episode: Remember, an annual subscription to PokerGO costs $99.99, but you can save $20 off by using promo code “USPO21” at checkout. 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