Is anyone truly surprised that some folks on social media are making a hero out of Luigi Magione
the man accused of gunning down UnitedHealthcare CEO Brian Thompson on a Manhattan street
Members of the media chattering class are wondering what it must say about American society that so many of our fellow citizens are lionizing the alleged murderer as a kind of Robin Hood who stuck it to the man by taking down a leader in the hated for-profit healthcare industry
Some commentators are beginning to sound like the crooked French policeman in “Casablanca” who was “Shocked
Shocked!” to find gambling in a gambling establishment
The hand wringers are late to the party if
they are realizing that social media is very antisocial
even the Boston Marathon bombers and various perpetrators of mass shootings have picked up their share of sympathizers. Cyber America is a place where some people celebrate cops getting shot
while others are quick to insist the victims of excessive police violence deserve what they get
hatred and exultation in the misfortunes of those who are not members of our particular tribe
Social media has provided us a glimpse into the darker recesses of American minds
but that does not mean those dark places were not always there
Some Americans have always celebrated killers
like Bonnie and Clyde, have some dubious claim to be striking a blow for the little guy
The big difference today from days past is that the Internet has given fans of murderers a vastly bigger megaphone
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Tucked away in the picturesque hills of central Italy is Magione – Autodromo dell’Umbria
this small circuit transforms into a vibrant hub for car enthusiasts during the Tarox Magione Super Battle (MSB)
with participation doubling and competitors and spectators travelling from across Italy
I had the honour of being invited by the Magione Super Battle’s organisers
To say it was brilliant would be an understatement
As mentioned in previous MSB coverage on Speedhunters
After visiting the original Attack – formerly known as Battle Evome – Alessio C
was determined to bring a slice of Japanese time attack culture back to Italy
He even secured the blessings of Daisuke Aoki
to use the Attack logo in the event’s promotion
and the Magione Super Battle has grown well beyond its grassroots origins
time attack in this format – particularly centred around Japanese vehicles and culture – is still a relatively new concept
Saturday morning greeted us with patchy weather that slowly gave way to clearing skies
many MSB entrants made their way to Magione for the practice sessions
Autodromo dell’Umbria is a technical circuit similar to Tsukuba
with 11 turns and a 2.5km length (Tsukuba TC2000 has nine turns over 2.0km)
This results in a tight battlefield where competitors aim for times in the low one-minute range
While you might envision Italian car culture dominated by Fiats
there’s a fast-growing Japanese and grassroots Euro car scene
and a handful of Lotus models were all in the lineup
one brand dominated the paddock and wasn’t what I expected: Honda
S2000s and Civics were plentiful at the 2024 Magione Super Battle
showcasing how Hondas have become the go-to chassis for competitors seeking the most competitive and economical way to put down a respectable lap time
Sunday morning brought a stunning fog that blanketed Magione
setting the stage for a perfect day of racing
MSB’s programme included three morning sessions for each category
followed by demo runs featuring notable Italian-built cars
The afternoon showcased the eagerly anticipated ‘Super Lap’ segment
where each car chased class-specific and overall unofficial lap records
but none rivalled the staggering performance of a Honda K-swapped Lotus Exige
which left the rest of the paddock in its rearview mirror with a 1:16:088 lap
I was told that’s faster than a professionally driven Porsche GT3 RS under similar conditions
Talk shows and interviews shared the excitement of time attack experiences
and the pits were kept open for all to explore
The atmosphere echoed that of Attack Tsukuba
fostering a laid-back vibe without any negative competitive rivalry
Both Alessios noted the unprecedented attendance – a testament to the planning and passion invested in the MSB
drawing crowds to the pit wall while they ran their laps
First up was Alby’s astonishing 26B-powered FD3S Mazda RX-7
When I received the invitation to cover the Magione Super Battle
I never imagined encountering a four-rotor in action
This meticulous build is relatively unsuspecting from the outside
but the RX-7 was impossible to ignore as it blasted down Autodromo dell’Umbria’s main straight
Another crowd favourite was a bright yellow Celica
so I’m saving the details for a standalone spotlight
a select group of cars took to the track for MSB’s traditional parade lap
I seized the opportunity to hop into the back of a van
precariously dangling out of the boot to capture the final moments of a fantastic event
I do not doubt that the Magione Super Battle will soon rival Japanese Attack events in size
to the warm hospitality and sense of community
MSB represents the essence of grassroots motorsport passion
it’s only going to get bigger and better from here
More stories from Italy on Speedhunters
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Love this kind of racing event you get to see so many cars coming from different backgrounds and stylesThis is enthusiasts coming together with their passion
and Mazdas at race tracks all over the world: it's called intelligence
Lighting money on fire after you measure it by weight
He who burns the most cash has a massive advantage which is why costs are typically controlled at the club level and even at the professional level in a lot of series
Corvettes are (relatively) CHEAP and parts are readily available
This is why I laugh at all the dorks who complain about LS swaps
because if you have the first thing you learn is that cash is king
THE ONLY PEOPLE WHO BUILD SUPER RARE AND EXOTIC STUFF ARE PEOPLE WHO DON'T RACE AND HAVE EGOS
FOR JOURNALISTS AND CLICKS!!!!Your super crazy twin charged NASA composite rocket ship or whatever abstract build you've made to get 1M followers on instagram is really cool until you're in a foreign country that doesn't have Ferrari V12 cylinder head studs at pep boys
and especially at the amateur level it is about getting seat time over everything
Once you get more experience you will learn a lot of things that surprise you
You can pretty much win any amateur competition with a Honda
Hell you can win a lot of professional events with these 3
Speedhunters is an international collective of photographers
writers and drivers with a shared passion for uncovering the world's most exciting car culture stories
Discussion has spanned a number of subreddits, including one that’s named after the alleged UnitedHealthcare assassin
Skeptics on the channel have broken down each image and pointed out perceived differences between them
That includes the seeming lack of a “unibrow” on the suspect in a snap taken from a Starbucks—the first photo police released last week to include part of the alleged gunman’s face—that was taken just minutes before Mangione is said to have shot 50-year-old Brian Thompson dead on the sidewalk
which Mangione’s mugshot shows was not a complete one
is more visible in other photos taken in New York
That includes the infamous snap of the suspect smiling with his mask down as he checked into a hostel
as well as a photo of him sitting in the back of a taxi
Redditors also noted that the photos released by police showed different colored jackets and backpacks—one grey
the other black—being worn by the suspected killer
“This is an insult to the intelligence of the American people,” one popular post
There may be an explanation for these inconsistencies
as some on Reddit have already pointed out
Police say Mangione spent 10 days in New York City
That’d give the 26-year-old Ivy League grad plenty of time to make a change in clothes before his alleged slaying on Dec
Police also revealed that they found a backpack that belonged to Mangione that was abandoned in Central Park
meaning he could have traveled with two separate bags in New York that’d explain the difference in colors
Driving many conspiracies about Mangione’s arrest—despite police claiming to have a trove of evidence against him
including a manifesto—are people who are skeptical that someone in central Pennsylvania would be able to recognize him with enough confidence to dial up 911
The Reddit user bfhurricane offered a detailed rebuttal to those questioning the photos released by cops
They said that the lack of unibrow was likely due to the quality of the snaps
As to how someone in a western Pennsylvania McDonald’s apparently recognized Mangione
bfhurricane wrote: “In all likelihood...people in Altoona saw the one guy with a mask in rural Western Pennsylvania and it clicked
you’d know they’re the type to be slightly paranoid and suffer from ‘Main Character Syndrome’ and insert themselves into anything that seems out of place
then you’d understand why they’d call the cops over a guy with strong eyebrow game eating suspiciously with his mask on.”
a number of self-proclaimed detectives have their suspicions about Mangione’s arrest
Some have claimed—without evidence—that Mangione was set up by the FBI
Another Reddit comment—with over 1,400 likes—suggests Mangione may merely be a “fall guy” so law enforcement could tout a timely arrest for a crime that’s captured the attention of America
that is not the same person or clothing,” remarked one commenter
how terrifying is the idea that you could be going about your day in your completely mundane existence
and it’s suddenly all turned upside down because the government decided it would be easy to target you for a high profile crime.”
Got a tip? Send it to The Daily Beast here
Subscribe to BuzzFeed Daily NewsletterCaret DownDonald Trump Said People Who "Admire" Luigi Mangione Have A "Sickness," And The Internet Has Many
Many ThoughtsTrump's thoughts have people questioning why he praised Daniel Penny and Kyle Rittenhouse
That’s crazy because I wonder the exact same thing about how people like Trump 🤷🏽♂️
Mr +30 felony’s over here got something to say 😭
As a reminder, Penny is a former Marine who was acquitted of criminally negligent homicide in the 2023 death of subway performer Jordan Neely. At the time, Penny held Neely in a chokehold for about six minutes after Neely — who was unarmed — entered a train car, threw his jacket to the ground, and reportedly said he was hungry and thirsty and wanted to go back to jail
According to some passengers, Neely did not approach anyone on the car. Though, one said he made "lunging movements," NBC reported
a bystander can be heard yelling: “He’s dying..
According to Penny, he reportedly told detectives that he was trying to "de-escalate the situation."
But wasn’t he just at a football game with the White guy that killed that black guy on the subway??
it’s a sickness when the victim is white??
Trump called Rittenhouse a "nice young man."
but he loves himself some kyle rittenhouse… pic.twitter.com/UyDcVqYust
sources sayLuigi Mangione is accused of killing Brian Thompson in Manhattan on Dec
The 26 year old remains locked up in Pennsylvania, challenging his extradition to New York.NEW YORK -- Prosecutors at the Manhattan District Attorney's Office have begun presenting evidence to a grand jury as they work to secure an indictment against Luigi Mangione for the killing of UnitedHealthcare CEO Brian Thompson
The DA's office declined to comment due to the secrecy surrounding grand jury matters
An indictment could strengthen the case for extradition
The 26-year-old Ivy League graduate remains in custody at a Pennsylvania state prison after a judge denied bail on Tuesday
His next court date in Pennsylvania is Dec
"He has constitutional rights and that's what he's doing" in challenging the interstate transfer
defense attorney Thomas Dickey told reporters on Tuesday
on Monday after nearly one week on the run following the Dec
Three shell casings recovered outside the Midtown Manhattan hotel where Thompson was fatally shot match the gun allegedly found on Mangione when he was arrested
Fingerprints recovered from a water bottle and a Kind bar near the crime scene have also been matched to Mangione
Mangione faces charges including allegedly possessing an untraceable ghost gun
he faces charges including second-degree murder
26-year-olfd who was arrested after huge police manhunt appears in shackles in Manhattan courtroom to answer murder and terror charges
News | World
The man accused of fatally shooting the CEO of UnitedHealthcare pleaded not guilty on Monday to murder and terror charges in a state case that will run parallel to his federal prosecution
Luigi Mangione, 26, was shackled and seated in a Manhattan court when he leaned over to a microphone to enter his plea
He was formally charged last week by the Manhattan district attorney with multiple counts of murder
His initial appearance in New York's state's trial court was preempted by federal prosecutors bringing their own charges over the shooting
The federal charges could carry the possibility of the death penalty
while the maximum sentence for the state charges is life in prison without parole
Prosecutors have said the two cases will proceed on parallel tracks
with the state charges expected to go to trial first
Authorities say Mangione gunned down Brian Thompson as he was walking to an investor conference in midtown Manhattan on the morning of December 4
Mangione was arrested in a Pennsylvania McDonald's after a huge five-day police manhunt
carrying a gun that matched the one used in the shooting and a fake ID
He also was carrying a notebook expressing hostility toward the health insurance industry and especially wealthy executives
At a news conference announcing the state charges last Tuesday
Manhattan DA Alvin Bragg said the application of the terrorism law reflected the severity of a "frightening
targeted murder that was intended to cause shock and attention and intimidation."
this was a killing that was intended to evoke terror," he added
has accused federal and state prosecutors of advancing conflicting legal theories
she called their approach "very confusing" and "highly unusual."
Mangione is being held in a Brooklyn federal jail alongside several other high-profile defendants
including Sean "Diddy" Combs and Sam Bankman-Fried
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Mangione was extradited from Pennsylvania on Thursday and quickly rushed to New York City
where he was seen wearing an orange jumpsuit as he was led away from a helicopter by heavily armed police officers and New York City Mayor Eric Adams
Adams said he was hoping to send a message to the suspect: "I wanted to look him in the eye and say you carried out this terroristic act in my city - the city that the people of New York love," the mayor told a local TV station
"I wanted to be there to show the symbolism of that."
An Ivy-league graduate from a prominent Maryland family
Mangione appeared to have cut himself off from family and friends in recent months
He posted frequently in online forums about his struggles with back pain
had worked at the giant UnitedHealth Group for 20 years and became CEO of its insurance arm in 2021
The killing has prompted some to voice their resentment at U.S
with Mangione serving as a stand-in for frustrations over coverage denials and hefty medical bills
It also has sent shockwaves through the corporate world
rattling executives who say they have received a spike in threats
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A live broadcast from Pennsylvaina's State Correctional Institution Huntingdon took an unusual turn Tuesday night as inmates shouted their support for Luigi Mangione, the suspect in the fatal shooting of UnitedHealthcare CEO Brian Thompson
Luigi Mangione's fellow prisoners yelled "Luigi's conditions suck" and "Free Luigi" from their cells in Pennsylvania during an interview:pic.twitter.com/znmGtimxcS
The novel interview format came about on NewsNation's program Banfield
as inmates called out from their cells and turned lights on and off in response to the live broadcast
They also shouted complaints about prison conditions and demanded Mangione's release
Free Luigi," they yelled to reporter Alex Caprariello
is currently housed in a single occupant cell and does not have access to a television
Mangione faces the possibility of being extradited to New York
where he is accused of using a "ghost gun" to fatally shoot Thompson near a Midtown Manhattan hotel on December 4
Authorities say Mangione's fingerprints match those found on a water bottle near the crime scene, BBC reported
and a 262-word manifesto detailing his motivations
The gun he had on him matches shell casings from the crime scene
Mangione's extradition remains delayed as Pennsylvania pursues a governor's warrant, a process that could take up to 30 days. Meanwhile, Mangione continues to fight extradition, calling the charges against him "completely unjust."
FC Cincinnati 2’s Peter Magione has been impressive in his first professional season
from playing as a striker up top to now being used as a number ten
His journey from Maryland to Penn State is one for the record books
Magione attended Dulaney High School in Timonium
and he grew up playing for Baltimore Celtic in the U.S
He also played club soccer for Baltimore Armour for three seasons
two national league titles and one national championship in his club career with the Armour
He also spent one season with Orlando City in the U.S
helping the team win a USDA conference championship title in the 2018-19 season
Mangione signed to play collegiate soccer at Penn State in the Big Ten Conference
During his freshman season with the Nittany Lions
Magione scored six goals and recorded six assists
playing in 11 games and starting 10 as a center-forward
he was named to the Big Ten All-Freshman Team
he started all but one match for Penn State
Magione also served as vice-captain for the team in just his second season
He registered a hat trick against Villanova
which was the first hat trick by a Nittany Lion since 2010
He also earned All-Big Ten First Team and Big Ten All-Tournament Team
During Magione’s junior season with Penn State
he started all 16 games scored eight goals
He was also named to the All-Big Ten First Team for the second straight season
Magione also received national recognition as he was named to the Herman Trophy Watch List
Magione was awarded the Big Ten Offensive Player of the Year for the second time in his collegiate career
He played 19 games and scored 10 goals on the year
Magione played a total of 1,627 minutes and ranked third in the nation in game-winning goals
Magione appeared in 67 games for Penn State
He is ranked 13th all-time in program history in goals scored
he has started every game for FCC 2 and has two goals and two assists in his debut season
A young versatile forward with a lot of potential
Magione should have a bright future with FC Cincinnati 2
with hopes of making an impact for the first team in the future
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Luigi Mangione has now been charged with the murder of UnitedHealthcare CEO Brian Thompson
Update: Following his arrest earlier today
the suspect in the fatal shooting of UnitedHealthcare CEO Brian Thompson
The 26-year-old will face charges in New York
indicates that he also worked as a programming intern at Firaxis Games for one year and four months beginning in 2016
helping to fix hundreds of bugs in Civilization 6
a representative of Firaxis parent company 2K Games wrote via email
Mangione said he taught himself how to code in high school
which is what led him into computer science at the college level
and eventually to launching the school's game dev organization: "I just really wanted to make games."
'I don’t code; can I be part of game development
please — we have a lot of programmers
and need people who aren’t'," Mangione said at the time
"It’s cool because if you think about game development
all from different majors and parts of the school who can be interested."
Keep up to date with the most important stories and the best deals
A little-used Twitter account under Mangione's name, registered in 2016, doesn't include any mention of Civilization 6 or gaming in general, other than featuring an image of the Pokémon Breloom in the banner
A Steam profile named "Pep" with the word "(Luigi)" as the description and matching avatar seemingly belonging to Mangione is visible to the public on Steam
The user is admin of a small Steam group for the game development club that Mangione belonged to at the University of Pennsylvania
and a member of a four-member group called UPenn L4D2 Squad
has 2,947 total hours on record according to SteamDB's Steam Calculator
when Magione would have been approximately 15 years old
The gameplay history is consistent with someone who is an avid gamer and game developer
featuring playtime with many prominent independent games and other popular games of the last decade:
a fake New Jersey ID—also believed to be used by the killer when he checked into a hostel prior to the shooting—and a three-page manifesto that indicates "some ill will toward corporate America."
A few hours after his arrest, a video promising "the truth" was posted to a YouTube channel attributed to Mangione
It's not confirmed whether the channel is actually his
but the account associated with the channel was created in January 2024
the channel and its associated videos—a second "part 2" video was set to go live at 6:45 pm ET—were deleted
Copyright 2025 The Associated Press. All Rights Reserved.
Police in Pennsylvania arrested a “strong person of interest” Monday in the brazen Manhattan killing of UnitedHealthcare’s CEO. Police identified the suspect as 26-year-old Luigi Mangione.
NYPD dogs and divers returned to New York’s Central Park today while the dragnet for Thompson’s killer stretched into a sixth day. The search went on as news broke that a man with a gun thought to be similar to the one used in the killing of UnitedHealthcare CEO Brian Thompson was taken into police custody for questioning in Pennsylvania. (AP video: David Martin/Cedar Attanasio)
New York City’s police commissioner says police have arrested a man with a weapon “consistent with” the gun used in the killing of UnitedHealthcare CEO Brian Thompson. Thompson died in an ambush Wednesday outside a Manhattan hotel.
Gov. Josh Shapiro, center, speaks during a press conference regarding the arrest of suspect Luigi Mangione, Monday, Dec. 9, 2024, in Hollidaysburg, Pa., in the fatal shooting of UnitedHealthcare CEO Brian Thompson. (AP Photo/Ted Shaffrey)
This booking photo released Monday, Dec. 9, 2024, by the Pennsylvania Department of Corrections shows Luigi Mangione, a suspect in the fatal shooting of UnitedHealthcare CEO Brian Thompson. (Pennsylvania Department of Corrections via AP)
New York Police Deputy Commissioner Kaz Daughtry arrives at Altoona Police Department, where a man with a gun thought to be similar to the one used in the killing of UnitedHealthcare CEO Brian Thompson has been taken into police custody for questioning, Monday, Dec. 9, 2024, in Altoona, Pa. (AP Photo/Gene J. Puskar)
NYPD officers in diving suits search a lake in Central Park, Monday, Dec. 9, 2024, in New York. (AP Photo/Yuki Iwamura)
New York Police officers arrive at Altoona Police Department, where a man with a gun thought to be similar to the one used in the killing of UnitedHealthcare CEO Brian Thompson has been taken into police custody for questioning, Monday, Dec. 9, 2024, in Altoona, Pa. (AP Photo/Gene J. Puskar)
Altoona Police officer Tyler Frye, center, speaks during a press conference regarding the arrest of suspect Luigi Mangione, Monday, Dec. 9, 2024, in Hollidaysburg, Pa., in the fatal shooting of UnitedHealthcare CEO Brian Thompson. (AP Photo/Ted Shaffrey)
McDonald’s restaurant, where an employee alerted authorities to a customer who was found with a weapon and writings linking him to the the brazen Manhattan killing of UnitedHealthcare’s CEO, Monday, Dec. 9, 2024, in Altoona, Pa. (AP Photo/Gene J. Puskar)
Deputy Commissioner of Operations Kaz Daughtry speaks during a press conference regarding the arrest of suspect Luigi Mangione, Monday, Dec. 9, 2024, in Hollidaysburg, Pa., in the fatal shooting of UnitedHealthcare CEO Brian Thompson. (AP Photo/Ted Shaffrey)
NYPD officers and K-9 dog search around a lake in Central Park, Monday, Dec. 9, 2024, in New York. (AP Photo/Yuki Iwamura)
An NYPD police officer and K-9 dog search around a lake in Central Park, Monday, Dec. 9, 2024, in New York. (AP Photo/Yuki Iwamura)
In this photo taken from video, New York Police chief of detectives Joseph Kenny answers questions during a news conference, Monday, Dec. 9, 2024, in New York. (New York City Mayor’s Office via AP)
A poster issued by the Federal Bureau of Investigation shows a wanted unknown suspect. (FBI via AP)
NYPD officers in diving suits sit after searching the lake in the Central Park, Monday, Dec. 9, 2024, in New York. (AP Photo/Yuki Iwamura)
The Altoona Police Department is seen where suspect in the UnitedHealthcare CEO shooting, 26-year old Luigi Mangione is being held Monday, Dec. 9, 2024, Altoona, Pa. (Benjamin B. Braun/Pittsburgh Post-Gazette via AP)
The chance sighting at the restaurant in Altoona led to a dramatic break in a challenging but fast-moving investigation that captivated the public in the five days since the shooting that shook the business world.
Late Monday, Manhattan prosecutors filed murder and other charges against Mangione, according to an online court docket. He remained jailed in Pennsylvania, where he was charged with possession of an unlicensed firearm, forgery and providing false identification to police.
Mangione was sitting in the rear of the McDonald’s wearing a blue medical mask and looking at a laptop computer, court documents said. A customer saw him and an employee called 911, said Kaz Daughtry, an NYPD deputy commissioner.
Altoona Police Officer Tyler Frye said he and his partner recognized the suspect immediately when he pulled down his mask. “We just didn’t think twice about it. We knew that was our guy,” he said.
AP correspondent Jennifer King reports that the suspect under arrest for the killing of UnitedHealthcare’s CEO faces charges in New York.
When one of the officers asked if he’d been to New York recently, he “became quiet and started to shake,” according to a criminal complaint based on their accounts of the arrest.
He was taken into custody at about 9:15 a.m., police said.
Mangione had clothing and a mask similar to those worn by the shooter and a fraudulent New Jersey ID matching one the suspect used to check into a New York City hostel before the shooting, NYPD Commissioner Jessica Tisch said.
NYPD Chief of Detectives Joseph Kenny said Mangione was born and raised in Maryland, has ties to San Francisco and a last known address in Honolulu.
“Our family is shocked and devastated by Luigi’s arrest,” Mangione’s family said in a statement posted on social media late Monday by his cousin, Maryland lawmaker Nino Mangione. “We offer our prayers to the family of Brian Thompson and we ask people to pray for all involved.”
Mangione was arraigned and ordered held without bail during a brief court hearing. Asked if he needed a public defender, he asked if he could “answer that at a future date.” He eventually will be extradited to New York to face charges in connection with Thompson’s death, Kenny said.
Police found a three-page document with writings suggesting that Mangione had “ill will toward corporate America,” Kenny said.
The handwritten document “speaks to both his motivation and mindset,” Tisch said.
A law enforcement official who wasn’t authorized to discuss the investigation publicly and spoke with The Associated Press on condition of anonymity said the document included a line in which Mangione claimed to have acted alone.
“To the Feds, I’ll keep this short, because I do respect what you do for our country. To save you a lengthy investigation, I state plainly that I wasn’t working with anyone,” the document said, according to the official.
It also had a line that said, “I do apologize for any strife or traumas but it had to be done. Frankly, these parasites simply had it coming.”
Mangione also had a passport and $10,000 in cash — $2,000 of it in foreign currency, authorities said. Mangione, who said Hawaii was his most recent address, disputed the amount.
Thompson, 50, was killed last Wednesday as he walked alone to a hotel, where UnitedHealthcare’s parent company, UnitedHealth Group, was holding its annual investor conference, police said.
UnitedHealth Group thanked law enforcement in a statement. “Our hope is that today’s apprehension brings some relief to Brian’s family, friends, colleagues and the many others affected by this unspeakable tragedy,” a company spokesperson said.
Mangione attended an elite Baltimore prep school, graduating as valedictorian in 2016, according to the school’s website. He went on to earn undergraduate and graduate degrees in computer science in 2020 from the University of Pennsylvania, a school spokesperson said.
One of his cousins is a Maryland state legislator and his family bought a country club north of Baltimore in the 1980s. On Monday, police blocked off an entrance to the property, which public records link to the suspect’s parents. A swarm of reporters and photographers gathered outside.
Mangione went from Philadelphia to Pittsburgh after the shooting, and likely “was in a variety of locations across the state,” said Lt. Col. George Bivens of the Pennsylvania State Police said.
“Based on everything we have seen, he was very careful with trying to stay low profile, avoid cameras — not all that successfully in some cases, but that was certainly the effort he was making,” Bivens said.
In the days since the shooting, police turned to the public for help by releasing a collection of nine photos and video — including footage of the attack, as well as images of the suspect at a Starbucks beforehand.
Photos taken in the lobby of a hostel on Manhattan’s Upper West Side showed the suspect grinning after removing his mask, police said.
On Monday, police credited news outlets for disseminating the images and the tipster for recognizing the suspect and calling authorities.
Sisak and Attanasio reported from New York. Associated Press writers Michael Rubinkam and Maryclaire Dale in Pennsylvania; Lea Skene, in Baltimore; and John Seewer in Toledo, Ohio, contributed to this report.
The comedian recently appeared on PIX11 News in which he spoke about having a rough holiday this year
“I was supposed to spend them with my cousin
we’re proud of you Luigi,” added Soresi — leaving the news anchors floored
After everyone nervously chuckled about the shocking joke
come to the show and let’s just celebrate this year
Mangione won’t be able to make it to that news platform this year — or any other one for the foreseeable future if he’s found guilty of murder in the shooting death of UnitedHealthcare CEO Briain Thompson
The lead suspect in the case has pleaded not guilty to charges in connection with the shooting
While being arranged in a New York courtroom recently
supporters stood outside of the building while carrying signs that read “deny
videos of the arraignment show people chatting “Free Luigi!”
recently announced that Magione has been charged with the following: one count of first-degree murder in furtherance of terrorism
two counts of second-degree murder (with one also linked to alleged terrorism)
two counts of second-degree criminal possession of a weapon
four counts of third-degree criminal possession of a weapon
one count of fourth-degree criminal possession of a weapon
and one count of second-degree criminal possession of a forged instrument
Mangione didn’t have any family members present
Though Mangione has pleaded not guilty to the state charges for the shooting, his mother reportedly told authorities that she could “see him” doing it.
Luigi Mangione and Diddy Are in the Same Prison
McDonald's Worker Who ID'd Luigi Mangione Might Not Get $60,000 Reward
Several Altoona McDonald’s Hit With Bad Reviews After Mangione Arrest
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If you're scratching your head at the headline above
To recap: Suspected UnitedHealthcare CEO killer Luigi Mangione was arrested in Altoona, Pennsylvania while at a McDonald's
an alleged viral tweet from Burger King's started making the rounds: "We don't snitch."
that would be a response to the arrest at McDonald's IF IT WAS REAL
There's even a community note on X (formerly Twitter) that said this: "Burger King did not post this
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We left off last year with hope that the Magione Superbattle would become an annual event
attracting time attack enthusiasts from all over Italy and Europe
Two full days of track action with all the excitement that only Japanese time attack events can provide
For those who missed last year’s event recap on Speedhunters
The idea for this event started many years ago during a trip to Japan – specifically
a day out at Tsukuba Circuit for the now defunct Battle Evome
The atmosphere at Tsukuba was unlike anything we had ever experienced before
and the iconic location itself was all amazing and not something you could ever forget
Anyone who has attended a major time attack event in Japan will surely understand what we are talking about
Our idea was to bring a similar event to Italy
and the choice of circuit fell on Autodromo dell’Umbria
Umberto Mario Borzacchini – better known as Magione Racetrack
this circuit is far away from the iconic Italian tracks
but its layout and length (2.50km/1.55mi) is very similar to Tsukuba TC2000
The first Magione Superbattle event last year was contested over the course of a single day
but this year we decided to step things up
with free practice day on Saturday and the Superbattle on Sunday
The upside of this was more track time for those who travelled from afar (we had competitors from Portugal and Cyprus as an example)
We doubled the attendance and brought an extreme variety of cars to the track
we also introduced a kei-style car class – inevitably Europeanized for minicars – to give more people an opportunity to compete in the Superbattle
It didn’t take long on Saturday for some respectable times lap times to be laid down
something helped by the low ambient temperature and drying asphalt
The lap times set on the practice day didn’t count for Sunday’s Superbattle
but were included in the circuit’s lap time ranking list
which has been kept current since 2017 when the track was resurfaced
The 50 fastest lap ranking follows the one Option magazine keeps for Tsukuba Circuit
The drivers had to fight the rain and cold
but that just pushed them to set the very best times they could in the wet
lap times were five seconds slower than in the dry
which I think highlights the skill of the drivers
especially those whose cars don’t have ABS or electronic driving aids
we will do everything possible to keep this dream alive
returning annually to the track we like to call the ‘Italian Tsukuba’
racing for pure fun or to represent a workshop
come together and enjoy time attack racing in between a pasta dish and an arrosticino (skewered grilled meat) or two
We’re dedicated to making the Magione Superbattle the reference time attack event in Italy
who also want to see the Superbattle succeed
IAMTHESPEEDHUNTER related stories on Speedhunters
Very good coverage and photos of the Superbattle
Love to see more exciting car articles from you guys soon
An investigation is taking place after a 29-year-old sadly died following an on track accident in Italy
Magione circuit One week after a racer lost his life at the Manx GP
another motorcyclist has passed away after an accident in Italy
29-year-old Nicola Cardinali was taking part in a track day at Magione on Monday aboard a Yamaha R1
The accident took place during the afternoon as Cardinali suddenly lost control and crashed into the barriers
The impact of the accident immediately appeared to be serious
and Cardinali was attended to by a circuit’s medical team
Cardinali was quickly transferred to a hospital in Perguia
the Italian rider died during the transfer despite attempts to revive him from the medical team
the track’s cameras and Cardinali’s motorcycle were recovered and an investigation into what happened is underway
The Magione racetrack and the municipality of Marciano expressed their closeness and condolences to the family
and confirmed a day of mourning on the day of the funeral
We at Visordown express our condolences to the family and friends of Nicola Cardinali
The Autodromo dell’Umbria is a short 1.5 mile circuit which has staged several feeder-series races in the past
mainly four-wheel racing rather than two wheels
But it is also used as a testing track and track day venue for both drivers and riders
The most famous driver to hold a record around the Italian circuit is Aston Martin F1 driver Lance Stroll
The circuit was created in 1970 by a group of friends and it featured in the video game Assetto Corsa
hosting motorcycle races and the Italian Formula 3 championship
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Next Pierer Mobility Preliminary Sales Report Reveals Extent of Losses Robert JonesNews editorAfter graduating with a sports journalism degree
Robert joined Crash.net to lead the WorldSBK coverage in 2021
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Autodromo dell’Umbria – better known as Magione Racetrack – is a small circuit located in Central Italy
green region of Umbria it’s far away from the iconic Italian tracks
but the layout and length (2.50km/1.55mi) is very similar to Tsukuba Circuit
Central Italy isn’t really famous for time attack though
it’s not easy to find large numbers of hardcore enthusiasts
The most popular motorsports in this region are slaloms and uphills
However, this did not stop me and my friends Riccardo (Mocini) and Stefano (Trapè) from putting on this time attack event in November last year. We named it the Magione Superbattle
It all started many years ago during a trip to Japan – specifically
a day out at Tsukuba Circuit for a Battle Evome time attack event
The atmosphere at the event wasn’t like anything I had ever experienced before
the quality of the cars and the iconic location itself – it was all amazing and not something I’ll ever forget it
Anyone who has attended a major time attack event in Japan will surely understand what I’m talking about
We wanted the Magione Superbattle to be unique and
we need to give special thanks to one of the most important people in time attack – Daisuke Aoki
Daisuke-san gave us a big hand with the classes and rules in general
he gave us the true Attack spirit and supported us by allowing use of the Attack logo
but these were split into a number of classes dependant on chassis and engine configuration – FWD Naturally Aspirated
We also added an Open class for supercars and anything that didn’t fall into one of the main categories
we allowed visitors to park their cars inside the paddock which created a real community atmosphere
something we’ve all missed over the past few years
There was a lot of variety in the competition entries
being in Italy there were just as many European models
Tires were capped at semi-slicks with no limit on size
and the same went for aero – anything was eligible
We decided to keep this aspect free to attract as many cars as possible
The best time of the day was a 1.17.423 lap from a lightly-tuned Ferrari 488GTB
and this set the benchmark for future Magione Superbattle events
It goes to show how good these cars are straight from Maranello
While there is no official lap record for a road car at Magione Circuit
those of us who have been living at this racetrack for many years know that this is a great time
Hopefully we’ll get to see it challenged in years to come though
Our dream is for the Magione Superbattle to become an annual event
attracting time attack enthusiasts from all over Italy and beyond
More IAMTHESPEEDHUNTER Posts
Suprised by the number of JDM and lack of European cars in the beginning
then later on in the article they did appear but the last thing i could image is a Smart with a Marlboro livery and a tribute to Senna.Good luck in the upcoming years
hope you get a global attention like other time attack events
Shows how much of the global car scene is posing metoos when such a clean
well intentioned event like this isn't held every weekend of every week all over the world
but why the same handfuls at the track?"In the mouth of the wolf" to these guys
how the hell has no one mentioned that the GR "Corolla" is 9001% more Honda than the actual "Civic type R" is
Honda pretends it didn't just make a super cheapened copy of the Urus
but when Toyota can deliver the real deal for them
how can sheeple be that blind and continue to buy any type R's
Probably the reason there's no expensive BMW/Audi/etc at this/any legit grassroots event: poseurs are poseurs because they don't get it
graduate from wannabes to honest with themselves (you're not fooling us
and grow into actual enthusiasts that aren't responsible for killing sports cars
don't ruin the chance to get the best ICE production cars ever with your BS
and fake ideas of what speed is (hint: it's not "stage 88 tunes" or how much money you threw at a mechanic/dealership)
...the GR "Corolla" is 9001% more Honda than the actual "Civic type R" is
I didn't know Honda made AWD Civic Type-Rs
GR Yaris is a WRC homologation special like Evos and Imprezas
so it is never meant to compete with Civic Type-Rs.The only thing I can agree on is when people keep harping that the new GR Supra "iS a BmW"
In a world where sports cars are being slowly replaced with crossovers that tries to be sports cars
we have people who just aren't grateful for the existence of it
Let these people enjoy their hobbies however they please
Bruh ikr that's like someone saying the Mustang is more "Camaro" than the Camaro or the Corvette being more "Ferrari" than Ferrari like what
And for someone who just does nothing but criticize and bring down people all day that just shows the kind person he is
if italy had texas or florida laws regarding cars this would be a lot more popular
It's a shame the country with so much auto history is so strict
Somehow they manage to put on a Grand Prix
there's no way to draw any real conclusions as to why it had to be structured as it was
But Italy's hardly lacking for automotive events
Somehow I always overlook Italy especially for track events but man seeing something like Time Attack in Italy is a cool sight to seeAnd I love the diversity of cars on the track which just makes the experience even better
"in boca al luppo ragazi" I hope more of this kind of event's can grow and spread across all the south Europe
Good look and i am already wait for see the next event
I want to know more about that Smart fortwo
Looks like a hoot to push around the track
It's not my first publication on Speedhunters but the feeling is the same
goosebumps for 20 minutes in a row and tears in the eye
Just want to say thanks to all the organizers of the Magione Superbattle for having me as photographer and for believe in me since 2018
A super thanks to all the people that partecipated at the event and make a dream of 4 Italian enthusiast came true
hope everyone are liked the pics and the words in the article wrote by Alessio
You will see more of my works on Speedhunters this year
Does anyone know what front bumper is on that eclipse in the front
we've been very close several times (Lago Trasimeno
Perguia) so I'll have to check the schedule next time we're there
Visitors walk through a living history museum in Plymouth
Communities around the globe honor the fall harvest season with fun celebrations—Here are the best destinations to plan a trip
and fish with the Massasoit and Wampanoag Native American tribes
Abraham Lincoln declared Thanksgiving a national holiday in 1863
On the final Sunday of February, the Archbishop of Mendoza sprinkles the season’s first grapes with holy water and offers the new vintage to God, setting off a month of celebrations in Argentina’s Mendoza region
Crowds line the streets to watch a parade of competing beauty queens atop their regional floats
and the festival culminates with a spectacular show at the amphitheater—musicians
and dancers take to the stage before a Harvest Queen is chosen amid a backdrop of spectacular fireworks
Dewi Sri, the rice goddess, is venerated as a matter of course in Bali
and simple bamboo temples dedicated to the goddess are erected in the upstream
Small dolls of rice stalks representing Dewi Sri are placed in granaries as offerings
Chanthaburi, Thailand
is known for gemstones—and for its profusion of beautiful native fruits
the annual Fruit Fair exhibits exotic durians
and mangosteens in vibrant arrangements as elaborate as Buddhist mandalas
There are produce competitions and art displays
and the opening-day parade features floats made from thousands of tropical fruits and vegetables
Sukkot celebrates Israel’s bountiful harvests and recalls the time when the Israelites wandered the desert living in temporary shelters
are shaken every day in all directions to honor the gifts from the land
At Epiphany, which recalls the visit of the three Wise Men to the infant Jesus, processions in Greece set off from local churches to the ocean
where a priest blesses a gold cross before hurling it into the waves
Men leap in to be first to retrieve it; the victor achieves grace
and banishes old spirits from the new year
In Italy
Magione’s two-day festival in November celebrates both the feast day of St
bringing together everyone involved in the production of olive oil
A priest blesses the new oil at a special Mass
and the town hosts a lavish medieval dinner at its 12th-century castle
Lammas marks the beginning of the harvest season, when food is abundant and the light begins to wane. Early Britons baked bread from the new crop to leave on church altars
and corn dolls decorated bounteous feast tables
Funchal’s April flower festival fills the air with fragrance and marks the arrival of spring in Portugal
Each of the island’s children brings a bloom to create the colorful Muro da Esperança (Wall of Hope)
and intricate flower carpets line the streets
In late December, Swiss men journey to the sea to gather water so Incwala can begin. Branches from the sacred lusekwane tree are woven into a bower for the king, and only when he eats the first fruit can his people partake of the harvest.
The Onion Market is Weymar's oldest and largest folk fair
Metrics details
Alterations to cell polarization or to intercellular junctions are often associated with epithelial cancer progression
We show here that the loss of the junctional scaffold protein MAGI1 is associated with bad prognosis in luminal BCa
E-cadherin and the actin binding scaffold AMOTL2 accumulate in MAGI1 deficient cells which are subjected to increased stiffness
These alterations are associated with low YAP activity
but with an elevated ROCK and p38 Stress Activated Protein Kinase activities
suggesting that MAGI1 limits p38 activity in part through releasing actin strength
the increased tumorigenicity of MAGI1 deficient cells is rescued in the absence of AMOTL2 or after inhibition of p38
demonstrating that MAGI1 acts as a tumor-suppressor in luminal BCa by inhibiting an AMOTL2/p38 stress pathway
partly overlapping with previous classifications (such as ER/PR/HER2 receptors expression status)
overlapping strongly with triple-negative breast cancers
are the most aggressive and present the worst prognosis
even though luminal A and B subtypes (typically ER/PR positives) usually respond well to current treatments
they become very difficult to treat with very poor outcome
Thus it appeared that the apical junction-localized MAGI1 scaffold protein participates in multiple complexes to fine-tune adhesion and signaling
and may therefore be considered as a tumor suppressor
We report here that low levels of MAGI1 are associated with bad prognosis in luminal ER + BCa
Impairing MAGI1 expression in luminal BCa cells promoted their growth in 2D
and their ability to grow in low attachment conditions in-vitro and in subcutaneously grafted nude mice
We further document that MAGI1 deficient cells accumulate specific junctional proteins
we show that all MAGI1 deficient phenotypes are suppressed by down-regulating AMOTL2 suggesting that AMOTL2 and its effects on junctions is the primary cause of the increased tumorigenicity after MAGI1 loss
we could further show that MAGI1 deficient luminal BCa cells experience higher stiffness as evidenced by increased Young’s modulus
and ROCK activity as evidenced by increased ROCK-specific Ser19 phosphorylation of the regulatory Myosin Light Chain 2
They activate the p38 stress signaling pathway while YAP activity is antagonized
we provide evidence that releasing actin cytoskeletal strength
or impairing p38 activity can revert the effects of MAGI1 loss
elevated AMOTL2/E-cadherin and junction dysfunction
together with actin cytoskeletal tension activate the p38 stress pathway fueling tumorigenicity
indicated that low MAGI1 expression levels were associated with worse prognosis in relapse-free survival for BCa patients
but only in ER+ (mainly luminal) molecular BCa subtypes (Kaplan Meier curve; Supplementary Fig
We thus decided to investigate the functional role of MAGI1 and the consequence of MAGI1 knockdown in luminal BCa
and generated MCF7 and T47D cell lines in which MAGI1 was targeted by constitutive shRNA
Two independent shRNA constructs targeting different parts of the MAGI1 transcript were used
which led respectively to more than 90% and around 60% MAGI1 knockdown at the protein level as shown by western blot and immunofluorescence analyses (Supplementary Fig
The knockdown was specific for MAGI1 and did not induce compensatory up-regulation of MAGI2 and MAGI3
the two remaining MAGI family members (Supplementary Fig
shMAGI1(3-1) was the most potent resulting in almost knock-out like down-regulation
and was therefore used in all subsequent studies and referred to as shMAGI1 thereafter
It should be noted that in the subsequent analyses of MAGI1 function similar effects were obtained using the independent shMAGI1(1-1) ruling out non-specific phenotypes of the shMAGI1(3-1) (Supplementary Fig
MAGI1 impairment induces tumorigenic phenotypes in epithelial cells
(A) MTT assay (OD 560 nm) representing 2D cell growth of MCF7shMAGI1 as compared to MCF7shLuc cells
Bars represent mean ± Standard Deviation (SD; n = 10 wells as replicates) of a representative experiment (out of 3)
Unpaired two-tailed Student's t-test; **p < 0.01; ***p < 0.001
(B) Cell cycle phases of MCF7shLuc and MCF7shMAGI1 cells assessed after BrdU incorporation and analyzed by flow cytometry
showing an increased proportion of cells in S phase at the expense of G0/G1 after MAGI1 invalidation
The pie chart also showed no major difference in the percentage of apoptotic cells in SubG1 phase (around 2% in shLuc and 1% in shMAGI1 cells)
(C) Left: quantification of colony numbers of MCF7shMAGI1 cells grown in anchorage independent conditions (soft agar assay) and represented as fold increase compared to MCF7shLuc cells
Data are presented as the means ± SD (n = 3)
Unpaired two-tailed Student's t-test; ***p < 0.001
Right: western blot analysis of whole protein extracts issued from the cells used in the soft agar assays and showing the relative amounts of MAGI1 in the different cell lines; Tubulin was used as a loading control
Uncropped blots can be found in the Supplementary Information
(D) Top: quantification of mammospheres represented as total area issued from MCF7shMAGI1 cells and shown as fold increase compared to MCF7shLuc cells
Data are presented as the means ± SD (n = 4)
Bottom: images of mammosphere formation assay showing a representative experiment
The loss of MAGI1 in primary tumors induces tumor cell proliferation
(A) Primary tumor growth of MCF7shLuc and MCF7shMAGI1 cells injected subcutaneously in nude mice
Primary tumor growth was assessed by measuring the tumor volume over time until the tumors were too big and the mice had to be euthanized
Bars correspond to the mean ± Standard Error to the Mean (SEM; n = 8 mice per group)
Unpaired two-tailed Student’s t-test; *p < 0.05
(B,C) Representative immunohistochemical staining of Ki67 in primary tumors obtained after subcutaneous engraftment of either MCF7shLuc (B) or MCF7shMAG1 cells (C)
Brown staining indicates positive immunoreactivity
the red * highlights an increased number of mitotic cells in the MCF7shMAGI1-derived primary tumor
(D,E) Quantification of the immunohistochemical analysis in (B,C)
showing the percentage of primary tumor cells stained positively for Ki67 (D) and the normalized mean intensity of Ki67 positive cells (E) in MCF7shMAGI1 and MCF7shLuc primary tumors
Bars correspond to the mean ± SD (n = 4 for shLuc and n = 5 for shMAGI1)
Unpaired two-tailed Student’s t-test; **p < 0.01 and ***p < 0.001
The loss of MAGI1 affects E-cadherin levels and localization in MCF7 cells
(A) Representative immunofluorescence experiments performed in MCF7 cells monitoring MAGI1 localization (red) compared to E-cadherin
DAPI (blue) was used to stain DNA and the nuclei
(B) Western blot analysis of whole protein extracts (n = 4) monitoring the expression the junctional components Claudin-1
E-cadherin and AMOTL2 in MCF7shMAGI1 cell lines compared to MCF7shLuc
Western blot experiments have been repeated at least four times
Protein expression levels were quantified as compared to Tubulin
(C) Representative immunofluorescence experiments (n = 3) were performed on MCF7shMAGI1 compared to MCF7shLuc cells monitoring the localization of β-catenin
Note the slight sub-cortical accumulation of E-cadherin shown in the high magnification images
(D) Representative E-cadherin staining (green) of MCF7shLuc and MCF7shMAGI1 shown through the Z axis
The loss of MAGI1 affects MCF7 cell compaction
(A) Representative phase contrast and fluorescence images of MCF7shLuc and MCF7shMAGI1 cells grown in 3D spheroid cultures and stained with E-cadherin (red) and DAPI (blue)
(B) Calculated perimeters for 3D spheroid cultures of MCF7shMAGI1 normalized by the perimeter of MCF7shLuc cells
Bars represent mean ± SD (n = 10 spheroids) of five independent experiments
(C) Calculated circularity for 3D spheroid cultures of MCF7shLuc and MCF7shMAGI1 (calculations were done with the ImageJ software where a value of 1 is considered as a perfect circle)
(D) MTT assay (OD 560 nm) representing 3D spheroid cell growth of MCF7shMAGI1 compared to MCF7shLuc cells 5 days after cell seeding
(E) Elastic Young’s modulus (EYM) of cells: Hertz contact mechanics model for spherical indenters was used
the apical surface EYM is significantly elevated when compared to control MCF7shLuc cells
Data are represented as mean + /− SD: MCF7shLuc EYM = 258.8 + /− 101
Unpaired two-tailed Student’s t-test; *p < 0.05 (n = 132 and 94 for MCF7shLuc and MCF7shMAGI1 respectively)
(F) Western blot analysis on whole protein extracts (n = 3) of ROCK-specific ser19 phosphorylation of Myosin Light Chain 2
total MLC2 and MAGI1 in MCF7shMAGI1 cell lines compared to MCF7shLuc
(G) Quantification of the representative Western blot showing protein expression represented in panel E
Phosphorylated proteins were quantified as compared to their total protein counterparts to evaluate their activation
We thus explored whether these two pathways could be affected following MAGI1 depletion
The loss of MAGI1 tumorigenic phenotypes are not associated with active YAP
(A) Western blot analysis on whole protein extracts (n = 3) of phosphorylated YAP (S397 and S127)
total β-catenin and MAGI1 in MCF7shMAGI1 cell lines compared to MCF7shLuc
(B) Representative immunofluorescence images (n = 3) of endogenous MAGI1 and YAP protein expression in MCF7shLuc and MCF7shMAGI1 cells cultured to similar confluence (60.4% and 63.2% respectively)
(C) Quantification of MAGI1 and YAP staining in a tissue micro-array (TMA) from luminal breast cancer patients in a cohort of 28 patients
showing the strong correlation between MAGI1 membranous and YAP nuclear localizations; Fisher exact test
Histogram shows the percentages of patients having a nuclear or a cytoplasmic YAP staining according to the absence or the presence of MAGI1 membranous staining
(D) Real-time qRT-PCR showing the expression of canonical Hippo pathway target genes (CTGF
AXL and AREG) as well as AMOTL2 in MCF7shMAGI1 compared to the control MCF7shLuc cells and normalized with GAPDH expression
Unpaired two-tailed Student's t-test; *p < 0.05; **p < 0.01; ***p < 0.001
(E) Real-time qRT-PCR showing the expression of two distinct Wnt pathway target genes (AXIN2 and CCND1) in MCF7shMAGI1 compared to the control MCF7shLuc cells and normalized with GAPDH expression
Unpaired two-tailed Student's t-test revealed no statistical differences
(F) WNT reporter activity assay showing the TOP/FOP ratio in MCF7shMAGI1 as compared to MCF7shLuc control cells
these results thus show that the loss of MAGI1 in luminal BCa cells does not promote YAP nor β-catenin signaling
and suggest that these pathways do not mediate the increased tumorigenicity of MAGI1 deficient cells
The loss of MAGI1 tumorigenic phenotypes are associated with p38 stress signaling pathway activation
(A) Western blot analysis showing protein expression and/or activation of Akt and MAPK proliferation signaling pathways as well as p38 and JNK stress signaling pathways in MCF7shMAGI1 compared to MCF7shLuc cells
Western blot experiments have been repeated at least three times
(B) Quantification of the representative Western blot showing protein expression represented in panel A
(C) Real-time qRT-PCR showing the expression of some p38 pathway target genes (ATF3
SOX9 and GATA6) in MCF7shMAGI1 compared to the control MCF7shLuc cells and normalized with GAPDH expression
(D) 2D cell growth assay of MCF7shMAGI1 treated
with the p38 MAPK inhibitor LY2228820 (LY in the figure) compared to MCF7shLuc
Bars represent mean ± SD (n = 6 wells as replicates) of a representative experiment (n = 3)
Note the increased percentage of drop for MCF7shMAGI1 cells at day 8
(E) Quantification of colony numbers of MCF7shMAGI1 cells non treated or treated with LY2228820 grown in anchorage independent conditions (soft agar assay) and represented as fold increase compared to MCF7shLuc cells non treated or treated with the p38 inhibitor (LY in the figure)
(F) 2D cell growth assay (MTT) representing 2D cell growth of MCF7shMAGI1 and MCF7shLuc after transfection of p38asiRNA or CtlsiRNA
Bars represent mean ± SD (n = 10 wells as replicates) of a representative experiment (out of 3)
Unpaired two-tailed Student's t-test; *p < 0.05
(G) Quantification of colony numbers of MCF7shMAGI1 and MCF7shLuc after transfection of p38a siRNA or Ctl siRNA
grown in anchorage independent conditions (soft agar assay) and represented as fold increase compared to MCF7shLuc cells transfected with Ctl siRNA
(H) Western blot analysis showing protein levels of phosphorylated p38 and total p38 in MCF7shMAGI1 cells treated or non-treated (NT) with Blebbistatin (Blebb) or Y-27632
Both inhibitors were used at 10 µM during 2 h and Tubulin that was used as a loading control
(I) Quantification of the representative Western blot showing protein expression and represented in panel E
Phosphorylated p38 was quantified as compared to total p38 to evaluate its activation
Strikingly, treating MCF7shMAGI1 cells with the Rho Kinase (ROCK) inhibitors Y-27632 or Blebbistatin that prevent Myosin-mediated F-actin tension, abolished p38 activation (Fig. 6H,I) and largely decreased elastic cell Young’s modulus (Supplementary Fig
showing that increased ROCK activity and actin strength represent critical events to activate p38 signaling
these ROCK inhibitors treatments could only be maintained for short periods
whether releasing actin tension in MAGI1 deficient cells could suppress their tumorigenicity as would be expected from their effects on p38
investigated whether AMOTs could mediate the effects of MAGI1 to restrict tumorigenesis in breast luminal cells
(A) Western blot of Flag-MAGI1 immunoprecipitates: Flag-MAGI1 transfections were performed in MCF7 cells and endogenous AMOT (upper panels) and AMOTL2 (lower panels) were revealed; Flag blotting was used as the immunoprecipitation control
Note that we could hardly detect Flag-MAGI1 by Western blot in the inputs
even though MAGI1 was well immunoprecipitated
due to sensitivity issues associated with single Flag tag in Flag-MAGI1 used in this typical experiment
(B) Western blot analysis of endogenous MAGI1 immunoprecipitates revealing the presence of endogenous AMOT (upper panels) and AMOTL2 (lower panels)
MAGI1 blotting was used as the immunoprecipitation control (*shows non-specific bands with the anti-MAGI1 antibody)
(C) Schematic of full length MAGI1 and of the point MAGI1 WW domain mutants used (P331A and P390A)
(D) Western blot analysis of Flag-MAGI1 immunoprecipitates on protein extracts from MCF7 cells transfected with HA-AMOT and different Flag tagged MAGI1 constructs
showing that the interaction with AMOT occurred through the second WW domain of MAGI1 (interaction lost in P390A; red)
(E) Western blot analysis of Flag-MAGI1 immunoprecipitates on protein extracts from MCF7 cells transfected with Flag-MAGI1 or Flag-MAGI1 P390A mutant
revealing the interaction of endogenous AMOTL2 with Flag-MAGI1 but not Flag-MAGI1 P390A (red)
(F) Schematic of full-length AMOT and of the point AMOT PPXY mutants used (Y242A and Y287A)
(G) Western-blot analysis of Flag-MAGI1 immunoprecipitates on protein extracts from MCF7 cells transfected with Flag-MAGI1 and different HA-AMOT constructs
showing that the interaction occurs through the second PPXY domain of AMOT (interaction lost in Y287A; red)
Similar levels of interaction were obtained for HA-AMOT/Flag-MAGI1 and HA-AMOT Y242A/Flag-MAGI1 complexes (quantified using the ImageJ software)
(H) Representative immunofluorescence images of endogenous staining for MAGI1 (red; top panels) co-localizing at the plasma membrane (white arrows) with AMOT (green; left) or AMOTL2 (green; right) in MCF7 cells
Note the non-specific nuclear staining for AMOT
(I) Western blot analysis after subcellular fractionation showing the relative amount of AMOTL2 protein in the cytoplasmic and membrane fractions in MCF7shMAGI1 compared to MCF7shLuc cells
Tubulin was used as a cytoplasmic control for the fractionation and for normalization
suggesting that the accumulation of AMOTL2 protein could also be a consequence of increased transcription
Together our results confirm the physical interaction between MAGI1 and AMOTs and show that MAGI1 restricts the total AMOTL2 protein levels
through a mechanism that remains to be established
AMOTL2 mediates the effects of MAGI1 on junctions and on p38 signaling
(A) MTT assay (OD 560 nm) representing 2D cell growth of MCF7shMAGI
MCF7shAMOTL2 and MCF7shMAGI1/shAMOTL2 cells as compared to MCF7shLuc
Bars represent mean ± SD (n = 10 wells as replicates) of a representative experiment (n = 3)
(B) Quantification of colony numbers of MCF7 cells (shMAGI1
shAMOTL2 and shMAGI1/shAMOTL2) grown in anchorage independent conditions (soft agar assay) and represented as fold increase compared to MCF7shLuc cells
Western blot analyses confirmed the 90% knockdown for MAGI1 in MCF7shMAGI1 and MCF7shMAGI1/shAMOTL2 and QPCR data confirmed the 50 to 60% knockdown for AMOTL2 in MCF7shAMOTL2 and MCF7shMAGI1/shAMOTL2 respectively (determined by RT-qPCR and/or Western Blot ; Data not shown)
(C) Western blot analysis showing protein expression and/or phosphorylation (activation) of p38 and JNK stress signaling pathways as well as junctions’ components in MCF7shMAGI1 as compared to MCF7shLuc cells when AMOTL2siRNA was transfected
(D) Quantification of the representative Western blot showing protein expression and represented in panel C
Phosphorylated proteins were quantified as compared to their total protein counterparts to evaluate their activation and junctions’ proteins were quantified as compared to tubulin that was used as a loading control
Upper: Phosphorylated p38/Total p38 protein quantification and Lower: protein/Tubulin quantification
(E) Model for the role of MAGI1 during Luminal BCa
MAGI1 prevents the accumulation of junctional AMOTL2 and E-cadherin as well as ROCK activity thus releasing cellular stiffness
Increased AMOTL2 and ROCK then activate p38 stress signaling responsible for the increased tumorigenicity of MAGI1-deficient cells
Anti and Pro tumorigenic events are highlighted in green and red respectively
we explored the function of the junctional component MAGI1 in breast carcinogenesis and showed that the loss of MAGI1 in luminal BCa cell lines promoted tumorigenesis
we showed that the loss of MAGI1 induced an accumulation of AJ components and increased cell compression behaviors
we showed that the increased tumorigenicity of MAGI1 deficient luminal BCa cells was mediated by p38 stress signaling
we confirmed that MAGI1 interacted with the AMOT family of apical scaffolds and actin linkers
completely suppressed the effect of MAGI1 loss on the activation of p38 and on tumorigenicity
we provided evidence that inhibiting ROCK activity could alleviate the p38 activation
supporting a model in which MAGI1 suppresses luminal BCa by preventing both ROCK and AMOTL2-mediated Junction dysfunction
These observations reconcile the high E-cadherin levels and increased tumorigenicity observed upon MAGI1 loss
and suggest that at least in specific phases of tumorigenesis (e.g
E-cadherin could play a positive role during BCa
and the accumulation of AMOTL2 in the context of MAGI1 mutation could thus represent an alternative mechanism for AMOTL2 expression
extending the relevance of AMOTL2 up-regulation during carcinogenesis
Relaxing actin tension using two ROCK inhibitors (Y-27632 and Blebbistatin)
a key feature mediating tumorigenesis after MAGI1 loss
So how could AMOTL2 and ROCK interact to mediate the effects of MAGI1 loss
They could either (i) be two independent consequences of MAGI1 loss or (ii) they could be linked causally
Due to the toxicity of long term exposures to ROCK inhibitors
we were unable to study whether AMOTL2 stability could be a consequence of ROCK activity
Preliminary results would indicate that AMOTL2 does not control ROCK activity (data not shown)
but more experiments are needed to better determine how MAGI1 controls ROCK activity
and how ROCK and AMOTL2 regulate p38 activity
We observed in MAGI1-deficient cells an increased proportion of cells in S-phase
indicating that these cells might have a slower S-phase
Slow S-phase is classically observed when cells have to overcome a high level of DNA damage
These results highlight the need for further studies to better understand the link between MAGI1 loss
Targeted sequences are listed in the supplementary methods section
T47D and HCT116 human cell lines originated from the TumoroteK bank (SIRIC Montpellier Cancer) and have been authenticated by STR (Short-tandem repeat) profiling and certified mycoplasm-free
Details for culture are added in the supplementary methods
Plasmid transfections were performed in MCF7 cells using Lipofectamine2000 reagent (Invitrogen) according to the manufacturer's directions
Cell extracts were assayed for protein expression 24–48 h post-transfection
Concerning AMOTL2siRNA and p38α siRNA transfection (Dharmacon siGENOME #M-01323200-0005 and #L-003512-00-0005 respectively)
a final concentration of 100 nM was used using Lipofectamine2000 reagent as well
T47DshRNA or HCT116shRNA cell lines were extracted
RNAs were extracted from cells using RNeasy plus kit (Qiagen) and cDNAs were prepared starting from 1 µg of RNAs using the Superscript III reverse transcriptase (Invitrogen) and following manufacturer's directions
Real time quantitative PCR was then performed on cDNAs using SYBR Green I Mastermix (Roche) according to the manufacturer's conditions on a Light Cycler 480 device (Roche)
All primers used are listed in the supplementary methods
Breast cancer samples were retrospectively selected from the Institut régional du Cancer de Montpellier (ICM) pathology database using the following inclusion criteria: chemotherapy-naïve at the time of surgery and estrogen (ER)
progesterone (PR) receptor and HER2 status available
TMA construction are detailed in the supplementary methods section
Tumor samples were collected following French laws and declared to the French Ministry of Higher Education and Research (Biobanque BB-0033-00059; declaration number DC-2008-695)
Informed consent was obtained from all participants (adult breast cancer patients)
All patients were informed about the use of their tissue samples for biological research
All experimental protocols were approved by the ethics and licensing committee CORT (Comité de Recherche Translationnelle de l’Institut regional du Cancer de Montpellier (ICM))
Four µm thin sections of the TMA were mounted on Flex microscope slides (Dako) and allowed to dry overnight at room temperature before immunohistochemistry (IHC) processing
MCF7shLuc and MCF7shMAGI1 cell suspensions were obtained by trypsinization and then filtered using 30 µm cell strainer (Miltenyi)
Filtered cells were immediately seeded in 96 well plates coated with 1% Poly (2-hydroxyethyl methacrylate; Sigma Aldrich) at a density of 200 or 50 cells per well
Cells were grown in MEBM basal medium supplemented with B27 without vitamin A (50X)
Cells were incubated at 37 °C with 5% CO2 during 5 days
Protein extracts were prepared in lysis buffer (NaCl 150 mM
EDTA-free protease inhibitors (Roche #11873580001) for 30 min on ice before centrifugation
Immunoprecipitations were performed overnight at 4 °C on a rocking wheel using either mouse anti-MAGI1 antibody for endogenous immunoprecipitations or anti-HA antibody and EZview Red anti-FLAG M2 affinity gel (Sigma-Aldrich #F1804) for co-immunoprecipitations
Protein G sepharose was then added to the MAGI1- or HA- immunoprecipitates for 1 h at 4 °C before extensive washes
washes were performed followed by protein elution by competition with 3XFLAG peptide (150 ng/µL final concentration) during 1 h at 4 °C
The different immunoprecipitates were then submitted to Western blotting for detection of protein complexes
Subcellular fractionation of cultured human cell lines was performed as previously described on-line (http://www.bio-protocol.org/e754)
2D cell growth assay was analyzed using MTT (Thiazolyl Blue Tetrazolium Bromide (Sigma Aldrich #M2128))
cells seeded in 96 well plates were stopped from day 0 to day 7 by incubation with MTT solution (0.5 mg/mL final concentration) during 4 h at 37 °C
cells were incubated with DMSO to solubilize the formazan crystals formed in the presence of MTT
10,000 cells were seeded in Ultra-Low Attachment 96 well plates (Costar) cultured in their regular medium supplemented with 15% FCS
all cells formed 3D spheroids that can be further analyzed by perimeter and circularity measurements
Pictures of spheroids were taken 3 days after seeding cells to assay the ability of cell lines to form spheroids and both the perimeters and the circularity of spheroids were calculated
Circularity was calculated (4px(area/(perimeter)2) where 1 is considered as a perfect circle
The different MCF7shRNA cell lines were plated at 3 × 106 cells per 60 mm plates
10 µM of Ralimetinib (LY2228020; Selleckchem #S1494) was added and 24 h later cells were collected and counted to be plated for the different experiments (Ralimetinib treatment is maintained throughout the experiments)
10,000 cells were plated in 12-well plates before proceeding to the assay detailed below
The same experiments were conducted with another p38 inhibitor using 10 µM of Pexmetinib (ARRY-614; Selleckchem #S7799)
SRB proliferation assay was performed as detailed in the supplementary methods
The treatments of MCF7shRNA cell lines with either Blebbistatin (Selleckchem #7099) or Y-27632 (Selleckchem #S1049) were both performed at a final concentration of 10 µM and cells were treated during 2 h before being lysed for Western blot analyses
A first layer of 0.8% Noble agar (Sigma Aldrich #A5431) was prepared in 12-well plates and left at 4C during 1 h for the agar to solidify gently
The plate was kept at 37C before the cell-containing agar layer was prepared
5,000 or 10,000 cells were imbedded in the second layer containing 0.4% Noble agar on top of the first layer
fresh medium was added on top of the cells
MCF7 cell lines were cultured during 14 to 21 days before Crystal violet coloration (0.01% final concentration; Sigma Aldrich #C0775) or MTT assay (1 mg/mL final concentration)
MCF7shRNA and HCT116shRNA cell lines were injected subcutaneously in six-week-old female athymic Nude-Foxn1 mice (Envigo)
Both flanks of each mouse were injected with cells mixed with Matrigel (106 cells injected for HCT116; 10 × 106 cells injected for MCF7)
Mice injected with MCF7 cells were subjected to neck dropping with 50 µl of β-estradiol (1.5 mg/mL diluted in ethanol) to stimulate MCF7 cell growth
Animal procedures were performed according to protocols approved by the ethics and licensing committee of the Direction Générale de la Recherche et de l’Innovation (Ministère de l’Enseignement Supérieur de la Recherche et de l’Innovation)
and this study was carried out in compliance with the ARRIVE guidelines
Choosing the right cell line for breast cancer research
A refined molecular taxonomy of breast cancer
Composition and formation of intercellular junctions in epithelial cells
Adherens Junction and E-Cadherin complex regulation by epithelial polarity
Cadherins and cancer: how does cadherin dysfunction promote tumor progression?
Tight junctions as regulators of tissue remodelling
Tensile forces and mechanotransduction at cell–cell junctions
Mechanical force-driven adherens junction remodeling and epithelial dynamics
Mechanical strain induces E-cadherin-dependent Yap1 and β-catenin activation to drive cell cycle entry
The epithelial circumferential actin belt regulates YAP/TAZ through nucleocytoplasmic shuttling of merlin
Actomyosin contractility provokes contact inhibition in E-cadherin-ligated keratinocytes
E-cadherin mediates contact inhibition of proliferation through Hippo signaling-pathway components
Yap1 acts downstream of α-catenin to control epidermal proliferation
α-catenin is a tumor suppressor that controls cell accumulation by regulating the localization and activity of the transcriptional coactivator Yap1
Propagating wave of ERK activation orients collective cell migration
Actomyosin contractility modulates Wnt signaling through adherens junction stability
Integrin-dependent activation of the JNK signaling pathway by mechanical stress
Signal integration by JNK and p38 MAPK pathways in cancer development
The E-cadherin-catenin complex in tumour metastasis: structure
Mechanosensitive adhesion complexes in epithelial architecture and cancer onset
alternatively spliced tight junction protein
a junctional cell adhesion molecule interacting with a tight junction protein
Magi is associated with the Par complex and functions antagonistically with Bazooka to regulate the apical polarity complex
Drosophila MAGI interacts with RASSF8 to regulate E-Cadherin-based adherens junctions in the developing eye
A genome-wide functional screen shows MAGI-1 is an L1CAM-dependent stabilizer of apical junctions in C
AmotL2 links VE-cadherin to contractile actin fibres necessary for aortic lumen expansion
Regulation and involvement in cancer and pathological conditions of MAGI1
Downregulation of MAGI1 associates with poor prognosis of hepatocellular carcinoma
MAGI-1 expression is decreased in several types of human T-cell leukemia cell lines
MAGI1 inhibits cancer cell migration and invasion of hepatocellular carcinoma via regulating PTEN
MEK1 is required for PTEN membrane recruitment
and the maintenance of peripheral tolerance
Restoration of MAGI-1 expression in human papillomavirus-positive tumor cells induces cell growth arrest and apoptosis
Human T-cell leukemia virus type 1 Tax protein interacts with and mislocalizes the PDZ domain protein MAGI-1
Identification of MAGI1 as a tumor-suppressor protein induced by cyclooxygenase-2 inhibitors in colorectal cancer cells
The E-cadherin/AmotL2 complex organizes actin filaments required for epithelial hexagonal packing and blastocyst hatching
AmotL2 integrates polarity and junctional cues to modulate cell shape
The Hippo pathway in normal development and cancer
Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein
The Hippo pathway: regulators and regulations
Hippo pathway-independent restriction of TAZ and YAP by angiomotin
Defining the protein-protein interaction network of the human hippo pathway
Angiomotin regulates endothelial cell–cell junctions and cell motility
Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1
An online survival analysis tool to rapidly assess the effect of 22,277 genes on breast cancer prognosis using microarray data of 1,809 patients
a new potential tumor suppressor gene in estrogen receptor positive breast cancer
The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway
The Hippo signaling network and its biological functions
A central role for p38 MAPK in the early transcriptional response to stress
and the anti-tumoral response to taxanes in breast cancer cells
Roles of p38α mitogen-activated protein kinase in mouse models of inflammatory diseases and cancer
Dual function of p38α MAPK in colon cancer: suppression of colitis-associated tumor initiation but requirement for cancer cell survival
p38 MAPK and JNK are highly expressed and active in the stroma of human colonic adenomatous polyps
The nuclear translocation of the kinases p38 and JNK promotes inflammation-induced cancer
Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions
E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells
Yang, J. et al. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat. Rev. Mol. Cell Biol. https://doi.org/10.1038/s41580-020-0237-9 (2020)
Persistent E-cadherin expression in inflammatory breast cancer
E-cadherin’s dark side: possible role in tumor progression
E-cadherin is required for metastasis in multiple models of breast cancer
The RNF146 and tankyrase pathway maintains the junctional Crumbs complex through regulation of angiomotin
Tankyrase inhibitors target YAP by stabilizing angiomotin family proteins
AMOTL1 promotes breast cancer progression and is antagonized by merlin
AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion
Tumor cell dormancy: threat or opportunity in the fight against cancer
Opposing roles of mitogenic and stress signaling pathways in the induction of cancer dormancy
p38alpha MAP kinase as a sensor of reactive oxygen species in tumorigenesis
P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment
TAZ is required for metastatic activity and chemoresistance of breast cancer stem cells
The Hippo transducer TAZ confers cancer stem cell-related traits on breast cancer cells
YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
An in vitro recombination method to convert restriction- and ligation-independent expression vectors
FOXO3a and the MAPK p38 are activated by cetuximab to induce cell death and inhibit cell proliferation and their expression predicts cetuximab efficacy in colorectal cancer
and puncture of model membranes at the molecular scale
crosstalk-free correlative AFM and confocal microscopies/spectroscopies
Apical surface supracellular mechanical properties in polarized epithelium using noninvasive acoustic force spectroscopy
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Costa from lentivectors' production facility of SFR Biosciences (UMS3444/CNRS
Soirat for technical help with the mammosphere formation assay and PE Milhiet (CBS
France) for helpful discussion and AFM set up
All plasmids obtained from Addgene are detailed in the Material and Methods section and all references have been included
The CBS is a member of the France-BioImaging (FBI)
national infrastructures supported by the French National Research Agency ANR-10-INBS-04-01
This work was supported by grants from Fondation ARC and Ligue Régionale Contre le Cancer (34) to LHM and AD
DK is supported by Ligue Nationale Contre le Cancer
VS and EB were supported by Fondation de France
These authors contributed equally: Emilie Bousquet Mur and Maicol Mancini
These authors jointly supervised this work: Lisa Heron-Milhavet and Alexandre Djiane
Lisa Heron-Milhavet & Alexandre Djiane
The authors declare no competing interests
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations
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Fifteen-year-old Francesca Cesarini was born with no hands and with only one leg
So her mother was more than a bit surprised when her daughter told her she wanted to be an acrobatic pole dancer
"I don't know if maybe I saw it on social media first
I just know that I (woke up and) went to her and I said that I wanted to do pole dance," Cesarini said
in 2021 she competed in the International Pole Sports Federation's virtual world pole and aerial championship
pole dancers from around the world submitted videos of their performances and were judged virtually
She was the only athlete to compete in the disability category and was awarded the gold medal
Francesca wears braces on her teeth and a black plastic choker necklace
sings the latest pop song while walking with her best friend
But she chose an increasingly popular sport that anyone would find difficult
"It makes me feel free," she said in her family's apartment near Perugia in central Italy
where she practices at home and trains with her coach Elena Imbrogno in a local gym
Imbrogno told her to try it again but with her head just a bit straighter
"There are some difficult elements (like) when you have to contort yourself or maybe you have to hold on with just an arm
but when he she was about eight years old she decided to stop using artificial forearms because she found them inhibiting
"She still doesn't want them," said her mother Valeria Mencaroni
“Francesca is a girl who knows what she wants
She wants to achieve certain goals," said her father Marco Cesarini
and so she does everything with what she has."
she did it without any help from Harry Potter's wand
(Photo editing Kezia Levitas; Additional reporting Emily Roe and Elly Biles; Writing Philip Pullella; Editing William Maclean; Layout Kezia Levitas)
Francesca studies with the help of her stepmother Cristina
Francesca sings and dances with her cousin
Francesca checks an illustration of an exercise on her phone while practicing pole dancing at home
Francesca has lunch with her father Marco after her training session
Francesca walks with her father Marco after lunch
Francesca poses with the gold medal she won in the disability category at the the Virtual International Pole Sports Federation World Pole and Aerial Championship 2021
Francesca trains with her coach Elena Imbrogno
Francesca trains with the help of her teammate Marta Persichini
Francesca practices pole dancing at home while her mother Valeria watches
Francesca reads "Harry Potter and the Chamber of Secrets" in her bedroom
Krugger has two AMD World Championship titles to his name
and he’s known for building cleaner-than-factory bikes
He backs up his craftsmanship with amazing attention to detail: this Scrambler is loaded with touches that all but a keen eye would miss
This meant keeping the original teardrop tank—enhancing rather than replacing it
So he unscrewed the tank’s side panels
He’s also tweaked the Scrambler’s stance by dropping the front fork a hair under two inches
Ducatisti will notice that the prominent swingarm has disappeared
The exhaust system is custom too—crafted from various Ducati headers
Krugger’s performed a number of other nip-and-tucks
the speedo’s now on the left hand side
and the turn signals have been ditched in favor of a pair of bar ends
The handlebars and off-road foot pegs are Scrambler aftermarket items; the latter are rubber-mounted via custom-made brackets
Rounding everything off is a jaw-dropping satin grey paint job
Krugger Motorcycles | Images by Thierry Dricot
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Today the Ioda TR004, the newborn Moto3 from the Terni factory (presented on June 13th in Barcelona) took its first "steps" on the Umbrian circuit of Magione
In the saddle was Armando Pontone (already winner of the Moto3 Cup in the 2011 Italian Speed Championship riding the IodaTR001)
who did the first Shake Down for the bike designed by engineers Luis Tintorè and Adelio Francia
The TR004 is the fourth bike from the Terni factory led by Giampiero Sacchi
and represents the concentration of the experiences of the two TRs (the 001 and the 002) which have raced in Moto3 since its debut as a world category
the first in the Italian Speed Championship
the second in the world championship in 2012
raced last season in the MotoGP class with Danilo Petrucci
In the coming weeks the bike will be taken to the track by Johann Zarco
current Came IodaRacing Moto2 rider and high-level eighth-litre rider
We remind you that the motorbike is on sale in two versions
Complete motorbike with Honda engine (+ Geo engine kit) + electronics with garden control unit and dashboard: €110.425,00 (+ VAT) TR004 KIT – TR004 chassis + shock absorber + rear rim + rear brake disc: €73.450,00 (+ VAT) – this kit does not include: engine
while the wiring for the electronics is supplied because dedicated
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The fourth round of the Italian F4 Championship
returns this weekend at Magione with Malta Formula Racing fielding four cars
Young American Zack Dante will be on board one of the cars with the other three registered under F&M Adria Raceway who are managed by Danilo Rossi and Marco Ubaldi under the technical supervision of Roberto Venieri
Confirmed in F&M’s line-up are Mattia Drudi
who currently occupies fifth spot in the championship standings after registering his first victory at the event in Imola
India’s Mahaveer Raghunathan and Giovanni Altoe
he was among the fastest drivers at the end of official testing that took place last week at Vallelunga
Keith Camilleri will be absent from this round for personal reasons
The schedule for this weekend kicks off today with the first two free practice sessions of 40 minutes each
the first one (28 minutes plus one lap) starting at 9am
Highlights from the opening two races and the live broadcast of the final race will be shown on TVM2
please register for free or log in to your account
The fourth round of the Italian F.4 Championship powered by Abarth returns this weekend
with Malta Formula Racing fielding 4 cars: one for young American Zack Dante
with the other three registered under F&M Adria Raceway who are also managed by Danilo Rossi and Marco Ubaldi under the technical supervision of Roberto Venieri
with the live broadcast of Race 3 will be shown on TVM 2 starting from 4:10pm with Keith Camilleri as guest commentator along with Chris Cauchi and Edwin Saliba
Luigi Mangione on Monday pleaded not guilty in New York to charges including the "terrorist" murder of UnitedHealthcare CEO Brian Thompson
New York - Luigi Mangione on Monday pleaded not guilty in New York to state charges including the "terrorist" murder of UnitedHealthcare CEO Brian Thompson
Mangione wore a white shirt under a burgundy sweater
and was shackled during his appearance in a Manhattan court where he was flanked by police officers
where he was arrested at a McDonald's restaurant
with many seeing Mangione as a hero and feeling little sympathy for the executive of a company that denied insurance claims more than any other
Mangione could face life imprisonment with no parole
he could technically face the death penalty
His attorney, Karen Friedman Agnifilo, has sought clarity on how simultaneous federal and state charges would work
on December 9 following a tip from staff at a McDonald's restaurant
He had traveled to New York by bus from Atlanta about 10 days before the crime
After checking into a Manhattan hostel with a fake ID
he allegedly scoped out the victim's hotel and the conference venue where the shooting took place
walked up behind him and fired several gunshots from a pistol with a silencer
Cover photo: POOL / GETTY IMAGES NORTH AMERICA / Getty Images via AFP
More on Murder:
As many unravel his confusing and sometimes contradictory political beliefs
others are wondering who his family and parents are
Here's what we know about the family that Mangione comes from
Luigi is actually from a fairly wealthy Baltimore family
His parents own a house at the Hayfields Country Club
and the Mangione family also owns the Baltimore-based radio station WCBM-AM and an assisted-living facility
the family expressed shock that one of their own had been accused of such a heinous crime
we cannot comment on news reports regarding Luigi Mangione," the family's statement said
"We only know what we have read in the media
Our family is shocked and devastated by Luigi's arrest
We offer our prayers to the family of Brian Thompson and we ask people to pray for all involved
is that Luigi comes from a family with some means
im tryna watch the luigi mangione press conference on tt and they won’t stop putting filters on the cops lmaooo pic.twitter.com/KOCdPL9jLi
Although he came from a prominent family, perhaps the most relevant detail in Mangione's biography is the fact that he appears to have had issues with his back
His Twitter profile prominently features an image of a spinal X-ray that shows four screws in the spine
The X-ray apparently shows "lumbar spine with posterior spinal instrumentation
possible fusion," a procedure that involves using screws or rods to stabilize a spine and is used to treat a number of spinal issues
Mangione's Goodreads account also seems to indicate that he read several books about back issues
although the account has yet to be definitively tied to him
many have speculated that this back issue may have fed into his motivation for committing the murder
even as some were surprised that a young man from a family as wealthy as his would ever struggle to pay for his medical bills
When he was arrested, Mangione was found with writings about the healthcare industry that have been described by some as a "manifesto." As details about his condition and his motivation continue to reveal themselves
many are eager to learn more about the young man who has taken social media by storm and led so many to share their own stories of mistreatment at the hands of the American healthcare system
even as they reckon with the murder he is suspected of committing
UnitedHealth Murder Suspect Luigi Mangione's Political Views Are Now in Question Following Arrest
UnitedHealth CEO Murder Suspect Luigi Mangione Wrote a Manifesto Against the Healthcare Industry
According to Luigi Mangione's Goodreads Account, He's Into Psychedelics and Dr. Seuss
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On December 4th, 2024, at 6:45 ET, an assassin killed United Healthcare executive Brian Thompson in New York City in front of the Hilton Hotel. Video of the assassination shows the assassin with what appears to be a pistol with a suppressor attached
while manually working the action at least twice
This would leave two shell cases and a potentially loaded round or three shell cases at the crime scene
a suspect was identified in a McDonald’s at about 0914 a.m
Altoona police officers approached the suspect
who was wearing a mask and a beanie-type cap
was seated at a table with a silver computer and a backpack
Officers asked Magione to pull down his medical mask
They recognized the suspect as matching images of the assassin in New York
The officers asked if the suspect had been in New York City recently
The officers then asked for identification
The suspect offered a New Jersey Driver’s license bearing the name of Mark Rosario
When the officers attempted to validate the license
The suspect was told he was under investigation
The suspect then identified himself as Luigi Mangione
Magione was placed under arrest for forgery and false identification to law enforcement
From the Altoona Pennsylvania police report:
During a search of the Defendant’s backpack
Officers located a black 3D-printed pistol and a black silencer
The pistol had a metal slide and a plastic handle with a metal threaded barrel
The pistol had one loaded Glock magazine with six nine-millimeter full metal jacket rounds
There was also one loose nine-millimeter hollow point round
Magione was not charged with possessing an unregistered silencer/suppressor because Pennsylvania does not prohibit the possession of silencers/suppressors
defines prohibited offensive weapons as “firearms specially made or adapted for concealment or silent discharge.” A typical silencer does not meet this definition because it is not a firearm under Pennsylvania state law and does not produce a silent discharge
As reported on Reuters.com
Witness Christian Diaz heard shots from just outside the University Club
The assassination was in front of the New York Hilton Midtown
the University Club is over 300 yards from the front of the New York Hilton Midtown
The weapon used in the assassination was far from silent
Before 1:59 p.m., December 11, 2024, AP reported the firearm found in Magione’s backpack matched shell casings found at the scene of the crime in NYC
the suspect firearm was test-fired with similar ammunition
The cases were compared to determine extractor
and firing pin marks between different jurisdictions
No serial number was needed for this investigation
This correspondent wonders if the Altoona Police Department might have an agreement with U.S. Immigrations, Customs and Enforcement (ICE), which has a sophisticated ballistics laboratory in Altoona
Some have claimed the CEO of UnitedHealthcare is “greedy.” Brian Thompson’s salary was one million dollars a year. With stock options, which are not guaranteed, the total compensation has been estimated at 10 million dollars a year
The number of people covered by UnitedHealthcare is 49 million
The compensation of Brian Thompson amounts to between 2 cents and 20 cents per year per person covered by UnitedHelathcare
The total income of the portfolio of UnitedHealthcare managed by Thompson was 74 billion in the last quarter
Thompson’s share was about 1/3 of 1/100 of 1 percent of the income he managed (.0000338)
was on the University of Wisconsin Pistol Team for four years
and was first certified to teach firearms safety in 1973
He taught the Arizona concealed carry course for fifteen years until the goal of Constitutional Carry was attained
He has degrees in meteorology and mining engineering
and retired from the Department of Defense after a 30 year career in Army Research
I wonder if the “matched shell casings” was just that they were the same caliber and headstamp
It’s not like we expect real firearms accuracy from the media
This is just more of the blessed dalliances of OUR GOVERNMENT
This CEO was a potential loose end in an insider trading scam
I wonder how many of our elected officials owned said stock and miraculously got out without losing their short while the general public took it right in the teeth
Plus our beloved leaders are NEVER going to let an opportunity pass to attempt to take another hack at chopping our constitutional right into match sticks
you shut up a potential squealer AND get to try to gin up fear and support for more restrictive gun… Read more »
you keep insisting on inserting facts into the discussion of so-called ghost guns
If we are required to rely on actual reality
the progs won’t be able to infringe on any of our rights and SAF
GOA and other Constitution based organizations would all go out of business./sarc off
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