Please enable JS and disable any ad blocker Back to Academics Explore Programs Colleges & Schools Beyond the Classroom Academic Support Academic Resources Back to Research Research Opportunities Funding & Processes Support & Services Back to About Who We Are Leadership & Faculty Back to Student Life Campus Living Facilities Clubs & Organizations Wellness & Support Student Success Resources & Guides Back to Tuition & Aid Tuition & Costs Financial Aid Other Funding Options Back to Admissions Apply Visit Counselors & Support Back to Alumni Back to Athletics Back to Events The University of Tulsa has announced the acquisition of Fab Lab Tulsa which provides access to digital fabrication tools and resources throughout the community through membership and programming The move is part of TU’s ongoing efforts to promote innovation and aligns with the university’s global reputation in engineering organizational studies is one of the largest majors in The University of Tulsa’s Kendall College of Arts & Sciences the program provides students a wide range of knowledge and skills rather than limiting them to a single discipline Anne Grau has been involved in geology for three decades – working for energy leaders such as EOG Resources and Total Energies – and definitely knows what it’s like to be the only woman in the room “Being a woman in the oil and gas industry often meant I was one woman in 200 at […] The University of Tulsa’s College of Law congratulates alumna Sara Hill (JD ’03) as she becomes the first Native American woman to serve as a federal judge in Oklahoma This historic appointment marks a significant milestone in the state’s legal landscape Senate on Tuesday voted overwhelmingly to confirm Hill The University of Tulsa Department of Psychology has a wide variety of faculty-led research labs Relaxation & Rescripting Therapy for Chronic Nightmares study to the Psychophysiology Laboratory for Affective Neuroscience lab TU offers students the opportunity to participate in ongoing research and even publish their findings and since then the journal has become an internationally esteemed publication known for its publishing of critical […] Jesse Haynes (B.A. ’19, MBA ’20) knows what hard work looks like. Raised in the Tulsa suburb of Skiatook, Haynes is a bestselling author on Amazon, the former host of an award-winning podcast, a marketing consultant and writer for the Forbes Business Council, and now the co-founder a new eyewear company, Solaro Shades Haynes saw the opportunity to break into the baseball space because of Paul’s social media following Mark had just over half a million followers across his social channels and they were all a very niche audience: baseball and softball parents most of whom were looking for an alternative to paying $200 for high-end baseball sunglasses,” he said “This gave us the perfect opportunity to launch a creator brand.” Solaro Shades have been adopted by MLB players Every pair of sunglasses comes with five interchangeable lenses and a limited lifetime warranty Haynes is a proud graduate of The University of Tulsa’s Kendall College of Arts & Sciences (media studies) and Collins College of Business a combination that he credits with allowing him to not only identify problems in the market Solaro Shades has become the only major sports sunglasses company to have a dedicated softball line With a liberal arts education and books such as “Invisible Women” in hand Haynes knows that the business practice of “pink it and shrink it” has failed a million-plus softball players and he wants to do what he can to advocate for this underserved market with consultation from professional and Olympic softball players and marketing efforts led by Abby Jones (B.S.B.A a recent Golden Hurricane softball letterwinner Solaro has developed a product line designed by women for female athletes while finding ways to produce their high-end shades at the same factory as Oakley for often less than half the price we need to turn a profit to grow the business,” Haynes said “But the true value to me is being able to help real people in the real world Baseball and softball are great sports but also have one of the most expensive barriers to entry By selling premium glasses for a much more affordable price we’re helping make the game more affordable and accessible to anybody who wants to play it.” Convention would wrongly suggest that the best life is to be “paid in the shade.” For Haynes “Baseball and softball teach self-discipline team communication and many other valuable life skills,” he said I learned those lessons right here in the Tulsa heat and the TU light and I hope that our sunglasses company continues to grow and help young athletes follow the same path – all while saving a little money “We just announced our next endeavor: a lineup of blue light-blocking screen glasses designed by the popular YouTuber LoverFella,” Haynes shared they’ll be great for anybody who looks at a screen more than a person should – so Whether you’re looking to study the creator economy of the digital age or dive into it head-first with your own company, UTulsa has what you need to make it happen. Explore our media studies and MBA programs to learn how you can achieve your academic and career goals College Baseball, MLB Draft, Prospects – Baseball America all part of the plan from Solaro Shades to make what they call a high-quality affordable pair of sport sunglasses aimed at both the baseball and softball markets “Parents are already sending little Timmy to the plate with $1,200 worth of equipment, and the last thing they want is a $200 pair of sunglasses,” Jesse Haynes, Solaro Shades co-founder “We want to lower the barrier of entry to the game with a lower price point The sunglasses have the same quality and craftsmanship as premium brands a baseball comedian with a following of about 750,000 across all his platforms who regularly headlines entertainment at travel ball tournaments The pair crafted sport sunglasses—an Olympic cyclist is also wearing them—but focused on baseball because of Paul’s ties to the industry The company also crafted a specially designed softball frame working with multiple players to ensure it fit the shape of female faces Haynes says that beyond the same quality and craftsmanship as the premium brands at a much lower price point another major competitive advantage for the Tulsa-based company is borrowed from the cycling industry: Multiple lenses come with every pair of sunglasses Solaro Shades currently offers five lenses: a primary color lens to match the frame 4 a new two-in-one frame where the bottom of the frame snaps off allowing players to wear the glasses as a closed or open frame With the tech specs and business-side dialed in—the brand features a limited lifetime guarantee that includes a replacement of the first pair bought with no questions asked—the growth of the company has largely come thanks to a growing excitement over the product at every level Solaro Shades started in the travel ball space thanks to Paul attending so many tournaments each year Major League Baseball players were soon taking notice and reaching out to Paul asking for pairs The player and the brand did a special colorway tribute in a nod to his Honduran roots with 10% of the sales donated to a nonprofit in his hometown baseball agents were taking notice and reaching out let’s do a custom limited drop,” Haynes says “That is the direction that we hope to take.” And that’s how the Abreu design materialized but Haynes says they wanted to “do something with you and say thanks.” The Abreu 1 shades launch Sept Solaro gives the players an option to take a cut of the sales themselves or donate them to a charity of their choice And as the collaborations grow (Solaro also partnered with Stinger Sports on two projects) teammates often take notice and start wearing pairs as is the case with the Red Sox and a range of Savannah Bananas players ahead of the Mauldin colorway While MLB and top Division I college players wearing Solaro Shades certainly gives the company credibility Haynes says the focus is still on providing a lower-cost option to the travel ball player “We only work with athletes I would want my 12-year-old to look up to,” Haynes says joking that as a 27-year-old he doesn’t have a 12-year-old himself “We work with really good dudes in the game.” we talk about names to know in the upcoming Top 100 Prospects update crown jewel of the 2024 international free agent class tops the Hot Sheet after slashing .533/.667/.867 last week Presenting 10 Statcast standouts from the past week of minor league action led by arguably the top pitching prospect in the game 1 team in the College Baseball Top 25 rankings after another wild weekend Cooper are taking a look at basement dwellers in the AL and NL BA college writers Jacob Rudner & Peter Flaherty break Chris Lemonis’ surprise firing at Mississippi State and lots more Geoff Pontes & Dylan White highlight prospects who could be playing themselves into the Fantasy Top 100 we talk about Shedeur Sanders’ NFL Draft slide and why it wouldn’t happen in the MLB Draft Ben and Carlos talk about Red Sox and Yankees pitchers with physicality and stuff who are off to hot starts in 2025 On this week’s episode of the Baseball America Draft Podcast Carlos and Peter hop on to briefly talk about their relationship to the NFL draft… Read the newest magazine issue right on your phone People hold a banner reading "Cercola is praying for you Come on get up and walk" (refering to Lazzarus) at the statue of John Paul II outside the Gemelli University Hospital on March 6 Pope Francis had a stable day at Rome's Gemelli Hospital which included calling the Catholic parish in Gaza and increasing his respiratory and mobility exercises In a March 5 statement, the Vatican said the 88-year-old pontiff "remained stable" throughout the day and experienced no episodes of respiratory difficulty or failure The Vatican also confirmed he continued to receive high-flow oxygen through the nose as planned The Pope spent Wednesday sitting in a chair and participated in the Ash Wednesday blessing ritual from his private apartment on the 10th floor of Gemelli Hospital he received the ashes and Eucharist from the celebrant during the morning ceremony Pope Francis made a phone call to Father Gabriel Romanelli the priest of the Holy Family parish in Gaza and a fellow Argentine This contact with the Gaza parish comes amid ongoing concerns about the situation in the region The pontiff also conducted some work activities throughout the morning and spent the afternoon continuing with his duties despite his hospitalization Vatican doctors are maintaining a "guarded" prognosis given the complexity of his clinical status which includes factors such as his advanced age and underlying chronic respiratory illness The pontiff is now approaching three weeks of hospitalization after being admitted to Gemelli on February 14 for treatment of a complex respiratory infection and double pneumonia Pope Francis has experienced several fluctuations in his condition with periodic respiratory crises necessitating continuous high-flow oxygen and nighttime use of non-invasive mechanical ventilation This treatment involves sealing an oxygen mask around his nose and mouth to create pressure that assists with inhalation The Vatican reported that twice in the past week the Pope experienced bronchospasms – a tightening and restriction of the tubes connecting the lungs to the windpipe – that required suctioning and ventilation treatment the ventilator is now removed during daytime hours with the Pope receiving oxygen through his nose while continuing to perform respiratory exercises The Vatican statement indicated that Pope Francis has increased his respiratory physiotherapy and active motor therapy aimed at improving his mobility and reducing oxygen dependency Pope Francis was unable to preside over the traditional Ash Wednesday procession and Mass which was instead celebrated by Italian Cardinal Angelo De Donatis major penitentiary of the Vatican's Apostolic Penitentiary A nightly rosary prayer for the Pope's health and recovery is being held in St attended by various cardinals and members of the Roman Curia residing in Rome Wednesday's service was scheduled to be led by Italian Cardinal Marcello Semeraro prefect of the Vatican's Dicastery for Saints Causes The British police launched an urgent operation to stop Iranian terror cells operating within the country The president has proposed implementing a 100% tariff on films produced outside the United States "I don't think we should be bombing foreign countries on behalf of other foreign countries Analysis  Archaeology Blogpost Business & Finance Culture Exclusive Explainer Environment Features Health In Brief Jewish World Judea and Samaria Lifestyle Cyber & Internet Sports Diplomacy  Iran & The Gulf Gaza Strip Politics Shopping Terms of use Privacy Policy Submissions Contact Us The first issue of Israel Hayom appeared on July 30, 2007. 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[contact-form-7 id=”508379″ html_id=”isrh_form_Newsletter_en” title=”newsletter_subscribe”] Volume 9 - 2022 | https://doi.org/10.3389/fcvm.2022.1060716 The discovery that cardiac sarcomere proteins are substrates for S-glutathionylation and that this post-translational modification correlates strongly with diastolic dysfunction led to new concepts regarding how levels of oxidative stress affect the heartbeat Major sarcomere proteins for which there is evidence of S-glutathionylation include cardiac myosin binding protein C (cMyBP-C) Our hypothesis is that these S-glutathionylated proteins are significant factors in acquired and familial disorders of the heart; and We consider the molecular mechanisms for these effects in the context of recent revelations of how these proteins control cardiac dynamics in close collaboration with Ca2+ fluxes These revelations were made using powerful approaches and technologies that were focused on thin filaments Here we integrate their regulatory processes in the sarcomere as modulated mainly by neuro-humoral control of phosphorylation inasmuch evidence indicates that S-glutathionylation and protein phosphorylation promoting increased dynamics and modifying the Frank-Starling relation Earlier studies demonstrated that in addition to cTnI as a well-established biomarker for cardiac disorders serum levels of cMyBP-C are also a biomarker for cardiac disorders We describe recent studies approaching the question of whether serum levels of S-glutathionylated-cMyBP-C could be employed as an important clinical tool in patient stratification early diagnosis in at risk patients before HFpEF and as a guide in developing future therapies Our findings were confirmed and extended by other laboratories more work needs to be carried out to understand the role of S-glutathionylation more completely in early and late stages of cardiac disorders and in their usefulness as serum biomarkers in diagnosis and stratification of patients there have been significant investigations contributing to a new and dynamic evolution in understanding the structure and function of all three of the filaments of the cardiac sarcomere Detailed accounts of these advances are in recent publications to which we refer in the present paper in the context of our focus on oxidative modifications of cMyBP-C Adding to the complexity of the disposition of proteins in relaxed and active sarcomeres is evidence that these interactions are biased toward interactions with actin-Tm in the low Ca2+ inhibited state of the thin filament and more toward interactions with myosin heads at activating levels of Ca2+ As discussed below these interactions are also modified by phosphorylation and by titin induced strain with stretch stabilization of the state of distensibility of titin occurs with aggregation of distal Ig domains of parallel titin strands Variations in this mechanism produce a range of values of passive tension and can affect length dependent activation (LDA) Evidence indicates that stretch of titin signals interactions with the C-terminal domains of cMyBP-C that are transmitted to the cMyBP-C N-terminal domains which promote interactions with actin-Tm and activation of the thin filament which occur in control of contraction and relaxation dynamics and in the Frank-Starling relation are in a state of evolution in our understanding This discussion includes descriptions of accessible Cys residues expressed in each of these proteins that are targeted by S-glutathionylation Addition of the negatively charged GSH tripeptide modifies function alters signaling via protein phosphorylation The concept includes the idea that a diastolic mechanism governed by modifications in titin and troponin-tropomyosin engages ahead of and controlling the systolic state They concluded that with beta-adrenergic stimulation phosphorylation of cMyBP-C is mainly responsible for the effect to increase LDA and the Frank-Starling mechanism We also determined sites of S-glutathionylation employing mass spectrometry As with the preparations isolated from DOCA-salt hearts myofilaments incubated in GSSG had an increased Ca2+-sensitivity Sites of S-glutathionylation as determined by mass spectrometry occurred at cysteines 655 As reported previously they found the HF cells had reduced maximum tension and Ca-sensitivity By treating the myocytes with reduced GSH they were able to correct these changes They found increased S-glutathionylation of both cTnI and cMyBP-C in the HF samples compared to the donor samples Treatment with PKA failed to phosphorylate these proteins in the HF samples but worked in the donor samples there was increased titin stiffness in the HF samples that could be suppressed by treatment with PKA and GSH These data indicated a significant role for interactions of S-glutathionylation and phosphorylation in end stage human heart failure There was a correlation of cMyBP-C S-glutathionylation with increased Ca-response of tension and ATPase activity with no change in maximum or minimum values we found no evidence of actin S-glutathionylation in hearts expressing the HCM linked mutant TmE180G discussed below A main conclusion from publications from our and other laboratories is a dominant and consistent modification of sarcomere proteins by S-glutathionylation is at cMyBP-C and titin Existing evidence does indicate a need for further investigation of the potential role of actin-S-glutathionylation of integrated function of cardiac myocytes Apart from the suggestions above about use of serum levels of S-glutathionylated cMyBP-C in diagnosis and patient stratification there are several gaps in our understanding of the role of S-glutathionylation of major sarcomere proteins in cardiac physiology and pathology The unique ability of S-glutathionylation to modify Cys residues reversibly and to protect against irreversible oxidative modifications needs to be more completely understood in relation to physiological processes for example Whereas correlations with diastolic dysfunction remain a strong possibility there is evidence that this PTM may occur in a variety of cardiac disorders many of which display oxidative stress More studies on early-stage cardiac diseases are in order These studies need to integrate S-glutathionylation in the major affected proteins We think an important unexplored avenue of research is S-glutathionylation induced modulation of sarcomere length dependent activation (LDA), i.e., the Frank-Starling mechanism. Evidence of a role for titin (10, 71), cMyBP-C (56, 57), and cTnI (41, 55, 57) in altering LDA provides a rationale for this suggestion A further rationale that is unexplored is the possible modification of LDA in the oxidative stress associated with cardiac disorders demonstrating mechanical dyssynchrony Early activation of the septum associated ith late activation of the left ventricular free wall characterizes dyssynchronous heart failure (DHF) A common cause is abnormal Purkinje fiber conduction there is also evidence that DHF occurs with altered sarcomere mechano-biochemical signaling Although bi-ventricular pacing can suppress the DHF a significant number of patients do not respond to this treatment Understanding of this lack of responsiveness may involve abnormal LDA and engagement of the Frank-Starling mechanism In testing patients with non-obstructive but symptomatic HCM, Ahmed et al. (72) applied CRT (bi-ventricular pacing BiV) and tested for improvements in LV diastolic filling and exercise capacity Their approach was based on evidence of a significant incidence of dyssynchrony in HCM patients without obstructive outflow disorders The dyssynchrony manifests at rest in a maladaptive interaction between the RV and LV in diastole inducing a failure of the LV to fill properly during exercise resulting in a failure to employ the Frank-Starling mechanism there was an improvement in LV volume during exercise The authors did not investigate molecular mechanisms but did evaluate the effects of BiV on LV contractility there was no change in mechanical dyssynchrony in the study groups and no change in systolic elastance associated with BiV indicating no change in contractility with some allusions to limitation of the study the authors conclude that major mechanisms for the improvements in exercise were the effect of BiV to engage the Frank-Starling mechanism Inasmuch as length dependent sarcomere activation is the basis of the Frank-Starling mechanism this conclusion emphasizes consideration of LDA in sarcomeres with HCM-linked mutations The significance of LDA in CRT has been investigated by Niederer et al. (73) By employing a patient specific model of excitation and mechanics from the level of cellular mechanisms to heart function determined in patients before and after CRT Sensitivity of the model to various elements in cellular control mechanisms demonstrated LDA as a significant contributor to the therapeutic benefit of CRT The computations indicated a reduced effect of CRT in patients with dysfunctions in LDA A significant contribution of these findings is the idea that the Frank-Starling relation is not only important in beat-to-beat control of cardiac function but a significant mechanism in synchrony of the heartbeat Mechanical LDA and other sub-cellular mechanisms are downstream to electrical stimulation and thus dampened or amplified LDA appears to be a relatively important contributor to the efficacy of CRT This study indicates that despite the electrical effects of CRT it is critical for the heart to have robust LDA Our studies with models of HCM are relevant to these concepts. Early studies from our lab investigated the LDA of myofilaments expressing cTnT-R92Q. The data indicated a higher level of LDA in the R92Q skinned fibers compared to WT fibers (74). Other studies reported an attenuation of LDA in HCM models cTnT-R95H and cTnT-F88L (75, 76) It would be of interest to determine a role of oxidative stress and potential S-glutathionylation of sarcomere proteins in these models We think our discussions here provide a rationale for continued investigation of this powerful post-translational mechanism in sarcomere proteins The original contributions presented in this study are included in the article/supplementary material further inquiries can be directed to the corresponding author RS decided on the topic idea and after discussions with PR wrote a first draft PR read and edited the first draft and finalized the manuscript with the RS Both authors contributed to the manuscipt and approved the submitted version This work was supported by K01 HL155241 (PR) RS was a member of the Scientific Advisor Board of Cytokinetics and a consultant to MyoKardia/Bristol-Myers-Squibb The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher fluorescence resonance energy transfer; RBM20 calcium/calmodulin-dependent protein kinase II; PEVK domain Protein glutathionylation in cardiovascular diseases PubMed Abstract | CrossRef Full Text | Google Scholar S-glutathionylation in protein redox regulation Susceptibility of isolated myofibrils to in vitro glutathionylation: potential relevance to muscle functions Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity Cardiac muscle thin filament structures reveal calcium regulatory mechanism Atomic resolution probe for allostery in the regulatory thin filament Modulation of cardiac thin filament structure by phosphorylated troponin-I analyzed by protein-protein docking and molecular dynamics simulation Computational studies of the effect of the S23D/S24D troponin I mutation on cardiac troponin structural dynamics Distinct contributions of the thin and thick filaments to length-dependent activation in heart muscle Sarcomere length-dependent effects on Ca(2+)-troponin regulation in myocardium expressing compliant titin Direct visualization of myosin-binding protein C bridging myosin and actin filaments in intact muscle Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx) Modeling human cardiac thin filament structures Troponin revealed: uncovering the structure of the thin filament on-off switch in striated muscle Cardiac myosin super relaxation (SRX): a perspective on fundamental biology Structural basis of the super- and hyper-relaxed states of myosin II Novel insights into sarcomere regulatory systems control of cardiac thin filament activation The mechanics of the heart: zooming in on hypertrophic cardiomyopathy and cMyBP-C Myosin-binding protein C displaces tropomyosin to activate cardiac thin filaments and governs their speed by an independent mechanism Advances in the genetic basis and pathogenesis of sarcomere cardiomyopathies Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C) Localization of the binding site of the C-terminal domain of cardiac myosin-binding protein-C on the myosin rod Isoform-specific interaction of the myosin-binding proteins (MyBPs) with skeletal and cardiac myosin is a property of the C-terminal immunoglobulin domain Revealing the mechanism of how cardiac myosin-binding protein C N-terminal fragments sensitize thin filaments for myosin binding The C0C1 fragment of human cardiac myosin binding protein C has common binding determinants for both actin and myosin Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation Activation of myocardial contraction by the N-terminal domains of myosin binding protein-C Microscale thermophoresis suggests a new model of regulation of cardiac myosin function via interaction with cardiac myosin-binding protein C Cardiac myosin-binding protein C decorates F-actin: implications for cardiac function The myosin-binding protein C motif binds to F-actin in a phosphorylation-sensitive manner Cardiac myosin binding protein-C phosphorylation accelerates β-cardiac myosin detachment rate in mouse myocardium Fine mapping titin’s C-zone: matching cardiac myosin-binding protein C stripes with titin’s super-repeats Structure and interactions of myosin-binding protein C domain C0: cardiac-specific regulation of myosin at its neck Hypercontractile properties of cardiac muscle fibers in a knock-in mouse model of cardiac myosin-binding protein-C Myosin filament activation in the heart is tuned to the mechanical task PubMed Abstract | CrossRef Full Text | Google Scholar Myosin head orientation: a structural determinant for the frank-starling relationship Posttranslational modifications of titin from cardiac muscle: how Titin strain contributes to the frank-starling law of the heart by structural rearrangements of both thin- and thick-filament proteins Titin-truncating mutations associated with dilated cardiomyopathy alter length-dependent activation and its modulation via phosphorylation Attenuation of length dependence of calcium activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I doi: 10.1111/j.1469-7793.2000.t01-1-00541.x Cardiac myosin binding protein-C: a novel sarcomeric target for gene therapy S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure The interplay between S-glutathionylation and phosphorylation of cardiac troponin i and myosin binding protein C in end-stage human failing hearts Stress-induced protein S-glutathionylation and phosphorylation crosstalk in cardiac sarcomeric proteins - Impact on heart function Post-translational regulation of cardiac myosin binding protein-C: a graphical review Phosphorylation and function of cardiac myosin binding protein-C in health and disease Phosphorylation of cardiac myosin-binding protein-C is a critical mediator of diastolic function Site-specific phosphorylation of myosin binding protein-C coordinates thin and thick filament activation in cardiac muscle Phosphorylation switches specific for the cardiac isoform of myosin binding protein-C: a modulator of cardiac contraction Phosphorylation of troponin I and the inotropic effect of adrenaline in the perfused rabbit heart Integration of troponin I phosphorylation with cardiac regulatory networks Phosphorylation-dependent conformational transition of the cardiac specific N-extension of troponin I in cardiac troponin Is enhancing cGMP-PKG signalling a promising therapeutic target for heart failure with preserved ejection fraction Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing Cardiac myosin binding protein-C phosphorylation modulates myofilament length-dependent activation Cardiac myosin-binding protein C and troponin-I phosphorylation independently modulate myofilament length-dependent activation Tetrahydrobiopterin improves diastolic dysfunction by reversing changes in myofilament properties Novel control of cardiac myofilament response to calcium by S-glutathionylation at specific sites of myosin binding protein C Decline of contractility during ischemia-reperfusion injury: actin glutathionylation and its effect on allosteric interaction with tropomyosin Impact of actin glutathionylation on the actomyosin-S1 ATPase PubMed Abstract | CrossRef Full Text | Google Scholar Reversible S-glutathionylation of Cys 374 regulates actin filament formation by inducing structural changes in the actin molecule Myocardial infarction in mice alters sarcomeric function via post-translational protein modification S-glutathionylation of cryptic cysteines enhances titin elasticity by blocking protein folding Interventricular differences of signaling pathways-mediated regulation of cardiomyocyte function in response to high oxidative stress in the post-ischemic failing rat heart Rationale for the use of N-acetylcysteine in both prevention and adjuvant therapy of COVID-19 N-acetylcysteine reverses diastolic dysfunction and hypertrophy in familial hypertrophic cardiomyopathy Sphingosine-1-phosphate receptor modulator improves diastolic dysfunction and partially reverses atrial remodeling in a Tm-E180G mouse model linked to hypertrophic cardiomyopathy FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin Regulation of cardiac PKA signaling by cAMP and oxidants Experimentally increasing titin compliance in a novel mouse model attenuates the frank-starling mechanism but has a beneficial effect on diastole Biventricular pacemaker therapy improves exercise capacity in patients with non-obstructive hypertrophic cardiomyopathy via augmented diastolic filling on exercise Length-dependent tension in the failing heart and the efficacy of cardiac resynchronization therapy Ca(2+) activation of myofilaments from transgenic mouse hearts expressing R92Q mutant cardiac troponin T Hypertrophic cardiomyopathy mutation in cardiac troponin T (R95H) attenuates length-dependent activation in guinea pig cardiac muscle fibers Cardiomyopathy mutation (F88L) in troponin T abolishes length dependency of myofilament Ca(2+) sensitivity Usefulness of released cardiac myosin binding protein-C as a predictor of cardiovascular events Increase in cardiac myosin binding protein-C plasma levels is a sensitive and cardiac-specific biomarker of myocardial infarction Google Scholar Cardiac myosin-binding protein C as a biomarker of acute myocardial infarction Biological variation of cardiac myosin-binding protein C in healthy individuals Role of mitochondrial oxidative stress in glucose tolerance Circulating S-glutathionylated cMyBP-C as a biomarker for cardiac diastolic dysfunction Implications of the complex biology and micro-environment of cardiac sarcomeres in the use of high affinity troponin antibodies as serum biomarkers for cardiac disorders Impact of anesthesia and storage on posttranslational modifications of cardiac myofilament proteins Mechanical unfolding of cardiac myosin binding protein-C by atomic force microscopy Mechanisms of troponin release into serum in cardiac injury associated with COVID-19 patients Citation: Rosas PC and Solaro RJ (2023) Implications of S-glutathionylation of sarcomere proteins in cardiac disorders Copyright © 2023 Rosas and Solaro. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: R. John Solaro, c29sYXJvcmpAdWljLmVkdQ==, orcid.org/0000-0002-4196-0353 Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Get ready for the most awe-inspiring views of the Amalfi Coast and Mount Vesuvius MORRISTOWN — A former Newark police officer, who in 2019 fatally gunned down his estranged wife during an unbridled encounter outside their Jefferson home was sentenced Monday to 79 years behind bars With a confident and firm intonation, Judge Michael Gaus closed out the final chapter in the case of John Formisano, who after a trial that lasted just under two weeks earlier this fall was convicted by a Morris County jury of murder for the death of 37-year-old Christie Solaro-Formisano guilty of the attempted murder of her boyfriend Prosecutors say Formisano became enraged when he saw Solaro-Formisano with Simonson inside the marital home they once shared Formisano had levied a defense that he "blacked out" upon seeing the couple did not intentionally kill his wife and wound her boyfriend who held the sentencing hearing inside a 40-person-deep Morris County courtroom where tear-filled statements came from Solaro's family members condemned Formisano's attitude on Monday after the former lieutenant rambled for over a half-hour about the inadequacies of the prosecutors as well as what he called "lies" told during the trial Formisano also used his time to divulge purported character flaws and inadequacies of his deceased wife and her then-boyfriend "I just listened to what may be one of the most narcissistic statements from a defendant that anyone will ever hear in a courtroom," Gaus said who has been in the Morris County jail since his July 2019 arrest was sentenced to 50 years in prison for murder and 15 years for attempted murder under the requirement he serve at least 85% of each sentence before being eligible for parole Formisano is guaranteed to spend at least 55¼ years behind bars after which he will be well over the age of 100 He was also sentenced to 14 years on two endangering charges because his two young children were inside the home at the time of the shooting Formisano on Monday did not apologize for his actions instead stating that Solaro-Formisano "pocketed" the money he would give her to hire babysitters when the couple separated and was a physical abuser who would assault him when angered He also urged the judge to give him the "maximum" sentence since it was likely he would die in jail but reassured prosecutors he would be "seeing them in about two years anyway" because he had plans to appeal the jury verdict NJ news West Milford woman, integral part of Lindy's Lake community, dies in car crash Gaus said that although Formisano invited him to impose the maximum penalty he would not entertain Formisano's hopes that his doing so would invite "potential error" to add to his appeal Dubbing him a domestic violence abuser "without question," Gaus also noted Formisano's lack of remorse and said his words in court made it clear "he is not sorry." While tears freely flowed from those in attendance in a tension-filled Morris County courtroom Monday as a judge reflected on the actions of a defendant who appeared to show no shame it was the words from a grieving family that likely left a lasting impact exhibited a range of emotions as he spoke from a podium crying as he remembered small moments from his daughter's childhood while also outwardly expressing anger toward her former husband laughing when he recalled a time when Solaro had brought home a rabbit and hidden it from her parents But sweet moments quickly turned to anger for Wagner as he looked at Formisano — who declined to show any emotions — and called him evil stressing that calling him an "animal would be an insult to animals." who are both in therapy and suffer nightmares Much like prosecutors at trial who said Formisano's motive to kill his wife was a final act to gain control over her Debbie Wagner spoke of the internal strife her daughter was feeling in the marriage expressed fear in a text message to a friend over Formisano's control over her and she spoke to her family about how if she angered him he would withhold money and groceries from the family Solaro was a trained behavioral therapist but became a stay-at-home mom when she had her children along with the constant regret that she had not done enough to help her daughter Wiping tears as she spoke near a poster board filled with photos of her daughter and grandchildren Debbie Wagner recalled when her daughter was born the day after Christmas — a holiday season she said she can no longer enjoy "Here I stand before you a week before Christmas at what should be a happy time of the year happiness or peace in my heart during this Christmas season at what would have been my daughter's 41st birthday," Wagner said I have been permanently robbed of any true happiness with an enormous piece of my heart missing forever." but the elder wrote a letter to the court that was read by Debbie Wagner she wrote of the terror and fear she felt the night of the shooting She also said she missed the special moments she had with her mom also spoke of the lasting impacts the shooting had on the children with what should have been a happy childhood now one filled with loneliness and fear Anthony Iacullo, Formisano's attorney, confirmed he plans to appeal the jury verdict. He purposely avoided making a statement on behalf of his client because of this, but requested that the judge vacate a prior judge's order that Formisano not contact his children. Prosecutors sought a permanent bar Gaus extended the no-contact order for 180 days but said he was not in the position to make it definite Lori Comstock can be reached on Twitter: @LoriComstockNJH on Facebook: www.Facebook.com/LoriComstockNJH or by phone: 973-383-1194 The estranged wife of a Newark police officer who is accused of shooting her to death in her Jefferson home was laid to rest Monday as she was identified in her obituary posted Sunday was interred at George Washington Memorial Park Cemetery in Paramus following a funeral Mass at Our Lady Queen of Peace Church in Maywood a veteran Newark lieutenant who told authorities he "blacked out" before police say he shot his wife to death outside their Mirror Place Road home around 11:20 p.m A 40-year-old man inside the home was also wounded in the shooting was charged with first-degree murder and first-degree attempted murder in addition to possessing a weapon for an unlawful purpose and endangering the welfare of his children both of whom were home but unharmed during the incident was born in Ridgewood and lived in Garfield before moving to Jefferson in 2010 and was a former assistant behavior specialist at the Morris School District caring and loving mother to her most adored children who were her whole world," according to the obituary she was always by her children's side loving and supporting them." Solaro-Formisano's daughter was a dancer at Top Tier Dance Academy located in the unincorporated community of Stockholm in Hardyston According to a post on the academy's Facebook page beautiful woman and an extraordinary mother." Close friends of Solaro-Formisano have chosen to honor her by placing a purple ribbon on their property which is the designated color for domestic violence awareness Members of the dance academy are urged to place a purple ribbon on their house car or any other prominent location to "use this tragedy as an opportunity to raise awareness of a serious crisis in this country." have been threatened by intimate partners with firearms and one million of those alive today have been shot or shot at by their abusers according to data from the National Coalition Against Domestic Violence 928 women in New Jersey alone were killed by intimate partners Formisano was arrested hours after the incident in a parking lot in Livingston and has been suspended without pay He has been held in a psychiatric facility pending a court hearing Formisano had filed for divorce a month before the shooting and moved out of the house to take care of his mother who a friend said was dealing with health issues A GoFundMe has been set up by Formisano's former partner at the Newark Police Department Velez stated on the page the money will go into a bank account where Mike Solaro will have access since he has received temporary custody of the two children Velez has posted numerous photos of the children along with their dog getting acquainted to their new home which includes Solaro The page has garnered nearly $30,000 for the children with funds being used for relocation costs visit https://www.gofundme.com/f/formisano-children-fund Lori Comstock can also be reached on Twitter: @LoriComstockNJH on Facebook: www.Facebook.com/LoriComstockNJH or by phone: 973-383-1194 A Morris County judge will allow former Newark police officer John Formisano to establish a defense at trial that his altered mental state left him incapable of purposely shooting to death his estranged wife in 2019. Judge Noah Franzblau, in a written decision filed May 13, denied prosecutors' bids to preclude Dr. Gerard Figurelli from taking the stand, stating that he believed the defense-appointed psychologist's testimony from April 28 would help supplement a diminished capacity defense at trial "There is a suggestion in the evidence that (Formisano's) faculties were affected thereby rendering (Formisano) incapable of purposeful or knowing conduct," Franzblau wrote.  Formisano is accused of firing multiple rounds at Christine Solaro-Formisano Police said Formisano was still in his police uniform when he went inside the Mirror Place home he once shared with Solaro-Formisano found Simonson and began shooting on July 14 Figurelli opined that Formisano had an "acute dissociative reaction" when he learned another man was inside his marital bedroom. Figurelli who evaluated the former lieutenant multiple times, said he believed Formisano when confronted with the upsetting discovery was unable to control his emotional reaction when he began shooting.  Preexisting diagnoses of major depressive disorder and post-traumatic stress disorder left Formisano particularly vulnerable to experiencing such a reaction Prosecutors sought to keep the expert's findings away from a jury stating during the April hearing Figurelli's findings were not backed by any factual or evidentiary support and were not accepted within the scientific community They also contended that Figurelli failed to connect Formisano's mental conditions to his mental state at the time of the crime Related: Newark cop charged with wife's murder will reject plea deal with 40-year prison sentence Police licensing: Legislation to create licensing for NJ police officers proposed by Gov. Phil Murphy Formisano's attorney Anthony Iacullo could not mention the defense to a jury Formisano is facing charges of murder and attempted murder Should a jury find his state of mind was altered as a result of a mental defect Figurelli supported his conclusions by including a transcript of an interview he had with Formisano after the shooting — details that have not been released until now that forms the basis for a diminished capacity defense who was living with his mother after he filed for divorce from his wife said the night of the shooting he was leaving work and noticed that his daughter had left her glasses in his car so he headed to the Jefferson home to drop them off so he walked into the home and up the stairs "Everything came at once," Formisano recalled to Figurelli "She was in her bathrobe; I'm hearing movement in my bedroom my bedroom door is closed; My children are in their bedroom There had been an agreement she would not have another man in the home according to the report. Solaro-Formisano allegedly accused Formisano of setting up cameras in the house suggesting he came over because he knew a man was there Solaro-Formisano yelled "Call the police" and his daughter screamed for her mom Formisano said he "blacked out," with his "spirit" outside his body and a view of his gun shooting he was getting a "bird's eye view" from the grass outside and then an image of Solaro-Formisano falling "I don't get any sound," he told the psychologist Figurelli opined that Formisano's inability to recall the actual shooting was consistent with someone diagnosed with PTSD and is known medically as psycho-traumatic amnesia Memory loss from traumatic events can either be partial or total and is believed to be a result of a disruption between emotion and the part of the brain that controls memory The area of the brain that controls emotion is experienced as a state of "unreality" or "surreal," he added.  agrees Formisano experienced a brief episode of derealization during the shooting Formisano, a 24-year veteran of the Newark Police Department, spent 10 months at Ann Klein Forensic Center in Trenton before his transfer to the Morris County jail. He rejected a plea deal of 40 years in prison in 2020.  Formisano will have a pretrial conference in early June. Lori Comstock can be reached on Twitter: @LoriComstockNJH, on Facebook: www.Facebook.com/LoriComstockNJH or by phone: 973-383-1194. As daylight faded into dusk, about 80 people gathered at the municipal complex gazebo last Thursday night for a candlelight vigil to remember the light of Christine Solaro, 37, who was allegedly fatally shot by estranged husband Acting Newark Police Lt. John Formisano, 49, on July 14. They came together in their collective grief to pray, to reflect and to begin the healing process, as the small rural community struggles to process the tragic events of three weeks ago. “It’s been a difficult few weeks,” vigil organizer Angela Lamendola said. “Jefferson has been shaken to its core by recent events, ending in the passing of Christie Solaro.” Lamendola added that the community doesn’t think of itself as that type of place. “Jefferson is a sleepy town. My friends and I jokingly and lovingly refer to it as Mayberry,” she said. “Stuff like this doesn’t happen here. Only it does happen here. It did happen here.” Lighting a purple candle in front of a portrait of Solaro, Lamendola said that purple is the color designated for domestic violence and that she was surprised to learn how pervasive a problem it is in Jefferson Township. Since Solaro’s death, Lamendola said she has learned that the town is in the top third in Morris County in terms of domestic violence occurrences. According to county domestic violence statistics filed with the state Attorney General’s Office, Morris County had 604 total original investigations in 2018, 254 of which were pending or inactive at the beginning of the year. Seventy-nine defendants in original investigations were criminally charged through accusation. A breakdown by municipality was not available. “Now is the time for healing, now is the time for hope,” she said. “For those of you who knew Christie, as I did, I am so very sorry for your loss and the anguish you are coping with right now. God knows I’m feeling it too.” Whether it was meeting up for coffee or for their daughters’ playdates, or sending internet memes via group chat, Lamendola said that Solaro was a daily fixture in her life. “It’s a void I felt immediately and feel immensely,” she said of Solaro’s death. Solaro was a dedicated mother, Lamendola said, who fought for her children and was fiercely protective of them. “Those kids were her whole world,” she said. “There was nothing she wouldn’t have done for them.” A great friend who made everything better just by being there, Solaro was there both to make you laugh and pick you up when you were down. “Christie had a light within her that shined so bright it was a beacon of joy,” Lamendola said. “This candle I’ve lit up here represents that light. I will now use it to light my vigil candle.” “We’ll continue to pass this light, from person to person, until we are all basking in the glow of Christie’s light,” she said. Whether strangers, acquaintances, neighbors or friends, those in attendance passed the light of the candles from one to the next until all were lit. A prayer of hope was then read by Rev. Ellen Mearns Bechtold, pastor of Milton United Methodist Church. Following Bechtold’s prayer, Mayor Eric Wilsusen read a poem aloud called “Feel No Guilt in Laughter,” as the glowing candles illuminated the somber faces of those in attendance. “The community of Jefferson Township mourns Christie’s passing, but we also celebrate her life,” he said, before reading the poem. Recognizing that it might be more difficult in light of the circumstances, Lamendola sang “I Have This Hope,” in honor of the woman she called a friend. At the conclusion of Lamendola’s song, people were invited to share memories of Solaro with those gathered. Holding back tears, Cathy Guida, of Morris Plains, said she and Christie had a friendship that went back to the ninth grade. “We’ve been through a lot together and she was the most amazing person you would ever want to meet,” she said. “There was a little bit of time there where we kind of drifted apart, but we found our way back and I am just so grateful for that time that we had together.” Township resident Danielle Yager spoke about Solaro’s great kindness to her when she became pregnant with her children and how she was coping with her loss. “The other day, when we had that big storm, I looked up and there was the most vibrant rainbow I have ever seen, and I knew that she was with us and that everything was going to be okay,” she said, pausing for a moment to regain her composure. Copyright © 2022 ALM Media Properties, LLC. "[C]atastrophically injured plaintiffs like our client face further injury or even death if they don't get trial listings. There is no greater urgency than a situation like this," said plaintiffs lawyer Benjamin Present. With civil and matrimonial trials still suspended in some parts of New Jersey because of the shortage of judges some lawyers say the inability to resolve cases is causing hardship for their clients a plaintiff's lawyer is seeking an exemption from the civil trial moratorium claiming his request for a speedy trial is a matter of life and death National Law Journal The Recorder Law.com Brugh Lower of Gibbons has entered an appearance for industrial equipment supplier Devco Corporation in a pending trademark infringement lawsuit accusing the defendant of selling knock-off Graco products 18 in New Jersey District Court by Rivkin Radler on behalf of Graco Inc Read More Yalowitz of Arnold & Porter Kaye Scholer have entered their appearances for Hanaco Venture Capital and its executives 24 in New York Southern District Court by Zell accuses the defendants of negligently and fraudulently managing the plaintiff's $1 million investment Read More Attorneys from A&O Shearman has stepped in as defense counsel for Toronto-Dominion Bank and other defendants in a pending securities class action 11 in New York Southern District Court by Bleichmar Fonti & Auld accuses the defendants of concealing the bank's 'pervasive' deficiencies in regards to its compliance with the Bank Secrecy Act and the quality of its anti-money laundering controls Read More a Pennsylvania company providing shared communications infrastructure Wolf of Gordon Rees Scully Mansukhani to fend off a pending breach-of-contract lawsuit 25 in Michigan Eastern District Court by Hooper Hathaway PC on behalf of The Town Residences LLC accuses Crown Castle of failing to transfer approximately $30,000 in utility payments from T-Mobile in breach of a roof-top lease and assignment agreement Read More Schwartz of McCarter & English have stepped in as defense counsel to Electrolux Home Products Inc 26 in New York Eastern District Court by Poulos Lopiccolo PC and Nagel Rice LLP on behalf of David Stern alleges that the defendant's refrigerators’ drawers and shelving repeatedly break and fall apart within months after purchase Read More Already have an account? Sign In aggravated by the legacy of multiple strokes and what was surely chronic traumatic encephalopathy(CTE) Philip grew up in Pittsburgh and earned a BA in history from Yale University ending as a major with a primary specialty in intelligence He earned his Ph.D.in history from Georgetown University an independent op-ed columnist and a staff writer for Insight on the News back when the Times was a respected newspaper with a point of view “In Re” for the defunct Washington Law & Politics about “lighter side of cancer” for the Jerusalem Post most recently Yom Kippur Party Goods (John Hunt / O Books 2010) and completed several unpublished works including a novel of the foundation of the State of Israel A nationally-respected and unusually prescient defense analyst Philip predicted an imminent major terrorist strike in the spring of 2001 he became one of America’s first conservatives to oppose the Iraq War in a futile attempt to prevent an utterly wasteful war of choice he was invited to leave the semi-prominent Discovery Institute in Seattle Philip then broke entirely with conservatism afternearly forty years a story told in Take Back the Right: How the Neocons and the Religious Right Have Betrayed the Conservative Movement (Avalon/Carroll & Graf The Coming Draft: The Crisis in Our Military and Why Selective Service Is Wrong (Random House/Presidio 2006) was favorably reviewed by and named one of the 100 best books of the year by the New York Times Such is the price of being a decade ahead of the times a price Philip paid willingly for the sake of all Americans and their Republic Philip took seriously the words of the forgotten father of American conservatism “‘Politics is the art of the possible,’ the conservative says: he thinks of political policies as intended to preserve order Philip recognized that while the past has value we can use he believed it should be permitted no say over our lives And he had a deep and abiding respect for the equal human worth of every woman and man and of the equal civic value of every American as well as exceptional physical and mental toughness his sister-friends Marianne Cochrane Cramer Mcdonald Virginia Cochrane Torbert and Patricia Cochrane Gross A member of that herd of exceptionally valiant cattle Not signed up for Daily Kos yet? Create a free account 2019 at 1:15 pm ET.css-79elbk{position:relative;}Christie Solaro-Formisano loved her two children and made a career of helping other children as a behavior specialist NJ — A Jefferson woman shot and killed by her estranged police officer husband was a "beautiful caring and loving mother," family members wrote in an obituary remembering her Christie Solaro-Formisano, 37, was killed last weekend when police say her estranged husband, Newark police Lt. John Formisano, shot her several times. The couple share two children, Ryan and Rachel, whom family members describe as Solaro-Formisano's "whole world." swim meets or numerous other activities she was always by her children's side loving and supporting them," her obituary reads and she will be forever loved and sorely missed by all of her family and friends." Solaro-Formisano was born in Ridgewood and lived in Garfield for most of her life Her love of children went beyond just her own two: Solaro-Formisano previously worked as an Assistant Behavior Specialist at the Morris School District Memorial services for Solaro-Formisano were held on Monday morning the Solaro family asks that donations be made to a fundraiser to benefit the two children Since their mother's death, Ryan and Rachel have been living with Christie's brother, Mike Solaro. Solaro has been appointed as the children's legal guardian. Eventually, the children's pet dog, Ellie, will also live with Solaro. Read More: Support For Family After NJ Cop's Alleged Murder Of Wife The fund for the children has raised nearly $30,000 towards a $50,000 goal in less than a week a retired police officer who worked with Formisano in Newark the account will only be accessible by Solaro Velez said the fundraiser was born out of a duty to take care of Ryan and Rachel."This money is being raised for one reason and one reason only - Rachel and Ryan’s benefit Not one red cent is going to [Formisano's] mother or to any other entity," Velez said John Formisano was taken into custody early last Monday morning in a parking lot in Livingston, several hours after he is accused of shooting Solaro-Formisano dead in the home the couple used to share. Read More:'Black Out:' Chilling Details In NJ Cop's Alleged Murder Of Wife Formisano told investigators that he'd gone over to the couple's 1 Mirror Place home in the Oak Ridge section of Jefferson Township late Sunday night to drop off a pair of glasses for one of the couples' children When he began to suspect that Solaro-Formisano had a man in the bedroom he began to "black out," Formisano told police but that he remembered firing his gun multiple times killing Solaro-Formisano and injuring her boyfriend The couple was in the process of a difficult divorce Velez provided this information about how the children will be able to access the funds: Get more local news delivered straight to your inbox. Sign up for free Patch newsletters and alerts. Volume 10 - 2019 | https://doi.org/10.3389/fphys.2019.00478 This article is part of the Research TopicProbing the cardiac arm of the baroreflex and complementary branchesView all 12 articles Interests about the fine underpinnings of cardiovascular beat-by-beat variability have historical roots various aspects of the relationships between arterial pressure and heart period were taken as a proxy of the baroreflex in physiology and medicine stimulating the interest of investigators in several interconnected scientific fields Studies of the overall system facilitated the emergence of a simplified negative (vagal) feedback model of the baroreflex and overshadowed the simultaneous interaction with excitatory sympathetic positive-feedback mechanisms that would better suit the model of a “paired antagonistic (parasympathetic/sympathetic) innervation of the internal organs.” From the bioengineering side the simplicity of obtaining the series of subsequent RR intervals stimulated the analysis of beat-by-beat variations providing a multitude of heart rate variability (HRV) indices considered as proxies of the underlying sympatho-vagal balance and participating to the management of several important clinical conditions used in an integrated manner and controlling for age and gender biases might help shed new light on the relationship between cardiac baroreflex assessed by the frequency domain index α and the HRV indices with the varying of systolic arterial pressure (SAP) levels The focus is also on a novel unitary Autonomic Nervous System Index (ANSI) built as a synthesis of HRV considering its three most informative proxies [RR and the rest-stand difference in the normalized power of low-frequency (LF) variability component] Data from a relatively large set of healthy subjects (n = 1154) with a broad range of SAP [from normal (nNt = 778) to elevated (nHt = 232)] show that α and ANSI significantly correlate overall (r = 0.523 and that this correlation is lower in hypertensives (r = 0.444 p < 0.001) and higher in pre-hypertensives (r = 0.618 p < 0.001) than in normotensives (r = 0.5 That suggests the existence of curvilinear “umbrella” patterns that might better describe the effects of the SAP states on the relationships between baroreflex and HRV non-parametric and resampling statistical techniques we give empirical support to this study hypothesis and show that the pre-hypertensive group results at the apex/bottom in most of the studied trends now surpassing 23,000 in the Medline database witness beyond doubt the growing interest on HRV as a de facto standard Even a simple cursory look at available literature, it appears that HRV may spark interest for different reasons, i.e., biological and technical, alone or combined, risking to favor debates about semantics rather than substance (Brown, 2017): but even at maximal stimulation some level of vagal activity remains amplitude and frequency codes should both be considered in the modeling of RR V it is possible to reduce the number of significant proxies and minimize redundancy From a clinical perspective, it is crucial to recall that HRV (particularly its time domain proxies) provides sensitive markers of prognosis in several conditions, particularly in coronary artery disease, predicting mortality in post-myocardial infarction (Huikuri and Stein, 2013) It should also be considered that explicit acceptance of a mixed neural model of the autonomic (!) innervation could clear large fraction of the existing inconsistencies about HRV interpretation This aspect is beyond the aim of the present study We then assess how SAP levels affect these relationships according to the study hypothesis that non-normotensive states could induce changes in the strength and significance of this kind of relationships Results are displayed through convenient graphical tools that aim at providing valuable insights into the examined trends Data for this observational, cross-sectional study, which is part of an ongoing series of investigations, focus on the use of autonomic indices in cardiovascular prevention. They refer to a population of 1154 ambulant subjects, who visited our outpatient Exercise Medicine Clinic for reasons varying from a health check-up to cardiovascular prevention (Lucini and Pagani, 2012) for chronic conditions inclusive of hypertension (considering untreated non-smokers individuals within the 17–86 years age range) The protocol of the study followed the principles of the Declaration of Helsinki and Title 45 The project was approved by the Independent Ethics Committee of IRCCS Humanitas Clinical Institute (Rozzano All subjects provided informed consent to participate Definition of the variables (ANS proxies plus ANSI) employed in the studya Frequency and percentage distributions of the participants to the study within the three SAP groups and further subdivision in seven SAP intervals almost 84% of Nt subjects are individuals with less than or equal to 49 years of age in both female (55.98% out of 1154) and male (44.02% out of 1154) groups this percentage reduces to 64.3% within females and 62.5% within males while in the Ht group to 35.3% within females and 56.9% within males Distribution of the 1154 participants to the study by gender and classes of age within the three SAP groups For the same arguments extensively discussed in Lucini et al. (2018) and with the same methodology therein presented we accomplished the comparability among the SAP groups by statistically transforming the original ANS proxies in such a way they were free of age and gender effects we fitted a two-way full ANOVA model for each ANS proxy regarded as the dependent variable and classes of age and gender as the independent variables through their main effects and interaction the resulting ANOVA residuals (given for each proxy by the difference between observed and predicted values) were referred to as adjusted ANS proxies and accordingly used in place of the original ANS proxies in all the subsequent statistical analyses Following Lucini et al. (2002), our study hypothesis was that potential connections, observed over the total set of subjects, between the baroreflex gain (as measured by the α index) and the other ANS proxies could differ in strength, direction, or statistical significance depending on the SAP group. Focusing specifically on the linear relation (or correlation) between the α index and the other variables listed in Table 1 we were interested in assessing whether the preHt group could represent a sort of transition state from Nt to Ht group in which the correlations between the α index and the other ANS proxies plus ANSI could even strengthen This research question mostly arose from our experience in analyzing this type data where frequently we had observed non-monotonic (or curvilinear) effects of SAP groups on the correlations involving the α index there is a medium correlation of α and ANSI overall (r = 0.523 p < 0.001) as well as in the Nt group (r = 0.5 but the correlation tends to weaken in the Ht group (r = 0.444 p < 0.001) and strengthens in the preHt group (r = 0.618 the correlation of α and RR LFnu is weakly negative overall (r = -0.281 p < 0.001) and in the Nt group (r = -0.261 but it is not significantly different from zero in the Ht group (r = -0.033 All that seems then to evidence the presence of either monotonic- or curvilinear-type effects of the SAP groups on the correlations between the α index and the other variables Scatter plots of the α index against the ANS proxies and ANSI over the whole set of subjects The Pearson correlation coefficient r between the α index and each of the other ANS proxies plus ANSI is written above each panel together with the p-value of the standard procedure for testing: H0: ρ = 0 against H1: ρ ≠ 0 the regression line (with parameters estimated by the ordinary least-squares method) is depicted in red It is worth stressing that these regression lines are used only as graphical references for better visualization of the spread of the point clouds the α index is not regarded as the dependent variable of a regression model In the light of the above issues, correlations between the α index and the other variables listed in Table 1 were inspected both over the whole set of subjects and within the SAP groups by using the ANS proxies adjusted for age and gender effects and the following statistical methods (for which further methodological details are given in Figure 2): The bootstrap algorithm and the statistical methodology for non-parametric inference (2) having decided to introduce no assumption for the data distribution as a resampling technique we applied the non-parametric stratified balanced bootstrap to generate B = 5000 bootstrap replicates from the original data 5000 new datasets each of size equal to n = 1154 subjects with p = 16 variables (the adjusted ANS proxies plus ANSI and the classification variable given by the SAP group membership) (a) by balancing, over the whole set of the nB bootstrap observations generated, the same subject was randomly sampled (with repetition) for exactly B times, but he/she might not be present in each of the B bootstrap replicates or might be present twice or more in any bootstrap replicate. In such a way, simulation errors were reduced considerably in comparison with the ordinary bootstrap procedure (Davison et al., 1986); The adjusted ANS proxies and ANSI were recomputed on each of the B = 5000 bootstrap replicates obtained the WINcorr coefficient was computed on each replicate and for every comparison between the adjusted α index and the other ANS proxies plus ANSI both over the whole set of subjects and within the SAP groups we obtained 5000 values of the WINcorr coefficient (i.e. a bootstrap distribution) for each type of examination and each pairwise comparison involving the α index As a synthesis of the multitude of these bootstrap distributions we used the median rather than the mean for reducing the influence of potential anomalous values on subsequent analysis results; both on the overall set of subjects and within the SAP groups on the medians of the bootstrap WINcorr coefficients according to the following three approaches: (a) with the aim of providing plausible ranges of variation for every correlation coefficient involving the α index, non-parametric 95% bootstrap confidence intervals were computed through the BCa (i.e., “bias-corrected and accelerated” intervals, given as adjusted bootstrap percentiles) method (DiCiccio and Efron, 1996; Davison and Hinkley, 1997); (b) to test the null hypothesis of zero correlation coefficients of the α index and the other variables, a bootstrap permutation test (Hall and Wilson, 1991; Davison and Hinkley, 1997) was applied at the 0.05 nominal significance level; (c) in line with the study hypothesis above described, we applied the Hettmansperger–Norton trend test (Hettmansperger and Norton, 1987) to verify the hypothesis, at the 0.05 nominal significance level, of no effect of the SAP groups on the correlation coefficients concerning the α index against the following two sets of patterned alternatives (explicitly presented in Figure 2): (i) the SAP groups have increasing/decreasing effects on the strength of the correlations (so-called monotonic ordered alternatives (ii) the SAP groups have concave- or convex-shape effects on the strength of the correlations (so-called umbrella alternatives similar to quadratic or curvilinear contrasts) With the aim of simplifying the interpretations we will present most of the findings obtained by the bootstrap procedure and the non-parametric inference through a synoptic figure and several graphs such as the correlation plot and the ridgeline plot this last graph turned out to be a powerful tool for visualization of the SAP group effects and their trend patterns consistently with the Hettmansperger–Norton procedure Descriptive data concerning the original ANS proxies and ANSI are given in Table 4 as means and standard deviations computed over the whole set of subjects and within the three SAP groups A further inspection based on the box plots of the distributions of the (both original and adjusted) ANS proxies and ANSI within the SAP groups is reported in SM and the α index present the highest mean values in the Nt group and the smallest ones in the Ht group and SAP LFa have the highest mean values in the Ht group The preHt group has the largest mean values for RR LFnu and RR LF/HF it is worth observing that its mean values decrease from the Nt group to the Ht group thus proving its sensitivity to the different ANS states observed under the various SAP conditions Descriptive data (mean and standard deviation) of the ANS proxies and ANSI within the SAP groups and over the whole set of subjects Regarding the bootstrap analysis, Figure 3 displays panels of box plots of the within-groups bootstrap distributions of the WINcorr coefficients (with γ = 0.1) computed for every pairwise comparison involving the adjusted α index with the other adjusted ANS proxies along with ANSI (Figure 2) the umbrella pattern appears in its entire evidence in line with our study hypothesis in the first panel concerning the WINcorr coefficient between the adjusted α and HR it can be seen a convex effect of the SAP condition on the strength of the negative correlation the negative linear relationship between α and HR (the higher the HR values the smaller the α values) tends to strengthen in the preHt group in the last panel concerning the WINcorr coefficient between the adjusted α and ANSI the positive linear relationship between α and ANSI (the higher the ANSI values the higher the α values) tends to strengthen Box plots of the bootstrap distributions of the WINcorr coefficients (with γ = 0.1) of the adjusted α index and the adjusted ANS proxies along with ANSI computed within the SAP groups over the B = 5000 bootstrap replicates to higher correlation coefficients (roughly +0.2) between α and RR LFa as well as RR HFa (in the preHt group especially) and to lower coefficients (nearly -0.1) between α and RR LF/HF as well as SAP LFa although the sign of both Pearson and WINcorr coefficients does not change across the groups especially moving from the Nt group to the Ht group the strength of the linear relations with the α index reduces in the Ht group the bootstrap confidence intervals present fairly small widths in the whole set of subjects (0.096 on average) as well as in the Nt group (0.121 on average) thus suggesting that the strength of correlation in the various comparisons is appraised with high stability the confidence intervals result wider in the preHt (0.270 on average) and Ht groups (0.240 on average) thus reflecting a greater internal heterogeneity of these two groups that is bolstered by their smaller sizes than the Nt group Non-parametric 95% bootstrap confidence intervals for the medians of the WINcorr coefficients (B = 5000 bootstrap replicates γ = 0.1) between the adjusted α index and ANS proxies plus ANSI over the whole set of subjects and within the SAP groups Figure 4 displays the correlation plot of the medians of the WINcorr coefficients computed over the whole set of subjects and within the SAP groups along with the results of the bootstrap permutation procedure for testing the hypotheses of null correlation coefficients between the α index and each of the other variables Corresponding p-values are reported in the legend cells containing non-significant coefficients are marked with an X symbol the hypothesis of the absence of a linear relation involving the α index is accepted at the 0.05 level: in the Nt group All this seems to support our starting conjecture about the existence of SAP group effects on the pairwise relationships between α and the other considered variables Correlation plot of the WINcorr coefficients (with γ = 0.1) between the adjusted α index and ANS proxies plus ANSI over the whole set of subjects and within the SAP groups A cross placed on an ellipse in the cells indicates a non-significant result at the 0.05 nominal significance level achieved by the bootstrap permutation test (B = 5000 replicates) The corresponding p-values are given in the following table: A cell is colored in light yellow in the presence of a non-significant result the preHt group has a particular role because the α index proves to have a strong magnitude of positive correlation with RR HFa (95% CI: [0.610 These interpretations can be visualized better through the ridgeline plots in Figure 6 the relative position of the smoothed density curves that interpolate the bootstrap distributions of the within-groups WINcorr coefficients Ridgeline plots of the bootstrap distributions of the WINcorr coefficients (with γ = 0.1) of the adjusted α index and the adjusted ANS proxies plus ANSI within the SAP groups Blue density curves denote distributions of positive correlation values while red density curves distributions of negative correlation values First row of panels: presence of ordered monotonic effects (increasing or decreasing) of the SAP groups Second–third rows of panels: presence of umbrella (concave-shape) effects of the SAP groups Fourth–fifth rows of panels: presence of umbrella (convex-shape) effects of the SAP groups By using non-parametric and robust statistical procedures combined in the perspective of a multitude of simulated replications of the study we give empirical support to the conjecture that there exist specific pressure states in which the relationship between the cardiac baroreflex and ANS proxies can strengthen or weaken We have turned this conjecture into practical terms by introducing the trend analysis of the SAP group effects on the correlations between the α index and each of the ANS proxies along with ANSI after adjustment for the potential biases by age and gender We have focused on both ordered monotonic trends increasing or decreasing effects moving from the Nt group to the Ht group concave- or convex-shape effects concerning which the preHt group is regarded as an intermediate transition pressure condition a delicate issue that we had to face concerned the fact that the results found should not strictly depend on the adopted statistical methodology we are not able yet to advance plausible explanations of such an observed phenomenon In order to avoid potential straining caused by the applied statistical methods we conducted an extensive preliminary study using alternative techniques to make the conclusions as far as possible untied from the specific analysis approach empirical support to the existence of the patterned trends related to the SAP group memberships such as the ones presented the study and the statistical analyses we addressed should be more appropriately considered as a first exploratory phase toward a broader investigation that should also take into account the role of other individual characteristics (e.g. which we guess might affect the results found here to some extent the statistical approach we adopted to meet the objectives of the study was designed in order to overcome several drawbacks inherent in the type of data under analysis (a) the different age-by-gender composition of the whole set of subjects which led us to introduce the adjusted ANS proxies (while ANSI is free of age and gender effects by construction); (b) the presence of a small subset of outlying subjects concerning certain, but not all, variables, a problem that required us to use the WINcorr coefficient as a robust measure of the linear relationship between the α index and each of the other variables listed in Table 1; (c) the necessity of providing a more general value to the statistical analyses without having the possibility of replicating the data collection on new sets of subjects a fact that we overcame by turning to the bootstrap resampling technique; (d) the improperness of the normality assumption for the bootstrap distributions of the WINcorr coefficients for which reason we preferred to apply a non-parametric approach for both the bootstrap procedure and the inference we decided to carry out the analyses between the α index and the ANS proxies according to a bivariate pairwise correlated with different strength and sign and that a multivariate approach could have taken into account these intertwined connections at best this would have required us to use methods of synthesis of the data having as disadvantages the facts of introducing additional margins of error in the analyses as well as making the reading of the findings less clear from a clinical point of view that profit from the analogous power of information hidden in the baroreflex as predictive tool This study was carried out in accordance with the recommendations of the Independent Ethics Committee of IRCCS Humanitas Clinical Institute (Rozzano Italy) with written informed consent from all subjects All subjects gave written informed consent in accordance with the Declaration of Helsinki The general protocol was approved by the Independent Ethics Committee of IRCCS Humanitas Clinical Institute (Rozzano and DL contributed to conception and design of the study MM contributed to data acquisition and database organization NS designed the statistical methodological approach NS and MP wrote the first draft of the manuscript All authors wrote sections of the manuscript and contributed to manuscript revision The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fphys.2019.00478/full#supplementary-material Power spectrum analysis of heart rate fluctuation: a quantitative probe of beat-to-beat cardiovascular control Heartscope: a software tool addressing autonomic nervous system regulation CrossRef Full Text | Google Scholar The central autonomic network: functional organization CrossRef Full Text | Google Scholar The LF/HF ratio does not accurately measure cardiac sympatho-vagal balance CrossRef Full Text | Google Scholar Baroreceptor reflex control of heart rate: a predictor of sudden cardiac death CrossRef Full Text | Google Scholar Diminished baroreflex sensitivity in high blood pressure CrossRef Full Text | Google Scholar Canty, A., and Ripley, B. (2017). Boot: Bootstrap R (S-Plus) Functions. R Package Version 1.3-20. Available at: https://CRAN.R-project.org/package=boot Google Scholar Google Scholar CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar Exercise training reduces resting heart rate via downregulation of the funny channel HCN4 Sympathovagal balance: a critical appraisal CrossRef Full Text | Google Scholar Defective cardiac parasympathetic control in patients with heart disease Editorial (2004) CrossRef Full Text | Google Scholar CBMS-NSF Regional Conference Series in Applied Mathematics Google Scholar The value of cardiovascular autonomic function tests: 10 years experience in diabetes Google Scholar Two guidelines for bootstrap hypothesis testing CrossRef Full Text | Google Scholar Happ, M., Zimmermann, G., Bathke, A. C., and Brunner, E. (2018). Pseudorank: Pseudo-Ranks. R Package Version 0.3.8. Available at: https://CRAN.R-project.org/package=pseudorank Hess, W. R. (2014). Nobel Lecture: The Central Control of the Activity of Internal Organs. Nobelprize.org.Nobel Media AB. Available at: http://www.nobelprize.org/nobel_prizes/medicine/laureates/1949/hess-lecture.html Google Scholar Tests for patterned alternatives in k-sample problems CrossRef Full Text | Google Scholar Google Scholar Heart rate variability in risk stratification of cardiac patients Heart rate variability: why do spectral analysis CrossRef Full Text | Google Scholar Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators Google Scholar Correlation between baroreflex gain and 24-h indices of heart rate variability Heart rate variability to monitor performance in elite athletes: criticalities and avoidable pitfalls From stress to functional syndromes: an internist’s point of view Autonomic differentiation map: a novel statistical tool for interpretation of heart rate variability Mair, P., and Wilcox, R. (2018). WRS2: Wilcox Robust Estimation and Testing. R Package Version 0.10-0. Available at: https://CRAN.R-project.org/package=WRS2 Google Scholar Emerging excitatory role of cardiovascular sympathetic afferents in pathophysiological conditions Cardiovascular neural regulation explored in the frequency domain CrossRef Full Text | Google Scholar Brain stem reticular formation and activation of the EEG CrossRef Full Text | Google Scholar The evolution of systolic blood pressure as a strong predictor of cardiovascular risk and the effectiveness of fixed-dose ARB/CCB combinations in lowering levels of this preferential target Potential US Population Impact of the 2017 ACC/AHA High Blood Pressure Guideline Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog Interpreting oscillations of muscle sympathetic nerve activity and heart rate variability A positive feedback sympathetic pressor reflex during stretch of the thoracic aorta in conscious dogs Benchmarking heart rate variability to overcome sex-related bias Changes in autonomic regulation induced by physical training in mild hypertension The yin and yang of cardiac autonomic control: vago-sympathetic interactions revisited R Core Team (2018). R: A Language and Environment for Statistical Computing. Vienna: R Foundation for Statistical Computing. Available at: https://www.R-project.org/ Google Scholar A composite autonomic index as unitary metric for heart rate variability: a proof of concept A cardiocardiac sympathovagal reflex in the cat Sprint Research Group (2015) A randomized trial of intensive versus standard blood-pressure control Cardiac parasympathetic outflow during dynamic exercise in humans estimated from power spectral analysis of P–P interval variability Task Force of the European Society of Cardiology and the North American Society of Pacing Heart-rate variability: standards of measurements physiological interpretation and clinical use Diabetic cardiovascular autonomic neuropathy Wei, T., and Simko, V. (2017). R package “corrplot”: Visualization of a Correlation Matrix (Version 0.84). Available at: https://CRAN.R-project.org/package=corrplot Google Scholar Autonomic neural control of heart rate during dynamic exercise: revisited ggplot2: Elegant Graphics for Data Analysis Google Scholar Introduction to Robust Estimation and Hypothesis Testing Google Scholar Wilke, C. O. (2018). ggridges: Ridgeline Plots in “ggplot2”. R Package Version 0.5.1. Available at: https://CRAN.R-project.org/package=ggridges Google Scholar Prehabilitation: preparing patients for surgery PubMed Abstract | CrossRef Full Text | Google Scholar Pagani M and Lucini D (2019) Cardiac Baroreflex and Statistics: An Interdisciplinary Approach in Hypertension Copyright © 2019 Solaro, Malacarne, Pagani and Lucini. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Daniela Lucini, ZGFuaWVsYS5sdWNpbmlAdW5pbWkuaXQ= MORRISTOWN — In a solemn day of testimony that introduced medical findings and distressing photos of a Jefferson woman purportedly killed at the hands of her estranged husband prosecutors concluded their case by questioning a Sussex County man who found himself at the center of a marital dispute — and inescapably in harm's way Timothy Simonson, of Andover Township, had only been dating Christie Solaro-Formisano, 37, for about a month when on July 14, 2019, her estranged husband, John Formisano, then a Newark police lieutenant, stormed through the front door and up the stairs of the Mirror Place home where he once lived and began shooting Formisano admitted to police that he "lost it" when he found Simonson in his bedroom and fired his police-issued weapon striking his wife first before turning the gun on Simonson Formisano then fatally shot his fleeing wife near a neighbor's front steps Formisano's attorneys have not denied that their client opened fire they say Formisano's mental state left him incapable of doing it on purpose arguing that point throughout his trial in state Superior Court in Morristown where he stands accused of murder and attempted murder He faces a possible life sentence if convicted which marked the conclusion of evidence in the prosecution's case began as any other new-age dating story: Simonson found Solaro-Formisano on the popular dating website Match.com Simonson said he was under the impression she was separated and going through a divorce so the couple took it slowly: He saw her a few more times before finally meeting her two young children he texted Solaro-Formisano and went to her house He recalled Solaro-Formisano getting out of bed around 11:15 p.m. he's here," before putting on a bathrobe and heading downstairs call 911," and then seconds later he heard gunshots so he put on his shirt and tried to escape through a window but couldn't get it open He was near the bedroom closet when Formisano "barged" into the room and shot him several times "It was like a hot fire poker going into you," Simonson said of the bullets piercing his skin Simonson said Formisano yelled something at him before he fell to the ground and Formisano left Simonson said he believed he was going to die: "I knew I had been shot a bunch and figured it was the end but noticed it had been damaged by a bullet He threw the phone aside and used his arms to drag himself down the stairs and into the living room where he grabbed Solaro-Formisano's phone and made contact with an emergency dispatcher NJ newsHurricane Ian won't hit NJ like Ida, but remnants could bring some needed rain Simonson suffered at least six gunshot wounds: two to his left thigh reiterated several times to the jury that Formisano and Solaro-Formisano were still married at the time of the shooting and pointed to a collage of photos on the bedroom wall that purportedly had Formisano in them He also pointed to Simonson's need to get out of bed and into his clothing quickly upon hearing Formisano was at the home "You're deciding that it's better to get dressed than to lay naked in my client's bedroom," Iacullo asked because I thought there was going to be a fight and I didn't want to fight naked." The defense began its case Tuesday afternoon by introducing Dr. Gerard Figurelli, a forensic psychologist whom prosecutors tried in April to bar from ever appearing at trial. The doctor previously opined that Formisano's altered mental state caused him to go through a severe dissociative reaction when he found his wife with another man in their marital bedroom His actions were "unconscious and out of control," he testified in April The argument lays out a defense for diminished capacity allowing them potentially to lessen the murder charge to Prosecutors on Monday gave the jury a peek into the moments leading up to and during the shooting from varying perspectives including video and audio showing the final moments of Formisano-Solaro's life The jury watched Formisano on video around 10:30 p.m the night of the shooting walking to his white Mazda sedan and driving away from the parking lot of the Newark Police Department's 4th Precinct neighbors were awakened by the sound of gunshots whose house is opposite the Formisano home said he heard a woman scream around 11:20 p.m. but a pair of children's binoculars proved unsuccessful as he tried to see through the blackness of the night say he watched as a man in dark clothing walked to a white sedan — one he recognized as belonging to Formisano — and leave after the shooting ceased He noted that the vehicle was not in the driveway of the Mirror Place home; rather the sedan was parked near a tree on the other side of the property along adjacent White Rock Boulevard The 16-member jury on Monday watched as video from a Ring doorbell camera affixed to the adjacent neighbor's home captured a frantic Solaro-Formisano as she sought refuge from her estranged husband The bloodied woman can be seen holding her left side as she climbs the four steps to the neighbor's home and rings the doorbell Please!" Solaro-Formisano is heard yelling before she runs off to the next home NJ newsA fat budget, money in the bank and credit upgrades. NJ is seeing a financial turnaround Phone records introduced by a Morris County Prosecutor's Office detective show the estranged couple had a fractured separation with Formisano seemingly unable to control his emotions with his wife In text messages about two weeks before the shooting Formisano tells Solaro-Formisano he is "hurt" that she is dating and pleads with her to keep her dates away from the children unless they speak first He admits he has trouble "letting go" and tells her he loves her "You can't understand the pain I feel," he writes in a message before pleading that "all I ask is to not connect anyone to our kids and our home." Solaro-Formisano does not appear to reciprocate love for Formisano and instead focuses on the harm he allegedly causes the couple's two young children by failing to provide for them financially when he gets "angry" with her She also expressed disdain for his "childish" behavior "Don't threaten us by showing up whenever you want." "My happiness comes from having freedom from you," she texts Formisano the night before the shooting on Facebook: www.Facebook.com/LoriComstockNJH or by phone: 973-383-1194 Jury selection has begun for the trial of the former Newark police officer accused of fatally shooting his wife and seriously wounding her boyfriend in Jefferson in July 2019 The Morris County Prosecutor's Office confirmed that jury selection began on Monday for John Formisano's trial but said there was no trial date set yet The former police lieutenant, who worked for the Newark Police Department for 24 years, was still in his work uniform when he allegedly killed his 37-year-old wife, Christie Solaro-Formisano. She was found dead on July 14 Formisano surrendered during a motor vehicle stop in Livingston The alleged murder weapon was found in his vehicle Police said he had taken off his police uniform stashed his cellphone and E-ZPass reader under a dumpster and removed his car's front license plate after the shooting was shot seven times and required emergency surgery he said in a 2020 lawsuit against Formisano and the Police Department that last year was paused pending the resolution of Formisano's criminal case Solaro-Formisano was struck multiple times as she tried to flee to a neighbor's home where Formisano allegedly fired several more rounds Formisano rejected the prosecution's final plea offer as it was firm about giving him 40 years in prison for a guilty plea for the shooting of Solaro-Formisano and Simonson in February He faces up to life in prison plus 70 years should he be convicted He was found mentally competent to stand trial He was admitted to the Ann Klein Forensic Center for treatment after the shooting and his attorneys will be able to argue that his altered mental state left him incapable of purposefully shooting Solaro-Formisano to death who was living with his mother after filing for divorce from his wife said that on the night of the shooting he was leaving work noticed that his daughter had left her glasses in his car and drove to the home to return them so he entered the house and walked up the stairs where he encountered his estranged wife coming out of the bedroom Formisano's young children were home at the time of the shooting and a judge ruled in August that he was not allowed to have contact with them leading up to the trial A Newark police lieutenant has been convicted of murdering his estranged wife, as well as trying to kill her new boyfriend John Formisano was found guilty by a Morris County Superior Court jury after an eight-day trial and roughly two days of deliberations Morris County Prosecutor Robert Carroll confirmed late on Tuesday The 52-year-old Formisano had repeatedly rejected plea deal offers of 40 years in prison, as reported by NJ.com and now faces up to life in prison when sentenced Formisano has remained suspended from the police force without pay Newark would be formalizing his termination an attorney for the city confirmed to New Jersey 101.5 saying it was “a process which is not instantaneous.” a 37-year-old mother of two young children died on a neighbor's front steps around 11:30 p.m She had already been shot by Formisano and had run from her home at 1 Mirror Lane in Jefferson for help but was shot again and killed two houses away Formisano was also found guilty of the attempted murder of Timothy Simonson — who was shot multiple times in the home’s master bedroom The off-duty police officer used his service weapon to fire at least 15 shots at the couple Both of the Formisano’s young children were found Simonson testified that he had only been dating the victim for about a month when her ex showed up and opened fire, as previously reported by the Daily Record Formisano had fled the scene and was found around 2 a.m His gun was recovered from the trunk of his vehicle He was also found guilty on Monday of two unlawful weapons possession offenses two counts of endangering the welfare of a child and one count each of hindering apprehension and official misconduct A sentencing date was still to be set by the court —Formisano would remain in custody until that time neighbors said that the gunshots had sounded like fireworks Erin Vogt is a reporter and anchor for New Jersey 101.5. You can reach her at erin.vogt@townsquaremedia.com Click here to contact an editor about feedback or a correction for this story. Gallery Credit: Madison Troyer & Zack Abrams John Formisano was found guilty by a Morris County Superior Court jury on all counts, stemming from the brutal 2019 shooting death of Christie Solaro Formisano, a 37-year-old mother of two.\nRead More A Newark police lieutenant has been convicted of murdering his estranged wife, as well as trying to kill her new boyfriend The 52-year-old Formisano had repeatedly rejected plea deal offers of 40 years in prison, as reported by NJ.com Formisano has remained suspended from the police force without pay Simonson testified that he had only been dating the victim for about a month when her ex showed up and opened fire, as previously reported by the Daily Record Erin Vogt is a reporter and anchor for New Jersey 101.5. You can reach her at erin.vogt@townsquaremedia.com Click here to contact an editor about feedback or a correction for this story. - Percent of residents with paid hunting licenses: 0.7%\r\n- Total paid hunting license holders: 267,170\r\n- Total hunting license permits and stamps: 991,897\r\n- Gross cost of all hunting licenses: $21,107,452 Over the past 50 years, the number of hunting licenses in California has been on a rapid decline, falling 70% from more than 760,000 in the 1970s to under 268,000 in 2020—even as the state’s population has skyrocketed are why California has the fewest number of hunting licenses in the nation - 2021 worldwide retail sales: $8.89B\r\n- Number of U.S recent college graduates Ryan Cohen and Michael Day launched their online pet supply retailer Catering to millennials who treated their pets like children rather than animals the company differentiated itself by offering 24/7 customer service the duo sold their brand to PetSmart for a record-setting $3.35 billion An online fundraiser set up for the children of a Newark police lieutenant charged with the shooting death of his estranged wife has collected $17,000 in just two days Christie Solaro, 37, the children's mother, was shot and killed Sunday in her Jefferson home, and her estranged husband, John Formisano The GoFundMe page was launched by Miko Velez and has a goal of $20,000 to benefit Rachel and Ryan Formisano-Solaro who are being cared for at an undisclosed location.  "Tragedy struck the Formisano-Solaro family this week who has been charged with her passing," Velez posted "They are with family and are surrounded by the most important thing they can have John Formisano was charged with first-degree murder after police said he shot Solaro and a male house guest who was off duty at the time of the shooting, was taken to the psychiatric unit at St Clare’s hospital in Boonton Township for evaluation "Rachel and Ryan are wonderful children who are blessed to have a strong network of family and friends to help care for them," Velez wrote "Everyone is doing all they can do for the children's transition to this new life considering the circumstances." Velez said he is caring for the family's dog "Last night we were able to get access to the house and stuffed as many black bags with the children's clothing medication and kitchen utensils we could," Velez wrote We are raising money to help offset the costs of relocating the children and providing a financial foundation for their future needs." Stay cool: Morristown extends cooling stations through weekend Committee rule: Rockaway Township Council misses deadline to select new member William Westhoven: 973-917-9242; wwesthoven@dailyrecord.com troops will have been in Afghanistan longer than the Soviets were The United States has been engaged in combat in Afghanistan and Iraq longer than in any previous war Not factoring in the increase in soldiers going to Afghanistan that President Barack Obama recently announced some 220,000 American women have engaged in combat operations in Afghanistan and Iraq servicemen and servicewomen have served together in situations and for durations that have never existed in previous conflicts the feared "disasters" did not materialize no waves of "get me out of here" pregnancies our men and women in uniform have behaved as military professionals women are fighting on all fronts of the war on terrorism and are regularly engaged in combat operations there are still barriers to their work and promotion a senior fellow at the Center for a New American Security and former Washington Post reporter noted in a recent article that one of the chief barriers to fully utilizing servicewomen in counterinsurgency operations in Afghanistan is not Afghan but American attitudes Women are thought to make up about half the Afghan population and female soldiers and Marines have reportedly had more success gaining access to Afghan women than male troops have had Rather than assuming that we should not impose our values on Afghans why not consider the possibility that Afghans of both sexes might be tired of barbarism and could be delighted to see civilization backed by armed men — and women Perhaps they would take up arms to that end An internal Marine assessment of its "female engagement teams" that has been discussed in recent weeks on military Web sites quoted an Afghan village elder as saying Navy Secretary Ray Mabus announced in October that he and Adm were close to finalizing plans for the integration of women into the submarine fleet as early as 2011 There has been no feminist agitation for bringing women into the submarine fleet organized political feminism as we remember it from the 1970s through the 1990s committed suicide on Sept when it refused to call women to the colors in this odd war we are fighting against Islamic fundamentalism Nor has internal agitation based on limited manpower been reported Is it possible we are seeing the beginnings of a top-down campaign to end the 1994 policy that has excluded women from assignment to direct we are likely to hear much chatter soon about sex on submarines and alternate use of limited bathroom and berthing space on notoriously cramped vessels Common sense and courtesy should go a long way toward resolving such issues And why should anyone object that those are unreasonable expectations of sailors No one who cannot deal in a civilized manner with female comrades-in-arms and shipmates needs access to a rifle These concerns are at the core of the issue of dropping the remaining restrictions against servicewomen (and don't tell" policy banning openly gay and lesbian troops from the services) Twenty-five percent of military jobs are not open to women and those jobs lead disproportionately to higher command it's true that few men become commandant of the Marine Corps or sergeant major of the Army need not aspire to the pinnacle of their profession Combat is the core of the profession of arms The military has an absolute right to expect servicewomen to engage in combat as female Americans have been doing in Iraq and Afghanistan for years It should be a matter of personal honor and institutional integrity for the military's senior (male) leadership to say: "Servicewomen long ago earned the right to be treated as our sisters-in-arms we urgently petition Congress to drop all remaining restrictions against them As for the men within our ranks who disapprove of this: The man who hurts or disrespects our sisters-in-arms excuses their rapes and harassers or collaborates with their assailants is not our brother." American women and gays have a stake in the survival of our republic and the military will continue to need to draw on their strength It is time the military acknowledged them and welcomed them into the profession of arms a West Point graduate and former Army officer wrote 'Porcelain on Steel: Women of West Point's Long Gray Line.' Solaro wrote 'Women in the Line of Fire: What You Should Know About Women in the Military,' based on her research during embedded tours with troops in Iraq and Afghanistan 2019 at 3:32 pm ET.css-79elbk{position:relative;}Lt John Formisano is accused of killing his estranged wife NJ — A Newark police officer accused of killing his estranged wife and seriously injuring her boyfriend told investigators that he “blacked out” upon realizing the two were inside a bedroom together in the estranged couple’s Jefferson Township home a 24-year veteran of the Newark Police Department said he did remember shooting Christine Formisano who was using the name Christie Solaro at the time of her death but that he was in a “blacked out state,” according to the affidavit of probable cause Formisano told investigators that he’d gone over to the couple’s 1 Mirror Place home in the Oak Ridge section of Jefferson Township late Sunday night to drop off a pair of glasses for one of the couples’ children When he began to suspect that Solaro had a man in the bedroom he began to “black out,” Formisano told police told police that Formisano and Solaro spoke on the phone shortly before her death; just after the call Solaro said she saw a flashlight outside the home and warned T.S were in the bedroom when Solaro spotted Formisano outside the home Solaro left the bedroom and locked it behind her running to 3 and 5 Mirror Place to try and get inside a neighbor’s house A witness told police that she saw Formisano shoot Solaro outside of 5 Mirror Place where her body was eventually found by police was conscious but bleeding when the Morris County Sheriff’s Emergency Response Team found him He was taken to the Morristown Medical Center trauma unit with injuries to his thigh Formisano was arrested in a parking lot in Livingston around 2 a.m Police say they found a handgun inside his car trunk but that Formisano threw his cell phone away Formisano agreed to speak to investigators, and police say he exhibited suicidal behavior or threatened self-injury at that point. According to NJ.com Formisano is being held at a psychiatric unit at St told investigators he was aware that the Formisanos were in the process of a divorce when he began dating Christine Formisano John Formisano purchased the 1 Mirror Way home by himself in 2007 according to property records; Christie Solaro is listed on mortgage documents from 2012 who are both under 10 years old and were not named in the affidavit and were “located nearby” at the time of the slaying Formisano faces two counts of second degree endangering the welfare of a child The children were taken from the home by Morris County Sheriff’s officers a family friend wrote on a fundraiser set up for them “Last night we were able to get access to the house and stuffed as many black bags with the children's clothing, toys, medication and kitchen utensils we could. They are with family and are surrounded by the most important thing they can have, love,” Mike Velez, a partner on the force with Formisano, wrote on a GoFundMe Any funds raised will be put into a bank account dedicated to offsetting the costs of raising the children Members of the law enforcement community also extended their thoughts for the children “I pray for Christine Formisano who tragically lost her life during this incident as well as the recovery of the survivors and healing for their families who have suffered a terrible loss,” Sheriff James Gannon said in a statement “I am very proud of the work of all the Morris County law enforcement agencies in their response and ultimate criminal investigation of this very tragic event.” Formisano has been suspended from the Newark Police Department without pay In addition to two counts of endangering the welfare of a child and two counts of possession of a weapon for an unlawful purpose."The Newark Public Safety Department is deeply saddened by the family tragedy involving Newark Police Lt is for the couple's two children who have lost their mother and for the family of the victim Formisano's colleagues in our police division were shocked by the news of the shooting and we recognize it this is a tragedy beyond comprehension for all involved." Editor's note: If you or someone you know is struggling with domestic abuse, you can call the National Domestic Violence Hotline at 1−800−799−7233 or TTY 1−800−787−3224 Get more local news delivered straight to your inbox. Sign up for free Patch newsletters and alerts. Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here The young children of a former Newark police officer who were inside their Jefferson home when their father fired a spray of bullets at their mom and her boyfriend in summer 2019 will have no contact with their father leading up to the murder trial concluded the 11-year-old daughter and 6-year-old son of John Formisano and Christie Solaro-Formisano are "impressionable based on their tender ages" and may be susceptible to direct or indirect suggestion to provide favorable testimony for their father The decision came following a motion by prosecutors to bar Formisano any contact with his children, including through third parties, through the conclusion of his trial Prosecutors plan to call the children to the stand as witnesses believing the issue should have been in the hands of a judge in the state Superior Court's Family Division who could better evaluate the evidence and determine the best interests of the children But Formisano will abide by the judge's order Franzblau said while parental rights are often addressed in the family division he had the right to temporarily restrict Formisano's communication with his children due to his obligation to ensure a fair trial and protect the children as victims had argued Formisano's communications with his children could cause them fear intimidation or hesitation in cooperating with the prosecution of their father who have been living with Solaro-Formisano's family have had "limited" contact with their father since he was jailed in Morris County in 2019: The children have received "periodic" letters from their father but have not seen him in person faces up to life in prison plus 70 years if convicted in the July 14 2019 shooting death of his estranged wife and the attempted murder of her boyfriend Formisano was still in uniform when he entered their once-shared Mirror Place home to found Simonson in his bedroom Crime:Morristown man sentenced in fatal train station brick attack Tax bill rise:Parsippany’s average tax bill to rise after council OKs contentious hike Simonson was shot seven times and required emergency surgery; Solaro-Formisano was hit several times as she attempted to flee to a neighbor's home where Formisano purportedly fired more rounds Formisano has not professed his innocence to the crimes charged, instead asserting he is not responsible for his actions as a result of his diminished mental capacity in his July 13 written decision obtained by the Daily Record there is no dispute that the children are "victims" of their father who were 8 and 3 years old at the time of the shooting "were inside the home during this incident and they were located nearby where the firearm was discharged." The children were also left alone in the house with a critically injured Simonson after Formisano fled the scene Iacullo previously stated he planned to file a motion to exclude the children as witnesses at trial but said Wednesday he does not plan to take any further action Two additional motions are expected to be heard this week who was living with his mother after he had filed for divorce from his wife said the night of the shooting he was leaving work and noticed his daughter left her glasses in his car and drove to the home to return them Franzblau in May said he would allow Formisano's attorneys establish a defense that his altered state left him incapable of purposely shooting his wife rather a jury could consider a lesser change a date that now appears to be set in stone Franzblau will not preside over the trial; state Superior Court Judge Michael Gaus Edit: This story have been updated to clarify that John Formisano has sent letters to his children from the Morris County jail where he remains pending trial Exceptionally heavy rainfall in northern Italy’s Emilia-Romagna region last week led to a series of floods and landslides that have killed at least 15 people and forced more than 40,000 from their homes but cleanup efforts have just begun as residents and volunteers clear out mud and recover what can be salvaged We want to hear what you think about this article. Submit a letter to the editor or write to letters@theatlantic.com A collection of winning and honored images from this year’s nature-photo competition A collection of amazing recent images made with the Hubble Space Telescope Mourners of Pope Francis gathered at the Vatican scenes from the the second weekend of Coachella 2025 and landscapes of the Earth’s arctic and subarctic regions The Taboo actor narrates this conflict-packed wildlife documentary like an old-school thesp Reading bedtime stories has clearly mellowed him baffling viewers as formidably butch top-hatted adventurer Jack Delaney in the BBC drama Taboo while others calculated that the 98 pig-like grunts Hardy emitted in the first seven episodes were not so much signs of an apparently pre-verbal role The only pig-like grunts you’ll hear in Predators come from the prey that realise all too late that like the innocent insects eaten by Matt Hancock their fate is to have their last moments supply bloody entertainment for allegedly higher life forms like a latter-day Ross Kemp or Vinnie Jones he has a masculinist CV to lend credibility to the script he brings something more likably fey to his task He’s neither as comically stentorian as Matt Berry nor as whisperingly mannered as David Attenborough but rather redolent of some old-school English thespian as he sets the scene a notorious brotherhood of cheetahs,” he intones Kudos to Hardy – I never had to turn on the subtitles which is more than you can say about most of television’s mumblecore output My favourite speech comes when our two protagonists expect to have to fight an interloping male “The rival male is a female and despite the frosty welcome Females only mate with males who are fit and strong.” Nature is not only red in tooth and claw We know there are gay penguins; when are gay cheetahs going to get representation Director Will Benson has assembled footage from drones Jeep-mounted rigs and other devices to trace a narrative arc that uncannily echoes the recent series of Gangs of London Two young male cheetahs (think Ron and Reggie Kray) are trying to establish their dominance in a well lush manor in the Serengeti But a quartet of interloping youngers – whom Hardy calls the Solaro brothers – are muscling in on the boys’ turf power and to mate with any ovulating females in the vicinity Hardy tells us that drought conditions have made the savannah into a tinder box readily consumed by fire And so it comes to pass: a sequence of flaming red skies backlit by the setting sun The fires consume or displace the cheetahs’ prey and as the smoke wafts hundreds of miles north makes a mega-herd of at least 1 million wildebeest plus thousands of zebras and hartebeests who sniff the breeze doubtfully and pause on their migration south to the once nutritious grasslands this mega-herd is a drug shipment on which the feuding mobsters depend are never going to outpace the fastest land mammals and we see a predating hyena at the back of the shot Neither camera crew nor park rangers intervene they are followed by the migrating mega-herd none of which presumably realise that they may soon be the cheetahs’ main course the turf war with the Solaro brothers reaches a truce and the jeopardy is over Free weekly newsletterGet the best TV reviews news and features in your inbox every Monday I learn surprising things from Hardy’s narration a single cheetah litter can have multiple fathers The lone female mates with both of our brothers and their genetic material thereby gets mingled I also learn that thanks to the climate crisis and farmers killing the predators that menace their livestock there are now only about 7,000 cheetahs left in the world but with their numbers falling and nature documentary output increasing it can only be a matter of time before every one has had its moment in the camera’s crosshairs 2019 at 2:57 pm ET.css-79elbk{position:relative;}Christie Solaro-Formisano NJ — A Ridgewood native was remembered as a "caring and loving mother" by her family in the days following her death Christie Solaro-Formisano, 37, was killed July 14 when police said her estranged husband Solaro-Formisano's family said in her obituary that the couple's two children swim meets or numerous other activities she was always by her children's side loving and supporting them," the obituary read Solaro-Formisano was born in Ridgewood and lived in Garfield before moving to Jefferson Township in 2010 She was a graduate of William Paterson University Children were her life as a former behavior specialist at the Morris School District She "dedicated her life to being around them," her family said More than $29,000 had been donated to her children on a GoFundMe page created by Miko Velez a retired police officer who worked with Formisano "Rachel and Ryan are wonderful children who are blessed to have a strong network of family and friends to help care for them Everyone is doing all they can do for the children's transition to this new life considering the circumstances," Velez said on the GoFundMe page The fundraiser grew out of an oath Velez made with Formisano Rachel and Ryan are my niece and nephew," Velez said "Johnny and I made a promise to each other more than 20 years ago that should anything happen to us The money will help defray the cost of relocating the kids and providing a "financial foundation" for their future needs "These children have a rough road ahead," Velez said "We are raising money to help offset the costs of relocating the children A funeral Mass for Solaro-Formisano was Sunday She was interred at George Washington Memorial Park Cemetery in Paramus Solaro-Formisano is survived by her parents; Debbie Wagner and Mark Solaro; brothers Michael and his wife Susan; mother-in-law Carol Formisano; nieces Henrik; step-father Dale Wagner; and many cousins and friends Get more local news delivered straight to your inbox. 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Volume 8 - 2020 | https://doi.org/10.3389/feart.2020.574032 To understand the dynamics of magmatic systems one must first seek to characterize the time-dependent behavior of magma storage and ascent we do this through a combination of the Crystal System Approach and careful study of Fe-Mg interdiffusion in orthopyroxene This allows us to trace the pre-eruptive dynamics of magma plumbing systems We apply this novel approach on two large silicic eruptions (about 3–5 km3 DRE/eruption) that occurred in the central part of Dominica Island (Lesser Antilles Arc): the eruptions of Layou (∼51 ka) from Morne Diablotins and Roseau (∼33 ka) from Morne Trois Pitons-Micotrin two magmatic environments (MEs) are identified on the basis of orthopyroxene composition with a dominant reverse-zoning pattern from 50 to 54 to 54–59 mol% enstatite (En) three MEs are observed as represented by three populations of pyroxenes: En47-51 The normal-zoning pathway from En51-53 to En47-51 is significantly registered by crystals interpreted as convective mixing in a zoned reservoir The reverse-zoning pathway from En47-51 to En51-53 and also En53-58 is also significantly present supporting the mixing within the zoned reservoir but also suggesting mixing with a hotter magma possibly stored in another part of a sub-volcanic mush The crystal and glass compositions (melt inclusion and matrix glass) from both studied eruptions suggest heating and mixing between different magma pockets located within the mush that were the dominant process for mobilizing eruptible magma we constrain the associated pre-eruptive timescales by modeling the diffusive relaxation of Fe-Mg chemical gradients that originated within the zonation of the same orthopyroxene crystals Diffusion modeling was considered along the b-axis of 66 zoned orthopyroxene crystals for these two eruptions at a magmatic temperature of 850 ± 25°C we propose that the Layou and the Roseau magma reservoirs were rejuvenated and heated by ∼25–50°C about 10 years prior to eruption by the injection of an underplating creating the observed dominant reverse-zoning patterns of the erupted orthopyroxenes We thus have evidence that silicic mush can be re-mobilized over timescales of decades prior to eruption as previously suggested for Santorini and Taupo volcanoes How magma is stored at depth and how magma bodies assemble prior to eruption are two questions that are still widely debated. The architecture and associated dynamics of magma plumbing systems for silicic volcanoes have been in the last decade envisaged as transcrustal magma systems (Cashman et al., 2017) following the pioneering work of Bachmann and Bergantz (2003) Dominica volcanic activity thus offers the unique opportunity to investigate the magma dynamics in the plumbing system prior to repeated large silicic eruptions FIGURE 1. Dominica and studied ignimbritic eruptions. (A) Lesser Antilles arc, with Dominica in the central part of the arc. (B) Dominica and location of the sampled outcrops (stars) for Layou and Roseau ignimbrites, after Boudon et al. (2017) Red: deposits from Morne Trois Pitons–Micotrin eruptive center with dark red deposits corresponding to Roseau eruption Blue: deposits from Morne Diablotins eruptive center with dark blue deposits corresponding to Layou eruption (E) Layou pyroclastic density current deposit (F) Roseau pyroclastic density current deposit The results are discussed for their implications in terms of the more general framework of the magma plumbing system architecture and dynamics beneath Dominica we assess the rates of silicic magma rejuvenation prior to voluminous explosive volcanic eruptions The Lesser Antilles Arc results from the westward subduction of the North-South American plates beneath the Caribbean plate, at an average rate of 2 cm/yr (Wadge, 1984). The volcanic arc is 850 km long, and extends from the island of Saba in the north to Grenada in the south, with an eastward convexity. Dominica is located in the central part of the arc (Figure 1) Amphiboles in Layou are ferri-magnesio-hornblende with Mg# [Mg/(Mg + Fetot)] ranging from 0.52 to 0.60 Clinopyroxenes are augites with Mg# ranging from 0.48 to 0.71 Fe-Ti oxides are titanomagnetites (Mag71–75; Mag = magnetite mol%) and ilmenites (Ilm87; Ilm = ilmenite Phase equilibrium experiments starting from glasses of Roseau and Layou bulk compositions have been performed in an internally-heated pressure vessel, spanning a temperature range of ∼800–900°C, a pressure range of 200–400 MPa (under water saturation and under-saturation), and fixed oxygen fugacity of ≈ NNO +0.6 (NNO = Nickel- Nickel oxide buffer) (Solaro et al., 2019) By experimentally reproducing the natural melt and phenocryst rim compositions the magma storage conditions have been determined to be close to a pressure of ∼400 MPa a temperature of 850 ± 25°C with 7–8 wt% H2O dissolved in melt These parameters will be used for the diffusion modeling below Studied pumices and crystals come from the field campaigns performed previously for chronostratigraphic, melt inclusions and experimental petrological studies (Boudon et al., 2017; Balcone-Boissard et al., 2018; Solaro et al., 2019). The samples consist of white, homogeneous pumice clasts collected from the basal Plinian fallout deposits of Layou and Roseau (Figures 1C,D) Whole rock samples were gently crushed to liberate crystals and sieved 701 for Roseau) crystals were separated by hand-picking under binocular microscope and mounted in epoxy resin Orthopyroxenes were oriented during mounting to obtain b-c sections needed for diffusion modeling along the b-axis of crystals The method (Figures 2A–E) is based on the modeling as a diffusion profile of the core-to-rim traverse (Figure 2E) obtained by coupling a high analytical resolution profile by Electron Probe Microanalyses (Figure 2D) and a high spatial resolution profile by SEM (Figure 2C), following the methodology developed by Allan et al. (2013) and Couperthwaite et al. (2020) By using a library of profiles calculated for particular values of compositional contrast the appropriate curve shape to apply to a natural crystal can be selected from the library based upon compositional data and then scaled in width to solve for time The scaling factor needed is a simple expression of crystal composition the diffusivity used for the library profiles the diffusivity in the crystal and the ratio of diffusion timescales in the library and the timescale of the crystal As the scaling factor can be determined from data the timescale for the crystal can be simply solved as the only unknown The internal consistency of timescales obtained by this modeling method is tested by modeling several profiles on the same core-rim boundary of the same crystal and verifying for the acquisition of comparable timescales the pre-exponential factor (D0) and the activation energy (Ea) all have a logarithmic effect on final calculated timescales such that the final uncertainties are not Gaussian in time but asymmetric with larger error bar on the long-time side and smaller error bar on the short-time side with uncertainties approaching Gaussian behavior in log-time Here we have used the diffusion coefficient resulting from the parameterization of Ganguly and Tazzoli (1994) In summary, all modeled profiles and timescales have been here calculated for a fixed temperature of 850°C (±25°C) based upon the experimental work of Solaro et al. (2019) on these magma compositions. This yields diffusivities of the order of D ∼10–20 m2 s−1 (Ganguly and Tazzoli, 1994) without dependence of the diffusivity on oxygen fugacity The initial condition is considered to be a step-wise profile (i.e. instantaneous growth at a fixed composition followed by diffusional relaxation of the interface) which yields maximum timescales if all broadening occurs via diffusion Compositional profiles for these eruptions have been interpreted as pure diffusion profiles with no or limited recorded growth, i.e., considering profiles as due purely to diffusion. This constrains maximum timescales, because if the profiles have a growth component, the required timescale is shortened. The fitted profiles have features typical of diffusive character—smooth compositional variation of sigmoid shape (Supplementary Figure 2) Oscillations can be seen toward the rim but are minor in amplitude (±0.2 mol% or less) and could plausibly be attributed to noise growth-dominant profiles would display linear trends or curves on graphs of composition vs which would not be congruent nor consistent with a diffusion sigmoid calculated for the given initial compositional contrast The CSA technique has been successfully applied to the study of Etna, in order to define the main active magmatic environments (ME) prior eruption from crystal compositional zoning, their connections (by heating, decompression, mixing, mingling, crystal settling, etc) and the pre-eruptive processes occurring at depth (Kahl et al., 2011; Kahl et al., 2015) a ME is not necessarily a single batch of magma but may be different part of the same reservoir at depth a variety of ME were described based on olivine-melt equilibria and their occurrence with time We applied this method to orthopyroxenes (opx) that show variations in major-element composition (Enstatite content XEn) that can be related to changes in the magmatic system These changes can lead to either reverse zoning typically associated with higher temperatures typically associated with cooler and shallower environments The compositions of unzoned, single zoned and multiple zoned opx along rim-to-rim or core-to-rim traverses allow us to identify compositional plateaus (En mol% plateaus) (Supplementary Table S3) Compositional plateaus have been here defined as regions of the profiles with a minimum length of ∼15 µm (respect to 315–500 µm wide crystals) within which the En content of the crystal shows a constant value with accepted variability of ±0.5 mol% The composition of each plateau is then calculated as an average of all values defining the plateau The occurrence of plateaus can be interpreted as a result of crystal growth in different with residence times in each environment long enough to be recorded by crystal growth but also short enough that the compositional gradient has not been erased by diffusional equilibration The repetitive occurrence of plateaus indicates that compositional zoning observed in a given crystal has not been produced by pure fractionation during growth but by subsequent and fast changes during crystal growth in response to a change from one ME to another or physically transferring a crystal to a different melt assuming that crystal growth occurred sequentially from core to rim cores represent the first ME recorded by crystals while outer rims represent the last ME Analysis of compositional plateaus from core to rim allows us to track either movements of crystals and their carrying melts between different ME or modification of storage conditions by external processes (heating etc.) through the plumbing system until eruption This procedure has to be repeated on all analyzed crystals in order to define crystal populations and the frequently-travelled crystal transfer pathways This method allows a simple graphical representation that avoids much of the difficulties of combining and interpreting diverse and complicated zoning patterns between crystals of the same sample Here we applied this approach to opx to highlight magma transfers and the magnitudes of these transfers at depth between the different ME This approach is based on the recognition of the diversity of opx composition interpreted as ME changes we can identify the disrupting events at depth responsible for magma remobilization up to eruption That is also why a ME does not necessarily correspond to a physical lens of magma within the crust; this will be discussed hereafter A total of 1,452 opx were analyzed for the two eruptions (701 for Roseau, 751 for Layou), including their textural features and chemical compositions (Figure 3; Table 1; Supplementary Tables S2, S3) Selected SEM images illustrating the opx zonations for Roseau (A: normal; B: reverse; C: multiple reverse+normal) and Layou (D: normal; E: reverse; F: multiple Frequency histograms of the zoned and unzoned orthopyroxene compositions in Roseau (left side) and Layou (right side) expressed in terms of En (mol%) (G,J) unzoned crystals in grey; (H,K) cores of zoned crystals in blue for Layou and red for Roseau; (I in dashed blue for Layou and dashed red for Roseau Unzoned orthopyroxene compositions: single point analyses in the crystal core Core and rim composition: averaged plateau compositions of the zoned crystals with a minimum length of ∼15 μm Statistic repartition of zonations in opx from Layou and Roseau eruption Opx are separated in the 315–500 µm fraction the unzoned populations are a good proxy for the cores of the zoned populations for both eruptions and the rims represent dynamic events that happen subsequently Selected melt inclusion compositions as a function of host-orthopyroxene composition (En mol%) Core-to-rim composition profiles were obtained and modeled for 44 selected zoned opx (21 for Roseau and 24 for Layou). Layou crystals included both normal- and reverse-zoned examples while only reverse-zoned crystals were studied for Roseau (given the dominance of reversely-zoned crystals in this eruption). Examples of data interpreted as diffusion profiles for Layou and Roseau are shown in Figure 5 As the purpose here is to constrain the last pre-eruptive processes only the last change in composition - the outermost zone excluding quench - has been used for timescale determination in each case Examples of two modeled diffusion profiles for Roseau (A) and Layou (B) Red/blue line on each Back-Scattered Electron (BSE) image (left) indicates the profile position [Electron Probe Microanalyses (EPMA) full profile] on the respective orthopyroxene (Roseau Diffusion profiles (right) are reported as Mg# [Mg/(Mg + Fetot)] as a function of the distance from the center of the profile (in µm) Red rhombs: EPMA and BSE greyscale intercalibrated data; black line: diffusion model The initial conditions are given by the dashed line (staircase profile) Timescale estimate from Fe-Mg interdiffusion modelling in orthopyroxenes Frequency histogram of Fe-Mg interdiffusion timescales modelled at 850°C for the main core-rim boundary of (A) Roseau opx and (C) Layou opx; (B) and (D) individual ages and their absolute uncertainties based on the propagation of a temperature uncertainty of ±25°C for (B) Roseau and (D) Layou The inset graphs inside (B) and (D) represent selected individual ages from the peak in interdiffusion ages TABLE 2. Timescales estimates for Layou and Roseau eruption. Sample labeling refers to the stratigraphy of Boudon et al. (2017) with DOM41a3 for Layou and DOM60d1a for Roseau Timescales are given in year with the detail in uncertainty (σ+ and σ−) The type of zonation (simple or multiple) and the position within the multiple zoned opx is given The corresponding plateaus in En content and the ME changes are detailed ∼400 MPa (depth of ∼16 km considering a local rock density of 2.45 g/cm3) a melt H2O content of ∼7–8 wt% (i.e. slightly H2O-undersaturated conditions) and an oxygen fugacity close to NNO +0.6 Such stable conditions of the main magma body are highlighted by a population of ∼85% of unzoned opx crystals in the 315–500 μm range Here we discuss for both eruptions what the other ∼15% of zoned opx can tell us about the last magmatic events that triggered the eruption the En content of opx is less dependent on pressure an increase or a decrease in En content may in some cases be interpreted as a heating or a cooling event when magmas of different compositions or temperatures are mixing FIGURE 7. A variant Crystal Systems Analysis (CSA) diagram dedicated to opx, after the methodology of Kahl et al. (2015) demonstrating the direction and nature of sequential crystal zones of the opx from the Roseau (A) and Layou (B) eruptions Each crystal is represented by a single arrow Black arrows denote simple zoning and red arrows denote multiple zoning The size of the magmatic environment boxes (ME1 to ME3 with subscript L for Layou and R for Roseau) are proportional to the number of unzoned crystals (grey) of the given composition (XEn) plus the number of zoned crystals (white) with cores of the given composition Inset: Localization within the crust of the mush zone studied here The color of the crystal is linked to magma temperature from “cold” environment in blue to “hot” one in red with intermediate temperature in orange; relative temperature estimates are on the basis of opx composition Initial stage for (A) Roseau and (C) Layou The dynamic model proposed on the basis of opx for (B) Roseau and (D) Layou this would imply that the timescales calculated for both processes are too short for accurate discrimination by the method or that both processes are related The injection of a new batch of hot magma may be responsible for the magma convection within the intruded reservoir The complexity of the pre-eruptive magma dynamics for the Layou eruption confirms the hypothesis of a system heterogeneous in temperature, with parts of the magma stored at lower temperature (allowing quartz crystallization; Solaro et al., 2019) the CSA results suggest more direct paths and fewer magma transfers in the case of Roseau magmatic system Various studies have already used the Fe-Mg interdiffusion chronometer in opx to retrieve timescales of magma dynamics prior to eruption (Table 3) These include examples of eruptions across a large range of differentiated magma volumes Comparison of diffusion timescales obtained for different large volume silicic eruptions By studying the geochemical signature of zircon and sanidines, the timescales of magma storage and differentiation of voluminous high-silica rhyolites at Yellowstone caldera (Wyoming) have been investigated (Stelten et al., 2015) the authors argue that eruptible rhyolites are generated by extracting melt and zircons from a long-lived mush of immobile crystal-rich magma Residence times of the large-volume rhyolites (∼40–70 km3) are ≤1 kyr (conservatively <6 kyr) which suggests that large volumes of rhyolite can be generated rapidly by extracting melt from a crystal mush the Yellowstone magmatic system evidences that magma reservoirs spend most of their time in a largely crystalline uneruptible state and that eruptible magma bodies are ephemeral features The coupled investigation of crystal and melt composition lead us to identify the disrupting event at depth responsible for the magma mobilization leading to two major explosive eruptions in Dominica interpreted using the revised CSA approach provides a detailed view of the pre-eruptive architecture and dynamics of the crystal mush prior to eruption This highlights the diverse complexity of the magmatic system with several magmatic environments and short remobilization timescales several Plinian eruptions in the central part of Dominica have been described and should be investigated to detail the plumbing system dynamics in time and space The raw data supporting the conclusions of this article will be made available by the authors wrote the submitted version with new figures DM helped during data acquisition and wrote the submitted version LO helped for data and figure management before submission This work is part of CS (financial support of the French MNRT doctoral Grant) We would like to thank the PPR fund of IPGP This study was partly founded by the program Tellus-Aleas of INSU (CNRS) and ANR V-CARE-18-CE03-0010 This work is part of the PhD thesis of Solaro-Müller (2017) DM would like to thank IPGP for the award of a visiting lectureship which enabled this work to take place Nicolas Rividi and Omar Boudouma are thanked for assistance during EPMA and SEM analyses The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/feart.2020.574032/full#supplementary-material and unrest during caldera collapse and lateral eruption at ocean island basaltic volcanoes (Piton de la Fournaise CrossRef Full Text | Google Scholar A cascade of magmatic events during the assembly and eruption of a super-sized magma body CrossRef Full Text | Google Scholar From mush to eruption in centuries: assembly of the super-sized Oruanui magma body CrossRef Full Text | Google Scholar From plutons to magma chambers: thermal constraints on the accumulation of eruptible silicic magma in the upper crust CrossRef Full Text | Google Scholar Rejuvenation of the fish canyon magma body: a window into the evolution of large-volume silicic magma systems CrossRef Full Text | Google Scholar Silicic magma reservoirs in the Earth’s crust CrossRef Full Text | Google Scholar Deep pre-eruptive storage of silicic magmas feeding plinian and dome-forming eruptions of central and northern Dominica (Lesser Antilles) inferred from volatile contents of melt inclusions CrossRef Full Text | Google Scholar and recharge of magma driving recent eruptions at a hyperactive caldera volcano CrossRef Full Text | Google Scholar Crustal magmatic systems from the perspective of heat transfer CrossRef Full Text | Google Scholar Martinique: évolution volcanologique Google Scholar Revised chronostratigraphy of recurrent ignimbritic eruptions in Dominica (Lesser Antilles Arc): implications on the behavior of the magma plumbing system CrossRef Full Text | Google Scholar What factors control superficial lava dome explosivity CrossRef Full Text | Google Scholar Subduction of Atlantic aseismic ridges and late cenozoic evolution of the lesser Antilles island arc CrossRef Full Text | Google Scholar The Roseau ash: Deep-sea tephra deposits from a major eruption on Dominica Vertically extensive and unstable magmatic systems: a unified view of igneous processes CrossRef Full Text | Google Scholar Diffusion in solid silicates: a tool to track timescales of processes comes of age doi:10.1146/annurev.earth.36.031207.124125 CrossRef Full Text | Google Scholar Timescales of mixing and mobilisation in the Bishop Tuff magma body: perspectives from diffusion chronometry CrossRef Full Text | Google Scholar Lithium concentration gradients in feldspar and quartz record the final minutes of magma ascent in an explosive supereruption CrossRef Full Text | Google Scholar Decadal time gaps between mafic intrusion and silicic eruption obtained from chemical zoning patterns in olivine CrossRef Full Text | Google Scholar Diffusion coupling between major and trace elements and a model for the calculation of magma chamber residence times using plagioclase CrossRef Full Text | Google Scholar “Time constraints from chemical equilibration in magmatic crystals,” in Timescales of magmatic processes: from core to atmosphere Google Scholar Diffusion chronometry and the timescales of magmatic processes CrossRef Full Text | Google Scholar Mineral disequilibrium in lavas explained by convective self-mixing in open magma chambers CrossRef Full Text | Google Scholar Diffusion timescales of magmatic processes in the Moinui lava eruption at Mauna Loa as inferred from bimodal olivine populations CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar Decadal to monthly timescales of magma transfer and reservoir growth at a caldera volcano CrossRef Full Text | Google Scholar Architecture and dynamics of magma reservoirs CrossRef Full Text | Google Scholar Multiple timescale constraints for high-flux magma chamber assembly prior to the Late Bronze Age eruption of Santorini (Greece) CrossRef Full Text | Google Scholar Fe 2+–Mg interdiffusion in orthopyroxene CrossRef Full Text | Google Scholar Structure and dynamics of the Laacher See magma chamber (Eifel Germany) from major and trace element zoning in sanidine: a cathodoluminescence and electron microprobe study CrossRef Full Text | Google Scholar Re‐evaluation of the Roseau Tuff eruptive sequence and other ignimbrites in Dominica CrossRef Full Text | Google Scholar Crystal-poor versus crystal-rich ignimbrites: a competition between stirring and reactivation CrossRef Full Text | Google Scholar Homogenization processes in silicic magma chambers by stirring and mushification (latent heat buffering) CrossRef Full Text | Google Scholar Two competing effects of volatiles on heat transfer in crystal-rich magmas: thermal insulation vs defrosting CrossRef Full Text | Google Scholar Dynamic plumbing system beneath volcanoes revealed by kinetic modeling and the connection to monitoring data: an example from Mt CrossRef Full Text | Google Scholar Constraints on the nature and evolution of the magma plumbing system of Mt Etna Volcano (1991–2008) from a combined thermodynamic and kinetic modelling of the compositional record of minerals CrossRef Full Text | Google Scholar Prolonged reactions between harzburgite xenoliths and silica-undersaturated melt: implications for dissolution and Fe-Mg interdiffusion rates of orthopyroxene CrossRef Full Text | Google Scholar Geochemistry and petrogenesis of late Pleistocene to recent volcanism in southern Dominica CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar Effect of fO2 and H2O on andesite phase relations between 2 and 4 kbars CrossRef Full Text | Google Scholar Timescales of magma recharge and reactivation of large silicic systems from Ti diffusion in quartz CrossRef Full Text | Google Scholar Time scales of crystal residence and magma chamber volume from modelling of diffusion profiles in phenocrysts: Vesuvius 1944 CrossRef Full Text | Google Scholar Google Scholar Thermometers and barometers for volcanic systems CrossRef Full Text | Google Scholar Variable regimes in magma systems documented in plagioclase zoning patterns: El Misti stratovolcano and Andahua monogenetic cones CrossRef Full Text | Google Scholar Crystal and melt inclusion timescales reveal the evolution of magma migration before eruption CrossRef Full Text | Google Scholar The magmatic evolution of the Whakamaru supereruption constrained by a microanalytical study of plagioclase and quartz CrossRef Full Text | Google Scholar Partly-welded pyroclast flow deposits in Dominica Plagioclase zoning as an indicator of magma processes at Bezymianny Volcano CrossRef Full Text | Google Scholar The volcanic geology of the mid-arc Island of Dominica CrossRef Full Text | Google Scholar Petrological and experimental constraints on magma storage for large pumiceous eruptions in Dominica island (Lesser Antilles) CrossRef Full Text | Google Scholar Solaro-Müller Storage conditions and dynamics of magma reservoirs feeding the major pumiceous eruptions of Dominica (Lesser Antilles arc) Paris (France): University Paris Diderot (Sorbonne Paris Cité) Google Scholar Dynamic magma systems: implications for forecasting volcanic activity CrossRef Full Text | Google Scholar Mechanisms and Timescales of Generating Eruptible Rhyolitic Magmas at Yellowstone Caldera from Zircon and Sanidine Geochronology and Geochemistry Comparison of volcanic production rates and subduction rates in the lesser Antilles and Central America doi:10.1130/0091-7613(1984)12<555:COVPRA>2.0.CO;2 CrossRef Full Text | Google Scholar An overview of the eruption of Soufrière Hills volcano CrossRef Full Text | Google Scholar Magma emplacement and remobilization timescales beneath Montserrat: insights from Sr and Ba zonation in plagioclase phenocrysts CrossRef Full Text | Google Scholar Martel C and Ostorero L (2020) A System Dynamics Approach to Understanding the deep Magma Plumbing System Beneath Dominica (Lesser Antilles) Received: 18 June 2020; Accepted: 14 October 2020;Published: 19 November 2020 Copyright © 2020 Solaro, Balcone-Boissard, Morgan, Boudon, Martel and Ostorero. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use *Correspondence: Hélène Balcone-Boissard, aGVsZW5lLmJhbGNvbmVfYm9pc3NhcmRAc29yYm9ubmUtdW5pdmVyc2l0ZS5mcg== Get important news about your town as it happens Get the top stories from across our network Are you sure you want to unsubscribe from daily updates The attorney representing the family of a Jefferson mom allegedly fatally shot by her Newark police lieutenant husband will soon be suing the officer and his department Christie Solaro Formisano allegedly was fatally shot by her estranged husband John Formisano A tort claim notice was filed by attorney Marco Laracca against John Formisano, who is accused of fatally shooting his wife Christie Solaro Formisano and wounding her boyfriend last July -- about a month after filing for divorce, NJ.com reports. The wrongful death suit will also argue that the Newark Police Department ignored warning signs from Formisano who Solaro's mom maintained should not have had a gun Formisano told police he went over to his estranged wife's home around 11 p.m July 14 to drop off a pair of glasses for one of their children and "blacked out" after suspecting Solaro was in the bedroom with her boyfriend Solaro fled to the neighbor's house for help and later died while her boyfriend A GoFundMe page for the Formisano children had raised more than $35,000 as of Saturday morning Click here for more from NJ.com. 2019 at 12:42 pm ET.css-79elbk{position:relative;}The community has come together to support the children of Christie Solaro NJ — Support has been pouring in from around the state for young Jefferson siblings' whose police officer father is accused of shooting their mother dead over the weekend Rachel and Ryan Formisano were home when their father John Formisano is accused of shooting their mother to death and seriously injuring her boyfriend but following the family-shattering tragedy "have a rough road ahead," a family friend has said Miko Velez, a retired police officer who worked with Formisano in Newark, established a GoFundMe account for the children that will only be accessible by their maternal uncle over $22,000 has been raised in three days to benefit the children "We hope to have Ellie back with the kids within the next week or so She is a such a sweet dog and full of love The kids will definitely benefit from having her around," Velez wrote "Had great conversations and we are working on getting a unified front to work together for the benefit of the children." Velez said the fundraiser was born out of a duty to take care of Ryan and Rachel."John is the brother I never had Johnny and I made a promise to each other more than 20 years ago that should anything happen to us John Formisano was taken into custody early Monday morning in a parking lot in Livingston several hours after he is accused of shooting Christie Solaro dead in the home the couple used to share When he began to suspect that Solaro had a man in the bedroom he began to "black out," Formisano told police Formisano is accused of shooting Solaro and T.S and Formisano shot her dead on a neighbor's front porch several houses over Formisano is currently in a psychiatric hospital in Boonton. Read More: 'Black Out:' Chilling Details In NJ Cop's Alleged Murder Of Wife GoFundMe is a Patch promotional partner Get more local news delivered straight to your inbox. Sign up for free Patch newsletters and alerts. By subscribing, you agree to our Terms of Use and Privacy Policy Ancient Rome once had its own Las Vegas and it can now be found submerged 13-feet under the sea Situated near the northwest shore around the Gulf of Naples the ancient city of Baiae was a resort town where Roman nobility would come to let loose The area was particularly attractive for its hot springs that sprung up from a neighboring supervolcano known as Campi Flegrei Caligula and Julius Caesar all had lavish villas in the region some of which are partially preserved at the Museum of Baiae Update your browser to view this website correctly. Update my browser now Solaro FR1 DSP centralises IP audio processing experts in digital signal processing technology for AV and installed sound IP-based DSP architecture at the new Estadio Unico Madre de Cuidades sports venue in Argentina Designed and integrated by Equaphon Sistemas de Sonido the system uses a Xilica Solaro FR1 DSP to streamline the costs and infrastructure typically required to process and distribute live event audio across a large outdoor stadium The Xilica architecture includes XTouch control solutions to manage stadium voice emergency and paging functions from three locations located in the city of Santiago del Estero officially opened this May and will welcome more fans into the stadium for future events including the Copa America men’s football championship in June 2021 The Solaro FR1 routes stadium public address (live voice paging and emergency notifications over a Dante network to 12 indoor and outdoor zones changing rooms and stadium entrances – processing high-quality Dante audio for 96 loudspeakers in the grandstand alone “Xilica audio and control integrates seamlessly with the stadium’s IT infrastructure allowing us to centralise core processing and other DSP functionality while taking advantage of the stadium’s fiber-optic ring and Dante network for distribution,” said Ruben Branca “Xilica’s clean interoperability with third-party AV and IT components also simplified system programming and routing paths during the design and integration phases which allowed us to both simplify and optimise deployment system operation and serviceability for the end user.” scalable Solaro FR1 effectively centralises DSP functions while de-centralising the 21 Powersoft amplifiers that serve all 12 zones This allowed the integration team to position amplifier racks at strategic points in the stadium while minimising cabling and associated costs Xilica Solaro XIO 8 modular expansion frames add value to stadium personnel through quick connection of external audio sources to the Dante network Xilica XTouch 80 touch screens enables simple and intuitive management of voice and audio within the Stadium Voice Booth and two monitoring posts tasked with security and emergency notifications The XT80 enables security personnel to override general PA audio to deliver emergency messages and safety instructions while announcers in the Stadium Booth voice can easily toggle between a handheld microphone All XTouch systems interoperate with amplifiers to manage volume control and other audio settings Rob Lane Rob has been writing about AV (pro and consumer) for more years than he cares to remember editing a number of well known CE mags through the ’90s and ’00s launching his own residential AV trade title in time for the very first ISE in 2004 while continuing to write for leading AV B2B publications in the UK and US Tags ⋅ ⋅ © 2025 Future Publishing Limited Quay House, The Ambury, Bath BA1 1UA. All rights reserved. England and Wales company registration number 2008885. The scene: Ristorante Monte Solaro, at the highest point on the Italian island of Capri, provides this scenic overlook. "Surrounding the restaurant are walking paths and overlooks of the vistas that unfold in every direction. The one that caught my eye was flanked by a Roman statue from the era of the emperor Tiberius. He loved the vistas so much that he used the island as his favorite retreat," Carpenter wrote in an e-mail. equipment: "My camera is a Canon G15 with a polarizer filter," Carpenter wrote. "I chose this camera for our travels because of its pocket size, zoom lens and very nice optical quality. It offers far superior enlargements and a crisper image compared to a camera phone and is much easier to carry around than a larger camera." Share your photos: To submit your travel photo for consideration to Viewfinders, share it on Instagram tagged with #STtravel, or e-mail a jpeg to viewfinders@startribune.com. No Section Peek inside homes for sale in the Twin Cities area After falling behind 17-0 at halftime and being dominated most of the game the Bulldogs may have locked up a spot in the College Football Playoff just before a funeral ceremony for the victims of the recent earthquake (Credit: Andreas Solaro/AFP/Getty Images)After an image of the crucifixion appeared at the scene of the devastating earthquake in Italy Kelly Grovier looks at the worlds of the living and the dead Against a backdrop of ruin and crumpled buildings a firefighter mounts a ladder – his ascent shadowed by the raised arms and levitating body of the crucified Christ that he affixes into place decoupled from the beams of the cross to which it was once attached appear to be propelling the emaciated frame upwards – its varnished physique soaring as if by its own gravity-defying powers Look closer and the image turns on itself as the rope that hoists the statue into position suddenly appears less supportive than lethal Taken amid funeral preparations in Amatrice in Italy for victims of the devastating earthquake that killed nearly 300 people the photo is a tight knot of consolation and despair and captures poignantly the anguished limbo in which survivors of disasters find themselves cruelly suspended Dominating the centre of the image is the open armature of the ladder: a prop we’re accustomed to seeing in depictions of the crucifixion But in most Old Masters’ portrayals of the subject – from Rogier Van Der Weyden to Peter Paul Rubens Fra Angelico to Rembrandt – traffic along the ladder moves in the opposite direction rather than being brought back down from a plane of torture Christ’s petrified body dangles precariously between suffering and salvation The upward movement of Christ’s body along the tangent that is implied by the ladder connects the world of physicality with one of the spirit it is not entirely without example and calls to mind a curious etching by the 16th-Century German polymath Augustin Hirschvogel entitled Christ Carries the Bodily Remains of the Dead up a Ladder” an unusually burly Christ holds in place with one hand a ladder that leans wonkily against a big-boned cross while he flings over his shoulder with the other a limp load of dead bodies that he has collected for the climb The image appears to hypothesise an endless conveyance of souls into the mystery of crucifixion and a ceaseless scavenging of the departed Placed alongside this week’s photo of a community still dividing from its ruins what belongs to the living and what belongs to the dead Hirschvogel’s strange etching reminds us of how short the distance is between those worlds If you would like to comment on this story or anything else you have seen on BBC Culture, head over to our Facebook page or message us on Twitter And if you liked this story, sign up for the weekly bbc.com features newsletter, called “If You Only Read 6 Things This Week”. 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A former Newark police lieutenant accused of killing his estranged wife was sued in federal court on Tuesday by the woman's boyfriend who also named the Newark Police Department and Timothy Simonson allegedly were shot multiple times on the evening of July 14, 2019 The lawsuit alleges that the city Police Department failed to strip Formisano of his gun and badge after he showed suicidal behavior and indicated in front of other officers that he was thinking of hurting himself the suit alleges that the Newark Police Department knew he had made these statements and knew of Formisano's "deteriorating mental state," which worried other officers but failed to provide him mental health treatment Simonson's lawyers filed a public records request for documents regarding complaints against Formisano and investigations of the officer but were denied Available public records showed Formisano was accused of serious misconduct only four years after becoming a police officer and was suspended for 35 days He was also reported twice for his use of force between 2012 and 2016 "That Formisano was actually disciplined is particularly stark and raises questions about his fitness for duty in light of the [fact] Newark Police Department was notorious for its consistent and systemic failure to properly supervise officers," the suit reads The lawsuit accuses the Police Department of failing to "properly train counsel or otherwise properly equip and control officers," including those who are known to use excessive or deadly force and are a potential danger to themselves and the community.  Newark Police Director Anthony Ambrose said Formisano is currently suspended without pay 911 recordings: Panic by Jefferson Township neighbors after Newark cop's estranged wife is shot EARLIER: Newark cop charged with fatally shooting wife will make first court appearance GOFUNDME: Donations sought for Jefferson children of Newark cop charged with killing estranged wife Solaro and Simonson went to bed at Solaro's Jefferson home at 9:30 p.m according to the lawsuit. Court documents show that Formisano had filed for divorce against Solaro in state Superior Court in Morris County on June 7 Solaro allegedly discovered Formisano holding his police-issued flashlight; he was still wearing his police uniform and carrying his service weapon he shot her multiple times in front of the house before kicking in the front door and shooting Simonson with hollow-tip bullets leaving Simonson to crawl to the living room with a shattered femur and call 911 Formisano told officers he “blacked out” when he saw that his wife was with a man in the bedroom and starting shooting The estranged couple's children were home at the time of the shooting Simonson was on the phone with 911 for over an hour while he bled A SWAT team was assembled before he was taken to Morristown Medical Center for emergency surgery Simonson was not the only person to call 911 one saying that Solaro was dying in front of her house She was found dead on the front steps of the neighbor's house with gunshot wounds in her abdomen Formisano was arrested the next morning at 1:30 a.m. in Livingston and charged with first-degree murder. He spent months in the psychiatric unit at St Clare’s Behavioral Health in Boonton Township and the Ann Klein Forensic Center in Trenton who pleaded not guilty in February, is expected to appear in court on Jan Kaitlyn Kanzler covers Essex County for NorthJersey.com For unlimited access to the most important news from your local community, please subscribe or activate your digital account today Email: kanzler@northjersey.com Twitter: @KaitlynKanzler8