2025Men's Golfvs NCAA RegionalsLoad MoreRecent ResultsCompleted Event: Softball at No Dante Teramo Joins Utah Men's Tennis Roster5/30/2024 2:25 PM | Men's Tennis (News 4 & Fox 11) — "I remember smoke and I remember just how fast everything happened." Flames engulfed a two story home on Teramo Court in Damonte Ranch in the early morning hours while the Barbee family slept The parents awoke to their worst nightmare "What really sticks in my mind is the moment during the fire when I couldn't get to the boys," said David Barbee "And feeling overcome by smoke and and feeling utterly defeated." The fire claimed the lives of the couple's two teenage boys Davis was a senior at Damonte Ranch High School His brother Travis was a student at Depaoli Middle School Investigators never determined what caused the fire only that it started in the garage and spread quickly But we have learned by sorting through copies of the dispatch records that a Truckee Meadows fire station that's only a few miles from the scene was not part of the initial response That's because Reno Fire did not ask for their help early on Truckee Meadows Fire Station 33 is located on Foothill Road It would have been an eight minute drive to the fire according to county fire officials Station 33 was called 39 minutes after the fact By that time they were headed to another call and could not respond to the house fire Reno Fire Chief Dave Cochran tells News 4 the city had plenty of its own resources available that night and didn't need the county's help early on But this incident is a clear reminder that with city and county fire crews operating independently as they do now the closest units don't always respond first That's because without automatic aid dispatch is based on city and county boundaries and not who is closest to the scene David Barbee says it troubles him to learn that a nearby fire station wasn't called immediately "My personal experience with the fire is that every second counted and every moment was critical," he said "I think in a situation where seconds are critical you throw everything at it." It's an issue both sides promised to fix two years ago when we found there was a delayed response to a crash at the Great Clips Salon in south Reno because of the lack of automatic aid "We recognize that that's a problem the county recognizes that's a problem and we're going to address that," John McNamara with the Reno Fire Department told News 4 in 2022 There's no way of knowing whether one more crew would have made a difference the night of the Teramo fire wondering if it could have doesn't make things any easier "It certainly leaves a question in my mind," David said The Barbee's are focused now on moving forward They are doing their best to live productive lives Davis and Travis are in their thoughts every step of the way "I know they're in heaven right now just looking at us," she said "If we're sad they'll be sad If I'm happy they're happy too." The Barbees say they are grateful for the firefighters who responded and did their best to try to save their son's lives But automatic aid continues to be a sensitive issue Neither the Reno nor the Truckee Meadows Fire Chief was willing to speak on camera for his story We've been told talks are continuing behind the scenes to try and hammer out an agreement that would provide for automatic aid between the two agencies We'll let you know when there's anything new to report stretches an area of great scenic interest right at the foot of the Gran Sasso: in the foreground are rounded hills dotted with sheep pastures and cultivated fields; on the horizon the sleeping Giant During the day you can enjoy extraordinary panoramic views; on the contrary at night it is difficult to locate the right direction since the absence of light and distinct landmark sites This is why I suggest setting Contrada Camerale on Google Maps The exterior is brightly lit and atmospheric: the structure features a large canopy designed to shelter tables and chairs from the heat and direct rays during the summer while from the large windows and vestibule Crossing the threshold I had the perception that despite the small space there were elements that amplified its depth without weighing it down velvet sofa mixes with the surrounding atmosphere The brick walls are emphasized by wall sconces and hanging lanterns; on the other hand the rough wood counter with pronounced grain blends with the essential details of the mise en place: the heterogeneous tables As does the double-drawer cutlery box on each station “I never liked to see waiters replace the dishes you have to be free to choose what you eat with,” gridded ceiling lends an additional industrial touch to the ambiance and his sous chef and curator of the wine list and pairings both from Abruzzo and former students of the Di Poppa-Rozzi Hotelier Institute while maintaining strong ties to their home region have accumulated varied experiences around the world when L'Aquila was partially destroyed by the earthquake I had been offered an opportunity at Hotel Saturnia Heinz Beck 's one-Michelin-starred restaurant at The Lanesborough It was a year and a half full of discoveries; I learned a lot there As we moved up the ranks the duties changed: I was even called to take on the role of sous chef at Castello di Fighine in Tuscany I've come a long way: I've worked at Pipero's Rex at Crescenzo Scotti's Cappero (Michelin star in the Aeolian Islands) to get a sense of the situation: there were so many entrepreneurs exclusively adapting to customer demands and following the trends of the moment in order to make money he had come to leave his resume at Carducci Bistrot I recognized him right away and contacted him; without knowing it he took my place when I left La Caravella and Silvano Urban and it was precisely I who hosted him in the English capital when he came for a consultation and I only had time to hand him the keys to the apartment without being able to chat "I was 14 years old when I began to approach the industry the latter believed I was more suited to cooking although I had always been passionate about mixology In 2020 I worked with Marcello Rossi on the Adriatic coast the adventure did not last long because of the pandemic the intrepid people transformed what was once a pub into a gourmet giving the location back an identity and downsizing it from 80 covers to 25 So the opening takes place in February 2023 suet and almonds; eggplant carpaccio macerated in beet juice peanut and edible flower mayonnaise; olive mousse tasseled with parsley oil; vegetable-filled cannoli; steamed pizzette carrot cream and lardo di colonnata; a reinterpretation of a local classic and enriched with pecorino mousse; walnuts and gorgonzola with which I would have ended the evening directly - in beauty Accompanied by a glass of Trento DOC Brut Millesimato Endrizzi crusco bell pepper breadsticks and two different types of bread A butter candle literally blew me away; it was a pleasant surprise of which I had not been warned We continue with a coffee-marinated duck ham with foie gras The seared scallop with Jerusalem artichoke sauce and chips is the dish that perhaps best represents the philosophy of the two young men at the stove we prefer to follow the school of the master Heinz: few ingredients but clean The combination is designed to enhance without overpowering played on precise balances and soft contrasts Hors d'oeuvres end with sweetbreads glazed with brown base and scented with sage It goes very well with a Marramiero Altare First propose their workhorse: fagottelli stuffed with cacio e pepe liquid white truffle shavings and white stock is tender and pink it means the cooking was done to perfection Freshness and acidity clash with sweetness certainly that tickle typical of red fruits prevails and a fiordilatte ice cream with cocoa crumble But what really struck me was the artisanal panettone with zabaglione and coffee air prepared live before our eyes condensing and magically landing on the plate like a raindrop intoxicated by the fragrance that filled the living room at home I always ask in the doorway already wearing my coat “We would like to cooperate more with prominent local personalities in the field of food and wine” "I am currently overseeing the renovation of a farmhouse in Faiano we continue to give moments of happiness; it is what allowed us to enter among the new entries in the Michelin Guide" Website Do you want to discover the latest news and recipes of the most renowned chefs and restaurants in the world La nostra società utilizza inoltre cookie funzionali per registrare informazioni sulle scelte dell’utente e per consentire una personalizzazione del Sito; ad esempio Questi cookie possono essere installati dalla nostra società o da Terze parti In caso di disabilitazione di questi cookie la qualità e l’esperienza di navigazione potrebbe non essere soddisfacente Questi cookie sono installati da social media per consentire la condivisione dei contenuti del presente Sito Essi sono in grado di monitorare la navigazione compiuta anche in altri siti e creano un profilo dell’utente sulla base dei suoi interessi Ciò potrebbe avere un impatto sul contenuto e messaggi visualizzati sugli altri siti visitati non sarà possibile utilizzare o visualizzare questi strumenti di condivisione per l’installazione e l’uso di tali cookie occorre il consenso dell’utente Per maggiori informazioni consulta la pagna cookies policy ROME (Lega A) - Lottomatica Roma followed up their home win over Maccabi Tel Aviv in the Euroleague with an 80-62 rout of Armani Jeans Milano in the Lega A.\r\n\r\nSasa Filipovski's Romans, whipped the previous weekend at Benetton Treviso, are in eighth place.\r\n\r\nThey only led 36-35 at half-time but outscored Milano 20-8 in the third quarter to take ... whipped the previous weekend at Benetton Treviso They only led 36-35 at half-time but outscored Milano 20-8 in the third quarter to take .. Here’s the Pop Culture Jeopardy Final Jeopardy (in the category Alphanumeric Company Names) for Wednesday, December 18, 2024 (Season 1, Game 9): (correct response beneath the contestants) (The following write-up is original content and is copyright 2024 The Jeopardy! Fan. It may not be copied without linked attribution back to this page.) Founder Daniel Katz was driving on the A24 (Autostrada 24) in Italy when the name of the route gave him the inspiration for his production company name. Founding the company with David Fenkel and John Hodges, the company has produced films such as Everything Everywhere All at Once, Lady Bird, and Moonlight. Here’s the recap for Season 1, Episode 9: (Categories: Maid For TV; The Tony Awards; Walter Egos; Jock Of All Trades; ____ & ____; Metal Fest) Glazed and Confused, while not quite getting of to as hot of a start as a team did in Episode 8, did pick up 9 correct responses, and the Daily Double, to lead after 15. At the interviews, the scores were Glazed and Confused 8,600 Tampa Tamales 2,000 Brennith 400. Glazed and Confused picked up another seven correct to continue leading after 30 clues. (Categories: Frontmen; Video Game To Film; Calendar Girls; TV Show Change A Letter; Great Brits; Celebrity Makeup) While Glazed picked up 12 correct, they went conservative on DD3, betting only 2,000; this left an opening for Tampa, who swept the round’s Triple Play to pull within striking distance going into clue 61. Brennith ran out of time, preventing this from being a triple get. Glazed and Confused advances by 1 point after a skillful cover bet. † – selection in same category as Daily Double (Scores: Glazed and Confused 26,600 Tampa Tamales 17,200 Brennith 8,000) Tampa Tamales: You have to be correct to win—go all in. (Actual bet: 17,200) Glazed and Confused: Standard cover bet over Tampa Tamales is 7,801. (Actual bet: 7,801) Brennith: You can’t win unless “Glazed…” overbets, but you might as well go all in just in case they do. (Actual bet: 7,999) I also thought the winning team’s screen looked too much like “A2U”! [But that’s my nature, as I am always very careful to fill in forms, write checks, etc. VERY legibly.] For the record, as soon as the FJ was displayed/read I’d thought that the correct response was bound to be “A24”. San Benedetto, 13 April 2025 – Big party at Bonolis where the Sambenedettese away defeats Teramo 2-1 and returns to the professionals after a four-year absence.  The University of Teramo in Italy has signed an agreement that will pave the way to forge a closer collaboration on research training and student mobility with African universities Thanks to a partnership with the committee Comitato Centenario Canonizzazione San Gabriele the university will admit African students into its degree courses with a fee waiver while the committee will look after their accommodation “The agreement signed today represents a first concrete step on the ‘Teramo Declaration’” The agreement also includes internships and training for African students and students from the University of Teramo In the words of the university’s rector Dino Mastracola this is the first concrete step since the signing of the ‘Teramo Declaration’ in June during a conference attended by the rectors of 29 African universities and will pave the way for further collaboration “The agreement signed today represents a first concrete step on the ‘Teramo Declaration’,” he said in a statement “It’s important to not only offer African students the possibility to attend our university’s degree courses but also to undertake a process leading to the mutual recognition of joint degrees and offer our students the opportunity to carry out internships in African universities.” The president of the Comitato Centenario Canonizzazione San Gabriele underlined that the agreement also marks the creation of a student home for “deserving” foreign students in the city which has the potential to attract more students to Teramo The Teramo Declaration was signed during the International Forum of the Gran Sasso in June in a  conference with African university rectors hosted by the University of Teramo The conference represented “an extraordinary event” for the university and he expressed the hope it would lead to the possibility of building shared educational pathways “to train professionals able to realise projects based on a new vision of reciprocal development” About The PIE News Regions Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here Nestled between the slopes of the sleeping giant and the endless whisper of the Adriatic Sea which carry water between the hills and the center like vital arteries there is a nostalgic atmosphere: the stones of the Romanesque cathedral dedicated to Santa Maria Assunta stand adjacent to Piazza Martiri della Libertà and Piazza Ercole Vincenzo Orsini the 50-meter tower is not only a religious symbol but a soul with an elegant profile that watches over its inhabitants gone are the shadows reflected by the last rays of the sun sinuous glimpses and iridescent lights cross Interamnia you will seem to hear the magical notes of Ivan Graziani walled in a house along the Corso di Porta Romana at the height of the Church of the Holy Spirit a temple of three young people guided by the strength of a common desire Driven by the hope of renewing the reality of a city that has seen them grow up that that dream is becoming tangible and concrete Jacopo Divisi (27) and Paride Furia (28) in the kitchen the latter with an established experience behind him a Michelin star on the outskirts of Bergamo; and Luca Mercadante (31) three grandchildren made in Abruzzo who have inherited their grandmothers' gastronomic baggage after experimenting here and there around the province because although they are not blood-related Lending a hand when needed - again to stay on topic - Vera and Ludovica Two ladies who deal with something else entirely in life but who manage with elegance and discretion to handle the service excellently aware that the common thought is that people do not go out to eat to enjoy the great classics because there are those who prepare them better at home And then the debut as a new entry among the pages of Gambero Rosso's Guide Ristoranti d'Italia 2025 and in Slow Food's Guide Osterie d'Italia 2025 “We did not expect all this,” declares Divisi excitedly although visually we tried to imprint an authentic trace for example the timballo we served with a mousse one step at a time they built an intimate space where they could accommodate thirty people and seasonal “We only source from small local distributors at this time we will be releasing the last semi-milk with the remaining milk After that we should find a worthy replacement so much so that in the appetizers we played with offal unfortunately today's thermal conditions do not help a three-meat patty on creamed pumpkin and spinach powder a vibrant amuse-bouche with a delicate vegetal note that anticipates the level of the following courses Low-temperature cooking preserves its tenderness and natural juices; thin slices like satin ribbons are laid on the bottom and sprinkled in abundance with the dressing Paired with a pure Cococciola sparkling wine an indigenous white berry variety of the region Podere Francesco plum jam and tomato powder The elements have been skillfully repurposed in textures the crispness of the crust clashing harmoniously with the stringy interior while the acidity pushes through without overlapping the rest Perfectly balanced is the organic CBT egg Mediterranean style a delicacy for those who love simple things evoking the fervor of the earth and its precious fruits My advice is to savor all the ingredients in a single spoonful A beautiful truth that reveals itself slowly illuminating the path of those who interpret it correctly As a first course we got pappardelle with beef paired with a glass of Chardonnay Alto Adige DOC Kellerei St.Pauls on the fruity finish; a combo that underlines Luca's care and enthusiasm although not all patrons appreciate the cut: it melts in a bite We end on a high (and sweet) note with a vanilla and chamomile panna cotta Of the activity we particularly appreciated the constant desire to improve and the smiles on the faces of a new generation that deserves to be supported now and in the future silent and respectful energy that defies the conservative mindset is a powerful and indispensable tool in the hands of those who have no intention of giving up; and with those same hands they sow day by day Website Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors A recent Reno Fire Department report is adding new details about a house fire that killed two teens late last year The fire broke out on Teramo Court west of Veterans Parkway just before 3 a.m An investigation is underway after the fire the house was engulfed in flames and eventually the roof collapsed crews had to stop searching for possible victims 19-year-old Davis Barbee had been rescued and was taken to a nearby hospital for treatment 13-year-old Travis Barbee in an upstairs bedroom Reno Fire says two firefighters were also injured - one suffered burns to his leg More than 40 personnel responded to the fire as well as Truckee Meadows Fire & Rescue Fire crews contained the fire to just the one house The fire remains under official investigation The report does not state a definitive cause either except that the fire started on the south side of the garage friends and neighbors impacted by this tragic incident,” said Reno Fire Chief Dave Cochran “The men and women of the Reno Fire Department acted swiftly and put forth an extraordinary effort to perform two rescues and extinguish this fire we join our community in mourning this terrible tragedy.” Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Get up-to-the-minute news sent straight to your device Wines from Abruzzo have long been recognised by their producer rather than the appellation but as the Consorzio di Tutela Vini Colline Teramane hits its 20th anniversary There are many great wines produced in Abruzzo a region right between the Adriatic Sea and the massive mountains of the Apennines grandiose mountains that well exceed 2,000 meters in height However too often the wines of this region have been known only thanks to name of the single most famous producers rather than to the territory where the wines are born To recognise a great wine produced in Abruzzo the name of the producer has always been first and that of the appellation There is one major denomination called Abruzzo DOC And until recently there was no evocative story capable of catching consumers The history of the Consorzio di Tutela Vini Colline Teramane was born with the idea to build an identity of an entire agricultural and productive community Colline Teramane was not even a historically existing name But a group of capable and far-sighted wine producers began to understand that a here Montepulciano had a character of its own A wine with very intriguing characteristics of depth aromatic complexity and an immediate and yet strong character The Montepulciano produced in the Teramo hills was the key to understanding a territorial diversity that needed to be told and promoted Because historically Montepulciano  produced in this area has always been a fine wine a wine that has always commanded higher average prices than the rest of Abruzzo And the producers of the area understood that this diversity had to be told and protected and therefore created an appellation that did not exist before In 2003 a group of founding wineries managed to get the DOCG for Montepulciano d’Abruzzo Colline Teramane – the first DOCG of the Abruzzo region- Today it can be produced in 33 municipalities entirely included in the province of Teramo A place formerly suited to viticulture and historically dedicated to the vinification of its grapes circumscribed between the Adriatic Sea and the mountain ranges of Gran Sasso and Monti della Laga a habitat and a microclimate that ensure Montepulciano optimal conditions for maturation and great quality and typicality in the glass and a production that has doubled in the last two years alone Montepulciano d’Abruzzo Colline Teramane has become an example of excellent quality and a strong identity A wine capable of expressing and perfectly be the voice of the territory in which it is produced  Territory that embraces the entire coastal and inland hills of the province of Teramo Characterised to the east by wide and sinuous hills that slide towards the Adriatic Sea and to the north-west by the imposing presence of the Gran Sasso and the Monti della Laga The sea and mountain breezes that caress and clean the vineyards together with the clay-silty nature of the soils made up of plio-plestocene deposits the excellent rainfall and the considerable temperature variations between day and night favoured by the nearby mountains guarantee Montepulciano unique and optimal that translate into great  terroir wines The Teramo hills are also characterised by a very particular hydrographic configuration with four valleys bathed by as many rivers Satinello and Vibrata which guarantee excellent humidity and biodiversity for the whole area Twenty years after the creation of the DOCG the Consorzio di Tutela Vini Colline Teramane DOCG has decided to sum up and investigate the close link that has been created in this area between man the environment and the Montepulciano grape which has given life to unique and well recognizable wine even if the production styles that are not yet totally homogeneous The producers of the Teramo Hills still present very different styles and ideas of refinement which means that there may be wines of different vintages on the market All this makes it harder to read this territory The production disciplinary is very stringent on yields with over 70% of the companies operating under a certified organic integrated pest management or biodynamic quality regime But in terms of refinements it leaves a lot of freedom to the producers The ‘annata’ (the lowest and youngest wines from any given vintage) comes out the cellar a year after the harvest while the Riserva must age for at least three years (including a minimum of one year in wooden barrels) Producers are very free to experiment with different possibilities of vinification and refinement that a versatile grape like Montepulciano offers them The result is on average very pleasing and of excellent average quality but the whole pictures is perhaps yet too uneven and not easy to read The style of the wine makers makers varies a lot There are those who seek spontaneity and integrity more declined towards fruit and drinkability or those who instead remain anchored to richer and more enveloping concentrations perhaps dedicated more to the international market But in this lack of homogeneity there is still a clear  organoleptic markers that Montepulciano from the Teramo hills manages to express punctually and clearly in the glass An acidity and a dynamic energy with great savoury and ageing potential traits the vintages tasted were many as well as the very  different styles Basically the 2021 and 2020 have given wines of great pleasure and drinkability that can only improve in the years to come with little rain and also characterised by summer hailstorms that didn’t help 2018 and 2016 were years of great climatic balance which gave excellent wines and 2017 was quite hot and dry but which gave perhaps the best wines dark and full even to the nose where it offers a nice fruity Very juicy palate with a full-bodied  and vibrant like plums and dark cherries On the nose it opens releasing hints of humus refreshing and very pleasant with a juniper blood orange and pleasant bitter finish with firm tannins On the palate everything plays out with refreshing tones crunchiness and a pleasant almost citrine acidity A perfect tannic touch and a lingering elegant finish The nose is fresh thanks to a decisive balsamic breath very clean and elegant with little extract and more elegance Even in the mouth there is always the finesse that marks and defines it with a beautiful salty length on the finish The tannins are firm but not impetuous and the sip is truly surprising thanks to the beautiful citrus on the finish woods and undergrowth then opens towards a more mature fruit character that continues its show even on the palate where the sip is full but flows agile and dynamic A full-bodied wine with roasted almonds and a great smoky touch on the very long finish An aromatic nose typical of the variety: blackberry and small berries notes of earth and humus and a beautiful ferrous minerality agility and a lot of elegance where the notes of ripe fruit comes back It is a wine that begins its full expressiveness now but it will last for many years Great structure and excellent drinkability at once salty and very well balanced structure with a delicate but very vital lean finish The nose is spicy and balsamic with medicinal herbs Very savory palate  with a long balsamic final wave that makes the sip satisfying and very voluptuous A wine that makes us understand how the Montepulciano of the Teramo hills has a serious aging potential It still keeps the currant and blueberry fruit intact and crunchy The palate shows mature expressive fullness complex and austere but very lively and vibrant with an acidity that dances around the mature and very pleasant tannins We are using cookies to give you the best experience on our website You can find out more about which cookies we are using or switch them off in settings This website uses cookies so that we can provide you with the best user experience possible Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings we will not be able to save your preferences This means that every time you visit this website you will need to enable or disable cookies again Volume 10 - 2020 | https://doi.org/10.3389/fonc.2020.00152 This article is part of the Research TopicGenomics of Lymphoproliferative DiseaseView all 12 articles Large granular lymphocyte leukemia (LGLL) is a chronic proliferation of clonal cytotoxic lymphocytes usually presenting with cytopenias and yet lacking a specific therapy including different subsets of patients distinguished by LGL immunophenotype (CD8+ Tαβ NK) and the clinical course of the disease (indolent/symptomatic/aggressive) Even if the etiology of LGLL remains elusive evidence is accumulating on the genetic landscape driving and/or sustaining chronic LGL proliferations The most common gain-of-function mutations identified in LGLL patients are on STAT3 and STAT5b genes which have been recently recognized as clonal markers and were included in the 2017 WHO classification of the disease A significant correlation between STAT3 mutations and symptomatic disease has been highlighted STAT5b mutations could have a different clinical impact based on the immunophenotype of the mutated clone they are regarded as the signature of an aggressive clinical course with a poor prognosis in CD8+ T-LGLL and aggressive NK cell leukemia while they are devoid of negative prognostic significance in CD4+ T-LGLL and Tγδ LGLL Knowing the specific distribution of STAT mutations helps identify the discrete mechanisms sustaining LGL proliferations in the corresponding disease subsets Some patients equipped with wild type STAT genes are characterized by less frequent mutations in different genes suggesting that other pathogenetic mechanisms are likely to be involved we discuss how the LGLL mutational pattern allows a more precise and detailed tumor stratification suggesting new parameters for better management of the disease and hopefully paving the way for a targeted clinical approach These findings suggest that in patients devoid of STAT3 mutations other mechanisms or lesions can be responsible of the activation of STAT3 pathway Figure 1. STAT3 and STAT5b mutations described in T-LGLL and CLPD-NK. The STAT3 and STAT5b mutations, reported up to now in literature (13–32) are indicated on their position in the exon upstream the corresponding protein domain The point mutations and the insertions/deletions are reported above and below the schematic representation of the gene TNFα-induced protein 3 (TNFAIP3) is another gene recurrently mutated in T-LGLL, that has been found altered in 4 cases within a cohort of 39 patients (24) This gene is a tumor suppressor that encodes A20 a negative regulator of nuclear factor kappa B (NF-kB) whose mutated form likely contributes to deregulate NF-kB activity the association between TNFAIP3 and STAT3 mutations (3 out of 4 cases simultaneously carry both mutations) suggests that TNFAIP3 lesion is not only an alternative genetic mechanism to STAT alterations but rather an additional event concurring to induce the LGLL phenotype These data emphasize the central role of JAK/STAT pathway in T-LGLL patients regardless of STAT mutational pattern this analysis demonstrates that several genetic lesions affect different functionally connected genes that can concur to drive a similar phenotype Differently from T-LGLL, CLPD-NK appears to be devoid of STAT5b genetic lesions (15, 38, 39), with the only exception of the aggressive case discussed by Rajala et al., who subsequently developed ANKL (28) In line with T-LGLL, TNFAIP3 mutation has been found in one out of 17 CLPD-NK patients (5.9%) (38) Several points should be made in terms of the STAT5b mutations. STAT5b N642H has been indeed identified as an oncogenic driver in innate-like lymphocytes (48), and a mouse model expressing human N642H mutated STAT5b has been described to develop severe CD8+ T cell neoplasia (49). Provided that IL-15 is an upstream factor of STAT5b and that IL-15 transgenic mice develops the aggressive variant of T or NK cell leukemia (50) the IL-15-STAT5 axis might be considered crucial for neoplastic transformation The requirement of additional cytokine signals on STAT5b genetic lesions suggests that the indolent course of CD4+ T-LGLL or Tγδ LGLL carrying these genetic lesions might be due to the lack of one or more concurring events together with STAT5b mutations These data emphasize the role of STAT3 activation in the pathogenesis of LGLL neutropenia with STAT3 mutations likely being involved in further boosting this mechanism potential parameter to select the initial best therapy for LGLL patients The correlation found between STAT mutations and LGL immunophenotype has been highlighted in fact STAT3 and STAT5b mutations are mutually exclusive and preferentially occur in phenotypically distinct leukemic LGLs Within Tαβ-LGL disorders, STAT3 mutations characterize the CD8+ T-LGLL and have never been observed in the CD4+ subset (14, 29). Instead, STAT5b mutations have been mainly found in CD4+ TLGLL and also in the rare aggressive form of CD8+ T-LGLL (28), whereas in indolent CD8+ T-LGLL these genetic lesions seem to be rare (14, 29) Also in CLPD-NK discrete subtypes can be identified by flow analysis. We observed that patients with CD56−/dim/CD16high/CD57− cytotoxic NK cells expansion include a subgroup characterized by a more symptomatic disease and the presence of STAT3 mutation (39) no STAT mutation-linked phenotypes have been reported Taken together, these data suggest that STAT3 mutation can occur in CD16+/CD56– LGLs, whereas STAT5b mutation may be detectable in CD56+ LGL (Figure 2) This link suggests that CD16+/CD56– LGLs and CD56+ LGLs preferentially use STAT3 or STAT5b signaling to develop LGL expansion and consequently they are differentially predisposed to be genetically hit The nature of this relationship remains an open issue that needs to be elucidated A larger analysis on CLPD-NK and Tγδ LGLL cases is mandatory to get insights also in these less frequent disorders STAT3 and STAT5b mutations are preferentially found in phenotypically distinct LGL disorders and can correlate with different clinical presentations The gain-of-function mutations in STAT3 and STAT5b genes up to now remain the most frequent abnormalities in LGLL even if additional genetic lesions in STAT-related or cancer genes have been described The complexity on the genetic background indicates that LGLL can be the result of different mechanisms emphasizing the heterogeneity of the disease even if a highly frequent recurrent genetic event has not been demonstrated Being the most common and specific for this disorder STAT3 mutation currently remains the genetic marker suggestive of LGLL whereas STAT5b gene is frequently described mutated also in many other hematologic diseases beyond LGLL Molecular analysis of STAT3 and STAT5b is unfortunately not so widely available nowadays but the evidence that STAT mutations have a clinical impact supports the inclusion of this test in the LGLL diagnostic work-up the evaluation of STAT mutations is suggested in combination with LGL immunophenotype data to perform an appropriate classification of indolent STAT3 mutation is indicative of symptomatic disease and reduced patient survival; its evaluation is preferentially suggested for patients affected by CD8 T-LGLL particularly when clonal expansion is sustained by CD16+/CD56– LGLs STAT5b mutation has a controversial significance depending on the immunophenotype of the mutated clone it is regarded as the signature of an aggressive clinical course with a poor prognosis in CD8+ TLGLL characterized by CD56+/CD16–/CD57– LGLs while it is devoid of negative prognostic significance in CD4+ T-LGLL and Tγδ LGLL the key factors addressing these two different clinical courses are currently unknown STAT3 and STAT5b mutations have been included in the 2017 WHO classification of LGLL with the indication that STAT5b mutation is associated with a more aggressive disease (12) Now this statement needs to be updated (i) highlighting the correlation between STAT3 mutation symptomatic disease and short patient survival and (ii) adding the issue of discovery of STAT5b genetic lesions also to indolent CD4+ T-LGLL and Tγδ LGLL in terms of aggressive LGLL harboring STAT5b mutation the current WHO classification recognizes only ANKL but does not yet recognize the T-related variants as a separate entity the introduction of STAT mutation screening as diagnostic tool together with a correct immunophenotypic analysis is encouraged for an accurate characterization of LGLL patients and GC discussed the topics of the manuscript CV and VG contributed to check the data contained in the manuscript and approved the final version of the manuscript This study was supported by Associazione Italiana per la Ricerca sul Cancro to GS (AIRC The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest Large granular lymphocyte disorders: new etiopathogenetic clues as a rationale for innovative therapeutic approaches LGL leukemia: from pathogenesis to treatment T cell large granular lymphocyte leukemia and chronic NK lymphocytosis Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells The lymphoproliferative disease of granular lymphocytes A heterogeneous disorder ranging from indolent to aggressive conditions doi: 10.1002/1097-0142(19871215)60:12<2971::AID-CNCR2820601220>3.0.CO;2-O Latest advances in the diagnosis and treatment of large granular lymphocytic leukemia Immunosuppressive therapy of LGL leukemia: prospective multicenter phase II study by the Eastern Cooperative Oncology Group (E5998) Network model of survival signaling in large granular lymphocyte leukemia Activating KIRs in chronic lymphoproliferative disorder of NK cells: protection from viruses and disease induction Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression The STATs of cancer–new molecular targets come of age The 2017 WHO update on mature T- and natural killer (NK) cell neoplasms Somatic STAT3 mutations in large granular lymphocytic leukemia STAT3 mutation impacts biological and clinical features of T-LGL leukemia Stat3 mutations impact on overall survival in large granular lymphocyte leukemia: a single-center experience of 205 patients STAT3 mutations are frequent in CD30+ T-cell lymphomas and T-cell large granular lymphocytic leukemia STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia STAT3 mutations are highly specific for large granular lymphocytic leukemia Clinical relevance of sensitive and quantitative STAT3 mutation analysis using next-generation sequencing in T-cell large granular lymphocytic leukemia Deep sequencing of the T-cell receptor repertoire in CD8+ T-large granular lymphocyte leukemia identifies signature landscapes STAT3 gene mutations and their association with pure red cell aplasia in large granular lymphocyte leukemia STAT3 mutations are frequent in Tcell large granular lymphocytic leukemia with pure red cell aplasia The analysis of clonal diversity and therapy responses using STAT3 mutations as a molecular marker in large granular lymphocytic leukemia Recurrent alterations of TNFAIP3 (A20) in T-cell large granular lymphocytic leukemia Clinical features and treatment outcomes in large granular lymphocytic leukemia (LGLL) STAT3 mutation and its clinical and histopathologic correlation in T-cell large granular lymphocytic leukemia Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia Tofacitinib as a novel salvage therapy for refractory T-cell large granular lymphocytic leukemia and mycobacterial disease in patients with activating mutations in STAT3 Systematic STAT3 sequencing in patients with unexplained cytopenias identifies unsuspected large granular lymphocytic leukemia Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation A guilt-by-association mutation network in LGL leukemia and TET2 mutations in T-LGL leukemia with molecularly distinct clonal hematopoiesis of indeterminate potential Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach Are T-LGL leukemia and NK-chronic lymphoproliferative disorder really two distinct diseases STAT3 mutations in natural killer cells are associated with cytopenia in patients with chronic lymphoproliferative disorder of natural killer cells Dominant cytotoxic NK cell subset within CLPD-NK patients identifies a more aggressive NK cell proliferation Chronic natural killer lymphoproliferative disorders: characteristics of an international cohort of 70 patients A first highdefinition landscape of somatic mutations in chronic lymphoproliferative disorder of NK cells 24th Congress of the European Hematology Association Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target Subclonal STAT3 mutations solidify clonal dominance STAT3 mutations are not sufficient to induce large granular lymphocytic leukaemia in mice Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation STAT3 mutations identified in human hematologic neoplasms induce myeloid malignancies in a mouse bone marrow transplantation model Intrinsic and extrinsic mechanisms contribute to maintain the JAK/STAT pathway aberrantly activated in T-type large granular lymphocyte leukemia STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia STAT5BN642H is a driver mutation for T cell neoplasia Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells Identification of a miR-146b-FasL axis in the development of neutropenia in T large granular lymphocyte leukemia Somatic mutations in clonally expanded cytotoxic T lymphocytes in patients with newly diagnosed rheumatoid arthritis Clonotype and mutational pattern in TCRγδ large granular lymphocyte leukemia 22nd Congress of the European Hematology Association Google Scholar STAT3 activation and oncogenesis in lymphoma Direct targeting options for STAT3 and STAT5 in cancer Novel activators and small-molecule inhibitors of STAT3 in cancer Results from a first-in-human study of BNZ-1 a selective multicytokine inhibitor targeting members of the common gamma (γc) family of cytokines chronic lymphoproliferative disease of NK cells (CLPD-NK) Semenzato G and Zambello R (2020) Insights Into Genetic Landscape of Large Granular Lymphocyte Leukemia Received: 21 November 2019; Accepted: 28 January 2020; Published: 18 February 2020 Copyright © 2020 Teramo, Barilà, Calabretto, Vicenzetto, Gasparini, Semenzato and Zambello. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Gianpietro Semenzato, Zy5zZW1lbnphdG9AdW5pcGQuaXQ= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish The day after tomorrow you will face the Teramo that is, the second force of the championship: "Each game is truly a story in itself: we have played great games both against the big teams and against the teams fighting for survival. I wouldn't give too much weight to the standings: each time it is a different game to face both on a technical-tactical level and on a mental level in the knowledge that a lot, as always, depends on us". René Jacobs and the B’Rock Orchestra fizz in youthful Schubert the complete works of a Renaissance eccentric and they maximise the potential of these works with raw This Ghent-based baroque orchestra digs into the urgency of No 4 “The Tragic” pensive introduction and the use of four horns instead of the customary two It’s also the first he wrote in a minor key carry its lightness with charm and a glint of steel: exhilarating performances all round giving a riveting insight into this eccentric contemporary of Donatello and Brunelleschi to Hieronymus Bosch in his appetite for the erotic often adapting his own music to liturgical purpose Watch a trailer for Enigma Fortuna. In the Royal Albert Hall, or on Radio 3/BBC Sounds, a chance to hear a large-scale orchestral work after a year or more’s absence: Mahler’s Symphony No 5 played by the specially assembled Proms Festival Orchestra – made up of leading freelance musicians – conducted by Mark Wigglesworth This is the archive of The Observer up until 21/04/2025 The Observer is now owned and operated by Tortoise Media I've had ercol's Teramo bed frame on my wishlist forever – this Habitat alternative offers a similar look for over £800 less I haven't yet seen anything that's tempted me to part with my cash combining a minimalist contemporary design with the timeless appeal of wood the Chiltern bed frame has a carved top and bottom bar and rounded legs the timeless Teramo Bed Frame features a headboard made from turned wooden spindles and elegantly tapered legs However, just like the best mattresses which is exactly why the ercol bed has remained on my wishlist rather than ending up in my bedroom even with a reduction from £1465 to £1172 for the double So imagine my excitement when I came across a Habitat alternative *and* it's now discounted in the Argos furniture sale from £400 to just £320 for the double there are some major differences between the two pieces of furniture Sign up to our newsletter for style and decor inspiration The ercol bed frame is crafted from solid oak whereas there's no mention of what type of wood the Habitat Chiltern bed frame is made from I would imagine it's very unlikely to be solid oak which means the ercol option is likely to be the stronger and more robust design the look of the Chiltern bed is achieved through veneers but that does mean there are more colour options available Habitat says that the Chiltern bed frame is made from FSC certified wood meaning the materials used for this product are responsibly sourced ercol not only ensures the wood used to make its furniture is FSC certified but also states it complies with UK Timber Regulations and has GIB (Grown in Britain) certifications This means timber is locally sourced which helps to keep the supply chain as short as possible with the ercol bed featuring a turned spindle top to the headboard and more tapered legs whereas the Habitat option features a curved top and bottom bar I think you could do a lot worse than considering one of these options I'm off to do some quick sums to see which one I'll be sleeping on in the foreseeable future She's spent the last four years researching and writing about what makes for the best night’s sleep during the day and testing out sleep products to find the best-in-class by night So far she’s clocked up over 10,000 hours of pillow she’s slept on and under bestselling products from Simba Amy is always on the lookout for the most breathable bedding but she also leads a wider team of testers to ensure our product testing encompasses both hot sleepers We have the address for the funeral home & the family on file If you're not happy with your card we'll send a replacement or refund your money Ada Maria (nee DiStefano) Sfamurri born in Teramo.- Italy on August 10, 1933, passed peacefully at home with her family by her side on Monday, December 4, 2023. A devout Catholic, she was a long-time member of St. Anthony&#8217;s Church. Her... View Obituary & Service Information The family of Ada Maria Sfamurri created this Life Tributes page to make it easy to share your memories Ada Maria (nee DiStefano) Sfamurri born in Teramo.-.. You can reach us 24/7/365 at (302) 731-5459 Copyright © 2025 Strano & Feeley Family Funeral Home and Crematory The Lasersoft Riccione scoreboard: Bologna 5, Calvelli 9, Tallevi 29, Gabellini 5, Morolli 6, Spadoni 12, Saguatti 4, Montrsi 1, Vidali L2, Calzolari L1, Chistè, Godenzoni, Gugnali ne, Tobia ne. Coach: Piraccini. The ranking: Bologna 52; Riccione 51; Vicenza 48; Cesena 44; Ravenna 40; Jesi 37; San Vendemiano and Padua 36; Giorgione 35; Castel D'Azzano 32; Forlì 28; Castelbellino 17; Eagles Mestrino 16; Teramo 8. The second victim of the Friday morning house fire has been identified as Davis Barbee Damonte Ranch Principal Darvel Bell sent a message to families this afternoon confirming the victim's name "Our Mustang counselors will be available for any student or staff in need of support," Bell wrote The Washoe County Regional Medical Examiner's office also identified Davis Barbee as a victim of the fire One of the two victims of an early Friday house fire in Reno has been identified died as a result of the fire at a single-family home in south Reno according to a message sent to parents Friday afternoon by Principal Kendra Smith "We are in communication with the family to provide our love and support," Smith said in the message adding that school counselors and other support resources were available for students and families "We are heartbroken over the loss of our Diamondback," she said The Washoe County Regional Medical Examiner's office also identified Travis Barbee as a victim of the fire Two people died in an early morning fire in a south Reno neighborhood on Friday Firefighters responded to reports of a house fire at 470 Teramo Ct Friday to fight what was described as an "extremely intense" fire at the two-story house The fire spread quickly and caused extensive damage Two of the home's occupants had escaped the fire and firefighters located two other occupants in the house who were transported to a local hospital by REMSA Health friends and neighbors impacted by this tragic incident,” Reno Fire Chief Dave Cochran said in a statement “The men and women of the Reno Fire Department acted swiftly and put forth an extraordinary effort to perform two rescues and extinguish this fire we join our community in mourning this terrible tragedy.”  The house was about 1.5 miles away from Fire Station No One firefighter also was transported to the hospital for burn-related injuries; other firefighters were treated on scene for minor issues stemming from the blaze The cause of the fire is under investigation. Those with information are asked to call the Reno Fire Department at 775-334-2300. They may also call or text Secret Witness at 775-322-4900 or visit secretwitness.com Bitter Winter A magazine on religious liberty and human rights Source: Italian Ministry of Justice.Recently delivered the ground of a decision rendered on January 26 in the case of a former Jehovah’s Witness who had sought the annulment of a decision by an ecclesiastical judicial committee to disfellowship him and damages for the physical and psychological problems allegedly derived from what disgruntled former members and anti-cult groups call “ostracism.” A local Jehovah’s Witness entered into a conflict with the organization He rejected the help that elders offered and after deciding not to appear before an ecclesiastical judicial committee He raised two claims against the Italian body of the Jehovah’s Witnesses The first was that in the procedure leading to its disfellowshipment his right to the defense which is also guaranteed by the European Convention on Human Rights The court observed that the Jehovah’s Witnesses in Italy are recognized as a religion by the State and that the Italian Supreme Court established in 1994 in a case concerning the Seventh-day Adventists that under Italian law “interfering with a religious organization is totally forbidden to the state.” that the Seventh-day Adventists have signed with Italy one of the concordats called “Intese” (the name “Concordato” is reserved to the agreement with the Roman Catholic Church) while in the case of the Jehovah’s Witnesses an “Intesa” has been signed by the government but “not yet” ratified by the Parliament the protection of religious organizations against any interference by the state in their internal matters derives from the Italian Constitution and exists even without an “Intesa.” Italian courts have sometimes decided that ascertain whether a religious organization did respect its own rules in internal judicial proceedings and guaranteed to the defendant the fundamental right of being heard these decisions also concluded that when the judiciary has to examine a matter pertaining to an ecclesiastical judicial system of a religious organization “it is enough that an essential core and respected it in the specific case that the court examined the defendant was invited to be heard at a hearing before a judicial committee and it was “his decision only” not to appear and defend himself The second claim by the former Jehovah’s Witness is that as a disfellowshipped member he suffered “ostracism” by his former friends which caused psychological and even physical damages and his wife not only filed for divorce but started several criminal cases against him based on the same principle of non-interference by the state in religious matters that secular judges “cannot rule on whether the principles taught by a religious confession are legitimate or otherwise.” the court noted that “notwithstanding the need to strike a balance between the freedom given to the association and the right of the individual member,… the judicial review should be agreed and limited to the protection of fundamental personal rights.” the plaintiff’s claim must be qualified as a claim for damages for unlawful conduct according to the tortious liability law On this point the judgment also referred to the principle set by the Italian Supreme Court of Cassation in its ruling no. 9561 the Supreme Court stated that “since the alleged ostracism was a refusal to associate with him [the plaintiff] as there is no law that requires a person to behave in the opposite manner no discrimination took place.” The Court of Cassation also stated that the fundamental personal rights “are certainly not undermined by the free choice of some individuals to break off or interrupt personal relations which do not have a legal protection.”   according to this legal framework and the general tortious liability law the judgement concluded that in the case the damages claim for “ostracism” could not be accepted the Court considered in detail the evidence of damages claimed by the plaintiff Regarding the divorce between the plaintiff and his spouse includes the freedom for a spouse to divorce for religious reasons and because the “spiritual communion” between husband and wife no longer exists As for the criminal cases filed by his ex-wife against the petitioner they concern the non-payment of the alimony and physical threats and abuse which have nothing to do with religion or ostracism but the court ascertained that they existed before his disfellowshipping which concluded that shunning can be freely taught and practiced in Belgium the negative decisions remain the expression of a minority view with respect to a larger corpus of international decisions which have all confirmed that interfering with the Jehovah’s Witnesses teachings on “ostracism” would violate both their religious liberty and the general principle that secular courts cannot interfere with how religions self-organize themselves the Court of Teramo added its voice to other Italian courts that followed the majority position že tato organizace už kvůli svému přístupu k bývalým členům nebude dostávat státní dotace a přijde o registraci Una testimonianza esclusiva documenta una tragedia “Bitter Winter” conosce la sua fonte e ha concluso che la storia è autentica et pädeval täiskasvanud patsiendil on õigus keeldu-da mis tahes ravist The idea of Turin as the capital of alternative spirituality was born in the 19th century with the flourishing in the city of “magnetizers” and “somnambulists.” CESNURVia Confienza 1910121 TorinoItalyinfo@bitterwinter.org Copyright © 2025 · Bitter Winter · PRIVACY POLICY· COOKIE POLICY An exhibition dedicated to Castelli’s famous ceramics: it is The Fragile Beauty Castellian Historiate between the Seventeenth and Eighteenth Centuries held at the Pinacoteca Civica di Teramo from December 18 after its reopening in 2018 and the subsequent publication of the relevant guide in 2021 intends to continue the work of enhancing the city’s historical and artistic heritage with this exhibition the first exhibition initiative set up in the renovated rooms curated by Giuseppe Matricardi and Stefano Papetti by presenting to the public a significant nucleus of castellan majolica from the seventeenth and eighteenth centuries that had remained confined to the deposits of the civic museum for long decades.The exhibition showcases the “fragile beauties,” or majolica tiles that came out of the ceramic workshops of Castelli a village in the province of Teramo that has imposed itself on the international scene thanks to the creation of ceramic artifacts characterized by daring experimental solutions and the reworking of images drawn from contemporary painting such as the pieces on display that stand out in thesphere of seventeenth- and eighteenth-century Italian production for the quality of the glazes enlivened by the application of gold the accuracy of the pictorial rendering and the adherence to the most up-to-date figurative repertoires of the time The ceramic tradition in the territory of Castelli apparently was already present in Etruscan times but in reality it is not possible to establish with certainty the origins of this art It is known that the earliest modern finds date back to the 15th century while it was from the second half of the 16th century that Castelli pottery came to prominence and reached its apogee becoming the most important economic activity in the village (and even today most of the inhabitants of Castelli which has just over a thousand inhabitants are employed in the pottery industry): Castelli pottery was widely popular as a quality product and decorated in very imaginative and lively styles The development of the art of ceramics is due to the fact that there are numerous clay quarries and several waterways around the village as well as beech forests that guaranteed wood to fuel the kilns which was used for landscapes or scenes with figures religious or mythological or even allegorical scenes The main characteristic of castellan historiato is the great vividness of the colors that have made it a particularly popular product since ancient times Between the 16th and 18th centuries there were a number of important family workshops active (those of the Grue Gentili and Pompei families in particular) which handed down the craft from generation to generation and often came to create products of artistic importance (think of the ceilings of the church of San Donato defined by Carlo Levi as the “Sistine Chapel of majolica”) Castelli’s ceramic production entered a decline in the nineteenth century due to changes in the trends of taste and competition from international porcelain Today a few potters’ workshops are still active passing on their knowledge at the family level The exhibition at the Pinacoteca Civica di Teramo displays a fairly homogeneous ensemble in terms of period and quality that mostly chronicles the style and artistic expression of Abruzzo’s most influential family of majolica makers and includes a devotional plaque depicting St.Anthony of Padua attributable to Liborio Grue a Holy Family of Cortonesque inspiration attributable to Candeloro Cappelletti and a series of plates with Arcadian landscapes in the style of Nicola Grue the Younger who belonged to a collateral branch of the family in order to better contextualize the importance and international notoriety acquired in the first decades of the 18th century by the artifacts made in Castelli the exhibition will take advantage of the contribution of some works from the Matricardi collection of Ascoli Piceno recently judged by Timothy Wilson as the most important private collection of Castellian majolica which was presented in Teramo in 2012 on the occasion of an exhibition that was fundamental to the development of studies on the activity of Abruzzo potters Municipally owned works will thus be flanked by plates and vases made by Carlo Antonio Grue whose figure has taken on extraordinary relevance thanks to the studies of Fernando Filipponi in the context of the artistic activities promoted by Pope Clement XI and his sons Aurelio Anselmo and Liborio with the ’intention of freeing from a condition of local phenomenon what was achieved by the Grue family thanks to family ties with the Dukes of Acquaviva and the Albani family is instead placed in a context open to the most up-to-date instances of European culture of classicist and Arcadian matrix that allowed the works that came out of their workshops to be contended by the most enlightened collectors of the 18th century In the exhibition this vocation to make majolica a first-rate artistic product is demonstrated by a series of precious artifacts destined for important personalities on the international political and cultural scene: this is the case of the four plates with Arcadian landscapes introducing Vetero and Neo Testament episodes placed in the background painted by Francesco Antonio Saverio Grue and enclosed within refined 18th-century carved and gilded wooden frames that declare their provenance from the Savoy royal collections; they belonged in fact to a sophisticated admirer of Rococo art such as Umberto II Also the series of admirable saucers painted with pastoral scenes attributed to Aurelio Anselmo and his brother Liborio Grue bearing the Testa-Piccolomini family coat of arms or the large plates with the heraldic insignia of Cardinal Ruffo show how in the eighteenth century the most important names of the aristocracy made use of what was painted in Castelli for the decoration of their homes the original function of use for these precious objects had been lost and they were considered rarities to be displayed in cabinets de curiositès or hung on the walls of refined rooms to be appreciated by a host of select connoisseurs now with the exhibition La fragile bellezza Istoriato castellano fra XVII e XVIII secolo (The Fragile Beauty Castellian Historials between the 17th and 18th centuries) we want to even more demonstrate how the skill of the Grue family’s artists had succeeded in the daring challenge of transforming a production technique born for the production of objects intended for domestic use into a true form of artistic expression The exhibition, with free admission, is open Tuesday through Sunday from 10 a.m. to 1 p.m. and 4 p.m. to 7 p.m. For information, visit the Teramo City Council website You don't have permission to access the page you requested What is this page?The website you are visiting is protected.For security reasons this page cannot be displayed Artist forced to cancel summer tour after being ‘charged at’ by woman at the end of concert The Italian singer Baby K has hit out against the “madness” of selfies and called for greater protection for artists after she was injured by a fan and forced to cancel the rest of her tour In a video posted on TikTok, she said she suffered “breast trauma” after being “charged at” by a woman at the end of a concert on Monday in Teramo, Italy as a crowd of fans surged around her for selfies The 40-year-old rapper and singer said she suffered breathing difficulties and was examined in hospital before being forced to cut short her summer tour “The most important thing for people is to take a photo but it has become very dangerous,” she said “I’m not complaining about taking pictures … but it’s getting out of hand accusing Italian police of poor crowd management whose real name is Claudia Nahum and who was born in Singapore Her most popular tracks include Roma Bangkok and Killer She has more than 730,000 followers on Instagram and the music video for Roma Bangkok has more than 300mviews on her YouTube channel around which the dual-density EPS liner is moulded The basic fit is reassuringly deep and instantly felt comfortable we loved the fine detents in the dial mechanism although we did find drips of sweat making it past the pads which is worth noting if you’re a heavy sweater Britain's Best Selling Road Cycling Magazine Associate Professor in Economics at the University of Teramo after a long and courageous battle against cancer She was a graduate of the University of Rome Tor Vergata in 2008 where she also received her BA and MS in 2003 and 2004 Before joining the Department of Political Science at the University of Teramo in 2019 she had multiple experiences of research and work in Italy and abroad After starting her career as an intern at the United Nations Industrial Development Organization in Amman (Jordan) she has been a Visiting Scholar at the Center for Health Policy at Stanford (USA) and a Research Analyst at Acumen LLC she became a Research Fellow both at the Centre for International Health and Development of University College London (UK) and at the Department of Economics and Management of LUISS University (Italy) in 2008 and 2009 she was appointed Assistant Professor at the Department of Economics she served as a consultant for the Food and Agriculture Organization of the United Nations (FAO) Noemi contributed to more than 50 publications and has given more than 40 lectures at national and international conferences One of her main focuses was the study of decision-making by individuals and its consistency with the basic principles of economics and game theory through the use of laboratory experiments with applications especially to health topics Her work in this area has been particularly rich among others: human behaviour under ambiguity a situation in which probabilities do not exist or the decision-maker does not know actual probabilities; the behavioural patterns contributing to the improvement of individuals’ suboptimal choices; the role played by learning and advice in reducing suboptimality for risk-neutral subjects Some of Noemi’s laboratory experiments were conducted with Daniela Di Cagno Professor of Economics at LUISS University “We will never forget her grace and her clever and independent way of thinking,” says Di Cagno Another important stream of her analysis looked at the economic impacts of social protection programmes across sub-Saharan Africa Her work contributed to increasing FAO’s international standing in the realm of evidence-based policy dialogue and informed the design of these programmes This includes research on the effectiveness of labelling and messaging for influencing the use of cash transfers; on the synergies that can be achieved by combining agricultural and social protection interventions; and on the role of social protection in encouraging livelihood diversification risk-taking and women’s economic inclusion She also provided invaluable technical advice and guidance on evaluation and quantitative assessment for several FAO projects in other regions and helped to shape FAO's research agenda on social protection committing to the highest intellectual standards Noemi will be remembered not only for her scientific and professional brilliance her dedication to work and commitment to the institutions she worked for but also for her kindness and human warmth “Noemi willingly engaged with and supported colleagues of all levels and did not hesitate to go the extra mile to coach them,” Kangasniemi says “Friends and colleagues also remember her as a wonderful conversationalist You currently use an outdated internet browser. You can upgrade to a modern browser or use the Google Chrome Frame to optimize your viewing experience While that may not apply to all the towns out there, it surely does to Teramo, Italy, where SO.CA.BI. SpA has partnered with HUB Italia to renew the multi-storey underground parking lot in Piazza Dante The car park serves citizens and businesses nearby providing a high level of service through LPR and digital technology The new integrated access control and parking regulation system is an exemplary deployment of 4.0 technology. Through JMS tile-based dashboard The modular configuration of the system results in reduced energy costs to deploy a strong focus on the environmental impact produced by operational processes Another successful project by HUB Italia: kudos to the team HUB Parking Technology is the Business Unit of the FAAC Technologies that develops software and intelligent mobile solutions produces and supplies hardware and after-sales services for the professional management of paid parking spaces and widespread assistance at a local level and strength of a global operator – through local offices and authorized distributors the company has constantly innovated to develop state-of-the-art systems and integrated value-added solutions that make parking efficient for users For more information about HUB Parking Technology, visit:  www.hubparking.com Your email address will not be published. Required fields are marked * Save my name, email, and website in this browser for the next time I comment. By submitting this form you agree that this site stores and manages your data. You also agree to our privacy policy and to receive emails according to the preferences you have expressed. Remember that you can unsubscribe or change these at any time. Agustin, Patricia and their two children are an Argentinian family. After following a course at Sophia ALC, the Latin-American branch of the university institute that is based in the international little town of Loppiano (Italy), they began to research their roots among the indigenous peoples, and this gave rise to a strong commitment in intercultural dialogue. The 2025 edition of the traditional youth festival in the Focolare citadel If you would like more information or to get in touch with us, please send us your details. By submitting this form you agree that this site saves and manages your data. BOLOGNA (Lega Basket) – Fortitudo Bologna failed in their bid to avoid relegation after the Federal Court rejected their appeal to have last weekend’s game against Teramo replayed.\r\n\r\nFollowing their one-point defeat to Teramo, Fortitudo argued they had two baskets incorrectly waved off, claiming the precision time equipment had malfunctioned. ... Following their one-point defeat to Teramo Fortitudo argued they had two baskets incorrectly waved off claiming the precision time equipment had malfunctioned Registration has been successfully completed Make a new account if you don't have one yet Puedes ver la versión Española de BeSoccer.com You can see the English version of BeSoccer.com Vous pouvez voir la version French de BeSoccer.com Puoi vedere la versione Italian su BeSoccer.com Você pode ver a versão Brasileira de BeSoccer.com The INGV Seismic Room where they are analyzed in time the data of all the Italian earthquakes is real INGV immediately started the second and third phases which include the Italian Seismic Bulletin and the most advanced processing with the aim of improving the results useful for emergency management and for the population in general these elaborations translate into new or different results but in any case more accurate than the elaborations carried out in real time these results will be made public in the next few hours and in any case as soon as they are available Link to the INGVterremoti Blog The contents published on these pages by theNational Institute of Geophysics and Volcanology are distributed under license Creative Commons Attribution 4.0 International License.