image: Cacio e pepe is an iconic pasta dish that is also frustratingly difficult to make A group of Italian scientists studied what makes it fall apart to better understand how to make it more reliably 2025 – The beloved Italian pasta cacio e pepe is perhaps best known for two things: being delicious and being frustratingly difficult to cook But as anyone who has tried to make it will know the cheese will often clump when added to the hot pasta water researchers from the University of Barcelona the Max Planck Institute for the Physics of Complex Systems and the Institute of Science and Technology Austria studied the physics of mixing cheese in water They determined the mechanism that causes the cheese sauce to go from creamy to clumpy and developed a foolproof recipe for cacio e pepe based on their findings their work was about more than idle curiosity “We are Italians living abroad,” said author Ivan Di Terlizzi “We often have dinner together and enjoy traditional cooking Among the dishes we have cooked was cacio e pepe and we thought this might be an interesting physical system to study and describe there was the practical aim to avoid wasting good pecorino.” The team first focused on the starch in the pasta water as the key ingredient for a perfect sauce fatty substances like cheese cannot mix with water but a stabilizer like starch helps to bridge that gap the researchers found that a 2%-3% starch-to-cheese ratio produced the smoothest The other key element of a perfect cacio e pepe sauce is heat — or rather Too much heat denatures the proteins inside the cheese causing them to stick together and leading to the dreaded clumps the authors advise letting the water cool before mixing in the cheese and bringing the sauce up to temperature as slowly as possible For those looking to make cacio e pepe at home the team provided a scientific recipe for making a perfect sauce The first step is creating some starchy water they recommended using powdered starch like potato or corn starch rather than relying on an unknown amount of starch in pasta water “Because starch is such an important ingredient and the amount of starch can sharply determine where you end up what we suggest is to use an amount of starch which is precisely measured,” said Di Terlizzi “And this can only be done if you have the right amount of powdered starch in proportion to the amount of cheese that you're using.” the authors’ instructions say to blend it with the cheese for a uniform consistency before adding the sauce back into the pan and slowly heating it up to serving temperature the final steps are to mix in the pepper and pasta the researchers have an entire pantry full of ideas “There's a recipe called pasta alla gricia cured pork cheek,” said author Daniel Maria Busiello “This recipe seems to be easier to perform This is one idea we might explore in the future.” The article “Phase behavior of cacio e pepe sauce” is authored by Giacomo Bartolucci, Daniel Maria Busiello, Matteo Ciarchi, Alberto Corticelli, Ivan Di Terlizzi, Fabrizio Olmeda, Davide Revignas, and Vincenzo Maria Schimmenti. It will appear in Physics of Fluids on April 29, 2025 (DOI: 10.1063/5.0255841). After that date, it can be accessed at https://doi.org/10.1063/5.0255841 Physics of Fluids is devoted to the publication of original theoretical, computational, and experimental contributions to the dynamics of gases, liquids, and complex fluids. See https://pubs.aip.org/aip/pof 10.1063/5.0255841 are not responsible for the accuracy of news releases posted to EurekAlert by contributing institutions or for the use of any information through the EurekAlert system Copyright © 2025 by the American Association for the Advancement of Science (AAAS) EngineeringStefano Terlizzi joins nuclear engineering department at Penn StateStefano Terlizzi joined the Ken and Mary Alice Lindquist Department of Nuclear Engineering as the John and Jean M Brennan Clean Energy Early Career Professor on July 22 UNIVERSITY PARK, Pa. — Stefano Terlizzi joined the Ken and Mary Alice Lindquist Department of Nuclear Engineering as the John and Jean M Terlizzi talks about his research background and interests What significance do these areas have for the average person or what are some of the well-known applications of these research fields Terlizzi: My research focuses on developing novel computational methods to improve the speed and accuracy of nuclear reactor analysis These methods enable the creation of high-fidelity models of advanced reactors which can be applied to optimize reactor design The increased fidelity allows for a deeper understanding of the underlying physics that governs advanced nuclear reactor systems It also allows for the creation of digital twins — virtual models of real-world systems that can be used to simulate particular situations — for optimizing design and enhancing economic competitiveness The cutting-edge analysis and optimization methods developed by my group are applicable to both standard nuclear reactors and for reactors intended for space exploration and colonization Q: What is your professional background leading up to joining Penn State I spent three and a half years at Idaho National Laboratory (INL) first as a distinguished postdoctoral fellow and then as a staff scientist I led several projects focused on advanced reactor analysis and design This included work on hydrogen migration in hydride-moderated microreactors as well as developing new analysis tools for NASA and the Nuclear Regulatory Commission (NRC) I completed my doctorate at Georgia Tech in 2020 where my research focused on creating a novel method for faster and more robust coupled-neutronics and thermal-hydraulics calculations I earned both my bachelor of science and master of science in energy and nuclear engineering from the Polytechnic University of Turin in Italy What are you most looking forward to as you join the faculty in the Department of Nuclear Engineering Terlizzi: I was drawn to Penn State because the Ken and Mary Lindquist Department of Nuclear Engineering is one of the top-ranked programs in the country with significant potential for growth due to its strong collaborations with national laboratories and industries active in the advanced nuclear reactor space fostered by an excellent balance of senior and junior faculty provides a unique environment for pursuing innovative research and advancing the field Penn State ranks fourth nationally in the number of undergraduate nuclear engineering degrees awarded annually reflecting its commitment to education and the next generation of nuclear engineers I'm excited to contribute to this dynamic community and look forward to exploring new research opportunities and working closely with students and faculty alike Q: What are some of your ongoing projects or some upcoming projects that you are excited about Terlizzi: One of the projects I’m excited about is applying my expertise in fission reactors and computational methods to advance high-fidelity tools for nuclear reactor analysis and design I aim to leverage novel modeling techniques to minimize the cost of nuclear reactors and accelerate their deployment by using design optimization tools By integrating economic and technical considerations from the early design stages these tools can streamline the development process ensuring that reactor designs are both economically viable and highly efficient ultimately supporting broader adoption and commercialization of nuclear technologies Another area I’m enthusiastic about is exploring the potential transition from “micro-reactors” to “nano-reactors.” The goal is to determine how much we can reduce the size of a nuclear reactor for a given power output we will investigate fuel in the form of triply periodic minimal surface (TPMS) lattices These lattices consist of intertwined volume domains separated by a minimal surface TPMS structures have gained attention in various engineering fields including heat exchangers and nuclear engineering due to their topology-driven thermal properties TPMS-based lattices can only be produced through additive manufacturing While some preliminary studies have focused on characterizing TPMS unit cells no research has yet analyzed a full reactor core using TPMS My group’s research aims to fill this gap by exploring the feasibility of creating extremely compact reactors leveraging the superior heat dissipation of TPMS structures Q: What is your research group’s area of focus Do you have research opportunities for graduate or undergraduate students with a focus on applying validated models to create digital twins of reactor systems for optimization and design purposes We have a variety of research opportunities for both graduate and undergraduate students who are interested in these topics and want to contribute to advancing nuclear reactor analysis and technology. Email me at sbt5572@psu.edu if you are interested in joining our group or if you are interested in collaborating with us This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page There are no statistics available for this player Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here By Martie Thompsoneditor@floridanewsline.com Joseph’s Catholic Church as director of the church’s popular monthly Bingo games He graduated from Staten Island Community College and began his medical career as an EMT stationed in the Bronx He went on to work at the public health hospital in Staten Island before being lured away by what would become a successful career in the car business After 29 years working at a dealership in New Jersey he and his wife Eileen had the opportunity to move to Clearwater for a similar job A job offer from Coggin Nissan brought the Terlizzi family to Jacksonville where they have remained despite Vincent being out of the car business now for a number of years but is passionate about serving his church with the Bingo event and also at the Christmas tree lot He and his wife Eileen have two grown children Q: How did you get into the car business?A: I was working at the hospital when I bought a car from Autoland in Springfield They had a referral program and I referred so many people to them that the owner asked me to work for him so I took my two weeks vacation from the hospital and tried out working full time at the dealership In those two weeks I made the same amount of money that I would have made in three months at the hospital So I went back to the hospital and gave my two-week notice I soon became the youngest finance department director in the car business in New Jersey.  Q: What do you think made you so successful?A: Customer service is so important We never had any complaints in our department I liked to hire young salespeople and mentor them Some of them own dealerships today and many still keep in touch with me Q: How did you meet your wife?A: Eileen also worked in the car business I was trying to get a particular bonus and needed to have three applications processed by her before midnight I went over her head and called her boss and talked him into accepting the contract which was for a conversion van for a doctor’s family A couple of days later I asked her to lunch to apologize for going over her head to her boss Although I did have to call her boss back after lunch and tell him he needed to take her off my account since now that we were dating it would be a conflict of interest Q: How did you end up in Florida?A: Unfortunately the owner of Autoland eventually passed away The new managing team fired a lot of the salespeople and we went from selling 1,000 cars a month to 600 cars a month in just two months They wanted me to stay and I did for a little while but if the salespeople weren’t selling cars I didn’t have as much opportunity for work went to Clearwater and eventually came here to Jacksonville.  Q: What is it that you enjoy about Bingo?A: I actually volunteered at Bingo back at my church in New York but eventually we got a new priest and he approved it We had our first event in 2019 with about 60 people but our biggest event was last July when we had attendance of 360 But all of us who work there are volunteers we plan to have a special (additional) Bingo event to benefit St [Editor’s Note: Bingo is hosted monthly at St Joseph’s Catholic Church in the Cody Center at 4152 Loretto Road Contact vaterlizzi@gmail.com for dates and more information.]  Photo courtesy Vincent TerlizziVincent and Eileen Terlizzi Learn how to describe the purpose of the image (opens in a new tab) Leave empty if the image is purely decorative The classic Italian cacio e pepe pasta is notoriously tricky to get right but physicists have come up with a trick to achieve a perfectly smooth cheese sauce By Alex Wilkins Spaghetti cacio e pepe is made with black pepper and pecorino cheese Physicists have discovered the key to a consistently delicious cacio e pepe pasta a traditional Italian dish made with black pepper and pecorino cheese Cooking cacio e pepe involves melting the cheese with some of the water the pasta is cooked in to create a smooth sauce If the mixture becomes too hot or has the incorrect balance of cheese and starch from the pasta water then the sauce will become unpleasantly lumpy rather than smooth Read more Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application 2024 with the family she loved gathered at her side.  Michelena was born in Worcester the daughter of Joseph and Mary (Oliveri) Mazzone she graduated from Commerce High School and married the love of her life Silvio Terlizzi dedicated to raising their children with love For many years Michelena worked alongside her husband operating Silvio’s Flamingo Restaurant on Shrewsbury Street After retiring from the restaurant business she accepted an administrative  position at the University of Massachusetts Medical School Department of Student and Employee Health until her retirement.  Michelena is survived by her four children and sisters Antoinette Palermo and Carmela Santoro predeceased her.  Michelena was an avid reader and an accomplished seamstress who frequently made all types of clothing for her extended family she enjoyed going to Mass and Novenas with her sisters She also enjoyed entertaining her friends and family and cooking for holidays and special occasions Her greatest joy was being with her family.  A period of calling hours will be held Saturday March 16th from 12 -1 PM in the Notre Dame du Lac Chapel  Her funeral Mass will follow at 1 PM celebrated by family friend Monsignor Stephen Pedone March 18 at 9 AM.  In lieu of flowers memorial remembrances in her name can be made to Notre Dame du Lac Assisted Living Center 370 Plantation St is honored to assist the family with arrangements Notre Dame Du Lac Chapel 555 Plantation St Worcester Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors A Linden man who was intoxicated when he struck and killed a Cumberland County Sheriff's deputy in 2022 will was sentenced to up to eight years in prison last week after pleading guilty in the case Nicholas Terlizzi, 25, of Linden, pleaded guilty to felony death by a vehicle and felony hit-and-run for the Dec. 16, 2022, death of Deputy Oscar Yovani Bolanos-Anavisca Jr. no liability insurance and expired registration were dismissed Terlizzi was given credit for 18 months spent in jail awaiting trial Bolanos-Anavisca was fatally struck at 2:46 a.m near Dedication Drive as he and his law enforcement K-9 walked back to the deputy's patrol car after participating in a search for a robbery suspect Bolanos-Anavisca was pronounced dead at Cape Fear Valley Medical Center Related: 'Oscar paid the price': Man to face murder charge in Cumberland County deputy's death 301 and State Highway Patrol troopers noted damage to the BMW SUV he was driving was consistent with the impact Court records state that Terlizzi had red glassy eyes Assistant District Attorney Rob Thompson said Terlizzi's blood alcohol level of 19 was more than double the legal limit for driving family and law enforcement officers grieved the loss of the deputy spoke about the man she was ready to marry and whom she began dating when the two were just 15 “You were more than a deputy to me,” Schmidt said My heart is broken knowing that our time together has been cut so short.”   Bolanos-Anavisca's death marked the first time in 18 years that a Cumberland County deputy died in the line of duty Public safety reporter Joseph Pierre can be reached at jpierre@gannett.com Not when there were five minutes left and her team led by eight goals But Jillian Terlizzi’s fantastic save on Pine Bush’s Mackenzie Brown who was on her doorstep when she unleashed a bullet shot off a perfect feed epitomized how Wednesday’s Class A girls lacrosse state regional semifinal went Suffern erased a 2-1 deficit after one quarter in a huge way That lopsided score had a lot to do with how Terlizzi played How she denied multiple 8-meter free shots ones that are often regarded as close to gimmes fellow Suffern junior Molly Mitchell was also having a great time the Section 9 Bushmen finished the season 14-5 at Queensbury High School against Section 2 Saratoga Springs in a regional final with a trip to the state Class A semifinals on the line Who scored and howFiona Varley and Samantha Budney scored in the first quarter for the Bushmen and Charlotte Ullman had the Mounties’ first-quarter score But from the opening minute of the second quarter on Mitchell scored four times in that quarter Her most impressive goal might have come off her bullrush from behind the net out in front where she was jostled by Pine Bush’s D but couldn't be stopped That was a few minutes after Terlizzi saved a couple of Pine Bush 8-meter tries Suffern scored two of its six second-quarter goals in the last 19 seconds of the quarter with Mitchell appearing to use Pine Bush’s defense as a screen to score before Caitlin Ruggiero put a shot home off a Michaela Fay feed with four seconds remaining But it didn’t stay that way for long as the third quarter opened with more of the same The ball was awarded to Pine Bush off the next draw and the Bushmen came up with an excellent scoring chance only to have Terlizzi once again deny them Terlizzi then denied Pine Bush senior Kathryn Cragan a couple of times and Suffern’s defense knocked the ball away on an 8-meter free play Brown eventually scored for the Bushmen but the third quarter would end with Suffern up 10-3 Terlizzi would put on more of a show early in the fourth quarter with a fantastic save off an 8-meter before appearing to get a piece of a follow-up rebound try that deflected wide Sophia Licardi finished out the scoring for Pine Bush on a hard one-hopper off an 8-meter to cut the Suffern lead to lead to 11-4 with 8:21 left Suffern proved to have too many weapons as a minute later Daniela Trubiano hit Ruggiero with a well-timed pass and Ruggiero put it n over Pine Bush keeper Grace Grant A great stop by Terlizzi on Brown followed Grant finished with six saves for Pine Bush Ruggiero had two goals for Suffern and the lengthy list of those with one goal included Michaela Fay (who also had an assist and whose speed proved a problem for Pine Bush) who’ll play next year for Stetson after a six-year varsity career at Pine Bush was at a loss to explain what had happened to her team after a solid first quarter noting her team had never reached this level of the postseason before “I feel like everyone is so proud to get so far It’s a sad ending but a good ending together.” Section 1 Class A title game: Suffern stalls for 10 minutes to defeat Wappingers in lax section final Terlizzi pointed to Suffern’s slow start as a bit typical but indicated after the first quarter her team was of a different mindset “We knew we just had to have fun and leave it on the field (Pine Bush) came out a lot stronger (at the start of the game) but we picked it up,” she said She in part credited Suffern’s conditioning for the win We tend to tire (other teams) out and wear them out,” she said Nancy Haggerty covers cross-country, track & field, field hockey, skiing, ice hockey, basketball, girls lacrosse and other sporting events for The Journal News/lohud. Follow her on Twitter at @HaggertyNancy Find tour dates and live music events for all your favorite bands and artists in your city BOSTON (CelebrityAccess) — Up-and-coming Italian rock and jazz artist/composer Matteo Mancuso has signed with The Kurland Agency who will rep him for bookings in North America The son of well-known Sicilian guitarist and producer Vincenzo Mancuso Matteo began performing in local festivals when he was just 11 including the Castelbuono Jazz Festival in Sicily and the Umbria Jazz Festival in Perugia in 2017 paying homage to his musical and cultural roots as well as the artists and genres that have helped to shape his art He will be represented at TKA by Jamie Ziefert New Artist Signings Find tour dates and live music events for all your favorite bands and artists in your city! Get concert tickets, news and more! 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Get the best and latest industry news, data, new artist signings, insider commentary and more, delivered right to your inbox! 1962Following93Follow9393 FollowersJP Terlizzi ( American 1962 ) is a New York City photographer whose contemporary practice explores themes of memory His images are rooted in the personal and heavily influenced around the notion of home Pamela Terlizzi I’ve had a daily meditation practice for years but over the past few months I have made it a point to practice 10-15 minutes of resonance frequency breathing in the morning before I start the day I set a timer and count my breathing: 5 counts inhale and 5 counts exhale I already knew the benefits of meditation and breathing through my yoga practice but it wasn’t until I read the book Breath by James Nestor that I understood the physiological benefits of regular breathwork Then I read a couple of compelling scientific studies about the health benefits of resonant frequency breathing and was convinced it was a habit I needed to incorporate into my life Thus my morning meditation practice shifted to a morning breathwork practice.  I can honestly say that I wake up and look forward to my breathwork It’s a familiar habit now and one that I can take with me wherever I go I feel discombobulated and lack a sense of clarity for the day After months of regularly practicing resonance frequency breathing I’m much more aware of my breath and heart rate I also notice that my breathing is much more relaxed during the day; I don’t hold my breath or strain to breathe.  Breathwork is also a great tool to practice at work I host weekly “mini meditation breaks” for my customer’s employees every Tuesday at 9:30 a.m We meet on a virtual call to practice a 5 minute meditation and I utilize guided meditations available through their EAP program to lead us in practice but it gives us something to connect about that is not work-related My well-being philosophy is to start simple and practice small steps most straightforward healthy habits are often the ones that make the most impact: drinking plenty of water and learning to be still and enjoy a moment of quiet Wellness Consultant with Plan Sponsor Insights supporting a National Account will serve a year in the Branch County Jail then five years probation after he pleaded no contest to child abuse second degree Joseph County Prosecutor John McDonough said of the young 13-year-old girl victim “this young girl was put into a position that was horrible The teen told Branch County Circuit Judge Bill O’Grady “He touched me Terlizzi must not be within 500 feet of the girl or have any contact with children under the age of 17 without permission of his probation officer The resolution is appropriate to the situation.”  McDonough agreed to the plea which will not require Terlizzi to register as a sex offender but will require him to be placed on the state registry as a child abuser Terlizzi wanted to go to trial but if convicted of the original charge of third degree criminal sexual conduct The 13-year-old said Terlizzi sexually abused her in Aug 2018 in a Girard Township home where they both were staying There were several other people sleeping in the room A girlfriend of Terlizzi claimed Terlizzi would have had to reach over her in bed to get to the girl who was sleeping on the floor in the same bedroom A video statement by Terlizzi where he said he had touched the girl on the thigh was considered ambiguous by the court during a preliminary examination A former jail cellmate was prepared to testify against Terlizzi He testified that Terlizzi made a statement to him in jail that he had pulled the girl over to him and put his hand in her pants Terlizzi will serve another month and a half receiving credit for 60 days good time and 256 days already served McDonough was appointed to prosecute the case because former Prosecutor Ralph Kimble knew the Terlizzi family Partly cloudy early followed by cloudy skies overnight Former North Augusta High School principal Richard Terlizzi has been arrested again this time on a shoplifting charge in Aiken who was the school’s principal for three years prior to his resignation and arrest in 1998 was jailed on June 27 by the Aiken Department of Public Safety was charged in 1998 with embezzlement of public funds after North Augusta Public Safety apparently became aware of misappropriation of $1,000 during an audit Terlizzi had been a principal in the South Carolina Department of Juvenile Justice Scott Rodgers is the news editor at The North Augusta Star and has been with the paper since 2013 Filled with beds, dressers, tables and chairs, Savvy Home's new location opened Friday, and its owners are looking to make personal connections in North Augusta. Read moreSavvy Home opens its doors in North Augusta North Augusta is home to the Meriwether Monument — erected in 1916 — that honors the sole white man who died in the race-related Hamburg Massacre that claimed eight lives. Read moreWhat is the Meriwether Monument in North Augusta? Kindness wen… Read moreGas giveaway sparks kindness campaign in North Augusta I’m a member… Read moreDo you remember pink sugar cubes? Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Volume 8 - 2017 | https://doi.org/10.3389/fmicb.2017.01566 Urinary tract infections (UTIs) are one of the most common pathological conditions in both community and hospital settings It has been estimated that about 150 million people worldwide develop UTI each year with high social costs in terms of hospitalizations and medical expenses Among the common uropathogens associated to UTIs development UroPathogenic Escherichia coli (UPEC) is the primary cause UPEC strains possess a plethora of both structural (as fimbriae iron-acquisition systems) virulence factors that contribute to their capacity to cause disease although the ability to adhere to host epithelial cells in the urinary tract represents the most important determinant of pathogenicity the bladder epithelium shows a multifaceted array of host defenses including the urine flow and the secretion of antimicrobial substances which represent useful tools to counteract bacterial infections The fascinating and intricate dynamics between these players determine a complex interaction system that needs to be revealed This review will focus on the most relevant components of UPEC arsenal of pathogenicity together with the major host responses to infection the current approved treatment and the emergence of resistant UPEC strains the natural antimicrobial compounds along with innovative anti-adhesive and prophylactic approaches to prevent UTIs Escherichia coli adhesins and harboring/motile structures which are involved in reversible switching between ON-OFF Phases are strictly regulated by environmental signals within the urinary tract such as acidic pH and salt growth conditions On the other hand, UPEC toxins play different pathogenetic roles during infection. The α-hemolysin is in fact associated with renal damage and scarring, induces Ca2+ oscillations in renal tubular epithelial cells, thereby potentially enhancing ascension and colonization of ureters and kidney parenchyma by disrupting the normal flow of urine. Recently (Nagamatsu et al., 2015) α-hemolysin was found to induce proinflammatory Caspase-1/Caspase-4-dependent cell death in bladder epithelial cells upregulate genes for the transferrin receptor and for lipocalin 2 The importance of the above described UPEC virulence factors in UTI pathogenesis has been further supported, in recent years, by the application of multiple “omics” technologies aimed at investigating the UPEC genomic diversity, the global gene expression in different models of infection both in vitro and in vivo, and to define the occurrence of UPEC-specific proteins as new candidate therapeutic and vaccine targets (as recently reviewed by Lo et al., 2017) all the above mentioned “omics” approaches have allowed a great deal of new information to be available and that is enabling a more comprehensive understanding of UPEC's pathogenic mechanisms The innate immune responses of bladder epithelium to bacterial infections (A) The bladder epithelium; (B) adherent bacteria are internalized along with Rab27b+ fusiform vesicles; (C) exocytosis of RAB27b+ vesicles harboring UPEC and expulsion of the intracellular UPEC back into the lumen of the bladder; (D) transient receptor potential mucolipin 3 Ca2+ channel (TRPML3) triggers the spontaneous expulsion of the defective lysosomes and its contents out into the extracellular space; (E) soluble factors are also secreted by BECs such as cathelicidin and β-defensin 1) antimicrobial proteins [such as pentraxin 3 (PTX3)] and chemokines [such as CXC-chemokine ligand 1 (CXCL1) and CC-chemokine ligand 5 (CCR5)] (F) Exfoliation is accompanied by rapid renewal of superficial BECs through active proliferation of basal progenitor mast cells Intimate crosstalk between macrophages ensures the precise initiation of neutrophil responses because internalized bacteria are mostly encased in Rab27b+ compartments New antibiotics, such as colistin (Cui et al., 2016), finafloxacin, and cefiderocol (S-649266), which are currently in early clinical development, might be useful in the treatment of UTIs (Zacché and Giarenis, 2016) Figure 4 shows the structure formulae of the most representative antibiotics for which UPEC resistance has been demonstrated (red background) and those showing susceptibility to UPEC (green background) The yellow background shows antibiotics that already show resistance in some UPEC strains Structure formulae of some UPEC resistant and susceptible antibiotics UPEC resistance is shown with a red background whereas the yellow background shows antibiotics that already show resistance in some UPEC strains Antibiotics will continue to be an unavoidable source for the prevention of UTIs on a case-by-case basis the excessive use of antibiotics and the long-term interference with intestinal microbiota require to search for alternative remedies A plethora of molecules has been tested to reduce UPEC infections by exploiting their ability either to stimulate the immune system or to interfere with the UPEC ability to adhere and invade the urothelium Here we briefly summarize the most effective alternative remedies to fight UPECs thus suggesting some sort of indirect-cooperative function Figure 5 depicts the chemical structure of some pilicides and curlicides Structure formulae of D-mannose and some bioactive mannosides Structure formulae of methenamine mandelate and hippurate Phenolic compounds exert a strong antibiotic effect and can be generally subdivided into polymeric and not polymeric phenolics further studies are necessary to dissect the role of PAC-A in UTIs reduction Structure formulae of some polymeric phenolics Green tea extracts are also rich in polyphenols, with catechins (Figure 9) being the most active components. The antimicrobial activity of green tea against UPEC was correlated to the ability of catechins to be excreted in the urine at concentrations enough to reduce the UTI (Reygaert and Jusufi, 2013), and this hypothesis was confirmed by intravescical instillation on a rat model of bacterial cystitis (Rosenberg et al., 2014) Structure formulae of some non-polymeric phenolics Other non-polymeric phenolic exert antiadhesive properties. Trans-cinnamaldehyde is able to down-regulate the expression of some UPEC genes involved in attachment and invasion of host tissue. This compound was found to significantly decrease UPEC attachment and BECs invasion (Amalaradjou et al., 2011) Plant extracts with antimicrobial/antiadhesive activity against UPEC Figure 11 shows the structure formulae of some bioactive compounds against UPEC listed in Table 1 Figure 11. Structure formulae of some representative bioactive compounds isolated from plant extracts exerting antimicrobial activity against UPEC listed in Table 1 Uropathogenic Escherichia coli infections pose a serious problem to human health with societal costs of tens of billion US$ worldwide The increased resistance to both synthetic and natural antibiotics causes recurrence and chronicity of infection with the emergence of new and more serious illnesses There are both direct and indirect strategies against UPEC infections Direct strategies are targeting bacteria viability bladder epithelium adhesion and biofilm formation; indirect strategies elicit and enhance immune responses by stimulating infected tissues and cells to overreact to UPEC invasion An increasing body of evidence shows that reduction of adhesion of UPEC to urinary tract tissues reduces recurrence and increases recovery Future interesting targets might not only be directed to UPEC adhesins but also to immune-based strategies able to improve cell responses to UPEC infection; in this context several natural products fit this strategy The four main areas representing the Strengths and the Weaknesses of UPEC the Opportunities for alternative remedies to antibiotics and the Treats that UPEC cause to human health The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The publication of this work was supported by the University of Turin local research funds to MT Pilicides - small molecules targeting bacterial virulence The nature of immune responses to urinary tract infections Lipopolysaccharide domains modulate urovirulence placebo-control led trial of a herbal medicinal product containing Tropaeoli majoris herba (Nasturtium) and Armoraciae rusticanae radix (Horseradish) for the prophylactic treatment of patients with chronically recurrent lower urinary tract infections Trans-cinnamaldehyde decreases attachment and invasion of uropathogenic s in urinary tract epithelial cells by modulating virulence gene expression Common questions about recurrent urinary tract infections in women Variation in endogenous oxidative stress in Escherichia coli natural isolates during growth in urine PubMed Abstract | Google Scholar Treatment of urinary tract infections and antibiotic stewardship CrossRef Full Text | Google Scholar Nonantibiotic prophylaxis for recurrent urinary tract infections: a systematic review and meta-analysis of randomized controlled trials In vivo mRNA profiling of uropathogenic Escherichia coli from diverse phylogroups reveals common and group-specific gene expression profiles Role of uropathogenic Escherichia coli virulence factors in development of urinary tract infection and kidney damage More than just a barrier: urothelium as a drug target for urinary bladder pain Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells PubMed Abstract | CrossRef Full Text Persistence of uropathogenic Escherichia coli in the face of multiple antibiotics Chaperone–usher pathways: diversity and pilus assembly mechanism A novel two-component signaling system facilitates uropathogenic Escherichia coli's ability to exploit abundant host metabolites Proteomic analysis of uropathogenic Escherichia coli Small-molecule inhibitors target Escherichia coli amyloid biogenesis and biofilm formation and assembly of adhesive organelles by uropathogenic bacteria Antibacterial activity of medicinal plant Crateava nurvala (bark) against bacterial strains causing urinary tract infection Google Scholar Use of cefuroxime for women with community-onset acute pyelonephritis caused by cefuroxime-susceptible or -resistant Escherichia coli Role of Escherichia coli curli operons in directing amyloid fiber formation Loss of bladder epithelium induced by cytolytic mast cell granules Synthesis and application of a bromomethyl substituted scaffold to be used for efficient optimization of anti-virulence activity The role of the antimicrobial peptide cathelicidin in renal diseases Chrubasik-Hausmann Proanthocyanin content in cranberry CE medicinal products Variability of commercial cranberry dietary supplements for the prevention of uropathogenic bacterial adhesion Broad spectrum antibacterial activity of a mixture of isothiocyanates from nasturtium (Tropaeoli majoris herba) and horseradish (Armoraciae rusticanae radix) Prevention of recurrent acute cystitis by methenamine hippurate - double-blind controlled crossover long-term study Disruption of membrane by colistin kills uropathogenic Escherichia coli persisters and enhances killing of other antibiotics Treatment and prevention of urinary tract infection with orally active fimH inhibitors Prospective cohort study of microbial and inflammatory events immediately preceding Escherichia coli recurrent urinary tract infection in women Risk assessment of free hydroquinone derived from arctostaphylos uva-ursi folium herbal preparations Binding and neutralization of lipopolysaccharides by plant proanthocyanidins Detection of antibacterial compound of Avicennia marina against pathogens isolated from urinary tract infected patients CrossRef Full Text | Google Scholar Mechanisms and consequences of bladder cell invasion by uropathogenic Escherichia coli Botanicals and their bioactive phytochemicals for women's health Treatment efficacy and superinfection rates in complicated urinary tract infections treated with ertapenem or piperacillin tazobactam Bacterial penetration of bladder epithelium through lipid rafts D-mannose transport and metabolism in isolated enterocytes Prevalence of antibiotic resistance in US hospitals Regulation of acid resistance by connectors of two-component signal transduction systems in Escherichia coli Virulence and immunomodulatory roles of bacterial outer membrane vesicles In vitro antibacterial activity of Parkia biglobosa (Jacq.) root bark extract against some microorganisms associated with urinary tract infections Google Scholar Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli alata reduces bacterial load by inducing uroepithelial cell apoptosis Ratio of “A-type” to “B-type” proanthocyanidin interflavan bonds affects extra-intestinal pathogenic Escherichia coli invasion of gut epithelial cells Comparison of isolated cranberry (Vaccinium macrocarpon Ait.) proanthocyanidins to catechin and procyanidins A2 and B2 for use as standards in the 4-(Dimethylamino)cinnamaldehyde assay Urology and nephrology update: recurrent urinary tract infection PubMed Abstract | Google Scholar Flores-Mireles mechanisms of infection and treatment options Adhesive fiber stratification in uropathogenic Escherichia coli biofilms unveils oxygen-mediated control of type 1 pili A-type proanthocyanidin trimers from cranberry that inhibit adherence of uropathogenic P-fimbriated Escherichia coli Urinary tract infection syndromes occurrence Epidemiology of urinary tract infections - transmission and risk factors PubMed Abstract | CrossRef Full Text The honeybee syndrome - implications of the teratogenicity of mannose in rat-embryo culture Assessment of fosfomycin for complicated or multidrug-resistant urinary tract infections: patient characteristics and outcomes The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells Intracellular bacterial biofilm-like pods in urinary tract infections CrossRef Full Text Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D-3 Carbohydrate-deficient glycoprotein syndromes Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG Pilicide ec240 disrupts virulence circuits in uropathogenic Escherichia coli PubMed Abstract | CrossRef Full Text Antibiotic resistance properties of uropathogenic Escherichia coli isolated from pregnant women with history of recurrent urinary tract infections CrossRef Full Text | Google Scholar The urinary bladder transcriptome and proteome defined by transcriptomics and antibody-based profiling The association between serum 25-hydroxy vitamin D level and urine cathelicidin in children with a urinary tract infection PubMed Abstract | CrossRef Full Text Exploring the 3D molecular architecture of Escherichia coli type 1 pili Lead optimization studies on fimH antagonists: discovery of potent and orally bioavailable ortho-substituted biphenyl mannosides Structure-based drug design and optimization of mannoside bacterial fimH antagonists Host-pathogen checkpoints and population bottlenecks in persistent and intracellular uropathogenic Escherichia coli bladder infection Surfactant protein A inhibits growth and adherence of uropathogenic Escherichia coli to protect the bladder from infection Vitamin D induction of the human antimicrobial peptide cathelicidin in the urinary bladder Therapy of urinary tract infections with Candida PubMed Abstract | CrossRef Full Text Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study A-type cranberry proanthocyanidins and uropathogenic bacterial anti-adhesion activity Efficacy of ceftolozane/tazobactam versus levofloxacin in the treatment of complicated urinary tract infections (cUTIs) caused by levofloxacin-resistant pathogens: results from the ASPECT-cUTI trial and preliminary clinical efficacy of a vaccine against extraintestinal pathogenic Escherichia coli in women with a history of recurrent urinary tract infection: a randomised High trimethoprim-sulfamethoxazole resistance in ciprofloxacin-resistant Escherichia coli strains isolated from urinary tract infection Google Scholar Lutelin prevents fMLP-induced neutrophils adhesion via suppression of LFA-1 and phosphodiesterase 4 activity CrossRef Full Text Critical review of current definitions of urinary tract infections and proposal of an EAU/ESIU classification system The IrgA homologue adhesin Iha is an Escherichia coli virulence factor in murine urinary tract infection Filamentation by Escherichia coli subverts innate defenses during urinary tract infection Uropathogenic Escherichia coli modulates immune responses and its curli fimbriae interact with the antimicrobial peptide LL-37 Substances released from probiotic Lactobacillus rhamnosus GR-1 potentiate NF-kappa B activity in Escherichia coli-stimulated urinary bladder cells Katnik-Prastowska Bacterial adhesins in host-microbe interactions Randomised trial of cranberry-lingonberry juice and Lactobacillus GG drink for the prevention of urinary tract infections in women Molecular blueprint of uropathogenic Escherichia coli virulence provides clues toward the development of anti-virulence therapeutics The roles of the host and the pathogens in urinary tract infections CrossRef Full Text D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial PubMed Abstract | CrossRef Full Text Effects of flavonoids on cyclic-AMP phosphodiesterase and lipid mobilization in rat adipocytes Toll-like receptors in urothelial cells-targets for cancer immunotherapy Leatham-Jensen Uropathogenic Escherichia coli metabolite-dependent quiescence and persistence may explain antibiotic tolerance during urinary tract infection Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264.7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway Antibacterial and anti-inflammatory effects of extracts and fractions from Polygonum capitatum Cranberries and urinary tract infections: how can the same evidence lead to conflicting advice ‘Omic’ approaches to study uropathogenic Escherichia coli virulence Novel strategies in the prevention and treatment of urinary tract infections Estrogen supports urothelial defense mechanisms Lüthje Lactuca indica extract interferes with uroepithelial infection by Escherichia coli Lüthje Gynostemma pentaphyllum exhibits anti-inflammatory properties and modulates antimicrobial peptide expression in the urinary bladder Urinary tract infections in women: pathogenesis CrossRef Full Text | Google Scholar The co-transcriptome of uropathogenic Escherichia coli-infected mouse macrophages reveals new insights into host-pathogen interactions Urinary tract infection: pathogenesis and outlook EFFECT of phytocremical concentrations on biological activities of cranberry extracts A TRP channel senses lysosome neutralization by pathogens to trigger their expulsion Cranberry and recurrent cystitis: more than marketing Siderophore vaccine conjugates protect against uropathogenic Escherichia coli urinary tract infection Urinary tract infections in the menopausal period: optimal management Urinary tract infections in older women a clinical review A novel protective vaccine antigen from the core Escherichia coli genome Moya-Dionisio Uropathogen pattern and antimicrobial susceptibility in positive urinary cultures isolates from paediatric patients PubMed Abstract Dysregulation of Escherichia coli alpha-hemolysin expression alters the course of acute and persistent urinary tract infection Establishment of a multi-species biofilm model and metatranscriptomic analysis of biofilm and planktonic cell communities Uropathogen resistance to antibiotic prophylaxis in urinary tract infections Neutrophils and immunity: challenges and opportunities a novel broadly conserved Escherichia coli adhesin eliciting protection against urinary tract infections Oral vaccine (OM-89) in the recurrent urinary tract infection prophylaxis: a realistic systematic review with meta-analysis Cranberry for prevention of urinary tract infection Antibacterial effects of Alchornea cordifolia (Schumach Arg extracts and compounds on gastrointestinal The association between serum levels of vitamin D and recurrent urinary tract infections in premenopausal women Recurrence and follow-up after urinary tract infection under the age of 1 year O'Brien Drug and vaccine development for the treatment and prevention of urinary tract infections PubMed Abstract | CrossRef Full Text Prevention of urinary tract infection with oximacro (R) a cranberry extract with a high content of a-type proanthocyanidins: a pre-clinical double-blind controlled study Google Scholar Inhibition of biofilm development of uropathogens by curcumin - An anti-quorum sensing agent from Curcuma longa Tamm-Horsfall protein binds to type 1 fimbriated Escherichia coli and prevents E coli from binding to uroplakin Ia and Ib receptors Randomized comparative study for the assessment of a new therapeutic schedule of fosfomycin trometamol in postmenopausal women with uncomplicated lower urinary tract infection Long-term care acquired urinary tract infections' antibiotic resistance patterns and empiric therapy: a pilot study The pharmacological activities of compound Salvia plebeia granules on treating urinary tract infection Antibacterial activity of essential oils on microorganisms isolated from urinary tract infection Oestrogens for preventing recurrent urinary tract infection in postmenopausal women CrossRef Full Text | Google Scholar Evaluation of the antibacterial potential of Petroselinum crispum and Rosmarinus officinalis against bacteria that cause urinary tract infections Global dissemination of a multidrug resistant Escherichia coli clone Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria Extraintestinal pathogenic Escherichia coli a common human pathogen: challenges for vaccine development and progress in the field Genetic analysis of Escherichia coli biofilm formation: roles of flagella Inflammasomes in the urinary tract: a disease-based review Antiadhesion as a functional concept for protection against uropathogenic Escherichia coli: in vitro studies with traditionally used plants with antiadhesive activity against uropathognic Escherichia coli Traditionally used medicinal plants against uncomplicated urinary tract infections: are unusual flavan-4-ol- and derhamnosylmaysin derivatives responsible for the antiadhesive activity of extracts obtained from stigmata of Zea mays L coli and Benzethonium chloride as frequent contaminant faking potential antibacterial activities Antimicrobial activity of ulopterol isolated from Toddalia asiatica (L.) Lam.: a traditional medicinal plant In vitro testing of Lactobacillus acidophilus NCFM (TM) as a possible probiotic for the urogenital tract CrossRef Full Text | Google Scholar Functional genomic studies of uropathogenic Escherichia coli and host urothelial cells when intracellular bacterial communities are assembled Green tea as an effective antimicrobial for urinary tract infections caused by Escherichia coli Intravesical administration of green tea extract attenuates the inflammatory response of bacterial cystitis - a rat model Docking studies of flavonoid compounds as inhibitors of beta-ketoacyl acyl carrier protein synthase I (Kas I) of Escherichia coli Antibacterial activity of some plant extracts against extended-spectrum beta-lactamase producing Escherichia coli isolates Antimicrobial resistance in uropathogen isolates from patients with urinary tract infections Agrobacterium rhizogenes-mediated transformation of a multi-medicinal herb Boerhaavia diffusa L.: optimization of the process and anti-microbial activity against bacterial pathogens causing urinary tract infections Catch-bond mechanism of the bacterial adhesin FimH Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium Schneeberger Interventions for preventing recurrent urinary tract infection during pregnancy Regulation of fim genes in uropathogenic Escherichia coli Probiotics for preventing urinary tract infections in adults and children CrossRef Full Text | Google Scholar Antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections Cyperus rotundus: a potential novel source of therapeutic compound against urinary tract pathogens CrossRef Full Text | Google Scholar Mannose metabolism: more than meets the eye Mannose supplements induce embryonic lethality and blindness in phosphomannose isomerase hypomorphic mice invasion and cytotoxicity of UPEC in bladder epithelial cells and inhibits UPEC biofilm formation Dietary flavonoid luteolin attenuates uropathogenic Escherichia coli invasion of the urinary bladder Antimicrobial activity of lactobacillus strains against uropathogens From physiology to pharmacy: developments in the pathogenesis and treatment of recurrent urinary tract infections Lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane Effect of oral cranberry extract (standardized proanthocyanidin-A) in patients with recurrent UTI by pathogenic E-coli: a randomized placebo-controlled clinical research study In vitro antimicrobial activity of schefflera leucantha: the potential of respiratory tract and urinary tract infection treatment The battle for iron between bacterial pathogens and their vertebrate hosts Improved classification of urinary tract infection: future considerations CrossRef Full Text | Google Scholar TLR4-Initiated and cAMP-Mediated abrogation of bacterial invasion of the bladder Adhesive pili in UTI pathogenesis and drug development The innate immune response during urinary tract infection and pyelonephritis Evolutionary history of the global emergence of the Escherichia coli epidemic clone ST131 Subashchandrabose Host-specific induction of Escherichia coli fitness genes during human urinary tract infection Urine human beta defensin-1: a natural bladder cancer inhibitor CrossRef Full Text | Google Scholar Design and evaluation of pilicides: Potential novel antibacterial agents directed against uropathogenic Escherichia coli doi: 10.1002/1439-7633(20011203)2:12<915::AID-CBIC915>3.0.CO;2-M Inhibition of herpes simplex type 1 and type 2 infections by Oximacro (R) a cranberry extract with a high content of A-type proanthocyanidins (PACs-A) Treatment of refractory interstitial cystitis/painful bladder syndrome with CystoProtek - an oral multi-agent natural supplement Modulatory antimicrobial activity of Piper arboreum extracts Uropathogenic Escherichia coli infection: potential importance of epigenetics The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract Efficacy of an orally administered combination of hyaluronic acid curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women Which antibiotoc is better to select empirically for lower urinary tract infections in pregnant women Google Scholar In vitro antioxidant and antimicrobial activities of Costus spicatus swartz used in folk medicine for urinary tract infection in Brazil Google Scholar Antimicrobial activity of Vernonia amygdalina on selected urinary tract pathogens CrossRef Full Text | Google Scholar Changes in the inflammatory markers with advancing stages of diabetic nephropathy and the role of pentraxin-3 Effects of Extracts from Medicinal Plants on Biofilm Formation by Escherichia coli urinary tract isolates Adjuvant effect of cranberry proanthocyanidin active fraction on antivirulent property of ciprofloxacin against Pseudomonas aeruginosa Management of uncomplicated recurrent urinary tract infections In vitro antibacterial activity of aqueous and ethanol extracts of Aristolochia indica and Toddalia asiatica against multidrug-resistant bacteria What determines differentiation of urothelial umbrella cells Presence of putative repeat-in-toxin gene tosA in Escherichia coli predicts successful colonization of the urinary tract Vollmerhausen Decoctions from Citrus reticulata Blanco seeds protect the uroepithelium against Escherichia coli invasion Effect of different cranberry extracts and juices during cranberry juice processing on the antiproliferative activity against two colon cancer cell lines In vitro activity of heather Calluna vulgaris (L.) HULL extracts on selected urinary tract pathogens Urinary clearance of cranberry flavonol glycosides in humans Sequential and compartmentalized action of Rabs and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells The pilus usher controls protein interactions via domain masking and is functional as an oligomer The effects of triclosan on uropathogen susceptibility to clinically relevant antibiotics Origins and virulence mechanisms of uropathogenic Escherichia coli Medicinal plants extracts affect virulence factors expression and biofilm formation by the uropathogenic Escherichia coli Uropathogenic Escherichia coli flagella aid in efficient urinary tract colonization The multiple antibacterial activities of the bladder epithelium Comparative analysis of the uropathogenic Escherichia coli surface proteome by tandem mass-spectrometry of artificially induced outer membrane vesicles Comparative proteomics of uropathogenic Escherichia coli during growth in human urine identify UCA-like (UCL) fimbriae as an adherence factor involved in biofilm formation and binding to uroepithelial cells Zacché Therapies in early development for the treatment of urinary tract inflammation On the essentiality of lipopolysaccharide to Gram-negative bacteria Gribaudo G and Maffei ME (2017) UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors and Non-antibiotic Antimicrobial Strategies Received: 15 May 2017; Accepted: 02 August 2017; Published: 15 August 2017 Copyright © 2017 Terlizzi, Gribaudo and Maffei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) or licensor are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Massimo E. Maffei, bWFzc2ltby5tYWZmZWlAdW5pdG8uaXQ= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Several women say they made statements about Hubert Greliak but they were mishandled by police The Metropolitan police may have missed a chance to bring charges over a series of alleged assaults by the same man, several women have told the Guardian. The women made statements to the Met and allege the force mishandled their claims about Hubert Greliak, who they claim may be a serial attacker. Greliak was convicted in January of rape against one woman. On Tuesday he was sentenced to 13 years and six months in jail and an extended period on licence of four years and six months for that attack. The woman in that case, Juliana Terlizzi, 34, has waived her right to legal anonymity. She tracked down other women through social media who made claims against Greliak stretching over 11 years. After Greliak was arrested in March 2020 for the attack on Terlizzi, at least two more women came forward and made statements to the police. One said she had been put off after her contact with the Met. Another said police just seemed to give up on her case, with one officer making a remark she found offensive. They say Greliak could receive a shorter jail sentence than had the claims been investigated properly and potential other charges been put before the court. They fear Greliak may remain a danger to women after his release from prison. The Met said it handled the case properly and urged women to come forward. The force said it was “absolutely dedicated to achieving criminal justice outcomes for victim-survivors”. Police said they received one other complaint against Greliak, which was investigated and did not lead to charges. A solicitor for Greliak said he could not comment because his client was in jail so could not be reached. The Met has been under fire for how it handles crimes against women, especially rape. A report last year by the victims’ commissioner for London, Claire Waxman, found nearly two-thirds of rape victims in London, which is covered by the Met, who dropped their complaints did so within a month of going to police, with the proportion tripling in two years. At the time Terlizzi was attacked in February 2020 she was in a relationship with Greliak. She said he drugged her, and he was convicted at Isleworth crown court for then raping her and filming the attack. He was also convicted for assault by penetration, theft and refusing to give the passcode to his phone. During the attack, with Terlizzi unconscious, he said: “I’m completely raping you … ” As her case progressed Terlizzi became convinced her attacker was breaching his bail conditions but said police did not take her seriously: “They said I was overreacting, overthinking things. They said I should go to the doctor and get medication.” It turned out Terlizzi was right and Greliak ended up having his bail revoked for breaching it. She said she was asked to give detectives access to her phones, computers and social media: “The police treated me as a suspect and made it almost unbearable for me to support the case moving forward. It was almost as if they wanted me to give up and drop the case, which had a huge impact on my mental health.” Terlizzi spoke to Greliak’s past girlfriends and partners and found 10 others who she said complained about his behaviour, with allegations ranging from rape and assault to controlling and abusive behaviour. One woman who alleges she was raped during a five-year relationship with Greliak says police mishandled her case. Kate (not her real name) came forward to support Terlizzi’s case and said she still had nightmares and had not told her family what happened. Kate said: “I thought that he had only got worse while he was with me and that maybe even part of it was actually my fault, that I had enabled him and allowed him to get worse. I considered it important to report my experience too, and finally cut ties with him once and for all.” She added that she did not believe “a person like this” would “stop abusing women of his own accord”. She said: “I found it extremely hard to get myself around to report my experience, as I have no proof of what he did to me over the five years we were together. I didn’t know what domestic rape was, and had serious doubts about what constitutes emotional and even physical abuse … ” She said she filed an online report to police and was shocked and embarrassed when police turned up at the temporary accommodation where she was staying. “Overall, I felt the police handling of the case was tactless, I especially feel they didn’t realise the shame it would bring me the fact that they showed up at my Airbnb and that therefore I didn’t have any privacy to talk about my report.” Rose (not her real name) alleged she was sexually assaulted in a London bar and made a statement to police. Her identity was relayed to Greliak by police in interview – normal police procedure so he could respond – and he denied everything. Rose said she was hurt when one officer said: “At least he knows how you feel.” Rose said: “My only intention was to report the truth of what had happened in order to protect others.” She said Greliak had once said to her: “You look so hot I could rape you.” Terlizzi said she feared he would spend only a few years in jail and emerge as a continued threat to women. “As it stands, Greliak was only prosecuted and convicted for the crimes he committed in relation to me. I have no doubt Greliak will reoffend and I worry for my safety and that of other women when he is released from jail.” She told the court during her victim impact statement as Greliak was sentenced: “If he is capable of committing such horrifying crimes to someone he allegedly loves, I am terrified to imagine what he is capable of doing to someone he doesn’t. His behaviour and actions are those of a psychopath.” The Met initially said no other women had made allegations of criminal offences against Greliak. It later revised its statement and said: “As part of the wider investigation officers approached a number of individuals in relation to Greliak’s behaviour. On 23 May 2020, the [Met] received one allegation of sexual assault that was alleged to have taken place in 2012. The allegation was investigated and the case discontinued with no further action. “We can assure survivors that any allegation will be taken seriously and you will be fully supported. We are committed to tackling all forms of violence against women and girls and are absolutely dedicated to achieving criminal justice outcomes for victim-survivors.” We don’t flood you with panic-inducing headlines or race to be first We focus on being useful to you — breaking down the news in ways that inform We rely on readers like you to fund our journalism Will you support our work and become a Vox Member today The maternal mortality rate in the state is a third of the American average by Julia Belluz LinkKristen Terlizzi was diagnosed with placenta accreta, a condition that can cause the placenta to grow out of control like a cancer. One in fourteen women with accreta die. | Courtesy of Kristen TerlizziKristen Terlizzi woke up on July 16 in the intensive care unit at Stanford University to the news that the placenta connecting her to the child she’d just given birth to had spread like a cancer through her abdomen a condition that can cause the placenta to grow out of control and then is flushed out of the body after the birth In accreta, which doctors believe is most often caused by scarring from prior cesarean sections, the placenta sticks around and embeds. The condition was exceedingly rare in the 1950s, occurring in only one in 30,000 deliveries in the US. Today, because of the rise in C-sections, it shows up in about one in 500 births Childbirth is one of the most common reasons women go into hospitals, and yet the American health care system handles complicated pregnancies with a stunning lack of preparation and precision. Put simply, women who give birth in the US have a greater risk of dying relative to other rich countries — and the problem has been growing worse at a time when America’s peers have continued to make pregnancy safer But the fact that she lives in California — a state that a decade ago decided to take the American tragedy of maternal death seriously — may well have saved her life Terlizzi’s only risk factor for accreta was a prior C-section with her first son Her doctors had planned to surgically remove the placenta after Leo was born But when the surgeons opened up her abdomen they discovered the placenta had filled her entire pelvis “They couldn’t see anything not affected,” she said Several weeks later, still in the hospital, Terlizzi developed a deadly blood clotting condition caused by the leftover tissue Doctors attempted to remove the rogue placenta again Terlizzi began to hemorrhage as surgeons raced to cut out the placental tissue A mother can bleed to death in childbirth within five minutes as obstetric anesthesiologists carefully measured how much blood she was losing and gave her 26 units of blood products — effectively replacing all of the blood in her body Terlizzi lives with her husband and two children in Silicon Valley The only remnant from the surgeries is a wide Her pregnancy was so exceptionally complicated, it inspired a scientific journal case study But it’s also emblematic of how unpredictably dangerous birth can be even for healthy women — and how the deadliest pregnancy complications are survivable when hospitals prepare for them The Stanford doctors and nurses who treated her were ready with a precise set of steps to manage her care. Among them: hemorrhage guidelines created by a doctor named David Lagrew as part of Stanford’s California Maternal Quality Care Collaborative (CMQCC) a revolutionary initiative to make births safer for moms in the state they’ve proved that even within America’s imperfect health system death in childbirth is not an inevitability In the US, childbirth has been growing more dangerous recently. Maternal mortality — defined as the death of a mother from pregnancy-related complications while she’s carrying or within 42 days after birth — in the US soared by 27 percent, from 19 per 100,000 to 24 per 100,000, between 2000 and 2014 That’s more than three times the rate of the United Kingdom, and about eight times the rates of Netherlands, Norway, and Sweden, according to the OECD It’s a stunning example of how poorly the American health care system stacks up against its developed peers. More women in labor or brand new mothers die here than in any other high-income country. And the CDC Foundation estimates that 60 percent of these deaths are preventable But as the mortality rate has been edging up nationally California has made remarkable progress in the opposite direction: Fewer and fewer women are dying in childbirth in the state So how did California manage to buck the trend? I was curious, particularly as American women’s health is under assault with the GOP push to repeal and replace the Affordable Care Act I went to California to learn about what they were doing right, and found that all roads led to CMQCC the multi-disciplinary health collective (based out of Stanford) On my first day in Orange County, I met with Dr. David Lagrew, an OB-GYN and founding member of the CMQCC He’s been instrumental in helping drive down California’s maternal mortality rate including creating the hemorrhage protocols that may have saved Terlizzi’s life Lagrew moved to Southern California for a medical fellowship in 1984 he saw a placenta accreta case at Long Beach Memorial that has haunted him since “It was just blood everywhere,” he says in a slow Kentucky drawl that’s softened after more than two decades in California where he is now the medical director for women’s health for St overseeing five hospitals in the region that do obstetrical work This includes facilities in richer parts of the state an isolated town on the edge of the Mojave Desert “The lady ended up getting over 50 units of blood,” he recalls The hospital didn’t know how to the handle the bleeding and Lagrew watched the mother go limp and die on the operating room table Around that time, an influential paper was published in the journal Obstetrics and Gynecology establishing the connection between the exponential rise in C-section rates and placenta accreta cases Lagrew started wondering about the suffering and death he had seen in the OR that day given that so many C-sections aren’t medically necessary (Doctors sometimes perform them to wrap up cases faster — and get reimbursed — before the end of their shift Patients also request them for reasons that have nothing to do with health.) who has neatly cropped salt-and-pepper hair and wire-rimmed glasses a self-professed “data geek.” He spent part of his undergraduate degree teaching himself computer programming and coded for the Forestry Department at the University of Kentucky to pay his way through school He thought that if he could gather data on doctors’ C-section rates and educate his fellow clinicians about how many they were doing and the risks of unnecessary surgeries he might be able to reduce C-sections that aren’t medically indicated — and complications like placenta accreta when Lagrew was appointed medical director at Saddleback Hospital in Laguna Hills When he’d hand doctors data on their C-section rates “What the heck is this?” Some would even scream at him “I didn’t do this one C-section and you put it on my report!” they’d say Lagrew would respond: “What about the other 215?” The C-section rate at Saddleback was halved within five years Lagrew has now managed similar feats at the eight hospitals where he’s worked since and at hundreds more in the state through CMQCC His method is a microcosm for how CMQCC works: Collect data about maternal health zero in on the complications that can be prevented figure out what the evidence says about the steps required to prevent them and then engage stakeholders and mentor them as they follow those lifesaving steps Hemorrhage and preeclampsia (pregnancy-induced severe high blood pressure) are the two most common — and preventable — causes of death which runs as a collective and is mainly funded by the California Healthcare Foundation and the Centers for Disease Control and Prevention was imagined in a Los Angeles airport hotel meeting room in 2006 a time when the state’s maternal mortality rates had recently doubled A group of concerned doctors, nurses, midwives, and hospital administrators, including CMQCC medical director Elliott Main started a maternal mortality review board to pore over each death in detail and identify its root causes hemorrhage and preeclampsia (pregnancy-induced severe high blood pressure) floated to the top of the list as the two most common — and preventable — causes of death One of the United Nations’ Millennium Development Goals focused on driving down the maternal mortality rate. This led to efforts in almost every country to save moms’ lives — and they were largely successful: The global maternal mortality rate dropped by 44 percent worldwide between 1990 and 2015 that saw its maternal death rate increase since 1990 “We are going in opposite direction of the whole worldwide trend,” says University of Maryland researcher Marian MacDorman, who co-authored the best available national study of US maternal mortality in 2016 “It’s a travesty,” says MacDorman “Mongolia has a maternal mortality rate and the US with all our wealth and health care can’t publish a maternal mortality rate.” Part of America’s increase has to do with changes in how maternal deaths are codified on death certificates health officials realized that maternal deaths were being underreported But that’s far from the only explanation according to MacDorman and other researchers who study maternal health there’s been a decline in access to contraception and abortion in many parts of the US The opioid epidemic certainly hasn’t made births safer for moms and health care access remains poor for low-income and minority women who have among the worst maternal health outcomes which can sometimes save moms’ and babies’ lives has also contributed to more pregnancy complications in subsequent births American women are also heavier on average, and having babies later in life putting them at a higher risk of complications in the maternity ward Yet other developed countries have seen similar health trends in rising childbirth age and bodyweight — without the accompanying increased death risk for mothers That’s led researchers like Boston University maternal health expert Eugene Declercq to conclude that a key driver of America’s maternal mortality problem is that America doesn’t value women “The argument we make internationally is that [a high maternal death rate] is often a reflection of how the society views women,” he says we worry about the culture — women are not particularly valued so they don’t set up systems to care for them at all I think we have a similar problem in the US.” there are advocates at the state level who are working on the problem As of 2013, there were 7.3 deaths per 100,000 in California — bringing the Golden State in line with countries like the United Kingdom or Portugal That’s also half of what the state’s maternal death rate was in 2006 Considering that more than half a million women give birth in California each year the progress in curbing maternal mortality has been profound To start to tackle the problem, CMQCC created “toolkits,” which are essentially evidence-based step-by-step recipes — downloadable for free — on how teams of health care providers in hospitals can best prepare for and manage the sometimes deadly complications that arise with childbirth focused on maternal hemorrhage — what their maternal death review revealed was one of the most common and preventable causes of death in California Only about 2 percent of a woman’s total blood volume flows through her uterus that number rises to 10 percent to nourish the placenta and the baby The most common cause of postpartum hemorrhage is a uterine atony — when the uterus does not contract and stop bleeding after the placenta breaks off About 30 percent of women who experience an obstetric hemorrhage don’t have an identifiable risk factor so it’s hard to know who might be at risk One key idea in the hemorrhage toolkit was to make sure hospitals were armed with all the best protocols and necessary tools that might save those moms’ lives in the event of a bleed waist-high rolling cart with four drawers and red handles known as “the hemorrhage cart.” Every hospital delivering babies should have one The cart is filled with everything to manage a hemorrhage: medicines that slow the flow of blood instruments that repair a tear or laceration intrauterine balloons that can provide pressure and control bleeding from a uterus that isn’t contracting well Where do I find a balloon catheter to stop the bleed?’” Lagrew says When CMQCC did their root cause analysis on what was causing moms to die in their state they found that hospitals typically didn’t have these simple things on hand So they borrowed the idea from the “code blue cart” that’s common in hospitals to quickly treat patients who go into cardiac arrest “No one had ever made the code blue for obstetrical hemorrhage,” Lagrew added You need to measure blood better.’” Learning about CMQCC’s approach opened my eyes to all the places where maternal health care — managing one of the most universal experiences women go through — isn’t very precise or evidence-based Doctors and nurses typically eyeball blood loss — and these estimations are notoriously inaccurate Another piece of guidance in the CMQCC hemorrhage toolkit is that doctors and nurses need to have blood products ready for moms who bleed in childbirth and they should carefully measure blood loss during the pregnancy to make sure the patient’s levels are being adequately replenished To do this, CMQCC recommends a practice called “quantitative blood loss,” Lagrew explained Doctors and nurses typically eyeball blood loss — and these estimations are notoriously inaccurate CMQCC suggests weighing dry sponges and pads that collect blood on the operating table before a surgery and then doing so again after they’ve been soaked to calculate how much blood a mother lost Lagrew is now trying to make the process even better at his hospitals where Brahms’ Lullaby chimes whenever a baby is born alongside the ever-present hum of fetal heart monitors I watched a training session for nurses on how to use a machine that automates quantitative blood loss The founder of the Silicon Valley company Gauss Surgical, Siddarth Satish, noticed that every vital sign in the operating room was carefully monitored and measured, except for blood loss. So he created Triton OR an FDA-approved blood loss monitor with an iPad interface that allows health care providers to quickly weigh their tools before they’re filled with blood and afterward Lagrew introduced the machine at the hospital as part of a pilot — one of many things he’s constantly experimenting with to make childbirth safer “It’s classic process improvement to the point where the doctors and nurses go but everything went pretty smoothly,” he said and didn’t go in the intensive care unit.’” I wanted to see how the CMQCC approach worked in a resource-strapped area of the state a hospital that delivers nearly half of the babies born in and around Apple Valley Apple Valley is a town filled with hills of dusty golden rocks and strip malls in a remote region of Southern California, sandwiched between Los Angeles and Las Vegas. Here, the median household income is $47,938 — about a third of Newport Beach’s Almost all the pregnancies nurses and doctors see here are complicated by diabetes or other issues that put moms and babies at a higher risk of death Mary’s hasn’t seen a maternal death in at least 23 years Sitting in front of a stack of charts, Mendy Hickey, a nurse, beamed about gains on maternal health measures. St. Mary’s had just won a CMQCC award for their low C-section rate — among the lowest in the state, at 21 percent. They’d massively driven down their rate of early elective deliveries, or births that happen before 39 weeks gestation, by following CMQCC’s approach Babies who are born prematurely have a higher chance of winding up in the neonatal intensive care unit and needing respiratory support early deliveries mean more inductions and C-sections — and more potential complications Hickey and her colleagues started talking about early elective deliveries at every department meeting They posted data about doctors’ individual rates in the units and doctor lounges “That always works really well,” she said When they spotted an early delivery that wasn’t medically necessary the department chief would have a conversation with the physician about her decision and suggest the doctor avoid doing so again Mary’s to access a data center where they could compare their progress on maternal health against other hospitals and doctors in the state “The database alone has been huge,” Hickey says Mary’s started to focus on early elective deliveries in late 2014 when they were 9 percent of all births at the hospital 2 percent of babies were being delivered early when it wasn’t medically indicated “Data speaks — big time.” Every doctor and nurse I spoke to that day was plugged into these quality improvement efforts They bragged about their award-winning low C-section rates and reducing hemorrhage risk like they were talking about their children’s report cards I could also see how it affected patients’ lives particularly in the neediest and most complicated cases she’d worked as a package handler and sorter at an Amazon warehouse in nearby San Bernardino which heightened her risk of pregnancy-induced high blood pressure (or preeclampsia) her doctor discovered her blood pressure had shot up to a dangerously high 253/186 and that she wasn’t responding to hypertension medication High blood pressure can cut off the amount of blood and nutrients that reach the fetus Brooks was quickly shuffled off for an emergency C-section that saved her life “I would have had a stroke if I didn’t deliver,” she says while rocking Onyx in the neonatal intensive care unit a beige room humming with the buzz of vital sign monitors and incubators CMQCC’s toolkits have been downloaded more than 24,000 times and more than 200 of California’s 243 maternity hospitals have joined the organization to work on improving maternal health In one recent study researchers found a 21 percent reduction in severe health problems associated with hemorrhages in the California hospitals participating in CMQCC’s programs Hospitals that didn’t join the effort saw a non-significant 1 percent reduction California has also seen its maternal mortality rate decline by 55 percent at a time when other states are documenting increases as well as insurance payers have recognized that making births safer saves them money They’ve supported CMQCC by helping pressure hospitals to follow the steps to protect women in the workforce — and avoid incurring unnecessary costs that drive up insurance premiums It’ll make maternity benefits optional for private health plans and defund Planned Parenthood — where 2.5 million Americans access family planning and maternity care services The Better Care Act would also gut Medicaid, which covers about half of all births in the US. If the GOP plan passes, the nonpartisan Congressional Budget Office expects it will result in more unplanned pregnancies and 22 million people losing their health care within a decade The state boasts the largest uninsured population in America But long before the GOP plan or the current health reform debate the US lagged behind other rich countries when it comes to providing women access to the comprehensive health care necessary for safe pregnancies and deliveries “There are a lot of areas where America’s policies are less protective [for mothers] than they are in Canada and other developed countries,” said Adam Sonfield senior policy manager at the Guttmacher Institute “Being able to take time off from work to go to the doctor and having child care to make sure you can go to that doctor and making sure you have affordable transportation to go to that doctor” — it’s uniformly more difficult for American moms we haven’t bothered to create national health policies around maternity care that are focused on improving outcomes for mothers such as a federal maternity leave policy or universal health care Maternal health is also becoming more complicated. The clinical complications CMQCC has focused on so far — hemorrhage, preeclampsia — are being outpaced by lifestyle-related health issues like cardiovascular disease and opioid addiction There are also astounding racial disparities in maternal health: Black mothers are three times more likely to die in childbirth than white women It’ll require more than well-meaning doctors and nurses to fix these problems Still, California has demonstrated that even in our messy and imperfect health care system, progress is possible. They’ve shown the rest of the country what happens when people care about and organize around women’s health. Policymakers owe it to the 4 million babies born in the US each year to figure out how to bring that success to families across the country The difference between Texas and California is that California decided to take on maternal mortality Kristen Terlizzi, the accreta patient who started the National Accreta Foundation to raise awareness about it has been thinking about the potential health reforms coming down “I’ve come to appreciate the concerns about lifetime limits Thank God my surgery happened before this was an issue,” she said of the GOP push to reintroduce caps on how much health care costs patients can get coverage for over a lifetime “I had this perception that maternal mortality was a faraway issue or an issue of the past I had no idea healthy mothers in this country were experiencing things like this.” For more on this story, listen to our maternal health episode of Vox’s The Impact podcast Editor: Eliza Barclay Photographer: Julia BelluzPhoto editor: Kainaz AmariaCopy editor: Bridgett HenwoodProject manager: Susannah LockeGraphics: Javier Zarracina and Sarah Frostenson Understand the world with a daily explainer plus the most compelling stories of the day UnexplainableApr 23The real quest for fake bloodLab-grown blood could save tens of thousands of lives. Is it possible? The one allergy treatment to rule them all, explained. Trump’s crackdown on foreign students and scientists will do irreparable harm to the country. Editor's note: This is an updated version of the original story The State Highway Patrol clarified Friday afternoon that despite the information in the charging document A Linden man is charged with impaired driving and felony death by vehicle in the hit-and-run death of a Cumberland County deputy early Friday according to the Cumberland County Sheriff's Office is charged with felony death by vehicle and hit-and-run resulting in death; and misdemeanor driving while impaired driving without insurance and driving without registration according to the North Carolina State Highway Patrol charging document He was also cited with a red light infraction Terlizzi is being held in the Cumberland County jail without bail Cumberland County District Attorney Billy West said The charging document stated both Bolanos-Anavisca Jr but the SHP clarified Friday afternoon that the dog was not injured Terlizzi's occupation on the document is listed as a tow-truck driver What happened?The Sheriff's Office said that deputies were investigating a robbery at Circle K at 2990 Gillespie St was struck as he walked back to his patrol vehicle after a tracking K9 chased the scent of the robber identified by Sheriff Ennis Wright as a BMW was taken to Cape Fear Valley Medical Center nearly a dozen emergency vehicles still surrounded the scene as members of the North Carolina State Highway Patrol examined the debris-littered roadway A dark baseball cap could be seen lying among more than a dozen orange evidence cones in the Gillespie Street intersection The Sheriff's Office said Bolanos-Anavisca Jr selfless member of the Sheriff’s Office who lost his life protecting the citizens of Cumberland County." He began his career in the Sheriff's Office in November 2020 and previously served as a school resource officer at Hope Mills Middle School Cumberland County Schools issued a statement Friday afternoon noting Bolanos-Anavisca Jr.'s work at the school and that he was a 2018 graduate of South View High School in Hope Mills and a "great example of a successful student." "During his brief tenure (as an SRO) at Hope Mills Middle he made an indelible mark on the lives of the students he was a volunteer assistant football coach at Hope Mills Middle," the statement said "We will never forget his incredible service to our school system Our thoughts and prayers are with Deputy Oscar Yovani Bolanos-Anavisca’s family Hay Street United Methodist Church sent out a notice just before noon asking for prayers for the deputy's fiancee as law enforcement agencies across the state and others posted condolences to social media "To Sheriff Wright, fellow Deputies, and to the family of the fallen Deputy, our deepest condolences and heartfelt prayers are with you during this difficult time," reads a message on the Fayetteville Police Department's Facebook page The Spring Lake Police Department posted: "Terrible news this morning Cumberland County Sheriff’s Office in our hearts." In Hope Mills, where Bolanos-Anavisca, Jr. grew up, the Police Department posted on its Facebook page "Our thoughts and prayers are with Sheriff Wright Cumberland County Sheriff’s Office Deputies and with the family of the deputy killed in the line of duty." The Raleigh Police Department also offered condolences on Facebook Cumberland County Sheriff's Department Deputy Oscar Yovani Bolanos-Anavisca was tragically lost in the line of duty last night The Raleigh Police Department mourns and grieves with the family of our brother-in-blue we have the watch from here," the post read noting he'd been in contact with Sheriff Ennis Wright "We mourn Cumberland County Deputy Oscar Yovani Bolanos-Anavisca Jr who was killed in the line of duty," Cooper said in a statement on Twitter "I spoke with Sheriff Wright offering condolences support and appreciation for the men and women who keep our communities safe." and North Carolina flags at state facilities to be set at half-staff through sunset Saturday More than 20 members of the young deputy's family silently filed into the Sheriff's Office conference room on Friday afternoon for a news conference An older grief-stricken member was comforted by those around him as Sheriff Ennis Wright took to the podium "I'm standing here with a heavy heart," Wright said the weight of the loss apparent on his face stood out to him because he was so passionate about serving as a deputy "We had a young officer out here doing his job and his life was taken away so quickly behind a senseless act of someone getting behind the wheel after they been drinking," Wright said because deputies renewed their oaths this week "I take the responsibility for every deputy that's in this Sheriff's Office and this young man gave his life to this county for something that he wanted to do." Scott Smith with the SHP said evidence is being processed by the SBI and the investigation remained underway Some family members seated in the first two rows of the audience quietly wept into tissues as officials spoke Mitch Deaver with the SBI's Southeastern District Office in Fayetteville addressed the family directly We offer that to you as well as Sheriff Wright and the men and women of the Cumberland County Sheriff's Office," Deaver said "I can assure you that you are a part of their family and that they will be here for you and we will be here for you and we will hold each of you up in our thoughts and prayers." whose office is prosecuting the case against Terlizzi shared his condolences and emphasized the unnecessary nature of the crash "We did not have to be here this afternoon," he said "The one promise I can make to this family and to this community is we will get justice in this case for what was done today because we lost an officer that was serving and protecting us that was willing to give his life to serve and protect us." Wright closed the gathering by reassuring Bolanos-Anavisca Jr.'s family that they would not be alone "It's a calling to give your life for someone else and that's what this young man did," he said We're going to get through this together." According to the Officer Down Memorial Page website Bolanos-Anavisca Jr.'s death is the 13th line-of-duty death for the Sheriff's Office since 1916 The last Cumberland County deputy killed while on duty was Christopher Brian Matthews who died in an automobile crash on River Road on Sept More than a dozen uniformed Cumberland County deputies sat behind the grieving family of one of their own in a Cumberland County courtroom Wednesday as the man accused in his killing learned he may face a charge of second-degree murder 16 death of Deputy Oscar Yovani Bolanos-Anavisca Jr. while walking back to his patrol vehicle after participating in a search for a robbery suspect Terlizzi is also charged with misdemeanor driving while impaired Bolanos-Anavisca died from his injuries at Cape Fear Valley Medical Center marking the first time in 18 years — since the death of Deputy Christopher Matthews 28 — that a Cumberland County deputy died in the line of duty Matthews was killed in an automobile accident several members of the Cumberland County Sheriff's Office and its honor guard attended the Peace Officer Memorial Ceremony in Raleigh on May 2 and three deputies with the honor guard accompanied Bolanos-Anavisca's family to the National Peace Officer Memorial in Washington The bond hearingIn court Wednesday during a bond hearing requested by Terlizzi Senior Assistant District Attorney Rob Thompson said that his office would be presenting evidence on a second-degree murder charge in the case to the grand jury Cumberland County Sheriff Ennis Wright and four other deputies sat roughly 5 feet from Terlizzi in court Wednesday as Terlizzi’s attorney asked for his client’s $1 million bond to be reduced arguing it was excessive and unconstitutional Terlizzi has not been treated fairly,” Post said Clad in an orange jail jumpsuit and wearing glasses Terlizzi hunched over with sobs as his attorney spoke Post grew animated as he described the “political hot potato” of his client’s case and gestured to the gallery crowded with deputies and families from both sides indicating he believed Terlizzi was being treated unfairly because Bolanos-Anavisca was a deputy “That ain’t fair and that ain’t right,” Post said He said that video of the crash showed the light for Terlizzi was green when Bolanos-Anavisca was hit in the intersection but its contents were described to him by “a source,” he noted Thompson later clarified he was the source who told Post about the video which was in the hands of the State Highway Patrol It was not clear what the source of the video was Post argued the video would show that Terlizzi was traveling under the 55 mph speed limit at the time of the crash and was not swerving or driving recklessly “The deputy that was killed was standing in the middle of the road “It’s going to be extremely hard for the government to say that the proximate cause of the accident was Mr Thompson said Terlizzi reportedly had a blood alcohol content of .19 that morning more than twice the legal driving limit of .08 Post claimed that Terlizzi did not see Bolanos-Anavisca but realized he hit something and FaceTimed his girlfriend to ask if he should pull over She suggested he pull over at the Waffle House just down the road he was “surrounded” by deputies and arrested December arrest: 'Life was taken away so quickly': Arrest made in Cumberland County deputy's traffic death Post acknowledged that his client’s license was revoked at the time but said the revocation stemmed from a failure to appear in court for a minor traffic infraction Gesturing to the five members of Terlizzi’s family seated in the audience behind his client Post said Terlizzi had many people “in his corner” and requested his bail be reduced to $50,000 secured Terlizzi’s side is the Constitution,” Post said The defense attorney told Ammons he would be requesting the Cumberland County District Attorney’s Office recuse itself from Terlizzi’s case, pointing to a Dec. 16 Facebook post from District Attorney Billy West as proof that West’s office could not be impartial and prayers are with the family of Deputy Bolanos-Anavisca and the Cumberland County Sheriff’s Office as they cope with the tragic loss of one of our own while he was serving and protecting our community,” Post said in arguing that Terlizzi's bail remain at $1 million said Terlizzi must have realized he struck the deputy “The defendant had to be aware that he hit something,” he said noting Terlizzi’s car had “a great deal of damage” to its windshield and side mirror Thompson said his office believes Terlizzi may have been on FaceTime when he hit Bolanos-Anavisca and cited a magistrate’s finding that Terlizzi appeared unconcerned with the deputy’s death the day of the incident “The suspect showed very little remorse and stated multiple times the object broke his windshield,” Thompson said County's 13th loss: Deputy Bolanos-Anavisca was Cumberland County Sheriff's Office's 13th line-of-duty death Thompson said Terlizzi’s alleged decision to drink that night and use FaceTime while driving showed a lack of responsibility “Every human on the planet knows not to get behind the wheel when you’ve been drinking,” he said “That was the grand task of the defendant that night — getting hammered In ruling Terlizzi’s bail would remain at $1 million secured Ammons noted his reasons were that Terlizzi had failed to appear in court twice and failed to pay fines twice; his attorney's own admission that Terlizzi knew he hit something; and the revocation of Terlizzi’s license is not unreasonable given the totality of the circumstances,” Ammons said The judge added that he would consider any recusal requests from Post including any requests for Ammons to recuse himself “Any time a member of our community is killed whether it’s by accident or misadventure or ill intent it’s a loss to our community,” Ammons said Public safety reporter Lexi Solomon can be reached at ABSolomon@gannett.com We have the address for the funeral home & the family on file If you're not happy with your card we'll send a replacement or refund your money Betty Yates Crenshaw Towe, wife of the late James O. Towe and the late Campbell C. Crenshaw, passed away on December 13th, at Cottingham Hospice House in Seneca, SC. She was born in Shelbyville, Kentucky on October 23, 1925. She was the last... View Obituary & Service Information Betty Yates Crenshaw Towe created this Life Tributes page to make it easy to share your memories Trusted Health Information from the National Institutes of Health Anthony Terlizzi was just 16 months old when he had his first allergic reaction to peanuts She gave him a peanut butter and jelly sandwich and his whole face blew up," Lisa said She quickly took the sandwich away before Anthony had a chance to eat it Lisa had just watched a morning news show that warned of possible allergic reactions to bee stings The show recommended giving your child a small dose of antihistamine if you feared an allergic reaction Lisa called her son's pediatrician for guidance "His pediatrician told me to watch his breathing to get him to an emergency room," she said Anthony got better and they didn't need to visit the ER Lisa had her son tested by an allergist to confirm the peanut allergy She didn't know anyone with a peanut allergy "I try to live as normal a life as possible." "I started reading labels a little bit more Lisa's older daughter didn't have a peanut allergy Lisa found the best way to handle this was to carefully prepare food and make her son's food first to avoid cross-contamination Some children's allergies are more severe and may warrant extra precautions to avoid cross contamination with allergens She did this until Anthony was old enough to carry and use the EpiPen himself "It was about being vigilant and making sure we were prepared if anything happened," Lisa said She recognized that children should be aware of their allergies and know the dangers but "they can't be afraid to live either." who doesn't let his food allergy stop him from enjoying life "The same way that you wake up knowing you have to brush your teeth in the morning is the same way I wake up every day knowing I'm allergic to peanuts," Anthony said Anthony has a simple message: "Don't live your life being scared." Anthony knows how easy it is for allergies to negatively affect your life I try to live as normal a life as possible," he said In the decades he's had this food allergy Anthony also wants those without food allergies to understand their danger "Ask questions and don't be uncomfortable," Anthony said He would rather someone ask for more information than risk someone's safety Biomedical Discovery and Data-Powered Health Food allergies affect 5 percent of children and 4 percent of adults in the U.S Connect with NLM NLM | NIH | HHS | USA.gov Please press and hold the button until it turns completely green If you believe this is an error, please contact our support team 147.45.197.102 : adcce5b5-de84-4bc8-86d9-1dbe333a Troopers say a person may have been at the scene the morning of December 16 when the collision happened Authorities say 24-year-old Nicholas Terlizzi was drunk when he ran a red light and hit Deputy Oscar Yovani Bolanos Anavisca Junior as he was investigating a robbery If you have any information about a witness you are asked to call SHP the Suffern girls lacrosse team turned the ball over three times in the last few minutes of its Section 1 Class A championship game Thursday against North Rockland which had fallen by only a goal to top-seed Suffern during the regular season had come back from a 7-4 deficit early in the second half to score four straight times to take the lead before Suffern scored twice its second goal coming with fewer than five minutes left in regulation Suffern just needed to control the ball and kill the clock They created pressure and we made bone-headed mistakes," Suffern coach John Callanan said With sophomore goalie Jillian Terlizzi coming up huge with Suffern's season on the line the defending Section 1 champion Mounties held on beating the Red Raiders 9-8 at Nyack High School What it meansNorth Rockland finished its season 14-4 will play the Section 2 Class A champion Tuesday at Schuylerville High School in a semifinal state regional game The Mounties wouldn't be making that trip north if not for the heroics of their young keeper Two came in the game's waning moments against one of the area's top players who'll play next season for Division I Villanova Terlizzi stopped a point-blank shot from Corretjer but Corretjer was fouled from behind on the play and crashed into Terlizzi as both players went down who had nine points in North Rockland's semifinal win over Wappingers and entered the game with 61 goals on the season low shot but Terlizzi reacted quickly and smothered it North Rockland had another chance to score after a Suffern turnover in its defensive end but never got a shot through to Terlizzi with Suffern's defense collapsing on the shooter Girls lacrosse Class D: Defending state champion Bronxville routs top-seed Briarcliff 13-3 Girls lacrosse semifinals: Greeley rules on draw, beats Ursuline 11-8 to advance to Class B final Sophomore Molly Mitchell finished with four goals and an assist for Suffern Included was a goal on a high shot with 9:14 left in the game that knotted the score at 8 after Jillian Fullick had put North Rockland up 8-7 three minutes earlier She carved herself a little piece of history when she whipped a left-handed sidearm shot into the net for not only her third goal but what also proved to be the game-winning goal Caitlin Ruggiero had a goal and an assist and Madison Leale also scored for Suffern Fullick had a hat trick for North Rockland Katie Picarello (whose goal off a hard-nosed drive to the net tied the score 1-1 little more than four minutes into the game) Anna Liquori and Corretjer each scored once who scored after Liquori to tie things 7-7 during North Rockland's 4-0 run who had a terrific stop on a Charlotte Ulman first-half 8-meter try who was on Suffern's junior varsity last year experienced multiple emotions during her first championship sectional game I went to the game very nervous," she said although that didn't seem to have an impact on her shooting "I was kind of just feeling it today," she explained of that Terlizzi questioned a couple of late calls against Suffern and called the game's last few minutes "crazy." Mitchell said it wasn't until 2.7 seconds remained and Suffern was awarded possession of the ball that she knew her team would win "This was supposed to be a rebuilding year "Their defense really stepped up at the right time," North Rockland coach Greg Borchers said of Suffern But he traced the loss back to the first half when North Rockland had possession but failed to capitalize "Their goalie really stepped up when she had to," Corretjer said Reflecting on her time playing for North Rockland "It's an honor and privilege to be part of this program I wouldn't want to be part of any other team." Corretjer said she'd go to Villanova knowing from North Rockland "how to be a really good teammate and put them before me and play for each other." Nancy Haggerty covers cross-country, track & field, field hockey, skiing, ice hockey, basketball, girls lacrosse and other sporting events for The Journal News/lohud. Follow her on Twitter at @HaggertyNancy. Support local news by joining as a member! Receive unfettered access to our digital content, including our Examiner+ bonus content newsletter, and get other perks like free tickets to local performing arts, complimentary advertising for your favorite local charity, restaurant deals, and much more! A 30-year Mount Kisco police veteran who was a vocal critic of the village’s move to consolidate its police services with the Westchester County Department of Public Safety, retired from his position last Thursday. Lt. Louis Terlizzi submitted his retirement letter to Interim Village Manager Jerry Faiella and the village board on July 8. His final day in uniform was July 16. He was one of 24 former Mount Kisco police officers absorbed into the county force on June 1 with their current rank after village and county officials approved the merger. In his letter to village officials, Terlizzi said he made his decision “with deep sorrow and under extreme duress…due to the unprecedented actions taken by both the current Mount Kisco Village Board and various Westchester County Government Officials.” Terlizzi told The Examiner he needed to make his decision about whether to retire by July 16. Under the negotiated terms of the agreement, the former village officers had 30 days from the signing of the consolidation agreement to decide whether they would stay on or retire and maintain their retirement benefits that they had accrued. The signing officially took place on June 16. Terlizzi said that under terms of the merger, if the former village cops failed to work for the county for five years they would lose their health insurance in retirement. In an interview, Terlizzi continued to criticize consolidation, charging that “the officers had enough” after the village failed to negotiate a new contract for the past five years. While he heard no one say that was done intentionally in hopes of encouraging a merger, Terlizzi said that to him “it appeared to be the case.” The consolidation has already led to a loss of services, Terlizzi claimed, because police headquarters on Green Street is no longer open around the clock to the public. “You don’t have that personal attention we used to provide,” Terlizzi said. Mayor Michael Cindrich did not respond to Terlizzi’s comments directly but wished him well in his future endeavors. “I was instrumental in promoting Lou from sergeant to lieutenant,” Cindrich said. “He made a personal choice on retiring and I wish him and his family well.” In the weeks preceding the June 1 merger, Terlizzi and his wife, Kim, strongly opposed the move publicly. The couple said there should have been a public hearing and a referendum, rather than effectively eliminating the village force. Village officials countered that a hearing and referendum were not required because Mount Kisco was merging, not dissolving, its department. We'd love for you to support our work by joining as a free, partial access subscriber, or by registering as a full access member. Members get full access to all of our content, and receive a variety of bonus perks like free show tickets. Learn more here. Copyright © 2025 The Examiner News Funeral services have been announced for the woman killed in the crash on Interstate 80 near Bartonsville Tuesday morning was killed when the 2004 Hyundai Santa Fe her husband was driving veered into a tractor-trailer driven by Baldev Singh it lost control and rolled several times before coming to rest on its roof facing east on the westbound right shoulder Italy she was the daughter of the late Raffaele and Jennie (Amendola) Staiano and the wife of the wife of Giuseppe Terlizzi She was of the Catholic faith and spent most of her years caring for and spending time with her loving family she is survived by two daughters: Antoinette Terlizzi-Manzoni and her husband Leonardo of Long Valley Alessandra Terlizzi-Gomez and her husband Joe of Newark; two grandchildren: Catarina and Daniele Gomez and several nieces and nephews She was preceded in death by three sisters; Marie Lelinho JoAnn Steinfels; and a brother; Enrico Staiano A Mass of Christian burial will be held at 10 a.m Interment will follow at Prospect Cemetery in East Stroudsburg .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Staten Island Advance StaffSTATEN ISLAND a retired butcher who was devoted to his family He moved with his family to Westerleigh as a teenager and settled in Graniteville in 2004 He worked for 36 years as a butcher at Pathmark in Linden He also loved spending time with his family Angelina Troncoso and Lysa Terlizzi; a brother Edith Marone; 27 grandchildren and four great-grandchildren The funeral will be Monday from the Martin Hughes Funeral Home Burial will follow in Calverton National Cemetery Use of and/or registration on any portion of this site constitutes acceptance of our User Agreement, (updated 8/1/2024) and acknowledgement of our Privacy Policy, and Your Privacy Choices and Rights (updated 1/1/2025) © 2025 Advance Local Media LLC. 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ENGINE AND DRIVETRAINInjectorsControl armsBlockFuel PumpSpringsBoreHeadersStrutsStrokeExhaustCaster/CamberDisplacementTransmissionBrakesCrankDriveshaftWheelsRodsRearendTiresPistonsRear SuspensionCompression RatioSpringsELECTRONICSCamEngine ManagementShocksRocker ArmsIgnitionControl armsHeadsGaugesBrakesIntakeWheelsSUSPENSION AND CHASSISThrottle BodyFront SuspensionTiresK-memberMass AirChassis Stiffening Subscribe to our newsletters to get the latest in car news and have editor curated stories sent directly to your inbox DOVER – Two years after launching their own line of e-cigarette liquids from a basement in the Long Valley section of Washington Township a pair of young entrepreneurs are plotting the expansion of their corporation and a move to a larger headquarters weren’t friends while attending West Morris Central High School but they bonded a few years after graduation sharing a passion for vaping and a disenchantment with their college studies Terlizzi was already mixing up his own custom e-liquids and sharing them with friends when he got an order for a menthol blend from an acquaintance who recently had opened two vaping shops That’s when he and Peirson decided to go for it and established their TerraVapes business as a limited liability company “We basically said we don’t have anything to lose so why not try out a business?” said Peirson used vaping to quit a heavy habit of smoking menthol cigarettes They toyed with the idea of opening a retail store in Morristown but quickly learned that was beyond their means So they parlayed about $3,500 in tax refunds and savings into an Internet-based business that focused at first on a grassroots campaign to obtain orders and hand-deliver products to their peers in North Jersey there were no brick-and-mortar shops selling e-liquid or e-cigarettes other than gas stations or Quick Cheks so you had to buy everything online,” Terlizzi said “Buying liquid online was a pretty risky situation because (a website could) say it’s going to taste like a pina colada but it tastes like hand soap (when you receive it).” Their friends in Long Valley and Hackettstown appreciated deliveries of tasty vaping liquids from people they could trust just as the vaping industry was beginning to grow at an exponential rate they grew the business with a new TerraClouds line of premium products featuring 18 flavors ranging from Strawffles (strawberries and waffles) to more exotic-sounding varieties like Jaguar Tears and Mothership Their modest success took a giant leap forward in January with the official launch of their breakthrough line of Sour Batch six flavors with a sweet start and sour-kick finish that they found reminiscent of a favorite candy of their youth with a similar brand name “It was selling three times as many units as our other brands which gave us our ‘Eureka’ moment,” Terlizzi said TerraVapes had moved to a small warehouse space on Bassett Highway in Dover where Terlizzi improvised a small clean room to mix the products he previously had been formulating in his parent’s basement from vegetable glycerin Sour Batch helped them increase sales to 3,000 to 5,000 units per month by the second quarter of 2015 which doubled to about 10,000 units over the past few months and led to them outsourcing product manufacturing to outside contractors although they still pick and ship their orders they plan to move operations to a larger 5,000-square-foot headquarters in Parsippany or somewhere closer to Morristown,” Terlizzi said That move will be accomplished without bank loans or taking on investment partners “We have never taken any credit lines,” Terlizzi said “We grew this ground-up with our own personal savings and equity we put back in We are only paying ourselves a frugal salary and we are both still living at home with our parents Trying to grow equity in our company is our number one priority.” But the Sour Batch “Eureka moment” did not come without its share of controversy While enjoying success with Sour Batch at a big vaping trade show in Florida Peirson was confronted by an angry retailer who objected to them selling a product he felt was designed for appeal to a youth market the currently self-regulating vaping industry was trying to distance itself from Sponsoring an even bigger booth at a summer vaping trade show in Edison they continued to catch flack about Sour Batch marketing this time from industry advocates including the nonprofit “Vaping Militia.” ‘you guys have to start being proactive about yourselves or we’re going to self-regulate you to death,’ ” Terlizzi said Another well-known vaping advocate upped the ante saying if they rebranded to a name with less perceived appeal to the youth market he would promote their product from coast to coast free of charge “We saw it as an opportunity to become the poster child for how to do this properly,” Terlizzi said Sour Batch had been rebranded and trademarked as SOS “Two of our smaller clients refused delivery of the rebranded product,” Peirson said “Vapor products are exclusively marketed to adult consumers,” said Gregory Conley New Jersey president of the American Vaping Association a nonprofit that advocates for small- and medium-sized businesses in the vapor-product market there is no shortage of activists willing to falsely claim that vapor retailers are marketing to children We applaud companies like TerraVapes that are taking close looks at their branding to protect themselves against forces that would like to see the entire vapor industry disappear.” “We’re not in love with the theme of (Sour Batch) “We could have gotten a lot more clients under that brand but it’s going to make our lives so much easier to not be the enemy at conventions.” and outsourcing of formulation to larger facilities with an established FDA-approved Current Good Manufacturing Practice (CGMP) also positions TerraVapes to not only survive Food and Drug Administration issues its long-awaited regulatory guidelines for the vaping industry “Controversy is something our industry doesn’t need more of,” Terlizzi said “There’s already enough drama that can be brought up about any portion of it There’s still lot of guys still out there pridefully stating they are making it and pouring it by hand but we’re at a point in time where companies have to think about their equity in the future.” but companies that are not thinking forward or doing things ethically,” Peirson said of the pending FDA regulations “All that squeeze-bottling and making juice in your kitchen But a lot of people in this business got in it to make a quick buck and get out Just don’t ask the founders of TerraVapes about a buyout “We’re doing something that is kind-of priceless This is our anchor to all the different projects we will be doing.” Staff Writer William Westhoven: 973-917-9242; wwesthoven@GannettNJ.com Prince Albert II spent part of his afternoon in Terlizzi a municipality in Puglia that he visited for the first time in 1997 the Prince is maintaining relations with municipalities that are historically linked to his family A diplomatic visit and a busy schedule. Almost as soon as he arrived in Terlizzi the Sovereign attended the inauguration of a first plaque at the entrance to the town Enscribed “Historic Site of the Grimaldis of Monaco” it symbolises the village’s membership in a network of municipalities that have historic ties to the Principality The Prince’s last visit to Terlizzi was in 1997 when the Prince celebrated 700 years of the Grimaldi dynasty with visiting the territories whose history is intertwined with that of the Lords and Princes of Monaco SEE ALSO: Ambassador Giulio Alaimo: Monaco-Italy relations almost run on their own” The Prince’s journey continued with a visit to the town of Trani and in particular its cathedral The day concluded with a dinner for the Monegasque delegation and the mayors of Trani These properties recently were sold in Darien according to records in the Town Clerk’s Office: —27 Anthony Lane — David Lopiano to Wenyu Xiang and Charles Xu —14 Park Place — David Siever and Tatiana Siever to Gregory Terlizzi and Maura Terlizzi —16 Stonewall Lane — David Bartram and Elizabeth Bartram to Thomas Egan and Meghan Egan —16 Hamilton Lane — Donna Lindsay to Torren Haavik Darien & Rowayton Real Estate Reports: One of nature’s oldest – but diminishing – beach mating rituals is about to begin its annual springtime cycle and The Maritime Aquarium at Norwalk needs volunteers to help document it New Canaan police say residents in that town reported a black bear Tuesday morning just north of the Merritt Parkway in the area of Old Stamford Road (Route 106) Enjoy a guided deep dive into the amazing world of octopuses June 14 as public radio’s “Science Friday” founder and host Ira Flatow celebrates “Cephalopod Movie Night” with a special lineup of films and experts at The Maritime Aquarium at Norwalk Volunteers along coastal communities are needed by The Maritime Aquarium at Norwalk to help collect data on a turtle whose population is of special concern in Connecticut New Canaan police say a cat abandoned amid freezing temperatures at an Interstate 95 rest stop is in need of surgery and rehabilitation Built with the Largo WordPress Theme from the Institute for Nonprofit News Strawberry Mansion takes inspiration from ’80s children’s movies of the co-directors’ youths and in order to accurately capture that VHS feeling the film took an unusual path for a feature film in post-production but at the end of the process we transferred it to film to give it that sort of nostalgic timeless quality of the way I remember movies looking in the ’80s — just graininess,” co-director Kentucker Audley told MovieMaker Maryland-based Colorlab processed Strawberry Mansion‘s 16mm film-out and executive director Vincent Terlizzi told MovieMaker that they do a few each week — but mostly for music videos and shorter content like political ads The company also did a New York Times Super Bowl commercial in 2020 Strawberry Mansion is an ambitious low-budget film that has drawn comparisons to Terry Gilliam and Gilliam’s The Adventures of Baron Munchausen was a major influence The ambitious nature of the narrative played into the film-out decision “We’re throwing so many different time periods and styles into the movie and it feels like it’s a mixture of old and new,” Audley explained “Shooting digitally and transferring to film played into that excitement to mix time periods and styles.” Film-outs are also an important part of film preservation An older damaged film can be restored digitally and then a 35mm film-out will allow a restored physical copy of the film to remain preserved safely in storage Terlizzi said that Travis Scott’s “Franchise” music video was shot on 16mm but also used a few digital drone shots and underwater iPhone shots Those digital segments were processed with a film-out at Colorlab to match the 16mm film stock of the rest of the footage Co-director Albert Birney and Audley would have loved to shoot Strawberry Mansion on film but with a slew of stop animation and special effects “It’s 100 percent cheaper to shoot digitally nowadays,” Birney told MovieMaker “And because we had so many different special effects — there was stop-motion there was some computer animation — all these different kinds it was just going to be easier to do it digitally But I knew that if we transferred it to 16mm it would flatten everything together and make all the effects a little bit more cohesive.” Also read: Strawberry Mansion Directors Albert Birney and Kentucker Audley on Their DIY Adventure Tale’s VHS Roots Terlizzi said that Colorlab is one of only three film labs in the U.S and so the film’s original widescreen 16:9 aspect ratio had to be squeezed into the 4:3 aspect ratio of 16mm This warps the image but offers the desired grain that Birney and Audley were after Then the film was printed onto 400-foot reels of roughly 10 minutes and 40 seconds each Strawberry Mansion used 7203 Kodak 50D film stock for its film-out The 16mm film-out was also a way for Strawberry Mansion to differentiate its look from how familiar indie movies have looked for quite some time “Naturalism has kind of overtaken indie movies probably since the heyday of ’80s movies But it gets tiresome when you see things that look like your ordinary life,” Audley said “By putting it all on an older format and just popping it full of older textures it gives it a little bit more of that nostalgic feel.” Also read: Shooting on 16mm Film in the Digital Age: What You Need to Know If You’re Still Taking Stock in Film Stock Audley said the film also has other small touches that might be imperceivable to a viewer but still added necessary texture we added a slight record player scratch with the same kind of goal in mind to put as much texture and emotion into something that you probably won’t even notice but it gives it an another extra bed of texture,” Audley said Strawberry Mansion premiered in Sundance’s NEXT section. Sundance Film Festival runs through Wednesday Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page.