I spent most of my holidays as a child in Tropea
a quiet but beautiful coastal town in Southern Italy where my family lives
Set in the heart of the "Coast of the Gods" along the Tyrrhenian Sea
Tropea is the epitome of peace and unspoiled charm
Tropea is known for its wide sandy beaches
my favorite of which is Spiaggia della Rotonda
This gorgeous spot is less than a mile from Tropea's main viewpoint
I love watching the sun reflect off the turquoise
The beach is also incredibly clean and quiet
with a few people typically enjoying a walk and local fishers casting their lines
Tropea is home to tons of pubs and <a target="_self" class="" href="https://www.businessinsider.com/best-thing-mexico-city-lunch-at-local-house-2025-3" rel="" data-track-click="{&quot;element_name&quot;:&quot;body_link&quot;,&quot;event&quot;:&quot;tout_click&quot;,&quot;index&quot;:&quot;bi_value_unassigned&quot;,&quot;product_field&quot;:&quot;bi_value_unassigned&quot;}">family-run restaurants</a>
I always stop at Gelateria Mimmo for refreshing and velvety gelato
Visiting this shop allows me to get a taste of every region of Italy
My go-to restaurant is Hostaria Italiana da Nino
a culinary gem that makes exquisite margherita pizzas with buffalo mozzarella
which celebrates Tropea and its flavors with fresh fish recipes
When visiting Tropea, I love <a target="_self" class="" href="https://www.businessinsider.com/which-disney-world-souvenirs-worth-it-former-cast-member" rel="" data-track-click="{&quot;element_name&quot;:&quot;body_link&quot;,&quot;event&quot;:&quot;tout_click&quot;,&quot;index&quot;:&quot;bi_value_unassigned&quot;,&quot;product_field&quot;:&quot;bi_value_unassigned&quot;}">buying souvenirs</a> from small and family-owned stops
Many vendors sell homegrown food and homemade souvenirs
and it's easy to see how proud the locals are of their work
I found a small street stall run by an older merchant who grows Tropea onions
I bought a bundle of them to make frittatas
Though Tropea is known for its beautiful beaches
I immersed myself in Tropea's maritime heritage by stopping at Museo Diocesano
which is known for its unique art exhibitions and paintings linked to Catholicism and the local diocese
Visiting Museo Civico del Mare was another unforgettable experience
I learned a lot about the sea and admired interesting paleontological finds
I also took part in a beautiful Mass at the Duomo of Tropea
also known as the Cathedral of Maria Santissima of Romania
This church was originally built in the 12th century and is now the main gathering place for Catholics in Tropea
The Mass was a once-in-a-lifetime experience
and I watched as people sang while dancing hand in hand
Welcome back to Clattermouuuth’s Music of the Week
curating Rockaway’s music taste one week at a time
I thought it best to recommend an amazing album I discovered this week: “Short Trip to Space” by John Tropea
one of the most exciting ones I’ve heard in a long time
jazz-fusion is a blend of jazz with rock and funk elements—and this album does it extremely well
yet it’s as if you’ve known them all your life
Tropea’s guitar is just one of the many active voices that lead you through this ecstatic journey
“The Funk You See is the Funk You Do,” is my personal favorite
It feels like you’ve experienced a 10-out-of-10 album after just the first song
you’re on a &#8217;70s dance floor; the next
The next track answers that question with a cover of Earth
Wind &amp; Fire’s “Can’t Hide Love,” featuring a much-needed woodwind solo that arguably sounds better than the original vocals (let me know what you think at clattermouuuthrec@gmail.com)
This track is much chiller than the one before it and tells you you&#8217;re in for a wild ride—with plenty of twists and turns
and every song is a sight to see (or hear)
So please—take a “Short Trip to Space” with this album
and website in this browser for the next time I comment
independent news source that provides the Rockaways with a unique voice
The paper is distributed for free throughout the peninsula
and is available online at rockawaytimes.com
and Aerospace Engineering presents the 2024–2025 seminar series featuring Cameron Tropea
a Henry Ford Visiting Professor at Indian Institute of Technology Madras
who will present “Quantitative Hydrodynamics from Trajectory Imaging.” This seminar will take place on Wednesday
in room 104 of the Rettaliata Engineering Center
we experimentally examine the behavior of a free-falling rigid sphere impacting normally onto
and penetrating into a quiescent liquid pool
Observations of the sphere trajectory in time are made using two orthogonally placed high-speed cameras
yielding the velocity and acceleration vector through repeated differentiation of the time resolved trajectories.&nbsp;
a methodology is introduced by which the instantaneous forces acting on the sphere can be derived by tracking the sphere trajectory
we work in a natural coordinate system aligned with the path line of the sphere
the instantaneous lift and drag forces can be separately estimated
This methodology applies to any free body motion.&nbsp;
the forces acting on the sphere can be quantitatively evaluated over the investigated parameter range
These results reveal that when decelerating
the sphere experiences a very high drag force compared with steady flow
This is attributed to an upstream shift of the mean boundary-layer separation
In this context an instability is identified
whereby the instantaneous drag coefficient is positively correlated with the rate of deceleration
the sphere also experiences significant lift force fluctuations
attributed to unsteady and asymmetric wake fluctuations
the trajectories can be reduced to three stages
common for all impact Reynolds numbers and density ratios when expressed in dimensionless form
and deceleration for different impact parameters exhibit an extremely high degree of uniformity when cast in dimensionless form
This offers valuable predictions of how far a sphere penetrates in time and the forces acting on it.&nbsp;
Cameron Tropea graduated from the University of Toronto in engineering sciences
followed by a master’s degree in mechanical engineering (1977)
in Civil Engineering at the Technical University of Karlsruhe (1982) and Ph.D
in Habilitation in Fluid Mechanics at the University of Erlangen-Nürnberg (1991) where he was appointed as professor of fluid mechanics until 1997
This was followed by an appointment as head of the Institute of Fluid Mechanics and Aerodynamics at the Technische Universität Darmstadt
Since 2003 he has been editor-in-chief of the Springer Nature journal Experiments in Fluids and past director of the Center of Smart Interfaces (CSI) from 2007–2014
His research interests include optical measurement techniques in fluid mechanics
interfacial transport and wetting phenomena
He was a member of the Scientific Commission of the Council of Science and Humanities in Germany (Wissenschaftsrat) from 2016–2022
Tropea retired from the TU Darmstadt in April 2020 and presently holds the Henry Ford Visiting Professorship Chair at Indian Institute of Technology Madras and a VAJRA faculty position at Indian Institute of Science Bangalore.&nbsp;&nbsp;
<a href="https://www.iit.edu/about/contact-us" rel="noopener">Contact Us</a>
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(January 4, 2025 8:00 AM ET) Lumen Christi Catholic High School basketball player Luke Tropea says the Titans play a tough schedule, go all out in practice, and spend hours shooting just for one moment in time.
They look to win a state basketball championship in March of 2025.
In a school that has won more than 55 state titles—in just about every sport—basketball has failed to win one since the school&#8217;s inception in the late 1960s.
The Titans are ranked in the top five in most Michigan Division 3 basketball polls this season – depending on who you believe.
“We were ranked No. 1 a year ago but did not realize our goal of winning a state title,” Tropea said. “We are doing what we can to realize that goal.”
Tropea’s father, Josh, is in his third season as Lumen Christi&#8217;s varsity basketball coach and led Milan to a state title more than a decade ago. Young Luke was in elementary school but remembers the feeling of winning it all.
“At that age winning a state title was like winning the Super Bowl,” Tropea said of Milan’s feat.
“All of our goals (this year) come down to March.”
Tropea is having another solid season for the Titans. He is averaging nearly 19 points, five assists, and three steals per game for Lumen Christi. The Titans are 7-0 following last night&#8217;s win over Detroit Loyola.
Known as a shooter his entire high school career, Tropea is shooting 49 percent from the 3-point line.
“Once you get in the game reps and practice harder like you are shooting in a (real) game, shooting 3-point shots become easier,” Tropea said. “There were nights as a sophomore when I didn’t want to shoot the basketball.”
Tropea helped LCCHS advance to a Division 3 regional title in 2024. The Titans lost to Riverview Gabriel Richard in the quarterfinals – one step away from the final four.
This season may be all or nothing for Tropea as he does not expect to play college basketball.
“I want to concentrate on going to a bigger college – the University of Michigan or Michigan State,” he said. “Playing college basketball is such a big commitment … my education is the next step.”
With a 4.0 grade point average at Lumen Christi, he shouldn’t have any trouble getting into either of those schools.
Tropea helped carry the Titans to the state meet in boys&#8217; tennis this past fall. Being the only senior on the team, he had to offer leadership to some of the younger players.
“My goals on the tennis team were to become a better teammate and carry the team to the state tennis finals,” Tropea said. “Playing No. 1 singles meant you don’t have any easy matches.
Tropea has enjoyed the friendships he has garnered from playing sports at Lumen Christi.
“I have built relationships that I will carry over the rest of my life,” Tropea said. “That means the world to me.”
has everything vacationers come to Italy for: History
Lumen Christi players wait for pregame introductions before taking on Northwest on Monday.eingles@mlive.com
.st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By <a class="byline__authorLink" href="https://www.mlive.com/staff/eingles/posts.html" title="Eric Ingles at eingles@mlive.com">Eric Ingles | eingles@mlive.com</a>JACKSON -- The Lumen Christi boys basketball team fell behind early in a game at Northwest on Monday
five lead changes and six players scoring in double figures
“We really haven’t been there this year,” Titans guard Luke Tropea said
“We’ve either lost in a blowout or won in a blowout mostly every game
We really just wanted to press and use our defense to get back in the game because we were struggling offensively.”
The final surge to put the Titans on top came in the final 3:14
That’s when Kash Kalahar found Tropea for a 3-pointer to tie the game at 45-45
After a pair of free throws from Timmy Crowley put Lumen Christi in front
Twice in the closing minutes Hudson Cooper rebounded a missed Mounties free throw
once being fouled in the process and hitting a pair of free throws
the other time hitting a basket in the paint
“I always tell them we’ve got to respond,” Northwest coach James Bradley said
I was proud of the way they responded for the most part.”
Jarrett Osterberg led the Mounties with 19
as the Mounties thrived in a four-in/one-out set offensively
“We just rely on pass-and-cut and rely on guys getting open and catching in rhythm
either drive or take the open shot,” Bradley said
Kadale Williams led the Titans with 18 points
“He finally started going to the rim instead of settling for 3s,” Lumen Christi coach Josh Tropea said
Until late in the game we weren’t making 3s
there’s no way they can stay in front of you
I thought he did a great job of that in the second half.”
Luke Tropea added 15 and Ashton Callan scored 11
Lumen Christi had several patches of cool shooting
including going 3-for-17 from the field in the third quarter
but put the game away with a 13-for-15 shooting performance from the free throw line in the fourth quarter
“A lot of seniors making those shots,” Luke Tropea said
“I think we had four seniors out there and my younger brother
a lot of guys who have been in close games
and guys are used to knocking down shots at the line.”
feeding Williams in the paint early in the second quarter for Lumen Christi’s first lead of the game
then in the fourth quarter finding Callan cutting to the rim to tie the game
“He’s had a phenomenal year,” Luke Tropea said
Northwest shot 18-of-47 from the field and
after not going to the free throw line once in the first half
knocked down 12-of-18 from the line in the second half
The Mounties were also 8-of-20 from 3-point range
with six of those long-range shots coming in the first half
“We’ve been shooting a lot more in practice
but we haven’t been shooting well behind the arc,” Bradley said
Hot long-range shooting early helped the Mounties jump out to a 12-4 lead
with Jarrett Osterberg hitting three 3-pointers in the first three minutes of the game
then assisting on a 3-pointer for Dennis Graham
“We knew Jarrett Osterberg and Jordan could both get hot from 3
then the point guard hit one too and it just started raining 3s,” Josh Tropea said
I thought we did a much better job of that in the second half
Lumen Christi responded with 3-point shooting of its own
then Kadale Williams found Broden Burgess open from long range
Williams hit a 3-pointer later in the quarter
and Kash Kalahar added another moments later to tie the game at 16-16 after one
That was part of a 13-0 Titans run which lasted from late in the first quarter until midway through the second
as Williams opened the second quarter with a three-point play and layups from Callan and Luke Tropea put Lumen Christi ahead 23-16
That stretch of 10 Mountie possessions at the other end saw Northwest shoot 0-for-9 and turn the ball over three times
with Johnathan Osterberg scoring on a spin move in the paint to spark a span of five straight Northwest possessions with a basket
Jarrett Osterberg and Hudson Cooper added layups
and Graham and Jarrett Osterberg hit 3-pointers
Williams and Jalen Jordan traded layups to open the third
and Jarrett Osterberg and Crowley followed that by trading 3-pointers
and Northwest led by as many as seven in the third quarter
and a Williams layup late in the third got the Titans back within five
and early in the fourth Callan hit a pair of layups
the second becoming a three-point play to tie the game at 38-38
Williams hit a layup with 5:51 left to put Lumen Christi on top
but that lead lasted just seconds before a Jordan 3-pointer made it 42-40 Northwest
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From 7 December 2024 to 6 January 2025, Tropea will be transformed into a true ‘’Enchanted Village‘’, a place where the magic of Christmas comes to life amidst glittering illuminations, markets, cultural events and live performances. The unique atmosphere of the historical centre, enhanced by the beauty of the village, will welcome visitors of all ages to celebrate the Christmas holidays together.
Throughout the Christmas period, the village will offer a rich programme, including music, culinary traditions, theatre performances, children's entertainment and the atmospheric live nativity scene. It will be a perfect opportunity to immerse oneself in local traditions, rediscovering the authenticity and warmth of Tropean culture.
There will also be appointments dedicated to music, with concerts ranging from traditional to modern repertoire, and moments of entertainment for families. For those who love tradition, bagpipes and Christmas markets will frame the festivities, providing emotions and scents of times gone by.
Street view</a>Interested<a href="https://calabriastraordinaria.it/en/events/armonie-darte-festival">Multiple eventsArmonie D&#x27;Arte FestivalAug 2, 2024
</a><a href="https://calabriastraordinaria.it/en/places/cathedral-of-maria-santissima-of-romania-tropea">Place of worshipTropea
</a><a href="https://calabriastraordinaria.it/en/places/shrine-of-santa-maria-dellisola-tropea">Place of worshipTropea
</a><a href="https://calabriastraordinaria.it/en/places/historic-centre-tropea">Point of interestTropea
</a>Last update: Jan 6, 2025 6:00 AMContent owned by the Calabria Region | Tourism and Commerce Department issued under CC-BY License
</a><a href="https://www.youtube.com/channel/UCq-pw-Zs8qKid082U_weaUA" target="_blank" title="YouTube" class="cursor-pointer rounded-full p-2 hover:bg-secondary"></a><a href="https://instagram.com/calabria_straordinaria" target="_blank" title="Instagram" class="cursor-pointer rounded-full p-2 hover:bg-secondary"></a><a href="https://calabriastraordinaria.it/en/download" target="_self" class="group flex cursor-pointer items-center justify-start gap-2 rounded-full p-1">Download
OFFICIAL TOURIST INFORMATION SITE © 2022 Calabria Region Tourism and Commerce Department
ALEX GREEN FOR THE SUNDAY TIMES MAGAZINEI am a great enthusiast for the Venice of the Midlands
So I was delighted to receive a message the other day: would I like to go for lunch with Andy Street
when I interviewed him at the last minute because a colleague who was meant to be doing it got stuck on a train
like when I met Andy Burnham and Steve Rotheram
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In Tropea, spring smells of books, culture and reflection. On the occasion of the ‘’May of Books‘’ 2025, the literary review is back, animating the historic centre of the Pearl of the Tyrrhenian Sea with meetings, walks, and presentations: a journey through words and thoughts, this year inspired by Paris, the mythical Trojan prince, symbol of profound choices and authentic desires.
From 23 April to 31 May 2025, the event will transform the city into a veritable cultural workshop, in which authors, popularisers, readers and students will discuss major themes of the present and the past: from immigration to the fight against intolerance, from gender violence to the promotion of territories, including a tribute to symbolic figures of Calabrian culture such as Corrado Alvaro and Franco Costabile.
Street view</a>Interested<a href="https://calabriastraordinaria.it/en/events/siluna-fest">Congress-ConferenceSiluna FestNov 23, 2024
</a><a href="https://calabriastraordinaria.it/en/places/marina-dellisola-tropea">Point of interestTropea
</a>Last update: May 4, 2025 6:01 AMContent owned by the Calabria Region | Tourism and Commerce Department issued under CC-BY License
As a lifelong resident of Italy, I've always been drawn to the country's coastal beauty. Growing up, I was constantly looking to experience iconic maritime cities, from <a href="https://www.businessinsider.com/amalfi-coast-towns-to-stay-in-according-to-local" id="1d0e31c9-7208-4a74-93bd-65152b0243a0">Amalfi</a> to Taormina
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Lumen Christi players huddle during Tuesday&#x27;s regional semifinal against Stockbridge.eingles@mlive.com
.st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By <a class="byline__authorLink" href="https://www.mlive.com/staff/eingles/posts.html" title="Eric Ingles at eingles@mlive.com">Eric Ingles | eingles@mlive.com</a>ITHACA -- Down seven with time ticking down
the Lumen Christi boys basketball team mounted a comeback paced by 3-point shooting and defense to beat Stockbridge 47-44 on Tuesday in a Division 3 regional semifinal
a regional champion on their home floor a year ago
seek to get a second straight trip to the quarterfinal on Thursday when they take on Ovid-Elsie
Back-to-back Zac Rogozinski 3-pointers put the Panthers ahead 41-34 with 3:57 left
But Amarion Clay hit a 3-pointer and Timmy Crowley responded with a layup to get the Titans back within two
After a Shannon Henderson blocked shot led to a run-out and a Noah Sandecki layup
the Titans again chipped away at the deficit as Clay hit another 3-pointer
Ashton Callan fed a ball to Crowley in nearly the same spot
the corner right in front of the Titans bench
and he buried a 3-pointer to put Lumen Christi ahead
“We weren’t making anything all night and they were really long
had a good defensive plan going 2-3 against us,” Crowley said
find someone open and get it through the net.”
From there the Titans defense clamped down
forcing a turnover and not allowing the Panthers to get a shot off with one final possession
“We talked about a recipe of how we could lose this game,” Titans coach Josh Tropea said
but we talked about how we could lose this game if we get into foul trouble and shot poorly
Luke [Tropea] and Timmy had two fouls and did not get into rhythm
and we did not shoot well besides Ashton.”
combined for 37 of the Panthers’ 44 points
Those four and Jacob Dalton had the vast majority of the Panthers&#x27; minutes
rebounding freak,” Stockbridge coach Nate Lott said
they played four quarters in the last five games straight
Callan had 15 points to lead Lumen Christi
Crowley was held scoreless until the fourth quarter and finished with six points
“No rhythm because we had to rotate guys in and out
some lines we haven’t played that much all year
“Those last guys played the whole quarter and getting comfortable with each other.”
Strong 3-point shooting from Amarion Clay and Luke Tropea helped the Titans take an early 6-2 lead
Brock Rochow responded with a basket in the paint and Zac Rogozinski added a 3-pointer to put the Panthers up 7-6
Lumen Christi tied it at 13-13 early in the second on the strength of a Luke Tropea basket in the paint and an Ashton Callan 3-pointer
but a pair of baskets from Henderson re-opened a Panther lead
Clay and Broden Burgess responded with layups late in the half
Then came a wild third quarter with three ties and five lead changes just in that eight minute stretch
Callan hit a 3-pointer and Luke Tropea added a steal and layup to put the Titans ahead
only for Stockbridge to tie it on a Rogozinski 3-pointer
Sandecki added a 3-pointer to put the Panthers up 29-28
A basket from Henderson in the paint and another by Rochow put Stockbridge in front 33-30 at the end of the third
but Callan knocked down a jumper early in the fourth to make it a one-point game
Then came back-to-back 3-pointers from Rogozinski
but then came down and had some bad turnovers
But the Titans were not fazed by the deficit
“I thought we did a better job adjusting on post defense,” Josh Tropea said
“We talked at halftime of doing a better job covering [Rochow’s] left shoulder and not doubling off [Henderson]
Early in the first half [Henderson] got a bunch of easy baskets because we doubled off of him
We wanted to double off the opposite guard and did make a mistake where [Rogozinski] hit a couple big 3s.”
hilltop towns and emerald seas to make fans of Italy swoon
yet this southernmost region remains an undiscovered gem
</a>Let’s start with an exclusive: “Italian town wants more tourists and cruise passengers.” It’s true that many in Italy are fed up with the country’s 22 million annual visitors
and that its most celebrated city has banned cruise liners and makes tourists pay a daily tax
overtourism is not an issue – rather the opposite
is dotted with bars and cafes beneath the walls of a Norman fortress and the dome of a Byzantine church
There’s a small formal garden leading to a terrace with wonderful views – we are more than 300 metres (980ft) high – over the Sila mountain range
Chef Salvatore Vona’s fare is very Calabrian: unfussy
cheap and wonderful (the signature pasta dish is farfalle with yellow peppers and the revered red onions from Tropea
According to the most recent official tourist board figures (from 2022)
the number of UK arrivals in Crotone was 57
I’m sharing the view on this sunny day with Niall Allsopp, Northern Irish by birth, he was a stalwart of the 1990s Madchester scene, and is now a Santa Severina resident and author of <a href="https://www.awesomebooks.com/book/9781533514004/calabria?gad_source=1&amp;amp;amp;gclid=CjwKCAjwvIWzBhAlEiwAHHWgvZqSVcGFt9RCOaHpmkMZ8Q3dal_ohvDGlJXKJNfBWRJKvX_AVvTaDxoCkJEQAvD_BwE" data-link-name="in body link">Calabria: Travels in the Toe of Italy</a>
<a href="#img-3" data-ignore="global-link-styling" aria-hidden="true" tabIndex="-1" class="open-lightbox dcr-13fd1ms">View image in fullscreen</a>Rotonda beach in Tropea
Photograph: Matthijs Borghgraef/Getty ImagesHere’s one view he doesn’t share – the stereotypical perception of Calabria
that’s some way off: Calabria is Italy’s toe
The unification of Italy in 1861 did not unite the country economically
People in the north did well; the many times colonised (Brutti-Bourbon-Greek–Norman-Spanish-Lombard) peninsula of Calabria did not
A classic southern Italian town of formal architecture
This is no Sorrento or Portofino“The Kingdom of the Two Sicilies – everything south of Naples – was the economic hub of what later became Italy,” says Allsopp
“The wealth of the south was transferred north after 1860
It is no coincidence that the mafia came to the fore in the same period.”
Calabria was and is the home of the ’Ndrangheta mob
It has a sign saying: “Qui la ’ndrageta no entra
I comuni calabresi ripudiano la mafia in ogni sua forma.” You get the gist
which is a couple of hours west on the Tyrrhenian Sea
looking out to Sicily and the Aeolian islands
<a href="#img-4" data-ignore="global-link-styling" aria-hidden="true" tabIndex="-1" class="open-lightbox dcr-13fd1ms">View image in fullscreen</a>Piazza Ercole in Tropea
Photograph: Peter Adams/Getty ImagesThe route into Tropea from the north looks like a straight coast road on the map
but the vertiginous cliffs and inaccessible bays force you up and down and round hairpin bends
only to find you are hundreds of feet above the beaches
which are reached by a calf-straining footpath
You look down on pale sand meeting clear emerald water
For those who want sun and sand, hotels 15 minutes from town cost a fraction of the price of similar places in Amalfi: the <a href="https://www.baiadelsole.com/en/index" data-link-name="in body link">Baia del Sol</a>, (doubles from €124 B&amp;B) for example, is great for families, while the plush <a href="https://www.capovaticanoresort.it/" data-link-name="in body link">Capovaticano Spa Thalassotherapy</a> is aimed more at couples (from €260)
a little French and Danish – but no English
Capo Vaticano has sunset views that merit the word epic: volcanic Stromboli
lies ahead; Etna’s perfect peak is to the southJust down the coast
Capo Vaticano has sunset views that merit the word epic: the volcanic island of Stromboli
and far to the south is the perfect peak of Etna in Sicily
lush undergrowth and somewhat sketchy infrastructure
the coast reminds me of the less developed Caribbean islands
The city of Reggio Calabria is an interesting
Visitors to its National Archaeological Museum of Reggio Calabria currently have to settle for looking at its celebrated Riace bronzes
the archaeologists have their laptops and cameras set up while they try to resolve the several mysteries about the figures’ origins
<a href="#img-5" data-ignore="global-link-styling" aria-hidden="true" tabIndex="-1" class="open-lightbox dcr-13fd1ms">View image in fullscreen</a>One of the Riace Bronzes at the National Museum of Magna Grecia, Reggio Calabria. Photograph: AlamyThe museum is well worth a tour, however, as is the restored seafront, named in honour of Italo Falcomatà, the mayor whose 1990s rehabilitation projects, known as the Reggio spring, created the city’s smart new centre in defiance of the mob.
Read more</a>It’s a two-hour drive on the imperfect A3 motorway from Tropea into the mountainous Pollino national park and the<a href="https://www.lalocandadelparco.it/" data-link-name="in body link"> Locanda del Parco</a> agriturismo
From the start we can tell it’s not your usual farm stay
Just beyond the chicken coop sits a dusty London taxi
took a cab ride while he was in England for a conference
and learned from the driver that the vehicle was for sale
He bought it and drove it all the way home
who whisks us straight off to pick some courgettes for lunch
are a defiantly unmodernised clutter of old pictures
odd pieces of furniture and family mementoes
The exception is a spacious suite with sitting room and terrace by the swimming pool: it costs from €160 a night
Rooms in the farmhouse or in a cottage amid olive groves and vegetable patches start at €106
All the food they serve is from the property
Lessons are held in a small room off the main kitchen with a big table
huge bunches of dried chillis hanging from the ceiling and a flipchart announcing what we’ll be preparing for lunch
<a href="#img-6" data-ignore="global-link-styling" aria-hidden="true" tabIndex="-1" class="open-lightbox dcr-13fd1ms">View image in fullscreen</a>Morano Calabro with its Norman castle
Then there are the flowers of the courgettes we picked
fried and stuffed with ricotta (Calabrians love their ricotta)
the sun-dried tomato paste Calabrians put on everything – including the pasta we make with spicy ’nduja
This spreadable salami is the signature taste of Calabria
a bit exotic and very upfront – a bit like the region itself
Nearby Morano Calabro is another hilltop town to make the Chianti classes swoon
The Normans arrived in Calabria six decades before the battle of Hastings
I leave thinking that Calabria is as much a country as a region – and needs more than one return visit
No need to worry about overtourism just yet
‘We’ll stay for just a couple of small plates,’ I told Charles … then ended up having a full-blown
Birmingham: ‘A forward-thinking take on the Italian trattoria’ – restaurant reviewThis article is more than 2 months old‘We’ll stay for just a couple of small plates,’ I told Charles … then ended up having a full-blown
In <a href="https://www.theguardian.com/books/2022/sep/26/a-pocketful-of-happiness-by-richard-e-grant-review-tigger-and-his-one-true-love" data-link-name="in body link">his memoir</a>
Richard E Grant writes about the human need to find “a pocketful of happiness” in every single day – a phrase that came to mind on entering Tropea late last month
and in a roomful of diners defiantly enjoying themselves with gossip
venison ragu tagliatelle and blackberry daiquiris
“We’ll stay for just a couple of plates,” I told Charles
and together they have created a welcoming spot that leans heavily on arty
sunset oranges and flattering soft lighting
This is a restaurant where adventurous mums and dads can treat their student kids to a big £20 plate of gnocchi with gorgonzola dolce and confit red onion
or where mixed groups can catch up semi-noisily over grilled octopus and house red; there’s aubergine parmigiana
and tiramisu for dessert if you want something more recognisably “Britaly”
But Tropea is not in the least painfully “big fish small pond” cool
which helped turn our original order of some very good
an arancino and a small portion of tagliolini into a full-blown
Our plans changed swiftly after the large butternut squash and sage arancino appeared: it was a golden vision
laden with grated provolone and fixed to its spot by a puddle of cheesy butternut sauce
<a href="#img-3" data-ignore="global-link-styling" aria-hidden="true" tabIndex="-1" class="open-lightbox dcr-13fd1ms">View image in fullscreen</a>‘A golden vision’: Tropea’s butternut squash arancino.A portion of rather thickly cut salt-aged beef carpaccio probably did not need the thick
We were back on firmer footing with the house-made pasta
Tropea does not go wild in its choice of pasta – there were only four on offer
and two of those were gnocchi and fregola – but quality
al dente tagliolini with local black winter truffle was a delight
hand-rolled pillows of gnocchi in gorgonzola avoided being one-note by the addition of sweet red onions and a scattering of hazelnuts
Piątkowska and her team run a very good kitchen with a delightful menu
out of its pear tree and in a red-wine sauce
served on parmesan polenta with buttery chanterelles
slightly caramelised slabs of delica pumpkin with whipped ricotta
which was exactly how pumpkin ought to be celebrated
It felt wrong to send any of it back to the kitchen
so I took the last piece home in a box and chopped it over salad for an evening snack
<a href="#img-4" data-ignore="global-link-styling" aria-hidden="true" tabIndex="-1" class="open-lightbox dcr-13fd1ms">View image in fullscreen</a>Tropea’s cannoli are ‘obscenely decadent’.The overall mood that lunchtime was a little sedate
but I’m told more cocktails are drunk and the disco music is turned up of an evening
try lunch – and do try the tiramisu while you’re about it
And please do not be a fool and skimp on the homemade cannoli
you’ll think – they’re so often a disappointment
people might say Birmingham lacks a little by way of la dolce vita
but over in Harborne there’s a place where the imaginary sun shines just that bit brighter
<a href="https://www.tropea.uk/restaurant" data-link-name="in body link">Tropea</a> 27-33 Lordswood Road
Stockbridge and Lumen Christi players and coaches meet with officials before Friday&#x27;s game.eingles@mlive.com
.st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By <a class="byline__authorLink" href="https://www.mlive.com/staff/eingles/posts.html" title="Eric Ingles at eingles@mlive.com">Eric Ingles | eingles@mlive.com</a>JACKSON -- The Lumen Christi boys basketball team kept hitting 3-pointers early in Friday’s game against Stockbridge
and even when the long-range shooting cooled
the Titans were able to hold off the Panthers for a 69-59 win
The Titans were 5-of-8 from long range in the first quarter and 9-of-16 in the first half
Lumen Christi led by as many as 21 in the third quarter
and the Stockbridge surge later could not erase all of that lead
“They were in that zone early and we did a good job moving the ball
made the extra pass,” Titans coach Josh Tropea said
“We found shooters with really good passes.”
Luke Tropea hit 3-pointers on Lumen Christi’s first two offensive possessions of the game
Ashton Callan hit three from 3-point range in the second quarter
and we knew coming over if they shoot the ball well tonight
and they shoot the ball well,” Stockbridge coach Nate Lott said
we see these guys the first round of the regionals.”
Those long-range shots were mostly coming from assists
Timmy Crowley had five assists in the game
three of them in the first quarter alone to set up 3-pointers for Luke Tropea
the Titans had 15 assists on 23 made baskets in the game
and 10 assists on 13 makes in the first half
“That was probably our lowest [assist total] of the year,” Josh Tropea said
“I was pretty frustrated in the second half
I thought that’s where we struggled to score
we saw way too many guys trying to do their own thing.”
Williams finished with 24 points for Lumen Christi
Foster Pybus led the Panthers with 17 points
“He’s pretty strong and pretty good at going to the left.”
Brock Rochow added 14 and Noah Sandecki scored 12
Lumen Christi led 54-34 before a Rochow basket in the paint
“I just thought they fought back hard,” Lott said
“I had a man-to-man chat with them at halftime
we’re stronger than them.&#x27; We just had to take away the 3-pointers
and I thought we came back and hit them in the mouth.”
But Williams answered that with a pull-up jumper
and Crowley followed that by feeding Clay for a basket to put the Titans up 58-42 after three
a lead which grew early in the fourth when Williams added a putback and Clay found Luke Tropea for a 3-pointer
and the Titans didn’t even have the full roster available to practice until the large group of football players concluded their season three weeks ago
“Four games and only 12 practices,” Josh Tropea said
but we’re going to be a roller coaster in December
it’s easy to become a bit of a snob about beaches,&#34; Laura Itzkowitz writes
Laura Itzkowitz is a writer and editor based in Rome
She has been contributing to Travel &#43; Leisure since 2014
when she started as a fact checker before becoming a contributing digital editor in 2015
She has also held positions as a contributing editor at The Points Guy and the NYC cities editor at DuJour Magazine
her writing has appeared in Architectural Digest
When she&#39;s not jetsetting around Italy and beyond
enjoying some cacio e pepe or relaxing at home with her husband and two dogs
Laura moved to New York City in 2011 to pursue a master&#39;s degree in creative writing and translation at Columbia University
She also holds a bachelor&#39;s degree in French from Smith College
* 10&#43; years of experience writing and editing * Co-wrote &#34;New York: Hidden Bars &amp; Restaurants,&#34; an award-winning guide to New York City&#39;s speakeasy scene published by Jonglez Editions in 2015 * Contributed to &#34;Fodor&#39;s Brooklyn,&#34; published by Penguin Random House in 2015
which won silver in the Lowell Thomas Travel Journalism competition * Contributed an essay to &#34;Epic Hikes of Europe,&#34; published by Lonely Planet in 2021 * Updated the 2022 edition of &#34;Fodor&#39;s Essential Italy&#34;
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a beloved figure in his family and community
in Toronto to Antonia &amp; Mario Baschiera
Luciano worked tirelessly to provide for his family
He always put them first and ensured their needs were met
His commitment to the well-being and happiness of his loved ones was unparalleled
Cherished husband of Franca &lsquo;nee Tropea&rsquo; for nearly forty years
Loving father of Alexander (Sarah) &amp; Michael (Kara)
Proud grandfather of Marcus &amp; Gabriella
Reunited in death with his parents Antonia &amp; Mario Baschiera
Dear brother and brother-in-law to Gabriel (Deborah)
He will be lovingly remembered by his nieces &amp; nephews Marco
But the one person who will miss him the most is his &quot;Contessa&quot;
They were inseparable always making plans for the next adventure
A man who loved to travel the world &amp; had an incredible work ethic
He approached life with a deep sense of resilience &amp; determination
He enjoyed the simple pleasures in life and was happiest when enjoying good food
fine wine &amp; whiskey with his beloved family
Luciano&rsquo;s warm heart touched the lives of many
His kind demeanor and genuine care for others earned him a special place in the hearts of both family members and friends alike
He had a generous spirit that extended beyond his immediate family
leaving behind a vast network of loved ones who will forever cherish the memories they shared with him
Luciano Peter Baschiera&rsquo;s legacy will live on through those he leaves behind
Friends and family members are invited to pay their respects during this time
A Funeral Mass will be celebrated on Tuesday
at Transfiguration of Our Lord Catholic Church (45 Ludstone Drive
Etobicoke) Entombment to follow at Prospect Cemetery in Toronto
He will be deeply missed by all who had the privilege of knowing him
and the lasting impact he had on those around him will forever be remembered
C<a href="https://app-hsfdonation.heartandstroke.ca/?pagename=DMDonationForm&s_locale=en_CA&s_fT=cont&s_pres=hsweb&s_cscid=hsweb_nav&gad_source=1&gclid=CjwKCAjwooq3BhB3EiwAYqYoEsfywQloo-S2MlIBR1RFf3cpgRhsC2Unsw5Pagu0G12eHdUwc7bzVRoC4g4QAvD_BwE&gclsrc=aw.ds" target="_blank" rel="noopener noreferrer">lick HERE to donate to Heart &amp; Stroke</a>
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This region in the toe of the Italian boot offers a 'warm welcome'
Calabria, for instance, the toe of the Italian boot, is actually <a data-analytics-id="inline-link" href="https://theweek.com/culture-life/travel/tourists-welcome-the-destinations-open-to-holidaymakers" data-before-rewrite-localise="https://theweek.com/culture-life/travel/tourists-welcome-the-destinations-open-to-holidaymakers">undertouristed</a>
so you can be assured of a warm welcome there
Yet it offers glorious mountain landscapes
and some ancient hilltowns that are quite as ravishing as those further north
its main square would be "thronged" &ndash; but when I visited in early summer
a nearby restaurant serving "very Calabrian" fare ("unfussy
Calabria is known as the home of the 'Ndrangheta Mafia
but locals will tell you which towns it dominates
and they tend to be the "drab" ones that no tourist would opt to visit
The list certainly does not include Santa Severina &ndash; or Tropea
an elegant seaside town perched high above an exquisite beach (pictured).&nbsp;
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via Capo Vaticano (which offers "epic" views of the volcanic island of Stromboli)
Its archaeology museum houses the Riace bronzes
two warrior statues that are among the very few full-size bronze figures to survive from the ancient Greek world.&nbsp;
My final stop was the mountainous Pollino National Park
where I stayed at the Locanda del Parco (a charmingly eccentric agriturismo)
and visited Morano Calabro &ndash; "another hilltop town to make the chianti classes swoon"
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For one week, artists from all over the world will gather in Tropea to paint and create ‘Plein Air’ art amongst the town's picturesque alleys, panoramic views and beaches. The festival will culminate on 13 October with a celebration and exhibition of the works created, which will remain on display until 17 October.
Street view</a>Interested<a href="https://calabriastraordinaria.it/en/events/vinitaly-and-the-city">ExhibitionsVinitaly and the City18 - 20 Jul
</a>Last update: Sep 17, 2024 6:00 AMContent owned by the Calabria Region | Tourism and Commerce Department issued under CC-BY License
Photo of the chef on the cover: Credits Giordano Garosio
magnificent in its landscapes; from the coasts
it is rich in a biodiversity unique in the world
its enormous tourism potential is slowed by the same
well-known problems that plague hospitality throughout the Peninsula
multiplied by a more complex structural situation
This does not detract from the many happy exceptions that are emerging in the area: among them Villa Paola
In the 16th century it was a monastery of the Franciscan order of Friars Minor; now it is a very elegant
Perched on a cliff overlooking the Costa degli Dei
it has a beautiful porch that leads to the common areas and then to a stunning garden with seven terraces
where you can enjoy the tranquility or swim in the infinity pool overlooking the Tyrrhenian Sea and the village of Old Tropea
It is worth coming there even if only to enjoy an aperitif at sunset
since the villa for this is also open to outsiders; at that point
you cannot fail to stop for dinner at De' Minimi Restaurant
this fine dining restaurant is led by the talented Emanuele Pucci
gave us the impression that he is a real rising star and wants to contribute
together with a now large group of colleagues
to raise the culinary level of the region with a dense network of small local suppliers
Emanuele graduated from the Cosenza Hotel Institute
In 2019 I went to the Capo Vaticano Resort
which is under the same ownership as Villa Paola.” From there he moved on to Tuscany
to the Castelfalfi resort : "Like Calabria
that too is a region rich in traditions and important raw materials
If the Tuscan experience with Francesco Ferretti is significant
the months spent at Carlo Cracco's in Milan were crucial: “They left their mark
making me understand many technical aspects and kitchen vision.” At Villa Paola Pucci he returned as a runner-up
he was put in charge of the kitchen: “Last year the company asked me to raise the bar in the direction of a fine-dining project that could make the most of this territory of ours and an idea of sustainability linked to both the use of local raw materials and the minimization of waste.”
making the most of what is the link with his land
because “when I create a dish I want Calabria to be perceived and represented”
96 percent of the ingredients used in the kitchen are regional
with an important share of vegetables and fruits coming from the gardens of the estate that develops around the villa
the excellent wine list also pushes very strongly on Calabrian labels and the important wine tradition of this area
but it is the middle one that best represents his cuisine
Virtue fully outlines our anti-waste philosophy: it was a necessity
it is still a necessity today to combat climate change and reduce environmental impact
hence the name." It starts with the delicate
salted lemon and red turnip: the fish comes from the lakes of the plateau: “A very important piece of Calabria
We accompany them with vegetable products from our garden
recovering as much as possible from the raw material with different preparations.”
and fig leaf oil: the garum is made from a brine of sardine clippings
accompanied by chard extract and fig leaf oil; “it is a dish that reminds me of childhood
when mom often prepared sole with boiled vegetables.”
combined with wild plants and herbs from high altitudes
The spaghettoni in forest broth with chestnuts and hay-smoked butter is very good: born after a walk in the forest
it is an autumn dish with great aromaticity that comes from the broth made with forest herbs and the smoky notes of chestnut and butter
with articulate nuances and a very pleasant savoriness mitigated by the fragrant note of citrus
Again a nice idea with the crépinette of lamb
pomegranate and carrot at BBQ: “A dish that represents the history of the De Minimi restaurant
with a dessert not typically Calabrian: tiramisu in a revised version with technique and taste
De Minimi's selection of Calabrian cheeses is respectable: “During the Middle Ages
monasteries played a key role in the development of dairy products
cheeses were often of poor quality and inadequately preserved
even considered harmful and reserved for the poorer classes
Thanks to the monastic rule and the creativity of the monks
are the organic raw-milk Pecorino cheeses from Masseria de Tursi and the goats' cheeses from the Sant'Anna farm
<a href="https://deminimi.com/" target="_blank">Website</a>
Do you want to discover the latest news and recipes of the most renowned chefs and restaurants in the world
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Volume 15 - 2021 | <a class="ArticleLayoutHeader__info__doi" href="https://doi.org/10.3389/fncel.2021.764761">https://doi.org/10.3389/fncel.2021.764761</a>
Rett syndrome (RTT) and Fragile X syndrome (FXS) are two monogenetic neurodevelopmental disorders with complex clinical presentations
RTT is caused by mutations in the Methyl-CpG binding protein 2 gene (MECP2) altering the function of its protein product MeCP2
MeCP2 modulates gene expression by binding methylated CpG dinucleotides
and by interacting with transcription factors
FXS is caused by the silencing of the FMR1 gene encoding the Fragile X Mental Retardation Protein (FMRP)
a RNA binding protein involved in multiple steps of RNA metabolism
and modulating the translation of thousands of proteins including a large set of synaptic proteins
there are overlapping features in RTT and FXS
possibly due to interactions between MeCP2 and FMRP
and to the regulation of pathways resulting in dysregulation of common molecular signaling
basic physiological mechanisms are regulated by these proteins and might concur to the pathophysiology of both syndromes
Considering that RTT and FXS are disorders affecting brain development
and that most of the common targets of MeCP2 and FMRP are involved in brain activity
we discuss the mechanisms of synaptic function and plasticity altered in RTT and FXS
and we consider the similarities and the differences between these two disorders
Rett syndrome (RTT) and Fragile X syndrome (FXS) are neurodevelopmental disorders associated with mutations in genes located on the X chromosome
the presentation is more severe in male patients
and the reduced severity in females is to be attributed to the presence of two copies of the genes
although X-inactivation influences the number of copies that remain active
and it is an important regulator in brain development
Its altered functionality leads to neurodevelopmental deficits including impaired modulation of brain cell connectivity
Fragile X syndrome affects one in every 4000 males, and one in every 7000 females. The symptoms in male patients with FXS are more severe than in females, and include developmental delays, behavioral and social deficits. FXS patients may show some degree of intellectual disabilities, while females may have normal intelligence to mild intellectual disability (<a href="#B99">Maurin et al., 2014</a>; <a href="#B43">Dahlhaus, 2018</a>)
Despite different molecular etiology and severity of clinical presentation
there are several overlapping symptoms between the disorders: intellectual disabilities
the impairment of synaptic function and plasticity is recognized in both diseases
Several authors, to clarify the neurobiology of RTT and FXS, investigated the molecular targets of MeCP2 and of FMRP (<a href="#B139">Skene et al., 2010</a>; <a href="#B46">Darnell et al., 2011</a>; <a href="#B15">Baubec et al., 2013</a>; <a href="#B100">Maxwell et al., 2013</a>; <a href="#B59">Gabel et al., 2015</a>; <a href="#B133">Rube et al., 2016</a>; <a href="#B98">Maurin et al., 2018</a>; <a href="#B134">Sawicka et al., 2019</a>)
These studies show that many of the targets are involved in neurodevelopment and modulate brain function
here we discuss the similarities and differences between mechanisms of synaptic function and plasticity in RTT and FXS as well as common molecular factors modulated in both disorders
Several sources report a shift in the E-I ratio in both RTT and FXS
however the alterations may differ depending on the brain region or cell-type investigated
Altered synaptic function in Rett syndrome and Fragile X syndrome
Studies in patients-derived cells confirm the decrease excitatory synaptic transmission in iPS cells derived from mice. These results were also observed in mouse preparations in vivo and in vitro (<a href="#B56">Farra et al., 2012</a>)
In FXS mouse models changes to E/I ratio appear to be more specific compared to the Mecp2 KO mice. Increased intrinsic excitability is observed in FXS at cellular, circuit and behavioral level. The cellular excitability stays with altered ion channels activity, dependent both on the translational activity of FMRP, but also on the direct interaction between FMRP and ion channels (<a href="#B40">Contractor et al., 2015</a>)
one aspect of hyperexcitability is linked to the delayed switch in GABA polarity
where the GABA transmission remains excitatory for longer
The overall increased excitability of the circuits influences also synaptic excitability and spike-timing dependent plasticity
and it is dependent on the chloride transporter NKCC1
Another aspect of the increased excitability in FXS is due to a reduced expression of GABAA receptors&#x2019; subunits
The general imbalance in favor of excitation in FXS reflects on the hyper-reactivity to stimuli
and seizures in animal models and patients
Studies in human-derived cells confirmed the morphological findings in FMRP deprived cultures, but they not always confirmed the altered excitability, especially at early stages of development (<a href="#B147">Telias et al., 2015</a>). This discrepancy can be due to an un-matched decrease in FMRP expression during the in vitro development (<a href="#B93">Linda et al., 2018</a>)
Morphological correlates in Rett syndrome and Fragile X syndrome
The long-term activity-dependent variation in synaptic connectivity and the associated molecular changes are defined as synaptic plasticity (<a href="#B37">Citri and Malenka, 2008</a>). Several forms of synaptic plasticity have been reported to be disrupted in RTT and FXS (<a href="#B73">Huber et al., 2002</a>; <a href="#B20">Blackman et al., 2012</a>; <a href="#B158">Wang et al., 2012</a>; <a href="#B108">Na et al., 2013</a>; <a href="#B165">Wondolowski and Dickman, 2013</a>)
Both RTT and FXS display endophenotypes that signal aberrant Long-term potentiation (LTP) and long-term depression (LTD)
AMPA receptor-related transmission is enhanced at hippocampal synapses and over time
the decrease in internalization fails to counterbalance excessive accumulation
the lack of receptor trafficking prevents activated synapses from becoming plastic
Only early induced LTD displays a significant decrease in the amplitude of the response
implicating even earlier synaptic impairment onset in RTT mice
In FXS LTP was reported to be reduced in several brain regions (<a href="#B50">Desai et al., 2006</a>; <a href="#B88">Lauterborn et al., 2007</a>; <a href="#B144">Suvrathan and Chattarji, 2011</a>; <a href="#B136">Seese et al., 2012</a>)
the main form of plasticity studied in FXS is LTD
The first to show alterations in synaptic plasticity in the absence of FMRP were Huber and colleagues (<a href="#B73">Huber et al., 2002</a>), who showed an increase in mGluR-dependent LTD in the hippocampus of Fmr1 KO mice. The dysregulation of mGluR signaling was further confirmed by other authors (<a href="#B161">Weiler et al., 1997</a>; <a href="#B65">Gross et al., 2012</a>; <a href="#B150">Tian et al., 2017</a>)
and all the data support the theory that FMRP controls the translation of specific proteins involved in synaptic function
LTP deficits have been shown in RTT and to a lesser extent in FXS
A summary of the experiments exploring Hebbian forms of plasticity in RTT and FXS is reported in <a href="#T3">Table 3</a>
other forms of plasticity are affected in RTT and FXS
Alteration of long-term potentiation and long-term depression in Rett syndrome and Fragile X syndrome
Homeostatic plasticity controls the changes in synaptic strength that individual neurons operate in response to prolonged changes of neuronal stimulation, and it also mediates the balance of excitation and inhibition. Both RTT and FXS have shown alterations in mechanisms of homeostatic plasticity, and these alterations may explain the general changes in neuronal activity in patients and animal models with RTT and FXS (<a href="#T4">Table 4</a>)
Altered homeostatic plasticity in Rett syndrome and Fragile X syndrome
One of the main mechanisms controlling homeostatic changes is synaptic scaling
Synaptic downscaling &#x2013; the scaling down in response to increased synaptic activity- is also altered in Fmr1 KO mice. One of the mechanisms of downscaling is the degradation of AMPA receptor through ubiquitination (<a href="#B89">Lee et al., 2018</a>)
The ubiquitination of AMPA receptors is mediated by a complex cascade of molecules
which includes cell-cycle molecules and phosphatases
and FMRP interferes with the mechanism that leads to homeostatic-dependent ubiquitination
It is worth of note that the Neuroligin-Neurexin complexes, involved in circuitry development and function is also essential for presynaptic homeostatic plasticity (<a href="#B143">Sons et al., 2006</a>). Several molecular studies in RTT and FXS report that these molecules are targets of FMRP and MeCP2 (<a href="#B46">Darnell et al., 2011</a>; <a href="#B67">Gulmez Karaca et al., 2018</a>; <a href="#B98">Maurin et al., 2018</a>; <a href="#B124">Raman et al., 2018</a>)
suggesting that impaired homeostatic plasticity in these syndromes may be mediated by deficits in Neuroligin or Neurexin
The alteration in several forms of plasticity observed in RTT and FXS can be explained considering that many molecular targets of MeCP2 and FMRP are involved in the regulation of synaptic function. The identification of these molecular regulators can shed light on the neurobiology of RTT and FXS and can suggest strategies for treatment. In this section we will examine several of these molecules and pathways (<a href="#T5">Table 5</a>)
Pathways implicated in Rett syndrome and Fragile X syndrome
but further clinical tests are required to confirm the benefits of the treatment
Both BDNF and IGF1 signals involve the activation of intracellular pathways involving the PI3K and MAPK cascades
which are related to both RTT and FXS and are involved in activity-dependent plasticity
This result suggests a link between the levels of cAMP and cGMP &#x2013; both targets of PDE3 &#x2013; and the levels of IGF-1
PDE4D) and in RETT (PDE4) has been shown to improve socio-cognitive deficits in animal models and in patients
Phosphatidylinositol-3-kinases (PI3K) are a family of intracellular signaling molecules functioning downstream of G protein coupled receptors and tyrosine kinases
suggesting that mechanisms controlling plasticity may be potential targets of therapeutics in FXS and RTT
although the mechanisms of action of NNZ-2566 requires further investigation
It is also worth mentioning that there is a two-way interaction between the systems controlling the production of energy in the cell, and the ion homeostasis (<a href="#B28">Castaldo et al., 2009</a>)
and that such interaction controls the onset and progression of neurodegeneration
These additional mechanisms should be taken into account for uncovering the underlying mechanisms in brain disorders and for designing to routes of treatment
Considering that non-neuronal cells are involved in synaptic function and plasticity, we now discuss the contribution of astrocytes in cellular mechanisms of RTT and FXS (<a href="#T6">Table 6</a>)
Astrocyte function in Rett syndrome and Fragile X syndrome
These studies suggests that MeCP2 deficiency in astrocytes contribute to the RTT phenotype
These results suggest that astrocytes are implicated in neuronal dendritic morphology also in FXS
and foster research that uncover overlapping mechanisms across disorders
our review suggests that the analysis of common and divergent mechanisms controlling synaptic function and plasticity can instruct new criteria for the classification of neurodevelopmental disorders
and SB contributed to the initial draft of the manuscript
All authors discussed and provided the input on the manuscript
DT research is partially supported by: IRSF (3507-207417 grant)
Fondation J&#x00E9;r&#x00F4;me Lejeune (DT Project#1935)
and Science Foundation Ireland (SFI) under Grant Number 16/RC/3948 and co-funded under the European Regional Development Fund and by FutureNeuro industry partners
BB is funded by Agence Nationale de la Recherche ANR-20-CE16-0016 and ANR-15-IDEX-0001
Fondation J&#x00E9;r&#x00F4;me Lejeune (Project #2023)
DT and BB acknowledge the Ulysses Project 2019 (Irish Research Council &#x0026; Ambassade de France en Irlande)
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations
Any product that may be evaluated in this article
or claim that may be made by its manufacturer
is not guaranteed or endorsed by the publisher
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Interregulation between Fragile X Mental retardation protein and Methyl CpG Binding Protein 2 in the mouse posterior cerebral cortex
Hippocampal synaptic plasticity is impaired in the Mecp2-null mouse model of Rett syndrome
Methyl - CpG - binding protein 2 mediates overlapping mechanisms across brain disorders
A synaptic perspective of Fragile X Syndrome and autism spectrum disorders
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Non-cell autonomous influence of MeCP2-deficient glia on neuronal dendritic morphology
Towards a better diagnosis and treatment of Rett syndrome: a model synaptic disorder
Jointly reduced inhibition and excitation underlies circuit-wide changes in cortical processing in Rett syndrome
Methylation-Dependent and -Independent Genomic Targeting Principles of the MBD Protein Family
A novel function for fragile X mental retardation protein in translational activation
Comparative study of brain morphology in Mecp2 Mutant mouse models of Rett syndrome
MeCP2 post-translational modifications: A mechanism to control its involvement in synaptic plasticity and homeostasis
placebo-controlled clinical study of trofinetide in the treatment of Fragile X Syndrome
A critical and cell-autonomous role for MeCP2 in synaptic scaling up
Mild overexpression of Mecp2 in mice causes a higher susceptibility toward seizures
Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome
CREB signaling is involved in rett syndrome pathogenesis
Excitation/Inhibition imbalance and impaired synaptic inhibition in hippocampal Area CA3 of Mecp2 Knockout Mice
CREB controls cortical circuit plasticity and functional recovery after stroke
Identification of FMRP target mRNAs in the developmental brain: FMRP might coordinate Ras/MAPK
Agonist-induced functional analysis and cell sorting associated with single-cell transcriptomics characterizes cell subtypes in normal and pathological brain
Role of the mitochondrial sodium/calcium exchanger in neuronal physiology and in the pathogenesis of neurological diseases
<a href="https://pubmed.ncbi.nlm.nih.gov/23727436" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1016/j.neuropharm.2013.05.018" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=BDNF+in+fragile+X+syndrome%2E&#x0026;journal=Neuropharmacology&#x0026;author=Castr&#x00E9;n+M.+L.&#x0026;author=Castr&#x00E9;n+E.&#x0026;publication_year=2014&#x0026;volume=76&#x0026;pages=729&#x2013;736" target="_blank">Google Scholar</a>
Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome
doi: 10.1146/annurev.pathol.4.110807.092311
The disease progression of Mecp2 mutant mice is affected by the level of BDNF expression
MeCP2 controls excitatory synaptic strength by regulating glutamatergic synapse number
Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes
Deficiency of methyl-CpG binding protein-2 in CNS neurons results in a Rett-like phenotype in mice
Astrocytes and Developmental Plasticity in Fragile X
Mild overexpression of MeCP2 causes a progressive neurological disorder in mice
Abnormal dendritic spines in fragile X knockout mice: maturation and pruning deficits
Altered neuronal and circuit excitability in Fragile X syndrome
Brain protein changes in Mecp2 mouse mutant models: effects on disease progression of Mecp2 brain specific gene reactivation
<a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Brain+protein+changes+in+Mecp2+mouse+mutant+models%3A+effects+on+disease+progression+of+Mecp2+brain+specific+gene+reactivation%2E&#x0026;journal=J%2E+Proteomics&#x0026;author=Cortelazzo+A.&#x0026;author=De+Felice+C.&#x0026;author=Guy+J.&#x0026;author=Timperio+A.+M.&#x0026;author=Zolla+L.&#x0026;author=Guerranti+R.&#x0026;publication_year=2020&#x0026;volume=210&#x0026;issue=103537" target="_blank">Google Scholar</a>
Impaired mitochondrial quality control in Rett Syndrome
Of men and mice: modeling the fragile X syndrome
<a href="https://pubmed.ncbi.nlm.nih.gov/29599705" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.3389/fnmol.2018.00041" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Of+men+and+mice%3A+modeling+the+fragile+X+syndrome%2E&#x0026;journal=Front%2E+Mol%2E+Neurosci%2E&#x0026;author=Dahlhaus+R.&#x0026;publication_year=2018&#x0026;volume=11&#x0026;issue=41" target="_blank">Google Scholar</a>
Reduced cortical activity due to a shift in the balance between excitation and inhibition in a mouse model of Rett Syndrome
<a name="B45" id="B45"></a>D&#x2019;Antoni
Aberrant mitochondrial bioenergetics in the cerebral cortex of the Fmr1 knockout mouse model of fragile X syndrome
FMRP stalls ribosomal translocation on mRNAs linked to synaptic function and autism
as a Potential Therapeutic Agent for Fragile X Syndrome
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders
<a href="https://pubmed.ncbi.nlm.nih.gov/33414502" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1038/s41380-020-00997-9" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Role+of+phosphodiesterases+in+the+pathophysiology+of+neurodevelopmental+disorders%2E&#x0026;journal=Mol%2E+Psychiatry%2E&#x0026;author=Delhaye+S.&#x0026;author=Bardoni+B.&#x0026;publication_year=2021" target="_blank">Google Scholar</a>
FXYD1 is an MeCP2 target gene overexpressed in the brains of Rett syndrome patients and Mecp2-null mice
Early postnatal plasticity in neocortex of Fmr1 knockout mice
Regulation of neuronal survival by the serine-threonine protein kinase Akt
NMDA receptor regulation prevents regression of visual cortical function in the absence of Mecp2
altered antioxidants and NADPH-oxidase activation in brains from Fragile X mental retardation 1-deficient mice
a pathological model for Fragile X syndrome
<a href="https://pubmed.ncbi.nlm.nih.gov/28191346" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.3390/diseases2010045" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=MeCP2-related+diseases+and+animal+models%2E&#x0026;journal=Diseases&#x0026;author=Ezeonwuka+C.&#x0026;author=Rastegar+M.&#x0026;publication_year=2014&#x0026;volume=2&#x0026;pages=45&#x2013;70" target="_blank">Google Scholar</a>
Rett syndrome induced pluripotent stem cell-derived neurons reveal novel neurophysiological alterations
The many faces of insulin-like peptide signalling in the brain
BDNF isoforms: A round trip ticket between neurogenesis and serotonin
Disruption of DNA methylation-dependent long gene repression in Rett syndrome HHS Public Access
memory and psychiatric disorders: focus on c-Fos
Imbalance of neocortical excitation and inhibition and altered UP states reflect network hyperexcitability in the mouse model of fragile X syndrome
placebo-controlled study of trofinetide in pediatric Rett syndrome
Long-term potentiation in the hippocampus of fragile X knockout mice
<a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Long-term+potentiation+in+the+hippocampus+of+fragile+X+knockout+mice%2E&#x0026;journal=Am%2E+J%2E+Med%2E+Genet%2E&#x0026;author=Godfraind+J.+M.&#x0026;author=Reyniers+E.&#x0026;author=De+Boulle+K.&#x0026;author=D&#x2019;Hooge+R.&#x0026;author=De+Deyn+P.+P.&#x0026;author=Bakker+C.+E.&#x0026;publication_year=1996&#x0026;volume=64&#x0026;pages=246&#x2013;251" target="_blank">Google Scholar</a>
Synaptic regulation of protein synthesis and the fragile X protein
Therapeutic strategies in fragile X syndrome: dysregulated mGluR signaling and beyond
<a href="https://pubmed.ncbi.nlm.nih.gov/21796106" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1038/npp.2011.137" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;author=Gross+C.+Berry-Kravis+E.+M.+and+Bassell+G.+J.&#x0026;publication_year=2012" target="_blank">Google Scholar</a>
Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
Adult hippocampal MeCP2 preserves the genomic responsiveness to learning required for long-term memory formation
A mouse Mecp2-null mutation causes neurological symptoms that mimic Rett syndrome
The trouble with spines in fragile X syndrome: density
Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity
Critical period inhibition of NKCC1 rectifies synapse plasticity in the somatosensory cortex and restores adult tactile response maps in fragile X mice
Astrocytic contributions to synaptic and learning abnormalities in a mouse model of Fragile X Syndrome
Altered synaptic plasticity in a mouse model of fragile X mental retardation
Single-molecule imaging of PSD-95 mRNA translation in dendrites and its dysregulation in a mouse model of fragile X syndrome
Dendritic spine structural anomalies in fragile-X mental retardation syndrome
Loss of MeCP2 in parvalbumin-and somatostatin-expressing neurons in mice leads to distinct Rett Syndrome-like Phenotypes
Astrocytes prevent abnormal neuronal development in the fragile X mouse
Dysregulation of Glutamine Transporter SNAT1 in Rett Syndrome Microglia: a mechanism for mitochondrial dysfunction and neurotoxicity
Astroglial FMRP modulates synaptic signaling and behavior phenotypes in FXS mouse model
Learning and memory deficits consequent to reduction of the fragile X mental retardation protein result from metabotropic glutamate receptor-mediated inhibition of cAMP signaling in Drosophila
A human forebrain organoid model of fragile X syndrome exhibits altered neurogenesis and highlights new treatment strategies
<a href="https://pubmed.ncbi.nlm.nih.gov/34413513" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1038/s41593-021-00913-6" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;author=Kang+Y.+Zhou+Y.+Li+Y.+Han+Y.+Xu+J.+Niu+W.+et+al.&#x0026;publication_year=2021" target="_blank">Google Scholar</a>
Excitation control: balancing PSD-95 function at the synapse
and preliminary assessment of efficacy of mecasermin (recombinant human IGF-1) for the treatment of Rett syndrome
MECP2 is progressively expressed in post-migratory neurons and is involved in neuronal maturation rather than cell fate decisions
Deletion of FMR1 in purkinje cells enhances parallel fiber LTD
and attenuates cerebellar eyelid conditioning in fragile X syndrome
<a name="B86" id="B86"></a>Kowia&#x0144;ski
BDNF: a key factor with multipotent impact on brain signaling and synaptic plasticity
The known unknowns: missing pieces in in vivo models of Fragile X Syndrome
<a href="https://doi.org/10.29245/2572-9411/2020/1.1190" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=The+known+unknowns%3A+missing+pieces+in+in+vivo+models+of+Fragile+X+Syndrome%2E&#x0026;journal=J%2E+Rare+Dis%2E+Res%2E+Treat%2E&#x0026;author=Kulkarni+P.&#x0026;author=Sevilimedu+A.&#x0026;publication_year=2020&#x0026;volume=5&#x0026;pages=1&#x2013;9" target="_blank">Google Scholar</a>
Brain-derived neurotrophic factor rescues synaptic plasticity in a mouse model of fragile X syndrome
Loss of fragile X protein FMRP impairs homeostatic synaptic downscaling through tumor suppressor p53 and ubiquitin E3 ligase Nedd4-2
Subregion-specific dendritic spine abnormalities in the hippocampus of Fmr1 KO mice
Excitatory synapses are stronger in the hippocampus of Rett syndrome mice due to altered synaptic trafficking of AMPA-type glutamate receptors
ATP Synthase c-subunit leak causes aberrant cellular metabolism in fragile X Syndrome
The promise of induced pluripotent stem cells for neurodevelopmental disorders
A role for glia in the progression of Rett-syndrome
Early alterations in a mouse model of Rett syndrome: the GABA developmental shift is abolished at birth
Deficient tonic GABAergic conductance and synaptic balance in the fragile X syndrome amygdala
Fragile X mental retardation protein: to be or not to be a translational enhancer
HITS-CLIP in various brain areas reveals new targets and new modalities of RNA binding by fragile X mental retardation protein
Fragile X Syndrome: from molecular pathology to therapy
Chromatin context and ncRNA highlight targets of MeCP2 in brain
Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation
The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo
Mitochondrial dysfunction in Fragile-X Syndrome: plugging the leak may save the ship
Long-Term Memory Engram Cells Are Established by c-Fos/CREB Transcriptional Cycling
Learning and memory and synaptic plasticity are impaired in a mouse model of Rett syndrome
Reversible Inhibition of PSD-95 mRNA Translation by miR-125a
A mouse model for MeCP2 duplication syndrome: MeCP2 overexpression impairs learning and memory and synaptic transmission
The impact of MeCP2 loss-or gain-of-function on synaptic plasticity
Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
MeCP2-dependent transcriptional repression regulates excitatory neurotransmission
Metabolic signatures differentiate Rett syndrome from unaffected siblings
Abnormal development of dendritic spines in FMR1 knock-out mice
Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome
<a name="B114" id="B114"></a>O&#x2019;Leary
Placebo-controlled crossover assessment of mecasermin for the treatment of Rett syndrome
<a name="B115" id="B115"></a>Paluszkiewicz
Impaired inhibitory control of cortical synchronization in fragile X syndrome
Fragile X mouse: strain effects of knockout phenotype and evidence suggesting deficient amygdala function
A target cell-specific role for presynaptic Fmr1 in regulating glutamate release onto neocortical fast-spiking inhibitory neurons
Urokinase plasminogen activator mediates changes in human astrocytes modeling fragile X syndrome
Absence of expression of the FMR-1 gene in fragile X syndrome
The first mecp2-null zebrafish model shows altered motor behaviors
Rett syndrome in males: the different clinical course in two brothers with the same microduplication MECP2 Xq28
Missense mutation of Fmr1 results in impaired AMPAR-mediated plasticity and socio-cognitive deficits in mice
The rett syndrome protein MeCP2 regulates synaptic scaling
Apparent bias toward long gene misregulation in MeCP2 syndromes disappears after controlling for baseline variations
Autism and other neuropsychiatric symptoms are prevalent in individuals with MECP2 duplication syndrome
A Special Extract of Bacopa monnieri (CDRI-08)-Restored Memory in CoCl2-Hypoxia Mimetic Mice Is Associated with Upregulation of Fmr-1 Gene Expression in Hippocampus
Neurotrophin-regulated signalling pathways
<a href="https://pubmed.ncbi.nlm.nih.gov/16939974" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1098/rstb.2006.1894" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Neurotrophin-regulated+signalling+pathways%2E&#x0026;journal=Philos%2E+Trans%2E+R%2E+Soc%2E+B+Biol%2E+Sci%2E&#x0026;author=Reichardt+L.+F.&#x0026;publication_year=2006&#x0026;volume=361&#x0026;pages=1545&#x2013;1564" target="_blank">Google Scholar</a>
Brief report: systematic review of Rett Syndrome in Males
Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model
The molecular biology of FMRP: new insights into fragile X syndrome
Neurotrophic factors in the pathogenesis of Rett syndrome
<a href="https://pubmed.ncbi.nlm.nih.gov/14649551" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1177/08830738030180101101" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Neurotrophic+factors+in+the+pathogenesis+of+Rett+syndrome%2E&#x0026;journal=J%2E+Child+Neurol%2E&#x0026;author=Riikonen+R.&#x0026;publication_year=2003&#x0026;volume=18&#x0026;pages=693&#x2013;697" target="_blank">Google Scholar</a>
Sequence features accurately predict genome-wide MeCP2 binding in vivo
FMRP has a cell-type-specific role in CA1 pyramidal neurons to regulate autism-related transcripts and circadian memory
Mechanisms of functional hypoconnectivity in the medial prefrontal cortex of Mecp2 null mice
LTP induction translocates cortactin at distant synapses in wild-type but not Fmr1 knock-out mice
Dysregulation of mTOR signaling in fragile X syndrome
Fragile X mental retardation protein and synaptic plasticity
<a href="https://pubmed.ncbi.nlm.nih.gov/23566911" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1186/1756-6606-6-15" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;author=Sidorov+M.+S.+Auerbach+B.+D.+and+Bear+M.+F.&#x0026;publication_year=2013" target="_blank">Google Scholar</a>
Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state
Fragile X protein FMRP is required for homeostatic plasticity and regulation of synaptic strength by retinoic acid
Excitation-inhibition balance as a framework for investigating mechanisms in neuropsychiatric disorders
Parvalbumin neurons and gamma rhythms enhance cortical circuit performance
A -Neurexins are required for efficient transmitter release and synaptic homeostasis at the mouse neuromuscular junction
<a href="https://pubmed.ncbi.nlm.nih.gov/21555214" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1016/J.CONB.2011.04.005" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Fragile+X+syndrome+and+the+amygdala%2E&#x0026;journal=Curr%2E+Opin%2E+Neurobiol%2E&#x0026;author=Suvrathan+A.&#x0026;author=Chattarji+S.&#x0026;publication_year=2011&#x0026;volume=21&#x0026;pages=509&#x2013;515" target="_blank">Google Scholar</a>
BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation
MeCP2_e2 partially compensates for lack of MeCP2_e1: a male case of Rett syndrome
Molecular mechanisms regulating impaired neurogenesis of Fragile X syndrome human embryonic stem cells
MAPK cascade signalling and synaptic plasticity
<a href="https://pubmed.ncbi.nlm.nih.gov/14976517" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1038/nrn1346" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=MAPK+cascade+signalling+and+synaptic+plasticity%2E&#x0026;journal=Nat%2E+Rev%2E+Neurosci%2E&#x0026;author=Thomas+G.+M.&#x0026;author=Huganir+R.+L.&#x0026;publication_year=2004&#x0026;volume=5&#x0026;pages=173&#x2013;183" target="_blank">Google Scholar</a>
Dissociation of functional and structural plasticity of dendritic spines during NMDAR and mGluR-dependent long-term synaptic depression in wild-type and fragile X model mice
doi: 10.1038/s41380-020-0821-6 [Epub ahead of print]
Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats
The fragile X mental retardation protein is required for type-I metabotropic glutamate receptor-dependent translation of PSD-95
Partial reversal of Rett Syndrome-like symptoms in MeCP2 mutant mice
Neurotrophic factors in cerebrospinal fluid and serum of patients with Rett syndrome
Zebrafish models of neurodevelopmental disorders: limitations and benefits of current tools and techniques
Identification of a gene (FMR-1) containing a CGG repeat coincident with a breakpoint cluster region exhibiting length variation in fragile X syndrome
Dendritic targeting of short and long 3&#x2032; UTR BDNF mRNA is regulated by BDNF or NT-3 and distinct sets of RNA-binding proteins
<a name="B157" id="B157"></a>Wahlstrom-Helgren
GABAB receptor-mediated feed-forward circuit dysfunction in the mouse model of fragile X syndrome
AMPA receptor trafficking in homeostatic synaptic plasticity: functional molecules and signaling cascades
Identification of an adenylyl cyclase inhibitor for treating neuropathic and inflammatory pain
Autocrine action of BDNF on dendrite development of adult-born hippocampal neurons
Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation
Stimulated emission depletion (STED) microscopy reveals nanoscale defects in the developmental trajectory of dendritic spine morphogenesis in a mouse model of fragile X syndrome
Changes in insulin-like growth factor signaling alter phenotypes in Fragile X Mice
<a href="https://pubmed.ncbi.nlm.nih.gov/27643697" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1111/gbb.12340" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=Changes+in+insulin-like+growth+factor+signaling+alter+phenotypes+in+Fragile+X+Mice%2E&#x0026;journal=Genes+Brain+Behav%2E&#x0026;author=Wise+T.+L.&#x0026;publication_year=2017&#x0026;volume=16&#x0026;pages=241&#x2013;249" target="_blank">Google Scholar</a>
IGF1 potentiates the pro-inflammatory response in human peripheral blood mononuclear cells via MAPK
Emerging links between homeostatic synaptic plasticity and neurological disease
Synaptic circuit abnormalities of motor-frontal layer 2/3 pyramidal neurons in a mutant mouse model of Rett syndrome
Genome-wide analysis reveals methyl-CpG-binding protein 2-dependent regulation of microRNAs in a mouse model of Rett syndrome
mRNA localization: an orchestration of assembly
<a href="https://pubmed.ncbi.nlm.nih.gov/22913533" target="_blank">PubMed Abstract</a> | <a href="https://doi.org/10.1111/tra.12004" target="_blank">CrossRef Full Text</a> | <a href="http://scholar.google.com/scholar_lookup?&#x0026;title=mRNA+localization%3A+an+orchestration+of+assembly%2C+traffic+and+synthesis%2E&#x0026;journal=Traffic&#x0026;author=Xing+L.&#x0026;author=Bassell+G.+J.&#x0026;publication_year=2013&#x0026;volume=14&#x0026;pages=2&#x2013;14" target="_blank">Google Scholar</a>
Dendritic spine dysgenesis in Rett syndrome
EEA1 restores homeostatic synaptic plasticity in hippocampal neurons from Rett syndrome mice
Kinase pathway inhibition restores PSD95 induction in neurons lacking fragile X mental retardation protein
MeCP2 modulates gene expression pathways in astrocytes
Insulin-Like growth factor-1 down-regulates the phosphorylation of FXYD1 and rescues behavioral deficits in a mouse model of Rett syndrome
A new function for the Fragile X Mental Retardation Protein in the regulation of PSD-95 mRNA stability Europe PMC Funders Group
A mouse model of the human fragile X syndrome I304N mutation
Fragile X mental retardation protein modulates the stability of its m6A-marked messenger RNA targets
Cilostazol improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus
Insulin-like growth factor-1 (IGF-1) induces the activation/phosphorylation of Akt kinase and cAMP response element-binding protein (CREB) by activating different signaling pathways in PC12 cells
MeCP2 phosphorylation is required for modulating synaptic scaling through mGluR5
MTOR: from growth signal integration to cancer
Bardoni B and Tropea D (2021) Rett Syndrome and Fragile X Syndrome: Different Etiology With Common Molecular Dysfunctions
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https://www.mediterraneodancefestival.com/</a>From 5 to 19 July 2025, the magic of dance returns to the splendid setting of Tropea, pearl of the Costa degli Dei, with the 33rd edition of the Mediterraneo Dance Festival: one of the most eagerly awaited international events for dancers, teachers, choreographers and enthusiasts.
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The town of Tropea rises above the town&#x27;s port in southern Italy&#x27;s Calabria region
The town is not as well known in North America
but is no secret as a tourist destination among Italians.Tropea Tourism/Supplied
a boutique hotel nestled in the rock cliffs overlooking the sea
my wife and I enjoy a breakfast of fresh bread and pastries
southern Italian cheeses and spicy ‘nduja sausage
I realize I’m conflicted about sharing my experience in the Calabrian seaside town of Tropea
but I worry they will listen and Tropea will no longer be an “undiscovered” Italian gem (at least by most Canadians)
I can’t be the only one to grapple with this sort of dilemma
he emerged from the sea having completed his 12 labours at what is now the Strait of Gibraltar
As he rested on its immense granite cliffs
Tropea offers some of the most welcoming beaches in the Mediterranean
The town of about 6,300 people sits on the Costa degli Dei (Coast of the Gods) on the Tyrrhenian Sea in the Calabrian province of Vibo Valentia
Tropea looks out from atop 70-metre cliffs onto the Gulf of Saint Euphemia
First colonized by the Greeks and later the Romans
some say the name Tropea is derived from “tropaia,” the ancient Greek word for “trophy.” Another legend maintains that Hercules chose the name to honour his nurse – “tropheia” – Juno
There is a rejuvenating alchemy to the place
the rhythm of its narrow streets and the easy charm of its restaurants and people have had a restorative effect
Tropea is also home of the exalted &#x27;Red Queen&#x27;
the &#x27;cipolla rossa&#x27; red onion (above)
Tropea offers some of the most welcoming in the Mediterranean
We spent most of our days on la spiaggia della rotonda
a 15-minute walk from Palazzo Mottola that includes a steep climb down a few hundred steps
It is a public beach with a convivial atmosphere populated by sunworshippers
families with young kids and teenagers kicking around soccer balls
the sand is so soft you simply roll out a towel
but during “border months,” such as May and September and October
That’s one of the attractions – since to Canadians
there is no bad time of year to visit southern Italy
Among Tropea’s many charms is that it is an Italian town that people visit
rather than a town of visitors where Italians work (think Venice)
The Tropeani are proud of their community and exude an insouciant sense of humour
when some puritanical Italian mayors were waging a war against public nude bathing and women who displayed “carnal protuberances,” Tropea city council mocked the prudishness
They passed a law allowing it only by “young women capable of exalting the beauty of the female body.” Then the council quickly revoked it
Tropea is also home to the exalted “Red Queen” – the “cipolla rossa” red onion
Imported to the area by Phoenician sailors more than 4,000 years ago
the onions are cultivated along a 100-kilometre stretch of the coastline near Tropea
cipolle rosse are celebrated annually each July at Tropea’s Red Onion Festival
I enjoyed them at almost every meal and in many different forms – raw
Tropea is walkable and easy to tour on foot with most of its historic attractions located in the town&#x27;s centre.Andrew Clark/The Globe and Mail
Most of its historic attractions are in its centre
among them Cathedral of Maria Santissima of Romania
Two undetonated Second World War bombs sit near its entrance
is credited with preventing them from going off
as well as for shielding Tropea from earthquakes
The Lonely Planet’s guide calls the medieval monastic church Santa Maria dell’Isola
Tropea’s “number-one photo opp.” Perched on what was once a rocky little island
I kept meaning to visit but each time I contemplated it
I went for a swim instead and then sipped a negroni
There are many restaurants and bars offering sunset aperitivo
purchase a few cold drinks and a snack from the Super Mario kiosk and join other celebrants assembled to watch a clementine-orange sunset on the Tyrrhenian Sea
with a view of the Aeolian Islands and Santa Maria dell’Isola on your right
the happy crowd offers up an appreciative round of applause
The nearest airport is Lamezia Terme International (an hour outside Tropea)
Air Transat has direct flights from Toronto to Lamezia
ITA Airways offers less expensive fares on daily flights that connect through Rome to Lamezia
Tropea must be seen from the water. There are many tours and boats for hire at the Porto Turistico. We booked with <a href="https://www.noleggiobarchetropea.it/en/">Nautica Piu</a>
a family-run business with 30 years of experience
We toured along the coast and explored private inlets and beaches
<a href="https://palazzomottolatropea.com/en/palazzo-mottola/">Palazzo Mottola</a> is a stylish hotel with unparalleled views of the sea
<a href="https://www.villapaolatropea.it/it/dimora-storica-tropea">Villa Paola</a>, a five-star boutique hotel, was once a 16th-century monastery and is located just outside of town. Its restaurant, <a href="https://guide.michelin.com/en/calabria/tropea/restaurant/de-minimi?utm_source=tripadvisor&utm_medium=partner&utm_campaign=restaurants">De’ Minimi</a>
is the only dining establishment in the Tropea area mentioned in the Michelin Guide
<a href="https://www.baiadelsole.com/en/index">Baia Del Sole</a> is a nice spot for families with its own private beach and offers a baby disco and gardening for tots
sand sculpting and mosaics workshops for kids and classes in deejaying
archery and Calabrian mask-making for teens
<a href="https://www.ristoranteilconvivio.it/">Il Convivio</a> is a popular spot with delicious menu items
Nicely accompanied by a bottle of Greco di Bianco
Al Pinturicchio is known for seafood dishes
such as grilled swordfish and linguine alle vongole (linguine with clams) and local specialties
Le Delizie Du Monaceu is a traditional cucina Calabrese on Largo Frezza
The menu includes grilled tuna steak with caramelized cipolla rossa and “Spaghetti ammuciato alla Monaceu” with anchovies
At <a href="https://www.instagram.com/explore/locations/431643400745432/pizzeria-vecchio-forno/" target="_blank">Pizzeria Vecchio Forno</a>
pizzas are still cooked in the original oven (the oldest in Tropea)
This local institution was opened in the 19th century and has been run by the De Vita family since 1936
Start with Calabrese antipasti and move on to pizza
The writer was a guest of Villa Paolo and Palazzo Mottola
Neither hotel reviewed or approved the story before publication
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Andrew Clark is a contributing writer for The Globe and Mail
and Director of the Comedy Writing and Performance program at Humber College in Toronto
Andrew has won a gold award and been nominated several times for his writing at the National Magazine Awards
and was nominated for a Governor General's Award for Literary Non-Fiction for his most recent book,A Keen Soldier: The Execution of Second World War Private Harold Pringle
He has written for publications including The Globe and Mail
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The most magical way to experience the Advent season
typical specialities such as the ever-present zeppole (sweet and savoury) and traditional Christmas music brighten up the historic centres and squares of towns and cities
A true celebration for adults and children
Where to find Christmas Markets in Calabria
Below is a list of some locations where you can wander around the typical stands and meet Santa Claus (from the end of November to Epiphany)
Below you can find a list of some of the locations that
offer the fun experience of Christmas Markets in Calabria:
Starting from the Christmas Market of Montalto Uffugo
and the dedicated space near the Municipal Villa
the Christmas Village offers the opportunity to visit the historical centre
similar in itself to a nativity scene perched around the beautiful Shrine and Cathedral of Santa Maria della Serra
among the most famous Baroque churches in Calabria
the elective home of composer Ruggiero Leoncavallo
is a succession of aristocratic palaces with beautiful granite portals and 15th- and 16th-century churches
If you are looking for the magic of Christmas in the city
you can take a tour of the Christmas Markets of Cosenza
distributed among the main squares in the centre and Corso Mazzini
the occasion is perfect to visit the artistic beauties
in particular the MAB - Bilotti Open-air Museum
with its contemporary art sculptures scattered along the city's main street
and spend an afternoon of Christmas shopping
tastings and musical events throughout the festive period
between the imposing Cathedral of Santa Maria Assunta
the historical squares and the narrow streets of the centre
Mancuso Gallery offers visitors a sheltered and comfortable space for festive shopping
as well as the pleasure of lounging among the historic caf&eacute;s
Lovers of Christmas Markets in the province of Vibo Valentia can alternate between two enchanting tourist resorts: Tropea and Capo Vaticano (in the municipality of Ricadi)
which respectively offer stands in the streets of one of The Most Beautiful Villages in Italy
with the magic of a "Christmas with a sea view"
and a rich Christmas Village at the Torre Marrana area
entirely dedicated to exhibitors of Christmas decorations and typical products
with an unmissable "zeppolata" and the possibility of ice skating
the city of Reggio Calabria is organising Christmas events throughout the festive period
with Christmas Markets and Santa Claus Village in the locations of Piazza Duomo
the section in front of the Municipal Villa
The entire city will therefore be festively decorated and ready to offer handicrafts
Christmas gifts and typical products of Christmas in Calabria
https://calabriastraordinaria.it/en/news/christmas-markets-in-calabria
You might be interested in<a href="https://calabriastraordinaria.it/en/news/the-most-beautiful-sea-sunsets-to-see-in-calabria">Living slowThe most beautiful sea sunsets to see in Calabria2024-09-09 09:56:29
</a><a href="https://calabriastraordinaria.it/en/places/mab-bilotti-open-air-museum-cosenza">MuseumCosenza
</a><a href="https://calabriastraordinaria.it/en/places/ruggiero-leoncavallo-museum-montalto-uffugo">MuseumMontalto Uffugo
</a><a href="https://calabriastraordinaria.it/en/places/national-archaeological-museum-reggio-calabria">MuseumReggio di Calabria
</a><a href="https://calabriastraordinaria.it/en/places/historic-centre-montalto-uffugo">Point of interestMontalto Uffugo
</a><a href="https://calabriastraordinaria.it/en/places/church-of-san-pietro-apostolo-ricadi">Place of worshipRicadi
</a><a href="https://calabriastraordinaria.it/en/places/mediterranean-biodiversity-park-catanzaro">Point of interestCatanzaro
</a><a href="https://calabriastraordinaria.it/en/places/marrana-tower-brivadi">Archaeological AreaRicadi
</a><a href="https://calabriastraordinaria.it/en/places/aragonese-castle-reggio-calabria">CastleReggio di Calabria
</a><a href="https://calabriastraordinaria.it/en/places/politeama-theatre-catanzaro">TheaterCatanzaro
</a>Last update: Dec 5, 2024 11:34 AMContent owned by the Calabria Region | Tourism and Commerce Department issued under CC-BY License
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with a combined 52 years of military service
receive the Cincinnatus Award at the annual Youngstown State University Veterans and ROTC Alumni Reunion Dinner 5:30 p.m
The dinner at the Avalon Golf and Country Club in Warren is part of the <a href="https://epay.ysu.edu/C21820_ustores/web/store_main.jsp?STOREID=69&amp;SINGLESTORE=true">YSU Veteran and ROTC Alumni Weekend</a> Sept
sponsored by the YSU Office of Veterans Affairs
The weekend also includes a golf outing on Sunday
benefiting the YSU Department of Military Science
Keynote speaker at the dinner is Major General Johnny K
Receiving the Cincinnatus Award are Richard Tropea and Charles Coleman. The <a href="https://ysu.edu/veterans-affairs/about-us/cincinnatus-award">award</a> honors individuals who have served the nation and returned to civilian life to continue the spirit of service by working or volunteering in areas such as public education
veterans’ organizations and other community endeavors and projects
The award is named after a legendary 5th century Roman patrician
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THUNDER BAY &ndash; How important was Marc Chorney induction into the Northwestern Ontario Sports Hall of Fame
The former NHLer spent last week golfing in Scotland
testing his mettle against the likes of St
and by Saturday he made his way to Thunder Bay
one of four athletes and two builders inducted at the 41st annual induction ceremony
Also entering the hall in 2024 were former Olympian hockey star Haley Irwin
longtime curling and golf coach Karen Saarimaki and coach and educator Lee Batstone
who spent part of four seasons in the NHL with Pittsburgh and Los Angeles
amassing eight goals and 35 points in 210 career games between 1980 and 1984
&ldquo;I didn&rsquo;t put much thought into it
we were inducted into the hall of fame and I thought that would be the end of it
this was a surprise when my phone rang about six weeks ago and Dave Siciliano&rsquo;s name came up,&rdquo; Chorney said
&ldquo;I wasn&rsquo;t sure what was going on
left with just six per cent vision after being diagnosed with Stargardt disease
captured gold in tandem cycling at the 2012 Paralympic Games
and also competed twice for Canada at the winter Paralympics Games
Entering the Northwestern Ontario Sports Hall of Fame is a great way to cap off an outstanding athletic career
who recently travelled to Paris for the 2024 Paralympic Games
&ldquo;It&rsquo;s a wonderful honour to be inducted into the Northwestern Ontario Sports Hall of Fame,&rdquo; Weldon said
but behind all the hard work and the competition was a great community of Thunder Bay and competing and cycling and Nordic skiing
the ski clubs &hellip; and just all the volunteers at competition over the years
I just really appreciated all the support and help.&rdquo;
who excelled in track and football during his high school days at St
winning the 1994 intermediate 71-kilogram title
By 1995 he turned to kickboxing and a year later was crowned the World Kickboxing Association&rsquo;s Canadian amateur welterweight champion
In 2005 he won the International Kickboxing Federation&rsquo;s light heavyweight world title
I was very honoured,&rdquo; he said about learning he&rsquo;d be entering the hall
&ldquo;For me it&rsquo;s kind of for myself
but it&rsquo;s also for my family and all my friends and my fans that supported me over the years
It&rsquo;s kind of nice to have that honour and be able to share it with everybody.&rdquo;
who won the 2010 Manitoba senior women&rsquo;s golf championship and claims multiple Northwestern Ontario Curling Association titles
spent more than 30 years as a teacher and coach at Geraldton Composite High School
passing along her wisdom to generations of student athletes
crediting her father for instilling a love of sport in her at a young age
Batstone taught at Selkirk High School for more than 30 years
coaching everything from football and basketball to track and field
and was a key instigator in the creation of the Northwestern Ontario Secondary School Athletics Association
He also spent more than four decades involved in swimming
was unable to attend Saturday&rsquo;s induction ceremony
<a href="http://www.dougallmedia.com/" style="display:block;margin:5px 0"></a>
the popular neighbourhood restaurant Tropea is back
But fans of the restaurant have been missing out as it temporarily shut for renovation earlier this year &#8211; now it&#8217;s back
Tropea is the creation of Ben Robinson Young and Kasia Piatkowska
who met whilst studying Culinary Arts at the University College Birmingham in 2010
Inspired by a picturesque town on the Calabrian coast (of the same name)
Tropea’s menu is heavily influenced by regional dishes throughout Italy
The intimate <a href="https://secretbirmingham.com/italian-restaurants-birmingham/" rel="noopener noreferrer" target="_self" class="shortcode-outbound-link" data-has-ga="true" data-ga-type="click" data-label="https://secretbirmingham.com/italian-restaurants-birmingham/" data-action="text_cta_2" data-category="click_internal">Italian spot</a> in Harborne (pronounced Tro-Pey-Ah)
is renowned for its Italian street food-inspired menu &#8211; using only the finest
either from Milanese markets or local suppliers
it reopens following an extension into the premises next door
The popular neighbourhood restaurant has added 25 more covers in total
which will enable the team to reserve a number of walk-in tables for regulars and locals alike
The extension also means there’s a new bar for guests to sit at and enjoy a drink beforehand
we are so excited to reopen our doors for friends of Tropea and introduce new faces to the refreshed space
Tropea will remain an intimate and cosy restaurant with the extension allowing us to offer more variety in seating options.”
allowing for new kitchen equipment that will enhance the Tropea experience
The new menu will showcase dishes such as Beef carpaccio
Sardines ‘in soar’ on crostini and Sardinian fregola pasta with chilli and native mussels
To learn more or make a booking head <a href="https://www.tropea.uk/" rel="nofollow noopener noreferrer" target="_blank" class="shortcode-outbound-link" data-has-ga="true" data-ga-type="click" data-label="https://www.tropea.uk/" data-action="text_cta_3" data-category="click_non_sales">here</a>