to the late Nandor “Fred” and Carol Finnegan Turi.  He was a 1996 graduate of the University of Maryland (Go Terps!) and was a Validation Engineer currently employed with QCS on assignment at FUJIFILM Diosynth Biotechnologies.  Prior to this role he spent most of his career working at Pfizer William and Nathan Wright; father-in-law and mother-in-law Brianna and Brooke Thiry; and their beloved family cat and enjoyed many activities with his family and friends.  He loved traveling to the NC beaches and mountains as well as to many tropical locations.  In 2024 he and his family took a special trip to Italy where they made invaluable memories.  George was an avid scuba diver and shared his love of diving with his son George took on the role of one of the loudest cheerleaders while watching his daughter play volleyball (Let’s Go 2-1!).  He enjoyed going to amusement parks and riding roller coasters with both children He loved live music and going to concerts with Alison and family.  George was affectionately known as “Uncle J” by his nieces Brianna and Brooke.  George loved grilling and cooking out for his family and friends and could often be found lounging by the pool with an IPA or bourbon.  He was a jack of all trades always working on home improvement projects and his beautiful smile and infectious laugh will truly be missed A memorial service will be held at 3pm Friday 2025 at O’Quinn-Peebles-Phillips Funeral Home Chapel NC 27546.  The family will receive friends 1:30pm – 3pm prior to the service at the funeral home.     memorials may be donated to a charity or organization of your choice Jersey Number 28Megin TuriPosition: DefenderHeight: 5-7Class: SeniorHigh School:Burnaby CentralHometown: Abbotsford British ColumbiaBioStatsMediaBioBioStatsMediaJunior (2024) In 1989, identification and eradication of trichloroethylene, or TCE, a toxic chemical linked to a cluster of childhood cancers and other horrific incidents, was one of the driving forces behind the establishment of the Toxics Use Reduction Institute at UMass Lowell So prevalent was the use of TCE that 35 years later TURI’s mission remains reducing the use of carcinogens and other toxic substances like it in industrial applications the research institute in downtown Lowell received two U.S Environmental Protection Agency grants totaling $759,250 to implement new technology and industry-based outreach to further its efforts “This endeavor will emphasize the importance of transitioning away from hazardous substances and best practices in cleaning processes,” said TURI Laboratory Director Jason Marshall “We look forward to working with businesses and serving as a central source for information on safer alternatives funded through the Bipartisan Infrastructure Law will establish a Vacuum Degreasing Hub dedicated to identifying optimizing and validating safer alternatives to TCE and other toxic solvents Vacuum vapor degreasing is a cleaning process that operates in a closed system allowing fresh solvent vapors to clean contaminated units While vacuum degreasing systems are common features offered by equipment vendors to potential customers the lab established at TURI will be one of very few facilities to offer independent testing the TURI Vacuum Degreasing Hub is compatible with flammable solvents a new development in vacuum vapor systems which have relied on halogenated solvents in years prior “The Vacuum Degreasing Hub represents a significant step forward in our commitment to advancing toxic use reduction technologies,” said TURI Director Baskut Tuncak TURI aims to prevent pollution and the various diseases and disabilities particularly in disadvantaged communities.” TURI’s Vacuum Degreasing Hub will also provide essential training for potential TCE users in Massachusetts This will include collaboration with pollution prevention groups and industries across New England to provide validation of the cleaning process Aligning with the research institute’s “Drive to Zero” campaign which aims to completely phase out the use of TCE and similar harmful solvents the second grant gives TURI the opportunity to educate about and demonstrate how vacuum degreasing systems have been successfully implemented replacing the use of hazardous solvents funded through the EPA’s State and Tribal Assistance Grants program will be open to companies interested in purchasing vacuum degreasing systems in Massachusetts and the surrounding states TURI hopes to partner with four or five such companies who plan to eradicate the use of TCE and engage Projects under the two grants are slated to commence in early 2025 Map and DirectionsContact Us UMass System Terms of Use and Privacy Policy Accessibility Statement For an optimum web experience we recommend the latest version of Firefox Please use one of the links below to install a supported browser Link IconCopy linkFacebook LogoShare on FacebookXShare on XEmailShare via EmailLink copied to clipboardBanning mobile care in Kensington could lead to amputations A bill proposing a ban on mobile services runs counter to best health-care practices writes street wound care nurse and researcher Eleanor Turi A patient was on the floor of the waiting room of our opioid use disorder clinic his eyes closed tight from the pain pulsing from the wounds on his legs When I asked if he’d like me to change the dressings on his legs he said no because he couldn’t take off his pants I suggested cutting them from the bottom up I gave him supplies to do his own wound care Through my work as a wound care nurse and as a nurse scientist studying wound care delivery I have learned that patients like this one — for confidentiality reasons I’ll refer to him by the initial in his first name and that offering compassionate care is key to healing them an animal tranquilizer known to cause severe wounds These people face the amputation of their limbs and even death from infections if they go untreated » READ MORE: When a state panel rejected $7.5M in opioid settlement spending, it showed how little it understands Kensington’s challenges | Opinion The clinic where I work in Kensington is low-barrier which means people can easily receive care like medications for addiction Many low-barrier care settings are in the street or in mobile vans My mission is to give people like J the best care while making them feel understood and cared for I also work as a researcher studying how to improve the quality and quantity of low-barrier wound care for patients like J I have interviewed 30 wound care providers and recovery specialists (people in recovery from drug use) across Philadelphia and Pittsburgh about what we can do to improve wound care in the community I learned that compassionate harm reduction care — like offering clothing and clean needles — is key to keeping people like J in care it is hard to continually supply these services when funding is tight for small organizations and local policies are constantly changing This is a direct action against people who use drugs and require mobile services to receive the care they need Although this policy was brought forward to address the needs of local residents the bill will not address the root problem of poverty many people who use drugs will be unable to receive preventative wound care leaving their wounds undressed and open for infection leading to complications such as hospitalization It is imperative that Councilmember Lozada and other councilmembers recognize the downstream public health impacts of removing mobile services from Kensington » READ MORE: City Council’s Kensington treatment plan has a big problem. Here’s how to fix it. | Opinion This is not the first or last policy attempting to ban or decrease low-barrier care for people who use drugs and national administrations with varied views on crime it is important to identify ways for community organizations to sustain social services and wound care Medicaid codes are available for billing for low-barrier wound care and could provide a steady stream of revenue to community organizations administrators of low-barrier wound care sites struggle to bill Medicaid for street medicine or mobile services because they do not have the time or scope of practice that allows them to submit Medicaid claims It is important to innovate to increase the uptake of Medicaid billing city-level support could be strengthened to ensure small organizations have the administrative ability to bill for services City-level billing guides as well as regulating the speed of Medicaid payments from managed care organizations — which are often very slow — could help reduce this burden Further, allowing registered nurses to directly bill Medicaid would expand use. Right now, only some providers can bill for Medicaid low-barrier services such as street medicine Registered nurses often work alone in mobile vans or on the street delivering care and they deserve to be paid for the care they are delivering I have not seen J since that day in the clinic about two months ago I have hope for him and his safety because I know this community is incredibly resilient these patients will not need resiliency alone to survive; that they will get the clothes they need that mobile services will go where they are and that a new system will arise to replace the chaos we have now I know and believe our health system and political appointees have the power to prevent unnecessary deaths in Kensington this is America — why are we still struggling to find a pair of pants Eleanor Turi is a nurse and health services researcher in Philadelphia Scientists find that sex is the leading factor explaining differences in hearing sensitivity with women having significantly more sensitive hearing than men Hearing problems are on the rise worldwide and whilst hearing sensitivity is well known to decrease with age little research has been done on the other biological and environmental factors that influence it The team, led by Dr Patricia Balaresque from the Centre for Biodiversity and Environmental Research (CRBE) in Toulouse (France) and including Professor Turi King from the University of Bath (UK) conducted hearing tests for 450 individuals across 13 global populations – Ecuador These populations were selected to capture a wide range of ecological and cultural contexts including underrepresented rural and non-European groups They investigated the sensitivity of the cochlea in the ear looking at how it transmitted brain signals in response to different amplitudes and frequencies of sound by measuring so-called Transient-Evoked Otoacoustic Emissions (TEOAE) It’s already well known that people generally have better hearing in their right ear and that hearing usually declines with age the researchers were surprised by their results on the effects of sex and the environment Their findings, published in the journal Scientific Reports show that hearing amplitude is more influenced by sex than age with women showing an average of two decibels more sensitive hearing than men across all the populations studied The second most significant influence was the environment which not only affected the response to volume but also the range of frequencies of sound perceived People living in forest areas had the highest hearing sensitivity and those living at high altitudes having the lowest environment and language all significantly contribute to the variation in hearing across human groups but it wasn’t clear whether this was due to the whole body being affected by the environment or due to long-term adaptations to varying soundscapes The researchers suggest that people living in forests could have higher sensitivity because they’ve adapted to soundscapes with lots of non-human sounds Or it could be due to being exposed to lower levels of pollution People living at higher altitudes may have reduced sensitivity due to a number of reasons including the impact of lower atmospheric pressure on measurements potential sound reduction in high altitude environments or physiological adaptations to lower oxygen levels The team also found a difference between urban and rural populations with those living in cities having a shift towards higher frequencies possibly due to filtering out low frequency traffic noise Professor King, director of the Milner Centre for Evolution at the University of Bath collected samples from the UK participants whilst in her previous role at the University of Leicester She said: “We know that hearing generally declines with age and that exposure to loud noise and chemicals such as tobacco smoke can damage hearing “We wanted to investigate in more detail what factors shape our hearing and diversity of hearing sensitivities and see how our hearing has adapted to our local environment “We were surprised to find that women had two decibels more sensitive hearing across all the populations we measured and this accounted for most of the variations between individuals “This could be due to different exposure to hormones during development in the womb due to men and women having slight structural differences in cochlear anatomy “As well as having higher hearing sensitivity women also perform better in other hearing tests and speech perception indicating that their brains are also better at processing the information but given the detrimental effect of noise on overall health such as sleep quality and increased cardiovascular disease having more sensitive hearing in noisy environments may not always be a good thing.” said: “Our findings challenge existing assumptions and highlight the need to consider both biological and environmental factors when studying hearing “Identifying drivers behind natural hearing variation will improve our understanding of hearing loss and individual differences in noise tolerance.” Professor King said: “We know that humans are continuing to evolve so the next question is whether our hearing is able to change in response to different environments generally or whether there are genetic adaptations involved.” Professor King discusses the findings in more detail in the Milner Centre for Evolution podcast: How your sex and your environment affect your hearing. has been appointed a trustee of the charity Renowned forensic geneticist and Director of the Milner Centre for Evolution, Professor Turi King has been appointed a trustee of the British Science Association Established in 1831, the British Science Association is a registered charity working to bring people and science together in ways that will have a lasting the association improves young people’s experiences of science in their education; works with community groups and grassroots organisations to provide opportunities to be involved in science; showcases the work of researchers and academics through our events and activities; and advocates for a more inclusive science community The charity is governed by a Council which forms the Board of Trustees Turi takes up her position on 1 March this year As Director of the Milner Centre for Evolution at the University of Bath and Professor of Genetics and Science Engagement at the University of Leicester history and media to bring scientific research to life Her past projects have seen her analysing forensic most notably leading to the identification of the remains of King Richard III Turi said: “As a big part of my career has developed in public engagement in science over the last two decades I’ve been a huge admirer of the British Science Association and their work in this area Their remit is to connect science and society be that through making science more accessible through working with young people or community groups through to organising big events like the British Science Festival and British Science Week two intiatives I’ve been involved with in the past as well as being named a BSA Honorary Fellow in 2016 I’m really passionate about public engagement in science so I’m really looking forward to being part of the work that the British Science Association does and how we can grow that in the future.” Sign up for our daily Newsletter and stay up to date with all the latest news You are receiving this pop-up because this is the first time you are visiting our site You are using software which is blocking our advertisements (adblocker) we are relying on revenues from our banners So please disable your adblocker and reload the page to continue using this site.Thanks The watermelon season is kicking off again at Turi Sina in Rotterdam we will be there even earlier than last year We expect our first containers of watermelons from Senegal in the third week of February," says Yahya Tas The supply of the popular Crimson watermelons from Senegal will continue until the end of April Our well-known brand name 'Sefunique' will be used to package these quality melons." "Although the season started several weeks ago we chose to wait for the melons to reach their optimal quality We believe this decision will enhance quality we will switch to Italian and Moroccan watermelons," says Yahya we have noticed that watermelons from Mauritania are not performing as well mainly due to the impact of climate change on quality This has led to a growing demand for Senegalese watermelons we and our growers have decided to expand cultivation this year." "The melon and watermelon season in Morocco is also facing challenges due to unusual weather conditions and the cold climate is slowing down the harvest This once again underscores the importance of the high-quality melons we import from Senegal We are proud of our products and look forward to providing our customers with the best watermelons this season!" For more information:Sefa Tamgüc / Yahya Tas Turi Sina Tel: +31 085 877 0598[email protected]www.turi sina.nl FreshPublishers © 2005-2025 FreshPlaza.com They Should Have the Same Dual Career Options as Doctors, These Nurse Scientists Say But More Funding and Better Rules Are Needed to Help People Who Are Addicted or Homeless, LDI Experts Say Get the latest Penn LDI news, research, events, and opportunities. This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. This study compared the effects of 10 Hz repetitive magnetic stimulation (rMS) in entorhino-hippocampal tissue cultures from mice and rats, providing insights into the impact of the same stimulation protocol on similar neuronal networks under standardized conditions. These findings demonstrate the critical importance of axon morphology and intrinsic cellular properties in predicting the plasticity effects of rTMS, carrying valuable implications for the development of computer models aimed at predicting and standardizing the biological effects of rTMS. Volume 18 - 2024 | https://doi.org/10.3389/fncel.2024.1374555 Introduction: Repetitive transcranial magnetic stimulation (rTMS) is a widely used therapeutic tool in neurology and psychiatry but its cellular and molecular mechanisms are not fully understood is crucial in experimental and clinical settings It enables meaningful comparisons across studies and facilitates the translation of findings into clinical practice the impact of biophysical properties inherent to the stimulated neurons and networks on the outcome of rTMS protocols remains not well understood achieving standardization of biological effects across different brain regions and subjects poses a significant challenge Methods: This study compared the effects of 10 Hz repetitive magnetic stimulation (rMS) in entorhino-hippocampal tissue cultures from mice and rats providing insights into the impact of the same stimulation protocol on similar neuronal networks under standardized conditions Results: We observed the previously described plastic changes in excitatory and inhibitory synaptic strength of CA1 pyramidal neurons in both mouse and rat tissue cultures but a higher stimulation intensity was required for the induction of rMS-induced synaptic plasticity in rat tissue cultures Through systematic comparison of neuronal structural and functional properties and computational modeling we found that morphological parameters of CA1 pyramidal neurons alone are insufficient to explain the observed differences between the groups Although morphologies of mouse and rat CA1 neurons showed no significant differences simulations confirmed that axon morphologies significantly influence individual cell activation thresholds differences in intrinsic cellular properties were sufficient to account for the 10% higher intensity required for the induction of synaptic plasticity in the rat tissue cultures Conclusion: These findings demonstrate the critical importance of axon morphology and intrinsic cellular properties in predicting the plasticity effects of rTMS carrying valuable implications for the development of computer models aimed at predicting and standardizing the biological effects of rTMS the current understanding of the dose–response relationship governing rTMS-induced synaptic plasticity remains limited it is currently also not possible to compute and standardize synaptic plasticity induction across brain regions and subjects This study employed a cross-species analysis to elucidate the effects of 10 Hz repetitive magnetic stimulation (rMS) on CA1 pyramidal neurons in mouse and rat entorhino-hippocampal slice cultures (c.f., Vlachos et al., 2012; Lenz et al., 2016; Eichler et al., 2023) underscored by the well-documented connectivity and plasticity of the CA1 region This approach allowed for an exploration of highly standardized rMS conditions on synaptic plasticity induction in two similar yet distinct neuronal networks We found that CA1 pyramidal neurons in rat slice cultures required a 10% stronger intensity (measured by maximum stimulator output MSO) than those in mice for the induction of plasticity Leveraging multiscale single-cell modeling with axon morphology reconstructions our findings indicate that neuronal morphology alone does not predict rTMS-plasticity thresholds axon morphologies significantly affect individual cell activation thresholds across species Differences in intrinsic cellular properties were sufficient to account for the 10% higher intensity required for the induction of synaptic plasticity in the rat tissue cultures intrinsic cellular properties are crucial in determining the effects of rTMS on plasticity These findings highlight the significance of considering morphology and intrinsic properties for computerized predictions of activation thresholds and standardization of rTMS-induced synaptic plasticity Mice and rats were maintained in a 12 h light/dark cycle with food and water ad libitum Every effort to minimize the distress and pain of animals was made All experimental procedures were performed according to the German animal welfare legislation approved by the appropriate animal welfare committee and the animal welfare officer of the University of Freiburg Mice of the strain C57BL/6J and rats of the strain Wistar (Crl:WI) of both sexes were used in this study Organotypic tissue cultures were prepared from mice and rats of both sexes at postnatal day 3–5 and allowed to mature for 3 weeks in a humidified atmosphere prior to experimental assessment Cultures were stimulated in a standard 35 mm petri dish with rMS (10 Hz 900 pulses); sham-stimulated cultures underwent the same handling but without stimulation Whole cell voltage-clamp and current-clamp recordings were conducted 2–4 h after stimulation High density microelectrode array (HD-MEA) recordings and current-clamp recordings were also performed on non-stimulated slice cultures to determine species-specific differences CA1 pyramidal neurons from non-stimulated tissue cultures were post hoc stained and reconstructed using Neurolucida 360 (ver These reconstructions were utilized for multiscale single-cell modeling 300 μm thick organotypic tissue cultures containing the hippocampus and the entorhinal cortex were prepared at postnatal day 3–5 from mice and rats of either sex as described previously (Vlachos et al., 2012; Galanis et al., 2021) The tissue cultures were maintained in an incubator at 35°C with 5% CO2 for at least 18 days before any experimental assessment Tissue culture medium was changed 3 times per week and consisted of 50% (v/v) MEM 25% (v/v) heat-inactivated normal horse serum and 2 mm Glutamax (pH 7.3 with HCl or NaOH) Tissue cultures were transferred in a standard 35 mm petri dish filled with standard extracellular solution (129 mM NaCl preheated to 35°C; 365 mOsm with sucrose) A 70 mm figure-of-eight coil (D70 Air Film Coil Magstim) connected to a Magstim Super Rapid2 Plus1 (Magstim) was placed 1 mm above the lid of the petri dish and the cultures were stimulated with a protocol consisting of 900 pulses at 10 Hz Tissue cultures were orientated in a way that the induced electric field within the tissue was approximately parallel to the dendritic tree of CA1 pyramidal neurons Species- and time-matched cultures were not stimulated but otherwise identically treated served as the controls Whole-cell voltage-clamp recordings of CA1 pyramidal cells were conducted as previously described (Vlachos et al., 2012; Lenz et al., 2016; Galanis et al., 2021) The bath solution contained 126 mM NaCl and 10 mM glucose and was saturated with 95% O2/5% CO2 Miniature α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor-mediated excitatory postsynaptic currents (mEPSCs) were recorded in the presence of 10 μM D-APV and 0.5 μM TTX in the bath solution while the patch pipettes contained 126 mM K-gluconate and 0.1% (w/v) biocytin (pH 7.25 with KOH Miniature inhibitory postsynaptic currents (mIPSCs) were recorded in the presence of 0.5 μM TTX and 10 μM CNQX in the bath solution while the patch pipettes contained 125 mM CsCl 0.1 mM EGTA and 10 mM HEPES (pH = 7.33 with CsOH; 275 mOsm with sucrose) Neurons were recorded at a holding potential of −70 mV Series resistance was monitored in 2–4 min intervals and recordings were discarded if the series resistance reached ≥30 MΩ and the leak current changed significantly Whole-cell current-clamp recordings of CA1 pyramidal cells were conducted at 35°C and 10 μM bicuculline methiodide and was saturated with 95% O2/5% CO2 Patch pipettes contained 126 mM K-gluconate Neurons were hyperpolarized with −100 pA and then depolarized up to +400 pA with 1-s-long 10 pA current injection steps Recordings were discarded of the series resistance reached ≥15 MΩ HD-MEA recordings of mouse and rat tissue cultures were conducted at 35°C The bath solution was similar to the one used for voltage-clamp recordings without the addition of any drugs Cultures were placed on an Accura HD-MEA chip (3Brain Switzerland) and acclimatized for 2 min before recording Each tissue culture was recorded for 10 min with a BioCAM DupleX (3Brain CA1 pyramidal cells were reconstructed using Neurolucida 360 (ver. 2019.1.3; MBF Bioscience) as described previously (Shirinpour et al., 2021) Somata were reconstructed in 2D using the contour method in order to avoid overestimation of soma volume due to the somatic whole cell recording method used to fill the cells and the high signal intensity of these compartments was extracted from the volume compartment of the tissue culture Reconstructions were imported into the NeMo-TMS pipeline and endowed with a Jarsky model (Jarsky et al., 2005) When axons are “swapped,” the original axon is removed from the cell at the point of intersection with the soma or dendrite and replaced with the axon of another cell that has been severed at the same point Each cell is oriented with the apical dendrite pointing in the positive y direction and axon orientations relative to this are preserved in the swapping process TMS is simulated as a uniform electric field of varying intensity with the threshold defined as the smallest TMS amplitude that elicits a somatic action potential Analyses were performed with the person analyzing the data blind to the experimental condition we used one or two tissue cultures from each animal Electrophysiological data were analyzed using pClamp 11.2 software suite (Molecular Devices) the Easy Electrophysiology 2.5.0.2 (Easy Electrophysiology Ltd.) and BrainWave (3Brain) software Statistical comparisons were made using Mann–Whitney test (to compare two groups) two-way ANOVA and Kruskal-Wallis test as indicated in the figure captions and text (GraphPad Prism 7) p values of <0.05 were considered a significant difference All values represent mean ± SEM Confocal image stacks were exported as 2D projections and stored as TIFF files Figures were prepared using Photoshop graphics software (Adobe) Image brightness and contrast were adjusted 10 Hz repetitive magnetic stimulation (rMS) induces synaptic plasticity in mouse CA1 pyramidal neurons (A) Schematic illustration of the experimental setting Organotypic tissue cultures are stimulated in a standard 35 mm petri dish filled with extracellular solution using a 70 mm figure-of-eight coil (900 pulses (B) Overview of an organotypic tissue culture Visualization of cytoarchitecture with DAPI (C) Patched CA1 pyramidal neurons filled with biocytin and identified post hoc with streptavidin-A488 (D,E) Sample traces and group data of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) recorded from mouse CA1 pyramidal neurons in sham-(control) and rMS-stimulated cultures 2–4 h after stimulation (control n = 28 cells; Mann–Whitney test) (F,G) Sample traces and group data of GABA receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) recorded from mouse CA1 pyramidal neurons in sham-(control) and rMS-stimulated cultures 2–4 h after stimulation (control n = 14 cells; Mann–Whitney test) Individual data points are indicated in this and the following figures by gray dots **p < 0.01 In a different set of cultures, we assessed 10 Hz rMS-induced changes in GABA receptor mediated mIPSCs onto CA1 pyramidal neurons using the experimental approach described above. A reduction in mean mIPSC amplitude was observed in these experiments as reported in our previous study (Figures 1F,G; c.f., Lenz et al., 2016) These results confirm the robust effects of 10 Hz rMS on mEPSC and mIPSC amplitudes of CA1 pyramidal neurons in mouse entorhino-hippocampal tissue cultures which are consistent with a potentiation of excitatory synapses and a depression of inhibitory synapses 10 Hz repetitive magnetic stimulation (rMS) at 50% maximum stimulator output fails to induce synaptic plasticity in rat CA1 pyramidal neurons (A) Overview images of a mouse and rat organotypic tissue culture (B) Patched rat CA1 pyramidal neuron filled with biocytin and identified post hoc with streptavidin-A488 (C,D) Sample traces and group data of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) recorded from rat CA1 pyramidal neurons in sham-(control) and rMS-stimulated cultures 2–4 h after stimulation (control n = 71 cells; Mann–Whitney test) (E,F) Sample traces and group data of GABA receptor-mediated miniature inhibitory postsynaptic currents (mIPSCs) recorded from rat CA1 pyramidal neurons in sham-(control) and rMS-stimulated cultures 2–4 h after stimulation (control n = 9 cells; Mann–Whitney test) We conclude that simulation-based standardization of electric fields may not suffice to achieve comparable biological effects in mouse and rat CA1 pyramidal neurons in neurons embedded in networks with comparable architectures and properties Modeling of electric fields in mouse and rat tissue cultures (A) Visualization of the macroscopic electric field simulations from magnetic stimulation in vitro (B) Three-dimensional mesh models of mouse and rat tissue cultures and the electric fields generated by a single magnetic pulse (C) Comparison of the maximum electric field generated at distinct stimulation intensities in mouse and rat tissue cultures The electric field generated in mouse slice cultures at 50% maximum stimulator output is attained with 53% maximum stimulator output in rat tissue cultures (D) Group data of AMPA receptor-mediated mEPSCs recorded 2–4 h after stimulation from rat CA1 pyramidal neurons in sham-(control) and rMS-stimulated cultures; stimulation at 53% maximum stimulator output (control n = 12 cells; Mann–Whitney test) We conclude that baseline network activity is not responsible for the inability of rMS to induce plasticity in rat CA1 pyramidal neurons No significant differences in baseline network activity in mouse and rat tissue cultures (A,B) Overview images of mouse and rat tissue culture on high-density microelectrode array chips (C) Raster plots of spikes during a 10 min recording period in mouse and rat tissue cultures (D–F) Group data of mean firing rate and mean field potential rate from mouse and rat tissue cultures (mouse n = 5 cultures; Mann–Whitney test) To investigate whether differences in CA1 pyramidal neuron size and complexity could explain the variation in rMS outcome, we reconstructed biocytin-filled and streptavidin-A488 stained CA1 pyramidal neurons from both rat and mouse hippocampal tissue cultures and analyzed their dendrites and axons (Figure 5) This was motivated by the observation that the brain sizes of mice and rats No significant morphological differences of CA1 pyramidal neurons in mouse and rat tissue cultures (A) Examples of patched and biocytin-filled rat CA1 pyramidal neurons identified post hoc with streptavidin-A488 (B) Examples of three-dimensional neuronal reconstructions of mouse and rat CA1 pyramidal neurons (C–H) Group data of mouse and rat apical and basal dendrites (mouse n = 11 cells; statistical comparisons for panels (C,D,G,H) were performed with Mann–Whitney test; statistical comparisons for panels (E,F) were performed with 2-way ANOVA) (I) Rat CA1 pyramidal neuron patched and filled with biocytin identified post hoc with streptavidin-A488 and used for comprehensive neuronal reconstruction encompassing dendritic and axonal neuronal structures (J–L) Group data of mouse and rat axons [mouse n = 6 cells; statistical comparisons for panels (J,L) were performed with Mann–Whitney test; statistical comparisons for panel (K) were performed with 2-way ANOVA] that structural properties of CA1 pyramidal neurons are not statistically different and cannot explain why the rat tissue cultures do not respond to 10 Hz rMS even when the E-field is closely matched based on E-field simulations We assessed the impact of rMS on CA1 pyramidal neurons through a multiscale computational model that connects the physical input parameters of rMS to dendritic and axonal morphologies (Figure 6) This approach was necessary because our morphological analysis might not have encompassed distinctions pertinent to the neuronal activation induced by rMS Multiscale single-cell modeling of electromagnetic stimulation to electromagnetic stimulation were modeled in realistic dendritic and axonal morphologies from reconstructed mouse and rat CA1 pyramidal neurons (B) Group data of realistic dendritic morphologies with a standardized artificial axon (mouse n = 6 cells; Mann–Whitney test) (C) Group data of simulations with realistic dendritic and axonal morphologies (mouse (D) Group data for mouse and rat CA1 pyramidal neurons categorizing those with axons exhibiting lowest (left) and highest (right) rMS depolarization thresholds (mouse n = 6 cells; Kruskal-Wallis test) the dissimilarity in rMS-triggered plasticity between mouse and rat tissue cultures remained unresolved eluding a complete explanation based solely on the interactions of dendritic and axonal morphologies Next, active and passive membrane properties were recorded from CA1 pyramidal neurons and analyzed. Indeed, this set of experiments identified significant differences in the passive and active properties between mouse and rat CA1 pyramidal neurons (Figure 7) Rat CA1 pyramidal neurons exhibit lower excitability in comparison to mice (A) Sample traces from input–output recordings of CA1 pyramidal neurons of mouse and rat tissue cultures (B,C) Group data of resting membrane potentials and input resistances from mouse and rat CA1 pyramidal neurons (mouse n = 56 cells; Mann–Whitney test) (D,E) Group data of action potential (AP) amplitude and threshold from mouse and rat CA1 pyramidal neurons (mouse (F) Current/frequency curve of CA1 pyramidal neurons of mouse and rat tissue cultures (mouse ***p < 0.001 the current–voltage (I/V) curves demonstrated that depolarizing mouse CA1 pyramidal neurons required less current compared to those in rat slice cultures shows that current injections produced stronger responses in mouse CA1 pyramidal neurons than in rat neurons higher action potential frequencies at a lower current injection These results indicated that mouse CA1 pyramidal neurons are more excitable than rat neurons suggesting that higher stimulation intensities may be needed to induce rMS-induced plasticity in rat tissue cultures These results demonstrate that rat CA1 pyramidal neurons do express rMS-induced plasticity but require a higher stimulation intensity for rMS-induced potentiation of excitatory synapses and depression of inhibition to occur 10 Hz repetitive magnetic stimulation (rMS) at 60% MSO induces synaptic plasticity in rat CA1 pyramidal neurons (A) Group data of AMPA receptor-mediated miniature excitatory postsynaptic currents (mEPSCs) recorded from rat CA1 pyramidal neurons from sham-(control) and rMS-stimulated cultures (control n = 16 cells; Mann–Whitney test) (B) Sample traces and group data of miniature inhibitory postsynaptic currents (mIPSCs) recorded from rat CA1 pyramidal neurons from sham- (control) and rMS- stimulated cultures (control n = 17 cells; Mann–Whitney test One data point outside of axis limits in mIPSC amplitude and frequency respectively) we explored the factors influencing the threshold for 10 Hz rTMS-induced synaptic plasticity Using mouse and rat entorhino-hippocampal slice cultures we confirmed the well-known potentiation of excitatory synapses and depression of inhibitory synapses highlighting robust rTMS-induced synaptic plasticity under controlled conditions despite similar neuronal morphology and network activity in rat CA1 pyramidal neurons standardizing electric fields through prospective modeling did not produce the same biological effect Adjusting the stimulation protocol to account for rat neurons’ lower excitability led to comparable synaptic changes These results emphasize that electric field standardization alone cannot predict rTMS effects necessitating realistic compartmental models of cellular properties in different brain regions for accurate predictions The findings from this cross-species study present experimental evidence underscoring the insufficiency of meticulous experimental standardization and electric field modeling in guaranteeing robust biological effects of rTMS computational modeling showed weaker induced electric fields in rat tissue cultures despite their size difference compared to mouse tissue cultures Even when efforts were made to match electric fields the plasticity effects in rat cultures could not be reproduced our investigation revealed no significant differences in axons of cultured CA1 neurons between mice and rats This finding suggests that the observed inability of rat CA1 neurons to exhibit synaptic plasticity cannot be trivially attributed to differences in axon morphology the impact of network activity on the outcome of rTMS must be considered These factors collectively underscore the multifaceted nature of the processes involved in influencing and modulating the outcomes of rTMS-induced plasticity Organotypic slice cultures serve as valuable tools for investigating these and other aspects of rTMS-induced plasticity highlighting the necessity for rigorously validated computer models that link the induced electric fields with biophysically realistic neurons and networks These models hold the potential to predict the biological outcomes of rTMS offering valuable insights into its effects and guiding the adaptation of stimulation protocols to achieve consistent desired effects across different brain regions and individuals The raw data supporting the conclusions of this article will be made available by the authors The animal study was approved by Animal welfare officer of the University of Freiburg The study was conducted in accordance with the local legislation and institutional requirements The author(s) declare financial support was received for the research The work was supported by National Institutes of Health USA (NIH; 1R01NS109498) and by the Federal Ministry of Education and Research We thank Susanna Glaser and Emina Deumic for skillful assistance in tissue culturing The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The author(s) declared that they were an editorial board member of Frontiers This had no impact on the peer review process and the final decision All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Biophysically realistic neuron models for simulation of cortical stimulation Simulation of transcranial magnetic stimulation in head model with morphologically-realistic cortical neurons Metaplasticity: the plasticity of synaptic plasticity Crossref Full Text | Google Scholar doi: 10.1146/annurev-cellbio-100913-013053 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Deaf estimates there are around 880,000 New Zealanders affected by hearing loss Around 4,600 turi/deaf people use sign language as their primary means of communication including parents and whānau of the deaf community interview-based documentary series that explores the world of turi/deaf Māori in Aotearoa 15 interviewees from across Ngāti Turi discuss their experiences BEING TURI premieres on MĀORI+ at 12.00PM on 3 October 2024 Aotearoa’s only known turi director says working on the series was an incredibly inspiring journey “Our aim was to create a series that not only entertains but educates and raises awareness about the unique experiences of the Māori deaf community,” says Jared Flitcroft “BEING TURI highlights the rich and vibrant culture of the Māori deaf community in a way that is both authentic and captivating.” says he feels an immense respect for the hardships that many of the interviewees have endured “I feel honoured and humbled to have been allowed to create such an important series that opens the door to a community very few in Aotearoa New Zealand know anything about,” says Corey “It was awe-inspiring to see the crew grow and learn more about this rich and diverse community and I look forward to viewers across Aotearoa New Zealand having that same experience.” we have woven together all three of our official languages: NZSL te reo Māori and English,” says Corey Le Vaillant Ninety percent of the series also includes NZ Sign Language Whakaata Māori commissioner Jay Wanakore provided further support BEING TURI was filmed in the following locations: EPISODE 1: Mātauranga (Education) – Tāngata Turi discuss their experiences within Aotearoa’s education system and the establishment and development of Rūaumoko Marae EPISODE 2: Ngā Kaiwhakawhiti Reo (Interpreters) – Waitangi Day is the backdrop to a discussion about the urgent need for trilingual interpreters: those who can translate between NZSL EPISODE 3: Wāhine - Wāhine Turi Māori discuss their lives in connection to Ngāti Turi and te ao Māori more broadly EPISODE 4: Ngā Āraitanga (Barriers) – Societal barriers affect tāngata turi every day This episode asks how these barriers have arisen EPISODE 5: Ngā Haerenga (Journeys) – A look at the younger generations of tāngata turi the choices they are making within and for their community with particular focus on intersectionality and the experience of rainbow youth Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors Our goal is to provide our students with a quality out of class experience that supports and amplifies the teaching and learning process which is the heart of our University Students may choose from a wide range of opportunities which are designed to help them develop their leadership abilities and to have an enjoyable collegiate experience with great memories that will never end Professor David Turi has an extensive background in the entertainment and media industry with over 20 years experience As the controller for two high profile international talent agencies David has had the opportunity to work throughout the world Italy attending a Leadership program for Franciscan based organizations and continues his work by serving as a permanent member of the Franciscan Center for Mission Integration The purpose of this Center is to educate secular faculty administrators and executives in the Franciscan Tradition In addition to permanent membership in the Franciscan Center David sits on the Institutional Assessment Council at Felician College The Institutional Assessment Council provides guidance and support for the ongoing assessment of academic non-academic and administrative units of the College David completed his studies at Seton Hall University and has his PhD in Higher Education Leadership His interest in research is in the area of student engagement and student development David is the Associate Dean of Undergraduate Business Programs at Felician College This website uses cookies so that we can provide you with the best user experience possible Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings we will not be able to save your preferences This means that every time you visit this website you will need to enable or disable cookies again Kindergarteners from across the municipality welcomed the new season our very own Murumoor visited Türi to greet the children They delighted the children with their songs and filled all of us with a wonderful springtime spirit," said Triin Pärna head of the spring capital organizing committee A large number of Türi residents came out to welcome spring "It is characteristic of Türi that regardless of the weather we were very lucky that spring decided to arrive in the middle of the day allowing us to invite all the kindergarten children from Türi municipality," Pärna said In the evening a celebration with music and food was held for residents of the central Estonian town Pärna highlighted some key events from the cultural program planned for the spring We will dedicate some events to the Year of the Book the traditional Türi Flower Fair will take place," she said "Spring lives in the heart of every Türi resident all year round this feeling grows especially strong," one local rejoiced Follow ERR News on Facebook and Twitter and never miss an update! 0)" class="article-poll-disclaimer" ng-bind="totalVotes + ' hääletajat'"> {{option.votes}} {{selectedLanguage.poll.votes}}/ Iga kasutaja võib hääletada {{poll.optionLimit}} vastusevariandi poolt 1 News Portal in J&K in term of serious News The rugged Newsportal is with a substantial difference to read and presence to feel This newsportal has a vision to deliver the real side of truth to the public Cross Town News has a mission to deliver high quality news across the nation within fraction of time the long-running Italian restaurant with a famous wine list has closed down quietly a year after the retirement of founders Giuseppe and Pamela Turi The Turis launched the restaurant in Putney in 1990 transferring it successfully to Pimlico in 2015 Their personal touch – and Giuseppe’s encyclopaedic knowing of Italian wines –  combined to establish a loyal fan club of regulars one of whom told the 2024 Harden’s survey: “If Italian wine is your thing Restaurateur Dominic Ford and David Gleave were announced as new owners when the Turis retired in August last year but it seems the restaurant closed for business in August this year saying this week that he had resigned from the business in January Already Registered? Login NEWSPyramid restaurant drawing crowds to Stockport NEWSLast orders at Lyle's as James Lowe calls time NEWSHARDEN'S INSIDER: the future of 'fair' coffee Former Fire Department of the City of New York (FDNY) Firefighter Albert Turi Jr reflects on being a first responder during the September 11th attacks The retired firefighter recalls responding to only two incidents at the Twin Towers since his first year as a member of the FDNY in 1968; the 1993 World Trade Center Bombings and the 9/11 attacks Turi shares the moment he learned about the first aircraft crashing into the North Tower of the World Trade Center and being only 1,000 feet from the South Tower when the second aircraft hit that building Turi characterizes the 9/11 attacks as the “perfect storm.” Two of the world’s most prominent buildings were engulfed in flames at a volume that the best firefighters in the world had never seen or trained for and sprinkler systems were all compromised Turi recalls leading people out of the collapse zone after the South Tower collapsed to the ground He was one of two people to recover Ganci’s body at Ground Zero days after the attacks Turi’s longtime friend and brother in the department since 1968 remains the only chief of the FDNY to die in the line of duty Tunnel to Towers Foundation is a 501(c)(3) nonprofit registered in the US under EIN: 02-0554654 The donation platform that supports this campaign is currently undergoing maintenance. Please try again later, or make a general donation to the Tunnel to Towers Foundation now Learn how to describe the purpose of the image (opens in a new tab) Leave empty if the image is purely decorative Melissa (Mike) Matlock,  Tim (Janice); grandchildren Pat; and many other loving family & friends Linda was a longtime pharmacy technician in the Roseville area February 2 at MUELLER-BIES FUNERAL HOME-ROSEVILLE This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Post Courier THE alarming statistics across the police barracks in NCD and Central Province of gender-based violence and polygamous relationships has acting Assistant Commissioner of Police Benjamin Turi admonishing his police officers to “cut it out” as it is affecting the performance of police officers and their families are suffering ACP Turi said: “You will lose your home if you continue to allow your family to suffer while you go about your other business “Women are coming to me saying that their husbands are having extra-marital affairs “I have often advised them to report to the Family Sexual Violence Unit (FSVU) to be dealt with GBV is another issue affecting families inside the police barracks When police officers have extra-marital affairs they can become violent towards their wives and children He has put his full support behind the FSVU and urged them to “persecute any officer who is involved in these crimes” ACP Turi said he had told FSVU that “any reports from the barracks must be dealt with and I will ensure every single policeman or woman is dealt with and does not interfere in your investigations” Get the latest news delivered straight to your inbox How can genetic testing and DNA typing help solve crimes And what are the issues with using these techniques first in Canada and later reading for a degree in Archaeology and Anthropology at the University of Cambridge she then went to study at the world-famous Genetics Department at the University of Leicester on a scholarship She went on to study for a PhD in Molecular Genetics on genetic genealogy Her award-winning PhD examined the relationship between the Y chromosome and British surnames combining forensic DNA techniques with history and genealogy Professor Sir Alec Jeffreys,who invented DNA fingerprinting Named as one of the world’s ‘rockstar genealogists’ her work since has covered not only family history but the use of genetic genealogy in forensics and historical cases She is working on a number of forensic/ancient cold cases including King Richard III She has been conducting genetic genealogical research for over 20 years For some projects she is under a confidentiality agreement and unable to speak about them but is happy to talk about cases for which she is not under a CDA Professor Turi King is currently featuring in BBC 2/Minnow Films DNA Family Secrets Turi is also Professor of Public Engagement and Genetics at the University of Leicester and carries out a great deal of media and television work She is an Honorary Fellow of the British Science Association a Fellow of the Society of Antiquaries of London an Affiliate Member of the Chartered Society of Forensic Sciences and a Member of the International Society of Forensic Geneticists Product links on this page may be affiliate links which means it won't cost you any extra but we may earn a small commission if you decide to purchase through the link The Royal Institution is an independent charity dedicated to connecting people to the world of science Contact us What we do About us    Jobs Make your next event one to remember at our unique central London venue Find out more Support us in our charitable mission to create opportunities for the public and scientists to explore science together Donate online Join the Ri More ways to support Find us Museum Licensing Shop The Royal Institution of Great Britain was granted a royal charter in 1800 and is registered as a charity in England and Wales (227938) The CHRISTMAS LECTURES® are a registered trademark