Hisashi Fujioka always had a love for biology and the natural world around him That passion drew him to earn his PhD at Nagoya University before forging a 30-year research career in different aspects of science at Case Western Reserve the Case Western Reserve University community is mourning the passing of Fujioka renowned for his brilliant mind and collaborative spirit,” said Sudha Chakrapani Hord Professor and Chair of the Department of Pharmacology “His contributions were instrumental in groundbreaking work on neurodegenerative diseases and malaria research After arriving at CWRU in 1994, Fujioka held a variety of roles at the School of Medicine, most recently sharing his expertise as manager of standard electron microscopy (EM) services for the CryoEM Core He previously spent time in both the Department of Pharmacology and the Institute of Pathology A passionate researcher in the School of Medicine malaria community for many years Fujioka came to Case Western Reserve to serve as faculty in renowned malaria researcher Masamichi Aikawa’s lab he contributed to more than 100 published papers and he was a consummate electron microscopist,” said Clifford Harding Kahn Distinguished University Professor and Chair of the Department of Pathology “I first got to know Hisashi in the early 1990s after I had discontinued electron microscopy as a technology in my lab to focus on other technologies Hisashi helped us perform immunoelectron microscopy in projects on exosomes and bacterial vesicles.” Fujioka’s family will receive friends Wednesday, Jan. 29, at 5 p.m., at The Dicicco & Sons Funeral Home, located at 5975 Mayfield Rd. in Mayfield Heights. A service will follow at 5:30 pm. In lieu of flowers, the family has suggested donations to the Case Western Reserve University School of Medicine Masamichi Aikawa, M.D. Memorial Lecture Fund.  Read Fujiokas full obituary. Students who would like support are encouraged to contact University Health and Counseling Services at 216.368.5872 This line is staffed by a counselor 24 hours a day Faculty and staff can access counseling at any time by calling AllOne Health (formerly IMPACT Solutions) at 1.800.227.6007 Interested in participating in a research study Looking for an upcoming event in your department Subscribe to The Daily Items that appear in the Community Postings section are submitted by visitors Posts are reviewed to ensure they are appropriate for our audience but typically are not edited by University Marketing and Communications Case Western Reserve University is committed to academic freedom and promoting diversity of thought The views of those who speak on our campus do not necessarily reflect the views of the university administration or any other segment of the university community The call that Tad Fujioka was overdue could not have come at a worse time Sitka and the outer coast of Southeast were being lashed by a windstorm with some gusts in excess of 50 miles per hour Fire Chief Craig Warren says Air Station Sitka launched a helicopter nevertheless equipped with Forward-Looking-Infrared (FLIR) to search an area about ten miles north of Sitka in Nakwasina Sound “The Coast Guard did fly the night of the report and kind of looked around the area,” said Warren they couldn’t see much through the FLIR we deployed teams out of the Fire Department before 8:00 a.m. The first team was on the ground there about 8:30 dropped in by the Coast Guard.” Fujioka was believed to be returning to an area where he had shot a deer on Monday in much better weather Warren says the department organized 25 members into three teams for the ground search The Coast Guard flew two of the teams to a high point above the area where Fujioka was believed to be hunting His body was found by a ground team at about 11:30 in the morning Wounds indicated that Fujioka had died from a bear mauling The shock reverberated quickly around Sitka Norm Pillen is the President of Seafood Producers Cooperative he worked in Sitka’s municipal engineering department and an attention to detail in fisheries allocation issues that made him a powerful advocate at Alaska Board of Fisheries meetings The next is scheduled for this January in Ketchikan Pillen says Fujioka’s absence will be felt and had tremendous ability for recall and digging into things and pulling out information that he needed,” said Pillen It’s going to be a huge hit for the industry to not have him involved.”  Fujioka’s analytical mind and understanding of bear behavior led him to suggest something small-scale and possibly effective “What if you looked at it from the other way and we had some booby trapped garbage cans out there maybe it would only take one or two bad experiences for a bear to associate that big black thing with an unfavorable experience,” Fujioka told fellow committee members. The bear that likely killed Fujioka was a brown bear sow with two cubs She was seen by the Coast Guard helicopter in the area near where Fujioka’s remains were found but ground searchers did not encounter her Fish & Game biologist Steve Bethune accompanied searchers on Wednesday He characterizes the incident as a defensive attack – rather than predatory – and the sow had almost certainly claimed the deer carcass and was defending her food supply Bethune said some efforts were made Wednesday afternoon to locate the bear on the ground His death remains under investigation by Alaska Wildlife Troopers KCAW Prize Drawings: click on the links for rules and winner info Try a different filter or a new search keyword Patrick Shiroishi is a Japanese-American multi-instrumentalist & composer based in Los Angeles Streaming and Download help Redeem code supported by 18 fans who also own “Left up on the Tree” It's the first album to make me experience emotions I didn't know I had before this I never cared about Alzheimer's supported by 17 fans who also own “Left up on the Tree” Serene sounds and drifting textures makes for a great live album Wild and free-spirited improvisational jazz from this Chicago ensemble The Wellington free music outfit were true outliers supported by 16 fans who also own “Left up on the Tree” Bandcamp Daily  your guide to the world of Bandcamp Wider Reeding: Clarinets and Saxophones Put to Unusual Uses Marion Brown’s “Why Not” Is a Sweet Glimpse of Midcentury Free Jazz Backxwash joins the show to discuss her recent release Asako Fujioka is an independent consultant and producer with a focus on strengthening the creative documentary genre in Asia She has worked with the Yamagata International Documentary Film Festival since 1993 as Coordinator and now Vice-chair on the Board of Directors She advised and served on the selection committees of the Asian Network of Documentary (AND) at the Busan International Film Festival and has been on international juries of Berlin (Forum) and many other festivals.  As head of Documentary Dream Center she launched the filmmaker residency Yamagata Documentary Dojo in 2018 from where many international award-winning films have emerged She helps Japanese films liaison internationally and aims to foster an international exchange for documentaries She is the producer of Nude at Heart (2021 dir: Okutani Yoichiro) and handles the international distribution of Tokyo Uber Blues (2023 dir: Aoyagi Taku) and other documentaries.  IDA: Please tell us a little about yourself and your profession or passion Growing up in New York and Duesseldorf in a Japanese family I developed a longing for the unknown Japan and Asia where I imagined all my adolescent anxieties of identity would instantly be resolved the economic bubble opened opportunities for the expansion of art-house cinemas from around the world was introduced to the Japanese public My first job after college was at Cine Saison one of the earliest commercial distributors of the art-house films We were working with the early works of Hou Hsiao Hsien We also released Michael Moore’s Roger and Me and Christine Choy’s Who Killed Vincent Chin? in our cinemas.  IDA: When did you first start working in the documentary field When I became disillusioned with the commercialized marketing and packaging of film as a product rather than film as art I started working for a documentary photographer I discovered the wonderful world of creative documentary an emerging international event far from Tokyo in the mountains of northern Japan This became the “home” I’d been searching for.     IDA: You have worked with the Yamagata International Documentary Film Festival (YIDFF) since the early 1990’s Tell us a little about the growth of YIDFF and how it evolved into being one of the most exciting and impactful gatherings in the non-fiction field Yamagata also became known as a comfortable place for socializing and meeting people and locals were welcomed equally at the festival hangout (and became equally drunk) every night a place where people gathered for the sake of their love for cinema and not because of work obligations or press coverage It was a place for non-Japanese film professionals to discover Japan outside of its usual corporate or formal image Encounters here have given birth to new films The next edition is October 2025 and our call for film entries is now open.    IDA: Tell us the origin story of Documentary Dream Center and your current role in the organization.  Documentary Dream Center came out from my concern for the sense of solitude and pressure on contemporary documentary filmmakers who researched and struggled to do everything by themselves an emerging wave of independent documentary filmmakers were bringing out stories from their own cultures and perspectives – issues and emotions that had not been accessible to outsiders before But in working with the AND Fund at Busan Film Festival (Korea) I noticed that many promising Asian film projects that we awarded grants to seemed to be finishing prematurely They had good subjects and unique perspectives with lots of footage from years of filming but the completed film seemed rushed and simply slapped together The films were missing important background information that insiders would take for granted but outsiders wouldn’t understand It was like the filmmaker got tired at the end of a long journey and stopped caring I hosted a series of workshops in remote places in Japan where filmmakers had to communicate across cultures and work together Working with each other and with mentors who were practicing filmmakers gave each other new perspectives and enthusiasm towards new approaches and editing styles.  This evolved into the 4-week residency program Yamagata Documentary Dojo which is now in its seventh edition offering Asian filmmakers working on new works a long-term stay to deepen their thinking through international exchange The process of editing and structuring the footage after shooting is decisive in determining the direction of a documentary film This program provides the time and place to enhance this stage of filmmaking.  IDA: Any advice for young producers who are just joining the field and each film-life should find different paths unique to each own and it also means you can never stop trying.   Are you working on anything you can share with us My upcoming challenge is to theatrically release and distribute across Japan some of the award-winning documentaries that came out of past Dojo programs They include Scala (2022 / Ananta Thitanat Taiwan/Philippines), Monisme (2023 / Rial Rizaldi Many of our Japanese alumni have already successfully made their domestic theatrical runs Would you like to receive event invitations and other updates from the International Documentary Association virtual on Zoom or in-person at IDA Office in Los Angeles © 2024 International Documentary Association Privacy Policy Police confirmed Friday that remains found about 200 yards off Oahu’s North Shore were of Joseph “Joey” Fujioka one of two teenagers who went missing last weekend and 17-year-old Samantha Chun were the subject of a multiagency four-day search after they didn’t return home on the night of Jan 17 following an evening on the North Shore The ocean search for the two missing Mililani teenagers was suspended at sunset Tuesday The remains were discovered in the water off Ke Iki Beach on Saturday afternoon the HPD Scientific Investigation Section Forensic Biology Unit confirmed that the profile obtained from the recovered tissues matched the DNA profile of Joseph Fujioka HPD has notified his family,” the Honolulu Police Department said this morning in a news release “Our family continues to hold out hope that Sammy will be found and brought home safely We are deeply grateful for the support and prayers from our community during this incredibly difficult time and we ask everyone to remain vigilant and share any information that could help bring her back to us we grieve deeply for Joey’s family and the unimaginable loss they are enduring and we share in their pain during this tragic time We trust in the ongoing efforts of law enforcement and the kindness of those around us and our families in your thoughts and hearts.” The teens were last seen purchasing items at a Mililani convenience store around 9:54 p.m The water conditions on the North Shore from Jan Coast Guard was notified about the missing teens around 11 a.m 18 after Fujioka’s mother found his and Chun’s belongings on the beach Joseph left his home to pick up his girlfriend from her home in Mililani,” Thoemmes said they went to the Aloha Gas station on Kipapa Drive and then they arrived at the beach around 10:30 p.m and the vehicle was later found locked and secured.” Fujioka and Chun set up a blanket on the beach near where they parked and their belongings were recovered from the area Based on the location of Fujioka’s phone his family determined that the phone ran out of battery power at 11:06 p.m. with the last recorded location at the beach From Tubes To Turns, Jai Glindeman's Surfing is a Treat to Behold Gerry Lopez Goes Deep With Justin Jay On The Plug Podcast Spot Guide: Rincon Queen, of the Coast NewsAll NewsEventsBig Wave NewsWorld Surf LeagueEnvironmentalIndustryWave PoolsPosts List Winners of SURFER's Emerging Brands Grant Announced New Water Quality Regulations in New York Won’t Necessarily Make Water Any Cleaner After an extensive, multi-agency search on land, air, and sea for two missing teens on Oahu – Samantha Chun (17) and Joseph “Joey” Fujioka (18) – officials called off the hunt on Tuesday. However, the same day the search was called off, human remains were found offshore from Ke Iki Beach, the last place the teens were known to be on the evening of Friday, January 17th. Now, officials have confirmed that the human remains matched the DNA of Fujioka. In a press release, the Honolulu Police Department said: “On January 23, 2025, at approximately 8:00 p.m., the HPD Scientific Investigation Section Forensic Biology Unit confirmed that the profile obtained from the recovered tissues matched the DNA profile of Joseph Fujioka. HPD has notified his family.” Chun and Fujioka, a couple from Mililani, drove to the North Shore on January 17th. They arrived at Ke Iki Beach around 10:30pm, locked their car, and went down to the sand. After they never returned home, their belongings on the beach and the car were found undisturbed where they left them. Following the confirmation of Fujioka’s DNA in the human remains, Chun’s family issued this statement: “Our family continues to hold out hope that Sammy will be found and brought home safely. We are deeply grateful for the support and prayers from our community during this incredibly difficult time. Sammy is a beloved daughter, sister, and friend, and we ask everyone to remain vigilant and share any information that could help bring her back to us. “At the same time, we grieve deeply for Joey’s family and the unimaginable loss they are enduring. Our hearts are with them, and we share in their pain during this tragic time. We trust in the ongoing efforts of law enforcement and the kindness of those around us. Please continue to keep Sammy, Joey, and our families in your thoughts and hearts.” Joey’s friend, who spoke to local news, called him the “nicest guy.” The friend continued: “Joey’s just like…he will do anything. If you have a problem, he will drop everything to listen to you, do anything for you.” © 2025 BVM Sports. Best Version Media, LLC. concluding their collegiate careers as three-time all-conference selections Tuifao earned a spot on the All-PacWest First Team as a catcher leading her team with a .359 batting average completed her senior season with a .353 average and 32 runs This recognition emphasizes their significant contributions to the Silverswords' program While both players achieved impressive individual milestones the overarching narrative of Chaminade's performance within the conference raises questions about the team's competitive consistency in a rapidly evolving league Following the departure of these key seniors Chaminade will need to cultivate new talent to sustain or improve upon their current standing in the PacWest Future recruitment efforts will be critical as the program seeks to replace its all-time leading hitters Fujioka and Tuifao’s achievements not only highlight their talent but also underscore the importance of building a strong team foundation as Chaminade looks to the future in the competitive landscape of collegiate softball The summary of the linked article was generated with the assistance of artificial intelligence technology from OpenAI We use cookies to ensure that we give you the best experience on our website If you continue to use this site we will assume that you are happy with it OK Privacy policy The remains of a 50-year-old man, suspected to have been fatally mauled in a bear attack were recovered from a remote region in Alaska Tad Fujioka, 50, was reported overdue from a deer hunting trip in the Sitka area of Alaska, about 600 miles southeast of Anchorage, Tuesday evening, Alaska’s Department of Public Safety said in a news dispatch Wednesday He was hunting alone in the remote area of Nakwasina Sound department spokesperson Timothy DeSpain told USA TODAY Thursday multiple agencies including the Alaska Wildlife Troopers and the United States Coast Guard "conducted land-based searches utilizing three search teams in the remote wooded area" where Fujioka’s boat had been located Authorities found his deer kill site and his remains around 11:30 a.m "Investigation revealed he was the likely victim of a fatal bear mauling," the news release said adding the man's next of kin has been notified DeSpain said troopers and Alaska Department of Fish and Game "searched for the bears until daylight constraints ended the search" but were unable to locate them "The bears had consumed the deer and left the immediate area which is remote and difficult to access," he said adding there were multiple brown bears that had been feeding on the deer carcass Investigation: Suspect arrested in Montana 'horrific' homicide initially reported as possible bear attack Alaska is home to three types of bears - black, brown, and polar - according to Alaska Fish and Game. The agency has listed detailed tips on how to remain safe while hunting in bear country Consider carrying a second deterrent such as bear spray and have it accessible.Stay calm: Face the bear and talk to it calmly.Look big: Slowly raise your arms overhead so you appear larger stand side-by-side to make yourselves look larger.Don't run: Running may elicit a chase response.Stay alertAvoid leaving a blood trail back to your campImmediately field dress a game animal after the kill and avoid opening the gut cavity until after you have salvaged all other edible meat if possible to help limit odors.Saman Shafiq is a trending news reporter for USA TODAY Reach her at sshafiq@gannett.com and follow her on X and Instagram @saman_shafiq7 Get the best experience and stay connected to your community with our Spectrum News app. Learn More The Honolulu Police Department confirmed remains found by divers about 200 yards offshore from Ke Iki Beach match the DNA profile of Joseph Fujioka one of two teens who went missing last week on Oahu’s North Shore.  were reported missing by the boy’s mother after he did not return home last Friday family members found their belongings at Ke Iki Beach waves were in the 40-foot face range.  and Hawaii Wing Civil Air Patrol all working together.  officials said at a news conference that the search would be suspended Fire Captain Jaimie Song said human remains were found in the area but they did not know at the time if the remains were related to the search effort the HPD Scientific Investigation Section Forensic Biology Unit confirmed the profile from the recovered tissues matched the DNA profile of Joseph Fujioka Michelle Broder Van Dyke covers the Hawaiian Islands for Spectrum News Hawaii. Email her at michelle.brodervandyke@charter.com "We don’t know what happened that night The waves were huge," the families of Samantha Chun and Joey Fujioka said By Victoria Budiono Officials confirmed Tuesday that human remains were found about 200 yards off Ke Iki Beach on the North Shore but have not yet identified them or determined if they are linked to the recent disappearance of two teenagers A multiagency search for two missing Mililani teens 17-year-old Samantha Chun and 18-year-old Joseph “Joey” Fujioka The teens were reported missing after failing to return home Friday night following an evening on the North Shore Jaimie Song said the Honolulu Fire Department discovered remains in the water off Ke Iki Beach on Saturday afternoon the Honolulu Medical Examiner confirmed the remains were human officials have not yet determined whether they belong to a single body Song said the Chun and Fujioka families have been notified about the recent discovery though the identity of the remains has not yet been confirmed involving three air assets from the HFD and Coast Guard three ocean assets from Honolulu Fire and Ocean Safety and one fire crew actively searching the shoreline Jesse King said the water conditions from Friday night into Saturday morning were large and dangerous Michelle Rice said the agencies decided to suspend the search at sunset Tuesday “The decision to suspend the case is always very complex and difficult,” Rice said “We have a lot of discussion with our partner agencies to make sure that we are making the best decisions that we can as a group and collectively and just given the situation surrounding the case as well as our search efforts to this point we’ve come to that very difficult decision to suspend the case tonight at sunset.” Deena Thoemmes confirmed that HPD is continuing its investigation into the missing persons case they went to the Aloha Gas station on Kipapa Drive and then they arrived at the beach around 10:30 p.m and their belongings — including car keys clothing and other personal items — were recovered from the area his family determined that the phone ran out of battery at 11:06 p.m. and the car is being processed as part of the ongoing investigation Detectives are continuing to interview witnesses review surveillance footage and examine evidence foul play has not been ruled out as the investigation continues ‘He Was Such a Legend’: A Decade After His Death, Shawn “Barney” Barron’s Spirit Shines in Colorful Air Show Hawaiian Big Wave Icon Clyde Aikau Passes Away at 75 after they went missing on a North Shore beach during 30-to-40-foot waves two teens went on a date on Oahu’s North Shore – but never came home were reported missing following their disappearance on Friday night their belongings found undisturbed on the sand A multiple agency search for the teens ensued And human remains – yet to be identified – were found some 200 yards offshore in the same waters where the teens were last known to have been Deena Thoemmes outlined the series of events leading up to the disappearance: they went to Aloha Gas on Kipapa Drive and then they arrived at Ke Iki Beach at about 10:30 p.m and the vehicle was later found locked and secured “They set up a blanket on the beach nearby where they parked his family was able to determine that his phone ran out of battery at 11:06 p.m the families of both issued a joint statement on Tuesday: “Both families would like to say thank you to all the rescue personnel who have searched tirelessly and selflessly for our children All organizations have been amazing during this impossible time; Police as well as the volunteers who have searched the surrounding areas around neighborhoods and into the mountains – all who are working to help bring our children home Thank you to those who have printed fliers and spread the search throughout social media Thank you also to Sunset Beach Christian Church and the surrounding neighbors on the North Shore thank you for your outpouring of love and concern Thank you for being persistent in your search If anyone saw them that night or has any information that might help us find them We don’t know for sure that they went into the water The waves were huge and both kids were born and raised in Hawaii and know and love the ocean.” Monday (May 5) for more than 3,200 seats on city councils The book was produced by four classes of seventh graders supervised by English teacher Mandy Davis King County Sheriff’s Deputies found a deceased person in a car parked in the Mom’s Deli parking lot the afternoon… most recently earning her Master of Science in Athletic Training from Illinois State University in 2011 After developing in an interest in Athletic Training Yuri pursued her Bachelor of Science from Oregon State University Yuri's professional interests include manual therapies and she has completed the Graston Technique Module 1 Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here Ocean Safety continued search for missing teens Joey Fujioka and Samantha Chun on Sunday with their belongings found on Ke Iki Beach near Shark’s Cove Family and friends of both teens have kept vigil over the beach as well as assisted with the first responders’ efforts to look for them By Jamm Aquino Hawaii Photos Privacy Policy | About Our Ads The Coast Guard suspended its search at 6:15 p.m Tuesday for two teens who went missing off the North Shore of Oʻahu who were last seen on Ke Iki Beach near Sharks Cove late Friday night Coast Guard and partner agency crews searched 2,321 square nautical miles for over 54 combined hours “Considering all pertinent factors and available information we made the difficult decision to suspend our search efforts,” said Lt “We are grateful to our agency partners for their teamwork and extend our deepest condolences to Samantha and Joseph’s families during this difficult time.” Coast Guard Sector Honolulu watchstanders received notification at 11 a.m Saturday from Honolulu Fire Department personnel that Fujioka’s mother had reported the pair missing at 10:45 a.m Watchstanders directed the launch of a Coast Guard Air Station Barbers Point MH-65 Dolphin helicopter crew to aid in the search Involved in the search were the following assets: The search for two missing teens off Oahu’s North Shore continued on Monday without success Honolulu Ocean Safety said this evening it will resume the search with its partners today The surf is expected to be smaller than in previous days 18 – were last seen Friday night at a Mililani convenience store but family later found their personal belongings Saturday morning at Ke Iki Beach A search has been ongoing since Saturday morning by multiple agencies lifeguards on an ATV and mobile lieutenants in the search today which responded to a 911 call Saturday at about 10:45 a.m. said the department coordinated a search by land Sunday and Monday at sunset due to darkness but are scheduled to resume at first light today HFD Battalion Chief Robert Thurston told the Honolulu Star-Advertiser on Sunday that its policy is to search for three full days unless the department receives new information or there’s a reason for the fire chief to extend the search That determination will be made on Tuesday which would be considered the third full day of searching Honolulu CrimeStoppers also has issued a bulletin with photos and descriptions of the missing teens 3-inches tall and about 125 pounds with brown hair and brown eyes 10-inches tall and about 180 pounds with brown hair and brown eyes Anyone with information is asked to call CrimeStoppers at 808-955-8300. Anonymous web tips can submitted to honolulucrimestoppers.org or via the P3 Tips app “Kamen Rider” (Masked Rider) has been a monumental part of the tokusatsu genre of television programs please disable the ad blocking feature and reload the page This website uses cookies to collect information about your visit for purposes such as showing you personalized ads and content By clicking “Accept all,” you will allow the use of these cookies Users accessing this site from EEA countries and UK are unable to view this site without your consent By Yoshitaka Tsujimoto / Yomiuri Shimbun Staff Writer And it all began with actor Hiroshi Fujioka Fujioka excited children across Japan and laid the groundwork for a series that has lasted more than half a century He has also starred in a Hollywood movie and shown a humorous side in TV commercials and variety shows he has visited more than 100 countries and has been involved in relief activities in refugee camps and other places and the physical strength he maintains at age 78 have supported a wide range of activities Fujioka was born into a family with a longstanding tradition of practicing martial arts in Ehime Prefecture he ventured to Tokyo alone after graduating from high school he was discovered while working part-time and invited to join movie giant Shochiku Co Speaking in his home prefecture’s Iyo dialect and having a mild-mannered personality gave him a massive inferiority complex but he still made his movie debut in 1965 ahead of his rivals he found that the focus on adolescence in Shochiku’s films didn’t suit him He secretly auditioned for roles outside the company “[When I heard that they were looking for] someone who was physically able to do action scenes do martial arts and could ride a motorcycle They told me to wear a mask that looked like a skull I was shocked to hear that my face wouldn’t be shown a still photographer and a leading specialist in tokusatsu hero photography remembers the first time he met the lead actor on the filming set I thought he was quite unique,” Oshima said so he looked good whether he was kicking or riding a motorcycle,” Oshima added Fujioka also performed as a suit actor in costume “I felt pressure to go to the set every day.” The masks restricted his field of vision and the costume made it difficult for him to move he fell while filming on his Cyclone motorcycle He suffered a complex fracture of his left femur and was unable to act The crew bought time by having non-Fujioka characters such as “Kamen Rider No Immediately after returning to work six months later Fujioka found himself called on to drive the Cyclone over slippery volcanic ash during a shoot on the island of Sakurajima in Kagoshima Prefecture With iron pins in his leg to support his bones he trembled for the first time in his life But the trusting eyes of the staff watching him made him determined to do it But even now he has no memory of the moment thanks in part to sequences in which the two Kamen Riders fought together and mothers became fascinated with Fujioka “He was like how South Korean idols are now We had trouble keeping the screaming moms off the set,” Oshima said nostalgically Fujioka appeared in the movie “Nihon Chinbotsu” (Japan sinks) as well as NHK historical dramas and the TV Asahi detective drama “Tokuso Saizensen” (Special investigation frontline) he went to the United States and auditioned as his own for the Hollywood movie “Ghost Warrior.” He demonstrated the art of sword fighting with a real sword and won the lead role financial troubles and poor health prevented him from performing for nearly 10 years he received an offer to appear in TV commercials for the Sega Saturn video game console He would play the mascot character “Segata Sanshiro,” a parody of the judo fighter protagonist of a classic novel “Sugata Sanshiro.” “The only hero with the overwhelming power to get to the bottom of things was Kamen Rider who follows the bushido way of life,” said Koji Ando ran on ice barefoot and broke a stack of roof tiles with his head In a scene where he repeatedly strikes a giant game controller and in 2002 he began appearing in “Fujioka Hiroshi Tankentai” (Hiroshi Fujioka’s exploration party) he would spend a month or more in a location such as the Amazon or the Guyana highlands His philanthropic activities began when he started visiting children’s homes while he was starring in Kamen Rider He has traveled to disaster-stricken areas in Japan famine- and epidemic-ravaged Sudan and Ghana and other danger zones to deliver relief supplies to refugee camps and hospitals he continued to regret that he did not move his base to Hollywood after starring in “Ghost Warrior.” His four children who have also entered the entertainment industry seem to be aware of their father’s feelings “They often tell me they want to make a movie in Hollywood with me as the lead,” he said It has served as the foundation for many skills he has learned martial arts using swords; kodachi goshindo under various masters while training to be an actor He also excels in horsemanship as well as spear and star throwing “I feel his natural strength in the way he moves His movements when slashing a real sword are graceful and the way he throws shuriken stars is also beautiful,” he said Fujioka’s martial arts experience has served him well in his many appearances in NHK historical dramas where he has played samurai and warlords in such dramas as “Katsu Kaishu,” “Kasuga no Tsubone” and “Dosuru Ieyasu” (What will you do He often gives volunteer performances in Japan and abroad slicing rolls of straw with a stroke of a real sword I don’t feel out of the ordinary at all [when I’m using it],” Fujioka said Our weekly ePaper presents the most noteworthy recent topics in an exciting © 2025 The Japan News - by The Yomiuri Shimbun DUBAI: Chihiro Fujioka is a Japanese video game designer and composer who has worked at Xtalsoft He is primarily known for directing ‘Super Mario RPG’ as well as his involvement in several Mario and Luigi games Fujioka shared his inspiration for video games “I was first exposed to computers in the early 1980s “My favorite game of all time is ‘PaRappa the Rapper’ on the original PlayStation but it was just so fun and I played it quite a lot,” he added About the establishment of his career as a video game composer Fujioka said he first started composing music when he was in high school as a hobby and began working in music professionally in the mid-1980s “The concepts behind my compositions change from time to time but all of them have one thing in common: to create something new that fits the atmosphere of the game,” he said “The first game I ever made was a PC game called ‘Earthbound’ (different from Nintendo’s ‘Earthbound’) that was released in 1983 and I have very fond memories of it because I made it all by myself from planning and graphics to programming,” he shared adding that the first game he composed music for was the 1986 PC game ‘Babylon’ The producer is known for working on ‘Final Fantasy Legend III,’ which was the first game he worked on after establishing Square’s Osaka Development Department I had discussions with the headquarters to decide what kind of game we should make it was decided that it would be a good idea to create a sequel to the ‘Final Fantasy Legend III’ series that had already been released on Game Boy we were shown many different previous materials and went ahead with the game design of the game.” “We are very happy that the game was successfully completed and is still being loved by many players,” he added Fujioka is known as one of the writers for ‘Final Fantasy Mystic Quest’ Japanese RPGs were not selling well in the United States so Square decided to create an RPG specifically for the US instead of localizing a Japanese RPG as it had done in the past,” he told Arab News Japan “We considered which RPG elements should be minimized and which emphasized we concluded that it would be better to downplay the story and presentation and have more battles We simplified the map and came up with a style of setting up points called the ‘battlefields’ system.” it did so well that the company decided to launch in Japan “Since there was no staff available to help I proceeded with the development of the Japanese version almost entirely on my own I was also in charge of localizing the German and French versions so I got more experience in game localization,” the producer said After establishing relations with Nintendo and AlphaDream Fujioka started working on the ‘Mario & Luigi’ video game series He told Arab News Japan that he wanted to make a Nintendo RPG game where players control Mario and Luigi to differentiate it from ‘Super Mario RPG’ and ‘Paper Mario.’ “In the ‘Mario & Luigi’ series I was primarily programming action-oriented events I had similar programming experience with Square’s ‘Super Mario RPG,’ so I was good at it the unpredictable bugs that occur when there are two playable characters were quite troublesome I remember how fun the technical aspects were such as programming events to link the upper and lower screens” he shared Fujioka said that he feels like the Japanese company cares about games sharing that his favorite project that he worked on was ‘Super Mario RPG’ It was a pleasure to work with such a wonderful and talented team on a world-famous character.” I was programming events with action components I enjoyed programming and was thoroughly engrossed in it because it was a well-designed event system created by very talented programmers and it was a wonderful project that gave us a sense of fulfillment in always creating something new,” he reflected Fujioka has never been to the Middle East before but is very interested in Middle Eastern culture “There are unique melodies and scales that are different from Western scales and the rhythms are complex yet very pleasant I would like to visit the Middle East someday to experience the local music,” he said Please log in and check your service registration status.To cancel your subscription 1) === '|') document.write("&#"+unescape(l[i].substring(1))+";");else document.write(unescape(l[i]));} News sociology) life in civil service is a storied one.   His public service career can be traced back to the 1970s when he worked as a custodian and gardener while pursuing his degree from UC Santa Cruz Fujioka’s career includes work as Los Angeles’s City Administrative Officer the first-ever Chief Executive Officer of the city and his current role as the Chair of the Los Angeles Japanese American National Museum (JANM).     Fujioka came out of retirement to join the Board of Trustees for JANM and eventually was selected to be the Board Chair.  For him the decision to join the JANM Board was an unsurprising one “I strongly feel it’s my generation’s responsibility to not only preserve our history but to retell that history to ensure what happened to my community in 1942 never happens again to any other vulnerable community.  I’m going to be outspoken there’s a tendency to pull back a little bit,” Fujioka says I wouldn’t have gotten to my last two positions in government by being the shy retiring type.” Fujioka succeeds Secretary Norman Mineta as chair of the Japanese American National Museum Mineta’s legacy for the civil liberties of Japanese Americans is incomparable and Fujioka finds inspiration and motivation for his work as Chair of JANM in his succession of Mineta.  The Japanese American National Museum was established in 1992 and is dedicated to preserving the history and culture of Japanese Americans It also serves as a monument of the wrongful persecution of Japanese Americans nationwide The courtyard of the museum was the location where Japanese Americans were forced onto buses and taken away to assembly centers and internment camps across the country Fujioka’s family were forced onto buses at this site.  For Fujioka the site of this horrible act can serve both as a platform for future change and to honor the great accomplishments of his predecessor JANM plans to rename the courtyard as the Norm Mineta Plaza for Democracy.   “I’m hoping that the Japanese American National Museum becomes a place where people convene where people can come together and just talk,” Fujioka says “I also see the National Center for Preservation Democracy a place where people with diverse feelings and on a multitude of issues could come together A place for the community to have a safe place where they can come together.” When Fujioka set out on his collegiate journey his decision to make a move far from the busy streets of Southern California to the forests of UC Santa Cruz was entirely intentional.  Fujioka recounts his youth in LA among street gangs and how his father urged Fujioka to leave town to pursue his education but once he immersed himself in UCSC’s academics and campus he quickly grew to appreciate his future alma mater.  “The first year or two was difficult for me Dennis McElrath; I don’t think he knows to this day what kind of impression he made on me: I took several classes with him Having his passion for public service sparked at UCSC Fujioka hopes to encourage and enlighten students working towards his same path to the impact that their work can create.  “You’re always going to hear me say that I want to shout the benefits of public service that’s what it’s all about: You can make someone else’s life better.” Fujioka credits UC Santa Cruz with giving him a bedrock to launch his career into local government and public service upon his return to Los Angeles Coming from Los Angeles as a self-described average student Fujioka looks back at his time spent learning at UCSC as fundamental to his future at one of the highest levels of public service He ended up graduating earning a degree with honors in sociology he was recognized as one of the top 45 graduates from UCSC “I was an average student when I got accepted there and then I went on to have a great public service career I think because of growing up in the 70s at UC Santa Cruz I truly loved my time and experience at UCSC.” Tributes are flowing in this morning for BABYMETAL guitarist Mikio Fujioka who tragically died at the age of 36 following injuries sustained from a fall The member known to fans as Ko-Gami (aka "The Little God") fell off an observation deck on December 30th and was rushed to hospital however he was unable to recover from his injuries and passed away on January 5th with his wife and two daughters by his side Mikio joined BABYMETAL back in 2013 as part of their Kami Band travelling the world playing with bands like the Red Hot Chili Peppers and Guns N 'Roses as well as picking up appreciation along the way from Lamb of God https://twitter.com/BABYMETAL_JAPAN/status/950716423386509312 Volume 18 - 2024 | https://doi.org/10.3389/fnins.2024.1349366 Although dietary behaviors are affected by neuropsychiatric disorders various environmental conditions can have strong effects as well We found that mice under multiple stresses developed feeding behavior patterns characterized by a deviated bait approach (fixated feeding) All the tested stressors affected dopamine release at the nucleus accumbens (NAcc) shell and dopamine normalization reversed the feeding defects inhibition of dopaminergic activity in the ventral tegmental area that projects into the NAcc shell caused similar feeding pattern aberrations Given that the deviations were not consistently accompanied by changes in the amount consumed or metabolic factors the alterations in feeding behaviors likely reflect perturbations to a critical stress-associated pathway in the mesolimbic dopamine system deviations in feeding behavior patterns that reflect reward system abnormalities can be sensitive biomarkers of psychosocial and physical stress highlight that qualitative changes in feeding behaviors could act as indicators for impaired reward systems associated with stressors and neuropsychiatric conditions we developed a real-time monitoring system to assess feeding behavior patterns as a means to more accurately detect the physiological state of subjects we found that different stress conditions induced alterations to the feeding patterns occurring independently of metabolic alterations exhibited a strong correlation with impairments in the mesolimbic dopamine system they could serve as an ideal biomarker for neuropsychiatric disorders characterized by alterations in reward systems It is thus a good model for elucidating the mechanisms underlying altered feeding behavior patterns in response to stress that is not accompanied by alterations in food intake and body weight Temporally limiting access to palatable diets is a common method to induce binge eating behaviors in rodents (Avena and Bocarsly, 2012) As a stress model for increased food intake and body weight we established an intermittent high-fat diet (HFD) model by randomly assigning 6-week-old inbred mice (C57BL/6J strain) to either an intermittent HFD group or a control group The mice were placed in cages with free access for both standard chow diet and drinking water except for HFD treatment The intermittent HFD group could access HFD (Test Diet 58Y1 and 6.5% fiber) for 2 h every other day whereas ad libitum supply of standard chow (CE2 and 4.65% fiber) was used for the control group mice mice from the experimental and control groups were subjected to real-time monitoring of feeding behaviors and in vivo microdialysis Behavioral analyses were initially performed using male mice followed by validation using female mice as indicated in the individual figure legends Dopamine transporter (DAT)-Cre mice (B6.SJL-Slc6a3tm1.1(cre)Bkmn/J) were obtained from Jackson Laboratories The tyrosine hydroxylase transporter (TH)-Cre mice (B6.FVB(Cg)-Tg(Th-Cre)FI172Gsat/Mmucd) were obtained from MMRRC All animal experiments were performed in accordance with the National Institute of Health Guide for the Care and Use of Laboratory Animals and were approved by the Nagoya University Animal Experiment Committee and the Shiga University of Medical Science Animal Care and Use Committee All methods were carried out in accordance with relevant guidelines and regulations All methods are reported in accordance with ARRIVE guidelines To eliminate any potential artificial effects on the reward system we developed a real-time monitoring system in tandem with regular diet instead of palatable foods and operant conditions to assess feeding behaviors This approach allows us to visualize subtle alterations in ordinary feeding behaviors of animals fed a regular diet The real-time monitoring system consists of a box containing standard chow diet (CE2 CLEA) affixed to the surface of a 60-cm diameter circle originally designed for open field tests Four bait containers (33 × 37 × 22 mm Japan) were affixed at 10-cm intervals along the outer edge of one-half of the circle plate in close proximity to the wall (height The respective diet containers were designed such that the mice needed to physically insert their heads into the container to consume the bait This movement was captured and analyzed with the EthoVision XT 12 (Noldus Information Technology the Netherlands) motion capture imaging system The software was used to monitor approaches to bait containers and the duration of each feeding movement in the arena mice were deprived of a food source for 4 h after which their feeding behavior was observed for 4 h using the real-time monitoring system the residual bait in each container was weighed we defined the distinct aberrant feeding behavior pattern phenotype as “fixated feeding,” which was characterized by an abnormal deviation in food selection mice with spatial fixation approached a specific bait container more frequently than the other containers whereas control mice had no bait preference The amount of dopamine in the NAcc shell was measured by microdialysis The guide cannula was stereotaxically placed into the right side of the mouse NAcc shell (L: +0.42 H: −3.95) a week prior to the measurement Mice were anesthetized via intraperitoneal injection with a mixed anesthetic agent consisting of medetomidine (0.3 mg/kg) Experimental mice were deprived of food for 15 h prior to the start of the assay Dopamine levels were monitored by HPLC-ECD (HTEC-510 Eicom) placements were verified histologically at the ends of each experiment and experimental data were excluded if the membrane portions of the dialysis probes lay outside the NAcc shell region Mice under the three experimental conditions selectively had dopamine administered into the NAcc shell H: −4.25) 1 week prior to assessing feeding behavior Mice were properly anesthetized as described above The dopamine solution was prepared as 3-hydroxytyramine hydrochloride: C8H11NO2-HCl (Tokyo Chemical Industry Japan) diluted in solution buffer [0.5% ascorbic acid (ASA; Iwaki Seiyaku Dopamine administration was performed 5 min prior to feeding behavior analyses by injecting 0.5 μL dopamine solution (200 μg/μl) into the NAcc shell at a flow rate of 0.25 μL/min The injection cannula was maintained in place post-injection for 3 min the same volume of 0.5% ASA/Ringer’s solution was injected into the NAcc shell To investigate the functional properties of the dopaminergic neurons in the ventral tegmental area (VTA) we used a DREADD system employing AAVs expressing hM4Di with subsequent clozapine N-oxide (CNO We injected 0.5 μL of AAV-mCherry-FLEX-hM4Di virus (2.0 × 1013 copies/ml) into the bilateral VTA regions (L: +/−0.4 H: −4.50) of 6-week-old DAT-Cre mice and TH-Cre mice at a flow rate of 0.25 μL/min 0.1 μg/μl in 10% DMSO (Sigma-Aldrich MO) -saline mixture] was intraperitoneally administered 30 min prior to real-time monitoring of feeding behavior or in vivo microdialysis the same volume of 10% DMSO-saline mixture was administered intraperitoneally and blood glucose were monitored in 8-week-old mice Dissection and collection of tissue samples including brain and brown adipose tissue (BAT) were likewise performed using 8-week-old mice synchronized to the same time schedule as mice in the microdialysis or feeding behavior monitoring experiments Mice were allowed ad libitum access to water and standard bait prior to dissection Blood glucose levels were measured before anesthetization the brain was sectioned with a 1-mm thick brain slicer (MBS-A1C and the hypothalamus was collected under a stereomicroscope and rapidly cooled to −80°C along with the WAT and BAT Rectal temperature measurements and plasma catecholamine concentration determinations were performed immediately after each final stress under anesthesia Rectal temperatures were measured by inserting a probe (TX10-01 Japan) coated with mineral oil (Sigma-Aldrich) into the anus and fixing it at a distance of 2-cm and then measuring the temperature after stabilization The plasma catecholamine concentration was measured by intracardiac blood sampling with samples immediately placed in EDTA-2 K anticoagulant spits (BD Japan Japan) and centrifuged at 1,500 × g for 10 min The supernatant was collected and passed through a clean EG column (CA-50 PBA Eicom) prior to sequential HPLC-ECD (HTEC-510 Eicom) loading to determine the catecholamine concentration Sigma-Aldrich) was used as an internal standard Mouse brains were fixed in 4% paraformaldehyde and cut into 40-μm-thick sections using a vibratome (Leica Biosystems The sections were blocked using blocking solution (X0909 CA) for 1 h followed by overnight incubation with anti-TH antibody (AB152 Sigma-Aldrich) diluted in antibody diluent (S0809 Alexa-488-conjugated secondary antibody (Thermo Fisher Scientific MA) and DAPI Fluoromount-G (Southern Biotech An RNeasy Mini Kit (Qiagen, Hilden, Germany) was used to isolate total RNA from tissues. cDNA synthesis was subsequently performed using 1 μg total RNA and oligo-dT primers (C110A, Promega, Madison, WI). Transcript levels were assessed via real-time quantitative polymerase chain reaction (qPCR) amplifications using an iQ SYBR Green Supermix (BioRad, Hercules, CA) with primers listed in Supplementary Table S1 on a CFX96 system (BioRad) Thermocycler conditions were 95°C for 3 min followed by 40 cycles of 95°C for 10 s and 55°C for 30 s The relative quantity of each transcript was determined via a standard curve using the cycle thresholds of cDNA serial dilutions normalized to Gapdh levels PCR was performed in triplicate for each sample Statistical analyses were performed using JMP 15 (SAS Institute An Anderson-Darling test was utilized to assess normality within each group Welch’s t test was applied for groups without correspondence whereas a paired t test was employed for groups with correspondence a Mann–Whitney U test was conducted for groups lacking correspondence and the Wilcoxon signed-rank test was applied for groups with correspondence Pearson’s chi-square test was applied to assess the significant association between two categorical variables These procedures are detailed in the figure legends with statistical significance established at p < 0.05 Significant differences in groups were determined by ANOVA with repeated measures as indicated in the Figure legends of in vivo microdialysis The data are expressed as mean ± SEM Statistical analysis was performed on the primary preference ratio (n = 15 for Isolation (F) The spatial feeding patterns of male mice with the intermittent HFD diet or a normal diet (Control) Representative heatmap images reflect the duration of time spent on a bait source as before The duration at each bait source was quantified with a motion capture system and statistical analysis were performed as in (E) (n = 16 for each (G) The spatial feeding patterns of physically restrained and non-restrained male mice (Control) quantification of the duration of time spent at each source and statistical analysis were performed as in (E) (n = 10 for Restraint (H) The spatial feeding patterns of female mice reared in social isolation or in group housing (Control) Representative heatmap images indicate the duration of time spent at a bait source The duration spent at each bait source was quantified using the motion capture system with the sources ranked in decreasing order of duration at each bait position and a preference ratio was determined Statistical analysis was performed on the preference ratio (n = 15 for Isolation n = 16 for Control; Welch’s t test) (I) The spatial feeding patterns of female mice reared on the intermittent HFD or a normal diet (Control) Representative heatmap images reflect the duration of time spent at each bait source as before The duration of time at each bait source was quantified with the motion capture system (n = 16 for both; Welch’s t test) (J) The spatial feeding patterns of physically restrained and non-restrained female mice (Control) quantification of time spent at each source (n = 11 for Restraint n = 12 for Control; Mann–Whitney U test) These results indicate that stress can inhibit the post-feeding responsiveness of dopamine in the NAcc shell (E) The spatial feeding patterns of mice in the Int-HFD + Control and the Int-HFD + DA groups and statistical analysis are as above (n = 10 for Int-HFD + Control n = 9 for Int-HFD + DA (F) The spatial feeding patterns of mice in the Restraint + Control and Restraint + DA groups graphs and statistical analysis are as above (n = 11 for each ***p < 0.001 Although no consistent effects were apparent across the three experimental states in terms of amount of diet consumed and metabolic factors all of the stressors promoted feeding patterns characterized by a state of fixated feeding middle; n = 16 for both Int-HFD and Control (C) Effects of the three stressor conditions (social isolation and physical restraint) were assessed in terms of various metabolic factors including body weight and temperature (rectal temperature) brown (BAT) and white adipose tissue (WAT) levels Results of the measurements across the experimental conditions are depicted via a heatmap (ratio to controls) Note that the norepinephrine data (isolation and restrained) are off scale (D) Quantitative data are shown as comparisons between each respective stress condition (Isolation green) and controls (Isolation group body temperature—n = 8 for both; Int-HFD group body temperature—n = 8 for Int-HFD n = 7 for Control; Restrained body temperature—n = 7 for Restraint n = 8 for Control; Mann–Whitney U test Isolation group plasma norepinephrine—n = 7 for both; intermittent HFD group plasma norepinephrine—n = 6 for Int-HFD n = 7 for Control; Restrained plasma norepinephrine—n = 8 for Restraint n = 7 for Control; Welch’s t test Isolation group others—n = 36 for both; intermittent HFD group others—n = 28 for both; Restrained group others—n = 15 for Restraint n = 16 for Control; Mann–Whitney U test) **p < 0.01 We found that three different external stressors promoted feeding behavior deviations in food selection (fixated feeding) but had inconsistent effects on either the total amount of diet consumed or a number of metabolic factors These findings demonstrate that variations in spatial feeding patterns can be used in lieu of total diet consumption as quantifiable indicators of feeding behavior and that they can enable the detection of stressor-mediated and neuropsychiatric disease-associated changes in the reward system This observation underscores the complex interplay between stress highlighting the role of the dopamine system in mediating the impact of stress on feeding patterns our results indicate that feeding behavior patterns are positively regulated by the dopaminergic system from the VTA to the NAcc shell regardless of the amount of food consumed Considering that dopamine neurons in the VTA are the center of the reward system and that stresses impact dopaminergic neuronal activity in the mesolimbic dopamine system (Bloomfield et al., 2019) changes in feeding behavior patterns may be indicative of impairments to the reward system that are induced by external stress altered feeding behavior patterns may be an early biomarker for a spectrum of neuropsychiatric diseases our study showed that psychosocial and physical stress can rapidly alter feeding behavior patterns via the limbic dopamine system The detection and quantification of these feeding behavior patterns can be powerful tools for investigating the effects of various stressors The original contributions presented in the study are included in the article/Supplementary material further inquiries can be directed to the corresponding authors The animal study was approved by Nagoya University Animal Experiment Committee and the Shiga University of Medical Science Animal Care and Use Committee The study was conducted in accordance with the local legislation and institutional requirements The author(s) declare that financial support was received for the research This work was supported in part by the Japan Agency for Medical Research and Development (AMED); JP20dm0107059 (GS) and by JSPS KAKENHI grant number 21K15622 (YF) and 21H02838 (SI) Additional support was provided by Takeda Science Foundation (YF) and Brain Science Foundation (SI) The authors are grateful to the CARE (The Center for Animal Research and Education) at Nagoya University for technical support for the animal experiments and the Division of Experimental Animals at Nagoya University School of Medicine The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fnins.2024.1349366/full#supplementary-material Crossref Full Text | Google Scholar Optogenetic interrogation of dopaminergic modulation of the multiple phases of reward-seeking behavior Assessment of eating behavior disturbance and associated neural networks in frontotemporal dementia Alonso-Alonso Food reward system: current perspectives and future research needs Arias-Carrión Dopaminergic reward system: a short integrative review Dysregulation of brain reward systems in eating disorders: neurochemical information from animal models of binge eating Changes in food selectivity in children with autism spectrum disorder Emotional eating in relation to worries and psychological distress amid the COVID-19 pandemic: a population-based survey on adults in Norway Crossref Full Text | Google Scholar Targeting Kruppel-like factor 9 in excitatory neurons protects against chronic stress-induced impairments in dendritic spines and fear responses The effects of psychosocial stress on dopaminergic function and the acute stress response Formation of projection pathways from the arcuate nucleus of the hypothalamus to hypothalamic regions implicated in the neural control of feeding behavior in mice Encoding of danger by parabrachial CGRP neurons de Chazeron A case-control study investigating food addiction in Parkinson patients Hypothalamic Agrp neurons drive stereotypic behaviors beyond feeding Crossref Full Text | Google Scholar Natural neural projection dynamics underlying social behavior and eating habits in frontotemporal dementia and Alzheimer's disease Effects of high-fat diet on stress response in male and female wildtype and prolactin knockout mice Money for nothing - atrophy correlates of gambling decision making in behavioural variant frontotemporal dementia and Alzheimer's disease Social isolation during adolescence induces anxiety behaviors and enhances firing activity in BLA pyramidal neurons via mGluR5 upregulation Optogenetically-induced tonic dopamine release from VTA-nucleus accumbens projections inhibits reward consummatory behaviors Neurobiology of food intake in health and disease Food addiction and binge eating: lessons learned from animal models PubMed Abstract | Crossref Full Text | Google Scholar Influence of stress in the onset of eating disorders: data from a two-stage epidemiologic controlled study Crossref Full Text | Google Scholar Overlapping brain circuits for homeostatic and hedonic feeding PubMed Abstract | Crossref Full Text | Google Scholar Crossref Full Text | Google Scholar Neural and molecular mechanisms involved in controlling the quality of feeding behavior: diet selection and feeding patterns Dopamine and addiction: what have we learned from 40 years of research Deficits in mesolimbic reward pathway underlie social interaction impairments in children with autism PubMed Abstract | Google Scholar binge eating and animal models of binge-type eating disorders Dopamine neurons modulate neural encoding and expression of depression-related behaviour Quality and quantity of sleep and factors associated with sleep disturbance in hospitalized patients Identification of a neurocircuit underlying regulation of feeding by stress-related emotional responses Influence of aging and gender differences on feeding behavior and ghrelin-related factors during social isolation in mice Sobue G and Ishigaki S (2024) Stress-impaired reward pathway promotes distinct feeding behavior patterns Received: 04 December 2023; Accepted: 18 April 2024; Published: 09 May 2024 Copyright © 2024 Fujioka, Kawai, Endo, Ishibashi, Iwade, Tuerde, Kaibuchi, Yamashita, Yamanaka, Katsuno, Watanabe, Sobue and Ishigaki. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Gen Sobue, c29idWVnQGFpY2hpLW1lZC11LmFjLmpw; Shinsuke Ishigaki, c2hpbnN1a2VAYmVsbGUuc2hpZ2EtbWVkLmFjLmpw †These authors have contributed equally to this work Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Being a legend means being in the collective memory for eternity Naoko Fujioka is the World Boxing Association 112 lbs she will be between the ropes against the star Marlen Esparza Both fighters will seek to unify their championships: Esparza is the WBC flyweight champion Unification fights among the lower divisions are no common But it is not the only reason why this bout is so important: but the first in a small women’s division Fujioka is in second place while her opponent is in first place.  we know that her golden page has already been written as champion of five different categories and the defeat of other important figures such as Mariana “Barby” Juarez in March 2015 Fujioka presents a powerful punch that has allowed her to score 7 knockouts among her 19 victories has a faster and more frequent punching style She is an Olympic medalist and featured one of the most spectacular clashes in modern women’s boxing; she lost to Seniesa Estrada in 2019.  This is not just another showdown for either boxer It is about the opportunity to be remembered generation after generation The boxing public will enjoy a fierce battle from Texas In a night of mixed emotions at the ANB Arena.. Usage of Content   Confidentiality Clause This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Jersey Number 4Jacob FujiokaPosition: UtilityHeight: 6-0Weight: 185Class: SeniorHometown: Cardiff by the Sea Calif.Prev School: Cathedral Catholic HSBioStatsMediaBioBioStatsMediaLong Beach State (2016): Appeared in all 25 matches … Scored 20 goals … Posted a season-high three goals against Pacific Nov 19 … Had two four-game goals scored streaks … Had six multi-goal matches … Scored two goals against Chapman Sept 24 … Scored two goals against UC San Diego Oct (2015): Appeared in all 29 games while finishing his sophomore season with 14 goals … Had three multi-goal games including a three-goal game in a 19-2 victory over Occidental College … Scored two goals against University of Redlands Sept (2014): Played in all 29 games this season … Scored 5 goals in the season … Had two multi-scoring games both with his goal-high 2 goals … Scored in the 19-4 win against Air Force in the Triton Invitational and against Long Beach City College Cathedral Catholic High School: A three-year letter winner at Cathedral Catholic High School .. A first-team All-North Country Selection .. Also earned a varsity letter in volleyball .. Named the MVP of the AFC Tournament in Coronado One person died and two people were injured after an explosion took place at a factory of Toyota Motor’s affiliate on March 6 Police officers received a call saying that a dust collector inside Chuo Spring's Fujioka plant Employees also said over the phone that the roof of the factory was blown off A 40-year-old man died and two others were injured from the blast There was also a fire but it was extinguished in three hours Officials are investigating the details of the incident An explosion in a building at the Fujioka plant in October 2023 partially suspended operations at production plants.  About Nippon Television Please view the main text area of the page by skipping the main menu. The page may not be displayed properly if the JavaScript is deactivated on your browser (L-R): Jockey Kota Fujioka with trainer Tomokazu Takano after a victory from Namur in the Mile Championship at Kyoto Race Course has died after suffering severe injuries in a mid-race fall at Hanshin April 6 the Japan Racing Association has announced. The grade 1-winning jockey sustained head and chest injuries after being unseated in the seventh race and died in a hospital.  Veteran rider Yutaka Take said: "I have never felt this much pain and sadness I want to race with thoughts of Kota in my heart." Despite getting the assignment at short notice Fujioka said he felt prepared for the test "I'd seen how the filly raced before and was aware of her ability in addition to receiving advice and information from the trainer as well as (Joao) Moreira who had ridden her in her last start," he said following the race.  Sign up for BloodHorse Daily Fujioka's death comes a week after the racing community mourned the loss of popular jockey Stefano Cherchi who died aged 23 following a fall in Australia For more European racing, sales, and bloodstock news, visit RacingPost.com following injuries sustained in a mid-race fall at Hanshin Racecourse on Saturday. The jockey sustained head and chest injuries Kota never regained consciousness and later succumbed to his injuries. The son of a trainer Kota rode over 800 winners during a career that began in 2007 His biggest success came aboard Namur in the 2023 Mile Championship (G1) Veteran rider Yutaka Take told the Racing Post: "I have never felt this much pain and sadness I want to race with thoughts of Kota in my heart." Kota is the third jockey to lose his life in the past month Last week, 23-year-old Stefano Cherchi passed away in a hospital in Australia two weeks after a fall during a race at Canberra 25-year-old Yudai Tsukamoto was killed in a fall on Japan's provincial NAR circuit Read more at The Mirror. and the debates surrounding trainer Bob Baffert JD ’82 took the oath of office in the Rotunda of Frank Ogawa Plaza in Oakland as the first Japanese American woman Superior Court judge in Alameda County but her thoughts turned to two people who weren’t there: her late father Ted was killed in World War II long before she was born but instilled in her the values that led to her career The Fujioka family was among the 120,000 Japanese Americans on the west coast who were forced to abandon their homes and businesses and be imprisoned behind barbed wire in euphemistically named “relocation camps,” where machine gun-toting guards in the towers were ordered to shoot anyone who tried to escape The Fujiokas were sent to the Heart Mountain camp in Wyoming where they had to endure freezing cold in the winter and suffocating heat in the summer with howling winds constantly blowing dust and dirt through the many cracks in the ramshackle barracks.  Many internment camps had schools for the thousands of imprisoned children Ted was elected the first student body president as well as editor of the student newspaper “He aspired to be a lawyer and run for public office one day,” said Fujioka But in 1943 the Army was so desperate for manpower that it created an all-volunteer segregated Japanese American unit called the 442nd Regimental Combat Team (now the most decorated unit for its size and length of service in U.S “The future welfare of all of us who hope to remain in this land rests almost entirely on how the 442nd does in battle We’ve got everything to gain by doing our utmost nothing to lose,” Ted wrote to his parents “We have a chance to prove to all who doubt our loyalty and sincerity to this nation that we are Americans and therefore entitled to live as Americans in the truest sense of the word.” He fought in some of the bloodiest battles of the war including the rescue of the Lost Battalion a Texas national guard unit of 211 men who were trapped behind enemy lines Ted was killed in action in the Vosges Mountains at age 19 His family got the news in a telegram sent to them at Heart Mountain followed by a Purple Heart some time later he determined to live his life according to the values that Ted had taught him “Uncle Ted has been my inspiration my entire life “He instilled in me a sense of duty to my family be sure you do it for the good of others.’  “Dad often spoke of the qualities that he and many others admired about Ted: intelligence and his willingness to prove his loyalty by fighting in the 442nd for the principles he believed in – ‘democracy peace.’ These words inspire me every day.” Margaret was born in Los Angeles and attended public schools from kindergarten to law school She came north to go to Berkeley and never left After getting her law degree from Hastings and an Administrative Hearing Officer for San Francisco She is the former president of both the National Asian Pacific American Bar Association and the Asian American Bar Association of the Greater Bay Area In 2008 she ran for Piedmont City Council and won handily in a hotly contested election She ran for re-election in 2012 and easily won again In 2014 her colleagues unanimously elected her mayor Among her accomplishments: creating the city’s first public safety committee dedicated to increasing public safety and disaster preparedness and bringing the city’s technological infrastructure into the 21st Century thoughtful or professional than Margaret,” says former Mayor Bob McBain who served with Fujioka on the Piedmont City Council “She treated everyone – even the most contentious – with respect.” she ran for an open seat on the Alameda County Superior Court and She was re-elected to a second six-year term in 2022 “I was once told by a good friend who was a judge that this is the best job in the legal profession,” said Fujioka Alameda County Superior court judges generally rotate assignments and she’s currently presiding over criminal jury trials and preliminary hearings and to listen to everyone so they all feel they’ve had their day in court it takes thought and preparation on the judge’s part because the consequences of a criminal trial are so great both to the victim and the defendant.”  everyone has to be respectful of each other and follow the rules If the judge sets a positive tone at the beginning it carries through and makes the whole process more comfortable for everyone her counterpart on the Contra Costa Superior Court says she has the perfect temperament for the job “In the face of intense pressure and heated opinions Margaret doesn’t use threats or try to bully people,” she says “It’s her sense of fairness and respect for others that gives her such gravitas.” Her dad and uncle Ted wouldn’t have wanted it any other way Reach Martin Snapp at catman442@comcast.net Ever hear that old cliché “This ain’t rocket science?” I wouldn’t use it around Ashley Chandler Karp because what she does is rocket science A propulsion engineer at NASA’s Jet Propulsion Laboratory in Pasadena she’s helping design the next generation of rockets which will bring samples from Mars back to Earth for more extensive testing […] Julie Otsuka has been awarded the 2012 PEN/Faulkner Award for her second novel a California native who studied art at Yale and later took her MFA at Columbia a few months after the Japanese attack on Pearl Harbor A proposed state constitutional amendment that aimed to diversify California’s public universities—but which some opponents dubbed “the most racist bill in the history of California”—has been put on ice This week’s news that Senate Constitutional 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Remember Ben with a gift to Thoroughbred aftercare Subscribe for FREE to the Daily PDF or the News Alerts Home » Archive » Top News Europe » Group 1-Winning Jockey Kota Fujioka Succumbs To Injuries From Race Fall Namur and Kota Fujioka winning the Mile Championship | Japan Racing Association Japanese jockey Kota Fujioka has died from injuries sustained in an Apr the Japanese Racing Association (JRA) announced on Thursday The 35-year-old Group 1-winning rider was dislodged from his horse during the seventh race at Hanshin and sustained head and chest injuries He never regained consciousness his brother revealed on Wednesday to NetKeiba Fujioka was the son of JRA trainer Kenichi Fujioka and the younger brother of JRA jockey Yusuke Fujioka as he won on debut aboard a horse his father trained–Yamanin Prologue (Jpn) (French Deputy)–on Mar Not a subscriber? Click here to sign up for the daily PDF or alerts. Copy Article Link Editor / News Stories:editor@thetdn.com Advertising:advertising@thetdn.com Customer Service:customerservice@thetdn.com Click Here to sign up for a free subscription Fujioka was elected to the Alameda County Superior Court on June 7 She is currently assigned to Collaborative Courts She serves on the Criminal Law Executive Committee of the Alameda County Bar Association Fujioka was an administrative hearing officer with Oakland and before that was a deputy city attorney in the Oakland City Attorney’s Office Fujioka was elected to the Piedmont City Council in 2008 and re-elected in 2012 with the highest number of votes in both contested races She served as Piedmont’s mayor from 2014-2016 Fujioka is a past president of the National Asian Pacific American Bar Association and the Asian American Bar Association of the Greater Bay Area She received her bachelor’s degree from the University of California and her law degree from UC Hastings College of the Law Metrics details Whereas Atg proteins that associate with the PAS have been characterized the physicochemical and functional properties of the PAS remain unclear owing to its small size and fragility Here we show that the PAS is in fact a liquid-like condensate of Atg proteins The autophagy-initiating Atg1 complex undergoes phase separation to form liquid droplets in vitro and point mutations or phosphorylation that inhibit phase separation impair PAS formation in vivo In vitro experiments show that Atg1-complex droplets can be tethered to membranes via specific protein–protein interactions explaining the vacuolar membrane localization of the PAS in vivo We propose that phase separation has a critical whereby it organizes the autophagy machinery at the PAS Prices may be subject to local taxes which are calculated during checkout All relevant data are available from the authors Source data for gels and blots are provided as Supplementary Information Source Data for graphs are provided with the paper Biomolecular condensates: organizers of cellular biochemistry Liquid phase condensation in cell physiology and disease The pre-autophagosomal structure organized by concerted functions of APG genes is essential for autophagosome formation Convergence of multiple autophagy and cytoplasm to vacuole targeting components to a perivacuolar membrane compartment prior to de novo vesicle formation and autophagic degradation of proteins in development and pathogenesis The intrinsically disordered protein Atg13 mediates supramolecular assembly of autophagy initiation complexes Hierarchy of Atg proteins in pre-autophagosomal structure organization Atg9 vesicles are an important membrane source during early steps of autophagosome formation Organization of the pre-autophagosomal structure responsible for autophagosome formation The Atg1 kinase complex is involved in the regulation of protein recruitment to initiate sequestering vesicle formation for nonspecific autophagy in Saccharomyces cerevisiae Phase behaviour of disordered proteins underlying low density and high permeability of liquid organelles Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis Kroschwald, S., Maharana, S. & Simon, A. Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters 1–7, https://doi.org/10.19185/matters.201702000010 (2017) Cell adaptation upon stress: the emerging role of membrane-less compartments Structural basis of starvation-induced assembly of the autophagy initiation complex Tor-mediated induction of autophagy via an Apg1 protein kinase complex Autophosphorylation within the Atg1 activation loop is required for both kinase activity and the induction of autophagy in Saccharomyces cerevisiae Receptor-bound targets of selective autophagy use a scaffold protein to activate the Atg1 kinase Two independent pathways within selective autophagy converge to activate Atg1 kinase at the vacuole PP2C phosphatases promote autophagy by dephosphorylation of the Atg1 complex Architecture of the Atg17 complex as a scaffold for autophagosome biogenesis Organization and function of non-dynamic biomolecular condensates Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting Mechanistic insight into the nucleus-vacuole junction based on the Vac8p–Nvj1p crystal structure A liquid phase of synapsin and lipid vesicles BoxPlotR: a web tool for generation of box plots Prediction and functional analysis of native disorder in proteins from the three kingdoms of life Methods in Yeast Genetics (Cold Spring Harbor Laboratory Press Fiji: an open-source platform for biological-image analysis Studying slow membrane dynamics with continuous wave scanning fluorescence correlation spectroscopy Accurate determination of membrane dynamics with line-scan FCS Non-parametric estimation of intensity maps using Haar wavelets and Poisson noise characteristics Non-parametric estimation of gamma-ray burst intensities using Haar wavelets Technical Report CS-R9526 (Centrum voor Wiskunde en Informatica Fast multi-tau real-time software correlator for dynamic light scattering High-speed atomic force microscope combined with single-molecule fluorescence microscope Probing structural dynamics of an artificial protein cage using high-speed atomic force microscopy The single-giant unilamellar vesicle method reveals lysenin-induced pore formation in lipid membranes containing sphingomyelin Spontaneous insertion of lipopolysaccharide into lipid membranes from aqueous solution Stretch-activated pore of the antimicrobial peptide The single GUV method to reveal elementary processes of leakage of internal contents from liposomes induced by antimicrobial substances Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae Download references Goldfarb for providing plasmids and strains for yeast experiments Ishii for assistance with protein preparation and H This work was supported in part by JSPS KAKENHI grant number 25111004 JST CREST grant number JPMJCR13M7 (to N.N.N.) Okada) and grants from RIKEN (pioneering project ‘Dynamic Structural Biology’ to Y from the Takeda Science Foundation (to N.N.N from Mochida Memorial Foundation for Medical and Pharmaceutical Research (to N.N.N.) from Tokyo Biochemical Research Foundation (to N.N.N Institute of Microbial Chemistry (BIKAKEN) Center for Biosystems Dynamics Research (BDR) Universal Biology Institute (UBI) and International Research Center for Neurointelligence (WPI-IRCN) Tokyo Tech World Research Hub Initiative (WRHI) Max Planck Institute of Colloids and Interfaces Max Planck Institute of Molecular Plant Physiology Collaborative Research Institute for Innovative Microbiology conceived the project and performed initial droplet-formation experiments purified recombinant proteins and performed most of the in vitro experiments wrote the manuscript with input from all other authors The authors declare no competing interests Peer review information Nature thanks Peter Hinterdorfer Jeffrey Woodruff and Li Yu for their contribution to the peer review of this work Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Phase diagram of droplet formation upon mixing of Atg13 and Atg17–Atg29–Atg31 at indicated protein concentrations b and c in the diagram are shown above the diagram Photobleaching experiments were performed for the scaffold droplets in vitro White and yellow arrow heads indicate photobleached and non-bleached droplets Photobleaching was performed between 0 and 3 s Experiments were repeated independently twice with similar results FRAP experiments of Atg1–SNAP in Atg1-complex droplets attached to Vac8-anchored multilamellar vesicles Multilamellar vesicles were used instead of GUVs to reduce the movement of droplets on vesicles The bottom graph indicates the ratio of fluorescence intensity at each time point in comparison to the initial intensity Data from seven independent experiments are shown hyperphosphorylation of Atg13 by TORC1 inhibits Atg1-complex formation and phase separation TORC1 activity is inhibited and Atg13 is dephosphorylated by PP2C phosphatases The Atg1 complex then undergoes phase separation to form a liquid droplet (early PAS) which is tethered to the vacuolar membrane through Atg13–Vac8 interaction The early PAS activates Atg1 kinase by accelerating autophosphorylation and at the same time recruits downstream Atg factors thereby transforming into the mature PAS from which isolation membrane is generated Continuous phosphorylation and dephosphorylation of Atg13 at the PAS would contribute to maintaining the liquid property of the PAS Supplementary Figure 1: Uncropped gel images Supplementary Table 1: Yeast strains used in this study Supplementary Table 2: Plasmids used for yeast experiments in this study Rapid recovery of fluorescence of overexpressed GFP-Atg13 puncta after photobleaching This video was used to create the images presented in Fig Photobleaching was performed at frame 6 in this video Rapid recovery (within 0.7 s) in a partially quenched region at the centre of the giant PAS after photobleaching Partial photobleaching was performed at frame 6 in the video Effect of 1,6-hexanediol treatment on the PAS 1e assessing the effect of 1,6-hexanediol treatment on Atg13-GFP puncta formation Multiple Atg13-GFP puncta form in response to rapamycin treatment (10 min) before coalescing into a larger droplet This video was used to generate the images shown in Fig Close-up of two Atg13-GFP puncta coalescing to form a single punctum This video was used to generate the images and aspect ratio data presented in Fig Video of Ostwald ripening of Atg13-GFP puncta shown in Fig HS-AFM observation of Atg17 molecules in droplets HS-AFM videos of Atg17-SNAP in scaffold droplets on non-coated coverslip before (top) and after FFT bandpass filter (bottom) HS-AFM observation of Atg17 molecules in mature droplets HS-AFM videos of Atg17-SNAP in scaffold droplets on a 3-aminopropyltriethoxysilane-coated coverslip before (top) and after FFT bandpass filter (bottom) Early PAS droplets on Vac8-GUVs coalesce to form fewer but larger droplets Video of scaffold droplets attached to Vac8-GUVs Three different fluorescence signals (blue SNAP-Surface Alexa Fluor 647 from Atg17) were merged to create this video Download citation DOI: https://doi.org/10.1038/s41586-020-1977-6 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Nature Structural & Molecular Biology (2025) Sign up for the Nature Briefing newsletter — what matters in science