Installation view: Ryoji Ikeda: data-verse Between the infinite and nothingness lies the “data-verse.” This dialectic is at the center of Ryoji Ikeda’s first museum exhibition in the United States at the High Museum of Art Ryoji Ikeda: data-verse builds on the artist’s growing critical acclaim and affirms his reputation for complex technological work the exhibition begins with a loosely connected series of installations which explore the poetic and phenomenological effects of Ikeda’s attempts to materialize light and sound The show opens with point of no return (2018) an immense pulsing white screen with a slowly dilating black hole at its center The work’s visual economy of means masks its complex relational effects and symbolic overtones As the viewer walks closer and contemplates the piece the black hole at the center appears to be reconfigured from a flat two-dimensional image into an immersive field pulsing energy of the white screen disappears amidst the stilled this transformation mimics the notion that the viewer has been pulled inside the black hole’s magnetic field the viewer is visually re-grounded within the space of the gallery as the pulsing light returns and the black hole once again becomes a flattened two-dimensional image Point of no return is both an invitation to the viewer and a philosophical query which prefaces the remaining works in the exhibition The black hole at its center is suggestive of the moment in the universe before the Big Bang The remaining installations of this initial series—mass (2023) and line (2008)—explore that expansion when light emerged from darkness and yielded matter Mass features similar black-and-white circular forms which ripple across a large screen placed directly on the floor low-lit gallery whose black walls absorb light the images on the massive screen seem to take on three-dimensional form appearing to open into a swirling abyss below Ikeda’s play with optical illusion transforms the continuously decentering circular form on screen into a three-dimensional sphere teetering above its seemingly limitless depth mass’s vertiginous effect is deeply humbling a reminder of humanity’s infinitesimal place within the universe plays with optical illusion through an economy of visual means while cheekily laying bare its own making the work appears at the end of a long hallway as a single thin line of light bursting from the darkness Its totemic elegance beckons viewers to draw near evocatively playing with the potential transcendence manifested in walking towards the light as it becomes apparent that the light does not emanate from a bulb or screen from a slit cut into the gallery wall which allows for the light of the window behind the wall to shine through The work's simplicity conceals its metaphysical complexity Like Barnett Newman’s “zip,” Ikeda’s line upends figure-ground relations but does so while sculpting light as Ikeda corrals the immateriality of light into geometric form Line leads viewers to the exhibition’s eponymous work It is composed of three monumental screens each of which features distinct yet interrelated chapters of large-scale Masterfully transformed into lush imagery and synchronized to an electronic score data-verse 1/2/3 eschews the visual restraint of Ikeda’s earlier installations in favor of operatic form If line evokes the “zip,” data-verse 1/2/3 is the sublime pulsing images weave together datasets at the thresholds of both micro and macroscopic perception; from subatomic particles and protein structures to solar irradiance and maps of galaxies the piece transforms mathematical planes into a dazzling hypnotic display of the universe’s wonders At the center of Ikeda’s explorations is an ethics of scalar relationality The viewer first encounters these questions in relation to a singular body of knowledge whose various datasets are simultaneously displayed across the three screens shifts from cellular splices to musculoskeletal scans The connection between these datasets is punctuated by Ikeda’s electronic score as a sharp metallic chime visually runs across the screens This tripartite visualization is echoed in the expanding scale of the datasets themselves which map increasingly larger fields of relationality From biological interactions within the body to the social engagements revealed in traffic grids and stock market charts the screens display steadily larger points of relation the heat maps of the sun’s radiation burn across the screens The ethical query at the center of the sublime and the question of the figure-ground relation which Ikeda explores in his work resurfaces in data-verse instead of exploring the visual phenomenologies of light as geometric form Helena Shaskevich is an Assistant Professor of Art History at Kennesaw State University, specializing in feminist new media from the 1960s to the present. Her writing has been published in Feminist Media Histories, Camera Obscura, Art Journal, Woman’s Art Journal, Millennium Film Journal, Afterimage, and multiple collected volumes. Home Metrics details A Publisher Correction to this article was published on 13 February 2025 This article has been updated detailed mechanisms of such processes remain unclear Here we analyse clinical specimens and identify mitochondrial DNA (mtDNA) mutations in TILs that are shared with cancer cells mitochondria with mtDNA mutations from cancer cells are able to transfer to TILs mitochondria in TILs readily undergo mitophagy through reactive oxygen species mitochondria transferred from cancer cells do not undergo mitophagy which we find is due to mitophagy-inhibitory molecules These molecules attach to mitochondria and together are transferred to TILs T cells that acquire mtDNA mutations from cancer cells exhibit metabolic abnormalities and senescence with defects in effector functions and memory formation This in turn leads to impaired antitumour immunity both in vitro and in vivo the presence of an mtDNA mutation in tumour tissue is a poor prognostic factor for immune checkpoint inhibitors in patients with melanoma or non-small-cell lung cancer These findings reveal a previously unknown mechanism of cancer immune evasion through mitochondrial transfer and can contribute to the development of future cancer immunotherapies identification of the various immune-evasion mechanisms that cancer cells use is essential to improve ICI efficacy the mechanisms that underlie mitochondrial dysfunction in TILs remain unclear Although mitochondrial transfer can occur from cancer cells to T cells in the TME the incidence and effects of this process on antitumour immunity remain unclear Here we analyse clinical samples of various cancer types and show that mtDNA mutations are present in TILs Many of these mtDNA mutations are shared with the cancer cells and are obtained through mitochondrial transfer We also investigate the functions of mtDNA-mutated T cells including antitumour immunity mediated by PD-1 blockade The clinical significance of these results in patients with melanoma or non-small-cell lung cancer (NSCLC) receiving ICIs is also evaluated This study reveals a previously undescribed immune-evasion mechanism that involves mitochondrial transfer Integrative Genomics Viewer (IGV) track data of the entire mtDNA from paired TILs and cancer cells from the same patient (02 and 04) A lymphoblastoid cell line (LCL) established from PBLs from the same patient (through Epstein–Barr virus transformation) was used as germline controls Representative gating strategy for bulk TIL analyses Capillary sequencing chromatograms of mtDNA from patient 04 mtDNA from sorted pure CD45+CD3+ T cells from bulk TIL04 cells MEL04 cells and PBL04 cells were sequenced representative transmission electronic microscopy images of bulk TIL04 the number of cristae per mitochondrion (n = 20 per mitochondrion) were counted and quantified IGV track data of the entire mtDNA of FFPE tumour tissue from patient 04 next-generation sequencing was used for analyses P  values (shown on the chart) were calculated using one-way analysis of variance (ANOVA) with Bonferroni correction (d) Source Data n = 4 per group) and capillary sequencing chromatograms for DsRed− cells (i P values (shown on charts) were calculated using one-way ANOVA with Bonferroni corrections (c,h) Source Data TIL04#9 cells labelled with MitoTracker Green were cocultured with MEL04 cells for 3 days (a Representative flow cytometry staining (left) and quantification (right) are shown (n = 4 per group) Capillary sequencing chromatograms of mtDNA in TIL04#9 cells cocultured with MEL04 cells with or without NAC at day 14 TIL04#9 cells labelled with MitoTracker Green were cocultured with MEL04-MitoDsRed cells for 3 days and were subsequently stained and analysed Representative confocal microscopy images (d) and quantification (e) are shown (n = 4 per group) carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone TIL04#9 cells were cocultured with MEL04-MitoDsRed cells for 14 days and sorted TILs were analysed by real-time PCR Quantification of fold change values to the controls are shown (n = 3 per group) Quantification of mitochondria in TIL04#9 cells treated with a mitophagy inhibitor Coculture was performed as described in a with or without bafilomycin A1 and TILs were subsequently analysed Representative confocal microscopy images (h) and quantification (i) are shown (n = 4 per group) Quantification of mitochondrial transfer in TILs treated with a USP30 inhibitor or siRNAs TIL04#9 cells were cocultured with MEL04-MitoDsRed cells for 3 days with or without CMPD-39 or siRNAs and were subsequently analysed Capillary sequencing chromatograms of mtDNA in TIL04#9 cells cocultured with MEL04 cells with or without CMPD-39 or siRNAs at day 14 P values (shown on charts) were calculated using two-sided t-tests (a,b,i) or one-way ANOVA with Bonferroni corrections (e–g,j) Source Data confer resistance to mitophagy in mitochondria transferred from cancer cells which may be partially related to homoplasmic replacement mitochondria transferred from cancer cells along with mitophagy-inhibitory molecules do not undergo mitophagy whereas in situ mitochondria in T cells undergo mitophagy owing to cancer-derived ROS which results in the replacement of mitochondria These results indicate that these mutated mitochondria have impaired function The following parameters were analysed in TILs established in a: membrane potentials evaluated using MitoTracker Deep Red and Green (b); cellular ROS production evaluated using DCFDA (c); β-galactosidase activity (d); p16 (e) and p53 (f) expression; CD27−CD28− senescent fraction (g); IL6 (h) CXCL8 (i) and IL1B (j) expression; rapidly dividing cells evaluated using Annexin V (l); frequencies of CCR7highCD45RAlow central memory (m) and KLRG1low long-lived (n) fractions; and PD-1 (o) and CD69 (p) expression TILs were stimulated with anti-CD3 and anti-CD28 monoclonal antibodies Rapidly dividing cells were counted after the third division on day 3 Quantifications are shown (n = 4 per group) P values (shown on charts) were calculated using one-way ANOVA with Bonferroni corrections (b–p) Source Data these results show that T cells that receive cancer-cell-derived mtDNA-mutated mitochondria can become senescent and have defects in effector functions and memory formation the transfer of mtDNA-mutated mitochondria through EVs from cancer cells can also cause mitochondrial dysfunction in T cells P values (shown on charts) were calculated using two-sided t-tests (a,i) one-way ANOVA with Bonferroni corrections (b–g,j–n) or two-way ANOVA with Bonferroni corrections (h) Source Data these results show that mtDNA-mutated mitochondria transferred from cancer cells to TILs can reduce antitumor immunity We sequenced mtDNA in TILs and frequently detected shared mutations with cancer cells we demonstrated that mtDNA-mutated mitochondrial transfer from cancer cells to T cells in the TME leads to T cell dysfunction the presence of mtDNA mutations in tumour tissue samples predicted poor outcomes in PD-1 blockade therapies These findings suggest that mtDNA-mutated mitochondrial transfer from cancer cells to TILs causes mitochondrial dysfunction and impairments in antitumour immunity many mtDNA mutations in cancer cells can induce mitochondrial dysfunction in TILs through mitochondrial transfer We observed that 75% of mtDNA mutations in TILs were shared with cancer cells which indicates that TILs frequently receive mitochondria through transfer from cancer cells mtDNA mutations were found in 5 out of 12 TILs a frequency similar to that observed in FFPE tumour sequencing although we could not accurately evaluate mtDNA mutations in TILs from FFPE samples most mtDNA mutations in TILs are probably transferred from cancer cells These results confirm the importance of T cell mitochondria may not be necessary to affect T cell function we identified mtDNA mutations in TILs as a cause of mitochondrial dysfunction Many mutations were shared with cancer cells and mitochondrial transfer from cancer cells to TILs probably occurs Mutated T cells exhibited metabolic abnormalities and senescence which in turn affected PD-1 blockade immunity Patients with mtDNA mutations treated with PD-1 blockade therapy had a poor prognosis These findings highlight a previously unknown immune-evasion mechanism of cancer cells that uses mitochondrial transfer surgically resected samples were enzymatically digested with 0.1% collagenase 0.01% hyaluronidase and 30 U ml–1 deoxyribonuclease (Sigma-Aldrich) in RPMI1640 (Thermo Fisher Scientific) at room temperature The digested tumour cells were subjected to filtration and density-gradient separation before use Peripheral blood mononuclear cells were obtained from donated blood and through Ficoll–Uropoline density-gradient centrifugation All participants provided written informed consent Clinical information on the participants was obtained from their medical records Informed consent was obtained by the patient opting out on the website of our institutions The protocol for this study was approved by the appropriate institutional review boards and ethics committees of Yamanashi University Hospital Kindai University Hospital and Saitama Medical University International Medical Center This study was conducted in accordance with the principles of the Declaration of Helsinki Allele frequencies computed by EAGLE (--hetbias=0 and –omega=1e-6) were used as the basis for subsequent variant analyses Variants labelled as ‘hotspot’ and ‘local private variant’ were regarded as polymorphic variants; filtered variants were visually inspected to exclude probable sequencing errors at the termini of PCR amplicons or in homopolymer sequence stretches confirmed through a paired analysis of matched tumour and normal tissue samples (n = 45) with variants that were called only from tumour samples true variants were called with a false-positive rate of 0% and a false-negative rate of 12.2% the overall mtDNA variant status was classified as truncating samples were divided into mtDNA-mutation-positive if they presented truncating 35.7%) and mtDNA-mutations-negative if they had a D-loop or an intergenic site or had silent or no variants 1 × 107 digested tumour cells were cultured in RPMI1640 medium containing 10% FBS (Cytiva) 1% penicillin–streptomycin (PS) and 1% amphotericin B (Thermo Fisher Scientific) Tumour cells were passaged at approximately 80–90% confluence and used when free of fibroblasts and proliferating beyond the tenth passage tumour digests were incubated in RPMI1640 medium supplemented with 10% human AB serum 1% PS and recombinant human interleukin-2 (rhIL-2: 6,000 IU ml–1 PeproTech) in a humidified 37 °C incubator with 5% CO2 Half of the medium was aspirated from the wells and replaced with fresh complete medium and rhIL-2 every 2–3 days LLC/P29 and LLC/A11 cells were maintained in Dulbecco’s modified Eagle’s medium (DMEM; Thermo Fisher Scientific) and Jurkat cells were cultured in RPMI1640 medium containing 10% FBS and 1% PS in a humidified 37 °C incubator with 5% CO2 mtDNA-deficient Jurkat (Jurkat/Rho0) cells were generated by culturing Jurkat cells in the presence of 200 ng ml–1 ethidium bromide for 6 weeks and then maintained in RPMI1640 medium containing 10% FBS 100 μg ml–1 sodium pyruvate and 50 μg ml–1 uridine All cell lines were used after confirming that they were mycoplasma-free which was assessed using a PCR Mycoplasma Detection kit (Takara) according to the manufacturer’s instructions containing 2% glutaraldehyde and 2% paraformaldehyde for 16–18 h Post-fixation was performed with 2% osmium tetroxide for 1.5 h the specimens were dehydrated in a graded ethanol series and embedded in a low-viscosity resin (Spurr resin 80-nm-thick sections were prepared using an ultramicrotome (EM-UC7; Leica) and stained with uranyl acetate and lead citrate The specimens were observed using a transmission electron microscope (H-7650 We counted and quantified the number of cristae per mitochondrion 12259) into packaging cells using Lipofectamine 3000 reagent the supernatants were concentrated and transduced into cell lines MEL02 The transfected cell lines were named MEL02-MitoDsRed LLC/P29-OVA-MitoDsRed and LLC/A11-OVA-MitoDsRed cell lines were also generated Capillary sequencing and several primers were used to check the status of mtDNA in cell lines and TILs (Supplementary Table 5) PrimeSTAR GXL DNA Polymerase (Takara) and the primers were prepared in 96-well plates for sequencing before cell sorting CD3+CD45+ T cells were sorted from TILs at the single-cell level into 96-well plates using a cell sorter (FACSMelody; BD Biosciences) Oligonucleotides were amplified by PCR and sequenced (Eurofins Genomics) TIL04#9 and MEL04 cells were labelled with MitoTracker Green (Thermo Fisher Scientific) and MitoDsRed 2 × 105 MEL04-MitoDsRed cells were cocultured with labelled 1 × 106 TIL04#9 cells in a 35-mm glass-bottom culture dish for 2 days and observed under a Leica TSC SP8 confocal laser microscope (Leica Microsystems) without fixation TIL04#9 cells were labelled with a BV421-conjugated monoclonal antibody specific for CD45 (clone HI100 To quantify the transfer of mitochondria from T cells to cancer cells, we used OT-1 and PhaMexcised mice expressing mitochondrial-specific fluorescence (mito-Dendra2), which were obtained from the Jackson Laboratory (Supplementary Fig. 2) OVA-overexpressing LLC/A11 cells were cocultured with or without CD8+ T cells from PhaMexcised OT-1 mice for 3 days floating T cells were discarded and LLC/A11 cells were repeatedly washed with PBS These cells were subsequently analysed by flow cytometry as CD45– cells To quantify in situ mitochondria in T cells TIL04#9 cells were labelled with MitoTracker Green for 24 h and then cocultured with MEL04 cells with or without 10 mM NAC for 3 days 100 nM of a mitophagy inhibitor (bafilomycin A1; Adipogen Life Sciences) was added every 12 h for 3 days OVA-overexpressing LLC/A11 cells or MEL04 cells were labelled with MitoTracker Green labelled OVA-overexpressing LLC/A11 cells or MEL04 cells were cocultured with or without CD8+ T cells from OT-1 mice or TIL04#9 cells for 3 days Floating T cells were then discarded and OVA-overexpressing LLC/A11 cells or MEL04 cells were repeatedly washed with PBS These cells were then analysed by flow cytometry as CD45– cells TIL04#9 cells were labelled with MitoTracker Green TIL04#9 cells were cocultured with MEL04-MitoDsRed cells for 3 days with or without 10 mM NAC the cells were stained with an LC3B-specific polyclonal antibody (Proteintech 18725-1-AP) followed by an APC-conjugated secondary antibody (goat anti-rabbit IgG and observed under a confocal laser microscope or analysed by flow cytometry We used 10 μM carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone (FCCP) (Selleck Biotech) as a positive control We obtained RNA-sequencing expression data from The Cancer Genome Atlas (TCGA) in the Genomic Data Commons data portal of patients with melanoma from the USCS Xena database (https://xenabrowser.net) USP33 and USP35 expression data in tumour tissues were used TIL04#9 cells were labelled with MitoTracker Green and cocultured with MEL04-MitoDsRed cells for 3 days TIL04#9 cells were stained using an AF546-conjugated anti-USP30 monoclonal antibody (Santa Cruz Biotechnology B-6) or an anti-USP30 polyclonal antibody (Proteintech 15402-1-AP) with APC-conjugated secondary monoclonal antibody and observed under a confocal laser microscope or analysed by flow cytometry We also evaluated cytochrome c as a mitochondrial protein We used a DCFDA/H2DCFDA Cellular ROS Assay kit (Abcam) to detect ROS PBL04 cells and MEL04 cells were incubated with 20 μM DCFDA solution for 30 min at 37 °C in 5% CO2 we extracted and purified EVs from the cells and analysed them by flow cytometry with a PS Capture Exosome Flow Cytometry kit (Wako) to create EV-conjugated beads and medium used for the culture of MEL02 and MEL04 cells were separated by SDS–PAGE and blotted onto polyvinylidene fluoride membranes (Merck Millipore) The membranes were blocked and then incubated with primary antibodies the membranes were incubated with horseradish peroxidase (HRP)-conjugated secondary antibodies the bands were detected using Clarity Western ECL substrate (Bio-Rad) or ImmunoStar LD (Wako) and confirmed using a LAS4000 system (Cytiva) The protein concentration in each sample was evaluated and adjusted to each other using Pierce BCA Protein Assay kits (Thermo Fisher Scientific) according to the manufacturer’s instruments Reactions were conducted at 25 °C using a FlexStation 3 microplate reader (Molecular Devices) with readings taken every 30 s for 15 min at the Central Research Laboratory of the Okayama University Medical School We cocultured wild-type mtDNA TIL04#9 or TILc03#5 cells with melanoma (MEL02-MitoDsRed mutated) cells for 14 days and subsequently sorted the TILs according to DsRed expression The sorted TILs were named as follows: DsRed−TIL04#9/02 (wild type) DsRed−TILc03#5/c03 (wild type) and DsRed+TILc03#5/c03 cells (mutated) Sorted CCR7highCD45RAhighCD8+ naive T cells from PBLs of healthy donors were cocultured with MEL02-MitoDsRed cells or MEL04-MitoDsRed cells for 7 days while being stimulated with an anti-CD3 monoclonal antibody (50 ng ml–1) in the presence of rhIL-7 (10 ng ml–1 The central memory fraction and KLRG1 expression level were analysed by flow cytometry CCR7lowCD45RAlow; terminally differentiated effector memory CCR7lowCD45RAhigh) sorted from PBLs of healthy donors was also cocultured with MEL02-MitoDsRed cells or MEL04-MitoDsRed cells for 4 days in the presence of IL-2 (300 IU ml–1) alone and apoptosis was analysed by flow cytometry The isolated mitochondria were added to Jurkat/Rho0 cells which were subsequently incubated for 24 h after centrifugation (2,000g for 15 min) This procedure was repeated four times weekly EVs isolated using the above-described protocols were added to Jurkat/Rho0 cells using the EV-Entry system (System Biosciences) which were immediately centrifuged at 1,500g for 15 min at 4 °C and incubated overnight These EV-transferred Jurkat/Rho0 cells were cultured for 6 weeks and this procedure was repeated every 5–7 days each Jurkat cell was stained with 250 nM TMRE (Thermo Fisher Scientific) incubated at 37 °C in 5% CO2 for 20 min and then analysed by flow cytometry Metabolic analyses were performed using a flux analyser (Seahorse XF HS mini according to the manufacturer’s instructions 0.8 × 105 cells were seeded in supplemented Seahorse XF RPMI medium containing 1 mM pyruvate 2 mM glutamine and 10 mM glucose (pH 7.4) in poly-d-lysine-coated XFp miniplates followed by centrifugation at 200g for 1 min at room temperature The plate was then equilibrated at 37 °C in an incubator without CO2 for 40 min The oxygen consumption rate was evaluated with sequential injections of oligomycin (1 μM) FCCP (0.75 μM) and rotenone–antimycin A (0.5 μM) The extracellular acidification rate was evaluated by sequential injections of glucose (10 mM) oligomycin (1 μM) and 2-deoxy-glucose (50 mM) The ATP production rate was evaluated with sequential injections of oligomycin (1.5 μM) and otenone–antimycin A (0.5 μM) All chemicals were purchased from Agilent Technologies All data were normalized to the cell number we used a DCFDA/H2DCFDA Cellular ROS Assay kit (Abcam) A Cellular Senescence Detection kit (Dojindo) was used to assess cellular senescence according to the manufacturer’s instructions cells were incubated with bafilomycin A1 for 1 h at 37 °C in 5% CO2 then incubated with SPiDER-β-Gal for 30 min and analysed by flow cytometry Apoptosis was evaluated by combining Annexin V (Thermo Fisher Scientific) and eBioscience Fixable Viability Dye eFluor (Thermo Fisher Scientific) for live/dead cell staining According to the manufacturer’s instructions each cell was incubated with Annexin V and eFluor for 15 min at room temperature and then analysed by flow cytometry Cellular proliferation was assessed on the basis of the dilution of cells labelled with carboxyfluorescein succinimidyl ester (CFSE) using a CFSE Cell Proliferation kit (Thermo Fisher Scientific) and flow cytometry Cells were incubated with 10 μM CFSE for 20 min at 37 °C in 5% CO2 washed 3 times with RPMI medium and incubated for 3 days followed by additional live/dead cell staining and flow cytometry analysis Twenty-four hours after cells (103) were passaged on 96-well plates in vitro cellular proliferation was evaluated using an IncuCyte ZOOM System (Essen BioScience) every 6 h for 48 h Female C57BL/6J mice (6–8 weeks old) were purchased from SLC Japan C57BL/6J- Prkdc<scid>/Rbrc mice (B6 SCID) were provided by RIKEN BRC through the National BioResource Project of the Japan Ministry of Education Science and Technology/Agency for Medical Research and Development Cd4cre and Tfamfloxed mice (Tfam; mitochondrial transcription factor A) were purchased from the Jackson Laboratory Rat anti-mouse PD-1 monoclonal antibody (RMP1-14) and anti-mouse CD8β monoclonal antibody (Lyt 3.2) were obtained from Bio X Cell The control rat IgG2a monoclonal antibody (RTK2758) was obtained from BioLegend LLC/P29-MitoDsRed cells (5 × 104) or LLC/A11-MitoDsRed cells (1 × 105) were subcutaneously inoculated into C57BL/6J or B6 SCID mice tumours were collected 21 or 42 days after tumour inoculation to collect the TILs for evaluation the mean values of the long and short diameters were used to generate the tumour growth curves When the tumour volume reached approximately 100 mm3 on day 14 anti-PD-1 monoclonal antibody (200 μg per mouse) or control monoclonal antibody was intraperitoneally administered 3 times every 3 days anti-CD8β monoclonal antibody (100 μg per mouse) was intraperitoneally administered 1 day before tumour cell inoculation and then injected every 7 days thereafter was injected locally into the tumours once every 2 days Tumours were collected 42 days after tumour inoculation to collect TILs for evaluation by flow cytometry collected TILs were sorted for DsRed+ cells and cultured for 7 days then evaluated by flow cytometry or mtDNA sequencing we created adoptive T cell transfer models using B6 SCID mice sorted CD8+ T cells (1 × 107) from splenocytes of C57BL/6J or OT-1 mice were transferred into the SCID mice 7 days after tumour inoculation (LLC/P29-OVA-MitoDsRed Tumours were collected 28 days after tumour inoculation to collect TILs for evaluation by flow cytometry MC-38 (1 × 106) or B16F10-OVA (3 × 105) cells were subcutaneously inoculated into Tfamfl/fl mice or Tfamfl/flCd4cre mice and tumour volume was monitored every 3 days The means of the long and short diameters were used to generate the tumour growth curves Anti-PD-1 monoclonal antibody (200 μg per mouse) or control monoclonal antibody was intraperitoneally administered 3 times every 3 days Tumours were collected 14 days after tumour inoculation to collect TILs for evaluation by flow cytometry we performed rechallenge mouse experiments mice that had shown complete eradication of the initial tumours after anti–PD-1 monoclonal antibody treatment were secondarily challenged with parental tumour cells on day 32 LLC/P29-MitoDsRed cells (1 × 105) or LLC/A11-MitoDsRed cells (2 × 105) were subcutaneously inoculated into OT-1 mice DsRed– or DsRed+CD8+ T cells (effector cells) were sorted from TILs and subsequently cocultured with calcein-AM (Thermo Fisher Scientific)-labelled LLC/P29-OVA or LLC/A11-OVA cells (target cells) at the indicated effector-to-target cell ratios LLC/P29 or LLC/A11 cells were used as the controls fluorescence was determined using an excitation/emission filter set of 490/535 nm on an ARVO X3 Multilabel reader (PerkinElmer) Patient characteristics were compared between the two groups using Fisher’s exact tests The relationships between continuous variables between and among groups were compared using a t-test and one-way ANOVA Tumour volume curves were compared using a two-way ANOVA Progression-free survival and overall survival were defined as the time intervals from the initiation of anti-PD-1 monoclonal antibody therapy until the first observation of disease progression or death from any cause Survival curves were analysed using the Kaplan–Meier method and compared among groups using the log-rank test All tests were two-tailed with a predefined significance level of P < 0.05 Statistical analyses were performed using GraphPad Prism 9 (GraphPad Software) The means and standard error of the means (error bars) are shown All in vitro experiments were biologically repeated independently three to four times and produced consistent results All in vivo mouse experiments were conducted with four to six mice per group and were repeated at least twice Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article The data supporting the findings of this study are available from the corresponding authors upon reasonable request. 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capacity and inflammatory status of innate immune cells An oncogenic alteration creates a microenvironment that promotes tumor progression by conferring a metabolic advantage to regulatory T cells jlincbio. jlincbio/mito_somatic_mutect2: release update (v0.3). Zenodo https://doi.org/10.5281/zenodo.12216418 (2024) Download references We thank H. Nagase, E. Tanji and N. Sakurai for their technical assistance. The graphical abstract in Supplementary Fig. 6 was created using BioRender (https://biorender.com) This study was supported by Grants-in-Aid for Scientific Research (Promotion of Joint International Research no Togashi) and Challenging Exploratory Research no Togashi)) and a Grant-in-Aid for Research Fellow (grant no JP22J22286 (to H.I.)) from the Japan Society for the Promotion of Science (JSPS); the Project for Cancer Research and Therapeutic Evolution (P-CREATE Togashi)); Practical Research for Innovative Cancer Control (no Togashi)); the Core Research for Evolutional Science and Technology (CREST Togashi); Practical Research Project for Rare/Intractable Diseases (no JP22ek0109495h0002 (to J.L.)); and Research Program for Hepatitis (no Togashi)) from the Japan Agency for Medical Research and Development (AMED); the Fusion Oriented Research for disruptive Science and Technology (FOREST Ishino)) from the Japan Science and Technology Agency (JST); the National Cancer Center Research and Development Fund (no Togashi)); the Chiba Prefecture Research Grant (to M.K Togashi); the Takeda Science Foundation (to Y Togashi); the Mochida Memorial Foundation (to Y Togashi); the MSD Life Science Foundation (to Y Togashi); the Research Grant of the Princess Takamatsu Cancer Research Fund (no Togashi)); the Kowa Life Science Foundation (to J.N Togashi); the Kato Memorial Bioscience Foundation (to Y Togashi); the Astellas Foundation for Research on Metabolic Disorders (to Y Togashi); the Suzuken Memorial Foundation (to Y Togashi); the SGH Foundation (to J.N.); the Sumitomo Foundation Grant for Basic Science Research Projects (no Togashi)); the Terumo Life Science Foundation (to Y Togashi); the Chugai Foundation for Innovative Drug Discovery Science (to Y Togashi); The Ono Pharmaceutical Foundation for Oncology Togashi); the Kobayashi Foundation for Cancer Research (to M.K Togashi); the Taiju Life Social Welfare Foundation (to J.L.); the 2023 Healthcare Innovation Research Grant established with donations from T Sequencing and bioinformatics analyses were performed on institutional computing resources that included hardware provided by NVIDIA to J.L Department of Otorhinolaryngology/Head and Neck Surgery Chiba University Graduate School of Medicine Department of Allergy and Respiratory Medicine Okayama University Graduate School of Medicine Division of Innovative Cancer Therapeutics Laboratory of Pediatric and Refractory Cancer Department of Dermatology and Plastic Surgery Saitama Medical University International Medical Center Department of General Thoracic Surgery and Endocrinological Surgery Synergy Institute for Futuristic Mucosal Vaccine Research and Development Collection of clinical samples and data: H.I. reviewing and/or revising the manuscript: H.I. All authors read and approved the final manuscript received honoraria from Ono Pharmaceutical Bristol-Myers Squibb and MSD outside this study received honoraria from AstraZeneca outside this study received honoraria from Ono Pharmaceutical and Novartis Pharma outside this study received grants from Janssen Pharmaceutical Pfizer Japan and Ono Pharmaceutical; honoraria from AstraZeneca Eli Lilly Japan and Pfizer Japan outside this study EPS International and Otsuka Pharmaceutical; honoraria from Amgen Taiho Pharmaceutical and Takeda Pharmaceutical; consulting fees from AstraZeneca Takeda Pharmaceutical and Merck Biopharma outside this study Togashi received research grants from KOTAI Biotechnologies Chugai Pharmaceutical and MSD outside this study All other authors declare that they have no competing financial interests Nature thanks Jonathan Brestoff, Nicola Vannini and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations One-way ANOVA with Bonferroni correction were used in (f)-(h) Source Data a and b, DsRed expression and mtDNA mutations in sorted T cells from mouse TILs in vitro. We sorted mitochondria-transferred DsRed+ T cells from LLC/A11-MitoDsRed tumours as described in Supplementary Fig. 3 which were subsequently cultured further in vitro for 7 days We analysed DsRed expression and mtDNA in bulk T cells at each time point and summary of DsRed expression (a) and representative capillary sequencing chromatograms (b) are shown Mitochondrial quantification of LLC/A11 cells transferred from mouse T cells OVA-overexpressing LLC/A11 cells were cocultured with or without CD8+ T cells from PhaMexcisedOT-1 mice for 3 days Dendra2 (green) expression in OVA-overexpressing LLC/A11 cells were analysed using flow cytometry Original mitochondrial quantification of LLC/A11 (d) and MEL04 (e) cells after coculture with mouse T cells and TIL04_#9 cells MitoTracker Green-labelled OVA-overexpressing LLC/A11 or MEL04 cells were cocultured with or without CD8+ T cells from OT-1 mice or TIL04_#9 cells for 3 days OVA-overexpressing LLC/A11 or MEL04 cells were subsequently analysed using flow cytometry Representative flow cytometric staining (e EVs were extracted and purified from the supernatants from which EV-conjugated beads were created The beads were analysed using flow cytometry EV-free medium without any cells was used as a negative control Representative flow cytometric staining is shown Mitochondrial quantification of TIL04_#9 cells transferred from MEL04 cells with NAC TIL04_#9 cells were cocultured with MEL04-MitoDsRed cells and/or NAC for 3 days and then DsRed expression in TILs were analysed using flow cytometry and USP35 from TCGA datasets in patients with melanoma Cells were stained with AF546-conjugated anti-USP30 mAb and analysed using a confocal laser microscope or flow cytometry Representative confocal microscopic images (left) and MFI summary (right) are shown (n = 4 per group) Membrane potential evaluated by MitoTracker Deep Red and Green (j) cellular ROS production evaluated by DCFDA (k) and PD-1 expression (m) in TILs treated with a USP30 inhibitor (CMPD-39) or siRNAs for USP30 TIL04_#9 cells were cocultured with MEL04 cells with or without CMPD-39 or siRNA transfection for 14 days and then analysed using flow cytometry TILs were stimulated with anti-CD3 and anti-CD28 mAbs and (g) and one-way ANOVA with Bonferroni correction were used in (a) and (i)-(m) Source Data Metabolic evaluation using a flux analyser The oxygen consumption rate (OCR; d) and extracellular acidification rate (ECAR; e) were measured under basal conditions and the bioenergetic profile captured the major ATP-producing pathways of each cell line by calculating the ATP production rate (f) We used activity buffer with the isolated mitochondrial protein in place of the supplied mitochondria in the MitoCheck Activity Assay Kits Reactions were conducted at 25 °C using a microplate reader with readings taken every 30 s for 15 min and the absorbance changes from the base line were evaluated Summaries of fold changes to wild-type cells (g Frequencies of CCR7hiCD45RAlo central memory (j) and KLRG1lo long-lived (k) fractions in PBLs Sorted CCR7hiCD45RAhiCD8+ naïve T cells from PBLs of healthy donors were cocultured with MEL02-MitoDsRed or MEL04-MitoDsRed cells for 7 days while being stimulated with anti-CD3 mAb in the presence of IL-7 Apoptosis evaluated by Annexin V in each T cell fraction CCR7loCD45RAlo; terminally differentiated effector memory [TEMRA] CCR7loCD45RAhi) sorted from PBLs of healthy donors was cocultured with MEL02-MitoDsRed or MEL04-MitoDsRed cells for 4 days and apoptosis in DsRed+CD8+ T cells was analysed using flow cytometry Two-sided t-tests were used in (d)-(i) and (l) and one-way ANOVA with Bonferroni correction were used in (j)-(k) Source Data We established DsRed−TIL04#9/MCF7 (wild-type), DsRed+TIL04#9/MCF7 (wild-type), DsRed−TIL04#9/MDA (wild-type), DsRed+TIL04#9/MDA (mutated), DsRed−TILc03#5/02 (wild-type), DsRed+TILc03#5/02 (wild-type), DsRed−TILc03#5/c03 (wild-type), DsRed+TILc03#5/c03 cells (mutated), as described in Supplementary Fig. 4 Membrane potential evaluated by MitoTracker Deep Red and Green (a) cellular ROS production evaluated by DCFDA (b) frequency of CD27−CD28− senescent fraction (f) rapidly dividing cells evaluated by CFSE dilution (g) frequencies of CCR7hiCD45RAlo central memory (i) and KLRG1lo long-lived (j) fractions and PD-1 (k) and CD69 (l) expression in TIL04_#9 cells Rapidly dividing cells were counted after the third division on day 3 Cellular ROS production evaluated by DCFDA (m) and PD-1 expression (p) in TILc03_#5 cells One-way ANOVA with Bonferroni correction were used in (a)-(p) Source Data Two-sided t-tests were used in (a) and (c)-(m) for statistical analyses Source Data We established mtDNA-deficient Jurkat/Rho0, Rho+MEL02-EV (wild-type), and Rho+MEL04-EV cells (mutated), as described in Supplementary Fig. 4 mtDNA amounts and the quantification in Jurkat cells and Rho+MEL04-EV cells was extracted and amplified by PCR using primers specific for the D-loop region and ND5 LINE1 was used as an internal control for nuclear DNA The quantification was performed by real-time PCR and the fold changes to parental Jurkat cells were calculated The representative PCR bands (left) and summary of the fold changes (right) are shown (n = 4 per group) The mtDNA of Rho+MEL02-EV and Rho+MEL04-EV cells was sequenced Representative capillary sequencing chromatograms are shown Rho+MEL02-EV and Rho+MEL04-EV cells were analysed using flow cytometry with TMRE Metabolic evaluation of Jurkat cells using a flux analyser The OCR (d) and ECAR (e) were measured under basal conditions and the bioenergetic profile captured the major ATP-producing pathways of Jurkat cells by calculating the ATP production rate (f) Cellular ROS production evaluated by DCFDA (g) rapidly dividing cells evaluated by CFSE dilution (i) frequencies of CCR7hiCD45RAlo central memory (k) and KLRG1lo long-lived (l) fractions To analyse cell division and PD-1 expression the Jurkat cells were stimulated with anti-CD3 and anti-CD28 mAbs The Jurkat cells were analysed using flow cytometry Two-sided t-tests were used in (a) and (c)-(m) Source Data Source Data Source Data The proportion of total 158 mtDNA variants (a) and 110 mtDNA variant spectra for substitutions on the light (L) or heavy (H) strand (c) in cohorts B and C1/2 Whole mtDNA sequencing for FFPE tumour tissues was conducted with a next-generation sequencing Survival curves of patients who received PD-1 blockade therapy (d 86) and those with NSCLC who received platinum-doublet chemotherapies without any ICIs as first-line therapy (n = 56) according to mtDNA status mtDNA mutations were defined as truncating and missense PFS (left) and OS (right) were defined as the time intervals from the initiation of treatment until the first observation of disease progression or death from any cause Survival curves were analysed using the Kaplan-Meier method and compared among groups using the two-sided log-rank test in (d) and (e) Source Data Download citation DOI: https://doi.org/10.1038/s41586-024-08439-0 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Cancer newsletter — what matters in cancer research This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page This jury will be presided over by Paul Hunter The jury will be comprised of 12 leading experts from eight countries – spanning North America This carefully selected ensemble of jurors will be onsite to see every piece of work before entering into final discussions to decide the statue winners the jury will be very particular in awarding work – work that stands out for its craft that inspires talent and raises the creative bar said: “I’m honored to serve as one of LIA’s 2025 Jury Presidents This show brings together some of the most brilliant creative minds from around the world and I’m excited to see how they continue to push boundaries and redefine what’s possible I’m hopeful about a future where bold ideas and diverse voices shape the next generation of storytelling.” The executive team of PRETTYBIRD includes Paul Hunter Their collective industry experience contributes to PRETTYBIRD’s reputation as one of the most inclusive global creative communities in the entertainment industry PRETTYBIRD was named Ad Age’s Production Company of the Year they were named LIA’s Global Production Company of the Year “We always look to the best in their field to be on our jury We are proud to have Paul Hunter of PRETTYBIRD a company known for creating cutting-edge work that lives at the intersection of branded entertainment as Jury President,” stated Barbara Levy “It is a great responsibility to raise creative standards year after year who are all very well respected in their professions for giving us their time to reward work that is outstanding.” The LIA Entry System is open – all entries finalized and paid by 10th June 2025 will receive a 25% entry discount For more information on the juries, categories and/or requirements, click here. and website in this browser for the next time I comment Register for Free and receive the Campaign Brief Daily Bulletin Type your email address in the space below The athletics watchdog said a disciplinary and appeals tribunal ruled that the 26-year-old Ikeda had broken anti-doping rules Ikeda has been provisionally banned from competition since November 2024 with his results disqualified since June 2023 Doping authorities say abnormalities were detected in his blood samples taken in June The AIU alleged the abnormalities "were indicative of blood manipulation." Ikeda won silver at the Tokyo Olympics in 2021 and silver at the 2022 world championships poses during the medal ceremony for the men’s 20km race walk at the 2020 Summer Olympics MONACO (AP) — Japanese race walker Koki Ikeda The athletics watchdog said that a disciplinary and appeals tribunal ruled that the 26-year-old Ikeda had broken anti-doping rules The AIU alleged the abnormalities “were indicative of blood manipulation.” Ikeda won silver at the 2012 Tokyo Olympics and silver at the 2022 world championships 2025 (GLOBE NEWSWIRE) -- Yoshiharu Ikeda to take up the new role as CEOAndreas Weinhengst and Karl Purkarthofer appointed new CFO and COO respectivelyChanges to become effective on April 1 2025   Primetals Technologies today announced Yoshiharu Ikeda has been appointed to the position of Chief Executive Officer (CEO) of Primetals Technologies who will continue to serve as a Director of the Board and Fellow Advisor Yoshiharu Ikeda brings decades of experience in the metals industry to his role and he has a track record of successful leadership in commercial and strategical roles as well as in the machinery business sector “Yoshiharu Ikeda has spent decades advancing organizations within the Mitsubishi Heavy Industries Group and we are thrilled to welcome him as new CEO of Primetals Technologies,” says Satoru Iijima “He is an exceptional leader who will support our vision of being the pioneer and global leader in the metals industry.” Yoshiharu Ikeda started his career at Mitsubishi Heavy Industries in the mid-80s’ and has held several global positions including Manager Global Sales for Mitsubishi-Hitachi Metals Machinery and CEO of Primetals Technologies USA He is currently Chief Financial Officer (CFO) at Primetals Technologies “The metals industry is in an interesting and at the same time challenging phase Working with customers in every corner of the globe our role is to innovate the industry and redefine how sustainable metals are produced This does not only apply to the upstream area and projects like HYFOR and Smelter – but also the downstream area the electrification of furnaces in rolling mills and processing lines and our ground-breaking Arvedi ESP technology digitalization is an essential part of our innovation efforts We are innovating within the fields of digital decarbonization and process optimization – just to mention a few areas,” says Yoshiharu Ikeda “Primetals Technologies is an international community of more than 7,000 metals engineers and specialists and I really look forward to being part of this endeavor.” CFO of Primetals Technologies Austria since 2018 He has worked within the metals industry since the early 90’s in different leadership positions in commercial sales His job experience includes roles as Commercial Head M&A of Kvaerner Metals Business at Voest-Alpine Industrieanlagenbau and Head of Accounting and Controlling at Siemens VAI Metals Technologies the predecessor company of Primetals Technologies Also effective with Primetals Technologies’ new financial year is the appointment of Karl Purkarthofer in the newly established role of Chief Operating Officer (COO) of Primetals Technologies The responsibility for individual projects remains with the respective business areas Karl Purkarthofer brings several decades of international experience from global leadership positions he held in Austria including Senior Vice President and Head of Strategy and M&A at Siemens VAI and Executive Vice President and Head of Global Business Unit Services at Primetals Technologies Karl Purkarthofer became CEO of Primetals Technologies Austria a position he will continue to hold going forward Please enable JS and disable any ad blocker Waka Ikeda is a Tokyo-based freelance journalist who writes for Nikkei Asia She has been covering Hungary’s unique family policy strategy for several years Konohana recently visited Hungary to gain deeper insight into these initiatives as part of her research for an upcoming book on Japanese and Hungarian family policies She sat down with Hungarian Conservative to discuss Japan’s increasingly urgent demographic crisis and explore potential solutions The main purpose of your visit to Hungary is to gain a deeper understanding of Hungarian family policy what are the main differences compared to those in Japan I’ve actually been writing about Hungary’s family policies for about a year and a half I’ve published around eight articles in The Japan Times I find Hungarian family policy fascinating mainly because it’s so different from Japan’s The areas where the Japanese government falls short include but are not exclusive to: youth support Japan’s family policy only includes limited child support monthly child allowance is around 15,000 yen which is approximately 37,000 forints per child it doubles—but people won’t decide to have a baby just for a small amount of money In contrast, Hungary exempts people under the age of 25 from income tax I love most of the measures I’ve seen here especially those focusing on young people and grandparents Hungary even offers maternity and parental leave for grandparents which I found very unique—I’ve never heard of that in any other country However, there are also some distinct Japanese initiatives, such as the four-day workweek policy announced by the government last December.. but I want to clarify that it hasn’t been codified into law The government is just encouraging companies to try it They are starting a pilot in April this year for national public servants and some municipalities and city halls might follow later probably starting with Tokyo since everything tends to begin there and Sagawa Takkyubin—a logistics company—have begun implementing it employees who work four days a week get paid less than those who work five people with two jobs might switch to four-day workweeks but are forced to work longer hours or more overtime to make up for the lost income So it basically means that the initiative hasn’t served its intended purpose of improving work-life balance Unless the government mandates that employees working four days should still receive full pay Especially with the current labour shortage in Japan I doubt many businesses would adopt this voluntarily—and only large companies might even be able to afford it What could be the broader reasons behind these differences between the Japanese and the Hungarian approach I think it’s mainly political and demographic Japan has what I call a ‘silver democracy’—most voters are over 65 Because of the imbalance in political representation—especially the lack of women in decision-making roles—policy is skewed toward older people Tax revenues are primarily allocated to benefit the elderly not to support youth or make education more affordable Tokyo recently introduced subsidies of around 3,000 euro per year so that many students can attend high school for free But Tokyo is exceptionally wealthy; this isn’t the national norm The political class knows that the elderly are living comfortably at the expense of younger generations Politicians even acknowledge this privately saying that “they are stealing the future of the youth.” As a result little or nothing is done to change the status quo ‘Intense academic pressure hinders social development There are also social and cultural reasons I’ve written about this in Nikkei Asia recently—East Asian societies are deeply rooted in academic credentialism Your university determines the rest of your life That means children must start preparing for elite schools very early Around 40 per cent of elementary school students attend after-school cram schools This intense academic pressure hinders social development many young Japanese lack meaningful human connection There are even restaurants designed for people to dine alone in booths with partitions Many young people today prefer solitude over social interaction That’s a major difference compared to Hungary So reversing demographic decline in Japan would require a complete societal shift Japan needs to stop viewing children as an economic or psychological burden and start seeing them as a value But changing this mindset is extremely difficult One thing I found interesting in Hungary is the ‘family value’ education programmes Hungary promotes human connection and even sex positivity in its educational programmes It focuses only on risks like STDs and sexual violence—there’s nothing about relationships I think Japan could benefit from something broader—not necessarily called ‘sex education’ or ‘family policy’—but rather ‘human education’ that includes gender equality Japan has one of the worst gender pay gaps in the developed world: 21 per cent South Korea is worse at around 30 per cent You mentioned that a lack of social interaction is becoming a serious issue in Japan But we’ve seen similar problems in Western societies too When did this trend start to appear in Japan During the 1980s Japan’s economy was still strong society became more conservative in terms of avoiding risks Marriage became more of an economic partnership than a romantic one we became a democracy and saw strong economic growth until the bubble burst in the late 80s That’s similar to what’s happening in South Korea now—after the 1997 Asian financial crisis Parents tell their children to find a stable job Social media has also made people more insecure That adds another layer to the isolation we’re seeing among young people how do you think this mindset could be changed But Japan has shown it can transform—it went from a feudal society to a militaristic one We achieved rapid economic development in just a few decades we must abandon academic credentialism and embrace individual needs in terms of one-size-fits-all life trajectory: graduate university We need to provide education on gender equality and human rights—not to impose family values Corporate culture also needs a massive overhaul and employees rely on overtime pay to make ends meet We also have a two-track employment system: general administrative positions (mostly filled by women) and professional track jobs (usually given to men) where you work determines your salary—not your job title I'll share my personal experience: I worked in New York for nine years in marketing but when I returned to Japan because of my then-husband’s relocation and employers asked: ‘Who will take care of your child?’ They didn’t say I was too old directly—but the implication was clear If the current demographic trends continue The worst-case scenario is already being projected By 2050 we’re expected to lose 30 per cent of it you’ll already see it—there are barely any buses Even with the current tourism boom due to the weak yen there aren’t enough people to support it—hotels ‘Japanese society doesn’t value young people enough’ I’m always amazed by how many young people are in important positions or leading organizations where seniority and relationships established over decades is prioritized youth Japanese society doesn’t value young people enough it’s a rational decision not to marry or have children Japan is a ‘one-shot society’—you don’t get second chances Many Japanese politicians blame women for not having children but women are fertile—Japanese society is not fertile for having families Could you share some insights with us regarding its main focus and what motivated you to begin this project The working title is A Country Where Young People Want to Have Children vs I’ve met dozens of university students who all said they want to get married and have children most young people I speak with hesitate even to think about marriage The contrast is striking—and it’s one of the main reasons I wanted to explore why Hungary feels so different in this regard Hungary and Japan are similar—not in their family policies and in the fact that most children are born within marriage we can’t just copy policies from Sweden or France—our politicians tend to do it regardless— The similarities in values make that comparison more meaningful Hungarian Conservative is a quarterly magazine on contemporary political philosophical and cultural issues from a conservative perspective Acura's Chief Brand Officer Jon Ikeda on the future of Acura & electrification Subscribe to our newsletters to get the latest in car news and have editor curated stories sent directly to your inbox a prominent Clinical Research Organization (CRO) well-known for its expertise in the areas of in vitro diagnostics (IVDs) and medical devices proudly announces the addition of David Ikeda as senior regulatory affairs strategist Ikeda joins CovarsaDx's team of experts to enhance regulatory strategy and clinical operations for sponsors navigating the complex and evolving global regulatory landscape With over 35 years of experience in medical devices and IVDs Ikeda brings exceptional knowledge and leadership to the organization "David's extensive experience in regulatory affairs and his proven success with FDA and European Union (EU) in vitro diagnostic regulation (IVDR) submissions make him an invaluable asset to our team," said Chermaen Lindberg "His knowledge and leadership will help our clients navigate the regulatory landscape ensuring their products reach patients as quickly and efficiently as possible." Ikeda most recently served as senior staff/principal of regulatory affairs at Beckman Coulter where he spearheaded global regulatory functions supporting the blood virus program development team he held leadership roles at ARKRAY USA and DiaSorin His extensive background spans product quality Ikeda has played an instrumental role in launching products through clinical trials His achievements include bringing blood virus and infectious disease tests to worldwide markets along with significant contributions to therapeutic areas such as bone and mineral metabolism "I'm thrilled to join the team at CovarsaDx," said Ikeda "It's clear they're dedicated to helping bring important medical innovations to market a mission I'm truly passionate about supporting and help our clients navigate the regulatory process successfully." Ikeda's expertise includes FDA and EU submissions for the IVD industry His proven track record of success strengthens CovarsaDx's ability to guide clients through complex regulatory pathways and deliver reliable results "Navigating regulatory pathways requires both deep expertise and a strategic mindset," said Marielle Lejcher vice president of regulatory affairs at CovarsaDx and his addition to our team strengthens our ability to support clients through every stage of the submission process." About CovarsaDxCovarsaDx is a prominent Clinical Research Organization (CRO) specializing in the areas of in vitro diagnostics (IVDs) and medical devices The company provides agile responses to patient population needs and fluctuations in regulatory requirements for rapid market pathways and clinical experts have extensive industry experience and consist of regulatory strategists and statisticians who work together to deliver reliable clinical results enabling clients to bring life-saving technologies to market efficiently Media: [email protected]Study Inquiries: [email protected] CovarsaDx® is a registered trademark of CovarsaDx Corporation a prominent Clinical Research Organization (CRO) renowned for its expertise in the areas of in-vitro diagnostics (IVDs) and medical.. a prominent Clinical Research Organization (CRO) renowned for its in vitro diagnostics (IVDs) and medical device expertise Health Care & Hospitals Medical Pharmaceuticals Medical Equipment Personnel Announcements Do not sell or share my personal information: « Back Tokyo Olympic silver medal-winning race walker Koki Ikeda has been provisionally suspended for "use of a prohibited substance/method," track and field's doping watchdog said Friday achieved the best-ever Olympic result by a Japanese race walker when he finished second in the men's 20-kilometer event at the Tokyo Games in 2021 The Shizuoka Prefecture native was runner-up again at the 2022 world championships and placed seventh at the Paris Olympics this past summer The Associated Press reported Ikeda received the provisional ban for "suspected blood doping," quoting the Monaco-based Athletics Integrity Unit Ikeda was notified of a charge based on suspicious readings in his biological passport The passport can give indications of doping over time without an athlete testing positive for a banned drug The AIU is an independent monitoring division at World Athletics tasked with combating doping and other misconduct in the sport Olympics: Japan's 1st 110-meter hurdle finalist Muratake finishes 5th Paris Olympics latest: Aug. 1, 2024 Olympics: Japan's Koki Ikeda "not strong enough" in 20-km walk To have the latest news and stories delivered to your inbox Simply enter your email address below and an email will be sent through which to complete your subscription Please check your inbox for a confirmation email Thank you for reaching out to us.We will get back to you as soon as possible The Kansas State Veterinary Diagnostic Laboratory (KSVDL) is urging livestock producers to remain alert for a new red blood cell parasite recently diagnosed in calves imported to Kansas This parasite causes anemia and other serious health issues in cattle While it has been present in the eastern U.S it was only recently detected in Kansas after affected calves were brought in for feeding from the east The disease spreads primarily through multi-use needles and insects with the Asian longhorned tick identified as the main vector and a county in northwestern Oklahoma bordering Labette County in Kansas the environmental conditions in eastern Kansas are suitable for the Asian longhorned tick Cattle infected with Theileria orientalis Ikeda may show symptoms such as anorexia KSVDL advises producers to be cautious when importing cattle especially from regions where the parasite has been identified and a webinar on the parasite is available on the KSVDL YouTube channel Producers seeking guidance can contact KSVDL Client Care at 866-512-5650 Ikeda was second in the 20-kilometer event at the Tokyo Olympics in 2021 and placed seventh at the Paris Olympics three months ago The 26-year-old walker was notified of a charge based on suspect readings in his biological passport The passport can indicate markers of doping over time without an athlete testing positive for a banned drug The investigators gave no timetable for the disciplinary case Ikeda also took silver at the 2022 world championships in Eugene Investigative stories and local news updates Coverage of the Hawaiʻi State legislature in 2025 Award winning in-depth reports and featured on-going series Get the week’s news delivered straight to your inbox “We should promote our local products crafts and natural resources such as energy from sun Civil Beat asked candidates to answer some questions about where they stand on various issues and what their priorities will be if elected The following came from Ikeda Rahman Perreira, Democratic candidate for state House District 35, which covers portions of Pearl City and Waipahu, and Crestview. His primary opponents are Cory Chun and Domineque Bonifacio Go to Civil Beat’s Election Guide for general information, and check out other candidates on the Primary Election Ballot What is the biggest issue facing your district Our district is very diverse and there are specific issues to each area in Waikele loud vehicle noise late at night have remained the same or gotten worse homelessness and crime are common complaints homelessness in certain areas as well as high property tax and high property insurance speeding and high property taxes are major complaints These are only few among several other issues high property taxes and high property insurance rates are very often a strong complaint.  I will introduce bills with the consent and help of the respective community to resolve each issue related to each area.  How do you feel about the massive income tax cut just approved by the Legislature and the governor Do you have any concerns that it will force reductions in state services in the years to come I support the income tax cut as it will empower people to have more money to meet the high cost of living in Hawaii In addition we need to reduce the property tax which in turn will reduce the rents.  transparency and getting rid of duplication and waste We should make it easier for small and large businesses to do business and let them prosper which in turn will contribute to a booming economy in the long run.  Hawaii continues to struggle with pay-to-play politics and corruption in government What meaningful reforms do you think would change state government for the better We should have laws or administrative rules to have quarterly or yearly job performances of all the employees to a certain standard Ethical education and training should be mandatory for all government employees just like it is done at Veterans Administration hospitals and other related facilities fines and other strict consequences for noncompliance.  There should be term limits for the state House and Senate just like governor This will help legislators to do their job more efficiently instead of catering to special interest groups for donations.  reducing waste and making sure there is a balanced budget every year.   Candidates often say they will support reform proposals in the Legislature And yet major reform proposals don’t pass Will you back good-government proposals even if it means going against leadership can you point to an example of a reform that you supported Even if the bill passes through different state House and Senate committees I strongly believe that if the creator of the bill talks to colleagues and leadership in advance I was responsible to work on a bill with Rep John Mizuno to give tax breaks to those health care providers who accept Medicaid and Medicare It was well-supported but It did not pass last session it did pass this session with modification It is a good bill but it still needs work to make it better.  Do you support comprehensive public financing of elections for candidates who choose to participate It gives control to public to make legislators responsible and accountable Hawaii is the only Western state without a statewide citizens initiative process I support statewide citizen initiative process and referendum by people People elect legislators and should have the power to make or reject laws enacted by legislators which they collectively or by majority feel are not good for the society.   Thanks to their campaign war chests and name familiarity incumbents are almost always reelected in Hawaii legislative races Should there be term limits for state legislators as there are for the governor’s office and county councils there should be term limits for legislators to reduce corruption or favoritism as I mentioned above in question No What will you do to ensure accountability at the Legislature Do you support ideas such as requiring the Sunshine Law to apply to the Legislature or banning campaign contributions during session I strongly support the idea of no contributions or any promise to contribute during session Laws should always be passed for the good of the people and society instead of special interest groups.  How would you make the Legislature more transparent and accessible to the public Opening conference committees to the public Stricter disclosure requirements on lobbying and lobbyists How could the Legislature change its own internal rules to be more open all the above are necessary especially in light of what happened couple years ago openness and accountability in Legislature to gain back public trust.  Many people have talked about diversifying the local economy for many years now and yet Hawaii is still heavily reliant on tourism should be done differently about tourism and the economy Tourism is important for Hawaii as it is a major source of income and jobs We should promote tourism but there should also be other things to rely on We have already learned the hard lessons after 9/11 and during the Covid pandemic.  We should make it easier to operate small and large businesses and reduce unnecessary regulations and duplication of requirements.  Most important is that legislators should act upon quickly what they promise to do.  An estimated 60% of Hawaii residents are struggling to get by a problem that reaches far beyond low-income and into the middle class What ideas do you have to help the middle class and working families who are finding it hard to continue to live here people of Hawaii are struggling due to multiple factors rising crimes and theft and work force shortages as the working class continue to migrate to the mainland We must make it easier for people in Hawaii live here comfortably reducing taxes including property taxes and increasing government efficiency and transparency we must make it easier for small and large businesses to do business and create more jobs support local products and craft and rely on alternate energy.  we need to increase the salaries and benefits of our good teachers and supporting staff to retain them We need to have a world-class educational system to produce the leaders of tomorrow Unfortunately, being named a finalist for a Pulitzer prize doesn’t make us immune to financial pressures. The fact is, our revenue hasn’t kept pace with our need to grow, and we need your help Civil Beat is a nonprofit, reader-supported newsroom based in Hawaiʻi. We’re looking to build a more resilient, diverse and deeply impactful media landscape, and we hope you’ll help by supporting our essential journalism Civil Beat has been named the best overall news site in Hawaii for the 14th year in a row by the Society of Professional Journalists Hawaii Chapter Recent ‘Best in Show’ winner at Catalina Festival of Art It was a chance encounter that eventually led to Linda Ikeda’s “Best in Show” win at the recent Catalina Island Festival of Art The Islander recently caught up with Linda to find out more about her and her work The winning art piece combines photography and painting two of the many mediums with which Linda likes to work She was a graphic designer and commercial photographer early in her career she focuses more on her creative art works It is what she calls the third act of her life having graduated college with a nursing degree and working in that field in her 20s In terms of the award winning piece at this year’s festival She was swimming regularly at a Long Beach pool for exercise The woman in the piece was also there regularly whom she found out was swimming to try and lose some weight Linda thought she’d make a good photography model and convinced her to let her take some photos Linda had worked in underwater photography during her commercial work so she wouldn’t know what she had until it was developed I wasn’t expecting much out of it,” Linda said but had a large skylight with plenty of light pouring onto the water The photo itself was published in a photography magazine at the time it has also been recognized by the Catalina Art Association Linda lives in Long Beach with her husband They visit Catalina about five times a year Log in to leave a comment Art director Shigemi Ikeda (池田繁美) passed away on October 13, 2024, according to a post made by his family on his X (formerly Twitter) account on October 26. He was 69 years old. Shigemi Ikeda was born on November 5, 1954, in Shinjuku, Tokyo. He joined the industry in the mid-1970s as a background artist at studio Ad Cosmo. He later worked at Group TAC and then Studio Uni, the latter of which is where he debuted as an art director on the 1981 Toei Animation series Beast King GoLion. Recently, Ikeda has been the co-art director for every animated iteration of My Hero Academia since its first season alongside co-Atelier Musa art director Yukiko Maruyama, as well as the art director for Overlord since its first season.Featured image:Inuyasha, © Rumiko Takahashi, Shogakukan, Yomiuri TV, Sunrise 2000Planetes, ©Makoto Yukimura, Kodansha/SUNRISE, BV, NEP,Turn A Gundam, ©Sotsu, SunriseOne Punch Man, © ONE, Yusuke Murata / SHUEISHA, Hero Association HQ Your Ads Privacy ChoicesIMDb Ashley revisits HPR's Tuesday Student Takeover she has played through many piano concerti and is preparing the 2nd movement of Mozart Piano Concerto No 20 for a concert with the Oahu Civic Orchestra on December 7th Ikeda adds onto her advice for young musicians and families that she gave last year the background art director for anime like Mobile Suit Gundam Char’s Counterattack and Mobile Suit Gundam Seed Freedom Ikeda’s family made the announcement on his X (formerly Twitter) account on October 26 JST saying that the veteran died on October 13 JST In a reply to the post, Masami Obari (Brave Bang Bravern! director, Fatal Fury: The Motion Picture director and character designer) paid his respects and recalled the positive experience of working with Ikeda on the 1992 Bastard! Obari was a storyboard artist and episode director on the OVA while Ikeda was its background art director Ikeda joined the industry in 1974 and received his first background art director credit in 1980 he founded the background art company Atelier Musa some of Ikeda’s other credits include: as I Expected (background art director)• Rozen Maiden (background art director)• Bayonetta Bloody Fate (background art director)• One-Punch Man (co-background art director)• My Hero Academia (co-background art director)• Overlord: The Sacred Kingdom (co-background art director) Ikeda was honored with the Outstanding Individual Achievement In Animation for his background art director role in Afro Samurai: Resurrection Source: @rgoRcTW1sMPMWBb London's oldest Japanese restaurant seems to be unknown to everyone but A-listers Going Out | Restaurants Sign up for our expert view on everything that’s worth eating I would like to be emailed about offers, event and updates from Evening Standard. Read our privacy notice Discretion and ostentation play at different ends of the pitch, though both draw crowds. In Berkeley Square last week a Maserati drove by sporting a “baby on board” sticker or a literal sign the driver has their priorities in disarray I don’t suppose the driver knows about Ikeda There are probably two reasons for Ikeda’s everyman anonymity with an adornment-free pale cream frontage that’s usually reserved for the sort of boutique that sells candles for the soul and handbags at fifteen grand who until the 1990s refused to let Westerners in instead preferring the endless tabs of overseas business accounts Now suited sorts mix with those with a subtler type of money Inside is the Wiltons of Japanese restaurants here you wouldn’t be surprised if it were the reverse The place to sit is the counter in front of the chefs Steel pans dented from decades of use are jumped between hobs and flashed beneath a scowling grill A reservoir of oil sits with a stillness that only extreme heat brings on Read more: David Ellis reviews Wiltons — Elegance and charm from a lost world Waitresses in kimonos offer the kind of service that is built on as little interruption as possible Explanations can be requested but recitations do not come as standard and while omakase is offered actually they’re happy to leave it up to you Any obvious judgements of aberrant orders are thankfully suppressed I know because I first went with Fallow restaurateur James Robson who did a lot of pointing and waving and no one batted an eyelid The aubergine was as gooey as a rom-com and twice as comforting But that meal doesn’t count as he convinced me to have sake — the selection is apparently very good — and so I woke up the next morning wondering if my Uber had crashed on the way home lunch came a week later: miso soup felt like a tonic to all of life’s ills its goodness soaking into my blood but also travelling into my past and scribbling out the bad bits Nasu dengaku here means aubergine in slices weighting the balance of flavour in favour of the caramel and malt of the sweet miso spread thickly across the top The aubergine itself was as gooey as a rom-com and twice as comforting From chef’s sushi selection came boldly striped salmon delicate sweet shrimp held to its Kansai-style rice with a belt of nori Unusually soft squid had its carved spikes blackened from the torch There was fatty tuna that tasted of French butter and melted the same way and after that I left thinking perhaps it was sushi as good as any I’ve eaten But by then I was patting a belly full of unaju Places like this usually come with titanic bills and the corresponding sinking feeling. True, wine is mostly marked up in a way that’s only favourable to the restaurant — though eccentrically, Dom Perignon 2009 is cheaper here than online — but Ikeda can be done carefully; we left at £175, preferring it to £420-a-head Sushi Kanesaka. In that sense, it felt like good value — those seeking a blow-out could easily triple the bill. Michelin should visit Meal for two anywhere from about £180. 30 Brook Street, W1K 5DJ, ikedarestaurant.com David Ellis reviews 27 Old Compton Street: the Spirit of Little Italy lives on at this £10 pasta joint David Ellis reviews La Palombe: Sweet dreams are cooked like these Prince Louis steals the show at VE Day parade as he keeps dad William looking sharp and mimics brother George Prince Louis steals show with sweet antics at VE parade Ukraine 'launches stunning Kursk offensive' in major blow for Putin ahead of Victory Day celebrations Ukraine 'launches stunning Kursk offensive' in blow for Putin VE Day 2025 fashion: best looks from the day VE Day 2025 fashion: Princess of Wales to Lady Victoria Starmer New visa crackdown as Home Office plans to restrict applications from nationalities most likely to overstay New visa crackdown as Home Office plans to restrict applications Rihanna shows off baby bump at star-studded Met Gala 2025 as singer's third pregnancy with A$AP Rocky announced Rihanna debuts baby bump on star-studded Met Gala blue carpet Pioneering artist and composer Ryoji Ikeda takes center stage for the first time performing his Ultratonics album live on a tour across the country that also sees dates in Fukuoka and Hokkaido The performance will see live sound along with matching visuals His request for fans to send him letters has been heavily criticized online who rose to fame as Gokai Silver in the 2011 television series Kaizoku Sentai Gokaiger was arrested for defrauding a man in his 60s he allegedly persuaded the man to part with his three cash cards after posing as a police officer He was then arrested again the following month for withdrawing ¥1.5 million from the victim’s bank accounts Ikeda’s contract with his agency was terminated and his voice was removed from the anime shows, Ensemble Stars! and The Kingdoms of Ruin. Earlier this month he was found guilty of fraud and sentenced to three years in prison.   Following the conclusion of his trial, a letter written by Ikeda was posted on his X page There is the ‘truth,’ but ‘legally,’ I was found guilty in court and will be an inmate from now on ‘I’m still waiting for you,’ and ‘I’ll always be your fan.'”  Then came his request: “I know this is a roundabout way of saying it would you be so kind as to write me a letter But please lend me your strength so that I can crawl out of this brink of despair I would like to open the curtain on my second chapter Please give me the motivation to do so.” Ikeda revealed the address of the Tokyo detention house where he’s imprisoned “Visits are also accepted.” Many people criticized the brazenness of his words leading to a follow-up letter on October 22 Ikeda promised fans that despite the adverse reaction he wouldn’t quit and would “keep shouting.” He asked them to continue to show their support and wait for his return He also vowed to do a nationwide “thank you” tour to show appreciation for those who sent him letters.  “As someone who is currently watching Gokaiger every week I feel nothing but discomfort towards Junya Ikeda when I read the news articles He was involved in fraud and received prison time so I think he should wait until he has served his sentence before he speaks out your new go-to podcast to spice up your weekday mornings with relevant news and behind-the-scenes from Brussels and beyond From the economy to the climate and the EU's role in world affairs this talk show sheds light on European affairs and the issues that impact on our daily lives as Europeans Tune in to understand the ins and outs of European politics Dare to imagine the future with business and tech visionaries Deep dive conversations with business leaders Euronews Tech Talks goes beyond discussions to explore the impact of new technologies on our lives the podcast provides valuable insights into the intersection of technology and society Europe's water is under increasing pressure floods are taking their toll on our drinking water Join us on a journey around Europe to see why protecting ecosystems matters and to discover some of the best water solutions an animated explainer series and live debate - find out why Water Matters We give you the latest climate facts from the world’s leading source analyse the trends and explain how our planet is changing We meet the experts on the front line of climate change who explore new strategies to mitigate and adapt As part of the programme celebrating Tartu as a 2024 European Capital of Culture Ryoji Ikeda – who is known for incorporating data and technology into his artworks – opened his solo show at the Estonian National Museum (ENM) in Tartu The exhibition presents two pioneering new works created specifically for Tartu 2024: ‘the critical paths’ (2024) is an audiovisual installation drawing on research by the University of Tartu Institute of Genomics, visualising the DNA of 100,000 Estonians on LED screens while ‘vox aeterna’ (2024) marks Ikeda's debut sound piece featuring the human voice offering a completely new listening experience and created in collaboration with the Estonian Philharmonic Chamber Choir the exhibition features ‘data-verse’ (2019-20) where thousands of technical data points – such as coordinates and DNA sequences – are transformed into captivating visual forms “The genome data of Estonians has inspired an artwork where visitors walk through a stream of data that represents the history of Estonia the stronger the connection between the research which are seen in all ENM exhibitions,” ENM director Kertu Saks said “My work makes up only 50 percent; the other 50 percent is created by the audience – art is a dialogue between me and the viewer allowing them to experience something personal and unique,” Ikeda commented on the exhibition encouraging visitors to bring their own perspectives to the multi-sensory show Ryoji Ikeda’s solo exhibition runs at the Estonian National Museum (ENM) in Tartu until 2 March 2025 On Sunday, Mar. 30, K-1 Japan Group hosted KRUSH 172 The event featured two kickboxing title bouts Manager Futoshi Ikeda has parted ways with the Japan women's national football team upon the expiry of his contract the Japan Football Association said Wednesday The 53-year-old took the reins of Nadeshiko Japan in October 2021 and guided them to the quarterfinals both at the 2023 World Cup in New Zealand where they beat eventual champions Spain 4-0 in the group stage "I wanted Nadeshiko Japan to rise even further and be there with the players myself to witness the scenes lying ahead," Ikeda said on the JFA website as he thanked the players "I believe we managed to increase our output as a team and develop through competing in international tournaments Japan's 2011 World Cup-winning manager and currently the JFA Women's Committee Chairperson said a contract extension beyond August was not on the table with a belief that someone new is required to reach tournaments' later stages "We've begun searching (for Ikeda's successor) and not just in Japan as well as fellow men's J-League outfit Avispa Fukuoka before steering Japan to their first Women's Under-20 World Cup title in 2018 "I hope Nadeshiko Japan continue to play courageously thrilling many people and being a team children dream of," he said JFA President Tsuneyasu Miyamoto thanked Ikeda for his efforts where Japan went out following a 1-0 extra-time defeat to the eventual gold medalists the United States saying he hoped the manager would keep "lending his hand to Japanese football's development." Japan will play an international friendly match against a still-unannounced opponent on Oct Olympics: Japan fall 1-0 to U.S. in women's football quarterfinal Olympics: Japan beat Nigeria, facing U.S. in women's football last 8 Olympics: Tanikawa stunner hands Japan vital win in women's football Ryoji Ikeda continues to push the boundaries of his art he has embraced various opportunities since the pandemic including major solo exhibitions at the Aomori and Hirosaki Brick Warehouse Museums and the release of his reflective album ultratronics These efforts have brought his innovative work to the Japanese public in diverse forms Ikeda will take his unique sound to five cities joined by an exceptional lineup featuring VMO a.k.a Violent Magic Orchestra After several successful showcases of ultratronics in Japan and globally the tour will bring this electrifying experience to life once again beginning with a performance at KT Zepp Yokohama in Kanagawa NiEW Best Music is a playlist featuring artists leading the music scene and offering alternative styles in our rapidly evolving society the NiEW editorial team proudly curates outstanding music that transcends size Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page.