Marques Johnson and Ethan Tribble had interception returns for a touchdown Friday night for the Cimarron-Memorial football team in a 39-7 playoff win over Bonanza It was Cimarron’s first postseason victory since 2009 The Spartans’ six wins are the most for the program since 2013 “The kids are buying into the positivity we have Felix Romero rushed for two touchdowns and Jeremiah Escamilla also scored Cimarron advances to face Somerset Losee — one of the favorites to win the Class 4A state title “Our kids are excited for the challenge,” Kanie said Locally owned and independent since 1950; Winner of the Pulitzer Prize for Public Service best news website in the nation & DuPont Award for broadcast journalism This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page The Future of AI and Buddhist Teachings (Dr 60th Anniversary of Normalization of Japan-South Korea Diplomatic Relations: Pre.. Copyright © 2015- Foreign Press Center Japan Metrics details Planetary stability must be integrated with United Nations targets to fight poverty and secure human well-being Prices may be subject to local taxes which are calculated during checkout The Millennium Development Goals Report 2012 (UN Our Nutrient World (Centre for Ecology and Hydrology Download references David Griggs is professor and director of the Monash Sustainability Institute Mark Stafford-Smith is at the CSIRO Climate Adaptation Flagship Owen Gaffney is in the International Geosphere-Biosphere Programme Öhman are at the Stockholm Resilience Centre Priya Shyamsundar is in the South Asian Network for Development and Environmental Economics Will Steffen is at the Stockholm Resilience Centre and the Fenner School of Environment and Society Gisbert Glaser is at the International Council for Science Norichika Kanie is at the Tokyo Institute of Technology and the United Nations University Institute of Advanced Studies Ian Noble is at the Global Adaptation Institute Reprints and permissions Download citation Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Environmental Monitoring and Assessment (2024) Sign up for the Nature Briefing newsletter — what matters in science Share on FacebookShare on X (formerly Twitter)Share on PinterestShare on LinkedInDAVENPORT Iowa (KWQC) - A 25-year-old Davenport man was arrested Wednesday night following a police pursuit police saw a wanted suspect in the parking lot of La Quinta Inn on East Kimberly Road Police say they tried to take the wanted suspect Kanie Bragg into custody but were unsuccessful Bragg then fled from police in a vehicle according to officials With assistance from the Scott County Sheriff’s Office and Iowa State Patrol officials began a “lengthy vehicle pursuit” throughout central and eastern Davenport Officers and deputies were able to stop the vehicle in the 700 block of Gaines Street where Bragg was taken into custody Detectives are following up on the incident Professor Norichika Kanie Graduate School of Media and Governance The recent spread of COVID-19 has once again drawn attention to the unsustainability of modern society resulting in a domino effect of employee layoffs and corporate bankruptcies A host of related issues have also been identified such as widening income and education disparities discrimination against people with COVID-19 We have also witnessed that those who bear the brunt of these effects are also often the most vulnerable groups in society and include single mothers and temporary workers.So what should we do now Now is the time to rebuild our society with the SDGs as our guide the challenges we face today—dealing with infectious diseases building infrastructure both physical and digital and eradicating poverty—are all clearly outlined in the goals of the SDGs the price we pay for postponing solutions to these longstanding challenges and we cannot afford to put off dealing with these issues any longer.The SDGs represent a common blueprint for the future Despite differences in opinion and methodology the world's ultimate goal remains the same: the faster we respond to the SDGs the faster they can become a source of growth for every country and company on the planet Now that the SDGs have gained a certain level of recognition the next challenge is how to turn them into actionable ways forward a research laboratory and research consortium he founded three years ago conducts research and carries out projects with local and national governments and corporate partners like MUJI His lab's "SDGs Action List for Companies," released in June is a translation of the SDGs into actionable steps that can be used as a tool for corporate evaluation by local governments and financial institutions he plans to publish a set of Post-COVID SDGs which set out how the SDGs should be interpreted in the future.Prof Kanie believes the significance and role of academic institutions lie in their ability to present various indicators and methodologies in a neutral and objective way are a powerful force in achieving the SDGs with their flexible mindsets and ability to take action Their positive 'can-do' attitude is the epitome of the SDG mentality and they don't make excuses for why things can't get done," he says we hope to expand our activities to include more integrated activities where students at Keio's affiliated schools can learn about the SDGs alongside university students." *All affiliations and titles are those at the time of publishing *This article originally appeared in the 2020 autumn edition (No Umeno Sumiyama and Koume Kodama used to joke about beating the previous world record holders Restaurants only provide delivery and pickup Only a few people are allowed into these stores so you can observe very long queues outside the doors We must maintain a distance of 2 meters from other people and can only have gatherings of up to 2 people All sports events and mass events have been canceled or postponed I have heard of very high fines for leaving the house for non-essential reasons Starting on April 16th we are required to wear masks outside the home rollerblading is a big and very important part of my life.Until the pandemic rollerblading was my main mode of transportation and it still is I’ve completely given up public transportation and avoid cities.Now my work is mainly online I try to go out and skate at least 3 times a week to discover interesting places in my area I am glad that I live in a small town outside Warsaw because I can skate far away from people and admire beautiful sunsets I hope they don’t implement a total ban Currently I don’t know what could stop because I want to take advantage of the empty roads Even though I’ve always kept away from the crowds I’ve discovered some beautiful places and everything is so clean and empty I hope that the situation will stabilize as soon as possible and that there will be no more bans Due to the limitation that only two people can meet at a time The majority of skaters do not want to deal with the police I am glad they are not giving up completely and sometimes you can run into another skater while out skating In Poland inline skating is a very popular sport I am sad that the night skate season in Poland has been postponed and that all marathons will now take place only in autumn We had also planned long-distance trips around Poland which I was going to take part of for the first time.We miss the company of our of skaters It’s good that there are so many positive and helpful people in skating.I cordially greet all the skaters out there It will all end soon and we will be able to return to a new life If you enjoy our articles and content at bigwheelblading.com please take a moment and visit our Patreon page. 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About | Affiliate Programs | Contact Two Japanese sisters aged 107 years and 300 days have been certified as the world's oldest living identical twins and the oldest ever recorded Umeno Sumiyama and Koume Kodama had their record recognized surpassing Japanese centenarian celebrity twin sisters Kin Narita and Gin Kanie who held the previous record of 107 years and 175 days Fondly known to the public as Kin-san and Gin-san having appeared on numerous television shows and in commercials the third and fourth of a total of 11 siblings They lived separately after graduating from elementary school but in their 70s began a pilgrimage to the 88 temples on Shikoku Island They have in the past joked about aiming for the record set by Narita and Kanie The sisters reside in separate elderly care homes Sumiyama teared up upon receiving a certificate from staff at the facility a Guinness World Records press release said The number of people aged 100 or above in Japan which has one of the most rapidly aging populations in the world Seniors account for record 29.1% of Japan's population Japan's centenarians hit record 86,500, 10,000-plus men for 1st time 100-year-old Japanese recovers from COVID-19, says positivity is key To have the latest news and stories delivered to your inbox Simply enter your email address below and an email will be sent through which to complete your subscription Please check your inbox for a confirmation email Thank you for reaching out to us.We will get back to you as soon as possible Umeno Sumiyama (left) and Koume Kodama (right) receiving their certificates from Guinness World Records Two sisters in Japan have been declared the world's oldest identical twins Related: Seeing double: 8 fascinating facts about twins They were born on Shōdoshima Island in Japan into a large family Kodama moved to Kyushu in southern Japan to work as a maid The pair rarely saw each other for decades until they turned 70 when they reconnected and started making pilgrimages together — How long can humans live?  —7 ways the mind and body change with age —World's oldest people may have supercharged immune cells Some scientists speculate that lifestyle factors play an important role in the first 80 years of life after which genetic factors become more and more important in keeping a person healthy as they age Get the world’s most fascinating discoveries delivered straight to your inbox Genetic variants that have been linked to longer life spans include variants in the ABO, CDKN2B, APOE and SH2B3 genes, Live Science previously reported These variants have been found to be more common in centenarians than people with average life spans Another recent study found that centenarians may have special gut bacteria that help ward off infections, Live Science previously reported Years of 'confusion and debate' are over — research finds hormone therapy is good for women's hearts in early menopause Silent X chromosome genes 'reawaken' in older females, perhaps boosting brain power, study finds Digital 'resurrection' of the Titanic sheds light on fateful night the ship tore apart Background: Schizophrenia is a disabling illness. Social cognition and interaction training (SCIT) seeks to improve patients’ social functioning by alleviating deficits in social cognition. SCIT has shown promise in improving social cognition in patients with schizophrenia, but has not yet been studied in Japan. Design: An assessor-masked, randomized, parallel-group clinical trial was conducted to compare the feasibility and efficacy of SCIT with treatment as usual (TAU). Setting: Participants were recruited from outpatient clinics at the National Center of Neurology and Psychiatry and four other hospitals in Japan. Participants: Seventy-two patients diagnosed with schizophrenia or schizoaffective disorder consented to participate in the trial. Procedure: Participants were randomly allocated to either a SCIT subgroup or a TAU subgroup. SCIT is a manual-based group intervention that is delivered in 20–24-h-long weekly sessions. Groups include two to three clinicians and four to eight patients. Hypotheses: We hypothesized that SCIT would be found to be feasible and that patients who were randomized to receive SCIT would exhibit improvements in social cognition. Conclusions: In terms of the primary objective, the relatively low dropout rate observed in the present study suggests that SCIT is feasible and well tolerated by patients with schizophrenia in Japan. This view is also supported by participants’ relatively high attendance and intrinsic motivation. Volume 10 - 2019 | https://doi.org/10.3389/fpsyt.2019.00589 This article is part of the Research TopicEmpathy in a Broader Context: Development, Mechanisms, RemediationView all 19 articles Background: Schizophrenia is a disabling illness Social cognition and interaction training (SCIT) seeks to improve patients’ social functioning by alleviating deficits in social cognition SCIT has shown promise in improving social cognition in patients with schizophrenia parallel-group clinical trial was conducted to compare the feasibility and efficacy of SCIT with treatment as usual (TAU) Setting: Participants were recruited from outpatient clinics at the National Center of Neurology and Psychiatry and four other hospitals in Japan Participants: Seventy-two patients diagnosed with schizophrenia or schizoaffective disorder consented to participate in the trial Procedure: Participants were randomly allocated to either a SCIT subgroup or a TAU subgroup SCIT is a manual-based group intervention that is delivered in 20–24-h-long weekly sessions Groups include two to three clinicians and four to eight patients Hypotheses: We hypothesized that SCIT would be found to be feasible and that patients who were randomized to receive SCIT would exhibit improvements in social cognition Results: Data from 32 participants in each subgroup were entered into analyses The persistence rate in the SCIT subgroup was 88.9% Intrinsic motivation was significantly higher in the SCIT subgroup than the TAU group during the first half of the program Mixed effects modeling of various outcome measures revealed no significant interaction between measurement timepoint and group in any measures In the case of the social cognition measure significant change was observed only in the SCIT subgroup; however the interaction between timepoint and group failed to reach significance a shorter duration of illness was found to be associated with significantly better improvement on the social cognition measure in the SCIT subgroup compared with the TAU subgroup Conclusions: In terms of the primary objective the relatively low dropout rate observed in the present study suggests that SCIT is feasible and well tolerated by patients with schizophrenia in Japan This view is also supported by participants’ relatively high attendance and intrinsic motivation improving social cognition may well lead to improvement in social functioning Social cognition and interaction training (SCIT), which was developed by Penn and colleagues, is a program for social cognitive rehabilitation in schizophrenia (12). Compared to other psychosocial interventions that have been designed to target specific social cognitive impairments to the exclusion of other domains (13, 14) SCIT targets a broader range of social cognition SCIT includes training sessions focusing on emotion perception generating alternative interpretations of social situations which are designed to increase flexibility in attributional style and improve metacognition SCIT is theorized to improve social cognition through a combination of rehearsal-based “bottom-up” learning and acquisition of social cognitive strategies that are consciously deployed by patients in social situations patients with enhanced social cognitive skills may show better coping strategies and be better able to gain social support to decrease their level of stress may be less likely to show positive and negative symptoms as SCIT requires the patients to focus attention on facial expression and the social interaction vignettes and also to remember what they learned in each session treatment effects may well generalize from social cognitive to neurocognitive domains we would expect this effect to be small because the program was not any more specific to neurocognition than other treatment programs Although improvements in social functioning positive and negative symptoms and neurocognition would be consistent with the SCIT intervention approach; these are not the primary treatment targets of SCIT we did not formally hypothesize change in these domains in this initial trial Participants were 73 patients treated between August 2013 and July 2017. Sample characteristics are presented in Table 1. Inclusion in the trial required that the patient be at least 20 years old and no more than 65 years old, and that they meet the diagnostic criteria for schizophrenia or schizoaffective disorder specified in the Diagnostic and Statistical Manual of Mental Disorders, fourth edition, text revised (26) Participants were recruited from outpatient clinics at the National Center of Neurology and Psychiatry (NCNP) and Nara Medical University Hospital in Japan All patients were attending psychosocial treatment at least once a week at the time of the study and had the capacity to give written informed consent Table 1 Participants’ sociodemographic and clinical profiles Continuous variables are presented in the form M ± SD Patients were excluded from participation in the study if they presented at screening with serious suicidal ideation or life-threatening, severe, or unstable physical disorders; had a history of substance or alcohol use disorder within 3 months prior to screening; or had an estimated IQ lower than 70, as assessed by the Japanese Adult Reading Test (JART) (27) Patients for whom participation in the study was deemed to be inappropriate by the doctor in charge and/or the investigator for any other reason were also excluded The SCIT-J study was conducted at multiple sites: the NCNP a general hospital specializing in psychiatry and neurology located in the suburbs of Tokyo; Sawa Hospital a psychiatry hospital located in Osaka; Toho University School of Medicine a university hospital located in Tokyo; Inuyama Hospital a psychiatry hospital located in Aichi; and Nara Medical University Seventy-three potential participants were referred to the SCIT-J trial Seventy-two patients consented to participate in the trial and met the enrolment criteria Participants were randomly allocated to either a SCIT subgroup or a treatment as usual (TAU) subgroup in a 1:1 ratio using a computer-generated sequence obtained online Restricted and adapted randomization (i.e. minimization) was used to minimize imbalances in age (30 or older vs no rater was able to access information that could possibly reveal a participant’s subgroup allocation In order to adapt the SCIT program to the Japanese culture and people, the SCIT manual was translated into Japanese with the help of one of the authors (DR), who is one of the developers of SCIT (28) social interaction scenarios used in the program were recreated using Japanese actors Although we did not follow the translation-back translation methodology we received a training and were given supervision from the developers of SCIT and also had multiple sessions of interactive discussion in adapting the program to Japanese culture and understanding paranoia (seven sessions); 2) figuring out situations which consists of distinguishing facts from guesses and avoiding jumping to conclusions (eight sessions); and 3) integration (five to nine sessions) During the study period, the TAU subgroup attended other psychosocial treatment programs other than SCIT and cognitive remediation therapy at least once a week. For all participants, the use of psychotropic medication was not necessarily fixed; rather, it was flexible according to their clinical state. Participants’ antipsychotic medications at baseline are presented in Table 2; mean daily dosage levels (CPZ equiv.) did not differ significantly between the two subgroups We compensated each participant for their time with a payment of 5,000 JPY (approximately 38.8 EUR) at each assessment Table 2 Number of patients prescribed each antipsychotic medication at baseline The study consisted of an assessor-masked, randomized, parallel-group clinical trial that compared the feasibility and efficacy of SCIT in conjunction with TAU to TAU alone. Assessment measures were administered to all patients at baseline (between 4 and 1 weeks prior to the start of the SCIT treatment program), at a 3-month interim assessment (after 12 ± 2 weeks), and at a 6-month endpoint assessment (after 24 ± 2 weeks; Table 3) showing when each measure was administered Ethical approval was obtained for the study (Ethical Committee of the National Centre of Neurology and Psychiatry), and the trial was registered with the University Hospital Medical Information Network (UMIN000011240; URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000013171) and value/usefulness (range: 21–144 higher scores indicate stronger intrinsic motivation level) The Face Emotion Selection Test (FEST) (34) is a measure used to assess emotion perception consisting of 21 photographs of human faces depicting seven different emotions (happiness The photographs of Japanese actors were presented in a random order to the participant the participant selected one of the seven emotions; these were listed below the stimulus photograph and printed in Japanese The score for each emotion was the number of correct responses (range: 0–3) to faces depicting that emotion The total score was the sum of all scores for individual emotions (range: 0–21 higher scores indicate better face emotion perception) In our previous study (34), it was demonstrated that the patients with schizophrenia performed significantly worse on the FEST compared to healthy control subjects. The FEST total score was significantly positively correlated with scores of the Brief Assessment of Cognition in Schizophrenia (35) attention subscale The Hinting Task (33) is a measure assessing ToM and requires participants to infer the real intentions behind indirect speech The task comprised 10 short passages presenting an interaction between two characters in which dialogue produced by one of the characters provided a hint at an underlying message The participant was then asked what the character really meant when s/he uttered the hint If the participant failed to give the correct response depending on whether the extra hint was given The total score was obtained by summing the participant’s scores for each passage (range: 0–20 higher scores indicate better theory of mind capacity) We used the Japanese version of the Hinting task, which was translated and adapted to Japanese language and culture, and its psychometric properties were verified by showing a significant relationship with the SCSQ ToM subscale and also a significant difference between the patients with schizophrenia and healthy controls in our previous study (31) The BACS (35) is a measure assessing neurocognitive function in six cognitive domains: verbal memory, working memory, motor speed, verbal fluency, attention, and executive function. We used the Japanese version of the BACS (36) was standardized by computing z-scores with reference to a distribution in which the mean score of Japanese healthy controls was set at 0 and the standard deviation set at 1 In a validation study of the Japanese version of the BACS, internal consistency was acceptable with Cronbach’s alpha of 0.77 and showed a good construct validity with the composite score being significantly correlated with standard neurocognitive tests in general (36) the Japanese version of the BACS is widely accepted in Japan as a practical scale to evaluate cognitive function In addition to the above measures, the PANSS (38) was used to assess symptom severity and the GAF to assess functioning (39) We used linear mixed effects modeling (conducted using SAS 9.4; SAS Institute Inc. USA) to compare the SCIT and TAU subgroups over time on outcome variables reflecting their social cognition The model included fixed main effects of treatment subgroup (TAU vs and a treatment subgroup × timepoint interaction random effects for participants were included A significant interaction term in such a model would imply a difference in the effect of the intervention between timepoints It was hypothesized that the SCIT subgroup would show significant improvements over time on the SCSQ subscales relative to the TAU subgroup Effect sizes are reported to supplement statistical tests in order to explore predictors of the effect of SCIT on SCSQ total scores a stepwise multiple regression analysis was conducted Improvement in total SCSQ score observed in the SCIT subgroup between the baseline and 6-month endpoint assessments was entered into the analysis as a dependent variable and IMI score (mean) were included as independent variables When significant variables were identified in this analysis the total sample was subdivided according to the median value of these variables and a secondary analysis using linear mixed effects modeling was conducted for the subgroup that was likely to benefit from SCIT treatment including data from all participants who were assessed at least once after any kind of intervention Seventy-three patients were referred to the trial Thirty-six patients were allocated to the SCIT subgroup and 36 to the TAU subgroup four patients in the SCIT subgroup and four patients in the TAU subgroup dropped out before the 3-month interim assessment three in the TAU subgroup left the study before the 6-month endpoint assessment data from 32 SCIT subgroup and 32 TAU subgroup participants were submitted to statistical analyses The SCIT and the TAU subgroups did not differ significantly on any sociodemographic or clinical variables, such as sex, age, duration of illness, daily antipsychotic dosage level, years of education, daily activities, baseline level of symptoms, level of functioning, or IQ as estimated by the JART (Table 1). Average total PANSS scores showed that the patients were generally at a moderate level of symptom severity (40) and nearly half the patients were engaged in competitive work suggesting that the participants in the present study were relatively high-functioning We estimated the feasibility of SCIT by using a) persistence rate at the 6-month endpoint and c) IMI at the interim timepoint and endpoint The persistence rate in the SCIT subgroup was 88.9% (32/36) as only four out of 36 participants dropped out The average attendance rate at SCIT was 87.4% (SD = 15.9) between the baseline assessment and the 3-month interim assessment 86.4% (SD = 18.7) between the 3-month interim assessment and the 6-month endpoint assessment and 87.0% (SD = 14.8) over the entire period IMI scores for the first half of the program (between the baseline and 3-month interim timepoints) were significantly higher in the SCIT subgroup than in the TAU subgroup (P < 0.01) the groups did not differ significantly at end-point analysis The results of the mixed effects modeling revealed no significant interaction between timepoint and group in the total SCSQ score (Table 4). However, significant change was observed between the baseline and 3-month interim assessments, and also between the baseline and 6-month endpoint assessments, only in the SCIT subgroup (Figure 2) Table 4 Results of mixed effects modeling of various outcomes Figure 2 Comparison of changes in total SCSQ score from baseline to the 3-month interim timepoint and the 6-month endpoint Significant change in total SCSQ scores was observed between the baseline and 3-month interim assessments and also between the baseline and 6-month endpoint assessments only in the SCIT subgroup The results of the mixed effects modeling revealed no significant interaction between timepoint and group in any of the outcome measures, including social cognition, symptom severity, neurocognition, and social functioning (Table 4) this indicated that the change in total SCSQ scores between the baseline assessment and both the 3- and 6-month assessments was larger in the SCIT subgroup than in the TAU subgroup among participants with a relatively short duration of illness Table 5 Summary of stepwise multiple regression analysis on improvement in SCSQ total scores during 6 months of treatment with SCIT (dependent variable: change in SCSQ score over this period) and IMI (mean) were entered into the analysis as independent variables Table 6 Exploratory analysis in subgroups with low total SCSQ scores at baseline (≤32) and a short duration of illness (≤149 months) Both values represent the median in the full sample which presented a score of 61.14 ± 16.83 in the schizophrenia remediation sample we found that SCIT appears to be feasible and well tolerated by patients with schizophrenia in Japan as it has been when used with patients from other countries In their review of social cognitive interventions for schizophrenia effect sizes varied from 0.07 to 1.01 across various subdomains of social cognition with a mean level of 0.40 the required sample size would be calculated to be 200 we decided the present study should be focused on feasibility and to generate effect size estimates for a future and the distribution of the data was significantly skewed to the left (Shapiro-Wilk test Further studies incorporating these new techniques are warranted in the future It would be worthwhile to attempt to replicate our exploratory finding that patients with an onset of illness within the last 12 years the program may well have the capacity to prevent functional deterioration The current study has a number of limitations the small sample size may have led to insufficient power to detect differences between the groups on outcome measures although as the first study to test the feasibility of SCIT in Japan we attempted to recruit the patients from a wide population the patients who consented to participate in the study were relatively high functioning despite the moderate level of PANSS scores we could not conclude whether the program could be applied to lower functioning patients we did not account for changes to pharmacotherapy during the treatment period of this study the potential effects of changes in pharmacotherapy on the efficacy assessment cannot be denied subjects’ participation in psychosocial treatments other than SCIT was not controlled the therapeutic durability of training effects was not assessed All these limitations should be taken into consideration in interpreting the efficacy analyses; however none impacts conclusions regarding the feasibility and acceptability of SCIT although this study showed limited benefits for social cognition outcome measures associated with SCIT compared with TAU SCIT is feasible for use with and well tolerated by Japanese patients with schizophrenia in real-world outpatient settings Ethical approval was obtained for the study (Ethical Committee of the National Centre of Neurology and Psychiatry) and the trial was registered with the University Hospital Medical Information Network (UMIN000011240; URL: https://upload.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000013171) and DR were involved in the conceptualization and planning of the study and SO were involved in the implementation of the trial and KN developed the Japanese version of the treatment intervention AKa was responsible for management of the trial including implementation of randomization procedures KN was responsible for the statistical analyses All authors critically reviewed the manuscript and approved the final version This study was supported by a National Center of Neurology and Psychiatry Intramural Research Grant (24–1 27–1) for Neurological and Psychiatric Disorders The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest We would like to acknowledge the assistance of all the staff members in running the SCIT trial at the NCNP, Sawa Hospital, Toho University School of Medicine, Inuyama Hospital, and Nara Medical University. We would also like to thank Dr. Koichi Kaneko and Dr. Tamiko Mogami for translating the SCIT manual. 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Schizophrenia in Japan: A Multicenter Randomized Clinical Trial Received: 28 November 2018; Accepted: 25 July 2019;Published: 23 August 2019 Copyright © 2019 Kanie, Kikuchi, Haga, Tanaka, Ishida, Yorozuya, Matsuda, Morimoto, Fukuoka, Takazawa, Hagiya, Ozawa, Iwata, Ikebuchi, Nemoto, Roberts and Nakagome. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Kazuyuki Nakagome, bmFrYWdvbWVAbmNucC5nby5qcA== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Advanced therapy is now providing patients new hopes for incurable diseases Biopharmaceutical industries are now pouring great effort into the development of cell manufacturing processes for cells as a drug product the development and distribution of a drug product made from a living raw material The success of cell manufacturing depends on how much we can control cell culture Although cell culture has a history of almost 100 years nearly the same as that for gasoline-based cars present cell cultures rely on craftsmanship while cars are massively produced worldwide using automation the safety of cars improved drastically following their maturation in industrial manufacturing we can say that innovation in manufacturing is the key to changing not only availability and cost Our group has been challenged to introduce the advanced engineering technologies to achieve consistent cell manufacturing by the support of AMED (Japan Agency for Medical Research and Development) AMED has been leading the national project (project leader is Professor Masahiro Kino-oka) which is designed to fuse cutting-edge sciences and technologies to innovate cell culture The project’s final goal is to develop an ecosystem to enable successful cell manufacturing for promising advanced therapies This project studies the ‘controllability’ (designated as ‘manufacturability’) of cells from a manufacturing point of view given that bridging academia and industry is extremely important in this field Through the project we have found that there are two things that can change the success rate of cell manufacturing One is simply the introduction of advancing technologies to enhance cell culture automation is the development of  a new mindset for cell manufacturing The mindset that is needed for the future of cell manufacturing is not focused on the beauty of craftsmanship It is rather to restrain oneself with ‘risk-based thinking’; to think continuously about cause and effect Since the gap between lab-scale and industry-scale can be incredibly wide it is never too early for this new mindset to be implemented which is essential to the biopharmaceutical industry despite the fact that many basic researchers will be unfamiliar with it Viswanathan of Vineti provides an excellent introduction to QMS for advanced therapies.3 QMS is the most widely and effectively used framework for industrial quality management described by the ISO (International Organization for Standardization) worldwide QMS carves out the most essential mindset for sustainable quality once this mindset is recognised then the same spirit of quality management can be shared If this were to be translated into an academic expression we could argue that QMS requires one to ‘not stick to the beauty of craftsmanship but instead quantitate and think objectively.’ In other words it reminds us that cell culture has to be more data-based Our group began to understand cell culture from a quantification of ‘how people move’ (what we refer to as the ‘flow line’) during their cell culture By setting up two network cameras in the laboratory we recorded 38 operators running daily subcultures (93 experiments) and quantified how they spent their time under the same culture protocol.4 We discovered two things: This unique investigation implies that ‘mindset’ is more important than ‘career length’ and one’s mindset can be improved effectively when one is presented with objective data The mechanisation of cell culture is a highly expected solution in cell manufacturing the major problem is that no one can define the ‘parameter value’ needed to describe the impact of their hands (the impact of pipetting stress we quantitated the mechanical stress in cell culture We quantified the vibration frequency and acceleration amplitudes the two parameters that consist of mechanical vibration to understanding the parameter range of vibration stress during cell culture.5 This revealed that not only tapping to collect cells but also the shock of closing incubator doors or simply placing them onto a clean bench (which continuously vibrates due to the effect of motor fan) have unexpected vibration impact we succeeded in designing an experiment to evaluate the level of vibration stress that is critical and what level of stress can be detected by AI image analysis Quantification opened our eyes to the importance of the design space With difficult cells, craftsmanship is typically essential to establish cell culture it is often difficult to understand what has changed and what made the improvement in a craftsman’s cell culture We therefore attempted to quantify the effect of technical skill for subculturing iPS (induced pluripotent stem) cells by label-free AI image analysis When we quantified the total profile of iPS colony morphologies between sub culture skillsets our data revealed that the ‘expert technique’ is slightly better than ‘easy protocol’ but was more at risk of being affected by the technical level the cost and benefit of ‘expert training’ and ‘automation design’ could be objectively discussed Our study indicates that cutting-edge technology such as AI image analysis can offer a great opportunity to change our present mindset in cell culture Objective quantification efforts will lead us towards a deeper knowledge about the cell culture and should also lead us to realise the risks inherent in future cell manufacturing It should be the next generation mindset that leads us to QMS and thus to more consistent and more safer advanced therapy Please note, this article will also appear in the fifth edition of our quarterly publication Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Innovation News Network brings you the latest research and innovation news from the fields of science Disclaimer: This website is an independent portal and is not responsible for the content of external sites.Please Note: Phone calls may be recorded for training and monitoring purposes.© Pan European Networks Ltd Matthew Sua had a touchdown reception on offense and a sack on defense tonight for the Cimarron-Memorial football team in a 16-12 win over Democracy Prep Joseph Noel passed for a pair of touchdowns for the Spartans and Travis Earvin also had a sack to go along with a fumble recovery “We definitely played better tonight,” Spartans coach Shane Kanie said “We had pieces to win our previous games; tonight we put all of those pieces together.” Michael Sabina passed for two touchdowns and rushed for a third to help the Cimarron-Memorial football team win the Duel in the Desert game with Cheyenne “There’s nothing better than winning a rivalry game,” Cimarron coach Shane Kanie said Ayouba Sumoaro had both receiving touchdowns for the Spartans interceptions were had by Isiah Feathers and Gilrelle Patterson “Super proud of these kids and what they accomplished tonight,” Kanie said “Hopefully it can roll over to the rest of the season.” Seiya Kanie is abruptly asked out on a date by Isuzu Sento and whisked away to Amagi Brilliant Park; a theme park just outside of town poorly maintained and lacking any customers Isuzu has an ulterior motive in bringing Kanie here; the park is not just any park but home to many creatures from the magical realm of Maple Land that survive on the happiness of humans the park needs to bring in 500,000 more customers by the end of July otherwise it’ll be shut down and the residents will be not just out of a job but also a home Kanie has been prophesied to save the park from extinction but in a way it makes sense; theme parks (in fact most tourist attractions) are often a whole world in themselves It’s not unusual to have employees (or cast members) work very long unsociable hours and often have to step in and help with other departments in tight spots having the majority of the cast and by extension the park to be just a mini-world full of fairy creatures doesn’t seem like a huge leap in logic there’s not a lot of time or effort put in to really develop the history of the said magical realm You see a lot of the creative cast of characters from dragons cash registers and such) running around the park and you get to know the majority of them well in the 13-episode series but the actual ‘magic’ side of their personalities is barely explored there are four elemental fairies that all have individual abilities of controlling their appropriate element; we assume it’s part of their show but we never actually SEE any of it Another example is when Kanie is given the power in the first episode to read people’s minds and it’s a big push into him accepting the new role after Episode 2 it’s only used twice more and never spoken of in-between it’s a test of character that Kanie doesn’t feel the need to exploit his new-found gift in order to succeed in every challenge thrown at him yet if you’re going to introduce a power like that and not have it affect his character or contribute to an arc then the question remains: why bother at all There is a little development in Princess Peach’s Latifa’s backstory in the final push towards the finale but it feels more like an apologetic afterthought that was added in rather than something that should have been given more focus over the past episodes the theme park environment and its journey from a deserted place to popular attraction is not only the show’s USP but the strongest feature of the anime Kanie is guilty of being a male-power fantasy as he’s been given complete control of the whole park has a beautiful lady as his secretary and the power to read people’s minds from the Princess of Maple Land despite his narcissist nature and abrasive sense of humour he actually works his butt off to get the numbers the park requires to stay afloat He doesn’t rely on others to do his job for him or expect everything to just work out somehow because of some ‘prophecy’ instead from day one he works long hours to fix what’s broken in the park try new strategies to get customers in and spends time with every aspect of the theme park and its cast to really push them to do their best his attitude and work ethic rubs a lot of people the wrong way but you can’t deny the results and the fact that he is trying hard Through him we get to know the very large cast and how they contribute to the park’s survival so as the episodes progress we really get invested in the final climax as they try SO hard to bring in the customers It’s a complete and emotionally fulfilling arc you can really get invested in and you want them to succeed because they all worked together to get there Despite the majority of the female casts being in very skimpy outfits and having very large boobs the series is actually very conservative when it comes to fan service we do have the occasional bath-tub scene with Izusu but the anime never feels the need to point the camera directly at the girls’ bums or force the breasts to jiggle constantly; there’s fair amount of eye-candy for the right audience but it never becomes a distraction for everyone else Instead it’s the personalities behind said bodies that work in the fan service’s favour the humour relies a lot on silly antics of the mascot characters and general park fun which works for the majority of the time however there are random moments when the comedy takes a turn for the bizarre; for example when they’re interviewing for additional team members one interviewee comes in randomly with a stab wound and is bleeding over the managers whilst the girl is still smiling Then there’s a couple of mascots performing seppuku for a one-off joke in a promo video for the park They really take you out of the show as they come out of nowhere and not in a ‘funny ‘cos it’s random’ sort of way  In addition; the three main leads are named after famous R’n’B artists – 50 Cent Queen Latifah and Kanye West – said characters have nothing to do with them (aside from Kanie’s ego probably equal to Kanye’s) so it’s random trivia that adds next to nothing Animation is surprisingly top quality for a short show based upon an unusual premise but considering the director of Full Metal Panic? Fumoffu is at the helm with the same production company that animated both series it’s not surprising that they pulled out all the stops for this and the whole theme park feels vibrant with colour and life; it’s a show that definitely deserves the extra cash spent on its Blu-ray release An interesting observation is how the designs of the fairy/mascot characters are ‘flatter’ than the humans shadows and details in every outfit – it helps separate the abnormal magical creatures from the standard-looking characters English dub voice for Kanie is Adam Gibbs who provides a mixed bag performance; he delivers on the character’s narcissistic side brilliantly but when the character has more animated moments he falls flat on too many occasions in one episode when several cast members pose as him and Adam needs to deliver how each person would portray his voice so whether he was poorly directed for the more comical bits or just simply couldn’t achieve it was hard to say As for Molly Searcy as Izusu she succeeds with the perfect balance between hilarious monotone and hard-to-crack military girl when the situation calls for it; easily the best performance of the English dub Discs extras include the OVA and clean opening and closing however for the collector’s edition you will also get a special Blu-ray case Amagi Brilliant Park may not go down in history as a classic or be highly remembered a year from now but it’s a solid series for any anime fan to give a least one watch Its unique premise with a strong cast and mostly solid humour gives it a worthy place to add to your collection editor and director with a love for video games Arata Kusaga’s life changes when the sun turns black and his world (ours?)  – and his beloved cousin Hijiri – are swallowed up by the Breakdown Phenomen. Gifted with a grimoire by Hijiri, Arata sets out to find a way to undo the damage and save her. The answers lie in the Royal Biblia Academy, … Continued This time last year I sat down to review the first season of KonoSuba (a review you can read here) and at the end of the article I mentioned how excited I was for the second season. Fast forward a year and I’ve just finished watching Season 2. Has it held up to my original … Continued Episodes 165 to 175 Warning: Review contains episode spoilers “It does not do to leave a live dragon out of your calculations, if you live near one.” – J. R. R. Tolkien. This collection marks the end of the original first series of Fairy Tail. Fortunately the next parts are coming out soon, which is … Continued “Nor is it seemly, after wiping your nose, to spread out your handkerchief and peer into it as if pearls and rubies might have fallen out of your head.” – Erasmus After recapping the events from the last series in a clip show for the first episode, we witness Jaden and his friends starting their … Continued It’s a fairly quick turnaround in the UK for the release of the second series of Fairy Tail although as the title of the collection makes clear it is just a continuation of what was going on before Having been established since February 2004 Anime UK News is constantly striving to deliver high quality UK anime news and reviews to your computer screens each and every day being sure to maintain high standards of writing and reliability Designed and maintained by devoted anime fans Anime UK News and it’s fledgling forum community is growing with each passing month proving we are an ambitious and trusted resource for UK-based anime fans and beyond Sentai Filmworks announced with a video on Thursday that Adam Gibbs will play Seiya Kanie in its English dub of Amagi Brilliant Park Gibbs joins Cindy Lou Parker as Princess Latifah Sentai Filmworks will release the series on Blu-ray Disc and limited edition Blu-ray/DVD combo pack on February 28 The "slapstick drama" begins with Seiya Kanie a high school boy who is invited on a date in an amusement park by a mysterious beautiful transfer student named Isuzu Sento and is asked to be the acting manager of this "disappointing amusement park in the Tokyo suburbs." Your browser does not support JavaScript, or it is disabled．Please check the site policy for more information National Report Aichi Prefecture--A 14-year-old student who allegedly stabbed to death another student on Nov 24 at a municipal junior high school here is believed to have smuggled the knife into the school in a backpack to the Nagoya District Public Prosecutors Office on the morning of Nov after upgrading the charge against him from attempted murder to murder was also a third-year student at the school the alleged assailant came to the school on the morning of Nov 24 with a knife with a 20-centimeter blade hidden in his backpack which he always carried when going to school who was in a classroom on the second floor to come to a corridor and stabbed him in the stomach According to the prefectural police and the junior high school returned to the classroom under his own power A teacher called a staff room and reported the need to call an ambulance Police were notified through a 110 call at around 8:10 a.m 24 that there was trouble between students and that someone had been stabbed The victim was rushed to a hospital but pronounced dead The alleged attacker is reported to have put down the knife after being instructed to do so by teachers Teachers then restrained him and police officers from the Kanie police station who rushed to the school made an emergency arrest on suspicion of attempted murder Prefectural police consider that it is likely that the attack was premeditated as the student has confessed to having bought the knife on his own before the incident It is believed that the victim was stabbed from the front and that the knife penetrated his liver The prefectural police are expected to conduct a judicial autopsy on the victim to analyze the injuries on Nov The alleged attacker reportedly told police that he had been bullied Police have been investigating the motive for the attack including whether his account about bullying is true They will also talk to other students at the junior high school as part of the investigation The Yatomi Board of Education says that it is not aware of any bullying reports involving the boy The two students are in different third-year classes at the junior high school but were in the same second-year class in the last academic year They also attended the same elementary school The principal of the junior high school told a news conference that the school was unaware of any issues between the two students 63-year-old caregiver saves woman’s life from knife attack Hong Kong police arrest 4 from university student union Sources: Train stabbing suspect began planning rampage in June Schools across nation fighting rampant surge of online bullying Hiroshima man arrested over fatal stabbing of woman in 2001 Information on the latest cherry blossom conditions Please right click to use your browser’s translation function.) A series based on diplomatic documents declassified by Japan’s Foreign Ministry Here is a collection of first-hand accounts by “hibakusha” atomic bomb survivors chefs and others involved in the field of food introduce their special recipes intertwined with their paths in life A series about Japanese-Americans and their memories of World War II In-house News and Messages No reproduction or republication without written permission The official website for the television anime of Kawada's Hinomaru Sumo (Hinomaru Zumō) manga revealed on Sunday that Demon Kakka (formerly Demon Kogure) will join the anime's cast as the character Dr The anime premiered in Japan on October 5. Funimation and Crunchyroll are streaming the series as it airs. The series will have 24 episodes Kawada launched the manga in Weekly Shonen Jump in May 2014. Shueisha published the 22nd volume on October 4, and will publish the 23rd volume on Tuesday. The story centers on the "small" new student Ushio Hinomaru! who joins the weak sumo club of Oodachi High School Sources: Hinomaru Sumo anime's website, Comic Natalie Strangely stiff white herons have emerged around treetops near the Higashi-Meihan Expressway in Yatomi A specialist used to working at heights who has experience pruning trees was seen placing these decoy herons in a man-made grove of trees Speakers were also set up on the ground to play the bird's call This interchange and the Kanie Interchange about 5 kilometers away in the town of Kanie used to be nesting sites for colonies of several thousand herons But the last time the birds were seen nesting at Yatomi was in 2016 Expressway operator Central Nippon Expressway Co and the Aichi prefectural branch of the Wild Bird Society of Japan have been working to move some of the herons to Yatomi Many herons used to nest in colonies in the countryside of satoyama areas where woodlands meet cultivated fields the rapid building of housing and other development projects have deprived the birds of their nesting sites The birds then began nesting in trees around interchanges where they meet few natural predators and are not bothered by humans the herons were seen as a nuisance because of their droppings and collisions with vehicles on the expressway Central Nippon Expressway then heightened fences and posted warning signs to reduce accidents in cooperation with the Wild Bird Society and other organizations has been working to realize the idea of a symbiotic relationship between herons and the expressway there were some months when more than 5,000 herons gathered at Kanie Since the idea of a symbiotic relationship cannot work if such congestion continues the company has tried various ways to make some birds move to Yatomi Using only decoys and artificial nests have failed to attract the herons so this year a speaker has been set up to project the bird's call to let the herons know it is a safe place to live "We hope this year's experiment succeeds," said Tetsuya Nozawa deputy director of the prefectural branch of the Wild Bird Society of Japan "and we can discover clues to solving problems between wild birds and humans that are taking place around the nation." Read more from The Japan News at https://japannews.yomiuri.co.jp/ A television anime adaptation of Makana's 25-Sai no Joshi Kōsei: Kodomo ni wa Oshierarenai Koto Shite Yaru yo (25-Year-Old High School Girl: I'll Do What Can't Be Taught to Children) manga has been green-lit for a January 7 premiere on Tokyo MX and other channels The romance story centers around Hana Natori good-natured 25-year-old woman whose cousin refuses to go to high school Hana takes her cousin's place and attends the high school Hana's ruse is discovered by her former high school classmate Okito Kanie — who happens to be the high school's world history teacher The anime will have a "regular edition" on television, and a "complete edition" with explicit scenes that will be available on ComicFesta's Anime Zone service Chiharu Sawashiro (regular edition), Kyohei Morishita (complete edition) as Okito Kanie Tomohito Takatsuka (regular edition), Tetsuto Furukawa (complete edition) as Naoyuki Aida Saki Hazuki is performing the theme song "Reunion." Source: Comic Natalie UN Secretary-General António Guterres on Monday announced appointment Malawi female scientist Professor Nyovani Madise and 14 other eminent scientists to draft the 2023 Global Sustainable Development Report Professor Madise—who is the Director of Research and Development Policy and Head of the Malawi office of the African Institute for Development Policy—is a sister to Dr Sunduzwayo Madise According to UN press statement released on Monday this independent group of scientists and their Report will inform the follow-up and review of the 2030 Agenda for sustainable development and the Sustainable Development Goals “The Report aims to strengthen the science-policy interface and to serve as a strong evidence-based instrument to support policymakers in promoting poverty eradication and sustainable development,” reads the statement The next Global Sustainable Development Report will be published in 2023 feeding into the high-level global review of the 2030 Agenda at the United Nations in September of that year The statement adds that following an extensive consultation process the UN Secretary-General has appointed a diverse group The 15 scientists are: John Agard (Trinidad and Tobago) The Report will provide guidance on the state of global sustainable development from a scientific perspective address new and emerging issues and challenges and offer recommendations for action by governments and other actors Banja la a Madise lidadalitsika ndi school eti Kuli Suduzwayo ndi twin brother wake Dingiswayo Madise okha okha anyamata ovaya Congrats madam for international recognition Fly that flag really high girl……. This is very remarkable and we’re so so so proud of you May God guide in this challenging yet very rewarding assignment I was privileged to have been in the same first year mathematics class with Prof Madise at Chanco in 1978 Malawi seems to have distinguished academics honestly i have googled her CV and her CV is impressive to the core The Malawi Network for Older Persons’ Organizations (MANEPO) has challenged Malawi Police Service (MPS) to immediately arrest and prosecute every...