2025 and is expected to run for two consecutive cours The visual and trailer were released ahead of the anime’s third episode premiere on April 21 Seiren) is directing the anime adaptation at animation studio Feel with Mai Otsuka (The Demon Girl Next Door) as character designer The Many Sides of Voice Actor Radio) as series screenwriter Sari Tagawa (Remake Our Life!) as color designer Fumito Nanba (Remake Our Life!) as compositing director and Makoto Takigasaki (The Yakuza’s Guide to Babysitting The original Summer Pockets visual novel was first released by Key in June 2018 for PC A Switch and Steam release followed in 2019 and 2020 The game features character designs from Na-Ga An updated version titled Summer Pockets Reflection Blue A standard edition with Windows 11 support and bonus physical items was released in September 2024 Crunchyroll is streaming Summer Pockets worldwide Hairi Takahara never expected summer to feel like a dream Sent to Torishirojima to sort through his late grandmother’s belongings lost memories begin to surface and he finds what he never knew he’d lost Source: Summer Pockets Official Anime Twitter Sign up for our daily Newsletter and stay up to date with all the latest news You are receiving this pop-up because this is the first time you are visiting our site You are using software which is blocking our advertisements (adblocker) we are relying on revenues from our banners So please disable your adblocker and reload the page to continue using this site.Thanks Japanese sweet potato exports have seen an increase driven by advancements in spoilage prevention technology and efforts to customize offerings for global markets Japan exported 6,200 tons of sweet potatoes marking a nearly tenfold increase in shipment value to 2.9 billion yen over the past decade The growth in exports accelerated after 2018 following the popularity of Japan-made potatoes in Singapore thanks to a Don Quijote store opening there in 2017 A spokesperson from Don Quijote highlighted the acceptance of their sweet potatoes noted for their high sugar content and quality accounts for 20 percent of Japan's sweet potato exports operating a significant storage facility and collaborating with 280 partner farms The farm exports around 1,000 tons of sweet potatoes to 11 countries Long transit times necessitate measures against spoilage with the farm employing techniques to heal harvest-induced potato scratches naturally In response to a foot rot outbreak in 2018 an agricultural business in Kagoshima Prefecture adopted the use of peracetic acid for disinfecting sweet potatoes a method that proved effective for export-quality potatoes as well This innovation emerged from the need to combat the disease that significantly affected sweet potato production in the region Kushima Aoi Farm also focuses on catering to international tastes and organizing tasting events abroad to identify consumer preferences in different markets Despite the challenges of high logistics costs and the risk of spoilage the farm remains optimistic about the international appeal of Japan-made sweet potatoes emphasizes the potential for global success with improved quality and distribution networks aiming to support their contract farmers through increased sales Source: The Asahi Shimbun Frontpage photo: © Dleonis | Dreamstime FreshPublishers © 2005-2025 FreshPlaza.com Your browser does not support JavaScript, or it is disabled．Please check the site policy for more information Japanese exports of sweet potatoes have been brisk thanks largely to technology to prevent spoilage and efforts to tailor the spuds to an increasing number of targeted areas around the world High-quality sweet potatoes from Japan are now being sent around Asia and to Europe Japan exported 6,200 tons of sweet potato in 2023 The shipment value rose nearly tenfold to 2.9 billion yen ($19.1 million) over the last decade after the operator of the discount store chain Don Quijote opened an outlet in Singapore in 2017 and Japan-made potatoes became a major hit in the city nation “Carefully selected Japanese potatoes with high levels of sugar content and quality were accepted as hot sweets,” said a public relations official from the Don Quijote operator sweet potatoes are served raw and baked at the company’s 47 outlets abroad located in Kushima at the southern tip of Miyazaki Prefecture holds the largest share in Japan’s sweet potato exports The agricultural corporation operates a 1,450-ton storage facility with about 100 staff members Kushima Aoi Farm annually handles 10,000 tons of sweet potatoes harvested from its own fields and 280 partner farms throughout Japan Around 1,000 tons of the potatoes are exported via container ship to 11 countries and regions mainly for sales at local supermarkets It takes one to two weeks for the products to reach nearby nations and more than a month for destinations in Europe Countermeasures to prevent potatoes from rotting during shipping are essential The temperature and humidity inside Kushima Aoi Farm’s storage house lined by shipping containers are kept high so that scratches on the potatoes from the harvest process can heal naturally Cork layers form over the scars like human scabs stopping pathogen invasion and reducing the risk of spoilage in delivery sprays peracetic acid to disinfect sweet potatoes at its storage house and lower the possibility of spoilage in the prolonged transportation The method was developed in response to the spread of foot rot a kind of mold that blackens the leaves and stems of sweet potato plants devastated sweet potato output primarily in Kagoshima and Miyazaki prefectures the disease has been brought under control to some extent through various approaches recalled opening the door of his company’s warehouse at the time and discovering 500 tons of sweet potatoes rotting and steaming Yahata came up with the idea of using peracetic acid He said the strategy has proved helpful for potatoes that are exported “The new method was born in responding to foot rot,” Yahata said “We successfully turned the trouble around.” which organizes tasting events at local venues overseas strives to cater to taste buds in each site The company said 99 percent of people “respond positively” when sampling Japanese-style baked sweet potatoes prepared with dedicated equipment consumers’ preferences vary by country and region The sticky Beniharuka variety is occasionally described as “too clingy” in Germany wins over consumers in Hong Kong but sees less success in Southeast Asia Kushima Aoi Farm secures a range of potato species to accommodate diverse tastes worldwide To ensure stable production of sweet potatoes throughout the year for exports Kushima Aoi Farm signs contracts with farmers around the country Although the environment for potato exports may look favorable Accidentally delivering spoiled potatoes can result in huge losses the profitability for exports is no higher than that in the domestic market who is responsible for the overseas expansion plan “Japan-made potato species will surely sell well internationally if we further improve their quality by refining maturing techniques,” he said “We will be building distribution networks in and outside Japan to increase sales for the sake of our many contract farmers.” Famed shochu maker hopes to wow market with barley Sweet potato the power behind shochu distiller’s goal to cut CO2 Dried sweet potato-themed train rides local rails in Ibaraki Information on the latest cherry blossom conditions Please right click to use your browser’s translation function.) A series based on diplomatic documents declassified by Japan’s Foreign Ministry Here is a collection of first-hand accounts by “hibakusha” atomic bomb survivors chefs and others involved in the field of food introduce their special recipes intertwined with their paths in life A series about Japanese-Americans and their memories of World War II In-house News and Messages No reproduction or republication without written permission The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission All content on this site: Copyright © 2025 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply. Volume 8 - 2021 | https://doi.org/10.3389/fnut.2021.548076 This article is part of the Research TopicAgeing-Related Symptoms, Kampo Medicine and TreatmentView all 16 articles was administered to two patients with idiopathic pulmonary fibrosis (IPF) over a period of 12 weeks to improve loss of appetite and lassitude as well as increases or increasing tendencies in body weight Case 2 showed no changes in appetite but improvements in lassitude and no deterioration of breathlessness His body weight and his blood albumin and Hb levels increased or showed increasing trends a trend for improvement of respiratory function was observed ninjin'yoeito trended to improve the subjective symptoms and nutritional status of a patient with pulmonary fibrosis Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive disease in which advanced fibrogenesis results in irreversible honeycomb lungs. Antifibrotic agents can be used to treat IPF but the efficacy is limited. The mean lifespan after diagnosis of IPF is 3–5 years; and the mean lifespan after exacerbation of IPF is 2 months or less. IPF is associated with a very high mortality rate (1) Accompanying the progression of restrictive ventilatory defect the IPF patient may complain of subjective symptoms Since these symptoms significantly reduce patients' quality of life we decided to administer ninjin'yoeito as an available medicine for malaise under universal health coverage in Japan This report describes the administration of ninjin'yoeito to 2 IPF patients who had experienced loss of appetite and malaise and a clear therapeutic response was observed There was no occurrence of transaminitis during the treatment He had an increase in walking distance from 383 to 440 m in a 6-min walk test (6MWT) 12 weeks after administration The value of the lowest SpO2 at 6MWT remained unchanged at ~90% for 12 weeks The CT finding did not show significant changes before and after treatment with ninjin'yoeito The results of pulmonary function tests and biomarkers before and after ninjin'yoeito treatment in Case 1 Chest radiograph and CT scans of Case 1 showing elevation of bilateral hilar opacities and subpleural reticular opacities in the bilateral lung fields Case 2, a 59-year-old male was referred to our hospital for respiratory failure and was clinically diagnosed as IPF based on the guidelines [Raghu et al. (2)] (Figure 2) Chest radiograph and CT scans of Case 2 showing reticular opacities and some ground-glass attenuation in the bilateral lung fields A 6MWT after 14 weeks of administration showed improvement in the lowest SpO2 (from 87 to 91%) while the walking distance decreased from 360 to 300 m The results of pulmonary function tests and biomarkers before and after ninjin'yoeito treatment in Case 2 Investigation of additional cases will help to clarify the effect of ninjin'yoeito for the treatment of respiratory diseases We believe that our study makes a significant contribution to the literature because the findings showed that NYT can improve fatigue and contribute to maintaining quality of life in IP patients The original contributions presented in the study are included in the article/supplementary material further inquiries can be directed to the corresponding author/s The studies involving human participants were reviewed and approved by Fukuoka University Hospital Ethics Committee The patients/participants provided their written informed consent to participate in this study Written informed consent was obtained from the individual(s) for the publication of any potentially identifiable images or data included in this article HK conducted the study and wrote the manuscript All authors contributed to the article and approved the submitted version The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest Guidelines for the Treatment of IPF 2017 (in Japanese) Google Scholar Diagnosis of idiopathic pulmonary fibrosis An official ATS/ERS/JRS/ALAT clinical practice guideline Reliability and validity of the Japanese version of the simplified nutritional appetite questionnaire in community-dwelling older adults Screening older people at risk of malnutrition or malnourished using the simplified nutritional appetite questionnaire (SNAQ): a comparison with the mini-nutritional assessment (MNA) tool Reliability and validity of the Japanese version of the Chalder Fatigue Scale among youth in Japan CrossRef Full Text | Google Scholar Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease Ninjin'yoeito improves cachexia in the respiratory system (in Japanese) Google Scholar Ninjin'yoeito activates ghrelin-responsive and unresponsive NPY neurons in the arcuate nucleus and counteracts cisplatin-induced anorexia Ninjin'yoeito ameliorates anorexia and decrease in the nest building via a dopamine D2 receptor-dependent manner in a novel murine apathy model (in Japanese) Inhibitory effects of β-chamigrenal isolated from the fruits of schisandrachinensis on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages Therapeutic effect of a traditional Chinese medicine ren-shen-yang-rong-tang (Japanese name: Ninjin'yoeito) on nitric oxide-mediated lung injury in a mouse infected with murine cytomegalovirus Pirfenidone attenuates bleomycin-induced changes in pulmonary functions in hamsters Pirfenidone inhibits dimethylnitrosamine-induced hepatic fibrosis in rats Effects of Hochu-ekki-to and Ninjin'youeito on porcine serum-induced liver fibrosis in rats Ishii H and Fujita M (2021) Case Report: Efficacy of Ninjin'yoeito Treatment for Idiopathic Pulmonary Fibrosis Received: 01 April 2020; Accepted: 29 March 2021; Published: 29 April 2021 Copyright © 2021 Kushima, Ishii and Fujita. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Hisako Kushima, aGt1c2hpQGZ1a3Vva2EtdS5hYy5qcA== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Metrics details ultra-dilute contaminants of concern has been a primary challenge for clean water technologies Chromium and arsenic are among the most prevalent heavy metal pollutants in urban and agricultural waters with current separation processes having severe limitations due to lack of molecular selectivity we report redox-active metallopolymer electrodes for the selective electrochemical removal of chromium and arsenic An uptake greater than 100 mg Cr/g adsorbent can be achieved electrochemically with the bound chromium ions released in the less harmful trivalent form we study the metallopolymer response during electrochemical modulation by in situ transmission electron microscopy The underlying mechanisms for molecular selectivity are investigated through electronic structure calculations indicating a strong charge transfer to the heavy metal oxyanions chromium and arsenic are remediated efficiently at concentrations as low as 100 ppb in the presence of over 200-fold excess competing salts The main features of these systems are the fast electron transfer and redox processes at moderate potentials (<1.2 V vs which allow reversible adsorption and desorption of ionic components by electrochemical modulation of charge and hydrogen-bonding interactions between carboxylates and the metallopolymers targeting the molecular level recognition of heavy metal oxyanions (HMOAs) would overcome a major challenge for environmental remediation especially in the presence of competing excess anions the nature of the interaction of these metallopolymers with relevant transition metals has not yet been fully explored PVF-functionalized electrodes are applied in the removal of anionic chromium and arsenic oxyanions under a range of different concentrations and electrolyte conditions we provide insight into the transformation of chromium which is reduced to its trivalent form during release on reduction of the metallopolymer adsorbent we demonstrate the high selectivity of Faradaic electrodes for HMOA contaminants with the adsorption and desorption controlled purely by electrochemical modulation The fundamental interactions regulating the selectivity are shown to depend strongly on solvation effects and on the charge transfer characteristics of the ion pair regulated by the electronic structure of the anions and overcoming simple electrostatic attractions we pursue the nanoscale observation of our metallopolymer film under ion adsorption using in situ electrochemical transmission electron microscopy (TEM) In situ TEM allows the direct high-resolution imaging and observation of an electrochemical response of a material interface and can thus shed light on the kinetics and morphological changes during ion insertion in a direct manner Our results are expected to serve as an important platform for tailoring advanced redox materials targeting heavy metal recovery and remediation Electrosorption of chromium oxyanions by PVF-CNT a Scanning electron microscopy (SEM) images of the PVF-CNT electrodes before the adsorption of chromium and EDS mapping of the iron of the metallopolymer b SEM micrographs and EDS mapping after chromium adsorption The area corresponding to the PVF is also saturated with the adsorbed Cr c Comparison of chromium-uptake capacity of PVF-CNT and CNT electrodes for 1 mM (NH)4Cr2O7 in 20 mM NaClO4 and in 20 mM NaCl No Cr adsorption occurs on a PVF-CNT electrode without potential and a much higher adsorption capacity for PVF-CNT than pristine CNT is observed at +0.8 V vs d Equilibrium isotherm for PVF-CNT at +0.8 V vs Ag/AgCl adsorption for a range of (NH)4Cr2O7 concentrations in 20 mM NaClO4 e Adsorption kinetics for Cr at 1 mM (NH)4Cr2O7 in 20 mM NaClO4 f Effect of discharge potential on regeneration efficiency of the PVF-CNT electrodes measured by the normalized mass of Cr released (mg Cr/g PVF polymer) and dynamic results were compared to a diffusion-controlled case in which the electrode was left in the desorption solution under no applied potential Scale bar for high-resolution SEM is 800 nm and scale bar for EDS and Fe/Cr mapping is 50 μm Error bars represent standard deviations from three replicate measurements Investigation of the reversibility of the electrochemically mediated capture-and-release process a Recyclability of the electrode over a number of discharge cycles (+0.8 V adsorption as given by the normalized mass released (in blue) and the regeneration efficiency (%) (in red) the latter denoting the relative amount of Cr recovered relative to that adsorbed in each cycle b The E-pH diagram for chromium speciation predominance constructed with commercial thermochemical software (FactSage) at 25 °C for 1 mM total chromium concentration in the liquid phase The adsorption and desorption potentials are noted with the range of solution conditions marked both for adsorption (in blue) and desorption (in orange) c The Faradaic reactions occurring at the surface of the electrode pair are shown during both adsorption and release hexavalent chromate is captured by the anode through selective binding reduction of ferrocenium to ferrocene and of Cr(VI) to Cr(III) occurs pointing to a slower reduction of the Fc units and subsequent release of chromium The higher release at an applied potential of 0 V implies an optimal tradeoff between reduction of the metallopolymer and re-adsorption of any cationic chromium Our method couples an electrochemical reduction step following removal of the chromate ions from the feed solution during the oxidation step A liquid-phase spectrophotometric assay to evaluate the degree of Cr(VI) conversion to Cr(III) in the aqueous phase before and after reduction showed that both the stock solution (containing 1 mM NH4Cr2O7) and the supernatant after adsorption contained Cr(VI) as the majority species (>98%) The preservation of the hexavalent form of chromium even after electrochemical treatment under oxidation indicated that application of +0.8 V vs Ag/AgCl does not change the oxidation state of bound Cr(VI) the neutral Fc polymer showed no molecular affinity for the anions as both XPS and spectrophometric assays indicated no conversion of Cr(VI) to Cr(III) 81% of the released chromium was found to be in the trivalent state of Cr(III) providing strong evidence that the electrochemically mediated release step promotes the transformation it is shown here that for cathodic regeneration of PVF water oxidation aids in the regulation of the solvent pH in favor of the equilibrium speciation of chromium and enhances the environmental remediation process Mechanistic study of binding selectivity and generalization to arsenic contaminants solvation corrected binding energies calculated by DFT between ferrocenium and a range of oxyanions The binding energy for chromium and arsenic-based anions is remarkably stronger than for the purely electrostatic attraction of chloride and perchlorate b Electronic structure optimization of chromate (CrO42−) with ferrocenium (Fc+) indicating that despite similar structural effects to perchlorate binding the main governing contribution to selectivity is derived from charge transfer c Adsorption capacity of arsenate at 1 mM KH2AsO4 in the presence of 20 mM NaCl using PVF-CNT under different applied potentials d Removal efficiency of chromium and arsenic under different water matrices including a municipal secondary effluent solution spiked with Cr and As at 100 ppb for 120 min of charging (4 mg PVF on the electrode) The strong binding of Fc+ with CrO42– and HAsO42– corresponded to more electron loss from the anions (0.30 indicating that charge transfer plays a dominant role in regulating binding selectivity An atom-by-atom analysis of the electron transfer showed that the oxygens on the HMOAs are much more susceptible to losing electrons to ferrocenium than those from the non-HMOAs due to significant differences in their intrinsic electronegativities as the ClO4– (containing only halide and oxygen) is clearly more electronegative than CrO42– (containing a heavy metal center); thus the electron cloud of ClO4– is much less polarizable than that of CrO42– This electron cloud polarizability/charge transfer can be quantified in terms of the ionization potential of the solvated anions which can be interpreted as the energy required to remove one electron A higher IP value indicates a higher barrier for electron transfer roughly correlating with a weak Fc+ binding the calculated IP values of Cl– and ClO4– (>7.2 eV) are higher than those of the chromates and arsenates studied here the IP values for CrO42– and HAsO42– are smaller than those for all other anions (5.6 and 5.2 eV) consistent with the higher charge transfer and stronger binding zero-temperature calculations cannot be compared directly with experimental binding energies We performed entropy-corrected binding calculations to investigate the effect of finite temperatures on the intermolecular interactions and thereby provide more meaningful values for the binding energies Owing to the heavy computational costs for the optimization of the structures for this task (see details in Methods) and HAsO42– as validation cases to explore the importance of vibrational entropy in determining molecular selectivity The binding energies of these four compounds with ferrocenium accounting for both solvation and entropy corrections On comparison of these data with zero-temperature binding energies (0.02 it is evident that vibrational entropy contributes greatly to the selectivity of the binding events the overall trend in the interaction energies predicted by the zero-temperature calculations is preserved These results further strengthen our mechanistic understanding of the electronic nature of the interactions and of the strong charge transfer-mediated discrimination between these compounds These guidelines are expected to provide important future design rules for HMOA capture and establish redox electrodes as electrochemically efficient and molecularly tunable platforms for chemical and environmental separations limited only by the capacity of the electrode no second-phase particle growth was observed in the TEM measurements under the voltage ranges tested indicating that molecular binding plays a major role and that phase transformation processes are not significant under these conditions we have successfully investigated the anion-selective properties of the redox metallopolymer Fc for the removal of chromium and arsenic HMOAs from water under realistic operating conditions PVF-CNT electrodes were used for the selective adsorption of two of the most prevalent and toxic HMOAs with a high adsorption capacity (>100 mg/g at saturation) and remarkable regeneration properties a coupling of the release and regeneration of the electrodes results in transformation of the hexavalent pollutant into the less harmful trivalent form this two-step electroswing process allows for the purification of a water stream under dilute pollutant concentrations while simultaneously reducing the byproduct toxicity and is an order of magnitude more active compared to various ion-exchange beds or even non-redox electrochemical systems making it suitable for household and remote-site water purification In situ TEM measurements with an electrochemical liquid cell provided direct evidence of the redox-driven anion insertion into the poly(vinyl)ferrocenium film under charge and the high affinity of the films for dichromate anions Our work highlights the power of redox-mediated/Faradaic systems for the selective environmental capture and remediation of HMOAs by showing strong binding selectivity and the possible coupling to an electron transfer process that mitigates the toxicity of the adsorbed element the counter electrode reactions were found to be highly synergistic with the environmental transformation occurring at the metallopolymer electrode pointing to the important role that electrochemical engineering can play in enabling an efficient reactive separation process We also envision the use of these platforms for the recovery and valorization of waste streams in various chemical and electronic industries for a wider range of transition metal compounds A stock solution A of 80 mg PVF (Polysciences Inc.) and 40 mg multiwalled CNT (Sigma) was dissolved in 10 mL anhydrous chloroform and a stock solution B of 40 mg of CNT in 10 mL chloroform was also prepared The two stock solutions were sonicated for 2 h in icy water and stocks A and B were mixed in a 1:1 ratio Electrodes were drop cast using 50 μL of solution the immersed electrochemical area was equivalent to 1 cm2 (1 cm by 1 cm) with 2 mg of PVF per electrode The electrochemical separations were carried out on a BASi cell in a three-electrode configuration with an aqueous Ag/AgCl reference electrode 5 mL of solution was used for the isotherm and equilibrium data measurements A background electrolyte concentration of 20 mM of either NaClO4 or NaCl was used 0.1 mL aliquots were taken at variable time points for ICP assay All electrochemical studies were performed on a VersaSTAT 4 potentiostat (Princeton Applied Research) with automatic IR compensation between 5 Ω and 50 MΩ The uptake values are reported as the adsorption capacity normalized by the mass of the polymer (2 mg of PVF per electrode chronoamperometry was used for all the separation tests in this work with chronopotentiometric measurements yielding comparable results Inductively-coupled plasma optical emission spectroscopy: a PerkinElmer Optima 8000 ICP-OES spectrometer was used to quantify the concentrations of chromium and arsenic in solution To establish a baseline for the ICP readings a 2% w/w HNO3 solution was prepared from 70% HNO3 (Sigma-Aldrich and used as the solution into which the adsorbed species were electrochemically discharged as well as to dilute any concentrated samples Calibration solutions were made by diluting the ICP calibration standards (1000 ± 2 mg/L A total of four calibration samples were prepared for each of the three cations examined and 0.1 mg/L (with 2% w/w HNO3 being 0 mg/L) and the instrument was also set to perform a quality control check by resampling the 10 mg/L calibration solution to ascertain its calibrated concentration measurement Each solution sample was measured in triplicate by the spectrometer to yield an averaged reading To measure the content of Cr(VI) in the aqueous samples a one-step colorimetric assay was used (BioAssay Systems QuantiChrom Chromium Assay Kit The method relies on a mix-incubate-measure protocol and the samples of the solution were pre-diluted to fit within the 0.02–2 mg/L range for the assay Whereas the amount of Cr(VI) was directly measured the amount of Cr(III) was estimated by the difference in the total amount of Cr from ICP relative to that of Cr(VI) and also confirmed by an acid treatment to convert all the Cr(VI) to Cr(III) we used multiple different geometric configurations as initial structures for each system and then optimized them without any symmetry constraints The binding energy is defined as BE = EA–/2– + EFc+ – EAFc0/– where E refers to the total energy of the studied moiety the overall interaction trend in the gas phase and with solvation was the same we base our discussions solely on the more physically relevant interactions with water solvation In order to account for the entropy contribution to the binding between the ferrocenium and anionic moieties we calculated their Helmholtz free energy at room temperature (300 K) with the solvation effect included Following careful optimization of the structures with the convergence criteria of 1 × 10–7 eV and 1 × 10–5 eV/Å for the total energy and force components the vibrational frequencies were calculated through perturbation of each atom in all three directions The Helmholtz free energy can be written as: The second and third terms correspond to the zero-point energy and vibrational energy at finite temperatures The ωs refers to the sth vibrational frequency The room temperature binding energy BE (T) was then evaluated by a simple difference: BE(T) = FFc+(T) + Fanion(T) – FFc anion(T) Variations in the temperature-dependent electron occupation and electron–phonon coupling were neglected All these calculations were performed in VASP code All relevant data are contained within the article Supplementary Information and available from the authors upon reasonable request The movies are uploaded as Supplementary Information to the paper and have been compressed for reduced file size and ease visualization Original files can be requested from the authors at x2su@mit.edu and kushima@mit.edu The future of seawater desalination: energy Groundwater contaminated with hexavalent chromium [Cr (VI)]: a health survey and clinical examination of community inhabitants (Kanpur Adsorption mechanism of hexavalent chromium by redox within condensed-tannin gel Removal of chromium from aqueous solutions by treatment with carbon aerogel electrodes using response surface methodology Alternatives for Ground Water Cleanup (National Acadmies of Sciences Reduction of hexavalent chromium by amorphous iron sulfide Changes in aquatic toxicity of potassium dichromate as a function of water quality parameters Comparison of arsenic(V) and arsenic(III) sorption onto iron oxide minerals: implications for arsenic mobility Adsorption of chromium(VI) from aqueous solutions using cross-linked magnetic chitosan beads Chromium VI adsorption on cerium oxide nanoparticles and morphology changes during the process Magnetic SiO2 @CoFe2O4 nanoparticles decorated on graphene oxide as efficient adsorbents for the removal of anionic pollutants from water Removal of chromium from water and wastewater by ion exchange resins Rapid removal of organic micropollutants from water by a porous beta-cyclodextrin polymer Use of soft electrodes in capacitive deionization of solutions Low energy desalination using battery electrode deionization Hybrid capacitive deionization to enhance the desalination performance of capacitive techniques Energy consumption and constant current operation in membrane capacitive deionization Electrosorption at functional interfaces: from molecular-level interactions to electrochemical cell design Review on carbon-based composite materials for capacitive deionization Water desalination via capacitive deionization: what is it and what can we expect from it Anion-selective redox electrodes: electrochemically mediated separation with heterogeneous organometallic interfaces Asymmetric Faradaic systems for selective electrochemical separations Redox-electrodes for selective electrochemical separations Polyvinylferrocene for noncovalent dispersion and redox-controlled precipitation of carbon nanotubes in nonaqueous media Removal and recovery of Cr(VI) from wastewater by maghemite nanoparticles Electrosorption of chromium ions on carbon aerogel electrodes as a means of remediating ground water Spectroscopic investigation of Cr(III)- and Cr(VI)-treated nanoscale zerovalent iron Kinetics of chromate reduction by ferrous iron Electrochemical reduction of dilute chromate solutions on carbon felt electrodes A grid-based Bader analysis algorithm without lattice bias Charging/discharging nanomorphology asymmetry and rate-dependent capacity degradation in Li-oxygen battery Liquid cell transmission electron microscopy observation of lithium metal growth and dissolution: root growth In situ observation of random solid solution zone in LiFePO4 electrode and solvent transfers into a poly(vinylferrocene)-modified electrode Counter-ion specific effects on charge and solvent trapping in poly(vinylferrocene) films The effect of composition of a ferrocene-containing redox polymer on the electrochemistry of its thin-film coatings on electrodes In situ ellipsometric measurements of polybipyrazine Electrochemical Methods: Fundamentals and Applications 2nd edn (Wiley Use of neutron reflectivity to measure the dynamics of solvation and structural changes in polyvinylferrocene films during electrochemically controlled redox cycling Investigation of ion and solvent transport accompanying redox reactions of polyvinylferrocene films using an in situ electrochemical quartz crystal microbalance technique Film mass and volume changes accompanying redox-driven solvent and salt transfer during redox switching of polyvinylferrocene films Efficient iterative schemes for ab initio total-energy calculations using a plane-wave basis set From ultrasoft pseudopotentials to the projector augmented-wave method A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu Implicit solvation model for density-functional study of nanocrystal surfaces and reaction pathways Accuracy of exchange-correlation functionals and effect of solvation on the surface energy of copper Download references We thank Elaine Lee and Liruonong Zhang for their help and assistance in preparing the electrodes and Kai-Jher Tan for his assistance with the ICP measurements We thank David Allan Bloore for his help with molecular visualization of the DFT results Arthur Pelton for the kind assistance in pointing us to the online FactSage Module for E-pH calculations Present address: Department of Materials Science and Engineering guided the project by providing scientific input and supervision carried out the materials synthesis and characterization performing the in situ electrochemical TEM imaging performed the electrochemical separation tests and liquid assays performed the electronic structure calculations and associated analysis wrote the paper with input and revisions from all authors The authors declare no competing interests Publisher’s note: Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41467-018-07159-0 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Environmental Science and Pollution Research (2024) Sign up for the Nature Briefing newsletter — what matters in science Seriola farms run by Kurose Suisan and Global Ocean Works in Japan have become the first in the world to earn Aquaculture Stewardship Council (ASC) certification for the species Kurose Suisan, operated by the Nissui Group network, has been producing Seriola since 2004 under the brand, Kurose Yellowtail, from its farms sites located in Kushima, in the Miyazaki prefecture in the south of Japan. Global Ocean Works, based in Tarumizu City, Kagoshima Prefecture Japan, was established in 2009 with a focus on processing and sale of ‘hamachi' yellow tail. “It is with great pleasure that we welcome Kurose Suisan and Global Ocean Works to the growing family of ASC certified farms. I would like to offer my personal congratulations to all those involved in becoming the first Seriola producers to achieve the ASC standard,” said Chris Ninnes, CEO of ASC. Volume 11 - 2024 | https://doi.org/10.3389/fmed.2024.1380236 This article is part of the Research TopicCase Reports in Pulmonary Medicine 2023View all 15 articles is an autoinflammatory granulomatosis disease characterized by a distinct triad of skin and eye disorders similar to those of sarcoidosis but the lung involvement frequently observed in sarcoidosis are rare Granulomas from patients with BS displayed a distinct morphology indicating an exuberant chronic inflammatory response Patients with BS may have granulomatous lung lesions To determine whether therapeutic intervention is needed for lung lesions examining transbronchial lung cryobiopsy specimens and accumulating cases of BS with lung involvement could be contributed to improving BS management in the future Juvenile sarcoidosis, known as Blau syndrome (BS), is an autoinflammatory granulomatosis disease characterized by a distinct triad of skin, joint, and eye disorders (1). Nucleotide-binding oligomerization domain 2 (NOD2) has been identified as the gene responsible for this disease, and the autosomal dominant or sporadic gene mutations induce autoactivation of nuclear factor kappa B (2) The symptoms of BS are similar to those of sarcoidosis, but the lymphadenopathy and lung involvement frequently observed in sarcoidosis are rare, and the first case of interstitial lung disease in BS was reported in 2007 (3). In the present case, the patient had early-onset BS at the age of 2 years, and the M513T mutation in the NOD2 was identified and previously reported (2) Transbronchial lung cryobiopsy (TBLC) was performed on the tiny but diffuse granular shadows in the lungs and pathological examination of the specimens confirmed the granulomas There have been very few reports of lung lesions in BS no report has pathologically proven granulomas in the lung and adult-onset lung granulomas in BS Herein, a 22-years-old man was referred to our department for the examination of extensive bilateral lung granular shadows. On admission to receive TBLC, the vital signs of the patient were body temperature of 36.3°C, regular pulse of 75 bpm, SpO2 of 99% in room air, and auscultation for the heart and lungs was normal. He had been having dry cough for 3 months before bronchoscopic examination (the day X-3M) (Figure 1) and painful swelling of the right knee and right wrist and diffuse tiny scaly erythematous in abdomen back and extremities of cutaneous with mild pigmentation X indicated the day of bronchoscopic examination was performed and X-10M indicated the day of 10 month (M) before the day of bronchoscopic examination was performed Changes in serum levels of angiotensin converting enzyme (ACE) and soluble interleukin-2 receptor (sIL-2R) were in blue line and red-dot line (A) Chest computed tomography using the lung window setting shows diffuse ground-glass shadows presumed to be fine nodules in the bilateral upper lobes (D) Chest computed tomography using the mediastinum window setting shows minor swelling of mediastinal lymph nodes The patient was treated with prednisolone (5–10 mg/day) and human IgG1 monoclonal antibody specific for tumor necrosis factor-α (TNF-α adalimumab) at a dose of 40 mg once every two weeks which was introduced 2 years ago to treat arthritis and reduce the adverse effects of steroids Differential diagnosis for granular shadows in the bilateral lungs suggested fungal and acid-fast bacillus infections (A) Histological examinations of the lung tissue obtained by transbronchial lung cryobiopsy show non-caseating epithelioid granulomas scattered around the alveolar septum vessels and large complex of granulomas without inter granulomatous sclerosis at X30 magnification (B) Prominent epithelioid cells and multinucleated giant cells around bronchioles are indicated by black arrows in the panel at X200 magnification but there was no history of inhalation of these antigens in present case Examination with polarized light to rule out foreign body was not done on specimens when pulmonary symptoms and granulomas appear again it may be useful to monitor the changes in ACE and sIL-2R levels and consider the use of immunosuppressive agents if the pulmonary lesions worsen Unlike sarcoidosis, the spontaneous remission of BS is rare, and the syndrome eventually leads to sequelae such as blindness and joint contractures. Thus, early diagnosis are considered necessary, even in the lungs. The diagnostic rate was reported to be 37–90% for transbronchial lung biopsy (TBLB) and 80–92% for TBLC in sarcoidosis, a major disease presenting with granulomatous lesions of the lungs (13, 14) The similarities and differences between pulmonary granulomatous lesions in BS and sarcoidosis remain unresolved accumulating knowledge from pathological examination on TBLC specimens would be useful in determining the timing of therapeutic intervention for lung lesion and that can contribute to improving management for BS in the future further inquiries can be directed to the corresponding author Written informed consent was obtained from the patient for the publication of any potentially identifiable images or data included in this article The author(s) declare that no financial support was received for the research The author(s) declared that they were an editorial board member of Frontiers This had no impact on the peer review process and the final decision All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher PubMed Abstract | Crossref Full Text | Google Scholar Clinical characteristics and treatment of 50 cases of Blau syndrome in Japan confirmed by genetic analysis of the NOD2 mutation Interstitial pneumonitis in Blau syndrome with documented mutation in CARD15 Morphologic and immunohistochemical characterization of granulomas in the nucleotide oligomerization domain 2-related disorders Blau syndrome and Crohn disease 5. Japan Society of Sarcoidosis and other Granulomatous Disorders. Guide to Sarcoidosis Clinical Practice. (2020). Available online at. https://www.jssog.com/wp/wp-content/themes/jssog/images/system/guidance/1-3-1.pdf Google Scholar PubMed Abstract | Crossref Full Text | Google Scholar Role of the NOD2 genotype in the clinical phenotype of Blau syndrome and early-onset sarcoidosis The role of nucleotide-binding oligomerization domain-like receptors in pulmonary infection A novel mutation in early-onset sarcoidosis/Blau syndrome: an association with Propionibacterium acnes Advance in pathogenesis of sarcoidosis: triggers and progression Potential Benefits of TNF targeting therapy in Blau syndrome a NOD2-associated systemic autoinflammatory granulomatosis is a potential treatment for Blau syndrome Role of bronchoscopic techniques in the diagnosis of thoracic sarcoidosis Diagnostic yield and safety of transbronchial cryobiopsy in sarcoidosis Ishida K and Niho S (2024) Pulmonary granulomas confirmed in Blau syndrome using TBLC specimens: Case report Copyright © 2024 Shimizu, Kushima, Tanaka, Takemasa, Ishida and Niho. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Yasuo Shimizu, eWFzdW8tc0Bkb2treW9tZWQuYWMuanA= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish. This study aimed to develop an efficient interview sheet during pregnancy and screening tool to identify pregnant women needing social support at obstetric institutions. Moreover, we investigate the perinatal factors associated with the Edinburgh postnatal depression scale (EPDS). We created the NEW interview sheets and screening tools during the first and the second trimester. Future studies are needed to validate these screening tools. Volume 3 - 2022 | https://doi.org/10.3389/fgwh.2022.921361 Background: This study aimed to develop an efficient interview sheet during pregnancy and screening tool to identify pregnant women needing social support at obstetric institutions we investigate the perinatal factors associated with the Edinburgh postnatal depression scale (EPDS) Methods: This prospective cohort study was conducted at three medical institutions that commonly encounter cases with social issues Pregnant women were assessed using an interview sheet at the first visit (n = 678) at approximately 28 weeks gestation (n = 495) 36 weeks gestation (n = 296) and the postpartum period (n = 822) We investigated the important items identified on the new screening questionnaire (NEW interview sheets) for women needing social support The items on the interview sheet were scored by multiple linear regression analysis and the cutoff values were calculated using the receiver operating characteristic curve The association between perinatal factors and EPDS was assessed using multiple logistic regression analyses Results: The study included 166 cases for which all NEW interview sheets for all periods were available NEW interview sheets and stepwise screening tools during the first and second trimester were developed in which 2.5% of pregnant women were identified as requiring social support The factors associated with EPDS ≧ 9 were “Women who felt confused/troubled or did not feel anything to be pregnant” (adjusted odds ratio [aOR]: 6.51 95% confidence interval [CI]: 1.62–26.15) “Maternal mental disorder” (aOR 4.38; CI 1.06–18.10) “Consultation request at first visit” (aOR 3.22; CI 1.09–9.45) and “Women who have difficulty or anxiety about pregnancy during the second trimester” (aOR 3.14; CI 1.29–7.67) Conclusions: We created the NEW interview sheets and screening tools during the first and the second trimester Future studies are needed to validate these screening tools Understanding social and medical risk factors is an essential part of abuse prevention Identifying social risk factors at the time of pregnancy and initiating support for pregnant women who need social support may help reduce child maltreatment Although there are many public health centers that identify pregnant women who need social support through questionnaires and interviews when issuing the Maternal and Child Health Handbook success is limited due to few opportunities for contact with pregnant women pregnancy health checkups at obstetric institutions are scheduled at least 14 times where the mother's health condition is assessed and a medical examination and health guidance are provided Health guidance addresses the mental health of pregnant women and relieving their anxiety about pregnancy about half of the delivery facilities in Japan are private obstetric clinics some of which are inadequate for resolving social and psychological problems in the affected population This study aimed to develop a screening tool for detecting pregnant women in need of support that can be used in health guidance at all facilities We investigated the items from the NEW interview sheets that were considered important by women identified to be in need of social support The primary outcome was to develop an available interview sheet during pregnancy and the screening tool to detect pregnant women in need of support in collaboration with a public health center A secondary outcome was to investigate the perinatal factors associated with EPDS This was a prospective cohort study conducted at three medical institutions that were familiar with social issues such as unmarried mothers maternal mental disorder or teenage pregnancies affecting pregnancy and childcare outcomes Inclusion criteria in the study were pregnant women managed at the three medical institutions who consented to the study information was collected from face-to-face interviews impressions based on behavior and actions such as poor comprehension medical information and original questionnaires including the NEW interview sheets were distributed Using information other than the NEW interview sheets pregnant women in need of administrative cooperation were selected by conferences at Osaka Women's and Children's Hospital and Seibo Hospital and by nurses specializing in maternity nursing at Showa University The members of the conference at Osaka Wemen's and Children's Hospitalwere nurses while the members at Seibo Hospital were nurses Standardized partial regression coefficients were calculated by multiple linear regression analysis to refine and score each item on the NEW interview sheet Scores were calculated by multiplying the standardized partial regression coefficient by 100 and rounding it off to the closest whole The cutoff value was calculated by the receiver operating characteristic (ROC) curve The variance inflation factor was calculated using regression analysis to confirm multi-collinearity in the multivariate analysis The association between perinatal factors and EPDS was assessed using multiple logistic regression analysis All statistical analyses were performed using SPSS Statistics ver Two-sided P-values of <0.05 were considered statistically significant This study complied with all the relevant national regulations and the tenets of the Helsinki Declaration This research was approved by the Ethics Review Board of the University of Yamanashi (approval number 1663 Written informed consent was obtained from all study subjects At the time the NEW interview sheets from the three medical institutions were mailed to the University of Yamanashi and names and IDs for each hospital were deleted The matching forms of research IDs and hospital-specific IDs were managed at each institution we investigated socially high-risk pregnant women who were supported by their respective obstetric institutions as well as collaborating with a public health center 2% of pregnant women in need of support required collaboration with a public health center and 17% of the pregnant women were at high-risk of needing social support 6% of pregnant women in need of support required collaboration with public health centers and it was highest at 23% in the postpartum period There was a change in the support status during pregnancy cooperation with public health centers was started but later changed to support at the respective medical institutions or some cases in which support was no longer needed There were also 13 cases presenting without problems during pregnancy Support status change during pregnancy and the postpartum period There were cases in which the support status changed during the gestational period †Hospital support: socially high-risk pregnant women who were supported by their respective obstetric institutions ‡Administrative cooperation: pregnant women in need of support to require collaboration with public health center The number of pregnant women in need of support by the public health center The screening tool used at the first visit Pregnant women with score of 22 points or more were selected as STEP-1 pregnant women are narrowed down as STEP 2 and 3 according to the items on the interview sheet at first visit The multiple linear regression analysis at first visit The screening tool used during the second trimester Pregnant women with score of 14 points or more were selected as STEP-1 pregnant women are narrowed down as STEP 2 and 3 according to the items on the interview sheet during the second trimester The multiple linear regression analysis during the second trimester Table 5 shows the results of the multiple linear regression analysis during the third trimester Each item on the NEW interview sheets was scored and a cutoff value of 7 points was calculated using the ROC curve The multiple linear regression analysis during the third trimester The factor “no family and social support” (n = 1) and “ illegal drug use by the mother(n = 4) and partner” (n = 3) at the first visit and “no family and social support,”(n = 2) “alcohol use,” (n = 2) and “less or unscheduled pregnancy health checkups”(n = 1) during the second trimester were excluded due to their small number “Maternal mental disorder”(aOR 4.38 “Consultation request at first visit” (aOR 3.22 and “Women who have difficulty or anxiety about pregnancy during the second trimester” (aOR 3.14 The factor “less or unscheduled pregnancy health checkups” (n = 3) during the third trimester was excluded due to the small number of cases and no factor associated with EPDS was found Relationship between EPDS ≧ 9 and each item on the NEW interview sheets Specified expectant mothers are defined in the Child Welfare Act as “pregnant women who are recognized as being in particular need of support during pregnancy with regard to postpartum care.” A specified expectant mother is determined by the health center This study aims to detect pregnant women in need of support in collaboration with health centers cases corresponding to specified pregnant women we believe that the detection rate of pregnant women in need of social support using this screening tool is reasonable The screening tool was created with the goal of being able to detect women even in obstetric clinics that were not familiar with social issues it will be necessary to verify whether these NEW interview sheets and screening tools can appropriately identify pregnant women in need of social support and we are planning to create a system that can automatically identify pregnant women in need of social support by inputting the results of the NEW interview sheets The strength of this study is a prospective survey conducted in several obstetric institutions that are specialized in addressing social issues and various criteria were used to determine the detection of pregnant women in need of social support considering the possibility of changes in the mother's and family's condition during pregnancy and background factors that may become apparent through the establishment of a relationship between the mother and the obstetric institution NEW interview sheets and screening tools were developed that included items tailored to each period and items common to all periods less than half of the cases had a complete NEW interview sheets for all time periods This was because two of the three facilities in this study handle many medically high-risk pregnancies which may result in first visits at various times the number of patients who were referred in the second trimester and later due to medical risks such as fetal growth retardation or threatened premature birth means that a larger percentage of patients do not receive the NEW interview sheets especially in the early and middle trimester of pregnancy although it had been reported that a late first visit is associated with pregnant women in need of social support This was because the study includes many cases in which the first visit was made after the second trimester due to medical risks this study was conducted up to one month after childbirth and the relationship with the need for support at a public health center after that was unknown Although it would be desirable to collate the data with information from the public health center if there was an actual fear of child maltreatment several months after the birth it was difficult to obtain the data from the public health center from the viewpoint of personal information protection it is considered necessary to create an environment where medical institutions and government agencies can collaborate to collect information in Japan we developed the NEW interview sheets and the stepwise screening tools during the first and the second trimester to detect pregnant women in need of support to require collaboration with a public health center We plan to further validate these NEW interview sheets and screening tools by increasing the number of participating obstetrics clinics The raw data supporting the conclusions of this article will be made available by the authors The studies involving human participants were reviewed and approved by he Ethics Review Board of the University of Yamanashi (approval number 1663 Written informed consent to participate in this study was provided by the participants’ legal guardian/next of kin and was a major contributor in writing the manuscript and MK analyzed and interpreted the patient data YM aided in planning the research and writing the paper ZY aided in planning the research and interpreted the patient data This study was supported by Health and Labour Sciences Research Grants (19DA1003) The funder of this research did not interfere with the design We would like to express our gratitude to the outpatient staff of the Osaka Women's and Children's Hospital and Showa University Hospital for their cooperation in this study Child maltreatment in the “children of the nineties": a cohort study of risk factors Perinatal determinants of child maltreatment in Japan The long-term health consequences of child physical abuse and neglect: a systematic review and meta-analysis Child maltreatment and adolescent mental health problems in a large birth cohort and health outcomes associated with child abuse and neglect Results of Investigation on Child Abuse Deaths and Number of Child Abuse Consultation Characteristics of socially high-risk pregnant women and children's outcomes Child maltreatment in the “children of the nineties": a cohort study of risk Factors Effects of primary prevention of child abuse that begins during pregnancy and immediately after childbirth CrossRef Full Text | Google Scholar Synergistic effects of unintended pregnancy and young motherhood on shaking and smothering of infants among caregivers in Nagoya city Postnatal depression in Japanese women who have given birth in England Selection criteria and progress of mothers require cares in our hospital Google Scholar The background of specified expectant mothers in our institution Google Scholar Multicentre prospective study of perinatal depression in Japan: incidence and correlates of antenatal and postnatal depression Effects of exercise-based interventions on postpartum depression: a meta-analysis of randomized controlled trials Preventing postpartum depression: a meta-analytic review Universal prevention of distress aimed at pregnant women: a systematic review and meta-analysis of psychological interventions An integrated community mental healthcare program to reduce suicidal ideation and improve maternal mental health during the postnatal period: the findings from the Nagano trial Impact of intention and feeling toward being pregnant on postpartum depression: the Japan environment and Children's Study (jecs) Yamamoto T and Yamagata Z (2023) Developing an obstetric care screening tool to improve social support access for pregnant women: A prospective cohort study Received: 19 April 2022; Accepted: 26 December 2022;Published: 1 February 2023 © 2023 Kawaguchi, Shinohara, Akiyama, Kushima, Matsuda, Yoneyama, Yamamoto and Yamagata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Haruna Kawaguchi aGFydW5hQHdjaC5vcGhvLmpw Specialty Section: This article was submitted to Maternal Health a section of the journal Frontiers in Global Women's Health National Report MATSUE--Now overgrown with weeds and vegetation the decaying ruins here offer stark testimony to the extreme attempts Japan made in a last-ditch effort to avoid defeat in the waning months of World War II The site on uninhabited Kushima island in the Sea of Japan was apparently intended to serve as a base for Koryu-class midget submarines developed for special attacks to defend mainland Japan Although construction of the facility was long known to experts through Imperial Japanese Navy records the site had basically been lost to history until a citizens group made a first-hand inspection of the island in October a group formed last year to host lectures on modern history and film screening events located northeast of Shichirui Port in the capital of Shimane Prefecture They came across a tunnel three to four meters high 3.5 meters wide and 14 meters long that appeared to have been dug by hand with pickaxes or other tools near a beach on the southern part of the island a halfway dug bunker and the remains of a well According to a list compiled by the Maizuru Naval Facilities Department three “underwater special attack bases” were planned for Koryu submarines: a deployment base In addition to Matsue’s Shichirui district The number of the submarines planned for deployment remains unknown a former prefectural government official who serves as a coordinator for the citizens group said entries in the list suggest the passageway was a communications tunnel and the stone wall was the ruins of the barracks Construction apparently began in or around June 1945 just before Japan's defeat but the structures were never completed and left to decay after the war “They were overgrown with vegetation and weeds but I think that the plan was to make the whole area around the beach into a base,” said Wakatsuki but I think this is the first time to see them on site.” a five-man midget submarine equipped with two torpedo tubes and a diesel generator was a special weapon developed for the final battle for the mainland According to “Kaigun Gunsenbi: Kaisen-igo,” a publication on the Navy’s military equipment published by the Office of War History at the National Defense College (forerunner of the National Institute for Defense Studies) About 100 were built by the end of the war Crew members trained at the so-called P Base in the Ourasaki district of Kure Sasebo in Nagasaki Prefecture and elsewhere In “Shichirui Kyoiku Hyakunen-shi” (100-year history of education in Shichirui) published in 1975 who served as principal of a local public elementary school between 1945 and 1949 recalls: “When it was decided to build a naval special attack base (human torpedoes) on Kushima at short notice aviator trainees from the Miho Naval Air Corps came here for tunnel excavation work every day via the Shichirui-toge pass.” The school’s auditorium and one-story classroom were requisitioned by order of the civil engineering group at the Maizuru Naval Port to use as accommodation for aviator trainees But Wakatsuki suspects that Takai might have had the wrong idea about the “human torpedoes,” which were known by the name of the Kaiten because the Navy would have kept details about the base confidential which is something that can only be taken as a joke today there were people who took it seriously,” Wakatsuki said “It matters a lot to find a clue that shows a relation to the final battle for the mainland in Shimane Prefecture.” Wakatsuki’s group plans to publish a book in January featuring more than 400 war-related ruins in Matsue Izumo and Unnan in Shimane Prefecture with photos and maps The submarine base on Kushima will be included Mix of cultures helped many in wartime choose life over suicide Young soldier’s hand shook as he wrote kamikaze mission orders Wartime letter shows secrets of suicide torpedo plan had leaked An earthquake measuring an intensity of lower 6 on the Japanese seismic scale of 7 occurred in southern Miyazaki Prefecture at around 4:40 p.m according to the Japan Meteorological Agency please disable the ad blocking feature and reload the page This website uses cookies to collect information about your visit for purposes such as showing you personalized ads and content By clicking “Accept all,” you will allow the use of these cookies Users accessing this site from EEA countries and UK are unable to view this site without your consent Kushima and Miyakonojo in the prefecture as well as the town of Osaki in Kagoshima Prefecture saw an intensity of upper 5 The focus was at a depth of about 30 kilometers Tsunami advisories were issued for Miyazaki The first wave was expected to reach Ehime Prefecture at around 5:10 p.m Nankai Trough Earthquake Evacuation Shelters Open across 4 Prefectures in Japan as Advisory Issued; Some Have Already Evacuated Monitoring of Nankai Trough Heightened but No Abnormal Changes Observed; People Urged to Reexamine Disaster Preparedness Earthquake Information Scarce for Foreign Tourists; Govt Should Provide Information to Tourists, Expert Says Nankai Trough Megaquake Tsunami could Hit in 2 Minutes; Japan Authorities Urge Caution after Recent Earthquake Our weekly ePaper presents the most noteworthy recent topics in an exciting © 2025 The Japan News - by The Yomiuri Shimbun Metrics details we identified a subpopulation of schizophrenia (SCZ) showing increased levels of plasma pentosidine a marker of glycation and oxidative stress its causative genetic factors remain largely unknown it has been suggested that dysregulated posttranslational modification by copy number variable microRNAs (CNV-miRNAs) may contribute to the etiology of SCZ an integrative genome-wide CNV-miRNA analysis was performed to investigate the etiology of SCZ with accumulated plasma pentosidine (PEN-SCZ) The number of CNV-miRNAs and the gene ontology (GO) in the context of miRNAs within CNVs were compared between PEN-SCZ and non-PEN-SCZ groups Gene set enrichment analysis of miRNA target genes was further performed to evaluate the pathways affected in PEN-SCZ We show that miRNAs were significantly enriched within CNVs in the PEN-SCZ versus non-PEN-SCZ groups (p = 0.032) the dysregulated neurodevelopmental events in the two groups may have different origins gene set enrichment analysis of miRNA target genes revealed that miRNAs involved in glycation/oxidative stress and synaptic neurotransmission especially glutamate/GABA receptor signaling this is the first genome-wide CNV-miRNA study suggesting the role of CNV-miRNAs in the etiology of PEN-SCZ through effects on genes related to glycation/oxidative stress and synaptic function Our findings provide supportive evidence that glycation/oxidative stress possibly caused by genetic defects related to the posttranscriptional modification may lead to synaptic dysfunction targeting miRNAs may be one of the promising approaches for the treatment of PEN-SCZ An integrative genetic and epigenetic analysis would accelerate the elucidation of the etiology the genetic and epigenetic factors that account for the accumulation of pentosidine and their contribution to this phenotype have not yet been fully elucidated CNV-miRNA analysis to investigate the genetic factors associated with SCZ with enhanced glycation/oxidative stress and to provide novel insights into the etiology of PEN-SCZ focusing on the disturbance of posttranscriptional modification caused by CNV-miRNAs the average length of total CNVs in PEN-SCZ versus non-PEN-SCZ groups was compared the average number of genes within CNVs was obtained the total number of miRNAs within CNVs was compared between the two groups the number of patients harboring CNV-miRNAs was determined the average number of miRNAs per patient was compared the number of patients with rates of miRNA genes per total genes within CNVs greater than 50% was compared between PEN-SCZ and non-PEN-SCZ groups with respect to the in silico prediction of miRNA target genes using miRWalk the p values were calculated from a random-forest-based approach using TarPmiR for miRNA target site prediction A p value of <0.05 was considered significant The genotype relative risk was calculated from the OR obtained using the Fisher’s exact test In this study, we compared the number of CNV-miRNAs between SCZ patients with high plasma pentosidine levels (PEN-SCZ) and those without the accumulation of plasma pentosidine (non-PEN-SCZ). Based on the power analysis, the expected power to detect significant CNV-miRNAs with an OR of 5.0 was 0.638 (Supplementary Table S1) we compared the rate of miRNA genes per total genes within CNVs in PEN-SCZ versus non-PEN-SCZ defined as a rate of miRNA genes in genes within CNVs >50% was significantly higher in PEN-SCZ versus non-PEN-SCZ (p = 0.032) A comparison of the GO properties of miRNAs within CNVs between PEN-SCZ and non-PEN-SCZ patients suggested that miRNAs involved in “midbrain dopamine neuron differentiation” (14.3%; 2.4 × 10−7) and “neuron–neuron synaptic transmission” (20.0%; 1.2 × 10−7) were likely to be affected in PEN-SCZ (Supplementary Table S3) “olfactory bulb interneuron differentiation,” was affected in non-PEN-SCZ (9.1%; 3.2 × 10−4) suggesting that different molecular mechanisms may be behind the etiology of the two SCZ subtypes Although the sample size and the number of observations were small, several notable CNV-miRNAs were identified in patients with PEN-SCZ with pentosidine plasma levels higher than 100 ng/mL in this study (Table 2) The main notable CNV-miRNAs are presented below including DRD2 and MECP2 that encode dopamine receptor D2 and methyl-CpG binding protein 2 the putative target genes of miR-4300 were also linked to “serotonin receptor signaling” one of the main targets of typical and atypical antipsychotic drugs we examined the frequency of CNV-miRNAs in SCZ with and without accumulated plasma pentosidine including the GO properties regulated by those miRNAs Gene set enrichment analysis in the context of miRNA target genes found in rare CNVs was further performed for a better understanding of the molecular pathogenesis of PEN-SCZ we observed that PEN-SCZ harbored 9.8-fold more miRNA-enriched CNVs than non-PEN-SCZ possibly affecting different neuronal developmental events analyses of individual CNV-miRNAs in PEN-SCZ suggested that miRNAs related to glycation/oxidative stress especially glutamate/GABA receptor signaling may be affected several notable CNV-miRNAs of interest were observed and suggestive evidence potentially linking glycation/oxidative stress and synaptic function via CNV-miRNAs was modestly disclosed we hypothesize this might be due to the high number of CNV-miRNA genes affecting multiple pathways One fact potentially supporting this hypothesis is the deletion of MIR4300: the expression of DRD2 making this patient resistant to the current antipsychotic drugs which mainly block DRD2 supports this notion that neuronal developmental events may be affected via CNV-miRNAs in SCZ we found that the origins of the phenotype appeared to be different between PEN-SCZ and non-PEN-SCZ which may also be behind the resistance to treatment with antipsychotic drugs in PEN-SCZ we identified several interesting copy number variable miRNAs (CNV-miRNAs) in the SCZ subtype characterized by accumulated plasma pentosidine targeting recurrent SCZ risk genes such as CACNA1C and DRD2 was entirely deleted in the patient with SCZ who showed extremely high plasma pentosidine associated with oxidative stress and synaptic function including glutamate and GABA receptor signaling were identified in other SCZ patients with high plasma pentosidine two patients with PEN-SCZ shared the CNV-miRNA possibly involved in glutamate secretion as per the gene set enrichment analysis Our results may indicate that the miRNAs involved in glycation and synaptic function are disrupted by CNVs in SCZ patients with the enhanced glycation and oxidative stress subtype it is particularly interesting that enzymes involved in glucose metabolism and oxidative stress were both targeted by the CNV-miRNAs in SCZ patients with high plasma pentosidine speculate that the shared miRNA target genes are related to NMDA receptor signaling molecules while the other target genes may contribute to generate the heterogeneous phenotypes observed in SCZ GO and gene set enrichment analyses may help to understand the pathway affected by the rare CNV-miRNAs the reason why we performed them in this study our analyses included not only validated target genes for the miRNAs but also putative genes The need for the prediction of miRNA target genes using an in silico computational approach is another limitation of the present study the cause of the increase in plasma pentosidine may be polygenic in nature and attributed to the sum of small individual effects Although miR-4300 was identified as only one gene affected by CNVs other genes in CNVs not coding for miRNAs coexisted suggesting that the etiology of SCZ is associated with a combined effect of CNVs on miRNAs and other genes the possibility that other genetic and epigenetic factors such as methylation was not excluded although this is a preliminary study with a limited sample size our integrative genome-wide CNV-miRNA analysis is the first to provide suggestive evidence that miRNA-enriched CNVs are more prevalent in PEN-SCZ versus non-PEN-SCZ disrupting different neuronal developmental events the analysis of individual CNV-miRNAs observed in PEN-SCZ implicated a possible regulatory link between glycation/oxidative stress and synaptic dysfunction in SCZ patients with enhanced glycation/oxidative stress targeting miRNAs within CNVs to restore the aberrant synaptic function may be a promising strategy for the development of personalized treatments for SCZ patients with enhanced glycation/oxidative stress Disconnection and cognitive dysmetria in schizophrenia The origin of schizophrenia: genetic thesis Rare chromosomal deletions and duplications increase risk of schizophrenia Common polygenic variation contributes to risk of schizophrenia that overlaps with bipolar disorder Common variants conferring risk of schizophrenia Association of DNA methylation differences with schizophrenia in an epigenome-wide association study Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations/diseases genetic effect 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drug target selection prioritization and validation of drug mechanism Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies the host gene of microRNA MIR4300 is associated with progression of adolescent idiopathic scoliosis Genome-wide association study identifies 14 previously unreported susceptibility loci for adolescent idiopathic scoliosis in Japanese Validation of schizophrenia-associated genes CSMD1 Psychiatric risk gene Cacna1c determines mitochondrial resilience against oxidative stress in neurons DJ-1 cooperates with PYCR1 in cell protection against oxidative stress Parkinsonism-associated protein DJ-1/Park7 is a major protein deglycase that repairs methylglyoxal-and glyoxal-glycated cysteine The glyoxalase system in health and disease From revolution to evolution: the glutamate hypothesis of schizophrenia and its implication for treatment NMDA receptor hypofunction for schizophrenia revisited: perspectives from epigenetic mechanisms a novel family of postsynaptic density proteins that binds to the NMDA receptor/PSD-95/GKAP complex and cortactin The role of advanced glycation end products in aging and metabolic diseases: bridging association and causality Glyoxalase 1 increases anxiety by reducing GABA A receptor agonist methylglyoxal Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia The interneuron energy hypothesis: implications for brain disease Measuring and estimating the effect sizes of copy number variants on general intelligence in community-based samples Download references We are grateful for the expert technical assistance of Nanako Obata We especially thank Hiroko Yuzawa at Tokai University School of Medicine for the measurement of pentosidine We are grateful to all of the families who took part in this study This work was supported by JSPS KAKENHI grant numbers 17H05090 and 15K19720 (Dr Yoshikawa); the Japan Agency for Medical Research and Development (AMED) under grant numbers JP20km0405216 Itokawa); the Uehara Memorial Foundation (Dr Department of Psychiatry and Behavioral Sciences Tokyo Metropolitan Institute of Medical Science Nagoya University Graduate School of Medicine Research Center for Genome & Medical Sciences performed the experimental work and undertook the statistical analysis All authors participated in the collection of blood samples from patients and helped complete this manuscript All authors have approved the final version of the manuscript Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41398-021-01460-1 Sorry, a shareable link is not currently available for this article. Brunno Braga•Aug 25 Daughter of a Japanese father and an Afro-Brazilian mother Sayuri Koshima is an Afro-Japanese woman living in Salvador With a law degree and also working as a tour guide she has always been viewed as the exotic girl because of her Asian eyes “My heart for sure is 50% Japanese and 50% Afro-brazilian,” Kushima told Travel Noire Salvador, in Brazil, is known worldwide for being the most representative city of the African continent in the Americas. With a population of nearly 3 million people, over 80% of Salvador’s population identifies as Afro-Brazilian The African influence can be seen all over the city through its cuisine one can only guess what it’s like to be an Afro-Japanese person in this Afrocentric Utopia Latin America’s top business hub and land of the largest Japanese community outside Japan when I had a close relationship with my Japanese family I worked for 10 years for a Japanese Bank.” she decided it was time to strengthen her African roots especially through going to Candomblé ritual (an Afro-Brazilian religion originally from Yoruba culture) Learning more about her African heritage made Koshima feel stronger taking tourists to historic places in Salvador and teaching them about Afro-Brazilian history in the country “Being an Afro-Japanese woman in Salvador catches my clients by surprise Most of them have no idea how big the Japanese community is in Brazil After Kushima’s father died, she decided to establish a strong connection to her Japanese roots visiting Japan for the first time Landing in Japan was a very revealing experience I understood that I belong there as much as I belong to Brazil everything made me remember my grandmother’s house and my father No one there recognized me as a Japanese woman “Okinawa is my favorite place in Japan Sayuri wants to visit West Africa to feel the same experience she had visiting Japan “The Afro tours that I offer in Salvador give me a lot of experiences I will be visiting West Africa for another experience to help connect me to my roots but I need to really feel our Motherland in West Africa You can follow more of Sayuri Koshima’s journey via her Facebook page a free daily newsletter that features the best of travel and guides to the cities you love from a new point of view — yours you agree to our terms of service and privacy policy Queen Elizabeth Once Stepped In To Prevent Snoop Dogg From Being Banned From The UK United Airlines Flight Attendant's Armrest Announcement Sparks Social Media Frenzy ‘Basketball Wives’ Star Mehgan James Speaks Out About Popular Bahamas Island With Flesh-Eating Bacteria After Friend Loses Leg Chaos Erupts After Ethiopian Airlines Passenger Forced To Give Up Seat For Minister Paramount+'s 'MobLand' has rapidly garnered a wide audience thanks to its fascinating characters and gorgeous scenic backdrops A 27-year-old Chinese student living in Japan was rescued twice from Mount Fuji within days – the second time after reascending for his phone The Haifeng is Taiwan’s first luxury dessert-themed train It redefines the afternoon tea experience with some Michelin-starred desserts is taking a step towards opening its doors to international travelers discovering these dishes is recognizing that the rice you're eating in Louisiana has a cousin in Lagos Miyazaki — A horse drive was held last month to conduct annual health checks on wild horses in a tourist spot in Cape Toi in Kushima The horses are of a breed called Misaki-uma an association that cares for the wild horses University of Miyazaki students and residents shouted and held bamboo sticks to guide the wild horses into a fenced area the gathered horses’ blood was drawn and medications were administered after which the horses were released back into the fields on the cape Misaki-uma horses are one of Japan’s native breed varieties and characterized by its low stature and large head Please view the main text area of the page by skipping the main menu. The page may not be displayed properly if the JavaScript is deactivated on your browser Japanese version Lifestyle The text and illustrations are all handwritten "It's too good..." Record of a trip to the northernmost remote island of Japan Video filmed by university students becomes a hot topic: "It's youth" 5 easy-to-participate social good events in Hokkaido [May 2025] "Amazing view..." It's like another world A photo taken in the "city of steel" Muroran is a hot topic: "It's overwhelming" "As long as the fish is tasty...?!" The welcome party for a new recruit from Hokkaido is too difficult "They're the kind of people who sprinkle salmon roe on top." "They're so cute!" I feel comforted by the baby goats growing up healthy on a farm in Hokkaido "What a cute creature" - A baby seal growing up quickly is soothing Seeing it moving around so hard makes people say "It's like an angel" and "Grow up big" Seasonal “news” of Hokkaido can be checked by category You can check the information of your “town” in one place Events” held throughout the province are easy to find and can be saved This page has been automatically translated by Google Translate service One of the best things about Tokyo is there’s always something new There are creative seasonal menus and pop culture collaborations that you can find only here new restaurants and even illuminations this November After the 3D Calico cat sensation in Shinjuku and the 3D Hachiko in Shibuya Harajuku joins the ranks with its own video billboard featuring adorable animals It’s a take on the “Town Musicians of Bremen,” a German folktale The billboard can be seen at the intersection of Takeshita Street and Meiji Street in Harajuku You can catch broadcasts daily from 10am to 9pm Coffee comes with a little bit more magic than usual in Tully’s this month The first part of the collaboration with the Harry Potter franchise started on October 28 with the second part dropping on November 4 There will also be special Tully’s cards from November 11 the coffee chain is selling food and drinks This includes festive mince pie-flavored lattes in original Hogwarts cups and Hedwig-shaped cup warmers The owl warmers can then be worn on the wrist such as Shepherd’s pie and milk tea to name but a few From accessories to coffee-related products like mugs and special coffee beans there’s also a wide range of themed items on sale Kushima Rose is a specialty store from Nagoya that offers the fragrance of roses in a range of edible varieties Following the successful popup store in Ginza Six (open until January 2023) Kushima Rose has opened another limited-time store on the seventh floor of Tokyu Plaza Shibuya from September 11 to July 2023 is passionate about pesticide-free flowers and their benefits The Kushima Rose store in Shibuya offers several beautiful rose lemonades and a rose-themed afternoon tea You can also buy products such as rose syrup and rose jam particularly at yokocho — alleys filled with tiny bars like Omoide Yokocho or Golden Gai There’s now also the Ryu no Miyako Inshokugai Shinjuku Higashiguchi Yokocho This yokocho with 17 different establishments erupts in saturated colors and a mix of traditional Japanese cultural elements and theme-park-style dragons and characters comfort food such as ramen and even a karaoke bar A post shared by Jean Jullien (@jean_jullien) This stylish department store curates some of the best art for its atrium space having featured big names such as Yayoi Kusama and Shiota Chiharu The newest art installation is “The Departure” by French artist Jean Jullien which began in October The artist is known for his cartoonish characters which have now become 3D and left the page This is his first large-scale public installation The metal sculptures are slated to be hanging in the Ginza Six atrium until the spring of 2024 others will rejoice at this early winter illumination event at Shibuya Sky The limited time event dubbed “Sparkling View” is the first of its kind and will take place from November 17 to December 25 The Sky Gallery on the 46th floor will be filled with mirror balloons in what is named the Sparkling Balloon Corridor a sparkling light tree will appear on the rooftop observation deck enhanced with a light and sound performance every 30 minutes after 7pm There are always new cafes and restaurants opening in Tokyo Anakuma Café opened in Harajuku in late October with a unique whimsical concept It’s a literal hole-in-the-wall that you get your coffee from and by a bear paw to boot The green storefront is unmanned so no human interaction is required One of the most popular Mexican cuisine restaurants in Tokyo, Los Tacos Azules is opening a new concept store in Ebisu it will be a nighttime version of Los Tacos Azules with a focus on seafood Japanese sake fans are excited about Eureka It is run by Marie Chiba who used to work at Gem by Moto 　滋賀県の三日月大造知事が広島県庁を訪れ、山根健嗣副知事と平和施策を巡って意見交換した。三日月知事は次世代に戦争や被爆の悲惨さを伝えるため被爆地との連携を強める.. 　今回の調査では、壁画制作が実現しなかった主な理由として、広島訪問から２年と経（た）たない間にヘリングが他界したことが挙げられるという結論に至った。５月１８日ま.. 　「核廃絶は使命。このままでは死ねない」。その決意を胸に、広島で被爆した金本弘さん（８０）＝名古屋市＝が４月３０日、米ニューヨークの国連本部に集った各国の外交官.. 　１９４６年５月１日。中国新聞社が雑誌「月刊中国」を創刊した。広島市上流川町（現中区）の本社で印刷。「雑誌と言へば中央と考へられてゐた旧観念を脱し、地方文化の昂.. 　いつからだろうか。喜びあふれる光景が大通りになじんできたのは。広島市中心部を東西に貫く平和大通りは今月、鶴見橋から新己斐橋までの約４キロが全通して６０年を迎え.. 　私は長崎で生まれ育ったが、反戦・反核に対する思いが絶えず心の中で燃えていたかといえばそうではない。平穏に、平凡に暮らしてきた。それでも、先人たちの話を聞きなが.. 　中村キース・ヘリング美術館で５月１８日まで開催中の「Ｋｅｉｔｈ　Ｈａｒｉｎｇ：　Ｉｎｔｏ　２０２５　誰がそれをのぞむのか」展は、ヘリングの幼少期を振り返ること.. 　１９６６年、１９歳で中学を卒業した川下ヒロエさん（７９）＝広島市東区＝はこの年、被爆者健康手帳を取得した。当時住んでいたのは北九州市。母兼子さん（２０１４年に.. 　国際社会は危機感を持ち、歯止めの議論に入るべきだ。スウェーデンのストックホルム国際平和研究所（ＳＩＰＲＩ）が、２０２４年の世界の軍事費支出を発表した。２兆７１.. 　動物文学で知られる椋鳩十（むくはとじゅう）に、おどろおどろしい題名の異色作がある。「地獄島とロシア水兵」だ。舞台は萩の沖合４５キロに浮かぶ見島。１２０年前の５.. 　全ての命を守るため―をテーマに掲げていた。ローマ教皇フランシスコによる６年前の来日である。被爆地広島、長崎のほか、地震・津波・原発事故という三重の災害に見舞わ.. 俳優の吉永小百合さんは、これまで胎内被爆者の芸者を演じた「夢千代日記」などに出演してきたほか、原爆詩朗読CD「第二楽章」を制作しています。中国新聞創刊１３０周年記念として、３編の朗読映像を公開します。(写真は三浦憲治氏撮影) 中国軍管区司令部で被爆した八木さんの革脚絆＝１９７３年、八木実さん寄贈（撮影・山田尚弘） Members of the committee for the Modern Language Festival are the following: Seated from left: Teresita Flores (MLF)—A Modern Language Festival presented by students enrolled in Chinese Spanish and Tagalog in the Division of Humanities College of Liberal Arts and Social Sciences at the University of Guam will be held on Saturday 2011 in the buildings of the Humanities and Social Sciences and the CLASS Lecture Hall according to Peter R assistant professor and organizer of the event Students in the spring semester will be presenting their knowledge of the languages in such genres as oratory historical narrations and cultural depictions Each language will also feature a taste of the countries that are represented as well as a fashion show with attire worn in the different regions where the languages are spoken People living on Guam who are conversant in any of the modern languages featured at the event are encouraged to attend and participate in the various activities planned for the day.  For additional information, Onedera may be reached at 735-2808 or by e-mail at ponedera53@yahoo.com Poll results are published every Monday in The Guam Daily Post Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: A moderate magnitude 4.5 earthquake occurred in the Philippine Sea 59 km SSE of Kushima The quake had a shallow depth of 35 km (22 mi) and was not felt (or at least not reported so) A strong magnitude 4.7 earthquake occurred in the Philippine Sea near the coast of Miyazaki,  Japan The quake had a very shallow depth of 26 km (16 mi) and was reported felt by some people near the epicenter.