then the cells can't repair themselves and die because of the radiation,” says Scott T speculates on the mechanism of action for 177Lu-TLX591 (177Lu-DOTA-rosopatamab) which is being assessed in the phase 3 ProstACT GLOBAL trial (NCT06520345) in patients with metastatic castration-resistant prostate cancer (mCRPC) Tagawa is a professor of medicine and urology at Weill Cornell Medicine and an attending physician at NewYork-Presbyterian – Weill Cornell Medical Center in New York We know that whether it's an antibody or small molecule I mentioned before the places that the antibody typically doesn't bind but it binds to PSMA and then is internalized That's one thing that is different in terms of antibody for small molecules Small molecules are internalized and externalized and whatever's attached to it is brought into the cell We think the mechanism of action is radiation leading to DNA damage then the cells can't repair themselves and die because of the radiation but I think the primary mechanism is radiation that is delivered to all of the PSMA-positive cells it's going to be most tumors in the advanced disease state will be PSMA-positive Those small fractions that are negative are not included in the study There is a screening PSMA-PET that is done that will eliminate those that have low or no PSMA expressions visible on the scans This transcript was AI generated and edited by human editors for clarity Phase 3 trial of capivasertib in mCRPC discontinued following IDMC recommendation Pearls & Perspectives: Helen Bernie, DO, MPH, at AUA 2025 ARANOTE substudy highlights benefits of darolutamide in Black men Dr. Murphy on increasing diversity in cancer clinical trials TikTok, social media does more harm than good for prostate cancer education FDA clears AI-powered application for measuring prostate volume 609-716-7777 The BESS project has a capacity of 30MW/130MWh which is operated by Honeycomb 8 LLC and an adjacent 2MW solar project operated by Honeycomb 12 LLC Construction has started in 2024 and completion is targeted for February 2026 The BESS project in Tagawa City was one of the 11 BESS projects awarded to the HES under the FY2023 long-term decarbonisation auction (LTDA) hosted by the Organization for Cross-regional Coordination of Transmission Operators (OCCTO) and the Ministry of Economy It was the biggest winner with a combined capacity of 342MW of BESS projects spread across six regions in Japan HES is a wholly owned subsidiary of Hexa Renewables which is a portfolio company of I Squared Capital All websites use cookies to improve your online experience They were placed on your computer when you launched this website You can change your cookie settings through your browser The delightful video game scumbags you absolutely loved to hate What would most video games be without a villain ultimate obstacle during the player's epic journey a great antagonist can bring so much flavour and personality to a game perhaps even proving more memorable and entertaining than the hero themselves And while gaming is becoming an increasingly rich medium for villains written with real nuance there's also something to be said for more out-there antagonists who just really really love being evil and will let you know all about it We're talking of course about the card-carrying heels of gaming history - the villains who took relish in sadistically putting us through the wringer and clearly just cherished being as despicable as possible they were all charming to the extent that players probably smiled every time they showed up their presence ensuring that something cool or hella fun was about to happen these games wouldn't have been nearly as enjoyable.. Heels don't get much more emphatic than Tekken's Heihachi Mishima - after all this is the guy who threw his own unconscious son his all-consuming desire for world domination and immortality speaks for itself and pretty much everything he does is part of a Machiavellian scheme to exercise control over others But it's also tough to deny that Heihachi is really damn cool from his ridiculous finger-in-a-plug-socket hairstyle to his piercing gaze and general status as the world's swolest grandpa Heihachi holds no quarter even for the demonically infused members of his own family and will barrel through anyone who gets in his way.  even death can't stop the guy - he's apparently perished numerous times throughout the series most recently being lobbed into a volcano himself by his son Heihachi is royalty as video game villains go because so few others manage such an effortless fusion of cool and sheer commitment to being a huge a**hole WhatCulture is part of Future plc, an international media group and leading digital publisher. Visit our corporate site (opens in new tab) ©Future Publishing Limited Quay House England and Wales company registration number 2008885 ProstACT GLOBAL is assessing the safety and efficacy of 177Lu-TLX591 plus SOC vs SOC alone in patients with mCRPC highlights the phase 3 ProstACT GLOBAL trial (NCT06520345) which is assessing the safety and efficacy of 177Lu-TLX591 plus standard of care (SOC) vs SOC alone in patients with metastatic castration-resistant prostate cancer Tagawa isa professor of medicine and urology at Weill Cornell Medicine and an attending physician at NewYork-Presbyterian – Weill Cornell Medical Center in New York ProstACT GLOBAL is a study investigating a PSMA-targeted radionuclide with lutetium 177 the way that we first started targeting PSMA was with antibodies and this study uses the first antibody that was able to target viable cells but that binds to the internal domain of PSMA so therefore can only bind to necrotic cells vs other antibodies upon binding it gets internalized and retained That has been really labeled with lutetium 177 which is a beta emitter and completed a number of early phase clinical trials Patients with pre-treated metastatic CRPC receiving that and showed some efficacy at the expense of toxicity with myelosuppression the antibodies tradeoff vs small molecules is it's too big to get into areas such as the salivary glands or kidneys or intestines so we don't see as much dry mouth or nausea but what we do see is the potential for myeloppression In the quote pivotal study—it was only 17 patients—at the maximum tolerated dose it showed an overall survival of 40 plus months but that seems to be less in this particular target population for ProstACT AUA 2025 recap: Urologic oncology trials in progress Pearls & Perspectives: Expanding BPH care & patient choice, with Kevin Zorn, MD, at AUA 25 TAR-200 elicits high complete response rate in BCG-unresponsive NMIBC Pearls & Perspectives: Future of reconstructive urology, with Ryan Terlecki, MD, at AUA 2025 TAR-200 boasts impressive DFS rates in papillary disease-only NMIBC Ultra-low PSA responses are more prevalent with darolutamide plus ADT Kyosuke Tagawa has left Hearts to join Kashima Antlers The forward makes a permanent move to the J-League side for an undisclosed fee subject to international clearance and Scottish FA approval 25-year-old Kyosuke arrived at Hearts last summer and would go on to make 20 appearances including a memorable last-minute rasping volley against Rangers in the final game of last season Head Coach Steven Naismith said: “Kyosuke has been great to work with He is a good person and a good professional and he’s built up a relationship with his teammates he hasn’t managed to get the amount of minutes on the pitch that he would’ve liked and you can probably put that down to the form of our other forwards over the past year “He wants to play regularly so when the opportunity arose for him to return to the J-League “I thank Kyosuke for his efforts at Hearts and wish him all the best for the future.” © Copyright 2016 - 2025 Heart of Midlothian Mike Tagawa sits in front of shelves jammed with books record albums and memorabilia from his activist life Dangling in front of the shelves are stringed instruments Mike Tagawa might say his biggest claim to fame was that Jimi Hendrix left Seattle still owing him a quarter They were classmates at Garfield High School and Washington Junior High — back when he knew Hendrix as James — and they’d sneak out of class for smokes 25 cents passed between the two impoverished boys one who couldn’t afford to lose the sum and the other who couldn’t afford to pay it back but only part of a richer cache that makes Tagawa a living intersection of formative civil-rights history in Seattle and the city’s most interesting and unheralded 75-year-old leftist activist you’ve probably never heard of Roosevelt in 1942 signed Executive Order 9066 clearing the way for the forced removal of 120,000 people of Japanese descent from the West Coast Among them were Tagawa’s parents and three older siblings; they were incarcerated at Minidoka a Japanese concentration camp in southeast Idaho His birthday also is marked annually by Japanese American communities across the country as the Day of Remembrance the first of which occurred in Seattle in 1978 Both fall within what now is celebrated as Black History Month He was one of a handful of Japanese Americans who belonged to the Black Panther Party serving as the Seattle chapter’s minister of education and no internet connection. Yet he remains plugged in and has much to say A lot of that is delivered with a kind of look that suggests he knows more than he is letting on He wears such an expression as he addresses the fact that his old neighborhood commonly is referred to as the CD “When anyone asks what CD stands for,” he says where his home is a monument to all the fortuitous zigs he took where most others might have zagged from the revolutionary thoughts of Che Guevara to a coffee-table volume of lynchings that he shows visitors as proof of our country’s abhorrent capabilities Amid the activist memorabilia are mementos from what seems like another life He volunteered for military service for the country that dragged his family to Minidoka Tagawa later spent 36 years driving buses for Metro And he gets calls from people looking for the longest tenured off-site repairman for the guitar company C.F “I searched for you and found a Mike Tagawa who was a member of the Black Panther Party,” they’ll say They might be shocked to know that this white-haired man with a gentle soul once stormed Rainier Beach High School with other Black Panthers over rumors that Black students were being bullied by whites Tagawa recalls standing with Seattle police outside the school a .357 Colt revolver slung over his shoulder They were times when Tagawa and the Black Panthers believed they were part of a worldwide movement and the only impediments to what seemed like inevitable change were right in front of them — local government and police The Panthers believed they were on equal footing with Today’s police are armed-to-the-teeth militia and American society is too splintered to offer much resistance to misguided authority Tagawa remains loyal to his roots with Seattle’s Freedom Socialist Party and its radical feminism he finds so attractive and much in the world that he held so dear has been gutted or destroyed: Seattle’s Japanese American community gentrification and plunging civility have materialized in their stead Tagawa blames his emerging pessimism on two-plus years of beatdowns by Donald Trump He says the president’s biggest impact has been revealing the vast limits to which people can be pushed without pushing back “There is a lot more diversionary bullshit in our lives,” Tagawa says all of our energy is being dissipated in so many different ways I don’t see how people can unite behind any kind of action Our disenfranchisement and alienation just keep increasing and the pressure on people just to survive also keeps on increasing.” He says his 75 years have yielded “balance,” and even the bad has helped him grow he decided to memorialize some of the not-so-good having “11820-F” tattooed in a conspicuous place Many have guessed incorrectly as to its meaning; one young woman surmised the tattoo was his girlfriend’s phone number The numbers were assigned to his family at Minidoka the F signifying his place in the Tagawa pecking order Tagawa decided to place the tattoo on his right hand where he would have to look at it the rest of a life lived so unexpectedly yet true We rely on donations from readers like you to sustain Cascade PBS's in-depth reporting on issues crticial to the PNW Rachel Belle visits the vibrant Vietnamese shop Hello Em and tries an Ethiopian coffee ceremony at Lands of Origin The Lucky Chow host says soy sauce makes everything taste better Enjoy a few extra bites with your favorite guests as host Rachel Belle shares fresh audio from the cutting-room floor Glenn Nelson is a Japanese American columnist covering race and equity in the Pacific Northwest As Republican legislators opt for ballot harvesting Democrats lean into town halls in predominantly red districts to engage new or reluctant voters spoke about the implications of the results from his research on treatment patterns of patients with metastatic castration-sensitive prostate cancer as well as the need for further studies with other data sets CancerNetwork® spoke with Scott T. Tagawa, MD, MS, a professor of medicine at Weill Cornell Medicine and physician at NewYork-Presbyterian – Weill Cornell Medical Center, at the 2021 European Society for Medical Oncology (ESMO) Congress about his research into treatment patterns and overall survival in patients with metastatic castration-sensitive prostate cancer from 2006 to 2019 although only 20% of patients with metastatic castration-sensitive prostate cancer in this research received intensified therapy there was a general improvement to length of life which he described as the most appropriate therapy for the average patient with this disease should be given to more than just a minority of patients This and other population-based or claim-based big databases look at hundreds or thousands of patients up through 2019 [and those receiving intensified therapy are] still in the minority of patients but a huge chunk of patients are receiving either [androgen deprivation therapy; ADT] alone or ADT plus an old-fashioned nonsteroidal antiandrogen as their frontline therapy This is despite approximately a 40% improvement in overall survival with those novel drugs being used earlier rather than saved for later not just in this Veterans Health Administration but in other data sets [including] Medicare and some different commercial insurance plans I think we need more research into why that’s happening and more education or a combination of both Providers as well as patients [need assistance] to figure out why patients are not getting the optimal therapy Treatment patterns and overall survival (OS) in metastatic castration-sensitive prostate cancer (mCSPC) from 2006 to 2019 Stay up to date on recent advances in the multidisciplinary approach to cancer 74 Lessons Learned From a Breast Surgery ERAS Program in an Oncologic Ambulatory Center Prolaris in Practice: Guiding ADT Benefits, Clinical Application, and Expert Insights From ACRO 2025 FACRO discuses how Prolaris distinguishes itself from other genomic biomarker platforms by providing uniquely actionable clinical information that quantifies the absolute benefit of androgen deprivation therapy when added to radiation therapy offering clinicians a more precise tool for personalizing prostate cancer treatment strategies 76 Electromagnetic Chip Bracketed vs Wire Bracketed Localization in Breast Conserving Surgery CCR Scores and Beyond: Precision Strategies for Treatment Intensification in Prostate Cancer MD discusses how emerging genomic risk stratification tools such as the clinical cell-cycle risk (CCR) score are transforming personalized prostate cancer treatment by enabling more nuanced assessments of metastasis risk and treatment intensification strategies beyond traditional NCCN risk groupings Avutometinib Combo Shows Activity, Safety for HR+/HER2- Breast Cancer Preliminary results from a phase 1 trial show an objective response rate of 13.3% with avutometinib and fulvestrant in CDK4/6 inhibitor–resistant HR+/HER2– metastatic breast cancer EVP Before Consolidative Surgery Optimizes Responses in Urothelial Cancer No 90-day mortality was observed among patients who were treated with EVP followed by surgery for advanced urothelial cancer Metrics details Hydrogen is one of the possible alloying elements in the Earth’s core but its siderophile (iron-loving) nature is debated Here we experimentally examined the partitioning of hydrogen between molten iron and silicate melt at 30–60 gigapascals and 3100–4600 kelvin We find that hydrogen has a metal/silicate partition coefficient DH ≥ 29 and is therefore strongly siderophile at conditions of core formation Unless water was delivered only in the final stage of accretion core formation scenarios suggest that 0.3–0.6 wt% H was incorporated into the core leaving a relatively small residual H2O concentration in silicates This amount of H explains 30–60% of the density deficit and sound velocity excess of the outer core relative to pure iron Our results also suggest that hydrogen may be an important constituent in the metallic cores of any terrestrial planet or moon having a mass in excess of ~10% of the Earth we report experiments to constrain the partitioning of hydrogen between molten iron and silicate melt at high P–T to 60 GPa The results demonstrate the strongly siderophile nature of hydrogen under conditions where metals segregated from silicates during Earth’s core formation suggesting that hydrogen is an important light element in the core hydrogen may be a major impurity element in the metallic cores of other terrestrial planets and moons whose masses are more than 10% of that of the Earth The numbers given to each datum point and regression line indicate pressure conditions The metal–silicate partitioning of hydrogen can be expressed as a chemical reaction The exchange coefficient KD is parameterized as a function of P (GPa) and T(K) with regression constants a, b, and c (Fig. 2b) Least-squares fitting to our data yields a = 2.42 (18) The corresponding ocean mass of water (OC) that includes an equivalent amount of hydrogen is also indicated (right vertical axis) Considering three different water delivery scenarios we find that 0.3–0.6 wt% H in the core is necessary to leave a residual budget of ~690 ppm H2O in the BSE unless water was delivered only in the last stage of Earth accretion The present Earth values are shown by gray bands Water content in the glass was confirmed using SIMS analyses (see below) Experiments were performed in a laser-heated DAC with flat 300 μm culet diamond anvils Iron foil (5–7 μm thick) was sandwiched between the hydrous MORB glass powder and loaded into a ~140 µm hole at the center of a pre-indented rhenium gasket except for run #1 in which ~0.6 wt% H2O was added by mixing glass containing 0.2 and 1.0 wt% H2O the entire DAC was dried in a vacuum oven at 400 K for 3–8 h As soon as the DAC was taken out of the oven XRD patterns were collected before/during/after heating in each run. A monochromatic X-ray beam with an energy of ~30 keV was focused to 6 μm area (full-width at half-maximum) on a sample position. The XRD data were collected every 0.22 s during heating on a flat panel detector (Perkin Elmer) (Fig. 1a) The X value was found to be homogeneous in the metal the proportions of FeHX and FeOOH are estimated from the Fe and O contents in quenched liquid iron that were obtained by electron probe micro-analyzer (EPMA) analyses (see below) we can quantify the abundance of each element from the intensity map and 40Ca+ with 0.5–1.2 µm spatial resolution for 1H+ were collected using the 16O− primary beam (13 keV 37 nA) that was focused to 20–30 μm in diameter and rastered across a 100 μm × 100 μm region on the sample surface We set the contrast aperture to be 100 μm in diameter with the exit slit fully opened In order to minimize the effect of adsorbed water on the sample surface we employed the energy slit to be ±20 eV to select kinetic energy ranges of secondary ions from 80 to 120 eV by loading a sample offset voltage of −100 V The pressure during measurements was 6.5–8.0 × 10−8 Pa and 40Ca were obtained sequentially in the following order; 28Si+ Accumulation time was 500 and 100 s in each image and two and three images were combined to calculate concentration maps for 1H+ and 28Si+ The hydrogen content X in FeHX ranged from 0.23 to 1.78 in the present study (Supplementary Table 1) Large X significantly decreases the molar fractions of Fe and O in metal it apparently increases the oxygen fugacity \(\Delta {\mathrm{IW}} \approx 2\log _{10}\left( {x_{{\mathrm{FeO}}}^{{\mathrm{silicate}}}{\mathrm{/}}x_{{\mathrm{Fe}}}^{{\mathrm{metal}}}} \right)\) and decreases the exchange coefficient \(K_{\mathrm{D}}^{\mathrm{O}} = \frac{{x_{{\mathrm{Fe}}}^{{\mathrm{metal}}}x_{\mathrm{O}}^{{\mathrm{metal}}}}}{{x_{{\mathrm{FeO}}}^{{\mathrm{silicate}}}}}\) for the reaction FeOsilicate = Femetal + Ometal we approximate the activity of element i in metal as: which supports the validity of the present estimate of the activities of elements in metal and silicate Our experiments give log10\(K_{\mathrm{D}}^{\mathrm{O}}\) = a + b/T no hydrogen is partitioned into metal when PMOB,i < 3 GPa leading to the minimal incorporation of hydrogen into the core we apply DH > 34 above 3 GPa when following the same P–T evolution for metal–silicate equilibration in this study The equilibrium efficiency between impactor metal and the proto-Earth’s silicate is controlled by Γ at each step which is the ratio of the mass of equilibrated silicate over the mass of each impactor core We performed 1000-step calculations of metal–silicate partitioning and rimp core is the radius of impactor’s core Both the mass of impactor silicate and core, mimp silicate and mimp core, are obtained when ΦFe, ΦSi (the proportions of metallic Fe and Si with respect to all Fe and Si) and H2O concentration of the impactor are given. rimp is found, for example, to be 408 km when ΦFe = 0.99, ΦSi = 0.17, H2O=1.1 wt% and N = 1 (Supplementary Table 3) It could be argued that the average impactor size during Earth accretion was smaller (N > 1) considering the biggest asteroid Ceres is 473 km in radius in an embryo with 1/10 Earth’s mass and a radius of ~3200 km the depths of the core–mantle boundary and the bottom of the MO (Z100) are ~1500 and ~900 km We have calculated the partitioning of H, Ni, Co, O, and Si between the impactor metal and equilibrated silicate (whose mass is obtained by Γi) under PMOB,i = Pfinal × (i/1000)2/3 and three different T at each step (Supplementary Fig. 1): TMOB1,i = (same as that for the continuous core formation model above) \(T_{{\mathrm{MOB3}},i}= \left\{\begin{array}{*{20}{l}}1874 + 55.43P_{{\mathrm{MOB}},i}- 1.74P_{{\mathrm{MOB}},i}^{2} + 0.0193P_{{\mathrm{MOB}},i}^{3 } (< 24 {\mathrm{GPa}}) \\ 1249 + 58.28P_{{\mathrm{MOB}},i}- 0.395P_{{\mathrm{MOB}},i}^{2} + 0.0011P_{{\mathrm{MOB}},i}^{3 } (\ge \,24 \,{\mathrm{GPa}})\end{array}\right.\) They are compared with those obtained only from our data in Supplementary Fig. 11 consistent with those obtained by other simulations The data supporting the main findings of this study are available in the paper and it’s Supplementary Information Any additional data can be available from the corresponding authors upon reasonable request Convergence of Ni and Co metal–silicate partition coefficients in the deep magma-ocean and coupled silicon–oxygen solubility in iron melts at high pressures Metal–silicate partitioning of Ni and Co in a deep magma ocean High pressure metal–silicate partitioning of Ni Core formation and the oxidation state of the Earth Core formation and core composition from coupled geochemical and geophysical constraints Accretion and differentiation of the terrestrial planets with implications for the compositions of early-formed Solar System bodies and accretion of water Experimental constraints on core composition Hydrogen partitioning into molten iron at high pressure: implications for Earth’s core Hydrogen partitioning between iron and ringwoodite: implications for water transport into the Martian core Hydrogenation of iron in the early stage of Earth’s evolution Low hydrogen contents in the cores of terrestrial planets Experimental constraints on the fate of H and C during planetary core-mantle differentiation Carbon and other light element contents in the Earth’s core based on first-principles molecular dynamics Strong sequestration of hydrogen into the Earth’s core during planetary differentiation Iron–water reaction under high pressure and its implication in the evolution of the Earth Constraints on the early delivery and fractionation of Earth’s major volatiles from C/H The hydrogen isotope composition of seawater and the global water cycle Isotope composition and volume of Earth’s early oceans Strange messenger: a new history of hydrogen on Earth Se and Te in the silicate Earth require a volatile-rich late veneer Liquid iron‐hydrogen alloys at outer core conditions by first‐principles calculations Chemical compositions of the outer core examined by first principles calculations Origin of Earth’s water: chondritic inheritance plus nebular ingassing and storage of hydrogen in the core Evidence for primordial water in Earth’s deep mantle Anomalous 182W in high 3He/4He ocean island basalts: fingerprints of Earth’s core A low mass for Mars from Jupiter’s early gas-driven migration On the water delivery to terrestrial embryos by ice pebble accretion High-resolution simulations of the final assembly of Earth-like planets The fate of subducted basaltic crust in the Earth’s lower mantle Melting phase relations and element partitioning in MORB to lowermost mantle conditions Outer core compositional layering and constraints on core liquid transport properties and freezing of Mg2SiO4 liquid at high pressure Melting experiments on Fe–Fe3S system to 254 GPa High-pressure Raman spectroscopy of diamond anvils to 250 GPa: method for pressure determination in the multimegabar pressure range Solidus and liquidus profiles of chondritic mantle: implication for melting of the Earth across its history Some properties of the Fe-H system at high pressures and temperatures and their implications for the Earth’s core In High-Pressure Research: Applications to Earth and Planetary Sciences Vol The influence of hydrogen on the seismic properties of solid iron Site occupancy of interstitial deuterium atoms in face-centred cubic iron Interstitial hydrogen atoms in face-centered cubic iron in the Earth’s core Quasihydrostatic equation of state of iron above 2 Mbar Equation of state of γ-Fe: reference density for planetary cores Elasticity of ε-FeOOH: seismic implications for Earth’s lower mantle High precision isotope micro-imaging of materials Hydrogen isotope ratios in lunar rocks indicate delivery of cometary water to the Moon Remnants of the early solar system water enriched in heavy oxygen isotopes Analysis of the noise properties of a solid-state SCAPS ion imager and development of software noise reduction Diffusive fractionation of H2O and CO2 during magma degassing Effect of water on metal–silicate partitioning of siderophile elements: a high pressure and temperature terrestrial magma ocean and core formation Effect of H2O on metal–silicate partitioning of Ni Mn and Fe: implications for the oxidation state of the Earth and Mars Melting of a dry peridotite KLB-1 up to 14 GPa: implications on the origin of peridotitic upper mantle A seismologically consistent compositional model of Earth’s core Crystallization of silicon dioxide and compositional evolution of the Earth’s core Terrestrial accretion under oxidizing conditions The isotopic nature of the Earth’s accreting material through time composition and core-mantle differentiation of the Earth Experiments on turbulent metal–silicate mixing in a magma ocean Geodynamics 3rd edn (Cambridge University Press Evidence for high-pressure core-mantle differentiation from the metal–silicate partitioning of lithophile and weakly-siderophile elements Water in the Earth’s interior: distribution and origin Cosmochemical estimates of mantle composition Download references Kawaguchi for their assistance in experiments at BL10XU Yoshimura is acknowledged for preparing standards for SIMS analyses Bouhifd and two anonymous referees were helpful to improve the manuscript This work was supported by JSPS Kakenhi to K.H and by the “Imaging Platform” program by MEXT Japan Synchrotron Radiation Research Institute designed and led the project together with K.H High-pressure experiments and SIMS analyses were performed by Y.O The authors declare no competing interests Peer review information Nature Communications thanks Jie Li and the other anonymous reviewers for their contribution to the peer review of this work Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41467-021-22035-0 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Progress in Earth and Planetary Science (2024) Communications Earth & Environment (2024) Sign up for the Nature Briefing newsletter — what matters in science This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page “It’s an exciting world in which we have all of these complications about what to do because it means we have a lot more choices for our patients,” said Scott Tagawa discusses the current state of immunotherapy use in the first-line setting for patients with advanced urothelial carcinoma Tagawa co-chaired a session at the Bladder Cancer Advocacy Network (BCAN) 2023 Think Tank titled “Defining treatment lines in metastatic urothelial cancer: Choosing the right targets and combinations.” there’s really only one truly “prime-time” [level-1-evidence–supported] immunotherapy in the first-line setting and that is in a patient who has had first-line platinum-based chemotherapy and has had disease control meaning a partial response or stable disease—we give those patients immunotherapy in the form of first-line avelumab maintenance The major part of patient selection [for upfront avelumab maintenance] is that they have not had primary progression on platinum-based chemotherapy And that would be kind of first-line switch maintenance therapy The other part of patient selection would be is the patient a candidate for anti–PD-L1 immunotherapy; and that is generally a question of [whether or not they have very active autoimmune disease] And then we’re about 3 months since the accelerated approval of enfortumab vedotin plus pembrolizumab in patients who are cisplatin unfit In the recent ASCO recommendations about what to do in the setting of the cisplatin and carboplatin shortage the nice thing is that enfortumab vedotin plus pembrolizumab was approved in this setting at the same time as the emergence of the severe carboplatin shortage I think no one has a problem [using this regimen] provided that the patient is a candidate and doesn’t have The harder part is with cisplatin because we know that there’s a subset of patients—and it’s mostly those with soft tissue metastasis—that gets cisplatin-based combinations and are cured But there’s a gray area about how much are we looking for cisplatin ineligibility we may be offering enfortumab vedotin plus pembrolizumab while we’re still waiting for the head-to-head data of enfortumab vedotin/pembrolizumab vs platinum/gemcitabine from the phase 3 EV-302 study (NCT04223856) but it’s an exciting world in which we have all of these complications about what to do because it means we have a lot more choices for our patients You release more toxins from the body through a deep exhale than you do from anything else so it was the closest to my own personality My look is Poly'n'Asian – part Polynesian native, part Asian warrior. I get more strange looks than compliments, but that's only natural. This shirt is by a company called Yellowman – the design is based on tattoos by famous Japanese tattoo artists I always liked the idea of taking a tattoo on and off Nature is a big part of my weekend. Whenever possible, I take Friday and Monday off and spend four days outdoors. We should remind ourselves that there was something here before us, a force more powerful than us. Then I have a Thai massage – I recommend the Formosa Centre in Marylebone Are you a Weekender? Email a photo and a brief description of how you spend your weekends to weekender@guardian.co.uk ShareSaveLifestyleTravelNagasaki Bomb Horrors 73 Years Later - As Told By Survivor Hiroyasu Tagawa (Part 2)ByJim Clash Forbes contributors publish independent expert analyses and insights Jim Clash writes about extreme adventure and classic rock.Follow AuthorAug 15 08:03am EDTShareSaveThis article is more than 6 years old.In the first part of this story about Japanese atomic bomb survivor Hiroyasu Tagawa he discussed the Nagasaki bombing itself and its immediate aftermath Tagawa tells about how he found his parents after the blast and watched them pass away in front of him Hiroyasu Tagawa (center) with Jim Clash (left) and Japanese translator (right) at the Nagasaki.. The unfortunate reality was slowly and excruciatingly hitting me I kept walking desperately as I wanted to find my father and mother as soon as possible to help them The Mitsubishi Steel Factory at the intersection to my left had been completely destroyed but I found a basket filled with cooked potatoes Since I had been walking around endlessly with a rumbling stomach I later realized that no one had probably cooked the potatoes they had been cooked by the heat of the bomb Eating them and drinking some well water from nearby I continued to walk around to look for my parents a woman with frizzy hair was sitting there So I squinted and then realized it was my mother I ran to the back of the shelter and there he was he was right next to some dangerous chemicals used at the factory so I went to a temporary aid station next to the bridge I’d walked by earlier I tried to escape with my parents to the neighboring town About half a day after arriving at Togitsu I heard that the Nagasaki Medical College Hospital had opened a temporary first aid station at Nameshi I immediately carried my father there with the help of some neighbors many women and children were walking listlessly ‘Where are you going kid?’ ‘I’m going to have my father’s injury treated We are trying to escape before the Americans come to attack us so I must go to the hospital.’ And so I headed to the temporary first aid station Near the hypocenter of the 1945 Nagasaki atomic bomb explosion is Nagasaki Peace Park The temporary first aid station in Nameshi had been set up to treat injured Nagasaki medical students amputation!’ And my father received the necessary medical attention immediately I sat there looking after him for the entire time My father until then had just been groaning ‘It hurts.’ It was the first time he had expressed his raw emotions the doctors had used a carpenter’s saw to cut off my father’s feet The aid station was filled with injured students I was planning to take my father home the next day I was able to find some space between two injured students who were laid out on the floor and by the time I woke up the next morning the students on both sides of me had already passed away I was devastated and in shock for two days Relatives whispered when they saw me not shedding any tears even though my father had died as some kind of demon I could not afford to show any sadness or pain so I survived by clinging to that sense of purpose I returned to Narutaki to tell of my father’s death 22 that my uncle from Togitsu came in a hurry by bicycle I borrowed my uncle’s bicycle and pedaled as hard as I could to Togitsu So she gave it her best to live one more day.’ My mother looked at me and whispered I could not stop the flooding tears anymore These were the first I had shed since the atomic bombing He would not allow me to eat dinner if my grades went down so I never received any words of encouragement from him But my neighbors told me he was actually so proud of me that he would brag about me to them Tagawa takes us through his reasons for coming forward to finally discuss his Nagasaki bomb experiences after of decades of repression and why the world must never use nuclear weapons again Interview Part 3: Nagasaki Survivor Recalls Horrors Of 1945 WWII A-Bomb Attack (Part 3) spoke about potential approvals in the coming year for prostate cancer At the15th Annual Interdisciplinary Prostate Cancer Congress® and Other Genitourinary Malignancies about current initiatives in prostate cancer He mentioned nearing approval of Lutetium-177 (177Lu-PSMA-617) and how it would help to expand upon treatment options for patients with prostate cancer Translation from research to therapeutics is going to have a significant impact on the lives of patients with advanced prostate cancer This happens to be PSA [prostate specific antigen],–targeted radionucleotides with the expected 2022 approval of 177Lu-PSMA-617 That’s going to be a near-term approval with a new class of drugs Hopefully we can expand upon that to make [treatment] even better by using it for earlier patient populations in combinations or in better patient selections It does not appear [to be ready for the real-world setting] at least not [with PD-1 or PD-L1 inhibitors] There are a number of other immunotherapeutics targeted typically against cell surface proteins such as PSMA [prostate-specific membrane antigen] or PSCA [prostate stem cell antigen] and a number of other cell service targets [that can be targeted with] either bispecifics I don’t think that’s ready for prime time today I’m quite hopeful that at least a substantial subset [of patients are] able to handle these drugs We might not just see an improvement for some number of months but some very durable responses or maybe even cures with some of these instruments Your browser does not support JavaScript, or it is disabled．Please check the site policy for more information YOKOHAMA--Nissan has outlined a “sustainability plan” to become a greener and more inclusive company won’t be trying to beat rivals in the effort but hopes to work with various partners told reporters this week at the company’s Yokohama headquarters Nissan is aiming to achieve carbon neutrality by 2050 which means net zero carbon emissions across all operations Nissan says that by 2030 it will reduce per-vehicle manufacturing CO2 emissions by 52% and cut per-vehicle driving CO2 emissions for new models by 50% in Japan Tagawa said the Nissan Social Program 2030 is centered around six pillars: safety The company is supporting education to nurture future engineers especially in relatively new areas like artificial intelligence and information technology “We aim to become a people-centric company,” he said reiterating the company’s commitment not to tolerate human rights violations in its operations and supply chain The latest plan is an update of Nissan’s Ambition 2030 which was centered around introducing more electric vehicles Tagawa acknowledged huge investments were needed which likely won’t pay off immediately but will translate into long-run returns He gave no specifics on the amount of investment planned says pay of managers will reflect their efforts in diversity and sustainability Sustainability is crucial in enhancing brand power Nissan also listed resource depletion and changing mobility needs as other concerns Awareness over climate change is growing in Japan record temperatures of above 40 degrees Celsius (104 Fahrenheit) were reached in parts of the country which dominated global markets in fuel-engines for decades are adjusting their strategies for what the industry sees as an inevitable transition to more ecological powertrains such as electric vehicles and fuel cells Experts say the world must reduce CO2 emissions to avert extreme weather conditions and serious damage to human health ecosystems and social infrastructure from climate change Reaching net-zero emissions by 2050 will require drastic emissions reductions Nissan lowered its full-year profit forecast to 300 billion yen ($1.9 billion) from an earlier projection of 380 billion yen ($2.5 billion) as its first quarter profits suffered despite steady sales because of incentives and marketing expenses It expects to sell 3.65 million vehicles globally in the fiscal year ending in March 2025 up from about 3.4 million vehicles worldwide for the last fiscal year Nissan promises aggressive electrification push to cut costs Nissan eager to leverage US tax credit on electric vehicles Nissan get Greenpeace thumbs-down for decarbonization efforts Nissan get Greenpeace thumbs-down for decarbonisation efforts Mitsubishi to unveil 2030 EV plans this week Information on the latest cherry blossom conditions Please right click to use your browser’s translation function.) A series based on diplomatic documents declassified by Japan’s Foreign Ministry Here is a collection of first-hand accounts by “hibakusha” atomic bomb survivors chefs and others involved in the field of food introduce their special recipes intertwined with their paths in life A series about Japanese-Americans and their memories of World War II In-house News and Messages No reproduction or republication without written permission If you’re on Twitter than you’re probably no stranger to seeing people tweet at an actor they admire Maybe you’ve done it yourself once or twice even it’s not every day that they tweet back or carry an ongoing conversation with you over the course of a about a week it had never happened to me until I tweeted at Cary-Hiroyuki Tagawa (@CHTofficial) Getting his start as an extra in Big Trouble in Little China Tagawa went on to play in several roles from The Last Emperor to Memoirs of a Geisha He even had a minor role in Star Trek: The Next Generation’s pilot think Tagawa has a great on-screen presence as villains in action movies and no action movie demonstrates that better than Showdown in Little Tokyo where he plays the Yakuza boss Mortal Kombat fans may disagree; Tagawa is Shang Tsung) Showdown in Little Tokyo is one of those action flicks often lambasted by critics for being an overly macho hamfest devoid of plot… Starring Dolph Lundgren as the ever musclebound cop with an affinity for Japanese culture and Brandon Lee in an early martial arts role Showdown in Little Tokyo’s fire-all-your-bullets-than-draw-your-katana-ballsiness is made complete by an entertaining performance from its bad guy action movies need three things to be good 1) A convincing violent bad guy with the moral compass of a cobra 2) A “good” guy with a convincing reason to fight back Needless to say I was happily surprised when Yoshida (Tagawa) himself responded to one of my tweets and took some time to discuss what it was being like on set with Lundgren and Lee What follows was a very informal conversation we had over Twitter. All of this was public (not held in DM) so I feel comfortable sharing it here. None of the answers have been doctored, but I did change the order in which they appear in my Twitter feed a little so you can better grasp our correspondence. Tagawa a little more about his experience stepping into the shoes of such an insane villain like Yoshida but at this time I have not heard back from him yet My guess is that he is busy working on another movie and that is completely fine I am very grateful for the answers he gave and his time… Who ever thought Shang Tsung would be such a nice guy over social media Follow me @ActionRation on Gab/Minds/Twitter Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Digital home ownership experience for a large bank in Canada Bespoke Loan Origination System for a Bank in Indonesia Tech Mahindra Unveils ‘AI Delivered Right’: A Comprehensive Strategy to Help Enterprises Scale AI with Purpose and Precision Join Tech Mahindra at IBM Think Boston 2025 Performance Assurance for Tier-1 Telematics Customer in North America a leading provider of digital transformation and business re-engineering services and solutions have signed a Memorandum of Understanding (MoU) to accelerate digital transformation in Tagawa City Tech Mahindra will leverage its expertise in next-generation technologies such as 5G Augmented Reality (AR) & Virtual Reality (VR) To further support the digital transformation journey Tech Mahindra and Tagawa City will work together to upskill the local talent with software engineering skills in Japan Tech Mahindra and Tagawa City will collaborate on the expansion of local 5G with Multi Edge Computing (MEC) as well as the development of new hardware and software using AR and VR Tech Mahindra will help Tagawa City in its vision for the digitalization of sports facilities using technologies such as motion cameras and Artificial Intelligence (AI) to enhance accessibility and provide better experiences for all said“We thank Tech Mahindra for their cooperation in this public-private partnership with Tagawa City We will leverage their expertise in digital technologies to bring about positive change in our city this partnership will help us achieve our vision for a smart city and provide benefits to our residents and local businesses." will collaborate to digitally transform the tourism industry through the use of AR and other technologies such as body temperature and physical condition management of cows using AI cameras and the digitalization of the tourism industry Tagawa City will also benefit from the development of smart parks and camping grounds as well as new forms of entertainment such as forest cinemas said,,“Digital transformation has become one of the top priorities for organizations and governments today to keep pace with the ever-changing post-pandemic world Japan is one of the most advanced and innovative countries in the world and our collaboration with Tagawa City is a major step forward in strengthening our ties with the country we look forward to working closely with Tagawa City to develop new technologies and services that can enhance the quality of life of Tagawa City’s citizens we foresee significant growth across various industries This partnership is in line with Tech Mahindra’s NXT.NOW ™ framework which aims to enhance ‘Human Centric Experience’ and focuses on investing in emerging technologies and solutions that enable digital transformation and meet the evolving needs of the customer used to be the center of Japan’s coal mining industry and to this day Tagawa is known for its famous coal mining dance Due to the importance of its coal industry for the modernization of Japan between the middle of the 19th and the middle of the 20th century Tagawa was often called Japan’s “coal capital” The switch of Japan’s economy from coal to oil as its major source of energy in the 1960s brought an end to the coal industry in Tagawa which led to an era of decline The city is proud of its coal mining heritage but nowadays is also putting attention to its culture the city has been certified as a “leading inclusive host town” as a result of its many efforts in the field of inclusion like hosting camps for the Tokyo 2020 Olympic and Paralympic Games Tagawa’s goal is to become an inclusive city where everyone is welcome and can play an active role focus is put on educational reforms and the improvement of child care Tech Mahindra offers innovative and customer-centric digital experiences We are a USD 6 billion organization with 163,000+ professionals across 90 countries helping 1279 global customers We are focused on leveraging next-generation technologies including 5G to enable end-to-end digital transformation for global customers Tech Mahindra is the only Indian company in the world to receive the HRH The Prince of Wales’ Terra Carta Seal for its commitment to creating a sustainable future We are the fastest growing brand in ‘brand strength’ and amongst the top 7 IT brands globally Tech Mahindra aims to enhance ‘Human Centric Experience’ for our ecosystem and drive collaborative disruption with synergies arising from a robust portfolio of companies Tech Mahindra aims at delivering tomorrow’s experiences today and believes that the ‘Future is Now’ one of the largest and most admired multinational federation of companies with 260,000 employees in over 100 countries It enjoys a leadership position in farm equipment information technology and financial services in India and is the world’s largest tractor company by volume It has a strong presence in renewable energy The Mahindra Group has a clear focus on leading ESG globally enabling rural prosperity and enhancing urban living with a goal to drive positive change in the lives of communities and stakeholders to enable them to Rise Connect with us on  WWW.TECHMAHINDRA.COM   Our Social Media Channels Facebook Twitter LinkedIn YouTube  For more information on Tech Mahindra, please contact:        Abhilasha Gupta, Global Corporate Communications and Public Affairs     Email: ABHILASHA.GUPTA@TECHMAHINDRA.COM; MEDIA.RELATIONS@TECHMAHINDRA.COM News link > highly curated editorial content brings attention to hidden gems Share LinkHere Are The 7 Most Beautiful Gardens You’ll Ever See In ColoradoDiscover some of the best gardens to visit in Colorado during the spring and summer months There is no doubt that Colorado is a gorgeous state with so much to offer. Take a look at this video of more amazing places in Colorado you'll want to visit by @OnlyInYourState: Choose your stateAlabamaAlaskaArizonaArkansasNorthern CaliforniaSouthern CaliforniaColoradoConnecticutDelawareFloridaGeorgiaHawaiiIdahoIllinoisIndianaIowaKansasKentuckyLouisianaMaineMarylandMassachusettsMichiganMinnesotaMississippiMissouriMontanaNebraskaNevadaNew HampshireNew JerseyNew MexicoNew YorkNorth CarolinaNorth DakotaOhioOklahomaOregonPennsylvaniaRhode IslandSouth CarolinaSouth DakotaTennesseeTexasUtahVermontVirginiaWashingtonWest VirginiaWisconsinWyomingSubscribe... This Airbnb with a fishing pond in Louisiana is an angler's paradise. The two-acre, catch-and-release oasis is stocked with bass, bream, and catfish. Thanks for subscribing. We’ll see you in your inbox! Legit.ng Hausa ta bude tasha a manhajar Whatsapp. Kasance tare da mu don samun rahotanni da dumi-dumi! ya na da gogewar aikin jarida sama da shekaru biyar FCT, Abuja - A wata muhimmiyar ziyara ta diflomasiyya domin dawo da amana da hadin kai, Ministan Harkokin Wajen Najeriya, Yusuf Maitama Tuggar, zai kai ziyara Jamhuriyar Nijar. Yusuf M. Tuggar zai mika sako na musamman daga Bola Tinubu ga Janar Abdourahamane Tchiani a ranar Laraba, 16 ga Afrilu, 2025. Kara karanta wannan majalisa ta kafa kwamitin lura da ayyukansa Bola Tinubu zai tura tawaga ta musamman zuwa Nijar a gobe Laraba. Hoto: Asiwaju Bola Tinubu, Muhammad Badamasi.Asali: FacebookMusabbabin ziyarar tawagar Tinubu zuwa Nijar Ziyarar na nuna wani sabon salo a dangantakar Najeriya da Nijar, bayan rikicin juyin mulkin Yulin 2023 da ya dagula huldar kasashen biyu, cewar Zagazola Makama. LURA: Shin kana son bamu labari da tattaunawa da marubutanmu Tuggar zai tattauna da ministan harkokin wajen Nijar kan batutuwa masu muhimmanci irin su tsaro Ziyarar na zuwa ne a lokacin da yankin ke fuskantar sauye-sauye bayan ficewar Nijar Tattaunawar Najeriya da Nijar na nuni da yunkurin sabunta dangantaka da gina wata sabuwar fahimta bisa moriyar juna da mutunta juna Tawagar Najeriya za ta kunshi manyan jami’an diflomasiyya masu ba da shawara da jami’an tsaro domin tsara sabon tsari na hadin gwiwa Ana sa ran zai gana da Shugaba Abdourahamane Tchiani domin tattauna yadda za a daidaita alakar diflomasiyya ta doka da tsarin dindindin. A cewar wata majiya daga ma’aikatar harkokin wajen Najeriya, ziyarar na da nufin karfafa fahimta da gina dangantaka mai dorewa da Nijar. Kara karanta wannan Ziyarar na nuni da jajircewar Shugaba Tinubu wajen dawo da Nijar cikin tsarin zaman lafiya da hadin gwiwa a yammacin Afirka Bola Tinubu zai tura tawaga mai ƙarfi Nijar yayin da ta yi tsami Hoto: Federal Ministry of Foreign Affairs.Asali: TwitterAbubuwan ci gaba da ziyarar za ta samar Ma’aikatar harkokin wajen Najeriya na fatan irin wadannan dabaru za su taimaka wajen kwantar da tarzoma a Nijar ba tare da amfani da soja kawai ba Najeriya da Nijar na da mahimman hanyoyin ciniki, musamman daga jihohin Arewa zuwa yankunan Zinder da Maradi a Nijar. Rikicin tsaro da rufe iyakoki ya durkusar da harkokin kasuwanci, yana cutar da ‘yan kasuwa da dama masu dogaro da cinikayya tsakanin kasashen biyu. Ana fatan ziyarar za ta kai ga bude kasuwannin iyaka, hadin gwiwar sintirin tsaro da kuma sabunta manyan ayyukan ci gaba na iyaka. Ziyarar ta nuna yadda Najeriya ke kokarin kafa sabuwar alakar tsaro da tattalin arziki, tare da hada kai da Nijar a wajen ECOWAS. Tawagar ministan za ta mika shawarwari ga gwamnati Nijar kan tsaron iyaka, farfado da tattalin arziki da diflomasiyya ta al’umma. Kara karanta wannan an 'gano' shirinsa kan ƴan APC da ke son komawa SDP Mun ba ku labarin cewa gwamnatin sojan Nijar ta ayyana Hausa a matsayin harshen kasa tare da cire Faransanci wanda ya samo asali daga mulkin mallaka Rahotanni suka ce Hausa ta riga ta zama gama gari a Nijar yayin da kashi 13% kacal ke jin harshen Faransanci Actor Cary-Hiroyuki Tagawa plays Japanese immigrant Hashimoto who has lived most of his life in the U.S. but is still seen as an enemy and a threat to the country in the upcoming film from director Alejandro Monteverde I’ve been blessed to have a great career as an actor in Hollywood. You may have seen me in “Star Trek: The Next Generation,”  “The Last Emperor” and even the James Bond film “License To Kill.” So why would I bother to write an article like this for my latest film Because it’s a film that is special to me because it represents a turning point in my career my arriving at what I consider the halfway mark in my work in Hollywood and a chance to see where I’ve come from and where my work is going especially in the area of revealing more of who I am and the issues I’ve faced in my life and career In “Little Boy,” my character Hashimoto has lived most of his life in America but is still seen as an enemy and a threat to the country the story centers around how a small town in California deals with Hashimoto I was born about seven years after the time this film is set in and 10 years later I was enrolled in a military dependent school because my father was a lifer in the U.S Louisiana and Texas and in each of these locations we were often the only Asian family in the area There was very little reason for Asian families to be in such places unless they were military or stayed on after the period of internment While I wasn’t in America during the internment my life was still very much influenced by it with strong racism present almost everywhere I liken my experience to being a stranger in a strange land; going from a 5-year-old living in Tokyo to suddenly finding myself in North Carolina These travels have always been about dichotomy: being raised in two cultures — Japanese and American — that are considered to be polar opposites and the question for me was often: How was I to take both of these experiences and create some sort of framework to understand them Remembering my childhood has served as a reminder to me to take this emotional and psychological makeup from my own experiences and help me to better understand Hashimoto What is fascinating about this film is that it’s about America through the eyes of two Mexican-American immigrants — director Alejandro Monteverde and producer Eduardo Verastegui who have done an excellent job of putting together the romanticized with both Hashimoto and Jakob (Little Boy) coming of age together in the midst of difficulty Not only do I feel a personal connection to Hashimoto’s character but being a father I can see how he helps the little boy cope with his father’s capture during the war the son of a Japanese woman and a Japanese-American military man I began my career as an actor with the goal of changing America’s perception of the Japanese I wanted to fight against the various stereotypes of Japanese that I grew up seeing and hearing and I didn’t want my son to have to grow up burdened by them It was quite difficult to get away from these stereotypes as I began working in Hollywood back in 1986 and I had to take on many of these stereotypical roles to begin my career many others could have jumped into my place without the mindset of improving Japanese-American relations I can absolutely say I have done my best to do this Sometimes it just means being different and distinct The worst case scenario is when people hear of a movie you were in and don’t remember you even in the minor roles to keep your career going and “Little Boy” is a turning point in my career; the beginning of a second half of my work Director Monteverde and I worked hard together to make the character of Hashimoto authentic and touching we each bring very different perspectives to the film I did everything I could to make Hashimoto human and not a typical stereotype of good and Monteverde was always open to hearing my ideas At one point he even said I knew Hashimoto better than he did As with “Little Boy,” I have never been afraid to speak out for my creativity which has allowed my roles to be much more fulfilling than those of actors who don’t speak up and are just there to do a job It has always been an opportunity to further my people I hope that my work allows Americans and people around the world to look beyond the stereotypes that we’ve all learned along the way and to instead understand our shared humanity If “Little Boy” accomplishes that then I will look on with great satisfaction at the work I’ve accomplished and the work that lies ahead “Little Boy” co-stars Emily Watson, Michael Rapaport, David Henrie and Eduardo Verástegui Sign up for our daily Newsletter and stay up to date with all the latest news You are receiving this pop-up because this is the first time you are visiting our site You are using software which is blocking our advertisements (adblocker) we are relying on revenues from our banners So please disable your adblocker and reload the page to continue using this site.Thanks Tagawa Greenhouse is using soft-filled Ellepots produced in a FlexAIR machine to root vegetative cuttings quicker with more roots and improved labor efficiency has been growing a variety of seed and vegetative crops since it began operating in 1967 The company evolved from initially growing vegetable transplants for local farmers to propagating vegetative cuttings and seedling plugs that are distributed through Ball Seed Co The company purchased two 10-acre greenhouse facilities in Golden in 1997 that now propagate about 25 million vegetative cuttings annually In addition to rooting young starter plants the company also has prefinished and finished pot plant programs that include bedding plant mixed containers The finished pot plants produced at the Golden facility are marketed by big box stores within a shipping radius of 600 miles Left: Tagawa Greenhouse is currently using the FlexAIR machine to produce all its 102-cell trays which account for about 35-40 percent of the cuttings produced with the FlexAIR site manager at Tagawa Greenhouse in Golden said the Ellepot FlexAIR machine has sped up the rooting process for vegetative cuttings by four to five days across all varieties and species - Photos courtesy of Tagawa Greenhouse Ellepots for vegetative propagationTagawa Greenhouse has about 50 acres of greenhouse production in Colorado “We produce about 90 percent of our inputs internally which is all the young plants that we need for our bedding production,” said Carlos Castillo Our facility in Brighton is dedicated to propagating seedling transplants.” Tagawa Greenhouse has been using Ellepots to root its PowerStarts vegetative liners at the Golden facility since it began vegetative propagation there in 2016 Fully-automated Ellepot NGL machine a 23mm in a 102-cell tray and a 40mm in a 50-cell tray,” Castillo said “We use a fully-automated Ellepot NGL machine for our 40mm 50-cell liner tray production We are using the same Ellepot propagation mix from Lambert for all of the Ellepot production when Tagawa Greenhouse switched to the Lambert Ellepot propagation mix and FlexAIR machine to propagate its cuttings there was a substantial difference in rooting times.  Right: Using the FlexAIR machine to propagate its vegetative cuttings has enabled Tagawa Greenhouse to reduce the whole production process from sticking to shipping.   Upping vegetative propagation with FlexAIRTwo years ago Tagawa Greenhouse began using a fully-automated Ellepot FlexAIR machine to produce its soft-filled liners in 23mm Ellepots in 102 trays “When we initially heard about the FlexAIR one of its benefits was that the Ellepots produced by the machine would be soft-filled and easy to stick the cuttings in,” Castillo said “Using the Ellepot trays developed by Blackmore enabled us to cut down on our crop times The FlexAir machine Offshore propagators“About 80 percent of our vegetative unrooted cuttings come from offshore propagators a lot of the unrooted cuttings arrive at the greenhouse late which makes rooting the cuttings quickly even more important One of our biggest challenges before we began operating the FlexAIR machine We needed every minute on the bench to root in the cuttings.” and New Guinea impatiens root relatively quickly the number of days that we have for propagation did not allow us to do that,” he said “These crops are on the bench for 14-15 days The cuttings need to be stuck and placed on the bench so they can root in quickly They need to be placed in the proper environment so they can root out in order for us to ship the cuttings on time Previously we were struggling with some crops to root out on time.” Faster rooting with FlexAIRThe FlexAIR machine has sped up the rooting process by four to five days across all varieties and species “Most of the crops we propagate are shipped out in five weeks,” Castillo said “We also have some crops with three-week crop times “The cuttings we are sending out to our customers are much better rooted We see the benefits of the FlexAIR machine throughout the whole production process The time for all these processes has been reduced.” Tagawa Greenhouse is currently using the FlexAIR machine to produce all its 102-cell trays “The 102-cell trays account for about 35-40 percent of the cuttings produced with the FlexAIR,” Castillo said “We are looking for opportunities to increase production all the time Demand drives what type and size of plugs we produce If there is increased demand for the Ellepots Another benefit of the FlexAIR comes in its operation.“The FlexAIR only needs one person to operate,” Castillo said “It is very efficient and able to keep up with the Ellepots needed to meet the demand for the cuttings we are rooting.” Another benefit of the FlexAIR machine is it is very efficient and only needs one person to operate to produce the Ellepots needed to meet the demand for the cuttings Tagawa Greenhouse is rooting.  Faster rooting for grower customersAlthough Tagawa Greenhouse doesn’t receive feedback directly from growers who purchase its rooted vegetative cuttings Castillo said the company has seen an improvement in the quality notifications it receives “Once we switched to the Ellepot propagation mix and FlexAIR to root the cuttings the FlexAIR can reduce crop time overall for a lot of our customers Growers who are starting with our Ellepot plugs should see faster rooting plants which can help speed up their finishing times “We always try to do the best for our customers We do not ship any cuttings that are not up to spec in regards to our quality The FlexAIR machine and Ellepots have made that easier to do.” Lars Jensen at Blackmore Company said when Tagawa Greenhouse came to his company about its issue with rooting cuttings he knew the FlexAIR machine would be able to improve the rooting times “It’s all about knowledge and attitude,” Jensen said and they trusted us to solve it by switching them to producing soft-filled Ellepots using the FlexAIR machine at 1/3 to 1/4 the cost of most other rooting media “Another consideration is the design of the tray and its cells Ellepots conform to the cells ensuring even irrigation and uniform rooting Each cell of the trays we design for specific purposes This applies to our standard propagation trays and our patented Air Trays David Kuack is a freelance technical writer in Fort Worth For more information: Tagawa Greenhouse Enterprises, https://www.tagawagreenhouse.com Blackmore Company[email protected]www.blackmoreco.com www.air-trays.com   FreshPublishers © 2005-2025 HortiDaily.com (KGUN) — Toru Tagawa has been an orchestra director at CDO High School since 2008 started when he was just six years old in Japan So I was hooked from that point on," he said and launched a professional career performing in symphony orchestras He explained that conductors take a group of individual musicians to craft a united sound He calls it having an "orchestra mentality" "It's kind of how society works in some ways," he said "We make music performance together as a group and everybody in that group has to participate to make the product better." So he strives for every single student to become a team player I want that orchestra mentality to go into the community," he said But achieving a united sound is more difficult during this pandemic His podium has moved to a different platform -- a digital one Though still working to create a united sound "Two violins playing together it makes the sound so much better And with online learning I can't give that same sensation He's now being recognized for his contributions to education and society And he also gives credit to his other team -- the team of teachers and administrators at CDO "We walk together to make the product possible," he explained Report a typo Log in to your Television Academy account: If you're seeking ways to connect with working television industry professionals joining our organization offers you unparalleled access Learn more about Television Academy Membership click below to start the application process After a lifetime of bad guy roles and a dream role in Man in the High Castle Cary-Hiroyuki Tagawa is spreading martial healing Cary-Hiroyuki Tagawa forged a busy TV and film career by often inhabiting stereotypical Asian bad-guy roles So it's little wonder that he calls his role in Amazon's The Man in the High Castle "the most fulfilling in my career." Born in Japan and raised mostly in the U.S. Tagawa brings his bicultural background to this thought- provoking piece of alternative historical fiction As the compassionate and multifaceted Japanese trade minister Tagomi in High Castle the deeply spiritual actor gets to spread his wings "The character is absolutely Japanese," Tagawa says "In that sense it's been most satisfying bringing my life experience to this role I'm massively thankful for this opportunity." might have looked like in the '60s had Japan and Germany prevailed in World War II Tagawa's Japanese-American father was a career member of the U.S His Japanese mother defied family expectations by joining the Japanese theater as an actress Tagawa spent much of his early years moving between various schools for military families in states such as North Carolina and Texas He faced racism and contempt from some of his peers he channeled residual rage from those early experiences into villainous roles such as the sorcerer Shang Tsung in 1995's Mortal Kombat if they're going to offer me bad-guy roles I'm going to give them bad guys like they had never seen before," he says "I'm going to scare the hell out of them especially after having grown up watching so many weak Asian bad guys in film and television." Tagawa is much more about healing and spirituality He's developing a new discipline that embraces the therapeutic rather than the competitive aspect of martial arts he seems as excited about teaching the healing arts as he is acting "I made a vow when I got into Hollywood that if I ever gained any notoriety I would bring my energy back to healing," he says This article originally appeared in emmy magazine Prostate cancer is the second most common cause of death due to cancer in men in the United States Researchers at Weill Cornell Medicine have led a phase 1 trial of a new drug that delivers potent radiation therapy directly and specifically to cancer cells in patients with advanced prostate cancer. The clinical trial showed that the “radiopharmaceutical” was well tolerated and demonstrated promising antitumor activity, according to a new study published on Nov professor emeritus of urology at Weill Cornell Medicine This antibody targets prostate cancer cells anywhere in the body while avoiding healthy tissues and organs “Despite considerable advances to improve prostate cancer survival, there is no cure yet for metastatic prostate cancer,” said lead author and principal investigator of the trial Dr. Scott Tagawa a professor of medicine and medicine in urology at Weill Cornell Medicine and  medical director of the genitourinary oncology program at NewYork-Presbyterian/Weill Cornell Medical Center “Our results from this first-in-human study of a PSMA-targeted alpha emitter are very exciting and a testament to more than two decades of translational research at Weill Cornell Medicine.” For those whose cancer has spread (metastasized) to other areas of the body and does not respond to therapies that lower testosterone scientists at Weill Cornell Medicine radiolabeled J591 with beta particle emitters 177Lu-J591 effectively targeted metastatic sites with acceptable toxicity and showed encouraging signs of response and improvements in overall survival Bander’s lab has also investigated J591 attached to another molecule called actinium which emits alpha particles “Actinium is about four thousand times more potent and has a shorter delivery range than lutetium delivering more energy to kill cancer cells with less harm to surrounding healthy tissue,” Dr Tagawa conducted the phase 1 study of 225Ac-J591 between October 2017 and January 2021 at Weill Cornell Medicine and Tulane University School of Medicine A total of 32 patients with metastatic prostate cancer received a single injection of the radiopharmaceutical: 22 patients received one of seven escalating dose levels and then 10 patients in the expansion group received the highest dose The researchers found 225AC-J591 had good antitumor activity against advanced metastatic prostate cancer and was well tolerated Prostate-specific antigen (PSA)—an indication of cancer severity—decreased by at least half for 47 percent of patients 13 of 22 (59 percent) patients experienced a drop in circulating tumor count These results are encouraging signs that the treatment was working to destroy prostate cancer cells Most high-grade adverse events involved low blood cell counts As the highest dose level of 225Ac-J591 that could be given without severe side effects was not reached and only one dose was administered in the phase 1 trial a follow-up combined phase 1/phase 2 study is now underway The new study will further assess its safety and efficacy with split or multiple infusions at higher cumulative doses “These strong results are due to the multidisciplinary collaboration between medical oncologists and our nuclear medicine group,” said Dr co-leader of the Experimental Therapeutics Program at the Sandra and Edward Meyer Cancer Center and a member of the Englander Institute of Precision Medicine “We look forward to continuing to advance 225Ac-J591 in a combined phase 1/phase 2 follow-up study and future trials 225Ac-J591 may offer new hope for patients with metastatic prostate cancer.” Cornell University has exclusively licensed this technology to Convergent Therapeutics, Inc., a clinical stage pharmaceutical company focused on developing next-generation radiopharmaceutical therapies for prostate and other cancers. Convergent is one of many startups launched with foundational technology developed at Weill Cornell Medicine. The office of Enterprise Innovation which accelerates the translation of scientific discoveries into medical breakthroughs played a crucial role in the licensing of this technology to Convergent This study was supported in part by funding from Weill Cornell Medicine (via philanthropic donors) Prostate Cancer Foundation Challenge Award National Institutes of Health 1P50CA211024-01 (WCM PC SPORE Developmental Research Project) Department of Defense W81XWH-17-PCRP-IA and W81XWH-14-2-0159 PCRP-CCA (Prostate Cancer Clinical Trials Consortium) Many Weill Cornell Medicine physicians and scientists maintain relationships and collaborate with external organizations to foster scientific innovation and provide expert guidance. The institution makes these disclosures public to ensure transparency. For this information, see the profiles for Dr. Scott Tagawa and Dr. Neil Bander Back to News Hiroyasu Tagawa had no intention of breaking his silence about his terrible experience as a child of the U.S He didn't want to relive the memories of Aug 1945 and its aftermath and even avoided uttering the words "atomic bomb." Tagawa spent years regretting taking his father to a temporary first aid station where his feet were amputated with a carpenter's saw on the day of Japan's surrender in World War II His father had suffered severe burns to his feet when chemicals spilled in a factory as a result of the blast "It hurts!" This was the first expression of raw emotion by a man who until the amputation had endured the pain wordlessly and it continued to haunt Tagawa in the following years "Had I done my best for him?" Tagawa recalled having repeatedly asked himself "I wondered if I had done wrong by taking him over there Such regrets felt like thorns in my heart." Tagawa's reunion at the age of 77 with the nurse who was present during his father's amputation surgery gradually led to him breaking his silence about the bitter experience The nurse explained his father let out words of pain when a spinal anesthetic injection was administered and that the doctor had to use the saw because no other surgical tools were available at last I began to forgive myself and free my heart from all these troubling regrets." Tagawa's story has joined the collected accounts of other survivors of the atomic bombing of Nagasaki His tale is told in a "kamishibai" picture story show -- a form of storytelling popular with children before the emergence of television -- that has been digitalized and uploaded to YouTube to reach a wider audience in the age of the internet and smartphones and the Future," the roughly 20-minute clip consists of 28 picture slides each drawn by local students at Mikawa junior high school It is available in English as well as Japanese so that its message can resonate abroad as well as at home The students took about four months to finish off the original picture story show which depicts how Tagawa survived the atomic bombing and the mental impact on him thereafter according to a Nagasaki city official involved in the project This year marks the 73rd anniversary of the 1945 atomic bombings of Hiroshima on Aug The aging of "hibakusha," as survivors are known in Japanese has made it ever more urgent to record untold stories and pass them down to future generations Educating youngsters about the nature of the atomic bombing in Nagasaki which had killed nearly 74,000 by the end of 1945 and raising awareness at home and abroad are taking on greater importance "What is the best way for hibakusha stories to get passed down This is the most difficult part," said Ayaka Mine "It's true that some hibakusha prefer photos to expose the truth," Mine said "But the pictures drawn by students are soft and not too sophisticated at times Nagasaki has been trying to deepen understanding of the atomic bombing calling for the abolition of nuclear weapons translates its mayor's peace declaration on Aug with this year's declaration coming at a time when North Korea's pledge to denuclearize has grabbed global attention the Nagasaki Atomic Bomb Museum has made its leaflets available in French and Russian since last year Roughly 20 percent of all leaflets given out to visitors in fiscal 2017 through March were in those five languages the museum is one of the city's most famous spots for visitors from the rest of Japan and abroad and introduces Nagasaki's history before and after the bombing Local residents say Nagasaki has seen an increase in the number of foreign tourists in recent years particularly from Asian neighbors such as China Lin Yihsuan from Taiwan decided to visit Nagasaki during her recent trip to the Kyushu region in southwestern Japan She studied Japanese history and the atomic bombing of Nagasaki when she was a junior high school student and wanted to visit at least once "We need to pass it down because it was an important event (in history)," Lin said But with the easily accessible digital kamishibai an actual visit may not be the only way to learn Nagasaki's history "Our digital kamishibai does not target a specific audience," said Mine But having an English version "raises the chances of reaching more people." That would also reinforce Tagawa's belief in the power of one person making a difference in the life of another To have the latest news and stories delivered to your inbox Simply enter your email address below and an email will be sent through which to complete your subscription Please check your inbox for a confirmation email Thank you for reaching out to us.We will get back to you as soon as possible Keep in touch with NewYork-Presbyterian and subscribe to our newsletter It’s a disease so pervasive that many people don’t realize its severity While it’s true that most of those who are diagnosed with prostate cancer do not die of it — 2.9 million who’ve had the disease are alive today — chances of long-term survival plummet if the cancer spreads thanks to a new therapy offered in clinical trials at NewYork-Presbyterian/Weill Cornell Medical Center known as directed radioisotope therapy Because it precisely targets cancerous prostate tumors without harming other cells it holds promise for effectively treating men for whom surgery or radiation alone is not necessarily the best option “We haven’t been curing men with metastatic prostate cancer,” says Dr. Scott Tagawa an associate attending physician at NewYork-Presbyterian/Weill Cornell Medical Center and an associate professor of clinical medicine and urology and the medical director of the Genitourinary Oncology Research Program at Weill Cornell Medicine we can potentially help those who couldn’t be cured before “There are plenty of high-risk cases where surgery or radiation is not curative,” he explains “Something that could track down and kill the rogue cells outside of the prostate could increase the cure rate in combination with surgery or prostate radiation Prostate tumors are marked by something called PSMA which stands for prostate-specific membrane antigen a protein that sits on the surface of the cancer cell “Prostate cancer is one of the very few cancers in the world that has something located on the cancer cell and basically nowhere else in the body,” says Dr That’s important because it means that PSMA can serve as a marker or identifier for prostate cancer cells — a big red X marking the spot which basically “hang out over the side of the cell,” as Dr provide an ideal target for anti-PSMA antibodies or small molecules that act as “carriers” designed to recognize and bind with PSMA the anti-PSMA antibodies merge with the PSMA on the prostate cancer cells like a lock and key “These courier antibodies … can carry whatever we want to put on them whether a small radioactive particle or a chemotherapy drug,” says Dr “We inject them into a patient’s bloodstream and they go straight to the PSMA on the cancer cells killing the tumors without harming surrounding healthy cells in the prostate or in other areas of the body.” and this novel therapy is also creating new hope for better “What often happens is that a patient’s PSA number goes up but we can’t see anything on an MRI or PET scan,” says Dr (PSA is a protein made by the prostate gland; high levels in a blood test may indicate cancer.) attaching a radiotracer to an anti-PSMA antibody or small molecule allows physicians to “see” the PSMA on the cancer cells in hiding the ones responsible for the rising PSA numbers This kind of imaging can also pinpoint more aggressive tumors so treatment can be tailored accordingly — thanks again to PSMA “PSMA tends to be higher per cell in more aggressive tumors and in those that have spread beyond the prostate,” says Dr “We take advantage of that by using PSMA imaging to find these ‘hot spots’ in the body.” The more hot spots that appear on the scan the more aggressive the cancer is likely to be That knowledge is especially crucial for patients who may be taking a watch-and-wait approach to their treatment undergoing periodic monitoring rather than radiation or chemo Hot spots are like an early-warning system that suggests stronger measures are needed Stronger measures generally mean a high dose of radiation or chemo a raft of studies at NewYork-Presbyterian and other cancer centers has shown that when it comes to prostate cancer Most men who get radiation are cured,” says Dr spreading throughout the prostate and beyond If higher doses of radiation are necessary it can damage the rest of the body if not carefully targeted That led NewYork-Presbyterian and Weill Cornell Medicine physicians to a new strategy: combine a radioisotope with a small molecule that binds to PSMA This therapy would enable physicians to specifically target the PSMA-expressing cancer and minimize damage to healthy organs and tissue Tagawa and his team began conducting trials in which patients are injected with this highly targeted form of radiation therapy The radioactive particle known as lutetium-177 is attached to a small molecule called 617 — the PSMA-seeking missile The duo is then injected into the bloodstream of men with metastatic prostate cancer Successive groups of patients will continue to get ever-higher doses for better results “We’ll keep going up until we start to see any significant side effects,” says Dr we can even try attaching both radiation and a drug.” Some refer to this type of high-tech cancer treatment as “personalized medicine.” Dr this would be the most tumor-targeted treatment out there — only going to places where PSMA exists,” says Dr “And the nice thing about prostate cancer is that it’s pretty much the only site in the body with a significant amount of PSMA.” using anti-PSMA carriers and PSMA-sensitive radioisotopes to seek and destroy tumor cells should work for 90 percent of patients “As long as we can get a high enough dose of radiation to the tumor the cell will die and we can avoid the rest of the body,” he explains “This is going to help a lot of people around the world.” Keep in touch with NewYork-Presbyterian and subscribe to our newsletter.