and Vancouver Whitecaps’ Tate Johnson battle for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps’ Ralph Priso (13) challenge for the ball during the second half of an MLS soccer match Saturday Vancouver Whitecaps’ Sebastian Berhalter (16) and St Louis City’s Cedric Teuchert collide while battling for the ball during the second half of an MLS soccer match Saturday Vancouver Whitecaps’ Tristan Blackmon (33) passes around St Louis City’s Marcel Hartel during the second half of an MLS soccer match Saturday Vancouver Whitecaps’ Édier Ocampo yells after being injured during the second half of an MLS soccer match against St Louis City’s Conrad Wallem (6) and Vancouver Whitecaps’ Édier Ocampo (18) battle for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps’ Emmanuel Sabbi battle for the ball as St Louis City’s Conrad Wallem (6) watches during the first half of an MLS soccer match Saturday LOUIS (AP) — Yohei Takaoka made two saves for Vancouver on Saturday night to help the Whitecaps play St Vancouver (6-1-2) has allowed just one goal during its current four-game unbeaten streak dating to a 3-1 loss to the Chicago Fire on March 22 Goalkeeper Ben Lundt made his sixth consecutive start in place of the injured Roman Bürki and finished with a save Office sought: Vernon Hills village board (Vote for 3) Previous offices held: Vernon Hills Village Trustee since 2017 What is the most serious issue your community will face in the coming years and how should the village board respond to it Managing the growth of our community both from a residential and commercial perspective The village staff in place is phenomenal and relatively new Our police department led by Chief Patrick Kreis has great leadership as well maintaining a very safe environment during this growth period I am confident they will continue what has been established over the previous years of Vernon Hills' tremendous growth The village board is very fortunate to work with such a tremendous group of people at the village led by Kevin Timony and Jon Petrillo How would you describe the state of your community's finances What should be the top priorities for spending during the next few years Are there areas of spending that need to be curtailed We are very fortunate to have such a strong sales tax base along with a very fiscally responsible Village staff that will allow Vernon Hills to continue to prosper We are continuing to grow residentially and commercially in a responsible way which will allow us to avoid a municipal property tax that other communities have We will continue to allocate funds and resources for the betterment of the community What do you see as the most important infrastructure project the community must address what project(s) can be put on the back burner We continue to improve our infrastructure on a continuous basis without any major financial hurdles due to our strong financial position this is due to the continued growth in our community Describe your experience working in a group setting to determine policy What is your style in such a setting to reach an agreement and manage local government Explain how you think that will be effective in producing effective actions and decisions with your village board I have had the pleasure the past eight years to work with a strong village staff that makes our decision making process seamless I believe my experience as both a business owner and private sector allows me to bring insight to the staff and board with all of the growth that has been occurring the past eight years What makes you the best candidate for the job My eight years experience as a village trustee working with previous and current staff along with my business background in the private sector and as a business owner What’s one good idea you have to better the community that no one is talking about yet I would like to hold town hall meetings where more input from the community on what the village should focus on is something I would like to implement Sign In Register winning an early corner after some neat interplay between Ali Ahmed and Tate Johnson on the left wing Pedro Vite whipped in the ensuing set piece to Emmanuel Sabbi who saw his volleyed effort deflect just wide of the St as he picked up a loose ball at the top of the box and unleashed a stinging left-footed shot narrowly wide of the top left corner Louis thought that they took the lead in the 25th minute after Conrad Wallem crossed it to Marcel Hartel at the back post Ahmed came close to getting the first goal of the night just past the half-hour mark but his shot was blocked behind for a corner Joao Klauss nearly got the go-ahead goal right before halftime flicking on a free-kick delivery toward goal but Takaoka came up big with a massive stop from point-blank range Whitecaps FC kept fighting hard at the end of the half The second half began with both teams searching for the difference Édier Ocampo had an effort in the 55th minute firing a low shot from the edge of the box after the ball bounced out of the box toward him but it was deflected behind for a corner-kick Substitute Daniel Ríos came close to getting that long-awaited first goal after Ahmed used the outside of his boot to curl a cross toward the onrushing striker at the near post The 'Caps kept pounding at the door in the latter stages of the match throwing numbers forward in search of a winner The Whitecaps are back in action on Thursday for the first leg of their CONCACAF Champions Cup semifinal against Inter Miami CF at B.C AP soccer: https://apnews.com/soccer Motokuni Takaoka - EY World Entrepreneur Of The Year™ 2025 Judge Asking the better questions that unlock new answers to the working world's most complex issues AI insights CFO agenda EY Center for Board Matters EY podcasts EY webcasts Operations leaders Technology leaders EY helps clients create long-term value for all stakeholders our services and solutions provide trust through assurance and help clients transform EY.ai - A unifying platform Strategy, transaction and transformation consulting Technology transformation Tax function operations Climate change and sustainability services EY Ecosystems EY Nexus: business transformation platform Experienced professionals EY-Parthenon careers Student and entry level programs Talent community our purpose is building a better working world The insights and services we provide help to create long-term value for clients The EY Global IPO Trends covers the news and insights on the global area and regional IPO markets for Q1 2025 and an outlook Leaders that put humans at the center to navigate turning points are 12 times more likely to significantly improve transformation performance Back to the EY World Entrepreneur Of The Year™  - Judges Motokuni Takaoka is the Chairman and CEO of Airweave which he founded to find better sleep solutions after suffering chronic neck pain from a car accident He had taken over his uncle’s fishing line business in 2004 and was inspired by the resin fiber used in the lines a revolutionary resin-based sleep technology designed to replace traditional spring mattresses He partnered with Stanford University to incorporate science-backed sleep research into the development process Initially embraced by athletes for their superior quality hygienic and customizable mattresses transformed the stagnant bedding industry The innovative bedding gradually gained popularity with the public and has become one of Japan’s leading mattress brands Airweave boasted over 400 stores in Japan and recorded sales of US$1.34b Airweave has made its mark at several Olympic Games The brand’s mattresses were a feature of the Tokyo 2020 and Paris 2024 athlete villages and will be used at the Milano-Cortina 2026 Olympics Airweave has expanded beyond Japan to markets in the United States continuing its mission to bring “Quality Sleep” to the world Motokuni is EY Entrepreneur Of The Year™ 2016 Japan of the member firms of Ernst & Young Global Limited Discover the insights you need to make better decisions today EY.ai - A unifying platform Technology transformation Tax function operations Climate change and sustainability services EY Ecosystems EY Nexus: business transformation platform As cautious CEOs navigate trade wars and tariffs strategic leaders can use M&A as a long-term value driver Discover how shifts in demographics and tech reshape priorities urging new models for growth through innovative organizational strategies The sixth EY Climate Action Barometer shows an increase in companies reporting on climate but falling short of carbon ambitions Back to the EY World Entrepreneur Of The Year™  - Judges The last three years have been personally difficult for Vernon Hills Village President Roger Byrne Less than a year after taking office for his eighth term a rare but extremely serious autoimmune condition in which the body essentially attacks itself It is no understatement to say that despite remarkable and courageous progress on his recovery His initial treatment required lengthy time on a ventilator and was followed by complications with heart disease and the COVID virus Byrne has remained sharp and focused mentally and his continued devotion to Vernon Hills is nothing short of inspirational we were impressed by his continued grasp of village issues and by the fervor of his interest in them He is completing his 32nd year as village president after serving six years as a trustee on the village board he has been a presence in Vernon Hills for more than half of its 67-year existence He has had a hand in so much of the strength vitality and sense of community you see in town Byrne is stepping back some in recognition of his health challenges He is on the ballot to run for one of three trustee seats on the village board is running unopposed to take his place as village president Koch has acted as chairman pro tem at most village board meetings Byrne attended digitally until his health progressed enough to allow him recently to make occasional appearances in person four candidates are running for three trustee seats on the village board — Byrne recently retired after a lengthy career as a village employee but these are easy endorsements to make: Byrne and they have given us no reason to regret our recommendations Each has played a role in the impressive transformation of the Hawthorn Mall campus and the diversification of the village's economic base Vernon Hills is a model suburb in Lake County Schenk and Takaoka deserve some credit for that Lundeen has the community interest at heart and perspective on village operations But she lacks the mastery of issues her adversaries offer and fails to make a case why any of them should be replaced Cloudy skies early followed by heavy thunderstorms late and Vancouver Whitecaps' Tate Johnson battle for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps' Ralph Priso (13) challenge for the ball during the second half of an MLS soccer match Saturday Vancouver Whitecaps' Sebastian Berhalter (16) and St Louis City's Cedric Teuchert collide while battling for the ball during the second half of an MLS soccer match Saturday Vancouver Whitecaps' Tristan Blackmon (33) passes around St Louis City's Marcel Hartel during the second half of an MLS soccer match Saturday Vancouver Whitecaps' Édier Ocampo yells after being injured during the second half of an MLS soccer match against St Louis City's Conrad Wallem (6) and Vancouver Whitecaps' Édier Ocampo (18) battle for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps' Emmanuel Sabbi battle for the ball as St Louis City's Conrad Wallem (6) watches during the first half of an MLS soccer match Saturday Yohei Takaoka made two saves for Vancouver on Saturday night to help the Whitecaps play St Vancouver (6-1-2) has allowed just one goal during its current four-game unbeaten streak Javascript is required for you to be able to read premium content rewritten or redistributed without permission there are no recent results for popular commented articles Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Account processing issue - the email address may already exist Sign up to receive a daily list of Obituary notifications Signup today for the Harker Heights Herald Would you like to receive sports news from all the schools we cover Would you like to receive news about the Copperas Cove Bulldawgs Would you like to receive news about the Belton Tigers Would you like to receive news about the Ellison Eagles Would you like to receive news about the Florence Buffaloes Would you like to receive news about the Gatesville Hornets Would you like to receive news about the Harker Heights knights Would you like to receive news about the Killeen Kangaroos Would you like to receive news about the Lampasas Badger Would you like to receive news about the Lometa Hornets Would you like to receive news about the Midway Panthers Would you like to receive news about the Salado Eagles Would you like to receive news about the Shoemaker Grey Wolves Invalid password or account does not exist Submitting this form below will send a message to your email with a link to change your password An email message containing instructions on how to reset your password has been sent to the email address listed on your account Metrics details the precise mechanisms behind this increased ASCVD risk are not understood Here we find that early intermittent feeding of mice on a high-cholesterol Western-type diet (WD) accelerates atherosclerosis compared with late continuous exposure to the WD despite similar cumulative circulating LDL-C levels We find that early intermittent hyperlipidaemia alters the number and homeostatic phenotype of resident-like arterial macrophages Macrophage genes with altered expression are enriched for genes linked to human ASCVD in genome-wide association studies We show that LYVE1+ resident macrophages are atheroprotective and identify biological pathways related to actin filament organization of which alteration accelerates atherosclerosis we show that exposure to cholesterol early in life is significantly associated with the incidence and size of carotid atherosclerotic plaques in mid-adulthood our results identify early intermittent exposure to cholesterol as a strong determinant of accelerated atherosclerosis highlighting the importance of optimal control of hyperlipidaemia early in life and providing insights into the underlying biological mechanisms This knowledge will be essential to designing effective therapeutic strategies to combat ASCVD the precise mechanisms that are responsible for the development of inflammatory plaques in response to cholesterol overload are not well understood The questions therefore regard (1) how early and intermittent variations in serum cholesterol increase ASCVD risk; and (2) how this can be modelled to understand the underlying mechanisms Here we have begun to answer these important questions Since Ignatowski developed the first animal model of diet-induced atherosclerosis in 1908 these models have mostly relied on inducing sustained elevations in circulating cholesterol levels for a defined period of time until the experiment is terminated for analysis of plaque size and characteristics these models address the effect of ‘late’ hyperlipidaemia (that is late during lifetime) on the development of atherosclerosis but ignore the potential effect of lifelong variable exposure to circulating cholesterol on disease development and progression The mean atherosclerotic plaque size in the aortic sinus of the two groups of mice at the end of the experiment is shown Ldlr−/−Rag2−/− male mice on a normal diet were put on a cWD versus iWD diet for 6 weeks Statistical analysis was performed using two-tailed unpaired t-tests (d and f–h) Source Data early exposure to WD is substantially more pro-atherogenic than late exposure our results suggest a limited effect of gut microbiota on iWD-induced acceleration of atherosclerosis Although the roles of specific T and B cell subsets require additional studies our results suggest a critical role of non-adaptive immune responses in this process The percentages of adventitial LYVE1+CD68+ macrophages among adventitial CD68+ macrophages Statistical analysis was performed using two-tailed unpaired t-tests suggesting a predominantly phenotypic alteration of these macrophages at this early timepoint protects against the development of atherosclerosis our data suggest that alteration of resident-like arterial macrophages is involved in the acceleration of atherosclerosis in response to early intermittent hyperlipidaemia supporting the clinical relevance of our findings Quantification of the atherosclerotic lesion size (f and j) and necrotic core area (g and k) in the aortic root Plasma cholesterol levels at the end of the experiment Statistical analysis was performed using two-tailed Mann–Whitney U-tests (b–d,g,h and j–l) The mean atherosclerotic plaque size in the aortic sinus is shown our data point to actin filament organization and NRP1 expression in macrophages as potentially important targets the alteration of which may be causally linked to iWD-dependent acceleration of atherosclerosis the role of myeloid NRP1 in atherosclerosis is unclear our data implicate NRP1 as part of a biological pathway that affects the arterial macrophage cytoskeleton and becomes altered in response to early intermittent hyperlipidaemia leading to acceleration of atherosclerosis noting that the credible intervals for each life stage were wide and overlapped Although there was some suggestion that exposure to non-HDL-C at adolescence and young adulthood was contributing most to the observed lifetime effects exposure to non-HDL-C levels before adulthood (that is childhood and adolescence) consistently contributed more than half of the lifetime effect to plaque outcomes in mid-adulthood This suggests that exposure to cholesterol before adulthood contributes to the development of atherosclerosis in mid-adulthood We found that intermittent hyperlipidaemia can still accelerate atherosclerosis after extended durations of a high-fat diet long after the early alteration of resident macrophages This suggests that alteration of resident macrophages sets the stage for further acceleration of atherosclerosis by additional mechanisms which become revealed by the absence of resident macrophages This hypothesis merits further investigation the use of Lyz2cre+/− also affects gene expression in neutrophils Nrp1 and Spic show very low or no expression the results using Lyz2cre+/−Nrp1flox/flox and Lyz2cre+/−Spicflox/flox mice can mostly be attributed to the roles of NRP1 and SPIC in macrophages Note also that efferocytosis was not directly assessed in plaque-derived macrophages although the human data show that hyperlipidaemia early in life determines future atherosclerotic plaque development these data are observational and are subject to bias and confounding and additional studies will be required to address the effect of cholesterol variability in childhood or adolescence on plaque development and progression Lyz2cre+/−Nrp1flox/flox and Lyz2cre+/−Nrp1+/+ mice were generated by the group of Christiana Ruhrberg Cx3cr1creERT2/+Rosa26LSL-TomatoLdlr−/− mice were generated by J Apoe−/− mice were purchased from Comparative Medicine (National University of Singapore) Lyve1cre/cre and Csf1rflox/flox mice were purchased from Jackson Laboratory Apoe−/−Lyve1cre/WTCsf1rflox/flox mice were generated by crossbreeding Lyve1cre/cre with Apoe−/−Csf1rflox/flox mice 8–10-week-old Lyve1cre+/WTCsf1rflox/flox and Csf1rflox/flox female mice were injected intraperitoneally with 0.5 × 1012 viral genome copies of AAV8-D377Y-mPCSK9 virus per mouse to induce hypercholesterolemia AAV8-D377Y-mPCSK9 viruses were purchased from and generated by Phoenix Laboratory of Gene Therapy and Cell Therapy (National University of Singapore) Mice were randomly assigned to their respective experimental groups Sample size was determined to detect a significant difference (α = 0.05 and 80% power) of at least 30% in lesion size between groups Analyses were performed in a blinded manner Main atherosclerosis experiments were repeated several times and showed consistent results (see the main text) All animals were maintained in pathogen-free animal facilities and were handled in accordance with protocols approved by local institutional animal care and use committees Mice were housed under a 12 h–12 h dark–light cycle at ambient temperature of 22 °C and 45–65% humidity No wild animals and no field-collected samples were used in the study Ldlr−/− mice were irradiated with two doses of 5.5 Gy (separated by 4 h) followed by reconstitution with 0.5–1 × 107 sex-matched donor bone marrow cells Animals were randomly assigned to receive the appropriate bone marrow Mice were then maintained for a 4-week recovery period before being continued on normal or WD (21% fat Blood was obtained from through the saphenous vein (during the experimental period) or the vena cava (at euthanasia) on EDTA Plasma was separated by centrifugation at 12,000 rpm and kept at −80 °C Lipids (and corticosterone) were measured by the Core Biochemical Assay laboratory at the University of Cambridge and using a commercially available cholesterol colorimetric assay kit (BioVision) The adventitial area of the innominate artery section was demarcated as the area between GFP autofluorescence of the external elastic laminae and the border of the periadventitial fat The extent of plaque spread was determined by the measurement of external elastic laminae length beneath the plaque Necrotic area was determined by demarcating DAPI-negative regions within plaques of the aortic sinus sections Data analysis was conducted in a blind manner where appropriate Primary antibodies used for immunofluorescence analysis included anti-MOMA2 (rabbit monoclonal 1:300) and Cy3-conjugated anti-smooth muscle actin (1A4 Rat IgG (eBioscience) and rabbit IgG (Jackson ImmunoResearch) were used for isotype controls Cy3- (1:500) and AF647 (1:300)-conjugated antibodies (Jackson ImmunoResearch) were used for fluorescence detection The apoptosis assay was performed using the Roche In Situ Cell Death Detection Kit The number of extracellular (not internalized) apoptotic cells was determined on three ×40 magnification fields of aortic sinus lesions as TUNEL+DAPI+ double-positive cells within the necrotic core of atherosclerotic plaques To examine whether NRP1 expression in macrophages affects efferocytosis bone-marrow-derived macrophages from Lyz2cre+/−Nrp1flox/flox and Lyz2cre+/−Nrp1+/+ mice were incubated with fluorescent dye PKH26-labelled apoptotic Jurkat cells (E6-1; ATCC) induced by ultraviolet irradiation macrophages were washed with PBS and then fixed with 4% paraformaldehyde The Jurkat cell line used in this experiment tested negative for mycoplasma at first provision it has not been retested later on and has not been authenticated retaining only nucleotides with a Phred quality score of at least 20 then paired-end assembled and mapped onto the different samples using the barcode information Rarefaction was performed at 4,062 reads per sample to normalize all samples to the minimum shared read count and to account for differential sequencing depth Sequences were assigned to operational taxonomic units (OTUs) using uclust and the greengenes reference database (gg_13_8 release) with 97% identity Representative OTUs were picked and taxonomy assigned using uclust and the greengenes database Quality filtering was performed by removing chimeric sequences using ChimeraSlayer and by removing singletons and sequences that did not align with PyNAST The reference phylogenetic tree was constructed using FastTree 2 Unequal read counts were normalized by rarefaction to 5,257 and 9,200 (ABx experiment) reads per sample The relative abundance was calculated by dividing the number of reads for an OTU by the total number of sequences in the sample β-Diversity was calculated using Bray–Curtis dissimilarity and visualized by principal coordinate plots 16S copy numbers were normalized per g of faecal material and to the untreated control Cx3cr1creER/+R26lsl-tdTomatoLdlr−/− reporter mice were orally gavaged with 200 µl (20 mg ml−1) tamoxifen in corn oil to induce tdTomato-expression in CX3CR1-expressing MacAIR and adventitia-resident macrophages Mice were then rested on a normal diet for 2 weeks to allow for monocyte turnover in the blood before initiating a 7 week experimental feeding period The control mice were rested for four additional weeks on a normal diet followed by three weeks on a WD (TD.88137; adjusted calories diet Mice in the intermittent feeding group underwent three cycles of iWD; this consisted of 1 week of WD followed by 2 weeks on a chow diet with euthanasia after the third week of WD feeding fixed in a 4% paraformaldehyde with 30% sucrose solution and then stained for macrophages using CD45 (30-F11 Adventitia and aortic intima were whole-mount imaged using the Leica Sp8 laser-scanning confocal microscope using LAS X software Images were processed using Imaris software (Bitplane) and quantification of cells was performed using the spot function Adventitia samples were collected at three different regions of interest (approximately 1 mm × 1 mm each) and quantification of resident adventitia cell density was averaged for each mouse Macrophages in the aortic intima were quantified by CD68 expression and MacAIR cells were identified for co-expression of tdTomato Sample imaging and quantification were performed with sample identification blinded to the researcher Total RNA was extracted from cells using the RNeasy mini kit (Qiagen) and cDNA was synthesized using the QuantiTect Reverse Transcription Kit Quantitative PCR (qPCR) was performed using the SYBR Green qPCR mix (Eurogentec) on the Roche Lightcycler Rplp0 (also known as 36B4) was used as a reference gene The primer list was as follows: mouse Nrp1 forward 5′-CATCTCCCGGTTACCCTCATTCTT-3′; mouse Nrp1 reverse 5′-TCTCCAGAGGCACCATTGAAA-3′; Rplp0 reverse Animals were perfused with cold PBS to remove any trace of blood Aortas were collected and cleaned of contaminated tissues under a dissection microscope Aortas were minced with scissors and subjected to two different enzymatic digestion methods Cell suspensions were pipetted up and down until disappearance of all residual piece of tissue and filtered through a 70 µm cell strainer single-cell suspensions of aortic cells were prepared Cell suspensions were incubated with Zombie Aqua Fixable Viability Kit (BioLegend) for 10 min at room temperature and the cells were then stained with fluorescently labelled anti-mouse antibodies against CD45 Aortic macrophages were identified as CD45+CD11b+CD64+ Peritoneal macrophages were obtained by intraperitoneal injection of cold PBS from Ldlr−/− mice reconstituted with Lyz2cre+/−Nrp1flox/flox or Lyz2cre+/−Nrp1+/+ bone marrow Peritoneal exudates were allowed to adhere to the six-well plates by culturing them for 2 h at 37 °C Nonadherent cells were removed by gently washing with warm PBS and the remaining peritoneal macrophages were used for bulk RNA-seq RNA extraction and residual DNA removal after DNase digestion was performed using the RNeasy mini kit (Qiagen) according to the manufacturer’s instructions After quality checking using the Agilent Bioanalyser 2100 system total RNA was made into sequencing libraries we used the Takara SMART-Seq v4 Ultra Low Input RNA Kit total RNA was fragmented before reverse transcription Second-strand cDNA was PCR synthesized with the incorporation of SMART technology cDNA originally from rRNA was removed selectively before Illumina-compatible barcoded libraries were generated by PCR amplification pooled and were sequenced on the Illumina HiSeq 4000 platform total RNA was purified using poly-T oligo beads and fragmented before reverse transcription After adenylating 3′ ends and ligating the adapter pooled and were sequenced on the Illumina NovaSeq 6000 platform All sequencing was performed at the Genomics Core Facility The enrichment P value was calculated using the hypergeometric distribution with the one-side Fisher’s exact test N is the total number of genes in the background distribution M is the number of genes within that distribution that are annotated (either directly or indirectly) to the gene set of interest n is the size of the list of genes of interest and x is the number of genes within that list which are annotated to the gene set The background distribution by default is all of the genes that have annotation P values are adjusted for multiple comparison using Benjamini–Hochberg correction staining was performed without primary antibodies Stained slides were imaged using the Leica TCS SP8 3X or by DM6 B Thunder Imager (Leica Microsystems) Images were acquired under identical microscope settings using sequential acquisition of different channels to avoid cross-talk between fluorophores and non-overlapping fluorophores were used for colocalization analysis All images were prepared as TIF files and quantified using ImageJ software For quantification of LYVE1+ macrophages in the adventitia LYVE1+CD68+ macrophages among total adventitial CD68+ cells were quantified in 5–8 images per section in three sections per sample and expressed as percentage of LYVE1+ macrophages from adventitial CD68+ cells The Cardiovascular Risk in Young Finns Study is a prospective cohort study that began in 1980 when the participants were aged 3–18 years The primary sample for this analysis included up to 2,062 participants who attended the most recent 2018 follow-up when aged 41–56 years and who had carotid ultrasound studies performed a secondary sample included 2,643 participants who attended either the 2001 or 2007 follow-ups then aged 24–45 years when carotid ultrasound studies were also performed Ethics approval for the baseline study was granted by the University of Turku Faculty of Medicine Ethical Committee (letter dated 14/11/1978 minutes 3/1978) and for the most recent follow-up granted by the Hospital District of Southwest Finland (Ethics approval number ETMK:68/1801/2017) Carotid artery plaque measures were performed off-line by a single reader blinded to the participant’s details Where ultrasound data were available on participants at both 2001 and 2007 follow-ups The prevalence of plaque was 39.6% in 2018 (817 out of 2,062) and 3.3% (88 out of 2,643) in 2001/07 Statistical analyses were performed using Graph Pad Prism 7 (Graph Pad Software) Experimental groups were compared using two-tailed Student’s unpaired t-tests or Mann–Whitney tests as appropriate P < 0.05 was considered to be significant The BRLM estimates an overall or total lifetime effect representing the maximum accumulated effect of non-HDL-C measured at different stages across the observed life-course (in this case childhood adolescence and young adulthood) on each outcome variable in mid-adulthood (β for continuous outcomes and relative risk for categorical outcomes) The BRLM also allows estimation of the relative weights and their posterior distributions for non-HDL-C measured in childhood adolescence and young adulthood that represent the direct or relative contribution of non-HDL-C at each life stage to each outcome These weight parameters help to determine the life-course model that is best supported by the data The life-course association of non-HDL-C and each outcome forms one of three prevailing hypotheses: (1) an accumulation life-course model (non-HDL-C at each life stage is having an equal contribution); or subclasses of an accumulation model; (2) a sensitive life-course model (non-HDL-C levels at each life stage has different importance); or (3) a critical life-course model (non-HDL-C at only one life stage is of importance) Using the accumulated effect and relative weight the BRLM also estimates the life-stage-specific effect 2.5) prior for the lifetime effect and a non-informative Dirichlet (1 Multiple imputation was undertaken for the covariates of youth age using predictive mean matching via the R library mice and the means and credible intervals were calculated using the draws across all imputations The rstan package of R studio (v.3.5.3, R Foundation for Statistical Computing) was used to fit the BRLM in the probabilistic programming language, Stan69 R Foundation for Statistical Computing) was used to perform the IGC modelling Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article Time course of LDL cholesterol exposure and cardiovascular disease event risk Cholesterol variability and the risk of mortality and stroke: a nationwide population-based study Associations of variability in blood pressure and body mass index with mortality and cardiovascular outcomes in the general population Visit-to-visit low-density lipoprotein cholesterol variability and risk of cardiovascular outcomes: insights from the TNT trial NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Antiinflammatory therapy with canakinumab for atherosclerotic disease Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice Subendothelial retention of atherogenic lipoproteins in early atherosclerosis semisynthetic diets in LDL receptor-deficient C57BL/6 J and FVB/NJ mice: comparison of lesions of the aortic root Impact of gut microbiota and diet on the development of atherosclerosis in Apoe−/− Mice Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein E Macrophage autophagy plays a protective role in advanced atherosclerosis A genome-wide CRISPR screen identifies WDFY3 as a regulator of macrophage efferocytosis Mechanisms and consequences of defective efferocytosis in atherosclerosis Limited proliferation capacity of aortic intima resident macrophages requires monocyte recruitment for atherosclerotic plaque progression Deficiency of macrophage PHACTR1 impairs efferocytosis and promotes atherosclerotic plaque necrosis Multiple causal variants underlie genetic associations in humans A systems biology framework identifies molecular underpinnings of coronary heart disease Integrated single-cell analysis based classification of vascular mononuclear phagocytes in mouse and human atherosclerosis Hyaluronan receptor LYVE-1-expressing macrophages maintain arterial tone through hyaluronan-mediated regulation of smooth muscle cell collagen Single-cell RNA-seq reveals the transcriptional landscape and heterogeneity of aortic macrophages in murine atherosclerosis Transcriptome analysis reveals nonfoamy rather than foamy plaque macrophages are proinflammatory in atherosclerotic murine models Dynamics of cardiac neutrophil diversity in murine myocardial infarction Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants Large-scale association analysis identifies new risk loci for coronary artery disease Myocardial infarction-associated SNP at 6p24 interferes with MEF2 binding and associates with PHACTR1 expression levels in human coronary arteries Large-scale genome-wide association study of coronary artery disease in genetically diverse populations Single-cell immune landscape of human atherosclerotic plaques Imatinib inhibits VEGF-independent angiogenesis by targeting neuropilin 1-dependent ABL1 activation in endothelial cells NRP1 regulates CDC42 activation to promote filopodia formation in endothelial tip cells Neuropilin-1 regulates a new VEGF-induced gene which controls tubulogenesis and modulates lamellipodial dynamics in human endothelial cells Discovery and systematic characterization of risk variants and genes for coronary artery disease in over a million participants Neuropilin-1 expression in adipose tissue macrophages protects against obesity and metabolic syndrome Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study Childhood risk factors and carotid atherosclerotic plaque in adulthood: the Cardiovascular Risk in Young Finns Study Cardiovascular effect of discontinuing statins for primary prevention at the age of 75 years: a nationwide population-based cohort study in France Decreased atherosclerotic lesion formation in CX3CR1/apolipoprotein E double knockout mice Self-renewing resident arterial macrophages arise from embryonic CX3CR1+ precursors and circulating monocytes immediately after birth 20-year follow-up of statins in children with familial hypercholesterolemia Eradicating atherosclerotic events by targeting early subclinical disease: it is time to retire the therapeutic paradigm of too much Two phase 3 trials of inclisiran in patients with elevated LDL cholesterol In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates Heme ameliorates dextran sodium sulfate-induced colitis through providing intestinal macrophages with noninflammatory profiles and reporting of animal atherosclerosis studies: a scientific statement from the american heart association Altered mucus glycosylation in core 1 O-glycan-deficient mice affects microbiota composition and intestinal architecture The gut microbiota modulates energy metabolism in the hibernating brown bear Ursus arctos Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms NOD2 influences trajectories of intestinal microbiota recovery after antibiotic perturbation Nextflow enables reproducible computational workflows The nf-core framework for community-curated bioinformatics pipelines Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 clusterProfiler: an R package for comparing biological themes among gene clusters clusterProfiler 4.0: a universal enrichment tool for interpreting omics data Comprehensive Integration of Single-Cell Data A Python library for probabilistic analysis of single-cell omics data Enrichr: interactive and collaborative HTML5 gene list enrichment analysis tool Enrichr: a comprehensive gene set enrichment analysis web server 2016 update g:Profiler: a web server for functional enrichment analysis and conversions of gene lists (2019 update) Neuroimmune cardiovascular interfaces control atherosclerosis ApoE attenuates unresolvable inflammation by complex formation with activated C1q Hepatic manifestations of total parenteral nutrition: need for prospective investigation A Bayesian approach to investigate life course hypotheses involving continuous exposures Disadvantageous socioeconomic position at specific life periods may contribute to prostate cancer risk and aggressiveness The combined effect of common genetic risk variants on circulating lipoproteins is evident in childhood: a longitudinal analysis of the Cardiovascular Risk in Young Finns Study Association of non-high-density lipoprotein cholesterol measured in adolescence and mid-adulthood with coronary artery calcification measured in mid-adulthood Stan: a probabilistic programming language Takaoka, M et al. Code for ‘Early intermittent hyperlipidaemia alters tissue macrophages to fuel atherosclerosis’. Zenodo https://doi.org/10.5281/zenodo.13137366 (2024) Download references is supported by a BHF chair grant (CH/10/001/27642) a BHF Special Project Grant (SP/F/20/150010) the BHF Centre of Research Excellence (RE/18/1/34212) the Leducq Foundation (20CVD03) and the NIHR Cambridge Biomedical Research Centre (NIHR203312) The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care; M.N by a BHF Intermediate Fellowship (G103314) is supported by a BHF Project Grant (PG/21/10816); and T.X.Z through the BHF (CH/10/001/27642) and by the BMA Foundation and the Academy of Medical Sciences (SGL025/1071) This work is also supported by a NMRC-funded grant to H.Y.L were supported by the American Heart Association (CDA855022) and the US National Institutes of Health (R01 AI165553); D.T by the European Research Council (ERC Starting grant) P35233) and the European Research Area Network on Cardiovascular Diseases (I4647); F.S by the German Research Foundation (DFG) through the grant SO1141/10-1 and the Research Unit FOR5042 “miTarget—The Microbiome as a Target in Inflammatory Bowel Diseases” (project P5); S.K.M through a Corona Foundation grant (S199/10087/2022) by a Wellcome Investigator Award (095623/Z/11/Z) This work is also supported by the Academy of Finland (grant numbers 286284 117787 (Gendi) and 41071 (Skidi)); the Social Insurance Institution of Finland; Competitive State Research Financing of the Expert Responsibility area of Kuopio is supported by the European Research Council (grant number 742927 for MULTIEPIGEN project) Paulon Foundation and Licentiate of Medicine Paavo Ilmari Ahvenainen Foundation; and C.G.M by a National Health and Medical Research Council (NHMRC) Investigator Grant (APP1176494) The contents of the published material are solely the responsibility of the individual authors and do not reflect the views of the NHMRC Ise for his contribution to generating the Spicflox/flox mice; J.-B Michel for providing tissue sections of healthy and atherosclerotic human coronary arteries; D Warner for providing Jurkat cells and assistance with BMDM experiments respectively; the staff at the Phenotyping Hub and Biochemical Assay Laboratory of Cambridge University Hospitals the University of Cambridge Biomedical Services at the Anne McLaren Building the Cancer Research UK Cambridge Institute Genomics Core facility and the Genomics & Bioinformatics Core Wellcome-MRC Institute of Metabolic Science-Metabolic Research Laboratories and Medical Research Council Metabolic Diseases Unit University of Cambridge; the members of the Advanced Imaging and Histology cores of Life Sciences Institute These authors contributed equally: Xiaohui Zhao Immunology Translational Research Programme Research Centre of Applied and Preventive Cardiovascular Medicine; University of Turku University of Turku and Turku University Hospital Institut National de la Santé et de la Recherche Médicale Department of Integrative Biology & Physiology University of Kiel and University Hospital Schleswig Holstein (UKSH) Ludwig-Maximilians-Universität München (LMU) Finnish Cardiovascular Research Center Tampere Department of Clinical Physiology and Nuclear Medicine led and performed most of the experiments on atherosclerosis and contributed to the RNA-seq data designed the experiments related to LYVE1+ expressing adventitial macrophages performed the corresponding experiments and analysed the data designed the analysis plan of the YFS and interpreted the data NS performed and analysed atherosclerosis experiments performed fate-mapping experiments and analysed data performed atherosclerosis and RNA-seq experiments performed 16S amplicon sequencing and analysed/interpreted corresponding data contributed to analysis of the microbiota depletion experiments performed and analysed experiments related to adventitia LYVE1+ macrophages in human coronary arteries contributed to the atherosclerosis and RNA-seq experiments maintained genetically modified mice and helped in atherosclerosis experiments mated and genotyped genetically modified mice for bone marrow donation generated and provided genetically modified mice established the required collaborations and wrote the manuscript All of the authors reviewed and edited the manuscript The authors declare no competing interests Nature thanks Sreenath Madathil and the other, anonymous, reviewer(s) for their contribution to the peer review of this work. Peer reviewer reports are available Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations LDL receptor-deficient (Ldlr−/−) male mice on normal diet were fed a Western-type diet (WD) for 6 weeks (w) either continuously (cWD) or intermittently (iWD) Calculation of plasma cholesterol levels in mice subjected to iWD over a period of 6 weeks examples are given for measurements that started at the end of week 9 and the beginning of week 10 and lasted until end of week 15 shows cholesterol measurement over 14 consecutive days (n = 4 per time point) shows weekly cholesterol measurements in Ldlr−/− mice under cWD (during the last 6 weeks weekly LDL cholesterol measurements in Ldlr−/− mice under cWD (during the last 6 weeks and plasma corticosterone levels (h) in randomly selected cWD (n = 5) or iWD (n = 6) fed Ldlr−/− mice at the end of the experiment Mean ± s.e.m.; two-tailed unpaired t-test (e-h) LDL receptor-deficient (Ldlr−/−) female mice were fed a Western-type diet (WD) for 6 weeks (w) either continuously (cWD) or intermittently (iWD) Representative photomicrographs (left panels) and mean atherosclerotic plaque size (right panel) in the aortic sinus of the 2 groups of mice are shown (n = 10 cWD and n = 11 iWD) Ldlr−/− female mice irradiated and reconstituted with WT bone marrow and subjected to 6 weeks of cWD (n = 10) or iWD (n = 8) Representative photomicrographs (left panels) and mean atherosclerotic plaque size (right panel) in the aortic sinus of the 2 groups of mice are shown Ldlr−/− male mice were put on 6 weeks cWD (n = 6) versus 6 weeks iWD (n = 6) Mean plaque area staining positively for MOMA2 (c) and Sirius red (collagen) (g) in one set of a series of experiments LDL receptor-deficient (Ldlr−/−) male mice first received 3 intermittent weeks of Western diet (WD) at the beginning of the experiment then 3 weeks of continuous WD just before the end of the experiment (n = 6) Group 2 mice received 6 weeks of intermittent WD (n = 6) Mean atherosclerotic plaque size in the aortic sinus of the 2 groups of mice (n = 6 per group) Ldlr−/− male mice were put on 12 weeks of cWD (n = 5) versus 12 weeks of iWD (n = 6) Mean atherosclerotic plaque size on en face aorta in the 2 groups of mice (n = 5 to 6 per group) Mean plaque area staining positively for MOMA2 (e) Representative photomicrographs of TUNEL staining (red) and CD68 staining (green) (scale bar = 10 μm) and quantification of the proportion of internalized apoptotic cells in plaques from the 2 groups of mice (n = 5 to 6 per group) Ldlr−/− male mice were put on 6 weeks iWD starting at 6 or 22 weeks of age (n = 11 and n = 9 mice Mean atherosclerotic plaque size in the 2 groups of mice Mean ± s.e.m.; two-tailed unpaired t-test (b Faecal samples collected at the end of week 8 (before treatment with antibiotics) and at the end of the experiment (after treatment with antibiotics) were analysed using 16S rRNA sequencing (n = 10 per group) (e-g) and proportional abundance of bacteria (g) demonstrate a great impact of the antibiotic treatment (ABx) on microbiome abundance and composition Plasma levels of total cholesterol at the end of the experiment (n = 10 per group) Ldlr−/−/Rag2−/− male mice were put on 6 weeks of cWD (n = 8) versus iWD (n = 7) Calculation of plasma cholesterol levels over the whole period of the experiment Mean ± s.e.m.; two-tailed unpaired t-test (h LDL receptor-deficient (Ldlr−/−) female mice were fed a Western-type diet (WD) for 3 weeks (w) either continuously (cWD) or intermittently (iWD) Mean atherosclerotic plaque size in the aortic sinus of the 2 groups of mice is shown (n = 5 cWD and n = 6 iWD) Cx3cr1creERT2/+ Rosa26LSL-Tomato Ldlr−/− mice on normal diet (ND) received tamoxifen treatment (TAM) to induce Tomato expression The mice were rested for 2 weeks on normal diet to allow for clearance of labelled blood monocytes The mice were then placed on 3 weeks of cWD versus 3 weeks of iWD Mice were killed at the end of the experiment for analysis of fate-mapped Tomato+ resident arterial macrophages (n = 15 cWD; n = 21 iWD) Representative photomicrographs showing staining for macrophages (CD45+ CD68+) to quantify the numbers of intimal MacAIR macrophages Total CD45+ CD68+ macrophage count in the aortic arch of the 2 groups of mice at the end of the experiment Percentage of Tomato+ CD45+ CD68+ macrophages in the intima (MacAIR) (among intimal CD45+ CD68+ macrophages) of the 2 groups of mice Number of Tomato+ CD45+ CD68+ intimal (MacAIR) macrophages Number of Tomato+ adventitial (adv.) macrophages After 5 weeks of recovery mice were put on cWD for 8 weeks to assess the role of myeloid-specific expression of SPIC on atherogenesis Mean atherosclerotic plaque size in the aortic sinus of the 2 groups of mice is shown Mean atherosclerotic plaque size in the en face aorta of the 2 groups of mice (n = 12 Lyz2Cre+/− Spicflox/flox and n = 10 Lyz2Cre+/− Spicflox/+) Mean plasma total cholesterol levels at the end of the experiment (n = 24 Lyz2Cre+/− Spicflox/flox and n = 25 Lyz2Cre+/− Spicflox/+) Ldlr−/− female mice were lethally irradiated and reconstituted with Lyz2Cre+/− Spicflox/flox bone marrow mice were put on 6 weeks of cWD (n = 9) or 6 weeks iWD (n = 7) Mean atherosclerotic plaque size in the aortic sinus of the 2 groups of mice Mean ± s.e.m.; two-tailed unpaired t-test (c-f) A heatmap of selected markers for each macrophage subtype (Res = Resident; MacAIR/Trem2; IFN/Inflam = interferon/inflammatory) derived from analysis of the mouse public data set on scRNASeq of atherosclerotic lesions in Ldlr−/− mice subjected to various durations of continuous high fat diet (HFD) Hierarchical clustering is shown based on log2FoldChange Barplot for three macrophage subtype proportions for each duration of continuous HFD Representative values of plasma cholesterol levels at the indicated time points NRP1 is represented in the most enriched biological pathways Quantification of the percentage of macrophages (M0 in e and M1 in f) with internalized apoptotic cells; two separate experiments with n = 3 biological replicates/group Supplementary Methods and Supplementary Data Description of the methods for diagnostics assessments of the Bayesian relevant life-course exposure models Download citation DOI: https://doi.org/10.1038/s41586-024-07993-x Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Signal Transduction and Targeted Therapy (2024) Sign up for the Nature Briefing newsletter — what matters in science and Vancouver Whitecaps’ Tate Johnson battle for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps’ Ralph Priso (13) challenge for the ball during the second half of an MLS soccer match Saturday Vancouver Whitecaps’ Sebastian Berhalter (16) and St Louis City’s Cedric Teuchert collide while battling for the ball during the second half of an MLS soccer match Saturday Vancouver Whitecaps’ Tristan Blackmon (33) passes around St Louis City’s Marcel Hartel during the second half of an MLS soccer match Saturday Vancouver Whitecaps’ Édier Ocampo yells after being injured during the second half of an MLS soccer match against St Louis City’s Conrad Wallem (6) and Vancouver Whitecaps’ Édier Ocampo (18) battle for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps’ Emmanuel Sabbi battle for the ball as St Louis City’s Conrad Wallem (6) watches during the first half of an MLS soccer match Saturday  Ahmed came close to getting the first goal of the night just past the half-hour mark  The second half began with both teams searching for the difference  Substitute Daniel Ríos came close to getting that long-awaited first goal The ‘Caps kept pounding at the door in the latter stages of the match The Magazine of the Science Fiction and Fantasy Field Takaoka’s Travels, Tatsuhiko Shibusawa (Stone Bridge/Monkey 979-8-98868-870-9, $18.95, 178pp, tp) May 2024 a Bud­dhist monk who also went by the monastic name Shinyo set forth from Canton with three aides to Hindustan (India) reportedly mauled and eaten by a tiger somewhere near the Malay peninsula art critic and French translator Shibusawa Tatsuo (who wrote under the pen name Tatsuhiko Shibusawa) began drafting Takaoka Shinnō Kōkai-ki an episodic novel about Prince Takaoka’s fated journey to India Shibusawa’s fanciful novel won the Yomiuri Prize in 1987 Shibusawa never received the prize; like the Prince It says something about the publishing industry that it’s taken thirty-seven years for this colourful book to be published in English under the title Takaoka’s Travels we can thank the publisher Monkey and the always peerless work of translator David Boyd There’s scant information online about Prince Takaoka or his journey to Hindustan The one reference to the Prince on Wikipedia relates to the “Kusuko Incident,” a brief internecine struggle between Emperor Saga and ex-Emperor Heizei (Takaoka’s father) allegedly motivated by Heizei’s lover Fujiwara no Kusuko while not prepared to write “an exhaustive biography of the Prince’s life,” thankfully spends the early part of the novel contextualising his protagonist inspired the young Prince to visit Hindustan Everything in Hindustan is the op­posite of what it is in the world we know Our day is their night; our summer is their winter and mountains sink deep into the earth like massive holes It’s only in his sixties that Takaoka obtains per­mission to leave Japan for Hindustan an enslaved boy seeking shelter from his master the expedition encoun­ters wonders they “could never have imagined in Japan,” starting with a hat-wearing dugong that Akimaru trains to speak man-shaped anteater on the shores of Vietnam That confrontation displays Shibusawa’s cheeky with Engaku and the anteater having a Douglas Adams-esque ex­change about whether the anteater’s existence is an anachronism as the species won’t be discovered for at least six centuries The Prince’s pilgrimage gets weirder from there leading to its inevitable historical conclusion (but with a touching twist) David Boyd provides biographical details about Shibusawa (like Prince Takaoka Shibusawa and his publisher were charged with obscenity for a two-volume translation of the Marquis de Sade’s novel L’Histoire de Juliette ou les Prospérités du vice he took “Sade’s work into his own hands… making the obscene work even more obscene in translation.” The case made Shibusawa a literary and counterculture star in Japan not just because he was dismissive of obscenity laws but because he exuded an anti-establishment ethos with his sunglasses and pipe Shibusawa’s provocative French translations also extended to artists like Jean Cocteau (the avant-garde) and J.K sensibilities which are threaded through Takaoka’s Travels Takaoka would regularly touch Kusuko’s breast while she cupped “his tes­ticles rolling them around like a pair of Baoding balls.” And in one astonishing scene Shibusawa encapsulates Cocteau’s surrealism and Huysman’s hedonism a starv­ing Baku has been dropping foul-smelling dung “The Hindu Kingdom” beseeches the Prince to sleep in their gardens hoping the Baku will feast on Takaoka’s dreams leading to a moment where the Governor’s daughter – the spitting image of Kusuko – masturbates and fel­lates the now satiated Baku but it’s a genuine showstopper: provoca­tive All of it is cleverly juxtaposed against the Prince’s asceticism (whatever his desires Takaoka’s Travels is overflowing with scenes like this record a “lifelong obsession with all things strange and exotic.” While it’s a tragedy that Shibusawa died at the peak of his powers I can only hope that interest in this won­derfully strange novel will lead to translations of his other novel-length works This review and more like it in the May 2024 issue of Locus. While you are here please take a moment to support Locus with a one-time or recurring donation We rely on reader donations to keep the magazine and site going and would like to keep the site paywall free but WE NEED YOUR FINANCIAL SUPPORT to continue quality coverage of the science fiction and fantasy field Copyrighted material may not be republished without permission of LSFF Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" “I once did a four book deal at a Locus party on the publisher’s back deck It connects me to the publishing world.” Locus Magazine and Website cover science fiction and allows us to continue to share our content without a paywall Even a small contribution goes a long way toward keeping Locus going and keeping you up to date with new exciting books and in the know about the SFF world Sign in Join now, it's FREE! © 2025 BVM Sports. Best Version Media, LLC. with goalkeeper Yohei Takaoka making two crucial saves This match marks Vancouver’s fourth consecutive game without a loss having conceded only one goal during this streak extended its winless run to five matches but managed to halt a four-game losing streak The Whitecaps put forth a strong offensive effort coming close to scoring multiple times but ultimately were unable to find the net the inability to score raises questions about the Whitecaps' finishing ability against less formidable opponents yet fell short in converting their chances Vancouver will face Inter Miami CF in the first leg of their CONCACAF Champions Cup semifinal on Thursday which will be a critical match for momentum and morale as they seek to capitalize on their recent form The Whitecaps need to sharpen their finishing as they move forward especially with upcoming high-stakes matches in the CONCACAF Champions Cup where capitalizing on scoring opportunities will be essential for success The summary of the linked article was generated with the assistance of artificial intelligence technology from OpenAI We use cookies to ensure that we give you the best experience on our website If you continue to use this site we will assume that you are happy with it OK Privacy policy and Vancouver Whitecaps' Emmanuel Sabbi battle for the ball as St Louis City's Conrad Wallem (6) watches during the first half of an MLS soccer match Saturday Louis City's Conrad Wallem (6) and Vancouver Whitecaps' Édier Ocampo (18) battle for the ball during the second half of an MLS soccer match Saturday Vancouver Whitecaps' Édier Ocampo yells after being injured during the second half of an MLS soccer match against St Vancouver Whitecaps' Tristan Blackmon (33) passes around St Louis City's Marcel Hartel during the second half of an MLS soccer match Saturday Vancouver Whitecaps' Sebastian Berhalter (16) and St Louis City's Cedric Teuchert collide while battling for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps' Ralph Priso (13) challenge for the ball during the second half of an MLS soccer match Saturday and Vancouver Whitecaps' Tate Johnson battle for the ball during the second half of an MLS soccer match Saturday Janelle Monáe embraced Black dandyism’s elegance at the Met Gala in an all-star collaboration with Oscar winner Paul Tazewell and designer Thom Browne completing her look with a sparkling ethical diamond brooch from 1800 Tequila for a finishing touch Known for turning heads with her gala looks and white pin-striped suit tailored to her frame with sharp She topped the suit with a black top hat and wore a small black-and-gold clock over her left eye She wore the tequila diamond brooch tucked beneath her outer jacket ultimately revealing it on her tie — a bold statement honoring her ancestors and dandy-dressing family members while celebrating a more conscious approach to fashion jewelry Monáe said the ensemble she revealed Monday honored her ancestors and dandy-dressing family members while celebrating a more conscious approach to fashion jewelry “It felt like the right statement to make in fashion,” the Grammy-nominated performer told The Associated Press in a recent interview before the gala She felt like she was back in art school to do a group project with Tazewell and Browne calling the collaboration “one of a kind.” becoming the first Black man to win best costume design “nobody else would,” and designed her 2023 Met Gala red carpet ensemble: an oversize half-black half-white tweed suit worn over a hoop skirt that earned rave reviews “Just having all three of our minds together around this theme it’s honestly the most exciting thing,” Monáe said “The experience of us creating this look together getting excited and dreaming up whatever we wanted to dream has been the best part of it all.” With Black dandyism carving its place in Met Gala history Monáe found sentimental value in wearing the 1800 Tequila ethical diamond but crafted from the brand’s Cristalino tequila with the brooch design inspired by the crystalline bottle “Knowing the impact that traditional diamond mining has had on African nations it felt important to me that this piece reflected a more conscious and considered approach to jewelry wearing,” said Monáe who is a part of the host committee alongside the likes of Simone Biles Monáe is one of the many cultural powerhouses leading Black dandyism into the fashion spotlight at the Met Gala as the Metropolitan Museum of Art unveils its new costume exhibit “Superfine: Tailoring Black Style.” It marks the Met’s first show centered exclusively on Black designers and the first in more than two decades to spotlight menswear It’s also a tribute to the rich legacy of dandyism a style that has long carved space for radical self-expression especially for those overlooked or misunderstood Monáe said she was in awe of the technology used to craft the diamond from tequila The tequila was aged for 16 months in both new American and French oak barrels before being finished in port wine casks for an additional six months “It gives a rare brilliance and shine,” she said and I feel like this should be the future of diamond making This combination of photos shows Janelle Monae's fashion outfits at The Metropolitan Museum of Art's Costume Institute benefit gala across several years Janelle Monae attends The Metropolitan Museum of Art's Costume Institute benefit gala celebrating the opening of the "Superfine: Tailoring Black Style" exhibition on Monday The 17-year-old forward will remain in Japan with his current side until he turns 18 in March and will officially join the club Takoaka has enjoyed a successful start to his fledgling career scoring regularly at club and international level as he most recently impressed at the 2023 Under-17 World Cup The youngster scored four times in the group stages as Japan matched their second-best finish in the tournament by reaching the round of 16 in Indonesia We look forward to welcoming Rento to the club when he officially joins in March 2025 feature videos and interactive content to get you closer to the action Open the Saints app today! Promising Southampton centre forward Rento Takaoka secured a valuable point for Japan's U20 team every Southampton fan would agree that the club has lost their momentum at a crucial time the February fixture list was kind for the Saints in all honesty Now, if you believe that the remaining month could yield some pleasing results, then you may become less optimistic watching the upcoming schedule. The reason being Southampton will welcome Brighton and then visit Chelsea and Liverpool in the next couple of weeks Hence, many Southampton fans could be excused for tuning in to see the youth team play rather than witnessing Southampton's humiliating defeats again. Luckily, the young Saints have surpassed expectations to progress further in the Youth Cup. On top of that, the Saints will smile further after knowing their teenage wonderkid's commendable performances. We are talking about Japan's emerging prospect Rento Takaoka who is turning heads with his Asian U20 Cup's displays Takaoka showed his remarkable finishing ability to avoid a defeat for his national team Attempting a well-taken goal while trailing behind shows that Takaoka has the composure needed to thrive in English football I know it's early to set huge expectations from the 17-year-old but we have seen many Southampton talents fulfilling their sky-high potential let's hope that the striker grows leaps and bounds to become an established Premier League starter in a few years let's wish the best to Takaoka and Japan for their Asian U20 Cup campaign © 2025 Minute Media - All Rights Reserved The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER ","https://fansided.com/",{"alt":"5r","src":"5s","url":"5t"},{"type":"5q","value":"5u"},"link","Minute Media","https://www.minutemedia.com/",{"text":"5x","url":"5y"},{"type":"5w","value":"5z"},"All Rights Reserved Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands the current Site Expert for Saints Marching has been a passionate Southampton fan for the past 12 years It's his deep love for the game that has helped some of his best football journalism pieces feature on platforms like OneFootball Whether breaking down the latest Saints transfer rumors or tactical shifts Mehdi hopes to bring insightful and engaging coverage to fans you’ll likely find him savoring a cup of coffee Now, if you believe that the remaining month could yield some pleasing results, then you may become less optimistic watching the upcoming schedule. The reason being Hence, many Southampton fans could be excused for tuning in to see the youth team play rather than witnessing Southampton's humiliating defeats again. Luckily, the young Saints have surpassed expectations to progress further in the Youth Cup. On top of that, the Saints will smile further after knowing their teenage wonderkid's commendable performances. We are talking about Japan's emerging prospect Rento Takaoka who is turning heads with his Asian U20 Cup's displays desires and delusional thoughts on a journey far west By There is no English-language author who could weave an authentic tale about a legendary Japanese prince’s journey to the West not the European west – the west of Hindustan No Japanese person ever had reached this place when the novel “Takaoka’s Travels” takes place Only through translation would it be possible to embark on a dreamy adventure through spacetime into the Orient at the height of the T’ang Dynasty (618-907 CE) Written by Tatsuhiko Shibusawa and first published in 1987 Takaoka’s Travels celebrated its English-language release in May 2024 a Japanese prince born at the dawn of the Heian Period (794-1185) art and court culture flourished in the capital of Kyoto Takaoka was disgraced from Kyoto after his father conspired against the emperor He grew up to become a Buddhist monk and later aspired to travel to India making him the first Japanese person to have traveled so far west The first recorded Japanese visit to India wouldn’t happen until the 16th century – 700 years later he still achieved something pretty darn impressive But this novel is anything but an accurate account of Prince Takaoka’s voyage dreams of fantasies and fantasies of dreams and startling visions of the fantastic and profound at every turn Such rashness and boldness were typical of Shibusawa (b who made his name by embracing the outrageous and obscene He first emerged on the literary scene as a translator of French literature most notably André Breton and Marquis de Sade he was convicted in Japanese courts for being too obscene in his translation of de Sade’s “Juliette”.) He wrote Takaoka’s Travels much later in life but the novel’s psychologically-tinged mysticism fits into his long career of essay-writing which often focused on the demonic and the erotic – two motifs that are ever-present on Takaoka’s journey Shibusawa carefully balances two contrasting poles: the travelog of an adventure through medieval Asia and a barrage of Freudian fantasy dream sequences each chapter follows a particular segment or incident as Takaoka moves further west and closer to India grounded in exotic but realistic cross-cultural encounters with history “The Dugong,” that means departing from the thriving port city of Guangzhou and encountering a young stowaway each chapter involves a concoction of magical realism dreams and fantasy that defy all logic and explanation–In Chapter One a series of talking fantastic beasts of past and future lore The fun of the work comes from this two-sided aspect I found myself captivated by the ornate kingdoms and curious customs of the various Southeast Asian lands Takaoka visits Shibusawa at times intentionally contradicts himself or even deliberately points out when the events of his tale are impossible or simply don’t make sense These postmodern devices can make the story feel dreamy to the point of flimsy at times There is an ugly complex lurking beneath the story Takaoka’s relationship as a boy with his father’s consort Freudian element is at the core of Takaoka’s motivation for his journey and makes it far from a classical Buddhist search for enlightenment Shibusawa clouds the pursuit of nirvana with subconscious sexual urges as many of the fantastic happenings are laced with sexuality and eroticism But Shibusawa does not so much as contrast these two worlds as demonstrate their intricate interconnection is also a journey across the crooked contours of one’s own psychology This boundless curiosity allows him to encounter feathered women and petrified men alike The more profound depths of this work reside in the clouded corners of his consciousness Shibusawa spotlights uncomfortable links between lust and travel These disturb the traditional narrative of the spiritual quest the classical journey that leads to self-discovery They also disrupt any kind of simple Freudian description of the uncanny as coming from aspects of the subconscious The worlds that Takaoka encounters are all their own as much as a reader might be tempted to see them as direct reflections of the prince’s repressed sexual urges An effective and confident translation by David Boyd captures Shibusawa’s playful tone with its grand echo of a classical journey laced with postmodern spunk A great success of the translation is the way it manages to introduce countless unfamiliar places objects and mythologies to an English reader without overexplaining I found myself sorely wanting a map to reference.) Takaoka’s Travels enables us to step into worlds we could scarcely imagine is much like Prince Takaoka’s – we face one completely unfamiliar sight after another We are left to either try to dissect and connect new wonders with our own lives or simply navel-gaze in wonder and ignorance From purple sweet potatoes to wild horse sightings, here’s how to make the most of Okinawa’s tropical escape Explore the best local brands shaping Tokyo’s fashion scene From vintage clothing to Hawaiian-themed goods, here’s what’s worth checking out before it’s gone From buying and registering a bike to key rules of the road Collagen staples for beauty and health in Japan Our handpicked list of the best events going on this month. Love, identity, and the untold tales of Japan’s queer community Everything you need to know before and during a natural disaster Stay up to date with Tokyo news and events "none"); */ } $("document").ready(function($) { let url = window.location.pathname; let nav_home = $('.only-home'); if (url != '/' && url != '/#') nav_home.removeClass("row"); }); $("document").ready(function($) { let url = window.location.pathname; let nav_home = $('.only-home'); let nav_home2 = $('.only-home2'); let nav = $('.without-home'); if (url != '') { $(window).bind('scroll load resize' airweave the leading manufacturer of premium bedding products  I founded Airweave in 2007 after taking over my uncle’s company It was a manufacturer of plastic injection molding machine for fishing lines using the resins to develop high-quality mattresses B.E in Applied Physics from Nagoya University (Japan) I have been the President & CEO of Nippon Kouatsu Electric Co.,Ltd I had also been the outside auditor of eAccess Ltd. an Internet service provider which is now merged to the Softbank Group and a director of various associations in Japan such as Chubu Economic Federation and Japan Stanford Association What have been the main lessons you have learned in your career and how do you implement them in your management The main lesson in my career is that I know nothing I doubt I can be successful in business without help from others who have different ideas and experiences – thus I strive for having diversity in the management team and staff members I have a couple of good old friends who I’d like to call my mentors It is a theme I apply to every aspect of my life industrial and financial news about global economies with a focus on understanding them from within BC – Vancouver Whitecaps FC announced on Wednesday that the club has exercised the 2025 Major League Soccer contract options on goalkeepers Isaac Boehmer and Yohei Takaoka The ’Caps currently have 22 players on their MLS roster for next year The club also confirmed it will not exercise the 2025 contract options for the following five players; however ongoing discussions continue with goalkeeper Joe Bendik The club is also continuing discussions with wingback Ryan Raposo who is out of contract at the end of the year “We are continuing our conversations with these six players about their situation and how they align with our plans for the future,” explained Axel Schuster “Even though we are not pursuing the existing options we will take the time provided to us by the MLS roster building opportunities.” the club declined the contract option on forward Levonte Johnson who will be eligible for the MLS Re-Entry Draft "We are thankful to Levonte for his two seasons at the club,” added Schuster “In our exit meeting both sides agreed that now is the right time to go in another direction and we wish him all the best.” For the latest information, visit whitecapsfc.com and follow @WhitecapsFC on social media who will be looking forward to welcoming him to the club at the end of the season Takaoka scored late on to rescue a late 2-2 draw for Japan against Syria on Monday morning adding to his assist from the opening game His 85th-minute equaliser ensured Japan maintained their unbeaten record at the competition as they look to qualify for the next stage of the tournament BC – Vancouver Whitecaps FC attacking midfielder Ryan Gauld and goalkeeper Yohei Takaoka have been named to the MLS Team of the Matchday following their performances in the club's 3-1 away victory over Minnesota United FC on Matchday 24 Gauld recorded three assists on the night for the first time in his Whitecaps FC career becoming the first 'Caps player to record three helpers in one game since Inbeom Hwang did on September 29 Gauld's performance marked the 16th time he's tallied multiple goal contributions in one game during his Whitecaps FC career the Scotsman has now recorded 16 goal contributions in his last 17 MLS appearances with 10 of those coming in the last eight matches Laborda scored the eventual gamewinner in the 17th minute as he headed in his second goal of the season to double the 'Caps early advantage The Uruguayan defender was also a key piece in keeping Minnesota out of the match This is the first time Laborda has been named to MLS' Team of the Matchday ¡Mathías Laborda nomá! 🇺🇾 pic.twitter.com/cp21u26Z1N Takaoka came up big for the Blue and White in the 30th minute as he denied Joseph Rosales' penalty kick attempt with a strong save to his right to keep Minnesota out of reach The save marked the second time Takaoka has made a penalty kick save in MLS regular season play with the first coming against Colorado Rapids in April 2023 BIG STOP ❌ @yohei_takaoka41#VWFC | #VANvMIN pic.twitter.com/COul0yOqkl The 'Caps continue their four-game road stretch with a Canadian clash against CF Montréal on Saturday The Blue and White return to BC Place for their '80s Match against Sporting Kansas City on Wednesday, July 17. Kickoff is set for 7:30 p.m. PT. Tickets are available at www.whitecapsfc.com/tickets Fort Wayne is at the forefront of proactive initiatives designed to make a lasting and meaningful impact Our community’s view of the world and having a global mindset were the focus of a recent Sister Cities International visit to Fort Wayne by several dignitaries from Takaoka Takaoka is Fort Wayne’s first sister city signed a joint declaration to commemorate the continuation of the sister cities partnership between Fort Wayne and Takaoka and the Takaoka Chamber of Commerce signed a partnership document as a sign of commitment to exploring additional economic development opportunities in the future This signing was a renewal of a document that was signed in 1994 by the Fort Wayne Chamber of Commerce (predecessor to Greater Fort Wayne Inc.) and the Takaoka Chamber of Commerce Fort Wayne is honored to be a sister city with Takaoka We’re so thankful for the sister cities partnership The focus on learning and citizen diplomacy is to be commended Fort Wayne and Takaoka share a commitment to making our cities and countries as places that give back and think of others We’re fortunate to be part of a global effort aimed at friendship and peace we envision future growth and success for our respective cities We also want to maintain and enhance the closeness of the sister cities program we’ll be able to accomplish so much and gain an even better appreciation for one another The next men’s World Cup takes place in 2026 and when it does Yohei Takaoka – Vancouver Whitecaps FC's offseason signing from J1 League champions Yokohama F Marinos who's emerged as one of the top goalkeepers in Major League Soccer this year – hopes to represent Japan in that World Cup And that dream is part of the journey that brought him to MLS the decision to pursue his World Cup dream in North America and the exciting challenge of trading clubs The 27-year-old first remembers playing soccer in the family garden in Yokohama That’s where he began to learn the game under the tutelage of his parents and alongside his brother Recalling those first touches in Japan brings a smile to his face: “I was young Takaoka reckons many kids in Japan did the same He’d play with them in the park and at school soccer is so popular in Japan that perhaps only baseball surpasses it According to the Whitecaps' shot-stopper – who joined the call fresh off a Canadian pitch where he’s preparing for Saturday's Matchday 11 showdown at home against Minnesota United FC (10:30 pm ET | MLS Season Pass) – that surge in popularity is due in part to the Samurai Blue “I think soccer is more popular now because of the [2022] World Cup," said Takaoka The success of that national team – and its generation of players spread across the globe working their way to the world’s top leagues – has inspired Takaoka as well helping fuel the decision to join Vancouver Reflecting on the performances of the Samurai Blue in Qatar – where they topped Group E after defeating powerhouses Germany and Spain before falling in penalties to Croatia in the Round of 16 – Takoka says he feels proud He emphasizes the respect he has for the team Despite not yet receiving a senior call-up the chance to one day play with them is now his main motivation not only Canada but in the United States: a lot of places to play away from home When Takaoka made the decision to leave Yokohama last year but one he felt was important to his career goals he left behind his childhood home and he left Yokohama F Marinos after just winning the championship with them collecting a J1 League Best XI accolade as their goalkeeper Marinos] I won the J1 League and I won the best 11 of J1 League," he recalled but the new challenge is specifically what he sought out: “It's not easy to go to different places Takaoka says he’s been able to handle those changes with confidence: “Everyone helps me a lot That's why I’m comfortable to play here with confidence Vancouver manager Vanni Sartini speaks Japanese a convenient factor in Takaoka’s transition Sometimes instructions for Yohei come from the gaffer in Japanese – during games or in team meetings “His Japanese is so good," Takaoka said of Sartini “[He speaks Japanese] in the meeting sometimes and everyone is like the Whitecaps manager says having Takaoka with the team helps him practice his Japanese He says even the team has picked up a few phrases learning from conversations between the keeper and gaffer “I speak Japanese with him almost every day and sometimes when I have to give instructions to him on the field," said Sartini "Even if I know that he understands English it's the same with the Spanish-speaking player I think it gives them the thing that we really care for them if we are making an effort to speak in their language.” The city of Vancouver is itself a help in the transition food and welcoming locals that Takaoka feels gratitude for: “The city is amazing and the water The transition is still fresh and while Takaoka adjusts to his new home in Canada he must also adapt to a new league and club Takaoka admits he's becoming more comfortable on the field and with his teammates but emphasized that he needs to stay focused 79’ | HUGE stop by Yohei Takaoka to keep us even!! Fighting for that clean sheet 😤 @yohei_takaoka41#VWFC 0-0 #Rapids96 Takaoka says that turning-point match against Montréal is the highlight of his experience so far “We got the first MLS league win against Montréal we celebrated and everyone came to me and said ‘You played well were cheering him on too: “The fans were so amazing Takaoka is proud of the form he’s found since then but adds emphasis on his focus: “I have to stay calm The season is long and there comes different times I have to be ready for that and I need consistency.” It’s still early days in the Major League Soccer tenure of the promising goalkeeper from Yokohama but he’s settled quickly and is focused on mastering the transition and representing his home nation one day but I think that's the barrier to being a champion," Takaoka said "So that's why I try to do my best every day And also I want to be selected by the Japan national team Today's print edition Home Delivery A lost prince of Japan is being given new life The historical Takaoka was a royal who lived during the Heian Period (794-1185) Following a failed power play by his father Takaoka’s family lost its influence and he became a Buddhist monk presumed dead somewhere near present-day Singapore.googletag.cmd.push(function() { googletag.display('div-gpt-ad-1499653692894-0'); }); In a time of both misinformation and too much information quality journalism is more crucial than ever.By subscribing Your subscription plan doesn't allow commenting. To learn more see our FAQ Sponsored contents planned and edited by JT Media Enterprise Division will establish a production line specifically for electric vehicles at its Takaoka plant in Toyota This will be Toyota’s first production line in Japan dedicated to EVs The line will have an estimated production capacity of 100,000 units per year The major automaker aims to strengthen its production capacity in anticipation of future growth in the EV market please disable the ad blocking feature and reload the page This website uses cookies to collect information about your visit for purposes such as showing you personalized ads and content By clicking “Accept all,” you will allow the use of these cookies Users accessing this site from EEA countries and UK are unable to view this site without your consent and one of which will be dedicated to EV production It will produce the bZ4X electric sport utility vehicle Toyota is not only considering expanding the variety of EV models produced at the plant but also intends to establish a battery assembly line there The model is currently being produced on the same line as hybrid vehicles at its Motomachi plant in the city but high manufacturing costs have been a challenge Toyota’s global sales of EVs in 2024 increased by about 30% year-on-year to 140,000 units Our weekly ePaper presents the most noteworthy recent topics in an exciting © 2025 The Japan News - by The Yomiuri Shimbun Prince Takaoka was a son of an emperor who later became a priest he set off on a journey to China and then beyond The ninth-century history underpins the fantasy Takaoka’s Travels a translation by David Boyd of twentieth-century writer Shibusawa Tatsuhiko’s Takaoka Shinnō kōkaiki Takaoka and his companions take a fantastic voyage visiting ancient kingdoms mainly in Southeast Asia who live out their last days eating nothing but honey and whose corpses are valued for their medicinal properties It was from Kusuko that he first heard of the strange land of Hindustan; she claimed to see him taking a ship there in the future she was at the heart of a power struggle that resulted in her suicide and saw Takaoka removed from his position as a presumptive future emperor Kusuko appears in Takaoka’s dreams and nightmares He is haunted by the image of her throwing a ball of light toward Hindustan—a stone or egg from which she says she will be reborn as a bird Twin characters called Akimaru and Harumaru shift between human and bird as well as female and male; they may be the same person So much of the novel takes place in dreams that it is difficult to say exactly what happens A chapter of implausible events may end with the reader learning that only Takaoka experienced them Shibusawa further disrupts reality through anachronism with characters talking about future travelers like Marco Polo while an anteater they meet disputes objections that its species cannot be found in Asia and will only later be “discovered” by Christopher Columbus while the reader can sense the research that has gone into bringing to life the historical background (and may feel compelled to look up numerous unfamiliar place names) Shibusawa is always ready to pull the rug away and show he is not bent on academic rigor he recreates the lost delights of exoticism where every new destination may be magically different in the telling Shibusawa was known as a literary critic and a translator and was found guilty in a notorious obscenity trial over a Marquis de Sade translation Takaoka’s Travels was his first full-length novel written shortly before his death; it posthumously won the Yomiuri Prize The novel has become a cult favorite and was later adapted into a manga by Kondō Yōko With its many references to little-known Japanese and Asian history this was surely not an easy book to translate I can imagine that there were many hard choices along the way to keep the English reader from getting lost while maintaining the spirit of the text ancient India is commonly referred to as Tenjiku in Japanese but Boyd opts for “Hindustan” to convey a similar effect but his decision to bring Takaoka’s Travels into English is key; perhaps it was spurred on by translations into Italian and French in recent years Just as Shibusawa shone a light on the obscure historical figure of Prince Takaoka by making him the protagonist of his 1987 novel Boyd’s translation brings that story of dream and drifting between strange lands to contemporary readers in English Translated by David Boyd from Takaoka Shinnō kōkaiki Published in May 2024 by Stone Bridge Press Banner image: The cover of Takaoka’s Travels We’re back with another AFTN Soccer Show and it’s our 2024 Christmas Special so jump on the Polar Express for a couple of hours of Festive Fun as we have football chat and a few surprise guests dropping in throughout the show to chat about a whole variety of things and ponder do you really need that item in the Boxing Day sales? Major League Soccer gave Whitecaps fans an early Christmas present as they released the 2025 schedule last week giving fans in Vancouver and throughout the league a chance to plan ahead early and perhaps book some trips with discounts in those very sales and at times disappointing set of fixtures for the ‘Caps Plus we chat a bit more about the ‘Caps seemingly completed search for a new coach and ponder is the MLS draft now redundant after it felt buried this year we sit down with Whitecaps goalkeepers Isaac Boehmer and Yohei Takaoka and midfielder Sebastian Berhalter to chat about what Christmas is like in their respective families and what they’re hoping to find under the tree this year All of this plus we have three Christmas hits from 1974 to round off our year of Whitecaps 50th anniversary celebrations look back at what Christmas was like in 1974 we play some fun games that you can join in on at home and Michael even gives you a potted version of the musical Oliver Here’s the rundown for the main segments from the episode: episodes of the podcast on the following services: Direct Download Apple podcasts iPhone App Spotify Google Podcasts iHeart Radio Podbean Stitcher Radio Network Our CiTR Radio Show Page and website in this browser for the next time I comment This site uses Akismet to reduce spam. Learn how your comment data is processed. AFTN is a soccer podcast and website that covers the beautiful game in Canada All donations welcome and appreciated at this tough time and will help us to continue to bring you the content you enjoy VANCOUVER — The Vancouver Whitecaps couldn't take advantage of some early chances then failed to score during a late frenzy and were forced to settle for a 0-0 draw against FC Dallas in a Major League Soccer match Saturday night Midfielders Mathias Laborda and Sebastian Berhalter both had great opportunities in the opening half but were stopped by Dallas goalkeeper Jimmy Maurer frustrating the crowd of 23,188 at BC Place Stadium Late in the match midfielder Deiber Caicedo looked to have a clear path to the net but a diving Maurer swept the ball off his feet In added time Caicedo had a shot blocked and Nicolas Fleuriau Chateau sent a ball wide The draw leaves the Whitecaps (12-8-6) sixth in the Western Conference with 42 points Vancouver is 5-1-2 in the last eight games The point left Dallas (9-12-7) 10th in the West and two points out of the ninth and final playoff spot in the conference Dallas has won just three times in 16 games at BC Place The Whitecaps played the game with a deleted roster including midfielder Ryan Gauld — the club’s second leading goal scorer with nine — have been called up for international duty Vancouver was also playing without forward Brian White who leads the team with 12 goals and 51 assists FC Dallas looked to have a good scoring chance early in the second half Attacker Jesus Ferreira sent a pass to Petar Musa behind the Vancouver defence Musa had lots of space but sent a harmless shot wide of the net After a slow start in the opening half the Whitecaps found their legs and put Dallas under pressure Vancouver had back-to-back scoring chances in the 24th minute First midfielder Alessandro Schopf found an open lane and fired a shot from the left side of the box that bounced off the far post Laborda corralled the rebound and took a shot from the right side that went wide In the 33rd minute Laborda directed a header that Mauer stopped A few minutes later Berhalter arched a free kick toward the corner of the net that was stopped by a diving Mauer Berhalter also had a bending shot from distance that forced Maurer to make a leaping Dallas had a great scoring chance in the final seconds of the first half Midfielder Paul Arriola headed a ball that went over the outstretched hand of Vancouver goalkeeper Yohei Takaoka and toward the open net Attacker Katlego Ntsabeleng desperately tried to reach the ball but it bounced past his left foot and wide of the net a Scottish international the Whitecaps signed earlier in the week made his Vancouver debut in the 84th minute … The Whitecaps play five of their remaining eight games at BC Place tying team records for wins and points with 24 … Dallas plays three of its final six games on the road the other Whitecaps called up for international duty were midfielders Ali Ahmed (Canada) Pedro Vite (Ecuador) and forward Fafa Picault (Haiti) … Dallas had a record of 3-2-0 when playing games not held on a Saturday The Whitecaps host the San Jose Earthquakes next Saturday at BC Place Stadium Dallas’s next MLS game is on the road against Real Salt Lake on Sept This report by The Canadian Press was first published Sept Designed for Harsh ClimatesLocated in the Hokuriku region in the north of Japan’s main island that is known for its harsh weather conditions, House in Takaoka was built on a deep lot in an old district of Takaoka, with a neighboring house and a warehouse abutting the property on the north and south side. Contacted by a couple with young daughters, UNEMORI ARCHITECTS was requested to build a bright and comfortable house with a closed courtyard. © Kai NakamuraBuilding the house elevated on stilts and without a foundation leaves an open space for further modifications offering a range of possibilities for the future You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email He will remain with Nissho Gakuen High School until he turns 18 in March 2025 A Saints spokesman confirmed: "We look forward to welcoming Rento to the club when he officially joins in March 2025."  Takaoka impressed Saints scouts at the U17 World Cup where he scored four goals as Japan reached the round of 16 in Indonesia The Hokuriku Shinkansen bullet train connects Tokyo with Toyama Ishikawa and (since March 2024) Fukui Prefecture This region along the Sea of Japan has its own distinctive history and culture Hokuriku was the hub for a vital trading route plied by sailing ships known as kitamaebune Besides carrying cargo from Hokkaido all the way to Osaka these vessels also stopped at ports along the way introducing a range of foods and culture from afar In the first of two episodes on the Hokuriku region Kyle Card visits Takaoka (Toyama Prefecture) and Kanazawa (Ishikawa Prefecture) to explore the traditional food culture that blossomed in the region thanks to the kitamaebune traders This impressive Buddhist temple in Takaoka was built to pray for Maeda Toshinaga An old house that was formerly the residence of a kitamaebune agent is now a museum displaying materials about the trading vessels Formerly an entertainment district for wealthy merchants this area of Kanazawa City boasts a well-preserved traditional townscape It is a designated Preservation District for Groups of Historic Buildings it takes about 2 hours 15 minutes by the Horikuku Shinkansen Vancouver Whitecaps are looking to sign goalkeeper Yohei Takaoka. Photo by Hiroki Watanabe/Getty ImagesThe Vancouver Whitecaps have made an offer for Yokohama F. Marinos goalkeeper Yohei Takaoka has spent parts of the last three seasons with Yokohama helping the club to the 2022 J1 League championship and earning a spot in the league's Best XI - Stream on ESPN+: LaLiga, Bundesliga, more (U.S.) Takaoka has made 86 league and cup appearances for Yokohama F. Marinos, but the player wants a new challenge. Takaoka is also aiming to work his way into the Japan national team He made his professional debut with Yokohama FC After becoming the team's regular keeper in 2017 he moved to the Japanese top-flight with Sagan Tosu in 2019 If a deal is completed, Takaoka will need to beat out incumbent Thomas Hasal who made 17 appearances last season for the Whitecaps who made 15 appearances in goal for the Caps didn't have his contract option picked up.