Rowe Price announced that Chris Tarui will be joining its institutional business as Business Development Executive Tarui will be responsible for helping to formulate and drive the firm’s business development efforts for alternative investments with institutional clients globally Rowe Price’s Global Distribution Executive Committee where he served as Executive Vice President He has more than 17 years of experience in the financial services industry and previously served as a director at KKR & Company and as a client advisor for Bridgewater Associates Tarui holds a Bachelor of Arts from Pepperdine University from the University of Southern California’s Marshall School of Business In his role as Business Development Executive Tarui will create a global distribution plan for alternative investments and lead the sales effort while identifying and cultivating new business prospects and partnering with distribution teams across sales Rowe Price has identified liquid and private alternatives as an area of strategic investment for the firm over the next two to three years “We are delighted to welcome Chris to T His deep experience and history of working with some of the largest and most sophisticated public and corporate pensions and consultants make him a meaningful addition to our team Chris’ new role speaks to our commitment to strengthening our alternatives business development capabilities and his strategic focus in this area will be instrumental in enabling us to stay at the forefront of serving the full range of our clients’ rapidly expanding needs.” © Copyright 2012 - 2023 | citybiz | All Rights Reserved Connecticut-based Bridgewater is the world's largest hedge fund Chris Tarui filed a complaint earlier this year with a Connecticut agency alleging the harassment and describing Bridgewater as a "cauldron of fear and intimidation" that kept him silent withdrew his claim earlier this week and did not receive any financial compensation from the firm Bridgewater also agreed to withdraw Tarui's employment restrictions Bridgewater employees are bound to noncompete agreements The supervisor who is alleged to have harassed Tarui is still employed at the hedge fund Still, the case has drawn scrutiny to Bridgewater's unique culture, which Dalio describes as radical transparency employee conversations can be recorded and viewed by other employees Bridgewater requires workers to agree to settle claims in private arbitration The public agency filing in Connecticut Reached by telephone, Tarui declined to comment. His LinkedIn page says that he started as a director at private-equity firm KKR this month 2016By David A.Grogan/CNBC/Getty Images.Save this storySaveSave this storySaveIt was May of 2014 and Christopher Tarui and his supervisor were sitting together on a hotel-room couch in Denver the world’s largest hedge fund run by one of the world’s most famed finance billionaires were on a business trip when Tarui claims his supervisor put his hand on the small of his back He alleges that the supervisor continued to pursue him for about a year claiming his supervisor told him he had an “itch to scratch” and asking if he would agree to a “sexual experience” with him who was put on paid leave two days before he filed his complaint said he was initially hesitant to report the incidents because he worried the firm’s tendency to videotape high-stakes meetings would make his allegations public within the firm and subsequently circulated among management It is not uncommon for the $154 billion firm to record meetings and later show them to employees as a sort of teaching tool New employees were treated to a recording that reportedly illustrated Bridgewater’s culture—an exchange between Dalio and a female manager who ended up in tears on the tape but the firm reportedly still takes surveillance so seriously that some employees have to lock up their personal cell phones every morning a “cauldron of fear and intimidation,” as Tarui called it in his complaint allegedly held an off-site retreat in 2012 at which employees got drunk and went skinny-dipping according to several former employees who spoke to the Times After several people in attendance complained one employee responsible for organizing the event was fired Tarui and Bridgewater both asked the Connecticut commission to withdraw the complaint The newspaper noted that Bridgewater employees are required to settle disputes in arbitration Hemphill is a medical journalist and editor. She received her BA in Journalism from Temple University and is a board-certified Editor in the Life Sciences, a fellow of the American Academy of Optometry and a member of the American Medical Writer’s Association. With a career in medical publishing that began in 1986, Hemphill is currently a Healio Senior Editorial Director, overseeing the optometry and ophthalmology content channels. She has received numerous publishing awards, the most notable of which was an American Society of Healthcare Publication Editors Bronze Award for Best Regular Department in 2018 for “PCON Reports” in Primary Care Optometry News. SAN FRANCISCO — Participation in a therapeutic mother-baby program resulted in significant symptom reduction of perinatal psychiatric conditions, Nicole Tarui, MD, told Healio at the American Psychiatric Association Annual Meeting. Results, which were reviewed quarterly and assessed by percent change from admission to discharge, showed a mean 60% decrease in EPDS scores following treatment. “Clinically speaking, that is a huge number,” noted Tarui, a reproductive psychiatrist and medical director of the Maternal Outreach Mood Services Program at El Camino Health in California. “What that means is, mom is able to return to baseline to take care of herself, take care of her baby and also take care of her family.” Tarui N, et al. Treatment of perinatal conditions in the Maternal Outreach Mood Services (MOMS) program: An analysis of EPDS scores in PHP/IOP levels of care. Presented at: American Psychiatric Association Annual Meeting; May 20-24, 2023; San Francisco. Get the latest news and education delivered to your inbox The email address associated with your Healio account is: If you would like to edit or change the email address that your subscriptions and alerts are sent to, use the "Update email address" link. Activity saved! You'll receive reminders to complete your saved activities from Healio CME. Glycogen storage disease V (GSDV, McArdle disease) and GSDVII (Tarui disease) are the most common of the rare disorders of glycogen metabolism. Both are associated with low lactate levels on exercise. Our aim was to find out whether lactate response associated with exercise testing could distinguish between these disorders. Two siblings with Tarui disease, two patients with McArdle disease and eight healthy controls were tested on spiroergometric exercise tests with follow-up of venous lactate and ammonia. A late increase of lactate about three times the basal level was seen 10–30 min after exercise in patients with Tarui disease being higher than in McArdle disease and lower than in the controls. Ammonia was increased in Tarui disease. Our results suggest that follow-up of lactate associated with exercise testing can be utilized in diagnostics to distinguish between different GSD diseases. Neuromuscular Disorders and Peripheral Neuropathies Volume 7 - 2016 | https://doi.org/10.3389/fneur.2016.00082 Introduction: Glycogen storage disease V (GSDV McArdle disease) and GSDVII (Tarui disease) are the most common of the rare disorders of glycogen metabolism Both are associated with low lactate levels on exercise Our aim was to find out whether lactate response associated with exercise testing could distinguish between these disorders two patients with McArdle disease and eight healthy controls were tested on spiroergometric exercise tests with follow-up of venous lactate and ammonia Results: A late increase of lactate about three times the basal level was seen 10–30 min after exercise in patients with Tarui disease being higher than in McArdle disease and lower than in the controls Discussion: Our results suggest that follow-up of lactate associated with exercise testing can be utilized in diagnostics to distinguish between different GSD diseases Tarui disease or glycogen storage disease VII (GSDVII) and McArdle disease (GSDV) are characterized by exercise intolerance, cramps and myoglobinuria or rhabdomyolysis, and very low lactate levels during exercise (1–5) reduced enzyme activity of muscle phosphofructokinase (PFKM) is detected resulting in impaired phosphorylation of fructose 6-phosphate to fructose 1,6-bisphosphate a more proximal defect in the glycolysis chain is present based on the defect of glycolytic enzyme myophosphorylase We studied the lactate and ammonia profiles in two siblings with Tarui disease associated with symptom-limited maximal spiroergometric exercise testing. For comparison, two patients with McArdle disease and eight controls were studied. In defects of muscle metabolism, the level of lactate and/or ammonia associated with exercise may be altered depending on the character and location of the metabolic defect in the energy chain (5, 6) We report here the differences found in exercise-induced metabolites in these different study groups Patient Tarui 1 was a 58-year-old otherwise healthy man without regular medication he began to experience strong attacks of muscle pain and vomiting during extensive physical activity associated with increased CK levels Mild muscle weakness was observed concentrating on hip flexors and extensors on both sides and ankle flexors and extensors on right side the 57-year-old younger sister of patient Tarui 1 had similar symptoms as her brother since the age of 10 aged 35 (McArdle 1) and 20 years (McArdle 2) were studied and muscle biopsy analysis showing non-lysosomal glycogen accumulations and a total lack of myophosphorylase staining were consistent with McArdle disease a homozygous mutation of PYGM gene was detected in both of them (c.2056G > A; p.G686R in McArdle 1 and c.1A > G in McArdle 2) For comparative analyses, eight healthy gender and age-matched control subjects were studied, the anthropometric characteristics are given in Table 1 The main results of spiroergometric exercise testing as well as the venous lactate and ammonia results associated with exercise testing in patients with Tarui disease (Tarui 1 and Tarui 2) patients with McArdle disease (McArdle 1 and 2) and the controls Informed consent was signed by the patients and controls and the study has been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments (The Medical Ethics Committee of Helsinki and Uusimaa Hospital District The lactate and ammonia specimens were taken into fluoride oxalate and EDTA syringes centrifuged and analyzed with a Cobas Integra 400 + analyzer (Roche Diagnostics and lactate and ammonia ions were assayed by enzymatic methods using lactate dehydrogenase and glutamate dehydrogenase The spiroergometric results are presented in Table 1 (A) The blood lactate levels associated with spiroergometric exercise testing in patients with Tarui disease and the results of two patients with McArdle disease are given as well as the mean values of eight healthy controls matched to the age and gender of the patients (B) The blood ammonia (NH4+) levels associated with spiroergometric exercise testing in patients with Tarui disease the results of two patients with McArdle disease are given as well as the mean values of eight control subjects matched to the age and gender of the patients The healthy controls had normal exercise performance and oxygen uptake (Table 1) and their RQ values at maximal exercise were clearly higher than 1 The lactate and ammonia values of the control subjects increased normally with a maximal increase of lactate and ammonia 2–6 min after exercise the utilization of glycogen during anaerobic exercise is interrupted by the lack of PFKM leading to very low levels of lactate during exercise in spiroergometric testing a late increase of lactate two to three times the basal value was seen at time points 10–30 min after exercise this study demonstrates for the first time that exercise lactate profile distinguishes Tarui disease from McArdle disease glycogen is metabolized via glucose 6-phosphate to fructose 6-phosphate but in Tarui disease fructose 1,6-bisphosphate cannot be produced a slight residual PFKM activity of 3–4% out of normal was found in enzyme activity analyses which might lead to a slight increase of lactate during exercise if the residual phosphofructokinase production would increase the lactate level the lactate raise should start during exercise with a maximum level of lactate 2–4 min after exercise and not at time points 10–30 min exercise as we here demonstrate second wind phenomenon was observed only in patient McArdle 2 it is not likely that the late increase of lactate in Tarui disease would be associated with second wind phenomenon Figure 2. Schematic presentation of the pathways of glycolysis modified from Ref. (18) The main points of the glycolysis chains involved in Tarui disease and McArdle disease are presented The black arrow indicates that glycolysis disrupted by Tarui disease can continue through pentose phosphate pathway (PPP) at glyceraldehyde-3 phosphate The dotted arrow: fructose 6-phosphate accumulates because of Tarui disease and its metabolism may continue in the PPP pathway from where it may enter in protein or nucleic acid synthesis Increase of synthesis of proteins or nucleotides means also increase of products of their metabolism Some enzyme names and products of the glycolysis chain have been left away to get the figure more feasible to the present purpose In some previous studies on Tarui disease, suggestions of a late lactate increase after exercise have been recorded, confirming our results (19, 20). In addition, findings that suggest increased glyceraldehyde-3 phosphate levels and alteration into the PPP route in Tarui disease during exercise have been published (3) We report here for the first time a full-length spiroergometry study with follow-up of lactate and ammonia as well as extended follow-up after exercise comparing the results also with healthy controls In McArdle disease, increased ammonia during exercise has previously been reported (4, 25–28), as also we found in patient McArdle 2. Compared to patient McArdle 2, patient McArdle 1 showed only slight increase of ammonia in exercise even though he reached maximal subjective level of 19/20. Earlier, Mineo et al. (19) have found corresponding slight ammonia responses in McArdle disease Heterogeneity of McArdle disease might be one explanation for the observed variances in ammonia level it is difficult to assess objectively the maximality of exercise in McArdle disease because the absent lactate response causes that ventilation is not stimulated normally during exercise we show that Tarui disease is associated with low lactate levels during exercise with a late increase of lactate after exercise and exceptionally high ammonia levels during and after exercise The particular lactate profile differentiates patients with Tarui disease from patients with McArdle disease and helps the clinician to choose proper genetic tests and it suggests that further study should be performed on exercise glucose metabolism in patients with rare glycogen storage disorders we recommend to utilize maximal bicycle spiroergometry with sufficiently long (30–40 min) follow-up of ammonia and lactate levels after exercise PP: spiroergometric testing of patients Tarui 2 and drafting of the article; MS: treatment of the patients with Tarui disease and drafting of the article; JP: clinical study and drafting of the article; TW: spiroergometric testing of patient Tarui 1 spirorgometric testing of the control subjects and drafting of the article; EY: genetic testing and manuscript drafting; SS: clinical study of patients with Tarui disease and drafting of the article; PH: spiroergometric testing of patient McArdle 2 spiroergometric testing of the control subjects and manuscript drafting; LU: the biochemical expert in the study drafting and critical revision of intellectual biochemical contents of the data; HT: genetic studies and data analysis and manuscript drafting; BU: clinical examinations and drafting of the article; MA: clinical examination of patients Tarui1 and patients McArdle 1 and 2 The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish The Crisil Coalition Greenwich 2024 Public Pension Defined Benefit Study sponsored by T Rowe Price confirmed our expectations that defined benefit (DB) plans became overweight risk assets and have maintained this positioning despite broadly higher capital market assumptions (CMAs) Our Solutions team analyzed the effects of historical CMAs and expected return on assets (EROAs) to understand how each could be impacting asset allocations now and how these allocations could evolve going forward Our analysis indicates that plans could be in a position to meet their EROAs while lowering overall portfolio risk Our mid-2024 Crisil Coalition Greenwich survey revealed that the average defined benefit plan had significant exposure to risk assets Figure 1 highlights that many respondents were overweight their own equity targets This finding was not surprising—over a decade of zero or near-zero interest rates hampering fixed income return potential contributed to this dynamic What was somewhat surprising given the notable increase in available yields in recent years is that many allocations have remained overweight risk assets and underweight public fixed income Figure 2 illustrates the period of near-zero interest rates that forced plans to increase equity allocations in an effort to achieve their targeted return goals The sharp increase in interest rates in recent years has reversed this dynamic yet many plans remain overweight equity and could consider reevaluating this positioning Central bank rate hikes of 2022–2023 have led to higher-yielding fixed income assets With our survey indicating that the majority of plans intended to hold EROAs steady we evaluated how impactful increased CMAs could be to asset allocation possibilities We simulated thousands of portfolio weights and constructed portfolios using 2020 and 2025 return assumptions to understand the impact that different return environments would have had on portfolios Source: Crisil Coalition Greenwich 2024 Public Pension Defined Benefit Study Figures inparentheses ( ) indicate number of respondents approximately 2% of all the potential portfolios would have achieved the average pension EROA of 7%1 when using 2020 CMAs This figure increases dramatically—to nearly 20% of all potential portfolios meeting the EROA target—when using 2025 CMAs that have risen as higher cash rates have increased fixed income yields across sectors We estimate that revised asset allocations that increase exposure to fixed income can potentially reduce overall portfolio risk by nearly 20% while still achieving an ex-ante return profile that aligns with typical public plan EROAs the average current allocation would generate an expected five-year return of 7% which is in the middle of the stated range we targeted the same return value while minimizing risk increased allocations to plus-sector fixed income (bank-loans distressed debt) would offset reductions in private equity The results of our public defined benefit plan survey confirm that plans remain overweight risk assets; however the current environment creates opportunities to reassess asset allocations as there are more portfolio construction options that can deliver against return targets while lowering overall risk Som Priestley is head of Multi-Asset Solutions North America and a portfolio manager in the Multi-Asset Division Consultant Relations with the Americas division of T the organization responsible for the firm's institutional business in North America his responsibilities include OCIO and global alternatives distribution Ryan Wagner is an institutional client service executive in the Americas division 1 The 7% EROA target was informed by historic pension plan EROAs Source: Center for Retirement Research at Boston College National Association of State Retirement Administrators and Government Finance Officers Association Source for Bloomberg index data: “Bloomberg®” the Bloomberg Indices are service marks of Bloomberg Finance L.P including Bloomberg Index Services Limited (“BISL”) the administrator of the index (collectively “Bloomberg”) and have been licensed for use for certain purposes by T Bloomberg does not guarantee the timeliness or completeness of any data or information relating to these materials Source for Credit Suisse index data: : © 2025 CREDIT SUISSE GROUP AG and/or its affiliates Source for FTSE/Russell index data: London Stock Exchange Group plc and its group undertakings (collectively All rights in the FTSE Russell indexes or data vest in the relevant LSE Group company which owns the index or the data Neither LSE Group nor its licensors accept any liability for any errors or omissions in the indexes or data and no party may rely on any indexes or data contained in this communication No further distribution of data from the LSE Group is permitted without the relevant LSE Group company’s express written consent sponsor or endorse the content of this communication Source for HFR index data: All data and content on the HFR website and in the HFR Database products are for your informational and personal use only The total return data provided on the HFR website and the reports generated from them are for internal comprehensive enough or approved for use in connection with investment products or instruments or make the data available to a third party or otherwise use it for any commercial or public purpose unless you have a separate written agreement with HFR You require a written license from HFR to use the HFR data HFR marks and names and/or HFR Index names including but not limited to use in connection with investment products and instruments (regardless of whether such products or instruments are based on the name of investment products and instruments marketing and other materials publicly or commercially disseminated Please contact HFR for additional information at: INDICES@HFR.COM index data: Information has been obtained from sources believed to be reliable but J.P Morgan does not warrant its completeness or accuracy Source for Morningstar data and index data: © 2025 Morningstar The information contained herein: (1) is proprietary to Morningstar and/or its content providers; 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Additional information regarding the firm's policies and procedures for calculating and reporting performance results is available upon request.  Hawaiʻi representative Amy Perruso got her start in climate advocacy as a college student in California going door-to-door to talk to community members about pollution she says she sees that same sort of energy for climate action in young people today “There's this element of idealism that is only coming from the younger generation,” said Perruso “And it's that note that we really need to listen for and kind of align ourselves with.” Perruso is one of the lawmakers who will participate in the student-organized Climate Future Forum this Saturday at the Hawaiʻi State Capitol She’s no stranger to the political interests of young people — she taught high school social studies for decades before she became a representative “I've worked with young people my whole life “The moment of COVID was a break in what I saw working with young people in politics a sophomore at ʻIolani School and one of the organizers of Saturday’s Climate Future Forum knows that firsthand she turned to activism to fight feelings of powerlessness during the pandemic “The pandemic… was a moment of realization for me,” said Lin just forces you to change your entire lifestyle and change the way that you communicate with people reaching out to outlets where we can make a difference is really important.” Fellow ʻIolani sophomore and organizer Chisato Tarui is looking forward to digging into the nitty-gritty of climate policy with lawmakers during the forum But she understands that might not be every student's idea of a laid-back Saturday “We're going to have legislators there in the workshops and that may be intimidating for a lot of young people I know I would be intimidated by that,” said Tarui The workshops will be student-led so that newcomers feel welcome in the conversation Tarui and Lin along with other organizers will take the lead in introducing concepts like carbon pricing and intersectional justice to their peers “Having a young person teach something to another person of youth I think that in itself is going to be an incredibly accessible way to reach out to them,” said Tarui Lin hopes the forum will encourage young people to participate in the legislative process She remembers how nervous she was the first time she met with a lawmaker “And I walked in…and I was greeted with a person,” said Lin “And I think that made me realize that these people who are and the only thing that we need to do to make our voices heard is just to talk to them.” Tarui also hopes more students start to recognize they are an important political force we're still like 16 years old… but we still very much have a voice,” said Tarui Perruso would like to see this effort go a step further. She’s been an advocate for the Vote16 movement, which would lower the voting age to 16-years-old, opening up the democratic process to students like Tarui and Lin. “We've created a situation that has made it necessary for them to be fully participating citizens at an earlier age,” said Perruso. “So we have the responsibility, I think, to grant them that actual power.” Background: A deficiency of muscle phosphofructokinase (PFKM) causes a rare metabolic muscle disease, the Tarui disease (Glycogen storage disease type VII, GSD VII) characterized by exercise intolerance with myalgia due to an inability to use glucose as an energy resource. No medical treatment for GSD VII currently exists. The aim of this study was to determine whether a dietary intervention with excessive fat intake would benefit GSD VII. Results: During the 5 years on KD, the patient's muscle symptoms had alleviated and exercise tolerance had improved. In exercise testing, venous ammonia had normalized, the lactate profile remained similar, but oxygen uptake and mechanical efficiency had increased and parameters showing ventilation had improved. Conclusions: This study is the first to show a long-term effect of KD in GSD VII with an alleviation of muscle symptoms, beneficial effects on breathing, and improvement in exercise performance and oxygen uptake. Based on these findings, KD can be recommended under medical and nutritional supervision for selected patients with GSD VII, although further research of this rare disease is warranted. Volume 11 - 2020 | https://doi.org/10.3389/fneur.2020.00057 This article is part of the Research TopicStrategies to Fight Exercise Intolerance in Neuromuscular DisordersView all 11 articles Background: A deficiency of muscle phosphofructokinase (PFKM) causes a rare metabolic muscle disease the Tarui disease (Glycogen storage disease type VII GSD VII) characterized by exercise intolerance with myalgia due to an inability to use glucose as an energy resource No medical treatment for GSD VII currently exists The aim of this study was to determine whether a dietary intervention with excessive fat intake would benefit GSD VII Patient and Methods: A ketogenic diet (KD) intervention implemented as a modified Atkins diet was established for one patient with PFKM deficiency with a low late lactate response and very high ammonia levels associated with exercise We recorded the KD intervention for a total of 5 years with clinical and physiotherapeutic evaluations and regular laboratory parameters including breath gas analysis and venous lactate and ammonia measurements 8 months and 5 years after initiation of KD the patient's muscle symptoms had alleviated and exercise tolerance had improved but oxygen uptake and mechanical efficiency had increased and parameters showing ventilation had improved Conclusions: This study is the first to show a long-term effect of KD in GSD VII with an alleviation of muscle symptoms and improvement in exercise performance and oxygen uptake KD can be recommended under medical and nutritional supervision for selected patients with GSD VII although further research of this rare disease is warranted The patient is a 59 years-old man carrying a homozygous PFKM gene mutation, c.329G>A. The histological and genetic findings (9) and the analyses of the exercise lactate profile (10) have been published earlier he had normal motor development and normal exercise tolerability As a young boy he could run up to 100 meters but around the age of 12 years he started to develop symptoms He was never hospitalized due to the muscle symptoms or due to raise in creatine kinase (CK) values At age 59, there was mild muscle weakness in hip flexors and extensors and ankle flexors and extensors on the right side [MRC scale 4 out of 5 (11)] Medication for high blood pressure had been recently introduced (amlodipin 5 mg and valsartan 160 mg once a day) The patient's weight was 71 kg and height 177 cm (BMI 23.0 kg/m2) He could walk with a slow pace about 10 km but walking on an incline was limited by muscle pain because of muscle cramping and feeling unwell He did regular hunting and hiking trips in the forest He annually spent 4–5 days in Lapland with a group of friends hiking 15–20 km daily but he was always the last in the group and other members had to wait for him Ethical approval for the study was granted by the Medical Ethics Committee of Helsinki University Central Hospital Informed consent was provided by the patient and the controls The patient's diet was evaluated using a 3 days food record prior to KD initiation, and the evaluation was repeated 6 months after starting KD. Dietary intakes were calculated using the national food composition database of the National Institute for Health and Welfare, Finland (12) The KD was guided by the same dietitian (M.S.) throughout the study period Nutrition and diet were assessed and counseled at clinic visits or by phone or email contacts several times during the initiation period and later at least yearly Daily energy intake was planned to be at the same level as before the KD the amount of carbohydrates was restricted to 10 g per day and the consumption of fat and protein was encouraged aiming at a ketogenic ratio of ~1:1 Consumption of unsaturated fats was recommended to avoid unfavorable changes in serum lipids and calcium supplementations were introduced Temporal mitigation of carbohydrate restriction (using small or moderate amounts of e.g. rye bread) was allowed during the treatment when disadvantage of the diet was considered (strong increase of LDL-cholesterol) Laboratory parameters were followed up regularly; e.g., β-hydroxybutyrate, glucose, cholesterol, CK, and liver function were measured almost monthly during the first year and, after stabilization of the diet, twice during the second year and once a year thereafter, except for cholesterol values, which were measured more often. The laboratory results from the time points of exercise testing are presented in Table 1 concentrations of some vitamins (vitamins D and A) and urine calcium and creatinine were measured discretionarily to optimize nutrient intakes Blood β-hydroxybutyrate was also measured by the patient at home to ensure ketosis (target level 2.5–5) at the beginning every morning and evening Laboratory parameters before ketogenic diet (KD) and during the 5 years follow-up at the time points of cardiopulmonary exercise testing Younger men and women from the original controls were excluded Spearman's correlation test was performed between the baseline and diet phases for the patient as well as for the controls the calculated total energy intake was 2,660 kcal per day and consisted of 177 g of available carbohydrates (27 E% 107 g of protein (16 E%) and 164 g of fats (55 E%) the calculated total energy intake was ~2,880 kcal per day and consisted of 229 g of fats (72 E%) 189 g of protein (26 E%) and 12 g of available carbohydrates (2 E%) Vitamin D concentration (serum 25-hydroxyvitamin D3 and D2) was at the beginning of dietary therapy below reference values Already after 6 months' exposure to KD the patient began to experience a subjective alleviation of muscle symptoms manifesting as more rapid recovery and less muscle discomfort He was able to increase daily exercise and could gradually spend extended periods of time hiking and hunting in the forest his muscle strength (MRC) was within the normal range (5 of 5) except for ankle extension forces (4 of 5) Deep tendon reflexes were present excluding Achilles He felt that exercise tolerance had improved during KD and experienced less cramping and nausea during exercise than before KD He could now walk longer without stopping and could ski 10–15 km/day at the same speed as his friends During KD he could participate in long hiking trips He felt that especially capability to walk on an incline was better than before KD The patient's weight had decreased from 71 to 58 kg (height 177 cm) with BMI falling from 22.7 to 18.5 kg/m2 in 5 years The main results of the cardiorespiratory exercise testing during the follow-up at the time points of 3, 8 months and 5 years are presented in Table 2 The maximal working capacity was moderately reduced before KD but it remained lower than the values of age-matched controls The maximal oxygen uptake by body weight had a mild increase during KD and the mechanical efficiency (Wmax/VO2max) increased from 13.1 to 16.5% (normal value ≥20%) Results of cardiorespiratory exercise testing of the patient before and during KD During KD a decrease occurred in the very high maximal breathing frequency in exercise from 68 to 46/min and an increase in tidal volume from 44.6 to 60.3% of predicted value as assessed in slightly increased minute ventilation vs CO2 production (VE/VCO2) and O2 consumption (VE/VO2) and also in slightly decreased FetCO2 Figure 1. Lactate levels associated with exercise tests of the patient before diet and during the follow-up. The values of the control subjects without dietary intervention are also given for comparison. The baseline lactate data has been published earlier (10) the controls matched to the age and gender of the patient were obtained from the forementioned publication A strong correlation existed between the patient's baseline lactate values and his diet curves at 3 Figure 2. Ammonia levels associated with exercise tests of the patient before the diet and during the follow-up. Values of the control subjects without dietary intervention are also given for comparison. The baseline ammonia data has been published earlier (10) and the controls matched to the age and gender of the patient were obtained from the aforementioned publication No correlations existed between the baseline curve of the patient and those of the controls or the diet curves of the patient Figure 3. pH levels associated with exercise tests of the patient before the diet and during the follow-up. Values of the control subjects without dietary intervention are also given for comparison. The baseline ammonia curve has been published earlier (10) A high negative correlation existed between the patient's baseline curve and mean diet curve (rho = −0.826 During the 5 years follow-up of KD the patient remained clinically stable with subjective alleviation of muscle pain symptoms and better exercise tolerance working capacity and mechanical efficiency had increased lactate levels had decreased from the low pre-KD levels and the very high ammonia levels associated with exercise testing detected in the measurements before KD had decreased to normal KD had a beneficial impact also on respiratory parameters during exercise reflected as lowering of breathing frequency and the ventilatory equivalent for O2 (V′E/O2) and as increasing tidal volume the end tidal CO2 level (FetCO2) remained rather low indicating permanent hyperventilation tendency possibly attenuating our findings on the beneficial effects of KD The patient's original diet was evaluated for the first time before the initiation of KD KD was fairly well-tolerated by the patient high LDL-cholesterol level was measured (4.9 mmol/L) Since cardiovascular disease exists among the patient's immediate family the disadvantage of the KD for the patient was reconsidered and the restriction of carbohydrates was mitigated (e.g. Based on the patient's subjective experience of lowered exercise capability after the increase of carbohydrates With rising LDL-cholesterol values (up to 6.2 mmol/L) cholesterol-lowering medication was started after 3 years of KD The LDL-cholesterol level was at the 5 years control lower than before KD (2.1 vs no abnormalities were detected in the liver or kidney functions The patient's weight decreased by 13 kg during KD although it was not the original aim of the treatment the reported energy intake during KD was greater than before KD This may be due to the better working capacity leading to increased physical activity during the diet it is also possible that the difference between these calculated intakes is explained by normal day-to-day variation in food intake since the food record periods were short (3 days) Just before the exercise test at 8 months the patient returned to ketosis, and in the exercise test, a new increase in ammonia was detected. This suggests that even a short period of more carbohydrates may increase the ammonia level during the exercise test (Figure 2) highlighting the importance of carbohydrates in the high ammonia levels associated with Tarui disease Since convincing evidence between higher whole-grain consumption, which is a substantial contributor to carbohydrate intake, and lower risk of coronary heart disease, type 2 diabetes, colorectal cancer and all-cause mortality, is growing (29) extreme restriction of carbohydrates has to be well-founded The risk factors of chronic diseases must be considered during long-term KD as was done in our case with cholesterol-lowering medication started due to the increase in LDL-cholesterol levels The patient felt that his exercise capability was decreased in conjunction with increased carbohydrate intake and wanted to continue the strict KD with subsequent initiation of cholesterol medication During KD associated with the exercise test pH and base excess values remained rather high indicating that no metabolic acidosis had developed Carbohydrate intake restriction and ingested fat and proteins produce acidic ketones which have a tendency to advance to metabolic acidosis; however This is probably explained that there still would have been release of alkaline ammonia from protein catabolism The main strength of this study is that KD was carefully implemented and followed in a very cooperative patient Laboratory examinations were performed continuously the follow-up intervals increasing as the patient achieved a balance with KD Also the cardiorespiratory exercise testing was first performed with shorter intervals and the last test at 5 years to obtain data on long-term KD treatment A study limitation is that we had only one patient KD intervention in our patient with Tarui disease seemed to have a beneficial effect as measured by the patient's subjective condition with diminished muscle symptoms and increases in exercise capacity and oxygen uptake which also had a favorable effect on the patient's ventilation but with statin medication the levels were kept under control Our results thus encourage the implementation of KD in patients with Tarui disease as the risk factors of chronic diseases are considered The datasets for this article are not publicly available because of legislation The studies involving human participants were reviewed and approved by Medical Ethics Committee of Helsinki and Uusimaa The patients/participants provided their written informed consent to participate in this study MA: treatment of the patient with Tarui disease for statistical consultation and Carol Ann Pelli Common mutations in the phosphofructokinase-M gene in Ashkenazi Jewish patients with glycogenesis VII – and their population frequency Functional expression of human mutant phosphofructokinase in yeast: genetic defects in French Canadian and Swiss patients with phosphofructokinase deficiency during exercise in patients with McArdle disease Glucose-induced exertional fatigue in muscle phophofructokinase deficiency Metabolic myopathies: a practical approach No spontaneous second wind in muscle phosphofructokinase deficiency Aerobic conditioning: an effective therapy in MdArdle's disease Excess purine degradation in exercising muscles of patients with glycogen storage disease types V and VII PFKM gene defect and glycogen storage disease GSDVII with misleading enzyme histochemistry Unique exercise lactate profile in muscle phosphofructokinase deficiency (Tarui disease); difference compared with McArdle disease 12. Helldán A, Raulio S, Kosola M, Tapanainen H, Ovaskainen ML, Virtanen S. The National Findiet 2012 Survey. National Institute for Health and Wealthware; The National FINDIET 2012 Survey (2013). Available online at: https://www.julkari.fi/bitstream/handle/10024/110839/URN_ISBN_978-952-245-951-0.pdf?sequence=1 Google Scholar Increased ventilatory response to exercise in symptomatic and asymptomatic LMNA mutation carriers: a follow-up study An update on diagnosis and therapy of metabolic myopathies Skeletal muscle metabolism in duchenne and becker muscular dystrophy—implications for therapies New therapeutic approaches for Pompe disease: enzyme replacement therapy and beyond PubMed Abstract | Google Scholar Treatment of glycogenosis type V with ketogenic diet Infantile phosphofructokinase deficiency with arthrogryposis: clinical benefit of a ketogenic diet Work capacity of the Czechoslovakian population The human metabolic response to chronic ketosis without caloric restriction: preservation of submaximal exercise capability with reduced carbohydrate oxidation Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man Blood metabolite data in response to maximal exercise in healthy subjects Exercise-induced hyperammonemia: peripheral and central effects Muscle ammonia and amino acid metabolism during dynamic exercise in man CrossRef Full Text | Google Scholar Metabolism of branched-chain amino acids and ammonia during exercise: clues from McArdle's disease Carbohydrate metabolism during vertebrate appendage regeneration: what is its role Uptake and utilization of nucleosides for energy repletion Carbohydrate quality and human health: a series of systematic reviews and meta-analyeses Auranen M and Piirilä PL (2020) Beneficial Effects of Ketogenic Diet on Phosphofructokinase Deficiency (Glycogen Storage Disease Type VII) Received: 18 October 2019; Accepted: 15 January 2020; Published: 04 February 2020 Copyright © 2020 Similä, Auranen and Piirilä. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Päivi Liisa Piirilä, cGFpdmkucGlpcmlsYUBodXMuZmk= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. 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Membrane Physiology and Membrane Biophysics Volume 4 - 2013 | https://doi.org/10.3389/fphys.2013.00393 This article is part of the Research TopicRegulation of red cell life-span, erythropoiesis, senescence and clearanceView all 13 articles Phosphofructokinase deficiency is a very rare autosomal recessive disorder which belongs to group of rare inborn errors of metabolism called glycogen storage disease Here we report on a new mutation in the phosphofructokinase (PFK) gene PFKM identified in a 65-years-old woman who suffered from lifelong intermittent muscle weakness and painful spasms of random occurrence After ruling out the most common causes of chronic haemolytic anemia the study of a panel of 24 enzyme activities showed a markedly decreased PFK activity in red blood cells (RBCs) from the patient DNA sequence analysis of the PFKM gene subsequently revealed a novel homozygous mutation: c.926A>G; p.Asp309Gly This mutation is predicted to severely affect enzyme catalysis thereby accounting for the observed enzyme deficiency This case represents a prime example of classical PFK deficiency and is the first reported case of this very rare red blood cell disorder in Spain Phosphofructokinase (ATP: D- fructose-6-phosphate-1-phosphotransferase; EC 2.7.1.11; PFK) is a key regulatory enzyme of the glycolytic cycle and catalyses the conversion of fructose-6-phosphate to fructose-1,6-diphosphate (Figure 1). Human PFK is composed of three isoenzymes, muscle (M), liver (L), and platelet (P) (Vora, 1983; Nakajima et al., 2002) The P type is also known as Fibroblast type (F) Mammalian PFK is a tetrameric enzyme that is subjected to allosteric regulation Tissue isozymes randomly aggregate to form homotetramers or heterotetramers depending on the relative abundance of the subunits in a particular tissue PFK-M is the sole subunit in muscle cells whereas red blood cells (RBCs) contain both L and M subunits and form their hybrids (M4 Figure 1. Embden Meyerhof Pathway of RBC metabolism. Phosphofructokinase (PFK) catalyzes the transformation of fructose 6-phosphate into fructose 1,6 diphosphate. [Reproduced with permission from Van Wijk and van Solinge (2005)] Phosphofructokinase deficiency (OMIM 171 850) is a very rare autosomal recessive condition with heterogeneous clinical symptoms, mainly characterized by myopathy and/or haemolysis (Hirano and Di Mauro, 1999) Myopathy is caused by the accumulation of glycogen in muscle tissue due to the metabolic defect and is also known as glycogenosis type VII or Tarui disease The observed clinical symptoms reflect lack of muscle PFK activity and partial reduction of enzymatic activity in erythrocytes The latter usually is associated with mild haemolysis Up to now, only about 100 patients with PFK deficiency have been reported worldwide and 22 PFK-deficient PFKM alleles have been characterized. The gene encoding the M subunit (PFKM) has been assigned to chromosome 12q13.3 and spans 30 kb. It contains 24 exons and at least 3 promoter regions (Elson et al., 1990; Yamada et al., 2004) Among the detected mutations are mostly missense mutations and splicing defects We now describe here a Spanish patient with a clinical history of anemia who was found to be homozygous for a novel mutation in the PFKM gene (c.926A>G) This mutation encodes the substitution of aspartic acid by glycine at residue 309 (p.Asp309Gly) This is the first description of PFK deficiency in Spain A 65-years-old woman with long standing hypertension and type 2 diabetes was referred to our Unit because of intolerance to exercise and chronic fatigue From youth she suffered from spasms of random occurrence associated with muscle weakness especially after exercise due to myoglobinuria Physical examination showed no weakness or muscle atrophy and only a moderate splenomegaly without hepatomegaly or lymphadenopathy Parents were unavailable for study and there was no known consanguinity was present in a non-smoker brother whereas the three patient's daughters were normal Patient's clinical condition has remained stable in follow-up Red blood cell enzyme activity measurements The complete lack of PFK activity in muscle was confirmed on both histological preparations and muscle extracts Muscle abnormality was also confirmed by electromyography (EMG) that showed mild myopathic changes and by the forearm test characterized by a plane lactate curve with normal increase of ammonium a painful spasm occurred at the end of the forearm test Muscle biopsy showed slight amounts of polysaccharide (PAS) not digested by diastase and abnormalities in NADH-TR reaction We therefore postulate that decreased binding of the allosteric activator ADP will inhibit PFK enzymatic activity These findings support the physiological importance of Asp390 for the recently identified ADP binding site 3D crystal structure of PFK subunit from rabbit skeletal muscle and 3D model of normal/mutated PFKM (PDB 3O8L—protein databank) (A) Allosteric nucleotide (ADP) binding site residues (purple) in the center of the rabbit subunit of PFKM and the allosteric activator ADP are shown (atom coloring: carbon—green (B) Close-up of the c.Asp309Gly mutation in PFKM Asp309 is in close proximity of the ADP binding site Asp309 does not directly interact with ADP substitution of Asp309 by glycine is likely to disrupt multiple hydrogen bonds with Gly177 and the change of polarity and electrostatic interactions upon mutation of Asp309 will likely affect correct positioning of the side-chains of amino acids directly involved in ADP binding; in particular neighboring residue Phe308 which makes stacking interaction with the adenine ring of ADP The missense mutation is thus predicted to lead to a less functional PFK-M subunit the complete lack of PFK activity in muscle was confirmed on both histological preparations and muscle extracts The muscle abnormality was also confirmed by electromyography partial red blood cell PFK deficiency was reflected by the moderately decreased enzymatic activity in red blood cells haemolysis is a result of partial erythrocyte PFK deficiency the genetic defect involves the M isoform of PFK enzyme resulting a severe enzyme deficiency in muscle Erythrocytes that normally have two homotetramers (M4 and L4) and three hybrid isozymes (M3L lack the M4 isoform and the hybrid isozymes resulting in about 50% of normal PFK activity Despite PFK deficiency is a very rare autosomal recessive disease; its true incidence may be higher due to lack of recognition because the mild clinical presentation led her to be diagnosed until the consideration of dark urines ultimately led to the study of chronic haemolysis In our case the combination of RBC enzyme activity measurements and muscle biopsy analysis allowed for the correct diagnosis even at this late stage of life no specific treatment or cure of enzyme deficiency exists Although diet therapy may be highly effective at reducing clinical manifestations the condition does not progress to severe disability Because the liver and kidneys express only the L isoform The here described homozygous patient is the first Spanish case described to be affected by this very rare disease The identification of a novel homozygous missense mutation further extends the repertoire of PFK deficiency-associated mutations in PFKM This study has been partially supported by a Research Grant of the Spanish Ministry of Health (FIS Ref PI10/01460) We are indebted to the European Network for Rare and Congenital Anaemias (ENERCA) that has facilitated the connection and information exchange between the centers participating in this study Pavla Koralkova is supported by the grants NT11208 (Ministry of Health Czech Republic) and LF_2013_010 (Internal Grant Agency of Palacky University) A method and server for predicting damaging missense mutations Pubmed Abstract | Pubmed Full Text | CrossRef Full Text The crystal structures of eukaryoticphosphofructokinases from baker's yeast and rabbit skeletal muscle Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Altered allosteric regulation of muscle 6-phosphofructokinase causes tarui disease Pubmed Abstract | Pubmed Full Text | CrossRef Full Text The structure of the human liver-type phosphofructokinase gene Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Other erythrocyte enzyme deficiencies associated with non-haematological symptoms: phosphoglycerate kinase and phosphofructokinase deficiency Pubmed Abstract | Pubmed Full Text | CrossRef Full Text “Metabolic myopathies,” in Motor Disorders Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Mutations in muscle phosphofructokinase gene Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Phosphofructokinase deficiency in skeletal muscle: a new type of glycogenosis Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Tarui disease and distal glycogenoses: clinical and genetic update Pubmed Abstract | Pubmed Full Text The energy-less red blood cell is lost: erythrocyte enzyme abnormalities of glycolysis Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Isozymes of human phosphofructokinase: biochemical and genetic aspects Pubmed Abstract | Pubmed Full Text Novel testis- and embryo-specific isoforms of the phosphofructokinase-1 muscle type gene Pubmed Abstract | Pubmed Full Text | CrossRef Full Text Mañú Pereira MdM and Van Wijk R (2013) First description of phosphofructokinase deficiency in spain: identification of a novel homozygous missense mutation in the PFKM gene Received: 02 November 2013; Accepted: 13 December 2013; Published online: 30 December 2013 Copyright © 2013 Vives-Corrons, Koralkova, Grau, Mañú Pereira and Van Wijk. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) provided the original author(s) or licensor are credited and that the original publication in this journal is cited *Correspondence: Joan-Lluis Vives-Corrons, Red Cell Pathology Unit, Biomedical Dianostic Centre, University Hospital Clínic de Barcelona, c/ Villarroel 170, 08036-Barcelona, Spain e-mail:amx2aXZlc0BjbGluaWMudWIuZXM= Please enable JS and disable any ad blocker Climate change has recently been receiving significant and nervous attention from around the world Some countries and regions have adopted carbon pricing such as carbon taxes and emissions trading as countermeasures against global warming there is a concern about cross-border carbon leakage when a country introduces carbon pricing Even if carbon emissions decrease in that country as a result of carbon pricing carbon leakage increases carbon emissions abroad and in some cases even increases global emissions Cross-border carbon leakage undermines a country’s attempt to deal with climate change The literature has identified the following three main channels of carbon leakage International trade and foreign direct investment (FDI) exert an important influence on the channels explained above many studies that analyse the effects of emission regulations from a global perspective incorporate international trade and FDI most of those studies do not consider international transport Those that address the interaction between trade and the environment assume that the freight rates are exogenously given without an explicit model of the transport sector (e.g the amount of carbon emissions created by international transportation itself is too large to ignore According to the International Maritime Organisation international transport emitted approximately 920 million tonnes of CO2 in 2018 surpassing Germany's national emissions (the sixth-highest emission in the world) did not set specific targets for emissions from international transportation leaders of several countries and industry associations delivered a series of statements regarding global warming countermeasures related to international transport: we theoretically analyse the effect of unilateral carbon pricing on carbon emissions from production and international transport by explicitly modelling the international transport sector Our model is based on the endogenous transport cost literature which has found that the international transport sector is highly concentrated with transport firms having market power (Hummels et al The transport firms charge asymmetric freight rates on shipping in different directions on the same trade route subject to the backhaul problem The backhaul problem arises when the transport firm's shipping capacity is not utilised at the maximum level on the backhaul because of asymmetry in trade volumes endogenous determination of international transport volumes and prices explains a new mechanism of cross-border and cross-sector carbon leakage Figure 1 Top 10 deep-sea container shipping lines ranked by deployed capacity and market share Source: UNCTAD Review of Marine Transport 2020 Figure 2 Inter-regional contract freight rates The effectiveness of carbon pricing depends on the presence or absence of a backhaul problem If the exports from country A to country B (the fronthaul) exceed those from country B to country A (the backhaul) The equilibrium freight rate on exports from B to A is then independent of the marginal costs of shipping (Ishikawa and Tarui 2018) even though carbon pricing in shipping raises the effective marginal costs of shipping it affects the freight rates in an asymmetric manner when the backhaul problem is present carbon pricing on the transport sector reduces the fronthaul but affects neither the backhaul nor the associated emissions We show that unilateral carbon pricing on goods consumption is effective carbon pricing on goods production results in ‘positive’ cross-border carbon leakage: country A's carbon pricing on production lowers the fronthaul but increases the production in country B and the backhaul and hence generates positive cross-border carbon leakage but the endogenous increase in the freight rate mitigates them meaning the behaviour of transport firms weakens cross-border carbon leakage we find that both cross-border and cross-sector carbon leakage caused by carbon pricing can be ‘negative’ carbon pricing can be exceptionally effective because carbon pricing on a sector in a trading country may reduce emissions not only from the target sector but also from other sectors including those in other trading countries carbon pricing on shipping increases freight rates for both directions leading to the decrease in both fronthaul and backhaul emissions not only from the transport firm but also from the manufacturing firms can decrease implying that negative ‘cross-sector’ carbon leakage can occur This observation identifies a new source of carbon leakage due to endogenous transport costs We also show that if the backhaul problem is absent any carbon pricing is effective because the global greenhouse gas emissions necessarily decrease Our analysis also indicates that carbon pricing on international transport may not reduce overall trade-related emissions once we consider the interplay between endogenous transport costs and manufacturers' decisions on FDI Faced with a manufacturer that may engage in horizontal FDI (i.e the carrier may deter it strategically because the demand for transport decreases if horizontal FDI does not induce any trade in intermediate inputs it prefers FDI with a single foreign plant to FDI with two plants (a domestic and foreign plant) because there is no demand for international transport with two-plant FDI the carrier has an incentive to induce single-plant FDI These strategic moves by the carrier also affect the global emissions These findings follow from our theoretical framework which addresses the interlinkage between trade and environment by considering the transport sector explicitly They indicate another benefit of comprehensive regulation of emissions from both production (or consumption) and transport We argue that it is important to understand the market environment of the international transport sector when designing carbon pricing the backhaul problem impairs not only the efficiency of transportation but also the effectiveness of carbon pricing The effectiveness of carbon pricing will increase if policies can be taken to eliminate the backhaul problem at the same time as carbon pricing Editors’ note: The main research on which this column is based first appeared as a Discussion Paper of the Research Institute of Economy “Incomplete international cooperation to reduce CO2 emissions: Alternative policies” Journal of Environmental Economics and Management 24(3): 258-271 “Free trade and global warming: A trade theory view of the Kyoto protocol” Journal of Environmental Economics and Management 49(2): 205-234 “Unilateral CO2 reductions and carbon leakage: The consequences of international trade in oil and basic materials” Journal of Environmental Economics and Management 25(2): 162-176 Higashida, K, J Ishikawa and N Tarui (2021), “Carrying Carbon? Negative and Positive Carbon Leakage with International Transport,” RIETI Discussion Paper Series 21-E-102 “The triple inefficiency of uncoordinated environmental policies” Scandinavian Journal of Economics 107(1): 157-173 “The trade reducing effects of market power in international shipping," Journal of Development Economics 89: 84-97 “Environmental product standards in north-south trade” Review of Development Economics 15(3): 458-473 “Greenhouse-gas emission controls and international carbon leakage through trade liberalization” “Greenhouse-gas emission controls and firm locations in north--south trade” Environmental and Resource Economics 67(4): 637-660 “Backfiring with backhaul problems: Trade and industrial policies with endogenous transport costs," Journal of International Economics 111: 81-98 “Strategic environmental policies in the presence of foreign direct investment” Environmental and Resource Economics 30(1): 1-21 “Strategic emission tax-quota non-equivalence under international carbon leakage” International Economic Policies in a Globalized World “Environmental management policy under international carbon leakage” International Economic Review 54(3): 1057-1083 “Environmental policy when market structure and plant locations are endogenous” Journal of Environmental Economics and Management 24(1): 69-86 “Competition in regional environmental policies when plant locations are endogenous” “Pollution havens and industrial agglomeration” Journal of Environmental Economics and Management 58(2): 141-153 Licca-chan is known as “Japan’s Barbie,” and her appeal is spreading to all ages with adults turning the doll into a social media superstar One fan posts wry videos of the plastic poppet to more than 1 million Instagram followers while others painstakingly craft miniature clothes and share photographs of their fashion shoots a 34-year-old homemaker who once had ambitions of becoming a fashion designer said that her “dream has come true at one-sixth of the size” thanks to Licca-chan “If I see a stylish woman wearing something that I couldn’t wear because of my age or body size Licca-chan can still wear it and look good,” said Murayama who owns about 40 dolls and has made more than 1,000 outfits for them Licca-chan has been a favorite of Japanese children since she appeared in toy shops in 1967 and manufacturer Takara Tomy has sold more than 60 million of them The company’s official biography casts her as an 11-year-old girl with a Japanese designer mother and a French musician father she is smaller and less glamorous than Barbie who Murayama describes as “a supermodel” compared with Licca-chan’s more “familiar” look Murayama spends hours making clothes for her dolls and favors denim which her husband helps her bleach and tear to achieve the “distressed” look using tiny props to decorate mini cafes and fashion studios “There are lots of different jobs I would like to do such as running a cafe or a bakery or being a fashion designer,” she said there’s no way I could do them all in real life Murayama is a fan of a popular social media channel whose name translates as “Licca-chan’s Real Life.” It features tongue-in-cheek videos and photographs of the doll in mundane situations such as struggling with an overstuffed rubbish bag or relaxing at home in pyjamas The channel offers an antidote to the idealized lives that people project online who has more than 1 million Instagram followers but prefers to remain anonymous so that her videos do not get her into trouble at work “The Licca-chan in Licca-chan’s Real Life doesn’t live a glamorous life — she lives a real life in a messy room “If you show people that even someone like Licca-chan lives like that it gives them the courage to be comfortable with themselves.” Takara Tomy is not keen on Licca-chan’s Real Life saying the videos have “a different worldview” from their fiercely protected official image of the doll but the channel has struck a chord with Licca-chan’s adult fans who have formed an online community and swap homemade garments and accessories played with Licca-chan as a child and revived her interest about two years ago as a way to relieve stress She thinks the lingering effects of the COVID-19 pandemic have given people more time to spend at home with their hobbies and less chances to leave the house you have far fewer opportunities to buy new clothes,” she said adding that many people have “satisfied that desire by dressing up dolls instead.” Baba often recreates outfits from her own wardrobe for her dozens of dolls to wear Takara Tomy is aware of its growing adult fan base and has launched a “stylish doll collection” aimed at older customers Maruyama said “there are lots of adults who play with kids’ toys” in Japan where “there’s not really a separation” between the two who describes Licca-chan as a “national icon,” believes the doll’s appeal will only grow “Recently I’ve seen a lot of comments from people saying they didn’t know that this world existed,” she said one of the world's largest and most successful hedge funds is well-known for the cultural quirks instilled by founder Ray Dalio who insists on "extreme openness" and "radical transparency" in a 100-page manifesto titled Principles An employee who accused the firm of mishandling his harassment complaint describes the atmosphere very differently "The company's culture is nothing more than a cauldron of fear and intimidation achieved by constant surveillance -- audio and visual recording of every employee interaction and security guards patrolling both office floors," the employee says in an affidavit obtained by The Street which was filed with Connecticut's Commission on Human Rights and Opportunities in January The claims were first reported by the New York Times Bridgewater Client Advisor Christopher Tarui described a pattern of sexual harassment from a male supervisor and said a meeting he had with a human resources staffer regarding his concerns was taped and "widely shared" among co-workers.  Tarui, 34, joined Bridgewater in 2011, moving from California with his wife and young family for the job. His first sign of trouble at the hedge fund came two years later on a 2013 business trip with the supervisor who was also a married man with young children Tarui said he went to a strip club with the manager and watched as the manager had "sexual intercourse with a stripper." The supervisor later told Tarui ("preposterously," Tarui notes) that he felt "taken advantage" of by the exotic dancer the two Bridgewater employees were on a business trip in Denver Sitting together on a couch in a hotel room Tarui said that the team leader "caressed the small of my back," which "made me feel extremely uncomfortable." Tarui departed the room hastily saying he needed to sleep but said that his colleague was undeterred and sent a text message urging him to come back the two men were staying at a Boston hotel when the supervisor "brazenly explained" that he had "an itch to scratch," asking his married coworker if he ever "thought about being with other men," and going on to specifically request the two men share "a sexual experience," Tarui said replying that he was "not wired that way," and "did not want to be with a man," but noting that he made "no judgment" regarding his college's desires Fearing personal humiliation and anxious about his future with Bridgewater Tarui said he kept the matter to himself until last summer when his "worst fears" came true and the supervisor rated his performance poorly and began to suggest other career options "I realized I could no longer keep silent about what was happening to me," Tarui said and described the alleged harassment in a meeting that acknowledges that there are "some times when privacy is required," but recommends taping nearly all meetings and sharing them with all relevant people An outside spokesperson did not respond to request for comment but the company in an e-mailed statement to the New York Times said "we are confident our handling of this claim is consistent with our stated principles and the law .. We look forward to operating through a legal process that brings the truth to light." though many employment contracts require closed arbitration Tarui's complaint was withdrawn from the Connecticut employment oversight agency in March after a request he and Bridgewater filed jointly Matters came to a head for Tarui in December when he said he declined a senior manager's request to describe his "personal journey" at Bridgewater in connection with an upcoming "Quality Day" meeting "A majority of 'Quality Day' is devoted to subjecting junior employees to rapid-fire questions regarding a wide range of investment and socio-cultural topics as well as questions about Principles in front of approximately 200 of their colleagues," according to Tarui Another senior manager confronted Tarui that evening on the sidewalk outside the New York Public Library in Manhattan ""Nothing happened to you," Tarui claims the manager told him "You are blowing this whole thing out of proportion." two days before filing the complaint with the state Tarui was placed on paid leave from Bridgewater and escorted out of its offices in Westport Want TheStreet’s best daily stock and investing news right in your inbox every weekday Sign up today for our free newsletter and you'll receive an exclusive report explaining hedge fund guru Doug Kass' winning investment style Metrics details Metabolic myopathies are muscle disorders caused by a biochemical defect of the skeletal muscle energy system resulting in exercise intolerance The primary aim of this research was to evaluate the oxygen cost (∆V’O2/∆Work-Rate) during incremental exercise in patients with metabolic myopathies as compared with patients with non-metabolic myalgia and healthy subjects The study groups consisted of eight patients with muscle glycogenoses (one Tarui and seven McArdle diseases) seven patients with a complete and twenty-two patients with a partial myoadenylate deaminase (MAD) deficiency in muscle biopsy five patients with a respiratory chain deficiency seventy-three patients with exercise intolerance and normal muscle biopsy (non-metabolic myalgia) The subjects underwent a cardiopulmonary exercise test (CPX Medgraphics) performed on a bicycle ergometer Pulmonary V’O2 was measured breath-by-breath throughout the incremental test The ∆V’O2/∆Work-Rate slope for exercise was determined by linear regression analysis Lower oxygen consumption (peak percent of predicted one-way ANOVA) was seen in patients with glycogenoses (62.8 ± 10.2%) and respiratory chain defects (70.8 ± 23.3%) compared to patients with non-metabolic myalgia (100.0 ± 15.9%) and control subjects (106.4 ± 23.5%) ∆V’O2/∆Work-Rate slope (mLO2.min−1.W−1) was increased in patients with MAD absent (12.6 ± 1.5) and patients with non-metabolic myalgia (11.3 ± 1.3) compared with control subjects (10.2 ± 0.7; p < 0.001 patients with metabolic myopathies display an increased oxygen cost during exercise and therefore can perform less work for a given VO2 consumption during daily life-submaximal exercises little is known about oxygen cost of exercise in myoadenylate deaminase (MAD) deficiency case-control studies have been mostly employed by selecting patients with a given diagnosis of metabolic myopathy but for whom exercise intolerance may not be the chief complaint This shortcoming is prevented by consecutive inclusion of patients consulting for exercise intolerance and exercise-induced myalgia The primary aim of this research was therefore to evaluate the oxygen cost during incremental exercise in different metabolic myopathies compared with patients with non-metabolic myalgia and healthy subjects using a standardized methodology in a prospective-unselected cohort Table 2 summarizes the baseline characteristics and the results of exercise testing for the five subgroups of patients and the Control group Age and BMI were similar among groups (p = 0.598 and 0.265 One-way ANOVA showed a main effect of group for exercise duration [F(5,137) = 2.94; p = 0.015] but Games-Howell post-hoc tests did not identify significant differences between groups was significantly different between the six subgroups [F(5,137) = 17.61; p < 0.001 Post-hoc pairwise comparisons from the Scheffé test revealed that % Predicted maximal power was significantly lower in Glycogenoses compared with healthy controls (p < 0.001) % Predicted maximal power was significantly reduced in RCD group compared with Controls (p < 0.001) the average peak oxygen consumption achieved was 20.1 ± 7.8 mLO2.min−1.kg−1 representing 62.8 ± 10.2% of the age-predicted value The latter result was less than for Controls (p < 0.001) and Non-metabolic myalgia (p = 0.007) Scheffé post-hoc test revealed a significant lower percentage of predicted peak V’O2 achieved compared to Controls (p < 0.007) and Non-metabolic myalgia (p = 0.036) Oxygen cost of exercise in metabolic myopathies Data were analyzed using a one-way ANOVA with post hoc Games-Howell test for intergroup analysis *Significantly different from Control (p < 0.04) % Predicted maximal heart rate (HRmax) was significantly lower in MAD Absent group compared with Control (p = 0.005) and Non-metabolic myalgia (p = 0.007) groups peak O2 pulse was significantly decreased compared with Control (p = 0.005) and Non-metabolic myalgia (p < 0.001) groups The metabolic-chronotropic relationship (MCR) in the MAD Absent group (0.58 ± 0.18) was significantly lower than in the Control (p = 0.01) the MCR of Glycogenoses (1.50 ± 0.29) was significantly higher than the MCRs of all other groups The respiratory exchange ratio (RER) was similar between groups at rest and was found to be significantly less in Glycogenoses at peak exercise (0.91 ± 0.03) compared with all other groups (p < 0.02) Control group demonstrated a significantly higher RER at peak exercise (1.27 ± 0.06) than other groups (p < 0.04) with the exception of RCD group (1.25 ± 0.12 Peak V’E/V’O2 and V’E/V’CO2 slope were not significantly different between groups (p = 0.075 and 0.059 Post-hoc tests for oxygen uptake efficiency slope (OUES) and peak V’E/V’CO2 revealed no significant difference between groups Lactate concentration at rest was significantly lower in Glycogenoses (0.8 ± 0.3 mM) compared with Control (p = 0.01) lactate was significantly lower in Glycogenoses (0.9 ± 0.3 mM) compared with all other groups with the exception of MAD Absent (3.1 ± 1.6 mM Patients with absence of MAD activity showed lower lactate concentration at peak exercise compared with Control (p = 0.011) and Non-metabolic myalgia (p = 0.016) groups was significantly higher in Glycogenoses (112.5 ± 50.5 µM) compared with all other groups (p < 0.05) with exercise testing performed and reported in a standardized fashion The present prospective methodology permits comparison both across different metabolic myopathies and with non-metabolic myalgia during incremental exercise Visual inspection of the plots in Fig. 2 reveals two distinct profiles in patients A first group of metabolic myopathies that includes MAD absent and mitochondrial myopathy exhibits a large increase in ∆V’O2/∆WR slope (12.4–14.2 mLO2.min−1.W−1 A second profile includes MAD decreased and non-metabolic myalgia with moderate increase in mean ∆V’O2/∆WR slope due to substantial overlap in ∆V’O2/∆WR slope values between groups post-hoc tests failed to detect statistical differences between subgroups of patients Reasons for the disparity in ∆V’O2/∆Work-Rate slope in RCDs among studies deserve further investigation The increased work by respiratory muscles in patients with glycogenoses and RCD requires higher oxygen consumption to maintain this activity and may contribute to increase the ∆V’O2/∆Work-Rate slope due to the lower ATP produced/oxygen consumed ratio when lipid is the substrate Due to the prospective design of our study a single –standardized- incremental exercise protocol involving a 2-min warm-up was used in all subjects the extent to which the ‘second-wind’ mechanism contribute to the increased MCR and the greater ∆V’O2/∆Work-Rate slope in glycogenoses remains unknown Although the reduction of peak oxygen consumption is moderate in MAD Absent patients their greater ∆V’O2/∆Work-Rate slope may reduce exercise tolerance by increasing perceived effort Patients with metabolic myopathies exhibit a greater oxygen cost of exercise The clinical implication of this exacerbated oxygen cost of power production is that a patient with metabolic myopathy can perform less work for a given VO2 consumption during daily life-submaximal exercises This loss of efficiency could partially explain difficulties to maintain exercise in metabolic myopathies owing to increased perceived effort Written informed consent was obtained from each participant All procedures conformed to the standards set by the Declaration of Helsinki and the protocol was approved by the institutional ethics committee of Brest Medical University Hospital (Clinical Trial NCT02362685) Myoadenylate deaminase staining was absent in seven patients and decreased in twenty-two subjects Respiratory chain deficiency (RCD) group (n = 5) consisted of two patients with MELAS syndrome (m.3243 A > G MTTL1 gene mutations) and three patients with characteristic abnormalities of mitochondrial cytopathy (ragged-red and COX-negative fibers) and decreased complex IV activity in muscle biopsy specimen were recruited as a disease-control group (non-metabolic myalgia) referred for fitness for work evaluation in our department during the study period Data from the 1st minute of loaded exercise were discarded from analysis owing to the initial –exponential- delay of VO2 increase at the onset of work All statistical analyses were conducted two-tailed with α set at 0.05 and were computed using SPSS (V.25; IBM SPSS Statistics Assessment of data normality was determined by Shapiro–Wilk test Between-group differences were assessed using One-way ANOVA followed by Scheffe’ post hoc 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Muscle Nerve 35, 510–520, https://doi.org/10.1002/mus.20708 (2007) Predicted values for clinical exercise testing Accuracy of a pretest questionnaire in exercise test protocol selection Oxygen uptake efficiency slope: A new index of cardiorespiratory functional reserve derived from the relation between oxygen uptake and minute ventilation during incremental exercise Technical considerations related to the minute ventilation/carbon dioxide output slope in patients with heart failure Exercise testing for chronotropic assessment Download references Department of Sport Medicine and Functional Explorations-CRNH Auvergne The authors declare no competing interests Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41598-020-65770-y Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Newton North High School presented the Charles Dana Meserve Award one of the school’s most prestigious honors is the first Black student to win since the award was created in 1923 The Meserve Award is North’s oldest running award Students who merit it not only have displayed a high standard of academic excellence but have also made significant contributions to the community said his favorite classes were Advanced Placement Chemistry He is planning to study biochemistry at Yale University in the fall it leads you to even more questions,” Wright said I just feel like since I’m very curious about the world and how things work said the pandemic inspired her to pursue justice in public health Tarui plans to study biomedical engineering at Johns Hopkins University in the fall “I was really excited by the opportunities that existed specifically within the [area of] advancing health equity,” Tarui said “So that was a really big factor in me deciding to attend Johns Hopkins.” Principal Henry Turner said he is proud of Wright and Tarui’s achievements and commitment to the school community “They were true leaders in helping the rest of our school community to know what it meant to be a Newton North student,” he said Turner also said Wright’s achievement was both a recognition of the strides the school has made as well as a signal of the work still needed to be done “I think it was pretty eye-opening to many members of our community that we haven’t had a Black recipient for that long of our history,” Turner said “We’re really proud of our history as a school so I think that provided a lot of shock “I think it’s a great way to celebrate our community and at the same time a great acknowledgement of the work that we’ve got to do.” Wright said he learned he was the first Black recipient of the award when Turner told him during a graduation rehearsal “I was just surprised that in 99 years of the award, I was the first [Black] person to win it,” Wright said. “I think that kind of speaks to something at North, like having an achievement gap between Black students and the rest of the school.” In the summer going into his senior year, Wright said he participated in Summer Science Program, through which talented high school students gain hands-on research experience, where he helped design inhibitors for diseases. During his junior year he was part of a mentorship program, reading and conducting science projects with younger children in the Newton community. “It was nice to be the teacher — because I’m used to being in the student’s position — to see how it is to teach other people,” Wright said. Isongesit Ibokette, who taught Wright in AP United States History, also had him in an elective course called “Africa and the New World.” A presentation Wright gave in that class on the Belgian colonization of the Congo was so outstanding, Ibokette said, he had to postpone the rest of the presentations for the day so that other students could tweak their own projects. “When I wrote his letter of recommendation I just didn’t know where to stop,” Ibokette said. “Because this is a student that I know Yale University is just going to be very lucky to have on their campus.” David Bennett, a teacher at North who had Tarui for AP Chemistry and was a faculty adviser for a new student-led, faculty-facilitated group at the school called the Human Rights Council, said he was impressed by Tarui’s level of involvement in the school community. “It’s hard to imagine where she even had the time,” Bennett said. “She’s truly a wonderful individual. She’s one of those students who you’ll never forget because they’re such good people.” As part of the Human Rights Council, Tarui worked to address issues of inequality within the school. Principal Turner said the program came about as a result of several incidents of racism the school dealt with over social media in 2020. One step the administration took at that time was to reach out to students to hear their concerns on the issue. “One of the things that [students] felt like we needed to do a better job as an administration was to really make sure that students had a voice when those kinds of incidents occur, and to give feedback to administrators like myself,” Turner said. “They wanted more empowerment to be able to create change in their schools.” This year the group created an initiative to provide SAT Prep tutoring to students who may not have had access to private tutoring. Tarui, who is the first person in her family to attend a United States university, said her own experience applying to schools inspired her participation in the tutoring program. “I gained a lot of awareness around the various inequities that exist within higher education and the college application process in general,” she said. “So I became really motivated to want to do something to address those inequities to ensure that students from all backgrounds had access to higher education especially.” The Meserve Award was announced during a breakfast ceremony held in honor of the graduating class. Wright and Tarui both said, thankfully, they didn’t have to give a speech. “I had known about the Charles Dana Meserve Award because I had seen the plaque in the hallways,” Tarui said. “But I wasn’t expecting to get it at all, so I was really surprised when they announced my name.” Seamus Webster can be reached at newtonreport@globe.com. Home Delivery Gift Subscriptions Log In Manage My Account Customer Service Delivery Issues Feedback News Tips Help & FAQs Staff List Advertise Newsletters View the ePaper Order Back Issues News in Education Search the Archives Privacy Policy Terms of Service Terms of Purchase Work at Boston Globe Media Internship Program Co-op Program Do Not Sell My Personal Information Print Tufts of hair fell like rain outside La Cañada High School’s North Gym last Thursday as a group of students and teachers sacrificed their locks in a show of solidarity with young cancer patients for whom baldness isn’t an option students in the campus Bridge program and Associated Student Body collaborated with others to raise awareness and funds for the St a Monrovia-based nonprofit that organizes similar head-shaving events nationwide to help fund cancer research NEWSLETTER: Stay up to date with what’s going on in the 818 >> Bridge adviser Gavin Williams happily reported this year’s efforts had raised more than $10,000 with incoming donations still being tallied the students said they wanted to do something that brings the whole school together,” said a fuzz-headed Williams who’d had his own dome chromed at a March 4 assembly introducing the fundraiser everybody’s been donating in classrooms and talking about it.” 1/9 La Cañada High School student Ben Choi gets his head shaved by Bridge Program advisor Gavin Williams during fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 2/9 La Cañada High School principal Ian McFeat gets his head shaved during fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 3/9 La Cañada High School student Kyle Mysliviec gets his head shaved by fellow student and friend Alexa Tarui during fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 4/9 La Cañada High School 9th grader Adam Lujan gets his head shaved during fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 5/9 La Cañada High School students shaved their heads at the Bridge Program fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 6/9 La Cañada High School members of Bridge Program and those who participated in shaving their heads pose for a photo after fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 7/9 La Cañada High School science teacher Mark “Dr E” Ewoldsen gets his head shaved by head of security Tanya Wilson during fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 8/9 La Cañada High School science teacher Mark “Dr a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) 9/9 La Cañ ada High School students (l-r) CHarlie Weiss Elias Figueroa and Kyle Mysliviec shaved their heads at the fundraiser for the Baldrick’s Foundation at the school in La Cañada Flintridge a teacher and the principal participated in the fundraiser which aimed to raise about $10,000.  (Raul Roa / Staff Photographer) Williams said this year organizers instituted a “100 to shave/100 to save” structure to allow those too squeamish for a shaving to help the cause by raising enough to keep their hair intact Among the 20 or more male students and teachers who opted for the former was junior Jake Stolmack “Hair is a small sacrifice to make to raise awareness about something like cancer,” the 16-year-old reasoned even the hair on our heads is something we take for granted.” helped collect the pledge sheets and in-class donations on the day of the event She said that while no female students participated in this year’s shearing several donated tresses to the nonprofit Locks of Love and Pantene’s Beautiful Lengths program which harvest real hair for the manufacture of wigs for cancer patients “It’s actually really cool to see how involved students have become,” the junior said “To see students take money out of their own pockets without being asked to — it’s very heartwarming.” raised nearly $37 million last year to help fund pediatric cancer research partly through events similar to the one held at LCHS The foundation estimates about 175,000 children nationwide are diagnosed with cancer each year That sad fact is part of why junior Armand Manoukian insisted on sitting in the barber’s chair this year I’ve had the same haircut since the day I was born,” he said “(But) I’ve had family members touched by cancer said afterward the event demonstrates how much teachers students and staff care about doing things for the benefit of others Sara Cardine, sara.cardine@latimes.com Twitter: @SaraCardine La Cañada officials secure funds to tone down freeway traffic Nearly 60% of La Cañada’s greenhouse gas emissions come from cars, per climate report Musical parody of TV’s ‘Real Housewives’ takes a local turn Sara Cardine covers the city of Costa Mesa for the Daily Pilot where she spent six years as the news reporter covering La Cañada Flintridge and recently received a first-place Public Service Journalism award from the California News Publishers Assn which instilled in her a love for community news Subscribe for unlimited accessSite Map Please view the main text area of the page by skipping the main menu. The page may not be displayed properly if the JavaScript is deactivated on your browser Japanese version Going to the beaches during summer is one of the best ways to beat the heat and enjoy Japan has many beautiful beaches and many of them offer a variety of fun summer events and activities such as water sports many shops offer refreshing drinks and food Nishiki Beach is one of the popular beach destinations in Osaka well-known for its white sand and greenery During summer many water sports activities take place such as jet skiing windsurfing and events related to summer you can collect clams with your kids a fun activity that they will surely enjoy It also offers BBQ facilities to enjoy the beach more with family and friends relax and enjoying the ocean view Date: Opens from Early July to End of August Tannowa Tokimeki Beach is one of the well-known seaside destinations during summer in Osaka It offers a lot of activities and events related to summer Apart from the sandy shores and clean water they also have some facilities where you can enjoy BBQ Enjoy collecting clams and other shellfish with your kids they also have some fun games to participate and there are some classes on lifesaving and many more Sennan Marble Beach is one of the most beautiful beaches in Osaka recognized as “Lover’s Sacred Place” with a heart-shaped monument and white marble pebbles which many tourists enjoy It offers relaxation with stunning sunset views Enjoy the sightseeing and walking around the beach Rinku Marble Beach is also known for its white marble pebbles which are enjoyed by many tourists It is very accessible to get through near Rinku Town Station Apart from the beach where you can enjoy the beautiful view of the ocean you can also enjoy the stunning sunset view that gives relaxation Many fun activities are offered at the park side some events and festivals are held during summer Pichi Pichi Beach also known as (Hakotsukuri Beach) offers white sand and clean water The beach is open only during summer from July to August It is also accessible near to the train station During summer various lively activities are held such as the water sports activities and the Marine festival held in August and shops for rental in some activities on the beach You can also enjoy food and fun activities with your kids such as collecting clams Tarui Southern Beach also known as Rinku Minamihama Beach popular for its natural beauty with its clear blue ocean and greenery perfect for relaxation that gives refreshing vibes It offers various unique beach activities to enjoy sunbathing They have many shops offering rental and selling products to use for beach activities they also host lively music events including some food stalls and shops for souvenirs Hope this article helps you about the beaches in Osaka For more travel tips about Osaka check out the following articles ▽Subscribe to our free news magazine!▽ Greetings to all mommies I am a supermom from Philippines I worked and lived in Dubai for seven years I am happily settled here with my Japanese husband and our 7 months old baby I could only describe my almost 6 years of living here as a roller coaster ride more so I was able to witness firsthand the pros and cons of living in the country Those years were enough to give me quite personal and memorable experiences which I would be more than delighted to share with you