Japanese nurse Arisa Tsubata has trained around her work shifts for over a year to prepare for a final Olympic boxing qualifier in the hope of making it to the Tokyo Games this summer That dream was shattered after the International Olympic Committee (IOC) cancelled the boxing qualifier due to take place in June and said it would allocate spots to athletes based on their world rankings in recent years The change in criteria has effectively shut the door on many Olympic hopefuls such as Tsubata whose rankings are not good enough to earn them an automatic qualification for the Olympic Games in Tokyo Other qualifying competitions for the Olympics have also been cancelled the 27-year old quit her job at a major hospital in January to take on a less demanding and lower paid position at a smaller psychiatric clinic she has trained over three hours a day during the week and extra hours on Saturdays only taking Sundays off to rest or to get a massage who currently works at the Life Support Clinic in Tokyo "I had been working so hard for a year after the postponement of the Olympics and it's so frustrating that I don't even have the right to compete." will go ahead but questions remain over how it will hold the massive sporting event mid-pandemic The country is currently fighting a fourth wave of coronavirus infections "'Why did I aim for the Olympics when the coronavirus happened?' I asked myself," she said also wondering "who knew the coronavirus pandemic would come at this time?" Her feeling of frustration and uncertainty is shared by many athletes globally whose careers have been thrown into limbo after the pandemic dashed some people's life-long dreams of participating in the global sporting event The IOC has a June 29 deadline to wrap up qualifications for this year's Olympics and with the cancelled qualifiers it now has to allocate about 53 spots in boxing across several regions based on ranking points since 2017 the head coach of the country's national boxing team Santiago Nieva also remembers the "heartbreaking moment" when he delivered the news to four boxers "You feel like you're taking away their dreams," Nieva said Left: A photograph shows Tsubata and her friend Naomi Mizumura taken when they worked at the same hospital Right: Tsubata and Mizumura chat at a park Tsubata got into boxing about three years ago to lose weight but her training coaches quickly encouraged her to compete in the sport and she went on to win Japan's national boxing championship for the middleweight division in 2019 she has mixed feelings about whether the Olympics due to start in July should go ahead as cases rise considering fellow athletes waiting for this moment and especially seeing my chance being taken away I think the Olympics should happen," she said is massaged by a chiropractor after a boxing training session in Iruma she said it "might be difficult" for Japan to hold the Olympic Games if the spread of the coronavirus is not contained and is preparing for her international debut at a tournament in Russia this month She says it is too early to think about the Olympic Games in Paris in 2024 and worries she may be too old by then to keep up with the physical strength needed to compete "I can't say I am aiming for the next Olympics in Paris but what I can do is try to keep working hard step by step PHOTO EDITING MARIKA KOCHIASHVILI; TEXT EDITING ANA NICOLACI; LAYOUT JULIA DALRYMPLE Tsubata eats a banana and has a protein drink for breakfast before starting her shift at the clinic Tsubata checks the medicine stock with her colleague Ryohei Arakawa Tsubata collects gloves for her outpatients during an exercise therapy session she runs at the gym inside the clinic Tsubata reads a book as she travels to her boxing gym on the subway Tsubata and Mizumura have a dinner together at Mizumura's home Tsubata turns on her car's engine as she leaves Tajima boxing gym after training at night Tsubata talks to her trainers Kuroki and Okada during a break Tsubata trains with her trainer Masataka Kuroki Tajima boxing gym is pictured in the night as Tsubata trains Your browser does not support JavaScript, or it is disabled．Please check the site policy for more information Ishikawa Prefecture--Cheers and jubilation erupted at a public viewing event at the town hall here on May 26 as hometown hero Onosato pushed his opponent out of the dohyo and clinched a historic tournament victory The victory elicited joy among the 400 people in attendance as well as lifted the spirits of residents in Ishikawa Prefecture who have had little to celebrate since the devastating Jan His sumo today was aggressive and impressive,” said Raiya Yasui a 15-year-old vice captain of the Tsubata Minami Junior High School’s sumo team who once received training advice from Onosato The new 23-year-old komusubi secured the championship in the Summer Grand Sumo Tournament by defeating sekiwake Abi at Ryogoku Kokugikan in Tokyo Onosato captured the Emperor’s Cup in only his seventh professional tournament the fastest since the championship system was established in 1909 "I'm happy to be able to bring good news to the people of my hometown," Onosato said on May 27 Expectations are high for Onosato's future advancement to the prestigious ozeki and yokozuna top ranks I want to continue climbing the ranks and reach even greater heights," he said Onosato's achievement came at a much-needed time for residents and communities trying to get back on their feet Nearly five months after the New Year's Day earthquake approximately 3,500 people in the prefecture are still living in evacuation shelters who is currently taking refuge at an evacuation center in Suzu burst into tears as she watched the tournament on television I will never forget this moment,” she said Onosato joined his fellow wrestlers on visits to evacuation centers across the prefecture delivering relief goods and offering encouragement to those affected by the earthquake New komusubi Onosato grabs 1st title at fastest pace after debut ozeki all lose on 1st day for the 1st time since Showa Era SUMO/ Takerufuji grabs title on makuuchi debut ‘Sumo train’ back on track to public’s delight after 3 years Information on the latest cherry blossom conditions Please right click to use your browser’s translation function.) A series based on diplomatic documents declassified by Japan’s Foreign Ministry Here is a collection of first-hand accounts by “hibakusha” atomic bomb survivors chefs and others involved in the field of food introduce their special recipes intertwined with their paths in life A series about Japanese-Americans and their memories of World War II In-house News and Messages Copyright © The Asahi Shimbun Company. All rights reserved. No reproduction or republication without written permission. Volume 9 - 2018 | https://doi.org/10.3389/fimmu.2018.02276 This article is part of the Research TopicInhibitory Receptors and Pathways of LymphocytesView all 15 articles B cells express various inhibitory co-receptors including CD22 These receptors contain immunoreceptor tyrosine-based inhibition motifs (ITIMs) in the cytoplasmic region Although many of the inhibitory co-receptors negatively regulate BCR signaling by activating SH2-containing protein tyrosine phosphatase 1 (SHP-1) different inhibitory co-receptors have distinct functional properties and CD72 preferentially regulate tonic signaling in conventional B cells CD72 recognizes RNA-related lupus self-antigen Sm/RNP as a ligand This ligand recognition recruits CD72 to BCR in Sm/RNP-reactive B cells thereby suppressing production of anti-Sm/RNP autoantibody involved in the pathogenesis of lupus Siglec-G recognizes α2,3 as well as α2,6 sialic acids whereas CD22 recognizes α2,6 sialic acid alone Because glycoproteins including BCR are dominantly glycosylated with α2,3 sialic acids in B-1 cells Siglec-G but not CD22 recruits BCR as a ligand specifically in B-1 cells and regulates B-1 cell homeostasis by suppressing BCR signaling in B-1 cells recognition of distinct ligands determines functional properties of different inhibitory B cell co-receptors SHP-1 appears to be the dominant effector of CD22 because CD22 negatively regulates BCR signaling Differential functional properties of inhibitory B cell co-receptors Mouse B cells express various inhibitory co-receptors such as CD72 These receptors contain ITIMs in the cytoplasmic region and recruit SH2-containing phosphatases such as SHP-1 leading to down-modulation of BCR signaling Although many of these inhibitory receptors activate SHP-1 and Siglec-G inhibits development of lupus-like disease high tonic signaling phenotypes of conventional B cells SHP-1 activated by different co-receptors regulates distinct B cell phenotypes Because the roles of the ligands are extensively studied in CD22 and CD72 among SHP-1-activating B cell co-receptors I would like to discuss distinct functional properties of different inhibitory co-receptors and the role of ligand recognition in determining their functional properties by focusing on CD22 B cell phenotypes of mice deficient in inhibitory B cell co-receptors Siglec-G plays a central role in SHP-1-mediated regulation of B-1 cells whereas other inhibitory co-receptors play an auxiliary or no role in the regulation of B-1 cell homeostasis these alterations in conventional B cells are not observed in mice deficient in other inhibitory co-receptors such as CD72 Because development of autoimmune disease partly depends on the cleanness of the animal facility it is not possible to discuss small differences in the disease severity among the different mice housed in different facilities CD72−/− mice develop lupus-like disease that is clearly more severe than that developed in mice deficient in other inhibitory co-receptors CD72 appears to be a dominant inhibitory B cell co-receptor in the regulation of autoimmune disease Taken together, Siglec-G, CD22, and CD72 regulate B-1 cell homeostasis, tonic signaling of conventional B cells, and development of lupus-like disease, respectively (Figure 1; Table 1) suggesting that different inhibitory B cell co-receptors regulate distinct B cell phenotypes roles of endogenous ligands of SHP-1-activating inhibitory B cell co-receptors were not clear until a few years ago autoimmune response to RNA-related self-antigens such as Sm/RNP appears to be crucial in development of SLE CD72 negatively regulates BCR signaling induced by Sm/RNP but not the other antigens thereby specifically inhibits activation of B cells reactive to Sm/RNP Sm/RNP activates B cells reactive to Sm/RNP probably by inducing both BCR signaling and TLR7 signaling leading to the production of anti-Sm/RNP antibody crucial for development of lupus CD72 appears to inhibit development of lupus by inhibiting activation of Sm/RNP-reactive B cells CD22 does not regulate BCR signaling in B-1 cells because CD22 recognizes α2,6 sialic acid but not α2,3 sialic acid and Siglec-G regulate distinct B cell functions: CD22 regulates tonic signaling in conventional B cells Siglec-G regulates B-1 cell homeostasis and CD72 regulates autoimmunity Recognition of Sm/RNP induces association of CD72 with BCR in B cells reactive to Sm/RNP whereas recognition of α2,3 sialic acid induces association of Siglec-G with BCR in B-1 cells different inhibitory co-receptors associate with BCR in distinct B cell populations depending on the ligand recognition of inhibitory co-receptors thereby regulating distinct B cell functions development of lupus-like disease by CD72 and B-1 cell homeostasis by Siglec-G Recognition of endogenous ligands thus determines the B cell phenotypes regulated by CD72 and Siglec-G Further determination of ligands of inhibitory co-receptors and elucidation of the roles of ligand recognition may advance our understandings on how inhibitory co-receptors regulate development and differentiation of B cells and suppress activation of pathological B cells These studies may provide clues in understanding pathogenesis of immunological diseases TT conceived of this mini review and wrote the manuscript The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest Wang (Fudan University) for critically reading the manuscript The author's work was supported by JPSP Grant-in-Aid for Scientific Research 26293062 doi: 10.1146/annurev.immunol.021908.132541 Role of inhibitory BCR co-receptors in immunity Infect Disord Drug Targets (2012) 12:181–90 Pivotal advance: CEACAM1 is a negative coreceptor for the B cell receptor and promotes CD19-mediated adhesion of B cells in a PI3K-dependent manner Enzymatic and non-enzymatic activities of SHIP-1 in signal transduction and cancer Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling SHP-1 requires inhibitory co-receptors to down-modulate B cell antigen receptor-mediated phosphorylation of cellular substrates The SH2 domain containing tyrosine phosphatase-1 down-regulates activation of Lyn and Lyn-induced tyrosine phosphorylation of the CD19 receptor in B cells Expression of dominant-negative src-homology domain 2-containing protein tyrosine phosphatase-1 results in increased syk tyrosine kinase activity and B cell activation CD22 and Siglec-G: B-cell inhibitory receptors with distinct functions B cell-specific deletion of protein-tyrosine phosphatase Shp1 promotes B-1a cell development and causes systemic autoimmunity Genetic segregation of inflammatory lung disease and autoimmune disease severity in SHIP-1−/− mice FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease Fcgamma receptors as regulators of immune responses CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice CD22 is a negative regulator of B-cell receptor signalling CD22 regulates thymus-independent responses and the lifespan of B cells B cell-specific loss of Lyn kinase leads to autoimmunity Siglec-G is a B1 cell-inhibitory receptor that controls expansion and calcium signaling of the B1 cell population Modulation of peripheral B cell tolerance by CD72 in a murine model Cd72(c) is a modifier gene that regulates Fas(lpr)-induced autoimmune disease Platelet endothelial cell adhesion molecule-1 (PECAM-1/CD31) acts as a regulator of B-cell development B-cell antigen receptor (BCR)-mediated activation Impaired dendritic cell maturation and increased T(H)2 responses in PIR-B−/− mice A model integrating tonic and antigen-triggered BCR signals to predict the survival of primary B cells The follicular versus marginal zone B lymphocyte cell fate decision CD22 x Siglec-G double-deficient mice have massively increased B1 cell numbers and develop systemic autoimmunity Role of PIR-B in autoimmune glomerulonephritis A 13-amino-acid motif in the cytoplasmic domain of Fc gamma RIIB modulates B-cell receptor signalling IgG-mediated enhancement of antibody responses is low in Fc receptor gamma chain-deficient mice and increased in Fc gamma RII-deficient mice Identification of CD72 as a lymphocyte receptor for the class IV semaphorin CD100: a novel mechanism for regulating B cell signaling CD72 negatively regulates B lymphocyte responses to the lupus-related endogenous toll-like receptor 7 ligand Sm/RNP RNA-associated autoantigens activate B cells by combined B cell antigen receptor/toll-like receptor 7 engagement Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus The ligand-binding domain of Siglec-G is crucial for its selective inhibitory function on B1 cells Siglec-mediated regulation of immune cell function in disease Proximity labeling of cis-ligands of CD22/Siglec-2 reveals stepwise alpha2,6 sialic acid-dependent and -independent interactions Immune regulation by the ST6Gal sialyltransferase Ablation of CD22 in ligand-deficient mice restores B cell receptor signaling CD22 ligand-binding and signaling domains reciprocally regulate B-cell Ca2+ signaling Paired immunoglobulin-like receptors and their MHC class I recognition Constitutive tyrosine phosphorylation of the inhibitory paired Ig-like receptor PIR-B Alpha2,6-sialic acid on platelet endothelial cell adhesion molecule (PECAM) regulates its homophilic interactions and downstream antiapoptotic signaling Citation: Tsubata T (2018) Ligand Recognition Determines the Role of Inhibitory B Cell Co-receptors in the Regulation of B Cell Homeostasis and Autoimmunity Received: 02 July 2018; Accepted: 13 September 2018; Published: 02 October 2018 Copyright © 2018 Tsubata. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Takeshi Tsubata, dHN1YmF0YS5pbW1AbXJpLnRtZC5hYy5qcA== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. 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Send help right to the people and causes you care about Your donation is protected by the GoFundMe Giving Guarantee The Tokyo Olympics opening ceremony began opened with a lone athlete — Japanese boxer Arisa Tsubata — running solemnly alone on a treadmill was denied an opportunity to actually compete at the games because her qualifying tournament was cancelled the 53 places up for grabs were allocated based on ranking points since 2017. Tsubata's ranking was not good enough for automatic qualification Her appearance in the opening ceremony was meant to reflect the hardships faced by both health workers and athletes during the pandemic and the one-year delay to the Olympics According to The Japan Times, the 27-year-old had quit her job at a major hospital in January to take a lower-paid position at a smaller psychiatric clinic and focus on boxing Since then she had trained over three hours a day during the week and even more on Saturdays in order to prepare for her qualifier "It's very disappointing," she told The Japan Times in May She added: "I can't say I am aiming for the next Olympics in Paris but what I can do is try to keep working hard A documentary featuring one of Japan’s former army personnel has become the latest target of anti-Japanese sentiments on Chinese social media with many criticizing the protagonist’s role in the Sino-Japanese War Thousands of individuals have descended on the review platform Douban leaving unfavorable ratings for the 2017 documentary “Life is Fruity,” which depicts the idyllic life of Shuichi Tsubata and his wife in their twilight years the late 90-year-old architect who briefly served in Japan’s navy has been widely criticized for his contributions during the Sino-Japanese War that killed and injured millions of Chinese between 1931 and 1945 The rating spree on Douban started after a user posted details about Tsubata on the site over the weekend nearly 20,000 people had given the documentary the lowest rating — one out of five stars — causing its total score to fall from 9.3 to 8.7 out of 10 in just a few days Many users on Douban have accused Tsubata of designing fighter planes for Japan and ignoring the suffering of Chinese people “I had watched the film many times before and felt comfortable, but did not expect the protagonist to be a ‘war criminal,’” a Douban user wrote on Monday changing their rating from five stars in March last year to two stars Other Japanese war movies such as “Porco Rosso,” “Grave of the Fireflies,” “The Wind Rises,” and “Merry Christmas, Mr. Lawrence” are also under fire. Some of the films had previously been screened at domestic state-backed film festivals, including “Life is Fruity,” which was screened at the Asian Film Festival organized by China Film Administration in 2019 The Chinese nationalist rhetoric online has surged amid the 76th anniversary of the end of the Sino-Japanese War social media users have also taken aim at Japanese athletes during the Tokyo Olympics while Chinese actor Zhang Zhehan faces a domestic boycott after photos of him posing at a controversial shrine honoring Japanese war criminals surfaced online Meanwhile, not everyone panned “Life is Fruity” and its protagonist, with some arguing Tsubata did not even visit China during the war and retired from the navy shortly after being forced to join in 1945. Supporters also rushed to rate the film at the highest score on Douban in defense of its artistic value, arguing that it’s irrational to express patriotism and remember history through hostile ratings “Do not let narrow nationalism shackle the spiritual wealth of human beings,” one Douban user wrote (Header image: Visual elements from Douban and People Visual Metrics details Chronic thromboembolic pulmonary hypertension is caused by incomplete resolution and organization of thrombi Blood flow dynamics are involved in thrombus formation; however only a few studies have reported on pulmonary artery blood flow dynamics in patients with chronic thromboembolic pulmonary hypertension the effects of treatment interventions on pulmonary artery blood flow dynamics are not fully understood The aim of the study was to evaluate pulmonary artery blood flow dynamics in patients with chronic thromboembolic pulmonary hypertension before and after pulmonary endarterectomy and balloon pulmonary angioplasty We analyzed patient-specific pulmonary artery models of 10 patients with chronic thromboembolic pulmonary hypertension and three controls using computational fluid dynamics In patients with chronic thromboembolic pulmonary hypertension flow velocity and wall shear stress in the pulmonary arteries were significantly decreased and the oscillatory shear index and blood stagnation volume were significantly increased than in controls Pulmonary endarterectomy induced redistribution of pulmonary blood flow and improved blood flow dynamics in the pulmonary artery Balloon pulmonary angioplasty improved pulmonary blood flow disturbance leading to vasodilatation of the distal portion of the pulmonary artery following balloon pulmonary angioplasty treatment and vascular endothelial dysfunction are all involved in thrombus formation the detailed mechanisms of the development of CTEPH remains unclear little is known about the mechanism by which blood flow dynamics in the pulmonary artery affect disease progression in patients with CTEPH the effects of these interventions on pulmonary artery blood flow dynamics and pulmonary vascular remodeling are not fully understood we evaluated pulmonary artery blood flow dynamics in patients with CTEPH using patient-specific models we explored the effects of PEA and BPA on pulmonary artery blood flow dynamics and pulmonary vascular remodeling The central thrombus type was classified as Level I and Level II disease and the peripheral type was classified as level III or IV disease Five central patients were treated with PEA between November 2016 and June 2018 BPA was performed in five patients with peripheral type CTEPH from December 2015 to August 2018 The control group included healthy individuals who underwent computed tomography (CT) for suspected atrial septal defects but did not have any abnormalities including atrial septal defects ECG-gated computed tomography pulmonary angiography (CTPA) with 0.5 mm slice was performed on all patients with CTEPH before treatment Follow-up CTPA was performed 3–6 months after treatment This study was approved by the Institutional Review Board of the Kyoto Prefectural University of Medicine (ERB-C-1157) All methods were carried out in accordance with the relevant guidelines and regulations The need for informed consent was waived by the research ethics board due to the retrospective nature of the study Work process of analysis using computational fluid dynamics 3D geometries of patient-specific pulmonary arteries in control individuals and patients with CTEPH were generated using computed tomography pulmonary angiography before and after PEA or BPA After the tetrahedral meshes and boundary-fitted prism layers were created a CFD simulation was performed to reproduce patient-specific pulmonary artery flow dynamics chronic thromboembolic pulmonary hypertension; PEA digital imaging and communications in medicine; STL The outlet boundary conditions were defined as pressure boundary conditions that reflected external forces from outside the analysis area Pulmonary artery pressure was measured by the Swan-Ganz catheter One of the main external forces is the reflection wave The following formula was used to determine the reflection: and the following term is added to the pressure outlet boundary condition: Each time step was set to 10–5 s in the transient flow simulation to sufficiently reduce the Courant number The convergence criterion was set to 10-5 times the residual for all degrees of the parameters at each time step and oscillatory shear index were evaluated at the peak systolic phase The WSS is a vector with force and direction toward the vessel wall at a certain point in time The OSI is an index of the fluctuation of the WSS in one cardiac cycle Continuous variables were assessed for normality Normal variables are reported as means ± standard deviations non-normal variables are reported as medians (interquartile ranges) We used a non-parametric test (Mann–Whitney U test or Wilcoxon signed-rank test) because of the small sample size Parameters calculated from CFD were averaged circumferentially from 10 points on the pulmonary artery walls at the midpoints of each pulmonary artery lobar branch as much as possible to avoid variation 32 branches treated with BPA were assessed (averaged circumferentially from five points in each branch) to evaluate the direct effect of BPA on pulmonary blood flow dynamics using a linear mixed effects model Statistical significance was set at p < 0.05 All statistical analyses were performed using the IBM SPSS Statistics software version 22 We compared the pulmonary artery blood flow dynamics of 10 patients with CTEPH with those of three control individuals, to evaluate the influence of blood flow in CTEPH. Table 1 shows the baseline characteristics of the patients with CTEPH Hemodynamic analysis demonstrated that the mean pulmonary artery pressure (mPAP) was elevated to 44.5 ± 9.5 mmHg and cardiac index (CI) was decreased to 2.1 ± 0.4 L/min resulting in increased pulmonary vascular resistance (PVR) as 12.2 ± 4.6 WU Comparison of pulmonary blood flow dynamics between control individuals and patients with CTEPH and blood stagnation volume (d) were simulated by CFD in the pulmonary arteries (proximal pulmonary artery and lower lobe branch of the right pulmonary artery) of control individuals and patients with CTEPH Stagnation was defined as a flow velocity < 0.01 m/s Data are presented as the median (interquartile range) The numbers in each box plot indicate the sample size for each group *p < 0.05 compared to control individuals; ns chronic thromboembolic pulmonary hypertension To assess the effect of the thrombus lesion site on pulmonary artery hemodynamics, we compared blood flow dynamics in patients with central and peripheral type CTEPH. The baseline characteristics of the two groups are shown in Table 1 There were no significant differences in mPAP and PVR between central and peripheral-type CTEPH Patients with central type CTEPH had lower right atrial pressure and pulmonary artery wedge pressure Comparison of pulmonary blood flow dynamics between central and peripheral type CTEPH and blood stagnation volume (d) were simulated by CFD in the pulmonary arteries of patients with CTEPH in comparison with the central and peripheral types Stagnation was defined as flow velocity of < 0.01 m/s Data are presented as median (interquartile range) Pulmonary blood flow dynamics before and after PEA and blood stagnation volume (d) were simulated using CFD in the pulmonary arteries of patients in comparison of before and after PEA Pulmonary blood flow dynamics before and after BPA and blood stagnation volume (d) were simulated by CFD in the pulmonary arteries of patients in comparison of before and after BPA Local pulmonary blood flow dynamics in the pulmonary artery treated by BPA and oscillatory shear index (c) were simulated using CFD in the proximal portion and distal portion of the pulmonary artery branches treated with BPA (d) The vessel diameters of the pulmonary arteries were measured before and after BPA *p < 0.05 compared with before BPA; **p < 0.01 compared with before BPA; ns the precise mechanism of incomplete clot resolution or development of organized thrombi is still unknown we explored pulmonary blood flow dynamics using patient-specific CFD models in patients with CTEPH and found that in addition to the decreased flow velocity and WSS OSI and blood stagnation were increased in the pulmonary artery of patients with CTEPH suspected that these may contribute in part to increased thrombogenicity both PEA and BPA improved pulmonary blood flow dynamics; however there were some differences in the improvement effect these are simulations in which thrombotic lesions are artificially created and not patient-specific models that consider patient-specific morphology and hemodynamics To accurately reproduce the patient's pulmonary artery flow dynamics we performed CFD simulations using hemodynamics from right heart catheterization and pulmonary artery geometry from CT pulmonary angiography before and after the treatment intervention Our simulation results provide the patients-specific virtual pulmonary artery blood flow in patients with CTEPH Although the survival rate of patients with CTEPH has improved in recent years focusing on pulmonary blood flow dynamics and pulmonary artery remodeling This study suggests that abnormal mechanical stress caused by turbulent blood flow around an organized thrombus contributes to CTEPH Both PEA and BPA improved these extraordinary hemodynamics; however there were some differences between these treatments PEA mainly improved the blood flow patterns in the proximal portion and lower lobe branch of the pulmonary artery as well as decreased blood flow and WSS in the upper lobe branches indicating redistribution of pulmonary blood flow BPA also improved both the blood flow patterns in the proximal and lower lobe branches of the pulmonary artery and stagnation of the pulmonary artery blood flow BPA did not cause a redistribution of blood flow in the pulmonary artery BPA increased the WSS in the distal portion of the pulmonary artery and decreased thrombogenicity Since our study was based on a small number of patients it is not clear whether these differences in pulmonary hemodynamics are due to differences in treatment or distribution of lesions disease severity is also associated with pulmonary artery blood flow dynamics We need a large number of patients to examine changes in pulmonary blood flow dynamics with different treatment modalities Working hypothesis of pulmonary artery blood flow dynamics before and after BPA this study included only a few patients in two institutes; potential confounders could have influenced the pulmonary blood flow dynamics this study used simulation data and did not directly measure parameters peripheral pulmonary vascular resistance is not considered the same because of the distribution and morphology of thrombotic lesions or microvasculopathy our results should be validated using 4D-MRI in the future this study considered the peripheral reflected waves of the pulmonary arteries and did not consider biological changes in vascular properties due to aging or changes after PEA surgery which can affect pulmonary artery compliance CFD analysis accuracy is compromised due to incomplete 3D model reconstructions that lacked branches or were terminated prematurely Our simulations could not provide peripheral artery blood flow since the geometries of pulmonary artery branches are truncated due to CT resolution These truncated geometries may have affected the calculation results we could not examine the pulmonary artery endothelial cell function and NO production in vivo we analyzed the pulmonary blood flow dynamics of patients with CTEPH before and after the intervention these results do not reflect the causes of the disease the results of this study suggest that abnormal mechanical stress due to organized thrombi might be involved in the CTEPH but further investigation is required to elucidate the etiology of CTEPH there is a decrease in blood flow velocity and WSS and an increase in OSI and blood stagnation in the pulmonary artery of patients with CTEPH PEA improves blood flow dynamics in the proximal portion of the pulmonary artery and redistributes pulmonary blood flow BPA improves pulmonary blood flow disturbances and decreases thrombogenicity in the pulmonary artery Our findings reveal previously undescribed treatment effects of PEA and BPA and provide novel insights into the physiology of CTEPH The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request 2022 ESC/ERS guidelines for the 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apoptosis-suppressive effects of shear stress on endothelial cells Refined balloon pulmonary angioplasty for inoperable patients with chronic thromboembolic pulmonary hypertension Download references We would like to thank Editage (http://www.editage.com) for the English language editing Nagoya City University Graduate School of Medical Sciences National Cerebral and Cardiovascular Center performed computational fluid dynamics analysis and participated in writing the manuscript designed and directed the study and wrote the manuscript provided technical support for the computational fluid dynamics analysis and helped with data interpretation provided pulmonary endarterectomy data and participated in data interpretation The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-023-33727-6 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Biomechanics and Modeling in Mechanobiology (2024) Sign up for the Nature Briefing newsletter — what matters in science She may be used to keeping her gloves up when defending herself in the boxing ring but as a nurse on the front lines of the coronavirus pandemic Olympic hopeful Arisa Tsubata's gloves are providing a defense of a different kind Tsubata has been balancing her huge responsibilities at a hospital near Tokyo with her boxing career while eyeing a spot in the women's middleweight event at the Summer Games next year I want to contribute to preventing the virus from spreading even if it's only by a little," the 26-year-old said in a phone interview She missed her bid for an Olympic berth last month at the Asia and Oceania qualifiers in Amman where she made a first-round exit in her international debut But she did not let the blow stop her from switching back to surgical gloves at her Saitama Prefecture hospital just days after touching down in Japan Amid a surge in the number of patients reporting coronavirus symptoms she says all staff members at her hospital have been chipping in Olympics: Swimming star Seto forcing himself to look past postponement Olympics: Shotgun toting priest has her sights set on unfinished family business Both our patients and our staff are very exhausted "We cheer each other up while sharing (our concerns)." Japan has seen an increase in the number of confirmed cases of infections in urban areas including about 700 from the Diamond Princess a cruise ship that was quarantined in February near Tokyo The government has requested people stay at home except for essential outings and called on the public to socially distance in an attempt to slow the spread of the highly contagious virus The outbreak has also led to cancelation and postponements of sports events all over the world were postponed following repeated calls by athletes and sports' governing bodies to consider the virus' impact on training If the coronavirus abates and all returns to relative normality the Tokyo Olympics is set to take place from July 23 to Aug currently spends long hours at the hospital She works for about 10 hours from 8:30 a.m Her everyday work life has changed drastically in just a couple of months and instead does so in a well-ventilated environment "I really want people to stop going out without thinking about the consequences An additional outbreak can be prevented if we all exercise some patience," she said Tsubata is not the only athlete with skills in the medical field There are similar examples around the world Para triathlete Susana Rodriguez has been working as a doctor in Santiago de Compostela in Spain according to the International Paralympic Committee the goalkeeper for Australia's women's field hockey team has applied to work as a nurse at COVID-19 clinics will help treat patients in New York City after graduating from medical school whose boxing career only goes back two years the Olympics became a goal after winning her debut tournament at the national championships in October Since only two boxers competed in the middleweight division Tsubata was crowned champion after one win Women's boxing has been contested at the Olympics since its inclusion at the 2012 London Games but no female Japanese fighter has competed Japanese boxers Tsukimi Namiki and Sena Irie claimed their spots in the women's flyweight and featherweight divisions With the final qualification meet expected to take place next year Tsubata hopes to secure a spot at the Tokyo Games while still prioritizing her all-important work Due to the scale of virus-related deaths across the world Tsubata finds it difficult to see how the Olympics will be considered a celebration she still wants to "earn the chance" to be there next year in Tokyo to show her appreciation to all the people who have supported her along the way To have the latest news and stories delivered to your inbox Simply enter your email address below and an email will be sent through which to complete your subscription Please check your inbox for a confirmation email Thank you for reaching out to us.We will get back to you as soon as possible National Report KANAZAWA—Close to 900 people suffered from food poisoning after eating at a “nagashi somen” restaurant in Tsubata Nagashi somen is a practice in which customers use chopsticks to try to scoop up thin somen noodles as they flow down a bamboo chute filled with running water The Ishikawa prefectural government announced on Oct 6 that 892 people were certified with food poisoning after dining at the restaurant between Aug The prefectural government said 1,298 customers submitted complaints They came from 18 prefectures around Japan salt-grilled mountain trout or shaved ice came down with the symptoms leading the prefectural government to check on the springwater the restaurant used The prefectural government ordered the restaurant to suspend operations The restaurant is normally only open during the summer but staff were unable to check on the water quality this year due to damage caused by heavy rains in mid-July The restaurant plans to go out of business after paying compensation to the victims Prefectural government officials said this was the largest number of food poisoning victims in a single case in Ishikawa since the start of the Heisei Era (1989-2019) Kyoto eateries whip up industry certification for virus controls Local campaigns seek to attract tourists back after curbs lifted Compliant bars in Okinawa end up with less in relief money Popular dining experiences in Japan halted over virus fears Alcohol-related restrictions to end in Tokyo No reproduction or republication without written permission Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors Metrics details Although drug distribution in tumor tissues has a significant impact on efficacy conventional pharmacokinetic analysis has some limitations with regard to its ability to provide a comprehensive assessment of drug tissue distribution Erlotinib is a tyrosine kinase inhibitor that acts on the epidermal growth factor receptor; however it is unclear how this drug is histologically distributed in lung cancer We used matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to analyze erlotinib distribution in the tumor and normal lung tissues of a mouse xenograft model and patient with non-small cell lung cancer LC-MS/MS showed that the erlotinib tissue concentration in the xenograft tumor tissue was clearly lower than that in the normal tissue at the time of maximum blood concentration MALDI-MSI showed the heterogeneous distribution of erlotinib at various levels in the murine tissues; interestingly erlotinib was predominantly localized in the area of viable tumor compared to the necrotic area MALDI-MSI showed that there were different concentrations of erlotinib distributed within the same tissue For drug development and translational research the imaging pharmacokinetic study used the combination of MALDI-MSI and LC-MS/MS analyses may be useful in tissues with heterogeneous drug distribution erlotinib distribution in patient tumor tissue has never been clearly shown by histology It seems to be useful that the innovative MSI technique translate into the visualization of erlotinib distribution in microscopic level as the no-labeling technique The aim of this study was to use a combination of matrix-assisted laser desorption ionization (MALDI)-MSI and liquid chromatography-tandem mass spectrometry (LC-MS/MS) to evaluate the distribution of erlotinib in the tumor and normal lung tissues of a mouse xenograft model and patient with non-small cell lung cancer Serum and tissue erlotinib concentrations in the mouse xenograft model (A) Serum erlotinib concentration by liquid chromatography-tandem mass spectrometry (B) Erlotinib concentrations in the tissue sections was compared between tumor and normal lung tissues Blue bar indicates erlotinib concentration by liquid chromatography-tandem mass spectrometry Purple bar indicates erlotinib ion intensity per section by matrix-assisted laser desorption ionization mass spectrometry imaging Error bar = standard deviation of replicate samples Comparison of relative erlotinib concentrations among necrotic and normal lung regions in the mouse xenograft model (A) Erlotinib tissue distribution by matrix-assisted laser desorption/ionization mass spectrometry imaging and regions of interest are shown (B) Relative erlotinib concentrations were estimated from the mass spectrometry images and liquid chromatography-tandem mass spectrometry using serial sections and normal mouse lung regions in the mouse xenograft model Error bar = standard deviation of replicate analysis for each region of interest Erlotinib tissue distribution in lung cancer with the epidermal growth factor receptor L858R mutation (A,C,E) Molecular images of heterogeneous erlotinib distribution at 6 h after single administration of 150 mg in the lung cancer core Scale bar indicates erlotinib quantity per pixel and upper limit of the scale bar indicates more than 0.2 pg/pixel erlotinib Molecular images were acquired at a step size of 60 μm Hematoxylin and eosin staining of the sections after acquiring the mass spectrometry image The most important goal of this study was to visualize the intratumoral distribution of erlotinib in both a mouse xenograft model and human lung cancer tissues using MALDI-MSI Although we have not been able to determine if the drug actually reached the tumor cells by the conventional pharmacokinetics study it may be possible to track this occurrence in tissue sections in the future Radioisotope and fluorescent labeling techniques are often used in drug tissue distribution studies; however they have significant drawbacks including the high label densities required the introduction of possible artifacts due to the labels themselves and the fact that some macromolecular structures are difficult to label this pharmacokinetic study using MALDI-MSI showed the heterogeneous tissue distribution of erlotinib in mouse and patient tumors No uniform concentration of erlotinib was observed even in the same tissue demonstrating the usefulness of this technique for evaluating drug tissue distribution Such drug tissue distribution studies by MSI may contribute to the reuse of drugs that were previously underestimated by LC-MS/MS analysis and may also reveal the usefulness of tissue therapeutic drug monitoring in translation cancer research Animal studies were carried out according to the Guideline for Animal Experiments drawn up by the Committee for Animal Experimentation of Shimane University which meet the ethical standards required by the law and the guidelines about experimental animals in Japan All animal experimental protocols were approved by the Animal Experiment Committee of the Shimane University (Permit Number: IZ27-76) PC-9 human lung cancer cells were subcutaneously implanted into BALB/c nu/nu mice erlotinib was orally administered at a dose of 25 mg/kg and tissue and serum samples were collected at 5 to 300 min after the administration of erlotinib Tissue samples of the dissected tumor and lung were flash-frozen in liquid nitrogen All of the tissues and sera were stored at −80 °C until subsequent use An 80-year-old nonsmoking woman exhibited a 35 × 25 mm ground-glass nodule in the left upper lobe (S1 + 2) of the lung on computed tomography during a medical check-up (Supplementary Fig. 2) She was diagnosed with non-small cell lung cancer (cT2aN0M0 stage IB) harboring an activating EGFT mutation (exon21 L858R) This trial was registered with UMIN 000009745 (Jan 10 The ethics committee of Shimane University approved the study protocol and the study was conducted in accordance with the principles of the Declaration of Helsinki We received written informed consent for the oral administration of erlotinib prior to surgery The patient received erlotinib at a dose of 150 mg tumor and normal tissues were surgically resected Then we sampled the flash-frozen tissues of lung cancer (tumor core and margin) and normal lung to analyze erlotinib distribution The patient did not experience any side effects and was released from the hospital 12 days after surgery The tissue was sliced into 8 μm thick slices with a Cryomicrotome (Leica CM 1950 Japan) into at least three serial sections The first and third sections were used for LC-MS/MS measurement of erlotinib concentration in the tissue whereas the second section was placed on indium tin oxide-coated (ITO) glass slides (Matsunami Glass Ind. Japan) and used for MALDI-MSI analysis of intra-tissue erlotinib distribution and for calculating the area of the tissue sections using the BZ-X710 microscope (Keyence The additional 16 serial sections of the tissue were used for LC-MS/MS measurement of erlotinib concentration in the small pieces that were cut by laser microdissection (Leica LMD 6500) multiple analysis of laser microdissection was difficult in this study Download references We thank all the people related to this study including patient and family This work was supported by grants from the Accelerating Regulatory Science Initiative the National Cancer Center Development Fund (26-A-20 and in part the Project for Cancer Research And Therapeutic Evolution Japan Agency for Medical Research and Development (16cm0106223h0001 Division of Medical Oncology and Respiratory Medicine Division of Clinical Pharmacology and Translational Research Exploratory Oncology Research and Clinical Trial Center supervised the study and contributed to editing of the manuscript performed the experiments and data analysis has received grants from Chugai Pharmaceutical Co. has received grants and others from Taiho Pharmaceutical Co. The other authors declare no potential conflict of interest about this study Download citation DOI: https://doi.org/10.1038/s41598-017-13025-8 Journal of Experimental & Clinical Cancer Research (2021) Analytical and Bioanalytical Chemistry (2021) Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology Newly promoted komusubi Onosato overpowered sekiwake Abi on Sunday, May 26 to win an emotional first championship on the final day of the Summer Basho got a right hand inside on the sekiwake and shoved Abi out quickly to improve to 12-3 Onosato made his elite division debut in the January 2024 tournament just days after his native prefecture was hit with a deadly earthquake on New Year's Day He contended for the title in the New Year's meet with an 11-4 record and followed that up with another 11-4 record in March's Spring Basho "I came close in January and March but could not get the title," Onosato said "So I'm really happy to get the title this time It sank in immediately that I won the championship." A huge throng of fans in Onosato's hometown of Tsubata erupted in cheers of joy when the 23-year-old thrust out Abi "I've been able to win the title and I think there were a lot of people watching in Ishikawa so I'm really happy," Onosato said "I'll keep working hard to get promoted higher." A loss by Onosato would have resulted in a playoff to decide the winner of the Emperor's Cup but he avoided an extra bout at Tokyo's Ryogoku Kokugikan with the convincing win over Abi Onosato becomes the first newly promoted sanyaku wrestler in 67 years to win the championship Annenyama was the last wrestler to achieve the feat when he went 13-2 to win the championship in the 1957 May tournament as a newly promoted komusubi Onosato began the tournament with a huge win over grand champion Terunofuji a win that knocked the yokozuna out of the 15-day basho "There were a lot of firsts for me in this tournament," Onosato said I just tried to stay calm and keep it business as usual." Onosato also took home the Outstanding Performance Award and the Technique Prize In the day's final bout, Kotozakura used an arm-lock throw to dispatch fellow ozeki Hoshoryu (10-5) and finish with an 11-4 record.  Top maegashira Daieisho remained in the championship race when he hauled down eighth-ranked Kotoshoho (8-7) to move to 11-4.  The Summer Basho was hit with a series of withdrawals in the first week. Terunofuji and ozeki Takakeisho pulled out after just one loss.  Ozeki Kirishima and former ozeki Asanoyama also pulled out due to injury March tournament winner Takerufuji withdrew just before the start of the tournament In other major Summer Grand Sumo Tournament bouts, eighth-ranked maegashira Takanosho shoved out Atamifuji to finish with a winning record of 8-7 It was a painful loss for top maegashira Atamifuji who could have been promoted to the sanyaku ranks with a win on the final day Atamifuji finished with a losing record of 7-8 and won't be getting a promotion No 4 maegashira Ura put a stop to the rot when he snapped an eight-bout losing streak by bulldozing Wakamotoharu out to pick up his seventh win against eight losses Third-ranked maegashira Takayasu deployed a superb overarm throw to send Gonoyama sprawling to the dirt surface while improving to seven wins Further down the ranks, makuuchi division debutant Oshoma shoved out 10th-ranked Kinbozan (8-7) to finish with an impressive 10-5 record Author: Jim Armstrong The author is a longtime journalist who has covered sports in Japan for over 25 years. You can find his articles on SportsLook You must be logged in to post a comment ' + scriptOptions._localizedStrings.webview_notification_text + ' " + scriptOptions._localizedStrings.redirect_overlay_title + " " + scriptOptions._localizedStrings.redirect_overlay_text + " TOKYO (Reuters) - Once thwarted by the pandemic Japanese nurse Arisa Tsubata is reviving her dreams to compete in boxing at the Olympics Tsubata emerged from a gritty gym on the outskirts of Tokyo onto the global stage on Friday when she performed a solitary run on a treadmill at the opening ceremony representing how athletes had to prepare for the pandemic-hit Games in isolation Tokyo organisers have scrambled to host the Games as the pandemic rages around the world affecting a wide range of decisions from athlete safety to spectator numbers Tsubata’s ambitions were shattered earlier this year when the pandemic caused qualifying events to be cancelled and changed criteria for spots at the Games the nurse had quit a job at a major hospital in January to take on a less demanding and lower-paid position at a smaller psychiatric clinic The 28-year-old told Reuters in May https://widerimage.reuters.com/story/japanese-boxing-nurse-has-olympic-dream-crushed-by-covid she was frustrated about not being able to compete at the Games not the next Olympics years away at Paris in 2024 Her appearance at the opening ceremony has changed her mind “I participated in these Olympics as a performer but I came to feel more strongly about wanting to participate in the Olympics as an athlete next time,” she told Reuters outside the National Stadium I will work hard to get a medal that has the best colour,” she added Tsubata said she was asked to perform by the organisers in April and her gig was finalised in June after she returned from a championship in Russia She rehearsed six times in July and kept it a closely guarded secret at the clinic and in the gym “I was trying to get more excited than nervous,” said Tsubata recalling the hours-long wait before performing The image of a lone Tsubata exercising at the opening ceremony has resonated with some viewers “Treadmill running person going nowhere for a really long time at the Opening Ceremony is basically a perfect metaphor for 2020-21,” said Twitter user “StopItILoveIt” Tsubata said she wanted to share her energy through the performance but so many people have been through so many things over the last year so I am hoping my performance helped them move forward - even if just a little bit,” she said Ju-min Park and Angie Teo; Editing by Antoni Slodkowski and Karishma Singh) FILE PHOTO : Arisa Tsubata practices with her work colleague Yuki Yamashita a karate practitioner and the head doctor at the the Life Support psychiatric clinic during a morning training session at the gym inside the clinic in Tokyo Arisa Tsubata poses in front of the Olympic Rings outside the National Stadium the main venue of the Tokyo 2020 Olympic Games FILE PHOTO: Arisa Tsubata performs during the opening ceremony of the Tokyo 2020 Olympics at the Olympic Stadium in Tokyo Arisa Tsubata shakes hands with a staff member of the opening and closing ceremony of the Tokyo 2020 Olympic Games through a fence outside the National Stadium the main venue of the Tokyo 2020 Olympic Games in Tokyo Arisa Tsubata Reporting by Kiyoshi Takenaka; additional reporting by Mari Saito; Editing by David Dolan & Shri Navaratnam Our Standards: The Thomson Reuters Trust Principles., opens new tab , opens new tab Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts. , opens new tabScreen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. © 2025 Reuters. All rights reserved many schools in areas severely damaged by the powerful New Year’s Day earthquake were silent as they postponed the start of the new semester One of the schools relatively unaffected by the earthquake held its opening assembly through a broadcast on Jan with students listening from each classroom a drill was conducted simulating a major tsunami warning for the Kahoku city coastline during which students climbed the stairs to the fourth floor of the school building A student affected by the disaster at her home in the seaside district “I evacuated to higher ground for about an hour (during the New Year’s Day earthquake and tsunami warning).” “We never know when an earthquake might occur so regular drills and preparedness are really important,” she said in areas severely affected by the earthquake there is no clear outlook for the reopening of schools all three elementary and junior high schools sustained damage The new semester was supposed to start Jan But a board of education official expressed uncertainty about reopening schools where the floors and ceilings of the second and third floors collapsed Of the 13 cities and towns in the hard-hit Noto Peninsula north of Kanazawa city--one in Toyama Prefecture and 12 in Ishikawa Prefecture--nine municipalities postponed the scheduled Jan Many of the schools don’t even know when they will be able to reopen Only schools in four municipalities currently have reopening plans The Ishikawa Prefectural Board of Education announced on Jan 9 that it is coordinating a mass evacuation of junior high school students in response to a request from Wajima city The officials said that around 400 students are enrolled in three junior high schools in the city and that the board will ask parents whether their children want to relocate to other schools Arrangements are being made for schools to accept these evacuees Delays in the start of the new semester were also seen in senior high schools located near Asaichi-dori Street (the Wajima morning market) where a large fire broke out Although the flames did not reach the school Nanao High School also postponed starting the school term on Jan but opened its classrooms that day to senior students for self-study in preparation for university entrance exams Nearly all of the approximately 190 seniors plan to take a unified university entrance exam on Jan “Some students lost all their study materials and exam slips because their houses were completely destroyed," said Principal Tetsuya Higami "Some families find it difficult to come to the school to pick up academic records to be sent to universities.” and I feel so lonely,” said Kokone Shokaku a third-year junior high school student who is taking shelter at a community center in Wajima She expressed her struggles with life in the evacuation center finding it difficult to focus on her studies about 10 children were evacuated and Kokone played board games with them many of them moved to Kanazawa and other cities “I really want to see everyone again,” Kokone said who is supporting shelter operations at a community center sent her two sons--one in junior high school and the other in elementary school--to stay with relatives in Tsubata town they would not be able to eat enough food,” she said The school in Tsubata accepted her sons even though they didn’t have school uniforms and textbooks for them but it’s unclear when schools in Wajima will return to normal,” the mother said who evacuated with her family of seven to the gymnasium of Wajima Senior High School With university entrance exams approaching the prolonged evacuation life has made her so tired that she often ends up sleeping wrapped in a blanket in the afternoon and his family members have been sleeping in their car along with their dog so I’m struggling to keep up both physically and mentally.” He said he has been unable to motivate himself to continue with his studies I am thinking of selecting a different school for my entrance exam.” who evacuated with her two children aged 6 and 3 to Wajima Junior High School expressed concern about the ongoing lack of water and the difficulties in maintaining their hygiene “It’s hard for the children to keep wearing masks all the time,” she said She added that her children love physical activities but are hesitant to play freely at the evacuation center: “I think some people might be bothered by the noise.” (This article was written by Masayuki Takashima Students who are menstruating can take make-up entrance exams 2021 - 3.28pmsharesShare1 / 27Arisa Tsubata runs on a treadmill during the Opening CeremonyOlympic boxing hopeful Arisa Tsubata is one of three athletes who performed by working out signifying how athletes have had to train in isolation during the pandemic who is also a nurse who has treated COVID-19 patients during the pandemic missed qualifying for the Games after the pandemic forced a change to the process 2 / 27Drone display over the main stadiumA drone display is seen over the top of the stadium during the Opening Ceremony of the Tokyo 2020 Olympic Games 1800 drones flew above the stadium to form a globe in the sky "Pretty incredible drone globe over the stadium," ABC's James Longman tweeted 3 / 27Fireworks over the main stadiumFireworks are seen erupting from the roof of the main stadium during the Opening Ceremony of the Tokyo Olympic Games 4 / 27Fireworks over the main stadiumFireworks light up the night sky above the main stadium at the beginning of the Opening Ceremony for the Tokyo Olympic Games of 2021 5 / 27Empty seats in the main stadium during the Opening Ceremony for the Tokyo Olympics 2021.Empty seats in the main stadium during the Opening Ceremony for the Tokyo Olympics 2021 6 / 27The Japanese flag enters the stadiumThe Japanese flag is brought into the main stadium during the Opening Ceremony for the Tokyo Olympic Games 7 / 27The Olympic ringsThe Olympic rings are displayed during the Opening Ceremony for the Tokyo Games 8 / 27Argentina Olympic teamThe Argentinian Olympic team enters the main stadium during the parade of athletes at the Opening Ceremony 9 / 27Great Britain enters the stadiumFlag bearers Hannah Mills and Mohamed Sbihi of Team Great Britain leads their team out during the Opening Ceremony of the Tokyo Olympic Games 10 / 27Australian athletes enter the stadiumFlag bearers Cate Campbell and Patty Mills of Team Australia lead their team in during the Opening Ceremony of the Tokyo Olympic Games 11 / 27Australia enters the stadiumFlag bearers Cate Campbell and Patty Mills lead the Australian team into the stadium during the Opening Ceremony of the Tokyo Olympic Games 12 / 27Australian team marches in the opening ceremonyThe Australian Olympic team marches in the Opening Ceremony of the Tokyo Games 13 / 27Australian athletes make their way into the stadium during the opening ceremony of the Tokyo Olympics 2021.Australian athletes make their way into the stadium during the Opening Ceremony of the Tokyo Olympics 2021 14 / 27The parade of nationsAthletes march into the main stadium during the parade of nations at the Tokyo Olympic Games Opening Ceremony 15 / 27Pita Taufatofua leads out TongaTaekwondo practitioner Pita Taufatofua leads the Tongan team out at the Tokyo Olympics It's the third time he's had the honour after the 2016 Rio Games and the 2018 Winter Olympics where he competed in the 15km freestyle skiing race 16 / 27Russian Olympic teamThe Russian Olympic team enters the stadium The Russian team walked out with a neutral flag and under the acronym of ROC which stands for Russian Olympic Committee Russia was sanctioned by CAS for several doping violations in 2020 banning it from all major sporting events for two years 17 / 27Japan enters the stadiumThe Japanese Olympic team enter the stadium during the Opening Ceremony with flagbearers Yui Susaki and Rui Hachimura leading the way 18 / 27The Olympic flag entersThe Olympic flag is carried into the main stadium during the Opening Ceremony for the Tokyo Olympics One of those carrying the flag was Australian shooter Elena Galiabovitch who has been heavily involved in the fight against COVID-19 in Australia over the past 18 months 19 / 27Drone display over the main stadiumDrones fly over the stadium during the Opening Ceremony of the Tokyo 2020 Olympic Games at Olympic Stadium on July 23 (Photo by Laurence Griffiths/Getty Images)Attribution: Getty20 / 27Naomi Osaka lights the cauldron.Tennis star Naomi Osaka lights the cauldron at the Tokyo Olympics 21 / 27Naomi Osaka lights the cauldronTennis champion Naomi Osaka lights the cauldron to open the Tokyo Olympic Games Olympic boxing hopeful Arisa Tsubata is one of three athletes who performed by working out A drone display is seen over the top of the stadium during the Opening Ceremony of the Tokyo 2020 Olympic Games Fireworks are seen erupting from the roof of the main stadium during the Opening Ceremony of the Tokyo Olympic Games Fireworks light up the night sky above the main stadium at the beginning of the Opening Ceremony for the Tokyo Olympic Games of 2021 Empty seats in the main stadium during the Opening Ceremony for the Tokyo Olympics 2021 The Japanese flag is brought into the main stadium during the Opening Ceremony for the Tokyo Olympic Games The Olympic rings are displayed during the Opening Ceremony for the Tokyo Games The Argentinian Olympic team enters the main stadium during the parade of athletes at the Opening Ceremony Flag bearers Hannah Mills and Mohamed Sbihi of Team Great Britain leads their team out during the Opening Ceremony of the Tokyo Olympic Games Flag bearers Cate Campbell and Patty Mills of Team Australia lead their team in during the Opening Ceremony of the Tokyo Olympic Games Flag bearers Cate Campbell and Patty Mills lead the Australian team into the stadium during the Opening Ceremony of the Tokyo Olympic Games The Australian Olympic team marches in the Opening Ceremony of the Tokyo Games Australian athletes make their way into the stadium during the Opening Ceremony of the Tokyo Olympics 2021 Athletes march into the main stadium during the parade of nations at the Tokyo Olympic Games Opening Ceremony Taekwondo practitioner Pita Taufatofua leads the Tongan team out at the Tokyo Olympics The Russian Olympic team enters the stadium The Japanese Olympic team enter the stadium during the Opening Ceremony The Olympic flag is carried into the main stadium during the Opening Ceremony for the Tokyo Olympics One of those carrying the flag was Australian shooter Elena Galiabovitch Tennis star Naomi Osaka lights the cauldron at the Tokyo Olympics Tennis champion Naomi Osaka lights the cauldron to open the Tokyo Olympic Games The Hurricanes have been purring since Ruben Love shifted from fullback to No.10 Here's our Super Rugby Pacific team of the month Laurie Daley is facing a welcome headache after several outsiders for Origin I selection put themselves in the frame during Magic Round When Ferrari took the covers off a special one-off livery it will run at this weekend's Miami Grand Prix the reaction from fans was swift and brutal The NRL's newest team are less than two years away from entering the fray and they will need to move fast from a recruitment perspective The decision has not yet been made official but the Aussie rookie has reportedly been tapped on the shoulder by Alpine Phil Gould and Paul Gallen have gone head to head over whether the penalty that decided Sunday's NRL blockbuster would be given in a grand final Many were surprised when Ezra Mam was suspended for only nine matches Phil Gould has implied it should've been longer please disable the ad blocking feature and reload the page This website uses cookies to collect information about your visit for purposes such as showing you personalized ads and content By clicking “Accept all,” you will allow the use of these cookies Users accessing this site from EEA countries and UK are unable to view this site without your consent KANAZAWA — Police have arrested a 50-year-old man from Tokyo on suspicion of selling an unauthorized reproduction of the weekly comic anthology that contained the first installment of the “Dragon Ball” manga series Tsubata Police Station in Ishikawa Prefecture said Wednesday it had arrested Takeshi Katahira on suspicion of infringing the copyright of publisher Shueisha Inc Katahira allegedly sold a counterfeit copy of Weekly Shonen Jump issue No 51 — originally published in 1984 — on an internet auction site in April A man in his 30s from Ishikawa Prefecture bought the item for about ¥180,000 Katahira claims he thought the magazine was authentic Authentic issues of the magazine are bound with staples but the counterfeit copy sold through the auction site had a glue binding The contents of the counterfeit magazine were identical to the original issue It even contained a reproduction of the reader survey postcard that accompanied the original issue The police are investigating how he came to be in possession of the reproduction of which he had listed multiple copies on the auction site The issue that carries the first installment of “Dragon Ball” is popular among collectors The man who unwittingly bought the counterfeit magazine on the auction site already had an authentic issue He reportedly said he bid on Katahira’s item because he “wanted one in better condition.” the texture of the paper in the copy he received raised his suspicions Shueisha posted a message on the Weekly Shonen Jump website to warn fans counterfeit magazines were being sold on internet auction sites Our weekly ePaper presents the most noteworthy recent topics in an exciting © 2025 The Japan News - by The Yomiuri Shimbun Mareho Kikuishi’s Your Forma light novel series is getting an anime adaptation as announced earlier during Dengeki Bungo’s 30th Summer Festival Event is credited for the original character designs but further details on the staff have not been revealed The light novel started serialization in 2021 under ASCII Media Works’ Dengeki Bunko imprint. There are currently five volumes out with the sixth one scheduled for this August. Yen Press is publishing the Your Forma light novels in English and describes the plot as: a miraculous “smart thread” technology initially developed to treat a massive outbreak of viral encephalitis But these convenient devices come with an invasive drawback—they record every sight and even emotion their users experience.For electronic investigator Echika Hieda diving into peoples’ memories via the Your Forma and hunting for evidence to solve the toughest crimes is all part of a day’s work she’s so good at what she does that her assistants literally fry their brains trying to keep up with her After putting one too many aides in the hospital the top brass finally furnish Echika with a partner on her level a brilliant yet cheeky android named Harold Lucraft Does this unlikely duo have what it takes to resolve their mutual suspicions and avert a deadly technological infection from sweeping across the globe before it’s too late?Your Forma won the 27th Dengeki Novel Prize Author Kikuishi commented on the announcement saying: “I would like to thank you for giving us the opportunity to have an anime adaptation I was overwhelmed by the enthusiasm of the production team and I myself was also very inspired by them Please look forward to the rebirth of Your Forma as an animation work.” A manga adaptation of the novel by Yoshinori Kisaragi is also ongoing The official website for the anime has been launched.Source: Press Release©Mareho Kikuishi 2023 Following the powerful earthquake that hit central Japan on New Year's Day authorities have started accepting applications for temporary housing in quake-hit municipalities and other areas a total of 27 municipalities in the prefectures of Ishikawa and Toyama have started accepting applications for "deemed temporary housing" provided by the local government about 6,500 vacant public residences are available in municipalities nationwide: ▼Toyama Prefecture ▼Toyama City ▼Takaoka City ▼Uozu City ▼Himi City ▼Numerikawa City ▼Kurobe City ▼Tonami City ▼Oyabe City ▼Nanto City ▼Imizu City ▼Kamiichi Town ▼Tateyama Town ▼Nyuzen Town ▼Asahi Town ▼Niigata Prefecture ▼Niigata City ▼Nagaoka City ▼Sanjo City ▼Shibata City ▼Ojiya City ▼ Kamo City ▼ Tokamachi City ▼Mitsuke City ▼Tsubame City ▼Itoigawa City ▼Gosen City ▼Joetsu City ▼Sado City ▼Minamiuonuma City ▼Tainai City ▼Aga Town ▼Yuzawa Town ▼Fukui Prefecture ▼Fukui City ▼Tsuruga City ▼Obama City ▼Katsuyama City ▼Sabae City ▼Awara City ▼Echizen City ▼Sakai City ▼Heieiji Town ▼Minamiechizen Town ▼Echizen Town ▼Mihama Town ▼Takahama Town ▼Aoi Town Public housing is offered in all 47 prefectures and a list of municipal contact information is available on the Ministry of Land https://www.mlit.go.jp/jutakukentiku/house/jutakukentiku_house_tk3_000149.html (Japanese only) Some municipalities take longer to provide public housing than others Procedures for using deemed temporary housing and moving into public housing provided by local governments are available at each local government office The Covid-19 delayed Tokyo Olympic Games finally kicked off on Friday meWATCH and Mediacorp Entertainment YouTube channel. Glorious purpose: Team Singapore's contingent led by flag bearers Loh Kean Yew and Yu Mengyu The opening ceremony kicked off with a sequence — featuring Japanese boxer and nurse Arisa Tsubata running on a treadmill and other athletes on rowing machines and stationary bikes — meant to represent the isolation and challenges everyone endured in the last 18 months was training to qualify as an Olympic boxer but her dreams were dashed by the pandemic when the International Olympic Committee dropped the qualifiers and instead allocated spots to athletes based on their world rankings over recent years who’s ranked No.1 by the Women’s Tennis Association was the final torchbearer to carry the flame to the cherry blossom-inspired Olympic cauldron The torch relay started from Fukushima Prefecture's National Training Centre on Mar 25 and then across all 47 prefectures in the 121 days each country's representatives entered the stadium set to the soundtrack of orchestral arrangements of video game music — including Kingdom of Hearts DragonQuest and Final Fantasy — a tribute to Japan's video games industry Tonga taekwondo athlete Pita Taufatofua really knew how to make an entrance — by turning up bare-chested and all oiled up just as he did before at the 2016 Games in Rio and the 2019 Winter Olympics in Pyeongchang Todayonline.com and Today Online domains and apps are now part of 'Channelnewsasia.com' domain We know it's a hassle to switch browsers but we want your experience with TODAY to be fast Upgraded but still having issues? Contact us which runs between Tsubata and Wakura Onsen in Ishikawa Prefecture will resume service between Hakui and Nanao stations on Jan but the train will be able to run between Kanazawa and Nanao Service between Takamatsu and Hakui stations resumed on Monday The section between Nanao and Wakura Onsen has not yet been restored due to damage to bridges and other problems The Thunderbird limited express train from Osaka and the Noto Kagaribi limited express train from Kanazawa will also resume services from Jan The July issue of Kadokawa's Comic Alive magazine published the final chapter of Tsubata Nozaki's Kenki Koiuta ~Re:Zero kara Hajimaru Isekai Seikatsu † Shimeitan~ manga on Thursday The manga is a spinoff of Tappei Nagatsuki's Re:ZERO -Starting Life in Another World- light novel series and focuses on the past of the character Wilhelm van Astrea and how he came to be called the Sword Demon Nozaki launched the manga in Comic Alive in November 2018 Kadokawa published the manga's third compiled book volume in September 2020 Please view the main text area of the page by skipping the main menu. 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