This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Join us at the Akustika Fair at the Nuremberg Exhibition Centre from April 4-6 Meet The Strad team at stand F08 and pick up a free copy of the magazine The Strad Directory Jobs By 2024-02-05T08:00:00+00:00 Bruce Hodges hears the performance of Haydn Walker and Mendelssohn at the American Philosophical Society, Philadelphia Marlboro musicians sharing the joy of chamber music Music from Marlboro has become one of the world’s pre-eminent festivals in which both players and audiences go to be immersed in the joys of chamber music Philadelphia Chamber Music Society artistic director Miles Cohen commented both on the festival’s history and the time spent rehearsing for this concert (which clearly paid off) The evening began with Haydn’s Quartet in G major op.77 no.1 and it would be hard to imagine a foursome – Maria Ioudenitch Hayang Park and Christoph Richter – having more fun was matched by the gleeful precision in the final two movements Viola (1997) George Benjamin wrote that he wanted ‘to conjure an almost orchestral depth and variety of sound’ Beth Guterman Chu joined Park to realise his intentions as if forging a Mahler symphony in a mere nine minutes I was imagining a similar work called Violin but neither could emulate the throaty resonance that the composer – and this duo – mined so successfully Concert review: Musicians from Marlboro Read: Sugar vs caramel: comparing the sound of the ‘Joachim-Ma’ Stradivarius to that of other violins Concert review: Lucy Fitz Gibbon (soprano) Alexi Kenney, Lun Li (violins) Hélène Clément, Tanner Menees (viola) Yi Qun Xu (cello) William Langlie-Miletich (double bass) After the interval came a gorgeously textured excerpt from Walker’s Lyric for Strings anticipation was high for the final piece: Mendelssohn’s Quartet op.44 no.3 I’m happy to report that its exuberance did not disappoint This second volume from the American Viola Society shines a light on viola rarities Innovative sonatas from the byways of 17th-century Germany Persuasive advocacy brings a neglected Viennese figure to life US correspondent Thomas May reviews Midori’s performance of the Brahms concerto with the Seattle Symphony under guest conductor Anja Bihlmaier on 23 January 2025 An all-American celebration of the concept of home Fine musicianship can’t quite overcome a flawed programme concept Site powered by Webvision Cloud Crave Original Series SHORESY Scores Fifth Season Renewal Ahead of Season 4 Premiere Production Underway on Season 4 of Crave Original Comedy June 20 – 26: Crave Weekly Streaming Overview May 23 – 29: Crave Weekly Streaming Overview Metrics details the central aim of Project PICMAN is to correlate metabolic flexibility to measures of cardiometabolic health including myocardial diastolic dysfunction body fat distribution and severity of non-alcoholic fatty liver disease This cohort will form the basis of larger interventional trials targeting metabolic inflexibility in the prevention of cardiovascular disease Participants aged 21–72 years with no prior manifest atherosclerotic cardiovascular disease (ASCVD) are being recruited from a preventive cardiology clinic and an existing cohort of non-alcoholic fatty liver disease (NAFLD) in an academic medical centre A total of 120 patients will be recruited in the pilot phase of this study and followed up for 5 years Those with 10-year ASCVD risk ≥ 5% as per the QRISK3 calculator are eligible Those with established diabetes mellitus are excluded Participants recruited undergo a detailed assessment of health behaviours and physical measurements Participants also undergo a series of multimodality clinical phenotyping comprising cardiac tests Blood samples are also being collected and banked for plasma biomarkers ‘multi-omics analyses’ and for generation of induced pluripotent stem cells (iPSC) Extensive evidence points to metabolic dysregulation as an early precursor of cardiovascular disease We hypothesise that quantifiable metabolic inflexibility may be representative of an individual in his/her silent but high-risk progression towards insulin resistance The platform for interdisciplinary cardiovascular-metabolic-neurovascular diseases (PICMAN) is a pilot adipose tissue distribution has been established to play a role in CVD we aim to further study the association of metabolic inflexibility with measures of body fat distribution This leads to one of the objectives of our study to characterise the gut microbiome landscape in individuals with a spectrum of cardiovascular-metabolic function which hopes to help us uncover microbial mechanisms with both diagnostic and therapeutic potential More information is urgently needed to correlate metabolic flexibility to cardiovascular function extend its association to the presence or absence of insulin resistance or diabetes and to enable further studies on interventions The careful triangulation of cardiovascular and metabolic assessment of patients together with liver fibrosis assessment lends a unique and attractive opportunity using layers of multiple imaging and non-imaging-based biomarkers to map out the full range of normal to abnormal cardiovascular-metabolic function and associations We will plot these on the backdrop of the spectrum of fatty liver disease whilst the non-fatty liver disease control cohort will be used to benchmark the cardiovascular and metabolic phenotype in cross-section using a community living cohort free of cardiovascular events This pilot study will lay the foundation to kick-start larger detailed studies to discover novel surrogate markers for impaired metabolic flexibility opportunities to study new therapeutics that target metabolic flexibility The ultimate goal is to be able to steer our population away from the spiralling progression towards insulin resistance and ultimately adverse cardiovascular outcomes (Upper panel) Assessments and phenotyping performed; (lower panel) Timepoints of assessments and phenotyping To define norms for metabolic flexibility in a multi-ethnic Southeast Asian cohort of individuals without manifest ASCVD To map the association of metabolic inflexibility with cardiovascular measures of diastolic dysfunction and coronary and cerebral atherosclerosis To map the association of metabolic inflexibility with measures of body fat distribution To map the correlation between metabolic flexibility and insulin sensitivity along the spectrum of subclinical cardiovascular disease and severity of non-alcoholic fatty liver disease To map the associations of the gut microbiome as well as metabolomic and molecular markers with cardio-cerebrovascular measures All participants would provide informed consent to be included Recruitment of individuals takes place at NUHS where community-dwelling individuals without cardiac disease will be referred via outreach to primary care and community partners in Singapore Our inclusion and exclusion criteria are intended to offer inclusion of individuals not characteristically “high risk” for cardiovascular and metabolic disease this marks the traditional cut-off between low and elevated risk Individuals with diabetes mellitus have been found to have a higher incidence of cardiovascular disease making diabetes a cardiovascular disease equivalent we have chosen only to include those with pre-diabetes without manifest diabetes as defined by a HbA1c < 6.5% at initial screening with no prior diagnosis of diabetes by a physician All participants will undergo medical history review extensive lifestyle questionnaires encompassing diet Participants will undergo an extensive metabolic phenotyping assessment These comprise (a) indirect whole-body calorimetry (WBC) (c) Intravenous glucose tolerance test (IVGTT) and (d) Dual Energy X- ray Absorptiometry (DXA) scan each serving size of 200 mL comprising 30% fat (= 6.6 g) (10% saturated fat 15% protein (= 7.4 g) and 55% carbohydrates (= 26 g) Participants consume 400 mls of EnsureR Plus that provides 600 kcal of energy Body composition imaging. Participants will undergo body composition imaging via the AMRA scan27 which will provide outputs of compartmental adipose tissue quantification (visceral fat volume as well as muscle measurements (total thigh volume anterior and posterior volumes of left and right thighs respectively) muscle and bone mass based on the differential absorption by body tissues of X-ray photons of 2 energy levels It will provide outputs of total body fat percentage (as a percent of the body that is composed of fat) fat mass index (measured in the total amount of fat [kg] relative to height [in metres] android to gynoid ratio (based on the distribution of fat) skeletal muscle mass (including the percent of the body that is composed to skeletal muscle) appendicular lean mass to height ratio (that measures amount of lean mass in arms and legs relative to height) and bone density (estimated density per unit area and relative to a defined population based on the Z-score which compares bone density of the individual to that expected in the normal population adjusted to age and body size and also the T- score that is relative to a healthy gender-matched population at peak bone mass age) Blood (serum and plasma) will be sent for routine clinical chemistry including liver function test the following biomarkers will be collected: NT-ProBNP CT coronary angiogram (CTCA) with coronary artery calcium score and epicardial fat assessment will be performed to delineate the coronary vasculature and epicardial fat All patients will undergo vibration controlled transient elastography (VCTE) of the liver This will provide quantitative surrogate measures of hepatic steatosis (via the controlled attenuation parameter as well as non-invasive markers of hepatic fibrosis via the liver stiffness measurement (kPa) These will provide valuable information on associations and trajectories analysis relating extents of liver fat inflammation and/or fibrosis to cardiometabolic phenotypes and CVD risk NASH at presence remains a histological diagnosis While non-invasive markers may predict the presence of fibrosis there is yet to be a biomarker that reliably predicts NASH using the NAFLD cohort with biopsy proven and staged NAFLD we will be able characterise the stage of NAFLD and/or fibrosis to evaluate presence of NASH and/or fibrosis vs NAFLD and its associated CVD risk Peripheral blood mononuclear cells (PBMC) will be isolated from whole blood samples PBMC are separated from the plasma fraction of the blood samples by centrifugation Detailed flow cytometry profiling of hundreds of distinct immune cell subsets will allow their enumeration sorting and quantification based upon selected surface and signalling proteins This can be blended with an immunometabolic profile analysis (based on cellular and plasma markers) and allow downstream “omic” analysis of cell subsets and single cells and immune repertoire mapping/generation of immune libraries These cells would be banked and used for further genomic analysis Stool samples would be collected for the purpose of a microbiome analysis The gut microbiome will be profiled at a community microbial ecology level (i.e which measures the species richness and evenness within a single sample using well-published methods such as Shannon’s or Simpson’s index Then to compare the diversity between multiple groups or conditions to assess similarities between microbial communities We will also employ multivariate statistical methods like principal component analysis (PCA) to visualise and assess patterns in microbial community composition Finally statistical tests such as analysis of similarities (ANOSIM) or permutational multivariate analysis of variance (PERMANOVA) will be employed to determine significant differences in microbial diversity between patients with and without CVD Clusters of metagenomes associated with varying domains of metabolic health would be determined by the Dirichlet multinomial algorithms samples based on microbial community structure and the approximate number of clusters is determined by the lowest Laplace approximation score We will further internally validate the optimal number of clusters using an independent method (i.e To then determine the specific taxonomic and functional features in the amongst patients in PICMAN associated with the varying domains of metabolic health read counts will be transformed into relative abundances by normalisation to the total number of reads per sample stool and urine samples will be banked for further multi-omics and validation analysis Colocalization of QTL and existing GWAS datasets will allow for the identification of putative targets driving disease aetiology Data will be analysed using descriptive statistics we will present continuous variables as median and interquartile range and categorical variables as number (%) We will analyse data using the non-parametric Mann–Whitney U-test or Wilcoxon Rank Sum test for continuous variables and the chi-square test for categorical variables Other statistical analysis will be conducted as required Analysis will be performed using appropriate statistical software The seriousness of metabolic disease and its burden in Singapore is rising Fatty liver (NAFLD/NASH) represents a preceding or underlying condition especially where it is hypothesised that quantifiable metabolic inflexibility may be representative of an individual in his/her silent but high-risk progression towards insulin resistance and diabetes the undeniable cause of mortality and morbidity in patients with the wide spectrum of metabolic syndrome is CVD outcomes and events Through deep and contemporaneous characterisation of the cardio-metabolic phenotype of a wide group of Singapore patients represented by PICMAN we have an invaluable opportunity to converge the imaging We aim eventually to identify patients at the greatest risk of disease progression through novel means and uncover new disease biomarkers and targets for therapies Ethics approval was obtained under the National Healthcare Group Domain Specific Review Board All methods were performed in accordance with the relevant guidelines and regulations to the increasing incidence of modifiable CV risk factors missing risk factors among those who are seemingly well We see a clear need for data to provide material towards formulating focused implementation and adoption projects towards tackling this surging medical condition in Singapore We hypothesise that early CVD is sub-classifiable by inter-related myocardial-vascular-liver-metabolic-lifestyle-molecular phenotypes This study is the first deeply-phenotyped early subclinical CVD cohort in Singapore which will then serve as a foundational platform for biomarker and target discovery The substantial and unique preliminary dataset acquired will enable us to proceed to larger prospective observational studies as well as future interventional studies The causes behind these stenoses are largely unknown and this study will help elucidate parts of it we aim to investigate the role of metabolic inflexibility as an early marker in the pathogenesis of cardiometabolic disease Metabolic inflexibility is involved in the pathophysiology of insulin resistance the predominant factor linked to type 2 diabetes [4] It has also been associated with obesity and abnormal adipose tissue and skeletal tissue metabolism This offers the most direct link to the metabolic syndrome associated with the development of cardiovascular disease if detected early enough before the development of irreversible cardiometabolic disease this may serve as a useful biomarker to allow for screening of at-risk individuals as well as a therapeutic target Metabolic flexibility is calculated by a change in respiratory quotient (ΔRQ) as measured by the difference in RQ between the fasting state and after a liquid mixed meal challenge this shift in cellular fuel selection from a predominantly oxidative fatty acid metabolism to glucose oxidation (and vice versa) that characterises healthy metabolic flexibility during the transition in energy demands (e.g from fasting to fed states or from resting to exercise) is a process driven by insulin and the latter’s action on enzymatic activity in the biochemical pathways of glycolysis fatty acid biosynthesis and anaplerosis of the Kreb’s cycle mediated by metabolites fluxes between the cytosol and the mitochondrial matrix This delicate balance in fuel substrate shift is governed by the interaction between AMPK (master cellular energy sensor) and mTOR (master cellular nutrient sensor) at the molecular level AMPK which is activated by fasting and exercise promotes catabolism by upregulating fuel oxidation for energy release whereas mTOR which promotes anabolism by suppressing mitochondrial biogenesis by contrast is activated by feeding and insulin Given the tight coupling between metabolic flexibility and insulin action it is readily conceivable why metabolic flexibility correlates to insulin resistance metabolic flexibility or inflexibility not only correlates with insulin resistance it also reflects the physiological impact of insulin resistance on cellular energy homeostasis while tools such as the hyperinsulinemic euglycemic glucose clamp and intravenous glucose tolerance test may assess the insulin sensitivity with great precision these tests by themselves only evaluate glucose uptake but do not show the extent of impact on other aspects of metabolic physiology unlike the information that comes from the evaluation of metabolic flexibility The measurement of metabolic flexibility therefore offers additional insights into the derangement of metabolism beyond what insulin resistance can provide unlike the labour-intensive clamp and IVGTT experiments metabolic flexibility is easily measured with good reproducibility using indirect calorimeter mounted on a portable metabolic cart which is readily operated by a single clinician or a research personnel at a fraction of the cost of either insulin sensitivity methods above Such aspects of metabolic flexibility coupled with its lower costs justifies our choice for its usage in this present PICMAN study we will set out to assemble a larger cohort that leverages stronger statistical calculations especially for longitudinal follow up for outcomes we will target therapeutic interventions such as intermittent fasting lifestyle interventions or cardiovascular therapies with recently demonstrated successes: SGLT-2 inhibitors to assess their effect on metabolic flexibility and cardiometabolic function we hope to build upon this study to embark on future larger scale studies resource limitation only allows us to phenotype this cohort at a single time-point Efforts are underway to obtain further funding to allow future longitudinal phenotyping and interventional studies A further limitation is that some tests performed such as whole-body MRI for body composition profiling or metabolic assessments such as indirect hood calorimetry are expensive and are not immediately implementable in clinical care pathways Complementary and more readily-available tests such as DXA scans for assessment of fat distribution have been included to allow for the study of correlation and implementation in a clinical context The PICMAN study seeks to lay the foundations for further future larger scale and more experimentally ambitious studies based on the overarching hypothesis that metabolic flexibility is an early marker in subclinical cardiovascular disease indicating a point of timely intervention where the disease process is still reversible The importance of a deeply-phenotyped local cohort will allow us to study the progression of CVD in seemingly well adults data and materials would be made available upon request kindly contact the Principal Investigators Forecasting the burden of type 2 diabetes in Singapore using a demographic epidemiological model of Singapore Modelling NAFLD disease burden in four Asian regions-2019-2030 The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): A systematic review Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease A global view of the interplay between non-alcoholic fatty liver disease and diabetes Metabolic flexibility as an adaptation to energy resources and requirements in health and disease Loss of metabolic flexibility in the failing heart Regional differences in cellular mechanisms of adipose tissue gain with overfeeding Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study Mortality of NAFLD according to the body composition and presence of metabolic abnormalities Population study of the gut microbiome: Associations with diet Salt-responsive gut commensal modulates T(H)17 axis and disease High-level adherence to a Mediterranean diet beneficially impacts the gut microbiota and associated metabolome An untargeted fecal and urine metabolomics analysis of the interplay between the gut microbiome diet and human metabolism in Indian and Chinese adults Recent advances in modulation of cardiovascular diseases by the gut microbiota Mechanisms in endocrinology: SGLT2 inhibitors: Clinical benefits by restoration of normal diurnal metabolism? Cardiovascular risk in non-alcoholic fatty liver disease: Mechanisms and therapeutic implications Metabolic flexibility and dysfunction in cardiovascular cells Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: Prospective cohort study Design and validation of a histological scoring system for nonalcoholic fatty liver disease The role of mitochondrial adaptation and metabolic flexibility in the pathophysiology of obesity and insulin resistance: An updated overview Phenotypic flexibility as a measure of health: The optimal nutritional stress response test Body composition profiling in the UK Biobank imaging study Glucose effectiveness assessed under dynamic and steady state conditions Comparability of uptake versus production components MINMOD millennium: A computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test Association between insulin resistance and the development of cardiovascular disease Reference values for the Chinese population of skin autofluorescence as a marker of advanced glycation end products accumulated in tissue risk factors and screening of coronary heart disease in nonalcoholic fatty liver disease Non-alcoholic fatty liver disease association with structural heart systolic and diastolic dysfunction: A meta-analysis Measurement of mitochondrial respiration in adherent cells by Seahorse XF96 Cell Mito Stress Test Single-cell RNA sequencing technologies and bioinformatics pipelines Multi-electrode array technologies for neuroscience and cardiology The nature and identification of quantitative trait loci: A community’s view Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis Grading carotid stenosis using ultrasonic methods Administration and interpretation of the trail making test Association between adipose tissue characteristics and metabolic flexibility in humans: A systematic review Regional and ethnic differences among patients with heart failure in Asia: The Asian sudden cardiac death in heart failure registry Kong, G. et al. Prognostic outcomes in acute myocardial infarction patients without standard modifiable risk factors: A multiethnic study of 8680 Asian patients. Front. Cardiovasc. Med. https://doi.org/10.3389/fcvm.2022.869168 (2022) Intracranial arterial stenosis in Caucasian versus Chinese patients with TIA and minor stroke: Two contemporaneous cohorts and a systematic review Concurrent stenoses: A common etiology of stroke in Asians Metabolic health and cardiometabolic risk clusters: Implications for prediction Cardiometabolic risk in Canada: A detailed analysis and position paper by the cardiometabolic risk working group Download references The authors would like to acknowledge all the participants of the study and the staff at The National University Health System for their help with the conduct of the study The study has been funded by a grant from the National University Health System Research Office Mayank Dalakoti & Andie Hartanto Djohan National University of Singapore-Cambridge Cell Phenotyping Centre National University of Singapore Cardiovascular Disease Translational Research Program wrote the main manuscript text and prepared figures all authors reviewed and edited the manuscript and were involved in the execution of the study The necessary consent for publication has been obtained from all study participants and all authors The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-023-47407-y Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology By 2025-01-23T05:00:00+00:00 SOUTH KOREA: The urban rail network in Daegu has expanded following the opening of a cross-city suburban rail corridor and the extension of its metro The 61·9 km Daegyeong suburban rail line opened on December 13 linking Gumi in the northwest with Gyeongsan in the east running through Daegu station in the urban core Trains use existing tracks on the Gyeongbu main line some of which have been reconstructed and others newly built 70% was provided by the central government and 30% by local sources Services are operated by national carrier Korail. Hyundai Rotem supplied nine two-car trainsets Trains run every 20 min and an end-to-end journey takes 1 h The line achieved an average daily ridership of 28 000 passengers over its first month of operation three-station eastern extension of metro Line 1 opened on December 21 Construction began in April 2019 and the total project cost was 372·8bn won 70% of which was provided by the central government and 30% by local sources A further extension of Line 1 is planned at the eastern end This would add another 5 km to serve Geumho; trains would run onto the main line on this section The projected cost of the work is 205·2bn won and completion is planned by 2030 Under pressure to reduce commuting time across the country policymakers are developing suburban rail services around key conurbations many making use of spare capacity on existing main lines Two metro lines and a monorail serving 91 stations The southwest end of Line 1 from Jincheon to Jungangno opened on November 26 1997 A single station extension southwest to Daegok opened on May 10 .. Please enable JS and disable any ad blocker Photo: @isunwater via Twenty20November 1, 2019 A new survey of 2,500 consumers in the U.S. finds that those shopping online for gifts heading into the holiday season don’t simply want free delivery, they also want their orders delivered quickly. The research, part of a third annual report from Convey, found that “cost” was the most important factor related to shipping. It was cited by 64.3 percent of respondents, followed by “speed” at 18.7 percent. The number of people pointing to delivery time as important nearly doubled from last year when 9.7 percent gave that answer. Estimated delivery dates play a role in shopping decisions with 28.6 percent saying they are more likely to place an order that arrives within a week. Only 7.5 percent said that shipping dates do not affect their purchasing decisions. Free two-day shipping, what many see as the norm of online retail, was important to 79.3 percent of those surveyed. In-store pickup, as a point of comparison, was important to 30.8 percent of respondents. Delivery is a critical factor when it comes to the online shopping experience. Nearly 84 percent said that delivery is important in this regard, up from 73.6 percent last year. And not getting delivery right is a business killer, with 72.7 percent saying they are unlikely to do business with a site again after a poor delivery experience. Whether packages are on time or running late, consumers want to be kept in the loop. This is especially true of late deliveries as 98.3 percent say they want notification if a package is held up, up from 87.8 percent in 2018. Much of the changes in consumer attitudes about shipping seem to have been driven by Amazon.com’s delivery practices, which now offers Prime members free next-day delivery on millions of products sold on the site as well as free two-hour grocery deliveries. “For brands that like to think they aren’t competing with Amazon, the data clearly suggests that shoppers think they are,” said Kirsten Newbold-Knipp, chief growth officer at Convey, in a statement.  Retail chains, including Best Buy, Target, Walmart and others, have all responded with faster, free delivery options to rival Amazon.  DISCUSSION QUESTIONS: Do you agree that many consumers measure the delivery performance of other retailers based on their experiences with Amazon? Has the free and fast delivery of online orders become table stakes for all retailers? Retail industry’s premier source for news, analysis, and discussion. Lost your password? Don't have an account yet? Sign up By 2023-05-31T07:00:00+01:00 Carlos María Solare attends the birthday performance at the Royal Concertgebouw A fitting birthday celebration for viola legend Nobuko Imai Nobuko Imai has been based in the Netherlands for most of her life so Amsterdam’s iconic concert venue seemed an appropriate venue for her 80th-birthday celebrations The Concertgebouw’s Recital Hall was packed to the rafters as several generations of Imai students gathered to pay homage Proceedings were bookended by Handel’s Arrival of the Queen of Sheba and Bach’s Third Brandenburg Concerto both pieces arranged for viola ensemble and performed by graduates from Imai’s studios in Amsterdam Imai alumnus Sven Arne Tepl did the honours as master of ceremonies welcoming the grande dame on stage to a heart-warming ovation Her sagely thoughtful reading of Schumann’s Märchenbilder was sympathetically supported by Martijn Willers; Imai’s variety of articulation in the second movement’s quasi-hunting rhythms was perfectly gauged as were the contrasting moods of the third the final lullaby highlighting the dark timbre of her 1690 Andrea Guarneri Imai returned to the stage with Mihaela Martin and Frans Helmerson (her colleagues in the Michelangelo Quartet) for a touchingly lovely performance of Schubert’s one-movement String Trio Read: Nobuko Imai: Life Lessons Read: ‘It has to be connected to your soul’ - Nobuko Imai on Mozart Symphony no.40 Read: The viola should sound like a human voice, says Nobuko Imai The husband-and-wife duo of Veit Hertenstein and Peijun Xu dazzled in Lionel Tertis’s outrageously virtuosic two-viola take on Handel’s celebrated Passacaglia literally finishing each other’s phrases with perfectly matched colours and articulation while Hertenstein also contributed a beautifully voiced Largo from Bach’s Third Sonata Three graduates from Imai’s Geneva Conservatoire class – Tomoko Akasaka Megumi Kasakawa and Mariko Hara – were finely attuned in Tertis’s transcription of Beethoven’s Trio op.87 their contrasting timbres wittily highlighting the piece’s part-writing Imai’s Madrid class was represented by Wenting Kang Hayang Park and Bella Chich in a charmingly lilting Nachtstück by Max von Weinzierl Tōru Takemitsu wrote A Bird came down the Walk for Imai in 1970; without quite matching his mentor’s rich palette Takehiro Konoe brought forth much tonal beauty as did Timothy Ridout in Brahms’s F minor Sonata op.120 no.1 of which his magical Andante was a highlight an unsuspecting Imai was presented with the International Viola Society’s highest award the Golden Alto Clef ‘for exceptionally distinguished and unique contributions to the viola’ The capacity audience rose unanimously to congratulate her with a standing ovation US correspondent Thomas May speaks with Jessica Meyer about the synergy that fuels the charismatic violist’s work as a composer and collaborator Keeping it in the family: an exploration of a Russian musical dynasty Alex Laing reviews Kathy and David Blackwell’s books for young viola players seeking to improve their skills ※ This service is provided by machine translation tool Although it is assumed that European-trained Japanese psychiatrists assumed control of the management of the mentally ill at the turn of the twentieth century most afflicted individuals remained in their families' care and custody This talk explores both the history of how family-based care intensified in Japan despite the introduction of psychiatry as well as the challenges of writing such a history It shows how most histories based on the psychiatric archive have rendered invisible a crucial condition that enabled family-based care in the first place: a domestic and moral economy of caregiving dependent upon women's labor By tracing how this project has shifted in focus from psychiatry to women's domestic caregiving Kim aims to spark a conversation about the benefits of articulating the intellectual and affective processes through which historians grapple with archival materials and write histories Yumi Kim is a historian with research and teaching interests in histories of medicine and religion in East Asia and Pacific Empires in the nineteenth and twentieth centuries Her work offers a new feminist methodology for archival work and thus supports our series' vision of innovating various fields--in this case history of science--through a feminist lens Website: https://history.jhu.edu/directory/hayang-kim/ IGSF EAS History ISLA ISID English SSHRC-Connection Grants Feminist.asia [at] mcgill.ca Twitter February 15 (MExN): Three separate fire incidents were reported in Nagaland from February 13 to 15 two in Dimapur and one in Wokha district.  The first fire broke out on February 13 at Mishikito Village The team from Fire Station Dimapur (Central) responded to the site along with two fire tenders One house along with household belongings was gutted in the inferno Cause of fire is suspected to be from electrical short circuit and there was no casualty property worth Rs 15 lakh approximately was lost The response team led by Duty Commander ASI G Niamlungpou Gonmei could prevent the fire from spreading further to the immediate brick house and also a mini bus could be salvage.  The second report was a jungle fire at Lower Mount Tiyi The team from Wokha fire station led by Duty Commander Bumo Hayang Chang proceeded to control the fire Tree plantation and property worth Rs 50,000 approximately was lost in the fire The cause of fire could not be ascertained One katcha house along with household belonging was razed down in the inferno while property worth Rs 8 lakh approximately was lost Fire & Emergency Services team from Chümoukedima took 44 minutes to combat the fire which was suspected to be caused by electrical short circuit The response team was led by Duty Commander Do you think social media platforms are strengthening or weakening journalism in Nagaland The Morung Express is a people-oriented alternative newspaper based in Nagaland that was conceived from the Naga people’s historical realities and is guided by their voices and experiences It emerged from the well-recognized concept that the core of a free press is based on “qualitative and investigative” journalism Ensuring this is essential for contributing to an informed Naga public that makes sound decisions on issues that affect all spheres of life TAWANG-  Tawang team lifted the 500Kg Women and 580 Kg mixed category while Lower Subansiri team lifted the 640 kg men trophy in the final of the 2nd State level Jambey Tashi tug of war championship 2023 The state level tournament was inaugurated by MLA Dirang  Phurpa Tsering on 14th September 2023 in presence of MLA Lungla Tsering Lhamu and Chairman Bamboo research and Development agency Tungri Effa A total of 32 team from 14 district including ICR and 325 athletes participated in the tournament The closing ceremony was attended by MLA Nyamar Karbak as Chief guest and Hayang Mangfi as guest of honour The closing function and final tug of war at mega festival ground were witnessed by MLA Lungla Tsering Lhamu Commander Tawang Brigade Brigadier VS Rajput The National tug of war championship will be held in Tawang FROM 29th sept 2023 in which till so far 14 states have confirmed their participation and the finals of national tournament will be held on 1st of October 2023 informed President ATWA Arunachal Pradesh NL Kamin Speaking on the occasion MLA Hayang Mangfi remembered late Jambey Tashi as an inspiration for younger generation of the state He was not an ordinary citizen but an institution in himself he added MLA cum Advisor to Home Minister Nyamar Karbak lauded the ATWA for promoting tug of war which has very close connection with tribal games He expressed his hope that ATWA through its efforts will be able to represent our state in international events He also informed about the sports policy of present state government and job reservation and other attractive incentives to encourage youths from Arunachal Pradesh to represent in Olympics In the medal tally team shiyomi won bronze medal in Men’s category and mixed category while Women team kra dadi won bronze medal Team Tawang won gold in women and mixed category and team Kradadi and ICR bagged the silver in mixed and Women category respectively Team Tawang was also awarded with the best disciplined and Overall champion trophy and website in this browser for the next time I comment Δdocument.getElementById("ak_js_1").setAttribute("value",(new Date()).getTime()) NES President Bengia Tolum and other dignitaries were present on the award ceremony The Nyishi Elite Society (NES) on Tuesday felicitated meritorious students and newly elected and promoted officers of the community here at Dera Natung Government College At the XV NES Academic Excellence and Professional Achievers Award 2019 cum interactive programme with newly appointed and promoted officers 17 meritorious students and 84 achievers were felicitated Home Minister Bamang Felix who attended the award ceremony felicitated Toko Bittam for clearing JEE Advance (IIT) with 273 Ranks and for topping among the community in the Class XII (Science) with 94.8 % Tadar Neeb and Tadar Kul were felicitated for clearing the JEE Advance (IIT) securing 295 rank and 304 rank respectively Martina Tadar Alphonsa and Tadar Ane were felicitated for clearing NEET (MBBS) exam Nabam Jermin with 95% and Gollo Ninu with 94.6% were felicitated as first Toko Bittam was felicitated as topper from the community with 94.8% followed by Gungte Roshni with 94.6% and Bamang Aming with 93.2% respectively Trah Gungte was felicitated as topper from the community with 94.6% followed Hari Tuki with 86.2% and Donyi Camdir Tok with 84.6% respectively Toko Tato with 94.8% and Tadar Achal with 92.6% were also felicitated as first General Secretary NES advised the gathering to work for the welfare of the society and to put individual efforts to bring development in a society “Do not wait for MLAs or leaders to bring development but put up an effort on how you can change the society with your little actions and how you can inspire people with a good deed,” he added he asked to work hard and continue to perform and make the society proud Sports & Youth Affairs Minister Mama Natung called on Union MoS (independent charge) for Sports and Youth Affairs Kiren Rijiju here on Tuesday leading a delegation comprising of Chayang Tajo MLA Hayang Mangfi EKSWCO chairperson Dahey Sangno and host of East Kameng district public leaders particularly development of games and sports by focusing in developing state-of-the-art infrastructure and training facilities “My dream is to see at least 4 to 5 youths from our state representing the country in the next Olympic games,” Rijiju said while lamenting how shameful it is for the state as none of its sportspersons had ever represented the nation in Asian Games what to speak of winning medals due to apathy of past governments He shared about his Ministry’s plan to sponsor international quality soccer coaches to train budding footballers of Arunachal Rijiju assured to fund an astro-turfed soccer ground and stadia for East Kameng on priority and for rest of Arunachal Pradesh in a phased manner Citing that East Kameng has huge sports potential Rijiju assured Natung to establish an sports academy at Bana in East Kameng under the Sports Authority of India (SAI) He also informed the delegation about the proposal mooted by him for development of a large-scale mithun breeding farm in East Kameng district Natung apprised Rijiju about good initiatives of Pema Khandu Govt and constructive efforts of the Nyishi leaders and CBOs to make Itanagar capital a good and safe city for all communities Rijiju suggested Sangno to start mass outreach programmes for spreading awareness to create a positive atmosphere for development of tourism in the district 26 Feb: Nyokum Yullo of the Nyishi community was celebrated across the state with traditional fervor and gaiety on Wednesday Attending the Golden Jubilee Nyokum celebration at Chayangtajo in East Kameng district Chief Minister Pema Khandu urged the elders of the community to fulfill their responsibility to pass down the rich cultural heritage to the younger generations we are part of a history in making by participating in the Golden Jubilee celebrations of Nyokum at Chayangtajo the kids and children who are today presenting folk dances for us will be organizing the centennial jubilee celebration They will revisit today’s celebration and remember us We will be etched in the history of Nyokum celebrations in Chayangtajo,” he said Khandu announced a slew of new projects for the area worth Rs He informed that the list of projects sanctioned will be handed over to the local legislator Hayang Mangfi Admitting that one of the main issues of Chayangtajo ADC headquarters has been connectivity Khandu assured that soon this issue will be resolved He informed that six road projects are being vetted by the central government as inter-corridor roads totaling a length of 2178 kms the 391 kms Itanagar-Seijosa-Pakke Kessang-Seppa-Chayangtajo-Nyapin road is in the final stages of approval I assure to pursue the project with MoRTH so that work begins at the ground as soon as possible,” he informed the Frontier Highway will provide connectivity to several difficult areas of East Kameng,” he said “Connectivity is one of our top priorities,” he reiterated For welfare and convenience of Chayangtajo people Khandu assured to provide funds for development of the festival ground upgrade power transmission and roads to unconnected villages who had reached Chayangtajo by road on Tuesday He also laid foundation stones for projects worth Rs mostly under the Vibrant Village Programme The festival was also attended by industries minister Nyato Dukam advisor to CM and former home minister Bamang Felix Attending the Silver Jubilee Nyokum celebration at Yangte in Kra Daadi district Deputy Chief Minister Chowna Mein reaffirmed the government’s commitment to promote and preserve the rich cultural heritage of various tribes of the state “Nyokum Yullo is more than a festival; it is a living legacy an ancestral treasure passed down through generations It reminds us of the importance of safeguarding our heritage we must continue to take immense pride in our roots for they embody the spirit of being Arunachalee,” he said Mein assured to sanction fund for the construction of a cultural podium and open hall at Nyokum Yullo Ground in Yangte DyCM released a festival souvenir titled ‘Ane Yangte Mor-Pale,’ published by the celebration committee commemorating the Silver Jubilee Nyokum Yullo Celebration in Yangte circle Land management and civil aviation minister Balo Raja ZPC Charu Menia were present on the occasion Nyokum Yullo was also celebrated with great enthusiasm at Naharlagun on Wednesday mayor Tamme Phassang emphasized the significance of the festival in preserving the identity of the Nyishi people Urging the community to celebrate Nyokum Yullo irrespective of religious beliefs but if we stop celebrating our own festival today our traditions and culture will be forgotten in the future.” 24 Apr: A team comprising Environment & Forest Minister Mama Natung Seppa MLA Tapuk Taku and Chayang Tajo MLA Hayang Mangfi on Sunday assured to resolve the clean drinking water supply issue in Seppa township in East Kameng district within a month if the residents cooperate with the department The assurance came after a public consultative meeting held at the Nyokum Lapang here It was attended also by the secretary and the CE of the PHED and members of the East Kameng Social Welfare and Cultural Organisation Natung said that the residents of Kochi Nallah are creating hindrance and not allowing laying of DI pipes for fresh and clean water “The existing water tank at Kochi Nallah was constructed way back in the 1970s Due to rapid expansion of human settlement above the water tank The PHE&WS department had constructed alternative water tank at source but the residents are not allowing to lay 150 mm pipe and demanding compensation,” he claimed how can the district administration and the PHE department be able to resolve the drinking water issue?” Natung added and appealed to the public to “cooperate in laying DI pipes so that fresh water can be supplied.” “due to hindrance created by the residents the PHE department could not connect fresh water directly to the existing tank at Kochi Nallah.” He also appealed to the agitating youths to join the committee which is about to be constituted to resolve the issue “Instead of protesting and trolling on social media I appeal the youth to join in the committee and help the district administration to convince those residents who are not allowing the department to lay DI pipe On the corruption charge against the PHE department Natung stated that a fact-finding committee (FFC) is visiting the site “The SIC inquiry would be done only after the FFC report,” he said The Arunachal Times has accessed a copy of the report submitted by PHED Executive Engineer Bharat Sonam to the higher authority wherein Sonam claimed that “the reason behind water pollution is due to shifting of habitation at the upstream side of the head work the PHED has constructed a head work at the upstream side of the habitations in anticipation of fund from the government The laying of pipe was halted by the landowner(s) despite repeated request by JE/AE concerned this issue is yet to be addressed,” the EE claimed “There is an allegation that whole Seppa township is supplied water from this source The water from Kochi source is being supplied to a few colonies These issues will be addressed once the defunct RSF of Macha source is made operational This Kochi source will be kept on standby for emergency purpose too,” Sonam added in his report It is reported that the Kochi Nallah source is being used for supplying water to some colonies of Seppa township Staff Reporter Oct 27: The sports department on Tuesday inked a memorandum of understanding (MoU) with the Sports Authority of India (SAI) to establish a national centre of excellence (NCoE) at the Sangay Lhaden Sports Academy (SLSA) in Chimpu for boxing SAI Regional Director Dr Subash Basumatary and Arunachal’s Sports Director Tadar Apa signed the MoU The signing ceremony was virtually attended by union MoS for Youth Affairs & Sports Kiren Rijiju state Youth Affairs & Sports Minister Mama Natung Youth Affairs & Sports Secretary NT Glow the SAI will develop state-of-the-art sports facilities including playfields with allied facilities and other related allied sports facilities Rijiju congratulated the people of Arunachal especially Youth Affairs and Sports Minister Mama Natung and his department,” Rijiju said He asserted that the NCoE would provide world-class infrastructure and training to sportspersons and expressed hope that Arunachal would soon produce excellent sportspersons who would make the country proud on international stages could be added in the NCoE after the infrastructure is fully developed He asked the sports department to resolve the matter of land acquisition for shifting the NCoE to its permanent site in Rakap Natung expressed gratitude to Rijiju for making the MoU possible “I on behalf of the government of Arunachal thank the union MoS for youth affairs and sports in particular and the Modi government in general for extending this infrastructural support We are grateful to the union youth affairs and sports ministry and the SAI for their noble decision to set up the NCoE in Itanagar,” he said we are very much optimistic about winning medals in the 2028 Olympics and beyond,” Natung said adding that the admission procedure for the abovementioned sports disciplines has already been completed The minister informed that the required sports equipment He informed that the existing infrastructure of the SLSA would be used for day-to-day training activities in order to set up the permanent structure within the campus of SLSA.” SAI Director General Dr Subash Pradhan said that the signing of the MoU “is to bring world-class infrastructures to NCoE.” The Korean Cultural Center in Spain has announced the first concert of the Classical Music Cycle Korea 2025 featuring violist Hayang Park and pianist Chloe Jiyeong Mun will take place at the Royal Academy of Fine Arts of San Fernando in Madrid This year’s edition of the Classical Music Cycle Korea focuses on presenting artists who have previously performed in Spain through the Cultural Center’s initiatives both accomplished musicians in their respective fields are returning to the Spanish stage after their earlier appearances The concert program includes works by Robert Schumann The performance will be livestreamed on the Royal Academy’s YouTube channel the duo will conduct masterclasses for students at the Complutense University of Madrid’s Faculty of Fine Arts a result of collaboration between the Korean Cultural Center will be open to a limited number of attendees has garnered numerous accolades throughout her career including first prize at the 5th Tokyo Competition in 2022 She has studied at prestigious institutions such as the Reina Sofía School of Music in Madrid and is currently furthering her education at the Kronberg Academy in Germany gained international recognition after winning the Geneva International Competition in 2014 and the Busoni International Competition in 2015 She has collaborated with renowned conductors and orchestras worldwide establishing herself as a sought-after performer of her generation The Classical Music Cycle Korea is part of a broader initiative called Korea Season a project by the Korean Foundation for International Cultural Exchange (KOFICE) and the Ministry of Culture This project aims to showcase various aspects of Korean culture and arts in strategic countries throughout the year with the masterclasses following on March 21 The full program for Korea Season 2025 in Spain is expected to be announced in the near future © All rights reserved. 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