According to the organization’s citation for Embí
“his thought leadership and research led to the field of clinical research informatics
the safe and effective use of AI in health care
and data-driven learning health systems that improve health and care.”
Peter Embí
professor and chair of Biomedical Informatics
is among 100 newly elected members of the National Academy of Medicine (NAM)
the organization announced this week.
Formerly called the Institute of Medicine, NAM was established in 1970 as the health arm of the national academies
Both an honorific membership organization and an advisory organization
NAM is a national resource for independent
providing recommendations on a broad range of health-related issues
the organization collaborates closely with its peer academies
the National Academy of Sciences and the National Academy of Engineering.
Embí’s election comes with the following citation from NAM: “For being a pioneering physician-scientist whose career bridges health care
His thought leadership and research led to the field of clinical research informatics
and data-driven learning health systems that improve health and care.”
Election to the academy is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated outstanding professional achievement and commitment to service
New members are elected by current members through a process that recognizes individuals who have made major contributions to the advancement of the medical sciences
On its membership roster NAM currently lists 27 current and former faculty from Vanderbilt University Medical Center and Vanderbilt University
“It is always gratifying to see a member of our faculty recognized in this important way,” said Jeff Balser
President and CEO of Vanderbilt University Medical Center and Dean of Vanderbilt University School of Medicine
Embí’s insightful contributions to the field of biomedical informatics are increasingly involved in advancing the responsible use of artificial intelligence in health care and biomedical research
I want to offer my congratulations to Peter for this superb distinction.”
who holds the Directorship in Biomedical Informatics
he served as president and CEO of the Regenstrief Institute and professor and associate dean for Informatics and Health Services Research at Indiana University School of Medicine.
“I am deeply honored and humbled to be elected to the National Academy of Medicine
It is a privilege to join this esteemed group of leaders dedicated to advancing health and medicine,” said Embí
senior vice president for Research and Innovation
and co-director of ADVANCE (AI Discovery and Vigilance to Accelerate Innovation and Clinical Excellence) Center
“This recognition is a testament to the support of my mentors
and the encouragement of those who have guided me along the way
and I look forward to contributing to the academy’s mission to improve health for all.”
Embí earned a Bachelor of Science from the University of Florida
and his medical degree from the University of South Florida in Tampa
an informatics fellowship and a Master of Science in medical informatics and clinical epidemiology at Oregon Health & Science University
He then completed his rheumatology and immunology fellowship training at the Cleveland Clinic before joining the faculty at the University of Cincinnati College of Medicine.
In recognition of his contributions to the field
Embí has been elected to fellowship in the American College of Physicians
the American College of Medical Informatics
the American Medical Informatics Association and the International Academy of Health Sciences Informatics
He has also served in numerous national leadership roles
including as past president and chair of the board of directors of the American Medical Informatics Association
He also has served on many national advisory boards
including service on the Board of Scientific Counselors to the National Library of Medicine and on the National Advisory Council for the Agency for Healthcare Research and Quality
has been named to a National Academy of Medicine committee working to produce a code of conduct for the development and use of artificial intelligence in health
The 12 authors of the recommendations are mainly academics but also include leaders from tech companies Microsoft
senior associate dean for Informatics in the School of Nursing
Accenture Professor and director of Regional Informatics
have been elected to the Institute of Medicine (IOM)
JPMorgan will reclassify Kuwait and Qatar as developed markets and will soon begin their phased removal from its Emerging Markets Bond Index
from which the United Arab Emirates might also be removed next year.
The US-headquartered lender's EMBI tracks the performance of emerging market bonds — debt issued by countries with developing economies
These bonds typically carry higher risk but offer investors higher returns
The EMBI is closely followed by investors worldwide
In a report released Thursday, JPMorgan’s Global Index Research team said that Kuwait and Qatar will be removed from the EMBI in phases spanning a six-month period starting from March 31
The bank said that new bond issuances from these countries will no longer be included in the index
The change will affect two bonds Qatar sold on Thursday through the Ministry of Finance: a three-year $1 billion bond priced at Treasuries +30 basis points
and a 10-year $2 billion bond priced at UST +45
Qatar’s US dollar bonds handed investors 0.8% in returns this year
When compared to other emerging market bonds
Qatar’s sovereign spread over US Treasuries is around 67 basis points
compared to the emerging market average of 317
meaning that Qatari bonds are lower risk compared to other emerging market sovereigns
the bank said that the UAE’s cost-of-living ratio has exceeded the EMBI’s average for two years running
and if the Gulf state scores higher again in 2026
it will also be reviewed for removal from the list
“As investors we were waiting for this to happen,” Anders Faergemann
co-head of emerging market global fixed income at UK-based Pinebridge Investments
the investor base for Qatar and Kuwait will narrow by taking them out of the EM indices but we can still invest in both countries off benchmark.”
“This is a very healthy credit with a current account surplus — any external issuance won’t be a concern,” Faergemann added
saying that he had been making the case for Qatar to become a developing market credit for a while
Why it matters: The JPMorgan emerging market cluster is closely watched by many investors and the loss of two investment-graded sovereigns will increase the average risk for the asset class
Qatar has a weighting of 3.2% and Kuwait 0.6% in the EMBI Global Diversified grouping
Their removal would shift capital flows out of emerging markets and reduce opportunities for bond traders.
The US bank said the extra yield that investors demand to own emerging market bonds instead of US Treasuries — the benchmark safe haven asset — would widen by 11 basis points
Know more: Despite the move from emerging to developing markets
both Kuwait and Qatar are projecting deficits for 2025
Qatar approved a budget in December that projected a deficit of 13.2 billion riyals ($3.62 billion)
analysts from the Moody’s Ratings agency said that the significant improvement in Qatar’s financial metrics between 2021 and 2023 will be maintained in the medium term due to the government’s fiscal prudence and the country’s planned expansion of liquified natural gas slated for 2026 to 2028
3 that it projects its budget deficit to rise by 11.9% to 6.31 billion dinars ($20.4 billion) for the fiscal year 2025-2026
up from the 5.6 billion-dinar ($18.2 billion) shortfall estimated for the current fiscal year
30 that Kuwait may be able to sell debt for the first time since 2017
with the Council of Ministers set to approve a decree allowing the country to raise $65 billion over 50 years
Kuwait's previous debt law expired eight years ago and was not renewed due to tensions between the government and parliament around the OPEC member's heavy revenue reliance on oil prices and the resulting volatility.
But Kuwaiti Finance Minister Noura Al-Fassam told local media on Sunday that the debt law was "now in its final stages" and will help the country further develop infrastructure projects and support its capital expenditure.
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The elimination of Qatar and Kuwait from EMBI will take place over six months starting with the month-end rebalancing on March 31, JPMorgan’s Global Index Research team said in a statement. From now on, new bond issues from these markets won’t be included in the EM index, JPMorgan said. That includes two benchmark-sized sovereign dollar bonds being sold by Qatar on Thursday.
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commonly known as "riesgo país" in Spanish speaking countries
is a weighted capitalization market benchmark that measures the financial returns obtained each day by a selected portfolio of government bonds from emerging countries
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the Latin American economies with the lowest sovereign risk was Uruguay and Chile
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JPMorgan will remove Qatar and Kuwait’s government bonds from its influential Emerging Market bond index
while the United Arab Emirates (UAE) is on course to follow next year
due to rising income levels in the Middle East
whose EMBI indexes are the main global benchmark of EM debt
said it will remove Qatar and Kuwait bonds in equal notional amounts over a six-month period beginning on March 31 and concluding on August 29
The two countries currently have respective weights of 3.2 percent and 0.6 percent in the most widely tracked EMBI Global Diversified index
the bank said the country’s cost of living ratio of 64.4 has exceeded its EM index threshold of 54.4 for two consecutive years
which have a 4.1 percent weight in the EMBI Global Diversified “will no longer be eligible for the EMBI series”
AGBI registered members can access even more of our unique analysis and perspective on business and economics in the Middle East
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Dubai Holding is to list its residential real estate investment trust (REIT), shrugging off local investor scepticism towards the structures and becoming the first initial public offering (IPO) on the Dubai stock exchange this year. The investment conglomerate owned by Sheikh Muhammed bin Rashid Al Maktoum, the emirate’s ruler, said on Monday that it will […]
Saudi hospital and clinic operator Specialized Medical Company (SMC) starts the process of selling shares to the public on Sunday – only the second IPO in the kingdom since Donald Trump rocked global markets a month ago with his April 2 tariff announcement. It would also be the first Saudi hospital group to list its […]
It has been a month since President Trump’s “Liberation Day” and a near tripling in US tariffs on imports to their highest in more than a century, after which global financial markets plunged. Overall, however, Saudi Arabia’s $940 billion Public Investment Fund (PIF) has not come out of it too badly. So far, anyway. On […]
Profit at Dubai Financial Market surged more than 40 percent year on year in the first quarter, driven by the highest trading activity in more than a decade, the company said. Net profit before tax rose to AED135 million ($37 million) in the three months to March 31, compared with AED95.6 million in the same […]
Mubadala Investment Company, Abu Dhabi’s $300 billion sovereign wealth fund, has trimmed its holding in Portuguese telecoms operator NOS SGPS. ATIC Second International Investment, a Mubadala subsidiary, reduced its stake from 5 percent to 3.2 percent, according to a regulatory filing by NOS to the Portuguese Securities Market Commission. No reason was given for the […]
A lack of alternative investment choices has helped to swell domestic demand for Omani sovereign bonds, with the sultanate’s latest issuance significantly oversubscribed. Oman issued OR100 million of bonds on Thursday, the second of 10 rial-denominated bond and sukuk sales planned for 2025. These will range from OR50 million to OR100 million and will total […]
The International Monetary Fund (IMF) will begin the fifth review of Egypt’s $8 billion economic reform programme, with a team scheduled to arrive in Cairo this week, the IMF said in a statement on Monday. The IMF board approved the fourth review on March 11, unlocking a disbursement of $1.2 billion in a 46-month IMF […]
Adnoc Distribution said first-quarter 2025 net profit rose significantly as a result of the highest-ever fuel retail sales in the UAE and Saudi Arabia. Net profit increased 16 percent year on year to AED639 million ($174 million), Adnoc unit said in a statement on Tuesday. The Abu Dhabi-listed fuel and convenience retailer added 20 new […]
Dubai-listed telecom operator Du’s top and bottom lines rose in the first quarter of 2025, driven by an increase in the subscriber base and the UAE’s economic growth. Revenue grew more than 7 percent year on year to AED4 billion ($1 billion) during the quarter ended March 2025. The mobile customer base increased by 6 […]
Kuwait’s economy shrank by around $5.5 billion in 2024 after average oil prices declined by $4 a barrel and it cut output in line with Opec+ production quotas. Kuwait’s GDP shrank in current prices by 3 percent to KD49.1 billion ($162 billion) last year from KD50.8 billion ($167.5 billion) in 2023, according to official data […]
Dubai developer Gulf House Real Estate has launched Olaia Residences, its first luxury development, for sale in the heart of Palm Jumeirah. The upscale residential project is planned to open in 2027 and will consist of one-to-three-bedroom apartments and three-to-five-bedroom duplexes. State-of-the-art amenities will include indoor and rooftop pools, a wellness centre, a mini-golf course […]
Saudi Arabia’s budget deficit rose nearly fourfold in the first quarter of 2025 compared to the same period last year, driven by a sharp drop in oil revenues. The kingdom reported a budget deficit of SAR59 billion ($16 billion) in the quarter ended March 2025 from $3.3 billion a year before. Total revenues fell 10 percent to […]
Egyptian financial technology startup Bokra and Aman Holding have arranged a near $60 million bond to help finance credit to small- and medium-sized enterprises (SMEs) in the country, Aman said. The Cairo-based startup arranged EGP 3 billion ($59 million) worth of shariah-compliant debt in partnership with Egypt’s Aman Project Finance, a unit of Aman Holding. […]
Morocco’s trade deficit widened in the first quarter after a surge in imports, the economy and finance ministry reported. The shortfall grew by nearly a fifth, or 17 percent, to MAD71.6 billion ($7.8 billion) in the three months to March 31, compared with MAD61 billion in the same period last year, ministry data this week […]
Low-cost carrier Flynas will launch a share sale on the local stock exchange this month in the latest in a series of initial public offerings (IPOs) by Saudi companies. The subscription to the will run from May 28 to June 1, 2025, according to the company’s prospectus. The airline, partly owned by billionaire Prince Alwaleed Bin Talal, […]
Goldman Sachs reduced its oil price forecast following decisions by the Organization of the Petroleum Exporting Countries and its allies, Opec+, to accelerate oil output increases, the bank said in a note on Sunday. Goldman now expects Brent crude to average $60 per barrel for the rest of 2025 and $56 per barrel in 2026, […]
Oman and Algeria have signed an agreement to create a joint venture oilfield services company in the North African country, according to local media. The agreement was signed on Monday. Algeria’s state oil operator, Sonatrach, signed the agreement with Abraj Energy Services, a wholly owned subsidiary of Oman’s global integrated energy group OQ, during sultan of […]
Oman has toughened rules around licensing new petrol stations, telling operators to install solar power and provide electric vehicle charging points and other facilities. The Ministry of Commerce, Industry and Investment Promotion has said it will not issue licences for new petrol pumps unless they fulfil requirements which include the provision of fuel, suitable pumps […]
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Volume 7 - 2022 | https://doi.org/10.3389/feduc.2022.957199
Blended learning is gaining popularity because it has shown to be a successful method for accommodating an increasingly varied student body while enhancing the learning environment by incorporating online teaching materials
Higher education research on blended learning contributes to the blended learning literature
The ideas for future researchers are a vital component of research-based research articles
This study aims to consolidate the recommendations made for future studies
Research articles published in Scope-indexed journals over the past 5 years were analyzed in this context
Each cited passage from the research was read and coded independently in this analysis
the codes were merged into categories and themes
direct citations were used to support the codes
The number of publications increased starting in 2017 and continuing through 2020
Approximately half of the publications provide recommendations for future research
The researchers’ recommendations were gathered under the titles “Research Content” and “Replication and Method” the researchers’ recommendations were gathered
He concluded that the word is most frequently used to refer to the practice of combining traditional face-to-face education with online learning
It has been voiced in different studies (Cortez, 2020; de Brito Lima et al., 2021) that there is a “new normal” in many educational institutions and disciplines after COVID-19 and that blended learning approach has gained serious popularity in this context
Blended learning preserves student-teacher connection and peer learning. Still, it also can be more adaptable because students may access a portion of their coursework online and the amount of time they need to spend in the classroom can be reduced (Phillips et al., 2016)
No study was discovered in examining the literature that investigated the suggestion for future research portions of the studies on the subject of blended learning
the previous research section could not be mentioned in the study
This work will contribute significantly in terms of offering a collective suggestion to future scholars on the subject of blended learning
it contributes to the research methodology by restating in broad terms the significance of the content of “recommendations for future researchers.”
the purpose of this study was to investigate the recommendations made for further research in the publications that have been published during the past 5 years on blended learning in higher education
This study may be categorized as a qualitative study since it is based on qualitative data analysis on data that was already published in other studies
As a result of the fact that the bibliometric information for the publications received throughout the study is also investigated
this information may also be assessed as part of the bibliometric study
Scopus, one of the most widely used databases, was chosen to collect data. Scopus aids the research workflow’s efficacy and efficiency (Why choose Scopus - Scopus benefits | Elsevier solutions, 2018)
Scopus was selected as the database of choice since it indexes the top journals in the field of education and offers the necessary data for bibliometric research
“Blended Learning” and “Higher Education” were used as the study’s search keys
the last 5 (2017–2021) years and the conditions of being a published article were added
Since the publications will be included in the content analysis
the restriction that the broadcast language is English has been added
The obtained data were downloaded in CVS format for analysis
the selection and elimination process of the publications has been started
The 1958 article was primarily examined for duplication
Nine articles that did not meet the requirement were excluded from the study
The titles and abstracts of the 1949 article were reviewed
Studies that did not meet the following conditions were excluded from the scope
(2) no theoretical work or conceptual paper
(3) No meta-analysis and meta-synthesis work
(5) Not focusing only on distance education or face-to-face education
1406 publications were excluded from the scope of the studies
the full texts of the studies were reached
Content analysis of the study was carried out
and it was examined in detail whether it complied with the above conditions
There are 318 publications left for content analysis
The articles retrieved as a consequence of scanning through the database were investigated in-depth
and it was determined whether or not they fulfilled the requirements of the research objective
the first thing that is done is to determine whether or not there is a distinct area for “recommendations for future studies.” It has been pointed out that articles on this topic often include headings like “the limitations of the study,” “Limitations,” “Recommendations” and “Research Implications.” Then we check that there is any recommendation for future researchers
and recommendations for future researchers were cited
Two authors are responsible for controlling all articles separately and determining excerpt-related sections
Then all teams read independently and coded each excerpt
the codes were refined until a consensus about their use could be reached
Then the codes were merged to form categories and themes
direct quotations were included to support the Codes
statistical information about the publications was first shared
and then the findings obtained from the content analysis were shared
There was a rise in the number of publications beginning in 2017 and continuing through 2020 (Figure 2)
The year 2020 saw the greatest number of publications
it is still significantly greater than in previous years
It is possible that the mandatory implementation of blended and remote learning procedures as a result of the pandemic caused the surge that occurred in the years 2020 and 2021
The second rank is “Internet and Higher Education.” Based on the number of articles
the first rank is “Education and Information Technologies” and the second order is “BMC Medical Education” with ten articles
The last rank is “SAGE Open” with four articles and 53 citations
Due to the technology dimension in blended learning
journals related to technology and the internet have naturally come to the fore
Compare the article’s number and total citation based on journal
When the papers with the highest citations were analyzed (Table 1), they were connected to the flipped classroom concept, which falls under the umbrella of blended learning. Although it was released later than the other nine studies, the one by Han and Ellis (2019) made it onto the list of the top ten
There are several research approaches and methodologies
Studies that follow participants over time are known as longitudinal studies
Other types of studies include qualitative and experimental research
When the studies are analyzed (Figure 4)
it is found that 66 of the studies have a distinct part labeled “recommendations” “Future research” or “the limitations of the study” in which recommendations and proposals for more research might be made
43 of the papers feature additional parts that contain recommendations for the continued study of blended learning
The word “suggestions” was used as the heading for 23 different articles that offered advice to professional practitioners
111 of the 251 papers that did not have a distinct title for their suggestions had textual advice for future study
These recommendations were written in the articles
These recommendations were often provided in the form of a distinct paragraph inside the “result” section; however
they were voiced within the discussion sections of the respective articles
There was no future study suggestion on blended learning in any of the remaining 140 of the 251 publications
Connection separate section and recommendations for future studies
When we classify according to the fields of the studies examined
53 studies are composed of non-specific studies
Thirty-one studies are related to the STEM field covering physics
Considering the 21 studies in the field of health education together
the STEM field has the highest rate with a total of 52 studies
Language education comes next with 31 studies
The other 18 studies were conducted in social science
Content analysis was performed in the “future research proposals” section. These recommendations fall into two main categories (Figure 5)
The codes in the first category are “Other data collection tools,” “Arranging other activities” and “Focusing on components.”
The authors recommended collecting data from other data sources during the research process
The researcher may have offered such suggestions because they had difficulties collecting in their context or because they needed different data to enrich the process
Other Data Collection Tools code is used for 80 studies
In the study conducted by Gjestvang et al. (2021)
interviews were done with the participants during the data collection process
they stated that “Further research on this topic should interview blended learning students at the end of the program” in the recommendations
The inclusion of such data collection aspects will also differentiate the research process
The second code is “arranging other activities”: this code includes suggestions for differentiating the activities done in the learning process. It is coded in 19 articles. For example, “future research can focus on investigating student engagement in learning scenarios aimed at presenting new content rather than being limited to revision lessons (de Brito Lima et al., 2021).” As stated
it is recommended that future studies produce new content
The quote in the study is as follows: “It is hoped that future researchers will be able to improve the ability of online learning management systems they can better implement blended PBL.”
The replication category contains suggestions to repeat the research under certain conditions
The authors generally support conducting studies that are somewhat similar to the investigation
“Other disciplines,” “Implementing other courses,” “Diverse sample,” “Other participants” and “Larger sample” stand out
“Deep analyzes” and “Long term effect” branches were evaluated in replications and methodology categories
a sample was taken to cover the whole University
The authors recommended more specific studies involving different disciplines
The authors offer their suggestions: “In future research with executive education
comparing different professional areas and program content (finance
and management) should be considered since those variables could modify the relationship to adopt new technologies in executive education.”
The author used the phrase “Future research can explore other dimensions in different theoretical and practical courses
and societies.” for this suggestion
The “Other participants” code suggests that the authors should collect data from different participants in future studies. This code was used in 8 studies. In the study conducted by Manzanares et al. (2017)
and he suggested that teachers be included in future studies
and student-system interactions have been analyzed
student-student and teacher-system relations will be studied to analyze whether these behavioral patterns influence the results of student learning and can predict the detection of at-risk students.” It was also stated that other data sources would be needed
Similarly, in the study by Zimba et al. (2021)
collecting data from students and administrators was suggested
“We recommend that a comparative study be conducted with social work educators in distance-teaching institutions since all participants in this study were from contact teaching institutions
We also recommend more research on BL that includes the voice of the students and university administrators.”
the study could be extended to investigate these issues in other students
as the participants of this study were nursing students.” work is recommended
The authors expressed this: “Further research could investigate more deeply the actual meanings of these terms through focus groups with both faculty and administrators.”
the expression “we recommend future research to investigate long-term effects of bPBL” was used
“There can be a comparative study of different formats of blended learning.”
“Future studies may also consider conducting a longitudinal study to increase the ability to make causal inferences related to the students’ use of LMS.”
A pre-test and post-test design can also help examine differences in improvements in SRL and sewing techniques before and after using online modules.” suggests replicating the study by changing the method
But researchers care about working with a larger sample
The “larger sample” code was used the most in the codes related to sampling
“Comparative Studies” “Cross-Cultural Studies” “Longitudinal Studies” and “Changing methodology” are all sections of the methodology category. In blended learning implementations, there is a wide range of methodologies such as quantitative approach (Han and Ellis, 2019), experimental method (Hijazi and AlNatour, 2020), and qualitative approach (Taylor et al., 2018)
the authors believe that their study may be applied to various situations and methodologies
it is discovered that 66 of them have a section labeled “recommendations” “Future research” or “the limitations of the study.” In addition
43 of the papers have sections with research recommendations
There were textual recommendations for future research in 111 of the 251 publications that did not have a label for their ideas
The STEM field has the highest rate in selected studies
“Other Data Collection Tools” is the most coded category under “Research Content.” Diversification of data sources is important to researchers
The Replication category has two codes for the transfer of work to other domains: “Other disciplines” and “Implementing other courses.” The Replication category’s “Larger sample” “Diverse sample” and “Other participants” branches all deal with sample size
The study strategy determines whether the sample size is large or small
The “larger sample” code was the most common among the sampling-related codes
In both the replication and procedure categories
we accepted the codes “Deep analyzes” and “Long term effect” The category “Comparative Studies” includes subsections such as “Cross-Cultural Studies
“ “Changing methodology” and “Methodology.”
Only publications from journals indexed in the Scopus database were included in the study
which is one of the study’s limitations
In the course of the investigation of the recommendations made in the research
content analysis was performed on the statements made by the authors
There has been no investigation into whether or not the intended published research scope is appropriate
The “Recommendations for future research” section might be examined for its level of quality by researchers in the future
It is possible to determine whether the codes produced by investigations of the same kind in several fields are field-independent
our investigation was limited to papers based on previous research
The breadth of data sources may be enlarged without more limits being added
as the focus of future research will be on theoretical investigations
it will be of use to researchers in that it will remind them of the significance of “recommendations for future research”
and SD contributed to conception and design of the study
SD and SBD searching database and analysis
RP and NK wrote the first draft of the manuscript
All authors contributed to manuscript revision
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations
Any product that may be evaluated in this article
or claim that may be made by its manufacturer
is not guaranteed or endorsed by the publisher
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this report was posted online as an MMWR Early Release
Studies suggest that immunocompromised persons who receive COVID-19 vaccination might not develop high neutralizing antibody titers or be as protected against severe COVID-19 outcomes as are immunocompetent persons
Effectiveness of mRNA vaccination against laboratory-confirmed COVID-19–associated hospitalization was lower (77%) among immunocompromised adults than among immunocompetent adults (90%)
Vaccine effectiveness varied considerably among immunocompromised patient subgroups
What are the implications for public health practice
Immunocompromised persons benefit from COVID-19 mRNA vaccination but are less protected from severe COVID-19 outcomes than are immunocompetent persons
Immunocompromised persons receiving mRNA COVID-19 vaccines should receive 3 doses and a booster
be monitored closely and considered early for proven therapies that can prevent severe outcomes
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defined as those with suppressed humoral or cellular immunity resulting from health conditions or medications
Immunocompromised adults are at increased risk for severe COVID-19 outcomes (2) and might not acquire the same level of protection from COVID-19 mRNA vaccines as do immunocompetent adults (3,4)
To evaluate vaccine effectiveness (VE) among immunocompromised adults
data from the VISION Network* on hospitalizations among persons aged ≥18 years with COVID-19–like illness from 187 hospitals in nine states during January 17–September 5
Using selected discharge diagnoses,† VE against COVID-19–associated hospitalization conferred by completing a 2-dose series of an mRNA COVID-19 vaccine ≥14 days before the index hospitalization date§ (i.e.
being fully vaccinated) was evaluated using a test-negative design comparing 20,101 immunocompromised adults (10,564 [53%] of whom were fully vaccinated) and 69,116 immunocompetent adults (29,456 [43%] of whom were fully vaccinated)
VE of 2 doses of mRNA COVID-19 vaccine against COVID-19–associated hospitalization was lower among immunocompromised patients (77%; 95% confidence interval [CI] = 74%–80%) than among immunocompetent patients (90%; 95% CI = 89%–91%)
This difference persisted irrespective of mRNA vaccine product
and timing of hospitalization relative to SARS-CoV-2 (the virus that causes COVID-19) B.1.617.2 (Delta) variant predominance in the state of hospitalization
VE varied across immunocompromising condition subgroups
ranging from 59% (organ or stem cell transplant recipients) to 81% (persons with a rheumatologic or inflammatory disorder)
Immunocompromised persons benefit from mRNA COVID-19 vaccination but are less protected from severe COVID-19 outcomes than are immunocompetent persons
and VE varies among immunocompromised subgroups
health care systems and research centers with integrated medical
and vaccination records that was established to assess the effectiveness of COVID-19 vaccines (6)
Eligible hospitalizations were defined as those among adults aged ≥18 years with SARS-CoV-2 molecular testing (from 14 days before through 72 hours after admission) and a COVID-19–like illness discharge diagnosis.¶ Encounters without molecular testing were excluded from this analysis
Immunocompromised patients were defined by the presence of at least one selected discharge diagnosis for immunocompromising conditions using the International Classification of Diseases
Ninth Revision and International Classification of Diseases
Diagnoses across five categories of immunocompromising conditions were derived from lists used in previous studies of large hospital-based or administrative databases and included the following conditions: 1) solid malignancies
3) rheumatologic or inflammatory disorders
4) other intrinsic immune conditions or immunodeficiencies
and 5) organ or stem cell transplants (7–9)
Immunosuppressive medication use data were not available for these analyses
Vaccination status was documented in electronic health records or state immunization registries (6)
Full vaccination was defined as receipt of the second in a 2-dose series of Moderna (mRNA-1273) or Pfizer-BioNTech (BNT162b2) vaccines ≥14 days before the index hospitalization date; unvaccinated patients had not received any COVID-19 vaccine doses and were considered the referent group
Patients who received 1) only 1 mRNA vaccine dose
3) the second dose <14 days before index hospitalization date
or 4) the Janssen (Johnson & Johnson [Ad26.COV2]) vaccine were excluded from the analysis
VE was estimated using a test-negative design comparing the odds of a positive test result for SARS-CoV-2 between fully vaccinated and unvaccinated patients using multivariable logistic regression models
calendar time (days from January 1 to hospitalization)
and local virus circulation in the community where each partner site was located and weighted for inverse propensity to be vaccinated or unvaccinated (calculated separately for each VE estimate)
Generalized boosted regression trees were used to estimate the propensity to be vaccinated based on sociodemographic characteristics
VE estimates were stratified by immunocompromised status
and network partner (representing different health care systems and geographic regions)
VE was also calculated separately among subgroups of patients with each of the five categories of immunocompromising diagnoses (subgroups that were not mutually exclusive)
VE was also calculated separately for hospitalizations occurring before and after the period when the Delta variant accounted for ≥50% of sequenced isolates within each site’s state (10)
VE estimates with 95% CIs that did not overlap were considered statistically different
This study was reviewed and approved by Westat
Among 69,116 immunocompetent adults and 20,101 immunocompromised adults hospitalized with COVID-19–like illness and with available molecular testing results for SARS-CoV-2, 29,456 (43%) and 10,564 (53%), respectively, were fully vaccinated (Table 1)
The median ages of immunocompetent and immunocompromised patients were 68 years (interquartile range [IQR] = 52–79 years) and 70 years (IQR = 60–78 years)
42% had received the Moderna vaccine and 58% had received the Pfizer-BioNTech vaccine
41% and 59% had received Moderna and Pfizer-BioNTech vaccines
the median interval from receipt of the second vaccine dose to hospital admission was 89 days (IQR = 52–129 days) among Moderna vaccine recipients and 90 days (IQR = 52–131 days) among Pfizer-BioNTech vaccine recipients; among immunocompromised patients
the intervals were 89 days (IQR = 52–128 days) and 89 days (IQR = 53–128 days) for Moderna vaccine and Pfizer-BioNTech vaccine recipients
Among immunocompetent patients, SARS-CoV-2 infection was laboratory-confirmed in 9,853 (24.8%) unvaccinated and 1,108 (3.8%) fully vaccinated persons, compared with 1,127 (11.8%) unvaccinated and 410 (3.9%) fully vaccinated immunocompromised patients (Table 2)
VE of 2 doses of mRNA vaccine against COVID-19 hospitalization was lower among immunocompromised patients (77%) than among immunocompetent patients (90%)
Differences persisted when analyzed among patients aged 18–64 years and aged ≥65 years
and among Moderna and Pfizer-BioNTech vaccine recipients
VE was 81% for the Moderna vaccine and 71% for the Pfizer-BioNTech vaccine; however
CIs slightly overlapped between these two estimates
VE was similarly lower among immunocompromised than among immunocompetent patients both before the period of Delta variant predominance (76%; 95% CI = 69%–81% versus 91%; 95% CI = 90%–93%) and during the period of Delta variant predominance (79%; 95% CI = 74%–83% versus 90%; 95% CI = 89%–91%)
VE point estimates varied more for immunocompromised patients (57–85%) than for immunocompetent patients (84%–94%)
Subgroup VE point estimates were generally higher for the Moderna vaccine than for the Pfizer-BioNTech vaccine but were the same among patients with a rheumatologic or inflammatory disorder
In a multistate analysis of approximately 89,000 hospitalizations of adults with COVID-19–like illness during January 17–September 5
receipt of 2 doses of mRNA COVID-19 vaccine was effective in preventing laboratory-confirmed COVID-19 hospitalizations among patients who were immunocompromised (VE = 77%) and those who were immunocompetent (VE = 90%)
immunocompromised patients were significantly less protected from severe COVID-19 outcomes compared with immunocompetent patients
supporting the recommendation for administration of a third dose of mRNA vaccine to further enhance protection of moderately to severely immunocompromised persons against severe COVID-19 outcomes (5)
This study also found that VE was lower among certain subgroups of immunocompromised adults
such as solid organ or stem cell transplant recipients
These findings are consistent with other studies suggesting that certain immunocompromised persons experience an attenuated immune response to COVID-19 vaccines and make up a large proportion of hospitalizations for infections after vaccination (3,4)
The prevalence of SARS-CoV-2 infection was approximately two times greater among unvaccinated immunocompetent patients compared with unvaccinated immunocompromised patients
Because the study sample was restricted to patients hospitalized with COVID-19–like illness
this difference might be related to a variation in the prevalence of other respiratory virus infections between the two groups
A strength of the test-negative design is that such a difference is not expected to influence the validity of VE estimates stratified by immunocompromised status
The findings in this report are subject to at least six limitations
the use of selected discharge diagnoses as surrogates for presumed immunocompromised status and the absence of medication and other relevant data might have led to classification of persons as immunocompromised who were not; the opposite is also possible but is less likely
selection bias might be possible if vaccination status influences the likelihood of receiving testing although a previous VISION Network study indicated that vaccination status did not affect receipt of testing (6)
despite the high specificity of COVID-19 vaccination status from these data sources
although inverse weights balanced unvaccinated and vaccinated hospitalized patients on sociodemographic and health characteristics
mask-wearing and waning immunity) in this observational study might have biased these estimates
the study only assessed mRNA COVID-19 vaccines and not the Janssen vaccine and included health care systems in only nine states
limiting the potential for the findings of this study to be extrapolated
immunocompromising conditions were not mutually exclusive
and sparse data in smaller immunocompromised subgroups reduced VE precision
so it was not possible to determine the independent effect of each subgroup on VE
Immunocompromised persons benefit from and should receive COVID-19 vaccines
Given that VE is lower compared to immunocompetent patients
immunocompromised persons receiving mRNA vaccines should receive 3 doses and a booster 6 months after the third dose
immunocompromised persons should implement nonpharmaceutical prevention strategies such as masking to help prevent SARS-CoV-2 infection
be monitored closely and considered early for proven therapies that might prevent progression to severe illness (e.g.
Additional studies are needed to further characterize variation in VE among immunocompromised subpopulations and across geographic regions
determine the degree of improvements in VE conferred by additional COVID-19 vaccine doses in immunocompromised populations
evaluate whether different approaches to vaccine administration might improve VE (e.g.
dosage timing or temporarily withholding immunosuppressants)
and further evaluate possible differences in VE between vaccine products
Corresponding author: Peter J. Embi, pembi@regenstrief.org
1Regenstrief Institute
Indiana; 2Indiana University School of Medicine
Oregon; 5CDC COVID-19 Response Team; 6Baylor Scott & White Health
Texas A&M University College of Medicine
Texas; 7Department of Biomedical Informatics
New York; 9Division of Infectious Diseases and Clinical Epidemiology
Colorado; 11Kaiser Permanente Vaccine Study Center
California; 12Center for Biomedical Informatics
Minnesota; 14Fairbanks School of Public Health
All authors have completed and submitted the International Committee of Medical Journal Editors form for disclosure of potential conflicts of interest
Naleway reports institutional support from Pfizer outside the submitted work
Kharbanda reports institutional support through HealthPartners to Children’s Minnesota for VISION
Charlene McEvoy reports institutional support from AstraZeneca for the AZD1222 COVID-19 vaccine trial
Jill Ferdinands reports travel support from Institute for Influenza Epidemiology
Klein reports institutional support from Pfizer for COVID-19 vaccine clinical trials and institutional support from Pfizer
and Protein Sciences (now Sanofi Pasteur) outside the submitted work
Suchitra Rao reports grant support from GlaxoSmithKline and Biofire Diagnostics
No other potential conflicts of interest were disclosed
the VISION Network includes Columbia University Irving Medical Center
New York; HealthPartners Minnesota and Wisconsin; Intermountain Healthcare
Utah; Kaiser Permanente Northern California
† Immunocompromised status was defined as the presence of at least one discharge diagnosis
using diagnosis codes from International Classification of Diseases
Ninth Revision (ICD-9) and International Classification of Diseases
for solid malignancy (ICD-10 codes: C00–C80
hematologic malignancy (ICD-10 codes: C81–C86
rheumatologic or inflammatory disorder (ICD-10 codes: D86
other intrinsic immune condition or immunodeficiency (ICD-10 codes: D27.9
K74.3–K74.6 [except K74.60 and K74.69]
or organ or stem cell transplant (ICD-10 codes: T86 [except T86.82–T86.84
§ Index date was defined as the date of respiratory specimen collection associated with the most recent positive or negative SARS-CoV-2 test result before hospitalization or the hospitalization date if testing only occurred after admission
¶ Hospitalizations with a discharge code consistent with COVID-19–like illness were included
COVID-19–like illness diagnoses included acute respiratory illness (e.g.
or pneumonia) or related signs or symptoms (cough
or diarrhea) using diagnosis codes from ICD-9 and ICD-10
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and was formerly President and Chief Executive Officer for the Regenstrief Institute
and Leonard Betley Professor of Medicine and Biostatistics & Health Data Science at the Indiana University School of Medicine.
"I could not be more enthusiastic about the opportunities that lie ahead for our department and our institution," he said in a message to DBMI
"We are uniquely positioned to continue the groundbreaking and high-impact innovations that will transform healthcare and biomedicine for the benefit of people in our communities and across the world
and I know that together we will make 2022 our most successful year yet!"
Read the VUMC Reporter announcement about his coming to DBMI here (published Sept. 2021). He can be reached at peter.embi@vumc.org.
Making Health Care PersonalOur Vision: The world leader in advancing personalized healthOur Mission: Personalizing the patient experience through our caring spirit and distinctive capabilities
Vanderbilt Health is committed to fostering an environment where everyone has the chance to thrive and is committed to the principles of equal opportunity
WFYI featured a study by Regenstrief Institute and the IU..
Regenstrief envisions a world where better information empowers people to end disease and realize true health
has several regional partners that include IU Health and Eskenazi Health
currently interim chair of the Department of Biomedical Informatics and associate dean for research informatics at the The Ohio State University’s College of Medicine
will join Regenstrief in December of this year
Embi earned his undergraduate degree from the University of Florida and his medical degree from the University of South Florida
He completed his internal medicine residency and chief residency at the Oregon Health & Science University
where he also completed a fellowship and earned a master of science degree in medical informatics and clinical epidemiology
where he completed his medical training with a fellowship in rheumatology and immunology at The Cleveland Clinic
before joining the faculty at the University of Cincinnati
He is recognized internationally for his expertise in clinical and research informatics – the application computer and information sciences to health care and biomedical research
Embi was the founding director of the Center for Health Informatics at the University of Cincinnati Academic Health Center
In addition to his interim chair and associate dean roles
Embi currently serves in a number of roles at Ohio State
he is director of the division of clinical and translational informatics in the Department of Biomedical Informatics
tenured associate professor of biomedical informatics
and chief research information officer at the Ohio State University Wexner Medical Center
Embi has received numerous awards and has been recognized with fellowship in both the American College of Medical Informatics and the American College of Physicians
He currently serves on the Board of Directors of the American Medical Informatics Association
“This is a critical time for health care and biomedical research
in collaboration with our health care partners
is essential to transforming the way we practice,” Dr
“I am very enthusiastic about the impacts we can have on the health of our patients and communities
and I am honored by the opportunity to lead the Regenstrief Institute into the future.”
“I am excited about the possibilities that lie ahead for Regenstrief Institute as Dr
Embi assumes the role of president and CEO
I believe Peter’s leadership style and vision are the fuel needed to ignite the change needed for our future
which will further secure our preeminent status in the health informatics community,” said Thane Peterson
executive operating officer of Regenstrief Institute
Embi’s expertise and leadership experience will be key as we develop projects and recruit investigators for the Precision Health Initiative,” said Anantha Shekhar
executive associate dean for research affairs and director of the Indiana Clinical and Translational Sciences Institute
funded by IU’s Grand Challenges Initiative
will develop the school’s expertise in precision medicine
In addition to his leadership position at Regenstrief
Embi will hold the positions of associate dean for informatics and health services research and professor of medicine at the IU School of Medicine
associate director for informatics at the Indiana Clinical and Translational Sciences Institute and vice president for learning health systems at Indiana University Health
He will also be named the Sam Regenstrief Professor of Informatics and Health Services
Embi succeeds former Regenstrief president and CEO William Tierney
now chair of population health for the Dell Medical School at The University of Texas at Austin
Get the latest Regenstrief news and events
Regenstrief Institute authors: Katie Ross-Driscoll
INDIANAPOLIS – A research letter published in the New England Journal of Medicine calls for careful consideration of the
Regenstrief Institute hosted a one-day conference focused on advancing public health data modernization
drawing professionals from across the public
Regenstrief Institute author: Rachel Patzer
Bet the first to know about Regenstrief news and events
It will soon be my second anniversary as the president and chief executive officer of Regenstrief Institute
Anniversaries are good opportunities to review our past and talk about the future
One of the aspects I find interesting is how similar this part of our institute’s journey is to that of our founder and namesake
successful Hoosier businessman and innovator
and engaged in a variety of “re-” projects — re-tooling
All were needed to grow and position his company for greater success
his work mirrors some of the work we are engaged in to launch new initiatives that build upon the strong foundation of the institute and take it in new and exciting directions
The other interesting parallel is the number three
Sam had to take the three separate buildings that had previously fabricated other products and convert them to the dishwasher manufacturing process
transitioning them under one roof to improve workflow
After addressing a few components of the institute’s progress
the institute has three centers — health services research
One of the primary goals over the past two years has been to operationalize and better integrate the three centers
recognizing we can accomplish more as one — One Regenstrief
A big push in this initiative is expanding the resources available to faculty and creating and implementing a process to better recruit
A continuation is to harness the impressive achievements of the institute
including bringing innovations and discoveries to health care settings for the most strategic and viable impact
A key component is the hiring of three vice presidents — faculty development
The VP for faculty development hire has been completed. We are fortunate to have a proven leader, Dr. Aaron Carroll, join our leadership. Here is the announcement: https://www.regenstrief.org/article/carroll-named-vp-faculty-development/
including the VP for business development and the VP for research
are moving along and will add to our capabilities
the VP for research position will create and enable programs that foster the expansion of high-quality research activities across the enterprise and grow the institute’s funded research portfolio
It’s an integral component to continue and expand Regenstrief’s resources and excellence
We want the institute to be able to improve health across any cohort
or disease while seamlessly applying our research strengths in informatics
aging research and our newest focus in implementation science
we aim to positively influence the health care system through improved ideation
and implementation of evidence-based solutions
The institute continues its engagement in many pertinent issues
including the opioid crisis here in Indiana and across the nation
Sam’s and Regenstrief Institute’s Solutions
Sam realized that a new location was unaffordable and inefficient
It was also not an option to shut down production while a new plant was being built on the current site
So what was Sam’s solution to combine the three separate buildings that needed to come under one roof and provide room for future growth
He collaborated with an architect to build a single structure over the existing three buildings
continued the manufacturing process during construction
then tore down the now interior buildings without slowing production
with all employees working together in a better environment
Sam’s solution was our solution; a metaphorical predecessor to our own One Regenstrief initiative
The overarching goal is to provide our highly valued and expert Regenstrief staff and research scientists with support for additional agility
cross-functional atmosphere required for today’s work environment
that means continuing to develop leadership
and continuing to pursue opportunities for growth
we will help strengthen the institute’s future while positively impacting health care with the audacious goal of eliminating disease and helping people everywhere realize true health
We are building on the strengths of our past as we look to having even more impact in the future
Editor’s Note: Regenstrief Institute has a growing number of important relationships with industry and corporate partners
this column will be the first of two (at least) that will highlight these associations
The second column is planned for Wednesday
Medical research that impacts the health of individuals and communities — locally
and ensuring that the findings of that research are disseminated and implemented is essential
asking and answering the important questions as well as ensuring that research findings have the greatest impact often requires perspectives and expertise from multiple sectors with diverse viewpoints
It is for those reasons that Regenstrief has been and continues to grow its engagement and partnerships with selected industries and corporate organizations
There are many such activities ongoing across the Institute
The following are a few exciting examples where Regenstrief Institute has developed academic-corporate partnerships to advance health and healthcare
Since 2012, Regenstrief scientists, data experts and Institute staff have had a strong collaboration with Merck
one of the largest pharmaceutical companies in the world
We have worked side by side with Merck teams on a range of projects that leverage the expertise and data assets under Regenstrief’s stewardship to study diseases and test healthcare interventions
Regenstrief and Merck share a commitment to improving the health of patients through data analytics
education and research that supports evidence-based health care
To that end, the Regenstrief collaboration with Merck has been a model partnership, where topics are proposed and selected by either organization, and research is conducted. Often, the research involves the use of a valuable dataset that Regenstrief stewards on behalf of the Indiana Network for Patient Care (INPC), in collaboration with the Indiana Health Information Exchange
that reflects decades of real-life medical practice and patient behavior representing a wide and diverse range of backgrounds
the partnership has yielded dozens of peer-reviewed papers
many of the results have been disseminated and implemented to improve health
Shaun Grannis
director of our Center for Biomedical Informatics
appreciates the benefits of the collaboration
… Learning the perspectives and collaborating with Merck scientists have enabled us to pursue research in a way we haven’t done before
It’s helped inform the tools that have been created
Merck has been willing to take risks with us
and that is what has made this relationship work
we have a platform that we see being used to advance the art and science of data science that we believe will lead to real-world innovations to improve health care.”
Dr. Grannis, Paul Dexter, M.D., Mike Weiner, M.D., MPH, Jarod Baker
and I sit on the Regenstrief-Merck collaboration steering committee as we and our Merck colleagues look to a future in which we see the innovations we’re contemplating and studying making a real-world impact
Stay tuned for more news on this ongoing initiative
IndRO excels at managing collaborative scientific research partnerships as it provides innovative data analytics
and the expertise of faculty and research staff who are national leaders in their fields
unbiased research that meets both the needs of the business sponsor and Regenstrief’s mission of creating pathways for better health
Regenstrief researchers and staff are doing a great deal of important work to enable discovery and innovation to improve health
and they are doing so in collaboration with myriad organizations
Our industry partners are helping us to advance research by leveraging our collective expertise and resources
Collaborating with industry partners has the potential to help enhance and grow the success and impact of our research and innovation missions
we at Regenstrief continue to eagerly join forces with a variety of partner organizations to actively address the health and healthcare issues of today and the future
Regenstrief Institute continues to bring a wide spectrum of leadership
innovation and talent to the annual AMIA conference
but also to AMIA as an organization and to the global IT community
Considered by many to be the premier biomedical and health informatics organization in the world
AMIA – the American Medical Informatics Association – provides a place where informatics professionals
explore and collaborate to solve some of the most pressing issues facing health and biomedicine
At the most recent AMIA annual symposium earlier this month in San Francisco
our Regenstrief team again brought its “A-Game.”
Organizational Leadership: Of the officers on the board of directors
Regenstrief investigators occupy three of the four positions
to the quality of the researchers and staff who form the Regenstrief family
As proud as I am to serve as chair of AMIA’s board of directors
I’m even more proud to have as my co-leaders such accomplished colleagues as Titus Schleyer
Scientific Leadership: Beyond our role as leaders of the organization
our team has continued to present some of the most groundbreaking work at the symposium
more than two dozen Regenstrief and partner researchers presented at the symposium
Partners included Indiana University School of Medicine and Indiana University Richard M
Fairbanks School of Public Health at IUPUI
This representation is a testament to the amazing work of our numerous investigators from across the Institute and the great leadership by Shaun Grannis and his team in CBMI
an app created by the team from Regenstrief and IU Fairbanks School of Public Health
won first place in the AMIA Pitch IT competition
The app uses social determinants of health to identify patients in need of wraparound services
The team was led by Regenstrief scientist and IU Fairbanks School of Public Health’s Center for Health Policy Director Josh Vest
and new research scientist Suranga Kasthurirathne
from Regenstrief who also is professor and chair of the Department of Health Policy and Management
IU Fairbanks School of Public Health; and Paul Halverson
This is the second year in a row that a Regenstrief-associated project won the competition
conceived of and led a FHIR® application showcase
AMIA and Health Level-7 International partnered for the fast-paced presentations
Presentations included MITRE Corporation’s Pain Management Summary: A SMART on FHIR Dashboard for Managing Pain and Emory University’s DeepAISE on FHIR — an Interoperable Real-Time Predictive Analytic Platform for Early Prediction of Sepsis
Talent: Beyond the annual symposium and board participation
Regenstrief is a true collaborator with AMIA year round
providing crucial support for the continuation of AMIA’s leading edge work
Regenstrief is an AMIA Academic Forum member
We and other communities provide a framework for education
and enable access to strategic information
gatherings and opportunities with online collaborative groups to advance knowledge
I’m very proud of Regenstrief and its relationship with AMIA
providing outstanding intellectual talent and expertise to develop
educate and disseminate innovation in informatics to support improving human health around the globe
AMIA is just one of the many professional societies in which our talented Regenstrief investigators participate
I look forward to highlighting similar great accomplishments and service by our investigators across the range of Centers and programs at our great Institute
the year has been more constructive for capital flows to emerging markets (EM)
This has been predicated by the global easing cycle led by the US Federal Reserve (Fed) and the European Central Bank (ECB) as well as the massive policy stimulus announced by Beijing in September
these supportive conditions emerged after several quarters of a more difficult environment following the aggressive monetary tightening that took place in major advanced economies in 2022
The more positive global macro backdrop is pushing capital towards EM
According to the Institute of International Finance (IIF)
which represent allocations from foreign investors into local public assets
experienced a significant shift from negative territory to positive in late 2023
Such inflows led to a rally that is reflected in robust returns across different EM asset classes since their bottom in October 2023
including gains of 20.2% for equities (MSCI EM) and 19.6% for bonds (J.P
there is scope for further acceleration of capital flows to EM
despite potential shocks coming from trade conflicts and economic policy weaponization
Three main factors sustain the outlook for higher capital inflows into EM: the ongoing policy easing by major central banks
the positive change in major drivers from China and the overall improvement of EM macroeconomic imbalances
changes in interest rates across advanced economies are set to favour investments into EM
as the easing cycle from major central banks deepens over the next few quarters
the US Fed is expected to cut policy rates by 75 basis points (bps) next year
whereas the ECB is likely to cut rates by 100 bps during the same period
interest rates are a major driver of capital flows
with investors seeking to allocate their resources to assets with high
a reduction of benchmark nominal yields in US and Europe drives investors to be more prone to allocating to riskier investments
the decision from Chinese economic authorities to take more comprehensive action to support growth and local asset markets is expected to be a continued tailwind for capital flows into EM for the next several quarters
This is key to drive further capital inflows into EM as China is by far the largest country component of major EM indices
After a massive stimulus encompassing fiscal
the Chinese government provided additional guidance that it is willing to further deploy more measures should it be needed for growth and financial stability
This is expected to revive the “animal spirits” of domestic Chinese investors and attract foreign investors that are underexposed to Chinese equity and fixed income markets
macroeconomic fundamentals are currently stronger in most EM
Several advanced economies have accumulated acute imbalances from excessive policy stimulus following the pandemic and the Russo-Ukrainian conflict
leading to issues such as high public debt and unstable inflation
most EM countries have been conservative with their fiscal policy space
in order to prevent too much debt accumulation or increasing external vulnerability
several EM countries have gained policy credibility
which increases the attractiveness of their markets
after a period of subdued capital inflows into EM
the more positive global macro outlook should provide some support for an acceleration of flows
This is expected to be driven by continuous policy easing by the Fed and the ECB
stronger growth in China and more robust domestic conditions in most major EM
will take the reins as president and CEO of the Regenstrief Institute in December
the Institute officials announced on Tuesday
an internationally recognized expert in biomedical informatics
will leave his post as interim chair of the Department of Biomedical Informatics and associate dean for research informatics at Ohio State University’s College of Medicine
Embi is a practicing physician and a researcher
known for his expertise in clinical and research informatics
He succeeds former Regenstrief President and CEO William Tierney
who now serves as chair of population health for the Dell Medical School at The University of Texas at Austin
[See also: Regenstrief CEO begins new chapter .]
Embi serves in a number of roles at Ohio State
He's director of the division of clinical and translational informatics in the Department of Biomedical Informatics
internal medicine and public health and chief research information officer at the Ohio State University Wexner Medical Center
“This is a critical time for healthcare and biomedical research
in collaboration with our healthcare partners
is essential to transforming the way we practice,” Embi said
“I am very enthusiastic about the impacts we can have on the health of our patients and communities.”
Regenstrief is a global leader in biomedical informatics
health services and aging in innovations and research to improve health and healthcare
It's a supporting organization of the Indiana University School of Medicine and has several regional partners
the Regenstrief Institute and its researchers have been responsible for major developments and studies demonstrating the use of electronic health records and related information technologies to improve the quality and efficiency of healthcare
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Regenstrief has a strong reputation in informatics research. Tell me a little more about its history and some things that drew you to your new position there?
Embi: Regenstrief has been in existence for more than 30 years and is affiliated with Indiana University (IU). Investigators are all faculty at IU, mostly in the school of medicine, but also in public health, informatics and other schools. We have more than 200 employees. The Institute did groundbreaking work in what we now think of as electronic medical record solutions, standards and decision support.
Over the years, we have added to our expertise in the areas of health services research, aging research and implementation science. Now it is a really robust institute with three centers and programs focused fundamentally on how do we improve healthcare by leveraging IT and best practice approaches and evaluation of systems to re-engineer the healthcare enterprise to keep people healthier. It was an opportunity was one I couldn’t pass up.
Your predecessor, Bill Tierney, M.D., left to become chair of population health for the Dell Medical School at The University of Texas at Austin? Those are big shoes to fill, aren’t they?
Is a big part of your job deciding where to focus resources? Are there areas of research that are becoming more important such as precision medicine or genomics?
We have interviewed Regenstrief’s Brian Dixon about leveraging the HIE to enable secondary use of clinical and administrative data to improve public health surveillance.
You mentioned that Indiana has had a strong statewide HIE for many years. Is there a strong culture of collaboration about health IT in Indiana that you don’t see in other states or did they just get started earlier?
Hasn’t Regenstrief been involved in global health and the dissemination of EHRs in developing countries?
As if you were not busy enough already, you were also named chair-elect of the board of directors of AMIA. What are some things you want to work on in that role?
Has anything surprised you in your first few weeks on the job?
2022 at 8:21 PM ESTBookmarkSaveLock This article is for subscribers only.JPMorgan Chase & Co
said it will remove Russian bonds from all of its widely-tracked indexes
Bloomberg LP and other benchmark providers in withdrawing the nation’s assets from key gauges
Russia’s debt will be excluded from the JPMorgan Emerging Market Bond Index
the Government Bond Index-Emerging Markets
the Corporate Emerging Markets Bond Index and all of the bank’s other benchmarks
2019 at 5:18 PM ESTBookmarkSaveLock This article is for subscribers only.Venezuelan government debt may be entirely removed from JPMorgan Chase & Co.’s flagship emerging-market bond indexes after U.S
sanctions effectively wiped out trading in the securities
according to two people familiar with the matter
2017 at 3:36 PM EDTBookmarkSaveLock This article is for subscribers only.Harvard University economist Ricardo Hausmann is calling on JPMorgan Chase & Co
to remove Venezuela from its bond indexes so that investors whose portfolios track the gauges aren’t compelled to buy notes issued by a government accused of human-rights violations
While Venezuelan securities make up only about five percent of the benchmark JPMorgan EMBI Plus index, they account for about 20 percent of its yield because of the country’s high interest rates, Hausmann wrote in an editorial published Friday in Project Syndicate
That means many fund managers feel the need to hold the debt -- even if they think it’s distasteful -- because they’ll be evaluated by how their portfolios perform relative to the index
Venezuelan notes returned 53 percent in the past year
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Egypt joined the JP Morgan Emerging Market Bond Index (EMBI) Monday to become the second country in the Middle East and Africa to be listed in the index
A press statement published by the government on its official Facebook page stated that with an estimated weight of 1.85 percent
Egypt is expected to enter the index with 14 bonds valued at $26 billion
Finance Minister Mohamed Maait said that the Ministry has sought to enable Egypt to rejoin the EMBI for three years after the country had been removed from the index in June 2011 for not meeting requirements
The Minister said Egypt had fulfilled the bank's requirements to rejoin the index
including extending the life of government debt
and promoting foreign investors' participation in government financial instruments
Maait indicated that Egypt's accession to the JP Morgan government bond index for emerging markets is a new certificate of confidence from foreign investors in the solidity of the Egyptian economy
The Minister explained that this confirms that 90 percent of the surveyed foreign investors supported Egypt's entry into the index
The step reflects the continuous efforts of the Ministry of Finance to reduce the cost of public debt as part of the package of measures taken by the state for economic reforms
said Egypt would join the JP Morgan Environmental and Governance Index based on the launch of green bonds in October 2020
Egypt's percentage in this index is 1.18 percent
reflecting the country's presence on the map of sustainable economies and the country's orientation towards green debt tools
Deputy Minister of Finance for Financial Policies and Institutional Development Ahmed Kojak stated that Egypt's inclusion in the indicator translates the efforts of the Ministry of Finance and would contribute to achieving one of the Egyptian government's debt management strategy objectives
It also helps activate the stock market to increase its levels of liquidity and enhance the demand for government debt instruments
which would reduce its cost through the decline in the return required by investors
Kajok expects Egypt to issue international bonds worth $5 billion in the 2022-2023 fiscal year
Oil gained more than $1 per barrel on Tuesday
rebounding on technical factors and bargain hunting after a decision by OPEC+ to boost output sent prices down the previous session
although concerns about the market surplus outlook persisted
Brent crude futures rose $1.15 to $61.38 a barrel by 0623 GMT
the first time gain after six consecutive declines
while US West Texas Intermediate crude added $1.11 to $58.24 a barrel
Both benchmarks had settled at their lowest since February 2021 on Monday
driven by an OPEC+ decision over the weekend to further speed up oil production hikes for a second consecutive month
"Today’s slight rebound in oil prices appears more technical than fundamental," said Yeap Jun Rong
"Persistent headwinds including a pivotal shift in OPEC+ production strategy
and price forecast downgrades are continuing to weigh on the broader price movement."
Driven by expectations that production will exceed consumption
oil has lost over 10% in six straight sessions and dipped over 20% since April when US President Donald Trump's tariff shocks prompted increased bets on a slowdown in the global economy
The return of Chinese market participants after a five-day public holiday since May 1 was seen supporting prices on Tuesday
buyers would have likely jumped to secure oil at current low levels," said Priyanka Sachdeva
Also lending some support was data showing a pick-up in services sector's growth in the US
The Institute for Supply Management (ISM) said on Monday its nonmanufacturing purchasing managers index (PMI) increased to 51.6 last month from 50.8 in March
Economists polled by Reuters had forecast the services PMI dipping to 50.2
The US Federal Reserve will likely leave interest rates unchanged on Wednesday as tariffs roil the economic outlook
Barclays lowered its Brent crude forecast on Monday by $4 to $70 a barrel for 2025 and set its 2026 estimate at $62 a barrel
citing "a rocky road ahead for fundamentals" amid escalating trade tensions and OPEC+'s pivot in its production strategy
Goldman Sachs also lowered its oil price forecast on Monday by $2-3 per barrel
as they now expect another 400,000 barrels per day production increase by OPEC+ in July