Atwater Village taco and burrito window Tacos Villa Corona is opening a second location in Eagle Rock. This is the first expansion in the restaurant’s more than three-decade history; the new location was announced in an Instagram post that estimated an opening in five to six months The original location of Tacos Villa Corona has been open since 1993 and burritos out of its window on Glendale Boulevard The restaurant is best known for its breakfast burritos which come stuffed with a base of potatoes or chilaquiles Today, January 29, sponsors including OpenTable, Delicato Family Wines, Rich Products, and ChowNow are coming together to donate money to Restaurants Care to support restaurants as part of “The Great Los Angeles Dine Out.” For every post on Instagram or X using #TheGreatLosAngelesDineOut hashtag Xi’an noodle specialist Bang Bang Noodles has reopened a location in Downtown LA The tight menu offers a Xi’an tomato dry noodle KQED Live EventsPRX Podcast Garage EventsEvents Around the Bay AreaMember Benefits with KQED LiveVideos from KQED LiveWatch recordings of recent KQED Live events FeaturedThat's My WordAn ongoing exploration of Bay Area hip-hop history See Senior Director of TV Programming Meredith Speight’s recommendations from this month’s KQED 9 Watch recordings of recent KQED Live events Support KQED by using your donor-advised fund to make a charitable gift Check, Please! Bay Area, season 19, episode 10, airs Thursday, November 14, at 7:30 pm, on KQED 9. See other television airtimes we kick things off in Larkspur at World Green Açaí Bowl & Juice a vibrant little spot serving authentic açaí bowls packed with superfoods and other Brazilian favorites guests head to San Francisco’s scenic Presidio to visit Dalida where a former Top Chef contestant serves up contemporary Mediterranean flavors like their 12-hour lamb shoulder tandoor and California tahdig the journey takes us to Napa’s Villa Corona a family-owned gem dishing out delicious Mexican favorites like platos de carne and tacos de pescado in a warm Leslie Sbrocco: Brazilian bites in Larkspur… Mavish Mahomed-Silva: You will never want to have another açaí bowl again Leslie Sbrocco: …contemporary Mediterranean cuisine in San Francisco… Rolando Aguilar: Just a perfect bite with the texture Leslie Sbrocco: …and traditional Mexican fare in Napa… Luciana Duarte: It just goes down way too easy Leslie Sbrocco: …just ahead on “Check Rolando Aguilar and Mavish Mahomed-Silva: Olive pao de queijo Bay Area,” the show where Bay Area residents review and talk about their favorite restaurants and each one recommends one of their favorite spots and the other two go check them out to see what they think Please!” table today are culture transformation consultant Luciana Duarte and partner program manager Mavish Mahomed-Silva Mavish gets us started with her go-to breakfast spot little cafe that packs a big punch when it comes to Brazilian flavors a made-to-order açaí bowl she says is the best in the Bay it’s World Green Açaí Bowl and Juice Laura Rabelo: We try to show for all to Americans to try the real açaí bowls Laura Rabelo: We try to create a space for the people to feel happy the spot that people get together here to hang out here We’re so excited to show all the people our Brazilian foods I love that you say this is your “best in the Bay açaí bowl.” Do you travel the Bay looking for açaí bowls I have had a decent number of açaí bowls at other places You will never want to have another açaí bowl again there’s something about the flavor of their açaí — it tastes pure and you won’t know what I mean until you try it There’s a little bit of sweetness to it but it doesn’t taste like there’s other stuff in it It just — it’s pure açaí It’s just — it’s magic in a bowl Leslie Sbrocco: And the owners are Brazilian Luciana Duarte: How lucky that we got to go to this restaurant And you went and spoke Portuguese to the owners And they actually have terminals for you to order came over and helped make suggestions since it was the first time that we were there Luciana Duarte: So we started with the olive pao de queijo Then we had two different kinds of empanadas which are technically more of an Argentinean specialty we love all kinds of things that are Latin American And so we had one that was filled with chicken They just felt both decadent and light at the same time to the meat was perfect and a perfect flaky crust Leslie Sbrocco: What is it that you get besides the açaí bowl Mavish Mahomed-Silva: My favorite item is their combo breakfast It’s almost like a little buffet on a board and then you get to have either a cheese-bread waffle or a other type of French roll always choosing the cheese-bread waffle 10 out of 10 times And then it’s served with maple syrup or a Brazilian cream cheese that’s a marriage made in heaven in terms of food Rolando Aguilar: So part of the combo breakfast there was a guava juice Luciana Duarte: We did get the açaí juice because they’re so — they’re so thick And so it has kind of that mouthfeel of a smoothie Leslie Sbrocco: Anything else that you can recommend for people to try I would absolutely recommend their tapioca So you get that same kind of chewy texture as the cheese bread and then all of the fillings can be sweet or savory and it’s just like a very hearty meal served with some fruit or salad on the side Luciana Duarte: We didn’t get the breakfast items we did have room for a hot dog and… so the Brazilians have elaborated on the hot dog and this was actually a hot dog with potatoes two ways So it was a base of mashed potato spread on the very flaky and crispy French bread that had been warmed Leslie Sbrocco: And did you have anything else We actually got these delicious little desserts that I had not tried as a Brazilian and they are a peanut-butter two-bite dessert It’s just the perfect amount of savory and sweet you can take them and kind of crumble them on top of your açaí or your juice it seems like you get a lot of food for the price very bang-for-your-buck type of restaurant And something else I noticed was that we were in the patio You start hearing the owner talking with other Brazilians that’s a stamp of approval that local Brazilians are coming to the restaurant so it’s just over the Golden Gate Bridge if you would like to try World Green Açaí it’s located on Magnolia Avenue in Larkspur and the average tab per person is around $25 the cities of San Francisco and Istanbul have a lot in common The menu at Roland’s favorite restaurant is a love letter to both cities as Mediterranean mezes infused with locally foraged California herbs and aromatics forge the perfect blend of east-meets-west Located in San Francisco’s historic Presidio Main Post Laura Ozyilmaz: When people walk into Dalida… We have some… we just want them to feel that they’re welcome Coming from Mexico and Turkey… we’re trying to build something unique with the food and the culture and the hospitality Sayat Ozyilmaz: We call our cuisine Eastern Mediterranean So it’s really centered around this idea of a cosmopolitan Istanbul that celebrated all the cultures Laura Ozyilmaz: People can relate to that in San Francisco because we are a melting pot of cultures Having a restaurant inside the Presidio is just magical We are in the community garden where we pick all our beautiful herbs for Dalida Sayat Ozyilmaz: There’s rose geranium One of my favorite things that I pick from the garden — the nasturtium flowers and then we also serve it with a yogurt made with the leaves really cool to be able to capture the essence of the Presidio and they’re named after me — chubby pitas I think just by having that freshness that comes from the oven to the table in about a minute Sayat Ozyilmaz: One of the things that makes me very happy is It is something that we’ve always been really passionate about and really seeing it manifest itself in the dining room is one of the most rewarding feelings And people actually get frustrated a little bit There’s so many good things on the menu and I cannot experience everything in one visit.” Then come back or is it the location that you really love Rolando Aguilar: It’s definitely two-for-one because the location is beautiful on a sunny It’s Middle Eastern Mediterranean cuisine “What do you recommend?” And the first thing that they said was the breaking bread And it comes out immediately — the fresh it’s just a perfect bite with the texture Mavish Mahomed-Silva: I’m getting hungry now And it’s just the perfect vehicle for all of those dips and spreads there’s more pita on the arayes burger So it’s basically a kebab-stuffed pita with great spices and you see the juices just ooze to the bottom of the pita And you can just have that last tasteful bite and I wish I had ordered the burger now that you’ve described it We actually had a different dish that also had a different kind of pita which are skewers with short rib and sweetbreads which are generally not something that a lot of people love and it kept the skewers warm until we were ready to eat them I was excited to find out that the lamb is halal at this restaurant “I’m ordering the lamb.” So I actually went with one of their pasta-esque dishes And these manti were really tiny and so cute It was served in a red sauce with some sort of yogurt in the middle that balanced out the acidity Rolando Aguilar: We also ordered the 12-hour lamb shoulder tandoor And also you got to have some greens on the dish They have so much precision and just mastered their creativity with the art that they’re presenting which is also something that we enjoy a lot in Brazil Its meat that has been ground and mixed with grains Mavish Mahomed-Silva: I also had the shoestring fries And then it came with a dipping aioli which had a little bit of spice to it It was a nice way to complement the rest of the meal and just And you can kind of see the flavors from the Mediterranean and from Central America Latin America on the dessert menu because you have your tres leches and your rice pudding but you have to go with the traditional baklava But the nice thing about this — it’s deconstructed you have pistachios on top of the puff pastry for the baklava and also adds raspberry cream sauce at the bottom and it’s just drizzled all over the plate so that entire bite was just mesmerizing and hit my sweet tooth very well Luciana Duarte: We had a different dessert and it’s an almond-based cross between a cake and a tart and it comes with a side of honey ice cream and it was just a perfect way to end the meal It had a Turkish coffee whipped cream with some hazelnuts on top Sayat Ozyilmaz: So this is the wild pistachio berries Mavish Mahomed-Silva: So they take pistachios and they treat them like they would a coffee bean and they turn it into almost like a warm nut milk I’ve never had something like that before Dalida has a commitment to an extensive cocktail program and really one of the best wine lists I’ve seen Did you have anything to drink with your meal So we had the pleasure of sitting at the bar because it was impossible to get a reservation we don’t have a reservation.” They said You can sit at the bar.” And that was a stroke of luck because the bartender was fantastic And then we also had a few glasses of wine by the glass and some of them were obscure that we wouldn’t have tried necessarily which is “The Gentleman.” It had tequila And then it comes in a very beautiful goblet that keeps the drink very cold So you can drink like three or four of those and not even notice because it’s so well… Leslie Sbrocco: As long as your girlfriend’s driving Rolando Aguilar: So we were lucky enough when the dessert came Chef Laura Ozyilmaz presented the dessert for us “That’s Chef Laura,” in my mind Leslie Sbrocco: She was also on “Top Chef.” Leslie Sbrocco: It’s better to be on “Check Everything was just like an orchestra conducted beautifully it’s located in the Presidio in San Francisco The average dinner tab per person without drinks is around $85 Leslie Sbrocco: Luciana’s a big fan of under-the-radar Her favorite Mexican eatery is no exception Serving the traditional dishes of Jalisco for more than 50 years Carlos Villaseñor: Villa Corona is a piece of Napa Daniel Villaseñor: It’s comfort food Villa Corona is my parents and my siblings My sister Gabriela — she runs the kitchen Fernando Villaseñor: Butter and garlic Carlos Villaseñor: My younger brother Fernando runs operation of the restaurant here Carlos Villaseñor: So my parents started in 1972 We grew up going to all the vineyards selling burritos My dad would make the burritos at the restaurant and then we’d go out to the vineyards and he’d sell them out of a van The only reason we went to school was because my mom made us Fernando Villaseñor: This is a butter-and-garlic shrimp with the rice and beans Daniel Villaseñor: Our parents wanted to bring some part of Jalisco in our food Carlos Villaseñor: Our shrimp dishes The distinct burrito for us is the wet burrito The sauce is — it’s smothered in our homemade gravy Daniel Villaseñor: My parents did not just make a green sauce They made a chile verde sauce with a lot of ingredients that gave it a lot of taste Carlos Villaseñor: And the red sauce is made from the broth of the chicken that we cook Daniel Villaseñor: Everything’s made daily Carlos Villaseñor: Good ingredients so we don’t have stuff sitting around Daniel Villaseñor: Food doesn’t sit around because it doesn’t last long Carlos Villaseñor: It’s fresh Carlos Villaseñor: We’re still old-school Daniel Villaseñor: The nice thing about our restaurant is the range of people and you would see one of the Mondavis here We have people that have been eating here for 40-plus years what’s unique about this spot is it’s been going for 50 years it really is unpretentious Mexican comfort food is the best way I can describe it My husband and I really enjoy their generous but we also have honed in on a couple of dishes that are our tried-and-true ones And we always get the plato de carne with carne asada and it comes with your choice of corn or flour tortillas which are delicious and fresh and actually a fairly healthy dish because it’s a grilled piece of fish on a bed of lettuce that’s shredded and chopped tomatoes and it comes with a side of the rice and the beans Rolando Aguilar: So I actually got the fish tacos And you can just tell that the fish was grilled immediately right when you ordered it It’s just a fresh bite with pico de gallo and Maria’s enchiladas was a spicy green sauce with tangy crema it felt like my tia’s house with all the decor My grandma and I used to make horchata growing up It’s the perfect drink for a hot day in Napa Luciana Duarte: So they also have these delicious chips and salsa and guac I actually didn’t have the chips and salsa and it had some sort of tomato sauce around it I thought it could have had a little bit more oomph in the flavor but it was a nice first-appetizer type of portion It’s a good option for vegetarians or people who really want to keep it light Mavish Mahomed-Silva: But the star of the show for me were their camarones a la diabla I have to order something with chilies on the menu There were just a lot of nice components on the plate to kind of break up the spiciness on your palate which are essentially popsicles that you can get from a cooler in the back And so they have a takeout counter which is accessed through a side door I went with the traditional Mexican churro and I had that to go because I wanted to eat it on the road because I was too full your traditional Mexican churro with cinnamon sugar and just a good crunch I had one hand on my churro and one hand on the steering wheel But hopefully next time I’ll get the paletas because a nice Mavish Mahomed-Silva: And now I’m feeling some type of way about not having dessert Leslie Sbrocco: And did you feel like you got value I took leftovers home — it was such a massive plate of food — and I had it the next day it’s located in Bel Aire Plaza in Napa and the average lunch tab per person without drinks is around $25 Looking for more Bay Area bites you’ve just got to try Check out “Cecilia Tries It” online at kqed.org/checkplease I have to thank my great guests on this week’s show — Luciana Duarte who’s very fond of the fresh fish tacos at Villa Corona in Napa who loves breaking bread at Dalida in San Francisco who tucks into hearty Brazilian breakfasts at World Green Açaí Bowl and Juice in Larkspur So join us next time when three more guests will recommend their favorite spots right here on “Check Sayat Ozyilmaz: We don’t ever feel like we’re working Sometimes we just look in each other’s eyes and… Daniel Villaseñor: I remember when we were washing dishes I think we broke more dishes than what we washed This is different.” “Is it possible with sugar?” “Yes!” “Wow Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application 1996 and passed away at the age of 28 in his hometown of Denver Eric believed strongly in family values and spent most of his time enjoying the adventures of life with his family Eric created an enjoyable environment wherever he went reading Stephen King novels and comic books He was preceded in death by his grandpa (Poncho Villa-Ortega) Our family appreciates the support of friends and family Thank you for the abundance of prayers and love sent our way Eric was a wonderful human being who was loved by so many people throughout his life He was welcomed into the arms of Jesus on April 5 29 Take my yoke upon you and learn from me 30 For my yoke is easy and my burden is light.” Add to Calendar Horan & McConaty Funeral Service and Cremation - Southwest Denver/Lakewood Complete the form below to RSVP for the Visitation for Eric Aaron Edwards Complete the form below to get directions for the Visitation for Eric Aaron Edwards Add to Calendar Complete the form below to RSVP for the Rosary for Eric Aaron Edwards Complete the form below to get directions for the Rosary for Eric Aaron Edwards Add to Calendar Complete the form below to RSVP for the Mass for Eric Aaron Edwards Complete the form below to get directions for the Mass for Eric Aaron Edwards Add to Calendar Complete the form below to RSVP for the Graveside Service for Eric Aaron Edwards Complete the form below to get directions for the Graveside Service for Eric Aaron Edwards This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors A Rohnert Park food festival and a Napa restaurant are among the number of Bay Area eateries to be featured in KQED's popular restaurant review series in November Maricruz Sanchez is the owner of The Real Chamoy Cecilia Phillips paid a visit to Rohnert Park's Fork’n Good Food Festival to try various foods for an episode of KQED's Check Please with a Flamin’ Hot Cheeto-crusted burger from Santa Rosa's Indian Village Eats Omar Galvan delivers an order from the pickup window at Galvan’s Eatery in Santa Rosa Carne asada fries require a fork at Galvan’s Eatery in Santa Rosa Grilled cheese with birria on Texas Toast is a menu option at Galvan’s Eatery in Santa Rosa Brussels sprouts and a pulled pork sandwich at War Pigs Craft Kitchen in Santa Rosa Dirty Fries at War Pigs Craft Kitchen in Santa Rosa Pulled pork sandwich on a brioche bun at War Pigs Craft Kitchen in Santa Rosa Hot Reuben dip with chips and pretzels from Lila's Streetside Eats food truck A burger from The Wurst restaurant in Healdsburg The Tri-Tip Trolley at the Sonoma Farmers Market KQED’s award-winning “Check, Please! Bay Area” restaurant review series will be back next month with a roundup of new locals’ picks from in and around San Francisco including a Napa restaurant as well as a Rohnert Park food festival Host Leslie Sbrocco and three Bay Area locals discussed favorite eateries during the new season of the four-episode series which airs Thursdays beginning at 7:30 p.m. Sonoma County will once again make an appearance on “Check, Please!” as the show visits Rohnert Park’s Fork’n Good Food Festival in its last episode of the season KQED’s announcement of the episode lineup stated reporter Cecilia Phillips of “Cecilia Tries It” sampled the food festival’s gourmet eats Food included “local Sonoma bites” as well as “globally inspired street food.” Many Bite Club favorites appeared in the food truck lineup, such as Ápí Hot Chicken, War Pigs BBQ (which now has a restaurant on Marlow Road) Lila’s Streetside Eats and Healdsburg’s The Wurst Other county-based food trucks included Moxies Frozen Yogurt For updates on the next Fork’n Good Food Festival, keep an eye on The SoCo Market website, Facebook or Instagram Click through the above gallery to check out the eats you can expect to find at The SoCo Market’s Fork’n Good Food Festival Please!” visits Villa Corona in Napa where the crew samples “delicious Mexican favorites like platos de carne and tacos de pescado.” which also has locations in Vacaville and St The restaurant is known for generous servings friendly service and an artsy atmosphere (catch the Mexican-themed paintings adorning the walls) 3614 Bel Aire Plaza, Napa, 707-257-8685, villacoronanapa.com Lake and McHenry County Scanner Charges have been upgraded and a judge denied pre-trial release to a man accused of driving over three times the legal limit and crashing into a home near Lake Villa was initially charged with reckless homicide Prosecutors have since additionally charged him with aggravated driving under the influence causing death Lake County Sheriff’s Office Deputy Chief Christopher Covelli said the charges stem from a crash into a home around 7:25 p.m on December 24 in the 21300 block of West Engle Drive in unincorporated Lake Villa Sheriff’s deputies arrived and located a Jeep and a home that had sustained major damage was traveling eastbound on West Engle Drive Corona-Vargas’s vehicle crossed into the westbound lane of traffic and then back into the eastbound lane Corona-Vargas drove off the roadway on the south side into a yard and the Jeep crashed into the home The home was unoccupied at the time of the crash who was sitting in the front seat of the Jeep was critically injured and pronounced dead at the scene Covelli said another 22-year-old Round Lake Beach man was seriously injured and transported to an area hospital for treatment Corona-Vargas suffered serious injuries and was transported to an area hospital for treatment Sheriff’s traffic crash investigators determined Corona-Vargas was driving under the influence of alcohol at the time of the crash He was released from the hospital on Tuesday — a week after the crash — into the custody of the Lake County Sheriff’s Office and transported to the Lake County Jail Lake County Assistant State’s Attorney Nicholas Shepherd said beer cans were found inside the Jeep The seriously injured passenger told investigators they had been drinking at a friend’s house and that Corona-Vargas had a lot of beer — approximately five or six Shepherd said Corona-Vargas admitted to driving 50-55 mph in a 30 mph zone after drinking beer He said he lost control of the car and that there was ice on the ground Corona-Vargas’s blood alcohol content was 0.27 He also allegedly had cannabis in his system Corona-Vargas was in a neck brace and a wheelchair when he appeared in court this week said that Corona-Vargas has approximately 14 staples in his head after being released from the hospital and still needs to undergo spinal surgery Ritacca said Corona-Vargas’ family is close with the victim’s family and Corona-Vargas’ family attended a funeral and celebration of life for the victim Ritacca argued for Corona-Vargas’ release pending trial and said that his client is not a danger to the community as he cannot drive due to his injuries very sad and it is an incident that is not with intent It was an incident that could not be avoided at 6 o’clock at night Christmas Eve where he hit a patch of ice,” Ritacca said adding that the victim may still be alive if the airbags had deployed The Lake County State’s Attorney’s Office filed a petition to detain Corona-Vargas pending trial “The defendant’s actions in this instant offense demonstrates his threat to the community as he put his life and the life of his friends in danger,” Shepherd said adding that Maldonado Guerrero lost his life as a result of Corona-Vargas’ decision to drive under the influence Lake County Judge Michael Nerheim granted the state’s petition during a detention hearing Friday afternoon The judge said Corona-Vargas poses a real and present danger to the community and that no conditions of release could mitigate the threat Corona-Vargas is scheduled to appear in court again on Wednesday for a status hearing No part of this website may be reproduced or stored in any form without written permission from Lake and McHenry County Scanner To keep you informed about the latest news across Lake and McHenry counties as it happens Host Leslie Sbrocco joins guests Francis Penrose Sonya Medema and Piña Bleep from KQED in San Francisco.Ready to discover some new Bay Area flavors Bay Area is back in November with handpicked recommendations for local restaurants you won’t want to miss On each episode of this James Beard and Emmy Award-winning series three locals sit down with host Leslie Sbrocco to rave about their favorite neighborhood eats After checking out each other’s spots debate and dish on their dining experiences From 12-hour lamb shoulder tandoor in San Francisco to rich bold flavors of Central Asian dishes in San Jose we’ve scoured the Bay for the best bites and standout spots so you don’t have to Thursdays beginning November 7 at 7:30pm on KQED 9 Here’s a sneak peek of what you can expect: Is your favorite restaurant missing from the lineup? There’s still time to shout out your go-to spot! We’re on the lookout for our next round of guests, and we want to hear from you. Nominate your can’t-miss picks and apply to be a guest now at kqed.org/checkplease/apply originally posted to Napa Police's Instagram shows the scene of a Monday evening crash outside of Villa Corona Villa Corona security footage reveals two children covering their heads and running seconds before a car drives over the curb and wipes out the tables Villa Corona security footage reveals the aftermath of a car that crashed into the restaurant's outdoor furnishings An out-of-control car driven by a Napa woman left the driveway at Bel Aire Plaza Monday evening and crashed through the dining patio at Villa Corona smashing furnishings and sending a family running for safety A video posted to the Napa Police Department’s Facebook page shows a woman and two young children exiting the store moments before the car drove up onto the curb The woman did not appear to notice the oncoming car barely clearing the corner before tables began flying toward the restaurant were taken to the hospital with minor injuries according to the Napa Police and Napa Fire Villa Corona owner Fernando Villasenor said the security camera footage kept him up last night “I was just so grateful that they started skipping and running.” Villasenor said the shopping center will bear some of the costs but the restaurant is looking at spending about $10,000 to replace the tables umbrellas and planters in front of the store Villasenor said the restaurant is open for business Napa Fire was called to the scene around 5 p.m Officials found the car crashed into a masonry wall that separates the rear of Bel Aire Plaza from a residential neighborhood The car stopped about 50 feet from someone’s house There was no sign of the crash outside of the restaurant Tuesday Saldivar said she was looking out the window The explosive impact coated the restaurant’s windows in dirt The car moved so fast that she only saw its tail as it turned the corner ‘It’s either a tornado or an earthquake.’” Saldivar’s mind went to the woman and children who had just exited the restaurant to see a small crowd starting to gather from nearby businesses The girl was hit by a table while trying to escape scraped her arm and said she felt pain in her head told Saldivar that the motorist almost hit his car He described the car as moving quickly and snaking through the parking lot “Thank God it was ugly weather” and nobody was eating or cleaning outside Napa Police did not offer an explanation for the incident but said medical factors did not appear to be at play in the crash No arrest was made in connection with the crash The nearby residential tenant told fire officials that something similar happened about a month ago when a Bel Aire Plaza patron in the parking lot got the gas and brake pedals confused They took out a large section of the stone wall right next to the area where the Napa woman crashed Monday View the store’s security camera footage of the crash here: Go to https://www.facebook.com/NapaPD/ The Napa Police Department says it's unable to determine whether the driver or mechanical error caused a car to jump the curb outside of Villa… Email notifications are only sent once a day Friends and family of Berryessa's Turtle Rock bar collected the money pined to the ceiling of the cafe to donate to UCSF and celebrate the 15-year 'cancerversary' of Elijah Leung Most of Napa’s River Park Shopping Center tenants cater to locals Now a handful of tenants have left the center The sheriff's office reported seizing 13 roosters from a Carneros site where it said the birds were altered and trained to fight other male birds Take a ride around Napa on these motorized ADA-compliant scooters made to look like various critters and creatures Young denied a bid by Alan Jazeel Martinez to dismiss a second-degree murder charge for the death of 17-year-old Monica Flores after a fentanyl overdose in 2022 Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Get up-to-the-minute news sent straight to your device Account processing issue - 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These reactive species have been proven to react with the water to produce plasma-activated water (PAW) with a notable transient broad-spectrum antimicrobial activity (Ma et al. Colloids and Surfaces A: Physicochemical and Engineering AspectsCitation Excerpt :However these methods have drawbacks of high energy consumption [10] inertial separation [13] and electrostatic deposition [14] are adopted to purify the oil mist in the air which also have defects of high energy consumption and high production cost [15] which can make use of the characteristics of the material to physically adsorb the oil in the oily wastewater and oily air and low-cost method for the treatment of oil pollution [16] All content on this site: Copyright © 2025 Elsevier B.V. Welcome Mickeymickey@disney.comManage MyDisney AccountLog OutVIDEO: 2 kids nearly hit by car that lost control slammed into restaurant patio in NapaWednesday 2019Milliseconds and millimeters are all that were between a car that lost control and two children who had just walked out of a restaurant.NAPA -- Two young children and a woman are lucky to be alive after a driver lost control and slammed into the outside dining area of Villa Corona restaurant in Napa's Bel Air Plaza on Monday The Napa Police Department posted stunning surveillance video of the crash on Facebook "This scary video is a good reminder to always be aware of your surroundings This family was just stepping out of a restaurant when the driver the car lost control Only minor injuries were reported when it was all said and done." the 60-year-old driver and a child who was about 2 or 3 years old were taken to the hospital with minor injuries An Instagram post from Napa police shows damage following the crash with debris scattered across the patio and sidewalk WAXED: GET YOUR MUSIC PRESSED ON VINYL FOR FREE The sleepy little town has really been growing and changing over that past 5 years with great additions to the neighborhood and a bangin' farmers market Umico Printing and Framing was welcomed into the neighbourhood about 2 years ago and has hosted countless exhibitions not just serving as a unique custom workshop but also creating a social hub Pop in and check out what Danny’s got going on whether you need a frame or not.  Short Iced Americano with a hmph of whole milk an hour before I saved his life with the Heimlich Maneuver WHO WOULD YOU LIKE TO SEE HAVE A SHOW IN THE GALLERY Umico Printing and Framing Experience the total solar eclipse from Eclipse Island Will you be in Shadowland, Texas, to see the total solar eclipse on April 8, 2024 How about watching the lunar disk cross the solar disk from Moon Beach You could visit thousands of locations to experience totality in Mexico but make sure you are within the path of totality Only then will you experience darkness in the middle of the day and be able to see the sun's corona with your own eyes at all other times precautions must be taken it will stretch 10,000 miles across the Pacific and Atlantic Oceans via North America Related: What time is the total solar eclipse 2024?Solar maximum: Why April's total Solar Eclipse will bring unique views of the sun's coronaTotal solar eclipse April 2024: 8 top tips for planning your trip'99% totality' does not exist! Why you need to get to the path for April 8, 2024, total solar eclipse  "These were the best ones that I found." Some have a history associated with historic solar eclipses; others are by pure chance.  Here are the highlights — and a complete list of all the eclipse-themed locations you could experience totality from on April 8 "The best one is Eclipse Island in Newfoundland," said Zeiler "It got that name because Captain James Cook observed an eclipse from that island."  An annular solar eclipse — known as a "ring of fire" — occurred on August 5, 1766 though if Cook did see it from Eclipse Island then he would have observed it from very close to the central path as an 84% partial solar eclipse.  Related: Where is the best place to see the April 2024 total solar eclipse? Northern Texas has two eclipse-related place names very close to each other in Red River County Sun Valley has a population of 69 and is seven miles east of Paris where a red cowboy hat sits on top of a 60-foot replica of the Eiffel Tower.  there are just as many eclipse-related names Virginia (79% partial solar eclipse) and the other near Houston Join our Space Forums to keep talking space on the latest missions, night sky and more! And if you have a news tip, correction or comment, let us know at: community@space.com. His special skill is turning tech-babble into plain English How to edit a solar eclipse photograph: A step-by-step guide Amateur astronomers capture groundbreaking photos of sun's corona during partial solar eclipse 10 must-have 'Star Wars' books and novels coming soon to your galaxy The Atwater Village favorite now keeps the lights on until 8 p.m After 25 years of servicing passersby along Glendale Boulevard in Atwater Village Tacos Villa Corona is ready to switch things up adding new evening hours for the first time in the restaurant’s history The massively popular weekend burrito shop is now doing weeknight food in addition to its usual breakfast and lunch routine Flores usually gets to the tiny storefront around 3 a.m. every day to do prep work, but had been switching things up and coming in around 5 a.m. instead, leaving prep work until after closing at 2 p.m. Eventually Flores decided that since he was still inside the restaurant anyway, he might as well serve customers who passed by and wanted some food and the exploration into longer hours grew from there Now Tacos Villa Corona is doing hours Tuesday through Friday until 8 p.m. on Saturday and Sunday because they usually sell out anyway Tacos Villa Corona3185 Glendale Blvd.Los Angeles Tacos Villa Corona co-owner Maria Flores has died. The longtime presence at the Atwater Village burrito walk-up passed away over the long weekend after an extended bout with ailing health according to the restaurant’s own Twitter page Flores was an integral part of the business she ran with her son and daughter helping to turn the tiny storefront into one of the city’s most heralded places for a weekend breakfast burrito Yesterday late afternoon our wonderful Matriarch Maria passed away in a peaceful slumber. We thank you all for all your thoughts, prayers, and support. She was a great women who loved everyone selflessly. May she forever be in our hearts pic.twitter.com/muulSxvoCj El Tejano in Woodland Hills has tightened up its hours, moving from daily service to weekend-only hours as it seeks a sale on Loopnet The Deli Boys is a new podcast all about Los Angeles Jewish delis The two-person team (comedians Evan Susser David Phillips) seeks to eat at 14 of the best around town ranking them as they dine out with special bi-weekly guests Downtown’s newest doughnut shop is Donut Friend the all-vegan spot that promised expansion to Broadway back in October A post shared by DONUT FRIEND (@donutfriend) on Jan 21 Roy Choi has some choice words when it comes to failure The Locol/Kogi/Best Friend Las Vegas chef spoke with GQ about what it means to go big in Sin City The Wallace is no longer doing lunch in Culver City The casual neighborhood restaurant run by chef Joel David Miller will continue with nightly dinner service Check out this new LA Magazine video with chef Ori Menashe as he walks through his process for making the renowned hummus at Bavel in the Arts District Metrics details Control over the protein corona of nanomaterials allows them to function better we comprehensively assessed the association of surface properties with the protein corona As revealed by in vitro measurements and computations the interaction between graphene/gold and HSA/IgE was inversely correlated with the hydroxyl group availability whereas the interaction between that and ApoE was comparatively less relevant Molecular simulations revealed that the number and the distribution of surface hydroxyl groups could regulate the manner in which nanomaterials interact with proteins we validated that ApoE pre-adsorption before injection enhances the blood circulation of nanomaterials relative to their pristine and IgE-coated counterparts This benefit can be attributed to the invulnerability of the complementary system provided by ApoE whose encasement does not increase cytotoxicity this study offers a robust yet simple way to create protein corona enriched in dysopsonins to realize better delivery efficacy which led to drastic pharmacokinetic changes that also determine the cytotoxicity of the nanoparticles rather than trying to realize its total elimination would allow the nanomedicine to function better These computational findings give us insights into the mechanism underlying the interaction of nanoparticles with proteins and show how the protein corona governs the identity of nanoparticles we demonstrate that the combined efforts of experimental and computational investigations can unveil a robust yet simple means of controlling the protein corona in vitro analyses and all-atom molecular dynamics (MD) simulations reveal that the availability of hydroxyl groups can affect the interaction of nanomaterials (herein graphene and gold) with three representative serum proteins (HSA strongly influence the composition of the subsequently formed protein corona We thus propose that coating nanomaterials with one type of serum protein before blood entry can help adjust their pharmacokinetics and that ApoE encasement unexpectedly leads to extended blood circulation Our study not only showcases how theoretical and experimental efforts can benefit from each other but also offers a promising approach to achieve long blood circulation via simple chemistry Structural information of Graphene and derivatives and their in vitro interaction with proteins b Graphene sheet (cyan) with different surface modifications in the experiment and simulation while G-all-OH stands for the graphene with the hydroxyl groups decorated onto both sides of the whole basal plane and the hydroxyl groups on G-half-OH was roughly half of that exposed by G-all-OH c AFM results of G-all-OH passivated with HSA d Results of DLS showing the size changes post protein adsorption e In vitro analyses showing the number of proteins adsorbed on the graphene p Values were calculated using multiple t tests (***p < 0.001 The simulation results of the interaction of HSA with the graphene sheet a Typical snapshots of the initial and final structures of the adsorption of HSA onto the sheet (cyan) with different surface modifications hydrophobic residues within 0.5 nm distance from the sheet surface are represented as CPK spheres Water molecules and ions are omitted for clarity c The contact surface area (CSA) and the Lennard–Jones (LJ) and Coulomb (Coul) interaction energy between HSA and the graphene with different surface modifications p Values were calculated using multiple t tests (*p < 0.05) The simulation results of the interaction of IgE with the graphene sheet a Typical snapshots of the initial and final structures of the adsorption of IgE onto the sheet (cyan) with different surface modifications c The contact surface area (CSA) and the Lennard-Jones (LJ) and Coulomb (Coul) interaction energy between IgE and the graphene with different surface modifications The simulation results of the interaction of ApoE with the graphene sheet a Typical snapshots of the initial and final structures of the adsorption of ApoE onto the sheet (cyan) with different surface modifications c The contact surface area (CSA) and the Lennard–Jones (LJ) and Coulomb (Coul) interaction energy between ApoE and the graphene with different surface modifications p Values were calculated using multiple t tests (NS stands for statistically insignificant difference) although the adjustment of hydrophilicity by tuning the hydroxyl group availability of graphene can influence the protein adsorption behavior their manner of action in terms of CSA was affected in different ways their numbers of adsorbed hydrophobic residues and the CSA decreased with increasing number of hydroxyl groups no positive correlation existed between the CSA of ApoE and sheet hydrophilicity Structural profiles of adsorbed proteins a Secondary structure content of different proteins on the graphene after 200 ns MD simulation (Free: the secondary structure content of the proteins in the water) b Schematic illustration of three new designed graphene sheets (Janus pattern-1 and pattern-2) in the simulation: they have the same number of hydroxyl groups as G-half-OH whereas the modified area (modified with hydroxyl groups) and the unmodified area (pristine graphene) are distributed at intervals the distance of the interval (defined as d) is about 4.2 d The CSA and the secondary structure content of ApoE adsorbed on the different sheets the upper and lower quartile as outlined by top and bottom boundary were divided by line showing the median value p Values were calculated using multiple t tests (****p < 0.0005 and NS stands for statistically insignificant difference) the ApoE protein could rearrange to somewhat fit the hydrophobic and hydrophilic domains on the graphene surface although complete reconfiguration is not feasible It is thus reasonable to see some bad adsorption in certain cases there might also exist some unexpected interactions between the residues and the nearby domains of the nanomaterials (in this case the hydrophobic residues cannot just adsorb onto the hydrophobic region and may also interact with the hydrophilic region) the limited distance between the regions of the hydroxyl groups could hinder protein adsorption graphene carrying Janus-like hydroxyl groups might be the best choice meaning that the measurement of Gd content in vivo faithfully reflected the amount of graphene The Gd-labeled G-half/all-OH samples were passivated with IgE/ApoE before injection into tumor-bearing mice through the tail vein Uncoated G-half/all-OH samples were assessed under identical conditions for comparison We sacrificed these mice at various time points after injection and collected several organs and blood samples b Biodistribution of G-half/all-OH and Au-half/all-OH in four tissues including liver (n = 3 at each time point) as a function of time We also extended this approach to iron oxide, a substance well known for its ability to enhance the T2 contrast under magnetic resonance imaging. As the images show (Supplementary Fig. 7) obviously reduced liver accumulation can be observed when the nanoparticles were coated with ApoE prior to the administration compared with their IgE-coated or pristine counterparts in which cases the liver tissue was darker Biological implications of pre-adsorbed proteins a Proteomic analysis showing the composition of protein corona encasing G-half/all-OH and PG pre-coated with ApoE/IgE the pie-chart was generated based on the number of recognized proteins belonging to each of the seven categories including lipoproteins b Macrophage uptake of dye-labeled G-all-OH and counterparts coated with ApoE or IgE Lysosome compartment and nucleus were stained to guide the eyes c Quantified uptake by macrophages of Au-all-OH and protein-coated counterparts p Values were calculated using multiple t tests (***p < 0.001) The amount of pre-adsorbed proteins on nanomaterials were quantified using ICP-MS at 24 h post the administration of G-all/half-OH with the percentage of remainder capping layer calculated as described in the experimental section Cell-dense tumor and high IFP stand for the xenograft grown from H22 cells and EMT-6 cells The PDX model was established by transplanting the tissue sections harvested from breast cancer-suffering patients into nude mice a Content of Au element remained in blood and three tissues The mice carrying tumor received six types of materials including Au-half/all-OH in the pristine forms and their four derivatives coated with either ApoE or IgE p Values were calculated using multiple t tests with no inner-group difference of statistical significance can be found b Pathological analysis of major organs after a 7 and 30 days of exposure to ApoE-coated Au-all-OH The tissue sections were stained with H&E c Changes in the levels of biomarkers that would indicate a compromised tissue function Taking several types of broadly employed materials as examples we showed here that the availability of hydroxyl groups can be harnessed to manipulate the protein corona and contributes a simple yet robust approach to extend the blood circulation of nanomaterials Combining the efforts of in vitro analysis and computation we found that increased hydrophilicity substantially compromises the passivation of graphene by HSA and IgE whose adsorption results in faster clearance from blood a critical member of the dysopsonin family that plays a role opposite to the opsonins is unaffected by changes in hydrophilicity a shift in surface properties towards hydrophilicity can effectively help resist passivation by bad proteins while leaving good ones nearly unaffected We further comprehensively investigated how pre-coating with proteins remodeled the manner in which nanomaterials are recognized by the MPS and professional phagocytes by using proteomics and fluorescence imaging All these findings pointed out that prior coating with ApoE helps maintain a corona rich in dysopsonins which eventually endow the nanomaterials with enhanced enrichment in tumor tissue Such an effect exerted by ApoE is not long lasting possibly owing to the gradual loss of attachment during biological fluid exposure which unintentionally addresses the concern of long-term safety We believe that this insight into protein–nanomaterials interactions and their association with hydrophilicity along with the protein pre-coating methods proposed herein can promote better utilization of nanomaterials’ therapeutic power ferrous chloride tetrahydrate (FeCl2·4H2O) and ferric chloride hexahydrate (FeCl3·6H2O) were all purchased from Sinopharm Chemical Reagent Co. gold(III) chloride trihydrate (HAuCl4·3H2O) diethylenetriaminepentaacetic acid (DTPA) N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide hydrochloride (EDC) and gadolinium chloride (GdCl3) were all purchased from Sigma-Aldrich (United States) Natural graphite was obtained from XFNANO Co. All chemicals except N2H4 were of analytical grade and used as received without further purification Deionized (DI) water with a resistivity of 18.2 MΩ cm was used in all experiments which was produced by a Millipore ultrapure water system (United States) Mouse breast cancer cell line (EMT-6) and Mouse monocyte/macrophage cell line (RAW 264.7) were all obtained from American Type Culture Collection (ATCC) They were both cultured and maintained in the growth medium of DMEM supplemented with 10% FBS and 1% penicillin/streptomycin Cultures were maintained in an incubator at 37 °C in a humidified atmosphere of 5% CO2 The medium was replaced every other day until a ca Mouse hepatoma cell line (H22) was obtained from Chinese Academy of Sciences and passed regularly to another one once the number of cells reached ca The morphology of nanoparticles was investigated by high resolution transmission electron microscopy (TEM-2100 The Zeta-potential and DLS profiles of nanomaterials were analyzed at room temperature by using Litesizer TM500 (Anton-Paar) Analysis with atomic force microscopy was conducted on Dimension Icon (Bruker) The proteomic analysis was conducted on hybrid dual-cell quadrupole linear ion trap-Orbitrap mass spectrometer (LTQ Orbitrap Elite Fluorescence images were collected on inverted fluorescence microscope (IX83 Olympus) equipped with a live-cell culture chamber (ibidi) supplemented with 5% CO2 Female BALB/c mice (4–6 weeks) and female BALB/c nude mice (6–8 weeks) were both purchased from the Comparative Medicine Centre of Yangzhou University and used for the in vivo tests All the protocols for the animal tests have been reviewed and approved by the Committee on Animals at Nanjing University and performed in accordance with the guidelines provided by the National Institute of Animal Care Both G-all-OH and G-half-OH can be dispersed in PBS and were stored at room temperature before future use Those freshly prepared Au nanospheres carried CTAC capping layer were next washed for two times with DI water followed by transferring into solution containing PVP (3 mM) and AA (40 mM) After gentle shaking to mix well of these components aqueous solution containing AgNO3 was introduced The rapid change in color of the solution indicated the success of Ag deposition along with the exclusion of previous CTAC ligands The reaction was allowed to proceed for 10 min before the addition of acetone to lower the solubility of PVP-capped Au@Ag nanospheres We harvested these products through centrifugation and resuspended them in DMF containing either thiol-terminated alkyl alcohol (C8) or alkyl thiol (C8) to create Au-all/half-OH or Au-CH3 Removal of the Ag layer was induced by the introduction of H2O2 during which the C8 ligands got access to and thereby passivated the outer surface of pristine Au nanospheres the mole ratio of C8 ligands to Au nanospheres to prepare fully hydroxylated particles was set to be 1500: 1 whereas the reduced input of C8 ligands at a ratio of roughly 750: 1 against particles was employed to synthesize Au nanospheres bearing halved hydroxyl groups All these Au nanomaterial derivatives were collected via centrifugation (22,000g × 30 min) followed by three washes with DI water They were suspended in phosphate-buffered saline (PBS) and stored at 4 °C and kept from direct sunlight irradiation All three types of proteins were obtained from Sigma-Aldrich in the form of powder they were fluorescently labeled with Alexa Fluor-633 using the peptide labeling kit (Thermo Fisher Scientific the concentrations of proteins were quantified using BCA assay (Thermo Fisher Scientific) with its correlation with the fluorescence intensity (measured by fluorescence spectrometer Shimadzu) was established to guide the estimation of proteins adsorbed onto nanomaterials 1 mg of protein was introduced into PBS and mixed well under vigorous shaking before the addition of graphene (final concentration: 10 mg mL−1) the protein adsorption was allowed to proceed for 4 h under gentle shaking at 37 oC the mixture was protected from direct exposure to light We collected the supernatant of the solution after centrifugation (20,000g × 30 min) with its fluorescence intensity measured following procedures mentioned above The number of proteins adsorbed onto nanomaterials were calculated based on the calculated reduction of fluorescence intensity For the assessment of adsorption onto Au nanospheres the tests were conducted under identical condition except that the final concentration of nanospheres incubated with proteins was set to be 1014 particles per mL and the size of the Au surface with 8.0 × 6.0 nm3 for ApoE and IgE the size of simulation box was 10.5 × 8.5 × 7.0 nm3 for ApoE/IgE-graphene system 12 × 11.5 × 10.0 nm3 for HSA–graphene system 10 × 8 × 8.5 nm3 for ApoE/IgE-Au system and 11 × 10.5 × 11 nm3 for HSA–Au system the protein and the nanoparticles were placed in a cubic box and placed at a minimum distance of 1.0 nm between any heavy atom of protein and the sheet surface Then the simulation box was solvated with plenty of water molecules Na+ or Cl− ions were added to neutralize the systems the restriction of the graphene sheet and protein was turned off and the system was performed in the NVT ensemble at 298 K for 200 ns Each system was simulated six times by changing the speed seed To quantitatively depict the adsorption behavior of protein onto graphene the CSA between protein and graphene was introduced and SASApro+gra represented the solvent accessible surface area of protein The VMD software was used for trajectory visualization and analysis The dose regimen was fixed at 10 mg (in terms of graphene) for each mouse These tissues were subjected to repeated frozen-thaw treatments followed by digestion in boiling aqua regia (HNO3: HCl vol/vol).The content of Gd was used to reflect the amount of graphene enriched in corresponding tissue using ICP-MS For the assessment of Au nanosphere distribution in vivo tests were conducted under identical condition except that the graphene was replaced by different types of 50-nm Au nanospheres (50 mg kg−1 weight) Alexa Fluor-633-labeled protein was used for the passivation of Gd(III)-labeled graphene The original fluorescence intensity and the content of Gd of the sample were measured with fluorescence spectra and ICP-MS with their ratio calculated and leveraged to estimate the loss of original protein corona the injection of graphene was conducted as did for the analysis of biodistribution The mice were next sacrificed at 24 h post injection with the collected blood and tissues divided into two parts One-half of the sample was analyzed with ICP-MS to quantify the amount of graphene itself Other half was minced via the 400-mesh screen with the harvested single cell suspension stored at −80 °C overnight in order to disrupt the cell integrity the cell suspension was centrifugated (3000g × 10 min) to get rid of cell debris We analyzed the fluorescence intensity of the supernatant and recalculated the ratio of [dye]/[graphene] the loss of original protein corona can be reflected by the changes in such a ratio after the injection To understand the preservation of coated proteins after 30 days Au nanospheres carry either ApoE or IgE were injected into the tumor bearing mice (in this case to keep the mice alive during the observation period the original volume of tumor at the start point was set to 50 mm3 half of the value of previous biodistribution analysis) The tumor bearing mice were sacrificed 30 days later and the content of gold remained in tumor tissue was analyzed by using ICP-MS with the value of mice received pristine Au-all/half-OH served as control for comparison and dispersed in phosphate buffer saline (pH ~7.2) Into the suspension we next introduced the proteins (final concentration: 10 mg mL−1) to fully passivate the surface of nanomaterials healthy mice received different types of Fe3O4 nanoparticles through tail vein injection the T2-weighted MR images were collected on 7T ClinScan modality (Bruker) Triplicate data were analyzed with multiple t tests using GraphPad Prism software (version 7.0); the significance level was set at p < 0.05 Significant statistical differences are indicated by asterisks in corresponding figures Further information on research design is available in the Nature Research Reporting Summary linked to this article The authors declare that the data supporting the findings of this study are available in the article and Supplementary Information Raw data or more information supporting the conclusion are available from the corresponding authors upon reasonable request Mesoporous silica nanoparticles deliver DNA and chemicals into plants Loading of an anti-cancer drug into mesoporous silica nano-channels and its subsequent release to DNA Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery pH-activated size reduction of large 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stealth effect of nanocarriers through understanding the protein corona Revealing the importance of surface morphology of nanomaterials to biological responses: adsorption of the villin headpiece onto graphene and phosphorene Effect of graphene oxide on the conformational transitions of amyloid beta peptide: a molecular dynamics simulation study The helical hydrophobic moment: a measure of the amphiphilicity of a helix Allosteric effects of gold nanoparticles on human serum albumin Regional and segmental flexibility of antibodies in interaction with antigens of different size Can dual-ligand targeting enhance cellular uptake of nanoparticles Enabling complete ligand exchange on the surface of gold nanocrystals through the deposition and then etching of silver In vivo integrity of polymer-coated gold nanoparticles Nanoparticle-liver interactions: Cellular uptake and hepatobiliary elimination Statin prevents plaque disruption in apoE-knockout mouse model through pleiotropic effect on acute inflammation Salt bridge relay triggers defective LDL receptor binding by a mutant apolipoprotein Accelerated disassembly of IgE–receptor complexes by a disruptive macromolecular inhibitor Crystal structure of human serum albumin at 2.5 Å resolution GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit Development and testing of the opls all-atom force field on conformational energetics and properties of organic liquids Molecular dynamics study of the aggregation process of graphene oxide in water Fluorescence probing of thiol-functionalized gold nanoparticles: is alkylthiol coating of a nanoparticle as hydrophobic as expected Molecular dynamics with coupling to an external bath Graphene oxide based theranostic platform for T1-weighted magnetic resonance imaging and drug delivery Synthesis and application of strawberry-like Fe3O4-Au nanoparticles as CT-MR dual-modality contrast agents in accurate detection of the progressive liver disease Download references This work is supported by the National Natural Science Foundation of China (Nos Start-up funds of Nanjing Medical University to D.H. and Fundamental Research Funds for the Central Universities (0214-14380452) We are grateful to the High Performance Computing Center (HPCC) of Nanjing University for doing the numerical calculations in this paper on its blade cluster system These authors contributed equally: Xiang Lu National Laboratory of Solid State Microstructures and Department of Physics Collaborative Innovation Center of Advanced Microstructures Center for Soft Condensed Matter Physics and Interdisciplinary Research conceived the idea and co-designed the simulation/experiment Y.-S.Y participated in performing the simulation performed the in vitro and in vivo assessments with the assistance of P.X All authors have proof-read the paper and approved its publication in the present form The authors declare no competing interests Peer review information Nature Communications thanks Congyu Wu and other reviewers for their contributions to the peer review of this work Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41467-019-12470-5 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Drug Delivery and Translational Research (2024) Sign up for the Nature Briefing newsletter — what matters in science Please enable JS and disable any ad blocker Print CORONA — Corona High junior Seth Hernandez is known as the top two-way baseball player in the class of 2025 Huntington Beach hit decently against Hernandez on Tuesday in the semifinals of the CIF Southern Section Division 1 playoffs But then he turned to his bat to do damage Hernandez launched a two-run home run in the bottom of the sixth inning as the Panthers beat the Oilers to book their spot in the Division 1 title game 2-seeded Studio City Harvard-Westlake for the championship on Saturday at 7:30 p.m “We’ve got a second chance,” Medure said. “We know it’s not the CIF championship game, but we don’t care. We get to play together and play for something, and that means something to us, so we’ll do it.” Huntington Beach (23-9) lost to National High School Invitational tournament champion Corona for the third time this season, by a total of five runs. Oilers junior right-hander Tyler Bellerose was certainly up to the challenge Tuesday, allowing just one earned run in his five innings of work. Corona still struck first in the bottom of the fourth inning on a two-out rally. Hernandez singled to right, and took third on another single by Josh Springer. Hernandez then scored on a wild pitch, the third straight pitch in the dirt by Bellerose, with junior catcher Trent Grindlinger blocking the first two. Tyler Bellerose (14) of Huntington Beach, shown against Villa Park earlier this season, pitched five strong innings on Tuesday. (Don Leach / Staff Photographer) “We were just trying to miss down, you know, but it was just too down,” Medure said. “It caught the front of the plate and it shot up over the top of our catcher. Just one of those things.” Huntington Beach tied the score in the sixth, on a towering solo home run to right by sophomore CJ Weinstein on a 2-0 pitch. It was the third homer of the year for Weinstein. He was two for three to account for half of the visitors’ hits — Ethan Porter hit a leadoff double in the first and Travis Curry singled in the fifth. “When you fall behind, it’s tough to get it back, especially good hitters like CJ,” said Hernandez, who allowed the one earned run in six innings and is now 9-0 this season with a 0.50 ERA. “He’s a great hitter. He’s gotten me every time we’ve played. Falling behind hurt me there, but I just adjusted after that, got it back.” Medure brought in freshman phenom right-hander Jared Grindlinger in the bottom of the inning. With one out, Brady Ebel reached on a high pop-up that landed in fair territory just in front of home plate. “You teach your pitcher not to catch fly balls or pop-ups,” Medure said. “But in that case, that’s the time to catch it, right? He’s an outfielder — he’s a good athlete — but his brother called him off and the ball dropped. Then it’s a two-run home run. It’s a tricky play, and it happens right at the worst time for us.” Indeed, Hernandez followed with a homer to left — his eighth of the season — on a 2-1 changeup over the middle. Billy Carlson pitched a 1-2-3 scoreless seventh inning to earn the save for Corona, which has advanced to its first CIF title game since 2017. Huntington Beach was vying for its third CIF Southern Section title game appearance, the first since the program’s lone championship in 2015. “It’s tough, especially when you play a team so much and see them more and more,” Hernandez said of his team’s close games with the Oilers this year. “I don’t think it gets easier, I think it gets harder. They’re a great team, great organization. I know a lot of the guys over there, and they’re all dogs, so it felt good to get the win for sure.” Matt Szabo covers the city of Huntington Beach and sports for the Daily Pilot. A Southern California native and Cal Poly San Luis Obispo graduate, he has been working for L.A. Times Community News since 2006 and still loves talking to people about their hopes and dreams. Sports News Subscribe for unlimited accessSite Map Metrics details the novel coronavirus pandemic has dramatically affected the world by producing 4.8 million deaths Mathematical modeling is one of the useful mathematical tools which has been used frequently to investigate the dynamics of various infectious diseases It has been observed that the nature of the novel disease of coronavirus transmission differs everywhere implying that it is not deterministic while having stochastic nature a stochastic mathematical model has been investigated to study the transmission dynamics of novel coronavirus disease under the effect of fluctuated disease propagation and vaccination because effective vaccination programs and interaction of humans play a significant role in every infectious disease prevention We develop the epidemic problem by taking into account the extended version of the susceptible-infected-recovered model and with the aid of a stochastic differential equation We then study the fundamental axioms for existence and uniqueness to show that the problem is mathematically and biologically feasible The extinction of novel coronavirus and persistency are examined and sufficient conditions resulted from our investigation some graphical representations support the analytical findings and present the effect of vaccination and fluctuated environmental variation The causative agent was the novel coronavirus also known as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) It was identified in January 2020 by isolating a single patient The SARS-CoV-2 pandemic infected 589 million people and produced 6.5 million deaths up to August 2022 around the world WHO has declared that it is an international public health emergency The SARS-CoV-2 virus is highly infectious due to rapid spreading around the globe The potential spreading of the disease is a complex issue for public health Typical symptoms of SARS-CoV-2 infection include cough Vaccination plays a vital role in disease prevention Recently after the pandemic of the SARS-CoV-2 virus and ultimately the immunization programs go massively to reduce the depreciation of the novel coronavirus disease effective control mechanisms are forecasted to suggest useful guidelines for health officials and take serious steps to control various infectious diseases The control of novel coronavirus is a challenging task and attracts the attention of various researchers The main contribution of this paper is to formulate an alternative stochastic epidemiological model for the SARS-CoV-2 virus with the aid of a stochastic differential equation and to incorporate the fluctuated disease prorogation as well as including the effect of vaccination according to the characteristic of the disease The graph demonstrate the evolution and schematic process of the novel corona virus propagation We present the proposed stochastic model: susceptible-infected and recovered model under the effect of vaccination and varying population by placing the following constraints in terms of some assumptions and constants of the problem are non-negative values We symbolize the total population by x(t) divided into various population groups of susceptible Mathematically we can write as \(x(t)=s(t)+i(t)+r(t)\) as varies against t The pandemic of SARS-CoV-2 rises due to human contact The transmission everywhere differs; therefore the various groups of the model are driven by the equal randomness or source as symbolized by B(t) The change in these populations groups is associated with the same information source demonstrated by the Brownian motion filtration \(F=(F_t)_{t\in [,T]}\) where \(F_t:= \sigma (B(t))\) is the s-algebra as generated by the Brownian motion B(t) The results show that a variation in a group has an impact directly on the other group We fluctuate the disease transmission parameter in such a way that \(\alpha \rightarrow \alpha +\varrho {\dot{B}}(t)\) where the standard Brownian motion is symbolized by B(t) is and so \(B(0)=0\) and \(\varrho\) is the white noise intensity satisfying \(\varrho ^2>0\) The vaccination of susceptible populations will be accorded permanent immunity the governing equations of the models ultimately take the following form where the detailed characterization of the model parameters is as we use \(\Lambda\) as a parameter for the newborn rate while the death rate (natural and disease) are symbolized by \(\mu\) and \(\mu _1\) respectively The vaccination rate of susceptible is assumed to be v and \(\gamma _1\) is the natural recovery or the recovery due to treatment \(\varrho\) is the environmental white noise intensity while B(t) denotes the scalar standard Brownian motion If we put \(\varrho =0\), the system (1) reduces to its associated deterministic form we ultimately derive the equilibria (disease-free and endemic) as given by \(e_0\) and \(e_{*}\) whose components are given Where \(R_0\) is the threshold quantity (basic reproductive number) represents the expected number of secondary infections produced by a single infective whenever introduced into a susceptible population calculated with the aid of the next-generation method approach It could be observed that either the epidemic rises or dies out depending on the value of the basic reproductive number Here we will discuss a brief sensitivity analysis of the basic reproductive number Which provides the relative impact of the model parameters and threshold quantity the sensitivity index of a parameter \(\psi\) is denoted by \(S_{\psi }\) and defined by the following equation The graph shows the variation of the basic reproductive number against the parameters \(\alpha\) and v. The graph demonstrate the variation of the basic reproductive number against parameters \(\alpha\) and \(\gamma _1\). The variation of the basic reproductive number for the parameters \(\gamma _1\) and v We show that the model (1) has a unique solution, positive as well as global, and therefore the proposed problem (1) is well-posed Regarding the existence and uniqueness analysis The solutions to the proposed problem, as stated by Eq. (1) is unique for any initial conditions in \(R^{3}_{+}\) the solution will also remain in \(R^{3}_{+}\) with probability 1 \((s(t),i(t),r(t))\in R^{3}_{+}\) for \(t\ge 0\) a.s (almost surely) then there exists a solution on the interval of \(t\in [0,\tau _e)\) with the explosion time \(\tau _e\) It is now required to investigate whether the solution satisfies the global properties We assume that \(k_0\) is non-negative and sufficiently large and \(r_0\) lie in \(\big [\frac{1}{k_0},k_0\big ]\) It is clear that increase in \(\tau _k\) is related to k as \(k\rightarrow \infty\) then it is increasing and therefore making the substitution of \(\tau _\infty =\lim _{k\rightarrow \infty }\) implies that \(\tau _\infty \le \tau _e\) a.s We will prove that \(\tau _\infty =\infty\) for investigating \(\tau _e=\infty\) and so (s(t) it is needed to show that \(\tau _e=\infty\) a.s if this is not true and the statement becomes false \(T>0\) and \(\epsilon \in (0,1)\) exist which satisfy Obviously \(G\ge 0\) as \(-\log q+q-1\ge 0\) for every \(q>0\). Choosing \(T>0\) and \(k\ge k_0\) are two arbitrary constants, then It\({\hat{o}}\) formula for Eq. (9) gives Using Eq. (8) in Eq. (11) may gives the following assertion Putting \(\Omega _k={\tau _k\le T}\) whenever \(k\ge k_1\) then using Eq. (6) imply that \(P(\Omega _k)\ge \epsilon\) It is also noted that for all \(\omega\) in \(\Omega _k\) \(r(\omega ,\tau _k)\) at least once that is equal to \(\frac{1}{k}\) or k and so \(G(s(\tau _k),i(\tau _k),r(\tau _k))\) is not less then \(-\log k+k-1\) or \(-1+\frac{1}{k}+\log k\) Therefore, Eqs. (6) and (13) implies that where \(1_{\Omega (\omega )}\) is used to represent the indicator function of \(\Omega\) If \(k\rightarrow \infty\) then \(\infty >H\big (s_0,i_0,r_0\big )+TM=\infty\) occurs which shows that \(\tau _\infty =\infty\) a.s Further, it could be investigated that the solutions of the proposed problem are positive, so the first equation of the system (1) gives the solution implies that s(t) is positive. Similarly the second assertion of the model (1) looks like Clearly Eq. (17) gives that i(t) has non-negative values On the same way we can prove that r(t) is positive It could be noted from the above result as stated by theorem 4.1 that for any initial conditions in \(R_{+}^3\), the unique global solution of system (1) exists a.s The above Eq. (18) yields Clearly \(x(t)\le \Lambda /\mu\) a.s, if \(x(0)\le \Lambda /\mu\) and the feasible region for our considered model (3) is defined as We investigate how the disease could be eradicated We use some basic definitions and notations that will be used in the upcoming analysis We also assume that the threshold quantity (basic reproductive number) symbolized by \(R_0^S\) for the proposed model (1) is given by For the proposed problem, as stated by Eq. (1) holds then the novel disease of coronavirus persists in the mean We describe the analysis regarding the analysis of extinction with the help of the following theorem If \(R_0^S<1\) and \(\alpha (\mu +v)>\varrho ^2\Lambda\) is satisfied then the following holds for the solutions of the proposed model which describes that i(t) approaches 0 exponentially and where \((s^0,0,r^0)\) is the disease free equilibrium of the deterministic version of the proposed problem We integrate both sides of system (1) and obtain The addition of the first two equations of the above system (24) leads to the assertion Clearly \(\phi (t)\) approaches 0 whenever t approaches \(\infty\). Moreover, again system (1) and It\({\hat{o}}\) formula application gives Integrating both sides of Eq. (26) and dividing by t with some algebraic manipulation Now making use of \(R_0^S\) in the above equation implies Thus Eq. (28) can be also re-written as If \(R_0^S<1\) and \(\alpha (\mu +v)>\varrho ^2\Lambda\) hold, then Eq. (30) gives We show the assertion (22) Solving Eq. (32) which yields We apply the L’Hospital rule to the above Eq. (33) and substitute Eq. (31) The solution of the limiting system of the 1st equation of model (1) gives We discuss the analysis of persistence with the help of the theorem as stated below If \(R_0^S>1\) and \(\alpha (\mu +v)>\varrho ^2\Lambda\) then for any initial conditions in \(\Omega ^{*}\) the solution of system (1) satisfies We can write from Eq. (28) that Again the use of Eq. (25) in Eq. (27) gives The re-arrangement and taking \(\lim\) inferior Thus Eqs. (39) and (41) leads to the conclusion which is required \(\square\) the numerical simulation is given to verify the analytical work we present a short overview of the discretization of stochastic differential equations models Producing a sample X(t) around t with the utilization of the solution of the above equation, we will find X(t) over a continuous period. Making use of the notation \({\tilde{X}}_k\), \(B_k\) and \({\tilde{X}}(k\Delta t)\) for simplicity instead of \(B(k\Delta t)\). Thus the discretization of Eq. (42) gives where N symbolizes the time steps and \(\Delta t=T/N\). It could be noted that the application of Itô-Taylor expansion leads to the stochastic Euler Maruyama (SEM) method to simulate the proposed stochastic model. We retrieve the discretized trajectory of X(t) from the Eq. (42) we may use the algorithm of Euler Maruyama: Simulate \(\Delta B_k\) as a normal distributed random variable \(N(0 Putting \({\tilde{X}}_0:=X_0\) and applying \({\tilde{X}}_{k+1}\) by following the formula given below for \(\Delta B_k=B_{k+1}-B_k\) and \(k=0,\ldots ,N-1\) We utilize the above technique for simulation of the corona model as stated by Eq. (1) to investigate the verification of our theoretical findings which lead to the following system as defined by where \(\Delta B_k\) is the random variable and are independent \(N(0, \Delta t)\) normally distributed random variables. We can also write the system (45) as The graphs demonstrate the extinction and persistence analysis of the SARS-CoV-2 virus transmission using the proposed model (1). The graphs illustrate the effect of vaccination on the dynamics of susceptible, infected and recovered population in case of disease extinction. We noted that whenever the progress of vaccination are increases, the susceptible and infected population are decreases while the recovered population are increases. The graphs represent the temporal dynamics of the model against various values of white noise intensity in case of disease extinction, which reflects that there is no considerable effect of white noise intensity on the disease dynamics. The graphs represent the effect of vaccination on the dynamics of various compartments in case of the persistence analysis of the model (1). The graphs represent the effect of white noise intensity on the dynamics of the compartmental population of the epidemic problem (1) in case of disease persistence analysis The novel coronavirus disease transmissions are investigated with the help of a stochastic epidemic model under the effect of vaccination and fluctuated incidence rate The stochastic model is formulated according to the characteristics of the disease and studies the basic fundamental axioms of well-posedness for biological and mathematical feasibility We also discussed the detailed analysis of the extinction and the persistence analysis to identify sufficient conditions in terms of the model parameters We simulated the model to support the analytical work and to present the impact of vaccination and the intensity of white noise It could be noted that the stochastic process have a positive influence on disease transmission and its elimination We observe that the effect of vaccination and white noise intensity have a direct relation with the extinction of the disease and are inversely related to the disease persistence It is observed that as the values of these parameters increase we will take the extended version of the proposed model to formulate a control problem keeping in view the current scenario to find the optimal methods for the elimination of the current pandemic of the novel disease of the coronavirus All data generated or analyzed during this study are included in this published article novel coronavirus (2019-nCoV) infections among travellers from Wuhan From SARS-CoV to Wuhan 2019-nCoV outbreak: Similarity of early epidemic and prediction of future trends Design and application of nature inspired computing approach for nonlinear stiff oscillatory problems Integrated intelligent computing paradigm for the dynamics of micropolar fluid flow with heat transfer in a permeable walled channel Neuro-computing networks for entropy generation under the influence of MHD and thermal radiation Intelligent numerical computing paradigm for heat transfer effects in a Bodewadt flow Stationary distribution and extinction of stochastic coronavirus (COVID-19) epidemic model Prudent public health intervention strategies to control the coronavirus disease 2019 transmission in India: A mathematical model-based approach Backpropagated intelligent networks for the entropy generation and joule heating in hydromagnetic nanomaterial rheology over surface with variable thickness Backpropagated intelligent computing networks for 3D nanofluid rheology with generalized heat flux Stability analysis and optimal vaccination of an sir epidemic model A stochastic differential equation sis epidemic model Extinction and stationary distribution of a stochastic sirs epidemic model with non-linear incidence Synchronization of epidemic systems with Neumann boundary value under delayed impulse Hepatitis b in a high prevalence New Zealand population: A mathematical model applied to infection control policy Modeling the transmission dynamics and control of hepatitis B virus in China Mathematical analysis of a cholera model with public health interventions A comparison of delayed SIR and SEIR epidemic models Analytical and approximate solutions of a novel nervous stomach mathematical model A novel study of Morlet neural networks to solve the nonlinear HIV infection system of latently infected cells Solving a class of biological HIV infection model of latently infected cells using heuristic approach An advanced heuristic approach for a nonlinear mathematical based medical smoking model Numerical investigations of the nonlinear smoke model using the Gudermannian neural networks Artificial neural network scheme to solve the nonlinear influenza disease model Nowcasting and forecasting the potential domestic and international spread of the 2019-nCoV outbreak originating in wuhan Host and infectivity prediction of Wuhan 2019 novel coronavirus using deep learning algorithm Transmission of 2019-nCoV infection from an asymptomatic contact in Germany The prediction and analysis of COVID-19 epidemic trend by combining LSTM and Markov method Summary of the COVID-19 epidemic and estimating the effects of emergency responses in China Modeling the role of asymptomatics in infection spread with application to SARS-CoV-2 Quantifying the effect of Remdesivir in rhesus macaques infected with SARS-CoV-2 Characterization of the COVID-19 pandemic and the impact of uncertainties and underreporting of cases in south korea Critical fluctuations in epidemic models explain COVID-19 post-lockdown dynamics A mathematical model of the evolution and spread of pathogenic coronaviruses from natural host to human host Modeling and stability analysis of the spread of novel coronavirus disease COVID-19 Dynamical analysis of a novel discrete fractional SITRS model for COVID-19 A stochastic computational intelligent solver for numerical treatment of mosquito dispersal model in a heterogeneous environment Integrated intelligent computing application for effectiveness of au nanoparticles coated over MWCNTs with velocity slip in curved channel peristaltic flow Hall effect on MHD Jeffrey fluid flow with Cattaneo–Christov heat flux model: An application of stochastic neural computing Intelligent Bayesian regularization networks for bio-convective nanofluid flow model involving gyro-tactic organisms with viscous dissipation Stochastic numerical investigations for nonlinear three-species food chain system Survival and stationary distribution of a SIR epidemic model with stochastic perturbations Stability of sirs system with random perturbations Threshold behaviour of a stochastic sir model Dynamical behaviors of a stochastic SIRI epidemic model Download references Qasem Al-Mdallal sincerely acknowledges United Arab Emirates University UAE for providing financial support with Grant No We would also want to thank the Deanship of Scientific Research (Project No.: RGP.2/214/43) acknowledges with thanks to DSR and the Chemical Engineering Department in the College of Engineering (KKU) for financial and technical support These authors contributed equally: Rahman Ullah School of Mathematics and Statistics Hunan Department of Basic Sciences and Humanities College of Electrical and Mechanical Engineering National University of Sciences and Technology (NUST) All authors of this research paper have directly participated in the planning All authors have approved and read the final version Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-023-30647-3 Journal of Applied Mathematics and Computing (2024) Sign up for the Nature Briefing: AI and Robotics newsletter — what matters in AI and robotics research Posted by | Jan 31 PASO ROBLES – The California Mid-State Fair is pleased to announce that Banda Machos has been confirmed to perform at the 2020 Fair on Sunday The concert will take place on the Frontier Stage and will be included with paid Fair admission Banda Machos is a Mexican band originally from Villa Corona The band sings a combination of Banda music Banda Machos has performed songs composed by Joan Sebastian The band has been together for over 26 years and has recorded over 22 albums. The 2020 California Mid-State Fair runs July 22 – August 2 and this year we’re celebrating our 75th Anniversary Articles published by Paso Robles Press may be publicly submitted press releases or other forms of media not specifically authored by a member of our News Staff Paso Robles Press is the community’s top-ranked news source for Paso Robles mailing 30,000 monthly copies to our community most-trusted news source for our community Good News • Real News • Your Hometown News Designed by Elegant Themes | Powered by WordPress The 38 Best Tacos in Los Angeles The Best Barbecue Restaurants in Los Angeles, According to Eater Editors The Hottest New Restaurants in Los Angeles There are few more satisfying starts to the day than a delicious breakfast burrito each is its own unique LA offering meant to kick the morning off on a delicious note And while the ingredients usually stick to a familiar rhythm from bean-laden options in Malibu to chorizo-filled burritos in San Pedro Here is a collection of must-try breakfast burritos in Los Angeles known to Malibu locals and travelers alike for its filling morning breakfast burritos with lots of cheese and A post shared by Alexis EATS (@alexisl.eats) 26 of the Best LA Breakfast Restaurants by Neighborhood Sunny Venice star Great White is all about the Australian influences in its menu from flat whites to summery lunchtime bowls 19 Award-Worthy Cocktail Spots in Los Angeles 17 Places to Win the Fried Chicken Sandwich Wars in Los Angeles The lines form early at this Mission Hills pop-up Wednesday to Saturday at least — is a sellout at this unassuming sidewalk stand even though ownership sets up shop at 6:30 a.m The steak burrito is the classic on the menu but real ones know to opt for the chilaquiles burrito and add extra meat A post shared by Big Art's Tacos y Burros (@bigartstacos) Sobuneh has transformed from a pre-order-only burrito spot to a fully established breakfast spot running out of Colony Cooks Crowds flock here for the signature breakfast burrito that comes with scrambled eggs A post shared by Sobuneh (@sobunehla) The weekend breakfast burritos at this do-it-all South Bay destination are more than a hit: they’re a sensation Hundreds of burritos sell each Saturday and Sunday as is the addition of just enough green onion 12 New Year’s Eve Spots in LA That Are Worth the Headache Redondo Beach can’t get enough of Phanny’s the seaside option that’s been fueling up surfers and beachgoers for years It’s not hard to see why given the massive quantities and big flavors of Phanny’s breakfast burrito offerings 20 Amazing Takeout Meals in LA and All the Nearby Picnic Spots to Enjoy Them 19 South Bay Restaurants to Explore While Social Distancing in LA The Rooster is the first standalone restaurant from Rouha Sadighi customers can snag a Rico Suave breakfast burrito with tater tots and avocado every day from a single location instead of chasing Sadighi’s truck all over the city A post shared by The Rooster Truck (@theroostertruck) on Sep 20 The 8 Top Restaurants Near Hamilton Pool Preserve The most famous creation at Fairfax hotspot Cofax is undoubtedly the breakfast burrito a near-legendary affair that can be served vegetarian or with a collection of possible meats The quintessential order is the chorizo burrito with the addition of avocado the latter ingredient giving an extra layer of creaminess to balance the crisp tortilla seal A post shared by Cofax Coffee (@cofaxcoffee) on Oct 12 The Essential Guide to Fairfax Restaurants 51 Standard-Bearing Los Angeles Coffee Bars Humberto “the Chori-Man Raygoza has come a long way from when he started selling chorizo door to door off a cooler in 2013 Now with a permanent shop in the heart of San Pedro it’s possible to get some of the best chorizo in greater Los Angeles by the pound The classic Chori-Man breakfast burrito comes with crispy potatoes El Jalapeno is making some of the best breakfast burritos around Look for the chicken giving a thumbs-up to find the restaurant which is a small building with two windows and an outdoor seating area Order the breakfast burrito with chorizo and make sure to top each bite with the spicy hot sauce that comes on the side Cafe Los Feliz is a breakfast burrito veteran from way back the small cafe on Hillhurst was doing soujuk breakfast burritos well before any other modern competitor and potato version remains the best option here A post shared by Cafe Los Feliz (@cafe_losfeliz) Settle into a booth at this sun-soaked Silver Lake spot for the ADB Breakfast Burrito 2.0 which comes with smoked longaniza sausage Avocado is available as well for an additional cost The breakfast burrito is available until 4 p.m so there’s no need to rush over first thing in the morning A post shared by All Day Baby (@alldaybabyla) 20 Seriously Decadent Breakfast Sandwiches in Los Angeles Sidle Up to the Bar at These 14 LA Restaurants the breakfast burrito at Doubting Thomas is a masterpiece of a meal A post shared by DOUBTING THOMAS (@doubtingthomasla) on Oct 24 Everyone loves Tacos Villa Corona in Atwater Village That’s why weekend sidewalk waits can sometimes stretch to an hour or more though most hangers-on agree the time spent salivating at the simple a.m burritos — including the unadorned papas and chilaquiles burritos and the nopales burrito stuffed with spinach and cheese — is ultimately more than worth it A post shared by Tacos Villa Corona (@tvcatwater) Wake & Late is meant for all morning commuters — even if it is available throughout the day cheesy eggs and tater tot base really set this one up for success no matter what a diner might throw at it making this Downtown walk-up one of the best places for a burrito anywhere in Southern California The breakfast burritos are also available at the second location in Pasadena There are many things to like about Guerrilla Cafecito’s breakfast burritos just-firm-enough eggs that provide much-needed lift to the burritos without being soggy or runny It all blends together best in the chorizo and potato version A post shared by Guerrilla Cafecito (@guerrillacafecito) The breakfast burrito at Macheen’s residency inside of Milpa Grille in Boyle Heights has developed something of a cult following thanks to its technique-forward design with soft-scrambled eggs A post shared by Macheen (@_macheen_) The 17 Essential Restaurants on the Eastside of Los Angeles Enduring Highland Park restaurant Jugos Azteca serves a simple and affordable breakfast burrito A chile relleno version stuffed with a poblano pepper is available as well make sure to try one of the fresh juices off the menu A post shared by LosAngelesFoodCritics (@losangelesfoodcritics) Though La Azteca may be better known for its non-breakfast options the breakfast burrito at this East Los Angeles tortilleria packs a punch order the chile relleno and add a fried egg The itinerant traveler counted LA as one of his favorite cities in the world Despite the sunshine, the slow pace of the sidewalk crowds, and all that sprawl, Anthony Bourdain always kept a little love in his heart for Los Angeles. The iconic chef, writer, television host, traveler, and beloved-by-everyone media figure died this morning in France at the age of 61 Below, Eater has compiled a few kind recollections that Bourdain shared about his time in Los Angeles, from staying at the Chateau Marmont to eating at his favorite fast-food restaurant He really did love In-N-Out: It’s no secret that Bourdain had a thing for In-N-Out. In fact, he often described it as among the only fast food he would eat, period, and certainly at the top of his list. Here he is in 2015 describing just how wonderful those burgers are And LA’s Mexican food: Last year, Bourdain sat down with chef Eduardo Ruiz of the shuttered Corazon y Miel to discuss modern Mexican food in Los Angeles. The group dined happily at Ray Garcia’s Broken Spanish in Downtown, discussing the flavors of Los Angeles and what makes Mexican food so vibrant On the same show Bourdain managed to take in large swaths of LA’s immigrant communities The Parts Unknown season premiere from 2017 offered a ton of gorgeous pull quotes That includes the small spots: Perhaps no Los Angeles restaurant has been better helped by Anthony Bourdain’s mere presence than Tacos Villa Corona in Atwater Village. The tiny takeaway window almost immediately became nationally known after Bourdain showed up for a sidewalk burrito way back in 2012 Respecting immigrant workers in the kitchens and the fields: Bourdain was never one to hold his tongue, particularly in the wake of the 2016 election of President Donald Trump. In an Eater interview given just before Trump officially took office Bourdain had this to say about the now-president’s racist policies toward immigrants: But if I can convince people to look around and see who’s actually doing a lot of the work in this country — picking vegetables it’s all immigrant labor — and then ask themselves whether they under any circumstances would take that job Koreatown was a favorite haunt: Koreatown feels almost tailor-made for a man like Anthony Bourdain. Filled with warrens of hidden restaurants and all-night dining and drinking dens, the LA neighborhood quickly became one of the TV personality’s favorite places to take his cameras And most recently, he ate everywhere else in LA: Just last month, Bourdain and the Parts Unknown crew dropped a series of Los Angeles-based vignettes. The small episodes were meant to capture the lesser-known immigrant communities of Los Angeles from Little Armenia to the LASA guys cooking Filipino food in Chinatown Bourdain kept a lot of love for (and gave a lot of life-changing screen time to) Los Angeles If you or anyone you know is considering suicide or self-harm or is anxious, depressed, upset, or needs to talk, call the National Suicide Prevention Hotline at 1-800-273-8255 or text the Crisis Text Line at 741-741. For international resources, here is a good place to begin Metrics details SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic we investigated the interaction of this new coronavirus with Vero cells using high resolution scanning electron microscopy the interior of infected cells and the distribution of viral particles in both environments were observed 2 and 48 h after infection and viral interactions with the cell surface Intercellular connections were also approached and viral particles were adhered to these extensions suggesting direct cell-to-cell transmission of SARS-CoV-2 Understanding the virus-cell interactions is key to vaccines Most microscopic studies of SARS-CoV-2 were performed with transmission electron microscopy we used high resolution scanning electron microscopy (SEM) to study inner cellular structures The results offer evidence of infection-induced cellular remodeling and the formation of a specialized region for viral morphogenesis We also show intercellular extensions for viral cell surfing These observations offer new insights into the transmission of SARS-CoV-2 SARS-CoV-2 isolate (HIAE-02: SARS-CoV-2/SP02/human/2020/BRA (GenBank accession number MT126808.1) was used in this work The virus was grown in Vero cells (Monkey African Green kidney cell line – ATCC CCL-81) in the Laboratory of Molecular Virology Vero cells were maintained in DMEM supplemented with 5% fetal bovine serum (FBS; GIBCO) at 37 °C and 5% CO2 All work involving infectious SARS-CoV2 was performed in a biosafety level (BSL)-3 containment laboratory Semi-confluent (70%) cells were grown on sterile glass coverslips in 24-well tissue culture plates infected with MOI (multiplicity of infection – the rate of virus per cell) values of 0.01 or 1 using SARS-CoV-2 in free-serum medium Fresh medium containing 5% FBS was added after an absorption period of 1.5 h at 37 °C and 5% CO2 Cells were processed for electron microscopy 2 or 48 h post-infection (hpi) This technique does not totally remove the plasma membrane as happens when detergent extraction is used but provides the exposing of large areas of the inner portion of the cells They were then sputtered with a 5-nm thick platinum coat in a BALZERS apparatus Samples were observed using an Auriga ZEISS microscope operated between 1.0 and 1.8 kV Effect of SARS-CoV-2 infection on host cell surface at 2 and 48 hpi mock-infected cells exhibited smooth surfaces (A) while infected cells presented a discreet increment in the number of SP with the MOIs of 0.01 (B) and 1 (C) No viral particles were observed on the surface of infected cells at 2hpi (E) Mock-infected cell surface at 48 h (F) Virus adhesion to the cell surface and SP (arrowheads) became more evident with the MOI of 0.1 (F) C) 2 µm; (B) 10 µm; (D) 1 µm; (E Morphology of cells surface and interior at 48 hpi (B) Spikes of SARS-CoV-2 particles observed on the cell surface were discernible (MOI of 0.1) Viruses observed on cell surface (cs) exhibited a size between 70 and 85 nm (B Scraping of cells plasma membrane (D) revealed a homogeneous distribution of organelles in mock-infected samples Infected cells exhibited coated pits vesicles of ≃ 100 nm (arrows) at perinuclear sites (E) A polarized disposal at the infected cells cytosol (F) represented as a condensed area (ca) in the infected ones (MOI of 0.1) E) 100 nm; (B) 20 nm; (D) 2 µm; (F) 1 µm Inspection of the condensed areas of cells at 48 hpi (A) Profusion of vacuoles (arrowheads) in cells infected with the MOI of 1 The possible route of the vacuoles was indicated by arrows in (B) Scraped vacuoles had at least part of their content exposed Vacuoles in (C) and (D) presented doughnut-like particles (arrows) borderinng vesicles (arrowheads) could be recognized next the vacuole membrane Vacuoles shown in (E) display doughnut-like particles (arrow) and immature viral-like particles (arrowhead) too Fate of the SARS-CoV-2 particles adhered to the cell surface at 48 hpi B) Cell membrane ruffles about to wrap several viral particles (arrows) Viruses could also be observed on the edge of membrane ruffles (arrowheads) (A) and phyllopodium-like extensions (B) In (C) a viral particle could be seen adhered to the edge of the microvilli-like structure (arrow) next to membrane ruffles (long arrow) surrounding SARS-CoV-2 particles (arrowheads) (D) Communications between two infected cells are indicated with arrowheads One of the bridges between the cells was depicted in the rectangle A higher magnification of this area is shown in (E) and displays viral particles (arrows) on their surface Aggregates of SARS-CoV-2 particles (arrowheads) were also observed on the surface of both cells This microscopic approach detailed virus-induced changes in the cell Our assays were performed using three MOIs (0.01; 0.1 and 1) and we could discern the MOI of 0.1 as the more adequate for this type of study This MOI allowed the best cell conditions and distribution and also allowed visualization of virions through the cell surface into the cell interior and thus we speculate that their role in viral pre-components leads to discharge into the compartments Studies with other coronaviruses identified large virion-containing vacuoles (LVCVs) where the complete particle would bud There is correlation between these structures as observed by transmission electron microscopy and our data suggesting the occurrence of both phenomena our observations suggest that a boost in vacuoles is restricted only to a specific and more condensed part of the cytoplasm This suggests translocation to the plasma membrane is required for release the viral particles by a fusion mechanism This mechanism is presumed to allow the in vivo penetration of virus in mucosal surfaces that display microvilli-rich cells virus cell surfing was shown on SARS-CoV-2 infection which offers new insights into cell-to-cell propagation and virus transmission A novel coronavirus from patients with pneumonia in China A new coronavirus associated with humanrespiratory disease in China World Health Organization. Coronavirus disease (COVID-19) pandemic https://www.who.int/emergencies/diseases/novel-coronavirus-2019 (2020) and antigenicity of the SARS-CoV-2 spike glycoprotein A pneumonia outbreak associated with a new coronavirus of probable bat origin Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus Structure of SARS coronavirus spike receptor-binding domain complexed with receptor Structural analysis of major species barriers between humans and palm civets for severe acute respiratory syndrome coronavirus infections Coronaviruses: an overview of their replication and pathogenesis Virus factories: associations of cell organelles for viral replication and morphogenesis Modification of intracellular membrane structures for virus replication Molecular interactions in the assembly of coronaviruses SARS-coronavirus replication is supported by a reticulovesicular network of modified endoplasmic reticulum Coronaviruses post-SARS: update on replication and pathogenesis Diagnosing COVID-19: the disease and tools for detection Microscopy analysis of Zika virus morphogenesis in mammalian cells The strengths of scanning electron microscopy in deciphering SARS-CoV-2 infectious cycle SARS-CoV replication and pathogenesis in an in vitro model of the human conducting airway epithelium Identification of coronavirus isolated from a patient in Korea with COVID-19 Transmission electron microscopy imaging of SARS-CoV-2 Electron microscopy of human immunodeficiency virus Herpes simplex virus-induced cell surface protrusions Role for the Vaccinia virus A36R outer envelope protein in the formation of virus-tipped actin-containing microvilli and cell-to-cell virus spread Influenza virus budding from the tips of cellular microvilli in differentiated human airway epithelial cells Topographic changes in SARS coronavirus–infected cells during late stages of infection Early events of SARS coronavirus infection in Vero cells The global phosphorylation landscape of SARS-CoV-2 infection A structural analysis of the natural egress of Toxoplasma gondii New advances in scanning microscopy and its application to study parasitic protozoa Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus The life cycle of SARS coronavirus in Vero E6 cells Qualitative and quantitative ultrastructural analysis of the membrane rearrangements induced by coronavirus Ultrastructural characterization of membrane rearrangements induced by Porcine Epidemic Diarrhea Virus infection Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells Human Metapneumovirus induces reorganization of the actin cytoskeleton for direct cell-to-cell spread Morphogenesis and release of fowlpox virus Actin filaments participate in West Nile (Sarafend) virus maturation process Cryo electron tomography of native HIV-1 budding sites Actin dynamics in host-pathogen interaction Bridging the gap: virus long-distance spread via tunneling nanotubes Download references We thank Professor Kildare Miranda (CENABIO) for providing the microscopy facilities; Dr Lorian Cobra Straker (CENABIO) and Flávio Augusto Ferreira Martins Bezerra (INMETRO) for technical assistance This work has been supported by Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro-FAPERJ Financiadora de Estudos e Projetos-FINEP and Conselho Nacional de Desenvolvimento Científico e Tecnológico-CNPq Present address: Núcleo Multidisciplinar de Pesquisa UFRJ-Xerém em Biologia – NUMPEX-BIO Laboratório de Ultraestrutura Celular Hertha Meyer Instituto de Biofísica Carlos Chagas Filho Lucio Ayres Caldas & Wanderley de Souza Gustavo Peixoto da Silva & Luciana Jesus da Costa Instituto Nacional de Ciência e Tecnologia de Biologia Estrutural e Bioimagem Núcleo Multidisciplinar de Pesquisa UFRJ-Xerém em Biologia – NUMPEX-BIO Isolate preparations and virus growth were conducted by G.P.S Sample preparations and microscopy analysis were performed by L.A.C and F.A.C.; analysis of the results was performed by L.A.C. contributed to the initial conception and design of this work The first draft of the manuscript was written by L.A.C commented on previous versions of the manuscript All the authors were involved in reviewing and editing the manuscript All authors read and approved the final manuscript Download citation DOI: https://doi.org/10.1038/s41598-020-73162-5 Anthony Bourdain may have been a ride-or-die New Yorker but that doesn't mean he was immune to the allure of Los Angeles He featured the city on several television shows he hosted including "A Cook's Tour," "No Reservations," "The Layover," and "Parts Unknown." On each episode Bourdain shone a spotlight on some of his favorite restaurants He also enlisted special guests to take him to some of their favorite eateries many of which he immediately took a liking to Based on those shows and interviews the chef did with various media outlets we have a clear picture of the restaurants Bourdain loved in L.A All that mattered to Bourdain was whether the food was truly good If you're planning a trip to the City of Angels and want to eat some seriously good grub these are some of the restaurants in Los Angeles that Bourdain thought were a step above the rest Anthony Bourdain visited Los Angeles twice for CNN's "Parts Unknown." In the first episode, he explored several spots in Koreatown. In the second episode are a vital part of us." One of the first spots he visited on that episode was Gish Bac a restaurant specializing in cuisine from Oaxaca Gish Bac serves a variety of traditional Mexican dishes but the house specialties are mole negro and barbacoa Mole negro is a complex sauce that typically includes roughly 30 ingredients very deep." Barbacoa typically features lamb or goat slow-cooked until the meat is falling apart The family that runs Gish Bac hails from Oaxaca and draws on generations of experience cooking these dishes so it doesn't get much more authentic than that instagram.com/gishbac/ the celebrity chef gushed about a meal he had there with the Queens of the Stone Age crew Bourdain's meal at Chi Spacca consisted of salumi he had to indulge in some of the meats the restaurant is famous for He tried a beef and marrow pie that he said "flooded my head with awesomeness." The dish that impressed him the most though was a massive bone-in Fiorentina steak You can still find many of those dishes on the menu today chispacca.com and one that impressed him in Los Angeles was The Prince the bar originally opened as The Windsor in 1949 The grand interiors caught the eye of movie talent scouts and the spot would go on to feature in films like "Chinatown" and "The Woman in Red." When Korean owners took over in the 1990s they revamped the menu to include Korean dishes but kept the original old-school decor instagram.com/theprincela/ Tail O' the Pup is a retro hot dog stand that's shaped like a giant hot dog Sidle up to the counter and you have your choice of all-beef or veggie hot dogs with a variety of toppings Bourdain went for a chili cheese dog with tomatoes tailothepup.com While exploring some of Los Angeles' most iconic Mexican eateries on "Parts Unknown," Bourdain enjoyed a seafood feast at Mariscos Chente with a crew of mixed martial arts fighters a heaping plate of camarones borrachos (drunken shrimp) The dish featured whole shrimp (minus the tails) sauteed in garlic and butter over high heat The dish was finished with a sprinkling of cilantro Mariscos Chente started as a backyard seafood joint at Vincent Cossio's family home in 1984 The family opened an official restaurant on Imperial Drive in 1987 and it quickly earned accolades for its flavorful Nayarit and Sinaloa-style seafood dishes the younger generation took over and rebranded the restaurant as Coni'Seafood The dishes are just as authentic and vibrant as the original Mariscos Chente so much so that Coni'Seafood has received a coveted Michelin Bib Gourmand award instagram.com/coniseafood/ If you're a meat lover like Bourdain was, it's pretty hard to pass up some good Korean barbecue. One of the chef's favorite KBBQ spots in Los Angeles was Park's BBQ. He told L.A. Weekly that every time he was in town he would visit the restaurant and that he brought several chef friends there Park's BBQ is all about premium meats like USDA Prime and Kobe-style beef that you can grill yourself at your table The meal typically starts with an array of appetizers called banchan like kimchi pancakes After whetting your appetite with the banchan you can grill up your choice of meats including galbi (prime beef shortribs) You can wash down your barbecue feast with Korean soju parksbbq.com "It's the only fast-food chain that I actually like and think is reasonably good for the world." The first In-N-Out hamburger stand opened in Baldwin Park It was a drive-thru spot where people could order their meals via a two-way speaker box and pick up their food without having to get out of their cars although you can also dine inside and outside at many In-N-Out locations Bourdain was a fan of the Double Double burger with two beef patties and cheese on a toasted bun which includes mustard-grilled burger patties in-n-out.com The dishes are not only delicious but also a testament to how deeply ingrained Mexican culture is in the culinary heritage of Los Angeles cielitolindo.org Anthony Bourdain may have spent over twenty years working as a chef in professional kitchens That may have been what attracted him to Musso & Frank a swanky restaurant and bar that first opened in 1919 and has attracted more than its fair share of Hollywood writers and actors over the past century it may just be the restaurant's timeless atmosphere and decadent dishes that drew Bourdain to the spot and kept him coming back time and again In an interview with Haute Living "a perfectly-preserved old-school Hollywood restaurant." He stated that he loved how the bartenders knew how to whip up perfect cocktails with no pretensions and that the menu featured classic steakhouse dishes When asked which dishes he would pair with his cocktails the chef said he would opt for tried-and-true favorites like the wedge salad It's not hard to picture Bourdain sipping a martini at the mahogany bar or tucking into a steak in one of the leather booths at this historic Hollywood spot mussoandfrank.com The second place Bourdain sought out on his quest for the perfect Angeleno hot dog on "A Cook's Tour" was Pink's Hot Dogs dog maker's art." This iconic hot stand has been slinging sausages since 1939 It started as a simple push-cart and transitioned to a brick-and-mortar shop in 1946 you'll likely find a line-up of hungry patrons under the pink awning waiting to get their fix of all-beef dogs dressed in an array of toppings Bourdain tried a variety of hot dogs on his visit to Pink's including the O.G chili cheese dog; the classic bacon dog; and a 12-inch jalapeño dog with guacamole Other imaginative dogs include the New York Dog with sweet and saucy onions and the Carl Reiner Dog with mustard and sauerkraut Bourdain was taken aback by the gluttony of toppings pinkshollywood.com The premise of the Travel Channel's show "The Layover" was to show people where to eat and drink if they only had a day or two in a given city One of the spots that Bourdain recommended in Los Angeles for a hearty breakfast was Tacos Villa Corona this small taco stand may be slightly out of the way if you're staying downtown but Bourdain said it's well worth the trip hole-in-the-wall — all the marks of quality," he said Tacos Villa Corona is renowned for its breakfast burritos that are packed with tasty ingredients like eggs, potatoes, chorizo, and beans. You can also go vegetarian with a nopales (cactus) breakfast burrito or add some crunch by packing your burrito with chilaquiles every day and typically serves through to lunch You may want to get there early though because the stand closes when the food runs out tacosvillacorona.net "My brain is still pleasantly deranged with endorphins." Bourdain wasn't the only one smitten with Night & Market Food & Wine named Yenbamroong one of the Best New Chefs of 2016 and the restaurant was nominated for a James Beard Award for Outstanding Wine Program in 2020 Yenbamroong has also expanded the restaurant to three locations across Los Angeles and one in Las Vegas The menus vary slightly but you can expect dishes like spicy salads Natural wines are also available at all locations nightmarketsong.com calling his meal "outstanding" and "maybe the best." Osteria Mozza is another venture by award-winning duo Nancy Silverton and Joe Bastianich The decor is sophisticated but inviting with high ceilings The focal point of the restaurant is the marble mozzarella bar where you can sample cheese-centric dishes like burrata with bacon and smoked buffalo mozzarella The main menu is just as enticing with dishes like pappardelle with rabbit ragu Be sure to save room for the rosemary olive oil cakes osteriamozza.com trejostacos.com This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page What’s your favorite meal to whip up in the morning wouldn’t it be great if you could get it all wrapped up in one A burrito is the perfect grab-and-go option to much on while you’re headed to work or just looking for a substantial way to cure you after a fun night out View this post on Instagram Mainly known for their coffee but decided that they had to bring their customers some breakfast variety so they went to launch their iconic breakfast burritos This burrito is known for its slow-cooked potatoes There are various options such as vegan burritos pastrami and even their impossible burritos which include chorizo View this post on Instagram This family-owned and operated business has three different locations around the Los Angeles area Villa Corona has several tasty burrito options such as vegan Their breakfast burrito wraps include eggs View this post on Instagram If you’re out running errands and crave a quick bite to eat Corner Cottage will certainly do the job A small take out restaurant offering breakfast burritos chicken and teriyaki bowls as well as hamburger specials You will get your money’s worth with this corner cottage View this post on Instagram Pico Pica Rico is known to be one of the most popular burrito joints in the Los Angeles area This Sherman Oaks eatery has some of the tastiest burritos offering chicken bacon and chorizo options stuffed with potatoes View this post on Instagram A popular local eatery that’s a big hit with many Los Angelenos La Azteca has several options to satisfy your palates such as a Ranchero burrito egg and Pico de Gallo burrito amongst many other savory options If you’re looking for a little variety in your diet you won’t want to miss this place View this post on Instagram Created by a group of friends who started by simply selling burritos to their friends Then next came a food stand; now they have one of the most popular burrito spots in Los Angeles and just opened a new location The steak and bacon breakfast burrito is one of their popular and tastiest meals They also have bacon and vegan options as well with plenty of sauces to top it off Burrito Bomba is certainly a tasty option to cleanse your burrito craving palate View this post on Instagram It’s not a silly pun from President Trump’s ‘Make America Great Again!’ It’s the slogan of The Rooster a food spot that welcomes its customers to feel at home One of their tastiest burritos is The Rico Suave The Rooster can get you up early to start your day with both a full stomach and a smile on your face View this post on Instagram organic from scratch ingredients with Sonoritas Tacos They offer plenty of fresh options such as chicken With such a large variety to choose from you won’t be stuck on what to eat View this post on Instagram This chef-inspired casual restaurant offers a build your own burrito from scratch with pasteurized raised eggs as well as the Captain Crunch and Chiquito which are their vegan options View this post on Instagram B&B stands by breakfast being the most important meal of the day They want you to have more than just a meal so they prepare the food with only the utmost fresh and quality ingredients Bread & Breakfast promises to bring you the ultimate breakfast burrito experience [Featured Image: @burritobomba] A Facebook post March 17 warned users to be careful when going to the gas station claimed gas pump handles help spread coronavirus "I just spoke with a friend who got called into an emergency meeting at his hospital," McDonald wrote "He said the virus is spreading quickly from gas pumps." The Facebook post has roughly 310,000 shares along with nearly 4,000 comments and 4,000 likes “I am a paramedic and understand how easily these viruses can spread through [everyday] objects,” McDonald told USA TODAY “This was just a couple things they mentioned the virus can spread through and people [are] not realizing it As a medical professional it’s my obligation to inform [the] public on things like this.” Other versions of the claim have appeared on social media and messaging apps. Some versions of the post named hospitals where the “emergency meeting” took place. One such message on WhatsApp attributed the claim to Galway Hospital in Ireland. "We’ve not issued any such advice," a spokesperson for Galway University Hospital told the Journal.ie on March 20 Snopes and Health Feedback investigated the claim and found it to be partly false Snopes explained: “Gas pumps are just one of many objects that multiple people commonly handle in similar fashion during the course of a day all of which pose varying degrees of risk.” The Centers for Disease Control  and Prevention maintains that person-to-person contact is the main method of transmission. The agency says “It may be possible that a person can get COVID-19 by touching a surface or object that has the virus on it and then touching their own mouth but this is not thought to be the main way the virus spreads.” Researchers can’t measure how many cases are contracted through contaminated surfaces Health Feedback said “SARS-CoV-2 can survive for multiple days on solid surfaces like plastic or stainless steel no scientific studies have investigated how many people contract the virus through contaminated surfaces compared to direct contact with droplets spread by coughing and sneezing.” Thursday, the CDC released research conducted on the Diamond Princess Cruise ship where there was a major COVID-19 outbreak in early February The research revealed the virus was detectable on surfaces after 17 days without disinfection: “SARS-CoV-2 RNA was identified on a variety of surfaces in cabins of both symptomatic and asymptomatic infected passengers up to 17 days after cabins were vacated on the Diamond Princess but before disinfection procedures had been conducted.” The researchers could not determine whether the contaminated surfaces led to transmissions of COVID-19 on the ship but advocated for further exploration More: Coronavirus genetic material stayed on surfaces for up to 17 days on Diamond Princess cruise, CDC says McDonald suggested people use gloves or a paper towel to handle gas pumps “Wear gloves or have a paper towel touch the pump and throw the napkin or gloves out before you get back in the car,” he wrote The executive director of the nonprofit Fuels Institute, John Eichberger, told Consumer Reports, “If consumers are really worried about touching a gas pump handle they can do what they do when they go to a grocery store and wipe down surfaces with disinfectant wipes when they need to touch something.” The WHO describes how contact with contaminated surfaces can lead to transmission: “Hands touch many surfaces and can pick up viruses the virus can enter your body and can make you sick.” The CDC stresses the importance of proper hand-washing to prevent transferring the virus from a public surface – such as a gas pump – to your body “Wash your hands often with soap and water for at least 20 seconds especially after you have been in a public place.”  We conclude the claim that the coronavirus is "spreading quickly from gas pumps" is PARTLY FALSE because some of the claim was not supported by our research Although the virus can spread from contact with droplets on surfaces there is no evidence to suggest it spreads quickly via gas pumps or hard surfaces in general person-to-person contact is the main method of transmission  The CDC and WHO offer guidance on proper hygiene and disinfection methods to minimize chances of exposure to the coronavirus Print The allure of Atwater Village lies not in the many restaurants and specialty stores that line Glendale Boulevard and the Sunday farmers market is a popular gathering place for the community It would be impossible to tackle everything on Glendale Boulevard in one afternoon starting on Larga and heading on a loop of Glendale Boulevard vintage lighting and outdoor furnishings by Brown Jordan Noon There are many places in the area for java, but we like Kaldi Coffee at 3147 Glendale Blvd. It’s a neighborhood favorite and a refuge for many Hollywood screenwriters. From there, head to Goodies at 3189 Glendale a new showroom that promises “Unique goods Nothing over $25.” Budget gifts include wooden bowls 12:30 p.m. Next door, at 3191 Glendale Blvd., is deKor designer Isabelle Dahlin’s hygge-centric showroom filled with an eclectic mix of rugs New inventory for the holidays includes palo santo kindling bundles handmade wreaths and Nepalese scarves in addition to fragrances A woman waits for her order at Hail Mary Pizza. (Lisa Boone ) 1 p.m. Stop for lunch at Hail Mary Pizza, at 3219 Glendale, chef David Wilcox’s casual eatery, which was previously Journeymen take a seat and enjoy the view of the boulevard while waiting for your pie (we can recommend the meatball-za ($16) the chard mozzarella and garlic pizza ($16) as well as chicken wings with carrots and blood-orange glaze ($12) All bread and dough is made on site as are the tempting stacks of chocolate rye brownies and salted chocolate chip cookies that line the counter Lisa Boone is a features writer for the Los Angeles Times. Since 2003, she has covered home design, gardening, parenting, houseplants, even youth sports. She is a native of Los Angeles. Travel & Experiences Lifestyle If breakfast burritos were a piece of clothing it would be your perfectly worn in sweatshirt that made you feel cozy and right there’s something so comforting about the all-in-one wrap that we keep going back to whenever we’re looking for a hearty meal (or maybe in the throes of a hangover) we’re #blessed that we can order them pretty much anywhere you go but the many options can be a bit overwhelming which is why we pulled together a list of places that are guaranteed to hit the spot here are 19 of the best breakfast burritos in Los Angeles Bonus: Most of the places serve breakfast burritos all day The Absolute Best Chicken Wings in Los Angeles The tacos at this Atwater spot may have been what attracted the late Anthony Bourdain here in 2012 for an episode of “The Layover” but it was the breakfast burritos that made him say I could eat this whole thing.” Just one bite of their breakfast burritos and you’ll understand what he meant but there is just something about the classic papa Walk-up to place order (available for takeout only) 3185 Glendale Blvd., Los Angeles, CA 90039; tacosvillacorona.net If you’ve ever indulged one too many glasses of Pinot (no judgement) and need something greasy and carb-y to soothe your soul This behemoth is well known in the Frogtown neighborhood where it’s located for its hangover curative properties Pro tip: leave out the meat and sub for their made-fresh-daily refried beans Take out and outdoor seating is also available Located in strip mall by Cal State University is this absolutely cozy restaurant that serves up some of the best breakfasts in town their vegetarian-friendly Earth Burrito that comes with eggs perfectly seasoned roasted red potatoes and cheese with a side of sour cream 9250 Reseda Blvd Ste 1 Northridge, CA 91324; emlesnorthridge.com This Historic Filipinotown coffeeshop is serving up some of the city’s best coffee and flavor-packed food in generous portions Like their Doubtless Burrito that comes stuffed with braised pork shoulder 2510 W Temple Street, Los Angeles, CA 90026; doubtingthomas.la When a burrito is named “Rico Suave,” you know it has to be good This not-too-big-not-too-small breakfast burrito definitely lives up to it name bacon and cheese but the twist that sets it apart from its peers is the crispy tator tots all orders must be placed through their website for pickup or delivery 8809 W Pico Blvd., Los Angeles, CA 90035; therooster.com would be complete without the iconic Lucky Boy breakfast burrito It is rumored they sell more than 250 breakfast burritos a day The burrito is roughly the size of a newborn (OK that might be a little dramatic but it’s not far off) and contains fluffy eggs because this one is not for puckish eaters Multiple locations; luckyboyburgers.com Don’t let the seemingly random combination of burger and sushi throw you off—this Northridge gem is a favorite amongst the local college crowd Their breakfast burrito has three options and all are delicious: your choice of veggies 9345 Reseda Blvd., Northridge, CA 91324; kingsgotsushi.com Amongst all the changes of Grand Central Market it’s great to see Jose Chiquito is still standing We suggest grabbing the veggie burrito that’s exploding with tasty ingredients like mushrooms cheese and avocado (and no it’s not extra) 317 S Broadway A-6, Los Angeles, CA 90013; josechiquitorestaurant.com greasy breakfast burrito then go with Mixto tomatillo salsa and cheese all wrapped in a whole wheat tortilla 2827 Hyperion Ave., Los Angeles, CA 90027; mixtomixto.com This java and breakfast focused spin-off of Guerrilla Tacos serves up coffee Their Brekkie burrito has fresh ingredients like bacon But it’s their avocado salsa that has us coming back for more 704 Mateo St Los Angeles, CA 90021; guerrillacafecito.com You can expect two things from this East Los Angeles mainstay: amazing food and long lines and what’s waiting for you is a variety of breakfast burritos like carne asada All of these are wrapped up with one of the best tortillas you will ever have that’s made fresh on site Tu Madre is shaking things up a bit with their breakfast burrito.. Their take on the city’s favorite way to start the day includes unexpected ingredients like truffle guacamole and the option to add honey sriracha fried chicken Multiple locations or tumadre.com Some of the best burritos in Los Angeles can be found tucked away in a Chevron gas station in the San Fernando Valley But don’t let its location fool you—Cilantro is serving up burritos with quality ingredients These guys are big on building burritos by customization and their choices of salsa are nothing to turn your nose up at 7214 Whitsett Ave., North Hollywood, CA 91605; cilantromexican.com Vegans and meat lovers alike can find common ground with Taco Vega’s vegan breakfast burrito—this flavor-packed wrap includes hearty and mouthwatering scrambled organic tofu migas 456 N Fairfax Ave., Los Angeles, CA 90036; tacovega.com Given the popularity of Cofax’s breakfast it begs the question—is it a coffee shop with breakfast burritos or a breakfast burrito shop with coffee you will want to sink your teeth into their tortilla wrapped beauties filled with bacon All washed down with their Stumptown cold brew 440 N Fairfax Ave., Los Angeles, CA 90036; cofaxcoffee.com The belle of the ball at Cactus tends to be the California burrito but people are sleeping on her under-appreciated sister Order through their website or call for takeout Multiple locations; cactustaqueriainc.com the Fully Loaded breakfast burrito from SaMo’s Oaxaca is for you This bold burrito contains a triple threat of meats (ham 1865 Lincoln Blvd Ste 5, Santa Monica, CA 90404; samosoaxaca.com This Boyle Heights-based pop-up elevates your typical burrito base of eggs hash browns and cheese with meats like birria longanisa and pork belly that lend an amazing great depth of flavor to your meal The attention to detail and perfect pairings of aiolis and salsa to each order makes for an incredible experience cashdrop.biz/macheen The culmination of refried beans and Filipino spicy longanisa makes this ADB breakfast burrito one you won’t want to miss smoky and flavorful homemade sauce that’s reminiscent of enchilada sauce and we’re talking next level cuisine here 3200 W Sunset Blvd, Los Angeles, CA 90026; alldaybabyla.com THE BEST SOUPS IN LOS ANGELES, FROM CLAM CHOWDER TO WONTON LAist is part of Southern California Public Radio While delicious breakfasts can come in all sorts of shapes and sizes there's something about the flavor-packed convenience of a well-made breakfast burrito that is truly magical From straightforward egg-cheese-potato-meat affairs to masterpieces loaded with house salsas tortilla-wrapped reasons to get you out of bed To help you start your day right—or any part of the day in some cases—here are our favorite breakfast burritos around town let us know your local heroes in the comment section Frank's breakfast burrito (Photo by Danny Jensen/LAist) Frank's For years before Cofax began gaining attention for their breakfast burrito further up Fairfax Frank's was turning out a hearty rendition of its own—and thankfully nothing has changed While cheerful Frank himself serves up some quality tacos at this small The tightly packed tortilla comes loaded with a balanced blend of egg chorizo or—the obvious choice—a mix of bacon It's served with a killer house-made green salsa and Frank's will hook you up with complimentary chips and salsa while you wait Tacos Villa Corona is located at 3185 Glendale Blvd If you're looking for a savory breakfast burrito casual American comfort food restaurant Poppy + Rose has a good one Their Rib Tips Breakfast Burrito is made with ribs Wash it down with a cold-pressed juice or a cup of their self-serve coffee Pasadena's Lucky Boy shops never disappoint when it comes to giving customers behemoth breakfast burritos While they're not reinventing the wheel here Pro-tip: ask to add avocado for an extra charge because you're from California and you can The Chorizo breakfast burrito (Photo courtesy of Tacos Tu Madre) Tacos Tu Madre A new contender to the breakfast burrito world this tiny and colorful spot is serving up a great quick breakfast option in Westwood where there aren't too many quality While Taco Tu Madre's gourmet taco options are solid their breakfast burrito options are worth the visit Order from the window of the brightly painted exterior and choose from the Veggie tater tots and kimchi (!); the Chorizo with tots guacamole and eggs; or for a twist the Pastrami with bacon The last two are served with a side of house red pepper aioli Take them to go or grab a small table outside or inside their cozy Breakfast done right at Astro Burger (Photo by Danny Jensen/LAist) Astro Burger Unless you work at neighboring Paramount Studios—or have a keen sixth sense for breakfast burritos awesome—you've probably blown by Astro Burger countless times on Melrose Or maybe you got confused by the "Burger" in the name don't pass up their delicious offering of a snugly wrapped tortilla Astro Burger is located at 5601 Melrose Ave La Azteca Tortilleria is located at 4538 E This Redondo Beach stalwart has been making mornings brighter with their breakfast burrito since 1982 these breakfast bombs come stuffed with egg salsa and your choice of potatoes or hash browns—though we strongly encourage you to go with the hash browns you can choose the always-reliable and popular bacon option or go veg with the vegetable rendition (onions It's also strongly advisable to add avocado And don't forget to grab a cup of Stumptown coffee to really get your day started right Phanny's is located at 1021 S Pacific Coast Hwy This no-frills Burbank spot has been winning over legions of fans with their breakfast burritos for years and the massive lines on weekends can attest to their enthusiasm What at first glance may seem a standard egg potato and meat combo wrapped in a tortilla takes on new meaning when you start to chow down the surprise of jalapeño and a deft griddle chop to mix all the ingredients together all while staying under $6 (unless of course you order extra meat) And the searingly hot house salsa is always a welcome addition Just remember: they're cash-only and the breakfast burritos are only served until 11 a.m Burger Factory does breakfast burritos right (Photo by Danny Jensen/LAist) Burger Factory Burger Factory may look like much—it's in a strip mall and has ridiculous cartoon paintings all over—but it can sure deliver a quality breakfast burrito This no-frills spot goes back to the basics and fills their extra-large burrito (seriously you could eat this lil log over two sittings) with your choice of sausage or bacon They don't skimp on the fillings and they also give you some solid salsa to go with it so you can save your money for an horchata to wash it down Burger Factory is located at 6050 Hollywood Blvd A pair of Brother's burritos (Photo courtesy of Brother's Burritos) Brother's Burritos beachside favorite gives you free reign to find your favorite breakfast-burrito combo offering 16 different suggested variations along with long lists of proteins Whether you go big with the Triple (tri-tip potato and Monterey jack) or keep it light with veggies and egg whites to maintain that beach bod but the fresh ingredients keep things light And they're all around $5 or $6 (unless you go crazy with the add-ons) Don't forget to grab all three house salsas if you want to mix up the heat levels while you chow down While this upscale brunch favorite may be thought by many as the place for amazing baked goods and dishes that require a knife and fork they also bring their A-game to their breakfast burritos It may be a touch more gourmet than most—and pricier at $12—but it's hard to argue with fluffy scrambled eggs Add Niman Ranch bacon or Peads & Barnetts sausage for an extra two bucks and you're golden that while you can request sour cream on the side modifications are "politely declined," so you better be ready for the works .st1{fill-rule:evenodd;clip-rule:evenodd;fill:#2a2a2a}By Christie Dedman | cdedman@al.comCHRISTIE DEDMAN/THE BIRMINGHAM NEWSSpotted a tearpad for Corona $10 mail in rebate forms when you purchase an $10 or more in meat or poultry You must include the UPC codes and the original cash register receipt If you spot them please don't take the whole tearpad -- LIMIT ONE REFUND PER HOUSEHOLD You will need the original form and mail it in by Oct Use of and/or registration on any portion of this site constitutes acceptance of our User Agreement, (updated 8/1/2024) and acknowledgement of our Privacy Policy, and Your Privacy Choices and Rights (updated 1/1/2025) © 2025 Advance Local Media LLC. All rights reserved (About Us) The material on this site may not be reproduced except with the prior written permission of Advance Local Community Rules apply to all content you upload or otherwise submit to this site YouTube's privacy policy is available here and YouTube's terms of service is available here Ad Choices Corona has launched its new ‘This Is Living’ global brand platform via Wieden+Kennedy Amsterdam The campaign taps into the universal desire for freedom the brand wants to inspire people to go outside and live more moments that matter VIEW THE LIME RITUAL SPOT VIEW THE FLOW SPOT Through original content featuring authentic voices from around the world, this new global brand platform reminds consumers to relax, enjoy life and live authentic moments with friends. In addition to ‘The Flow’, Corona’s signature way to enjoy its refreshing beer is brought to life through ‘Lime Ritual’, a mesmerizing 60-second film shot from the view of the lime. A series of 15-second product films that focus on the bottle have also been created, which leverage the unique transparency of the product using it to frame life moments that truly matter in a visually compelling way. The campaign’s out of home represents the new ‘This Is Living’ positioning with executions featuring both active and relaxed moments, and which aim to serve as a mini-vacation from normal life for the viewer. The executions will run as outdoor, print and online, in addition to underpinning a comprehensive new social media strategy for the brand. Says Mark Bernath, executive creative director at Wieden+Kennedy Amsterdam: “Corona’s new creative positioning is an evolution of the brand’s iconic style – it’s still visually guided by the beach as it has always been, only now we are bringing more meaning to the reasons to go there. This is living is the articulation of that feeling we have when we find ourselves in awe of where we are. Our feet in the sand. A Corona in our hand. And space to breathe.” In the coming months the campaign will roll out in the United Kingdom, Europe, South America, Asia Pacific and North America (excl. USA). Marcel Marcondes: Global Marketing Vice President Thiago Zanettini: Global Marketing Director Clarissa Pantoja: Global Communications Director Executive Creative Director: Mark Bernath, Eric Quennoy Creative Director: Alvaro Sotomayer, Thierry Albert Head of Broadcast Production: Joe Togneri Director of Interactive Production: Kelsie van Deman Broadcast Producer: Kimia Farshidzad, Javier Perroud, Maud Klarenbeek, Stacey Prudden Account Manager    Jorge Papa, Jasmina Almeda, Alex Scaros Business Affairs: Michael Graves, Emilie Douque Production Company – Lime Ritual TVC: Park Pictures Production Company – The Flow TVC: Friend, London Artist / Title: Khruangbin “The Number 4” Photographer: Morgan Maassen, Vava Ribeiro Production Company: AM MARTINEZ FILMES,  SUPERVISION NEW YORK Producer: Anna Martinez (AM MARTINEZ FILMES), Rebecca McCubbin (Supervision) Watching multimillionaire Snoop Dog in designers clothing, at a resort, does not a lot of good to market Corona to common Americans. Hey this is nice and all, but I’m at a loss as to why you’d bin all the equity that’s been built-up in “from where you’d rather be”. Which seemed perfectly fine to me. Give me, “From Where You’d Rather Be” any day. Is it just me or would it be easy to take out the Corona bottle and put in a Coke bottle? from Patts, 1994 wanna add to the comments? Cognitive Disonance is right, it’s just so effing generic. YOLO, one life live it, this is life blah blah blah Register for Free and receive the Campaign Brief Daily Bulletin. Type your email address in the space below. From fancy places to hole-in-the-wall spots These restaurants aren’t just about the food; they’re a taste of the real America picked by a guy who traveled the globe searching for amazing meals From New York delis to Miami seafood spots Chef Creole Seasoned Kitchen was featured in Bourdain’s show, No Reservations. Bourdaincame to the restaurant with his fellow chef, Michelle Lindsay. Together with Chef Creole’s veryown Ken Pierre they had a delicious feast of spicy fresh conch chowder with sweet and greenplantains and grilled snapper with scotch bonnet.Lucky for you in addition to the Miami branch thatBourdain visited Give it a try and indulge in Ken Pierre’s Haitian menu Before becoming one of Bourdain’s favorite seafood restaurants, Captain Jim’s Seafood was afish distribution center When the owners saw that people were looking for a seafood restaurantin North Miami they decided to cater to this demand and opened up the restaurant.If you want to try what Bourdain got Try out some of their signature dishes which includes The Captain’s Tail Sandwichwhich is a fresh snapper fillet Also try out the Corvina Frances–a sea bass prepared with a lightlemon sauce over linguine Heidelberg Restaurant is a German restaurant in New York City where Bourdain was seenenjoying a pork shank and a beer. Bourdain described the pork shank as “tender, delicious,falling off the freaking bone.” The Heidelberg is also one of the oldest German restaurants in theUnited States with their menu dating back from when they first started if you want a taste ofGerman cuisine without going to Germany head on over here and try some of their sausageswith sauerkraut red cabbage and potato–which Bourdain also had Swan Oyster Depot’s menu is over a hundred years old and it was what Bourdain called as his“happy zone.” It was a regular hangout spot for him where he would come to film every time hewas in the Bay Area He described it as a crucial part of his global travels and expressedcontentment at the idea of dying at the counter of this beloved restaurant Russ & Daughters boasts one of Bourdain’s quotes where he says, “Russ & Daughtersoccupies that rare and tiny place on the mountaintop reserved for those who are not just theoldest and the last but also the best.” This century-old restaurant in New York City has beenserving pickled herring Anthony Bourdain loved Jitlada, a popular Thai restaurant in East Hollywood, Los Angeles.Known for its spicy Southern Thai cuisine and unique decor, Jitlada is a favorite for many foodenthusiasts Bourdain praised dishes like the crispy catfish salad which has a crunchy textureand fresh mango flavors His visits to Jitlada showcased hisappreciation for flavorful and high-quality meals reflecting his passion for exploring diverseculinary scenes in his travel and food shows Franklin Barbecue’s dedication to quality and the art of smoking meat drew Bourdain to theeatery The eatery is famous for the “Holy Trinity” of Texas barbecue: brisket all expertly prepared and highly sought after one of the bestpitmasters in the United States has an uncommon dedication that translates to long lines ofavid food consumers waiting daily He is also known for his meticulous attention to quality andhands-on approach personally slicing the meat despite the high volume of customers Featured in Bourdain’s show The Layover, Northern China Eatery is a “stairway to heaven”according to Bourdain This restaurant aims to serve freshest and most authentic food fromNortheast China and Beijin-Tianjin Bourdain’s personal recommendation is the fish in hot and spicy pot which is deepfried fish with loads of chili The Official Fast Food Club. 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