Don’t Miss a Single Sparkling Moment! Sign up for The Court Jeweller Newsletter The Court Jeweller Sparkling Royal Jewels From Around the World 04.29.2025 by // Leave a Comment as the Dutch royals headed to Doetinchem for the annual King’s Day celebrations King Willem-Alexander and Queen Máxima arrived in Doetinchem for the King’s Day festivities on Saturday The holiday is usually celebrated on the King’s birthday but because that fell on a Sunday this year (This is why no members of the main line of the Dutch royal family attended the Pope’s funeral They publicly expressed their regrets at the scheduling conflict The King and Queen were joined by their two eldest daughters the Princess of Orange and Princess Alexia (Princess Ariane is away studying at the United World College of the Adriatic.) Also present were the King’s brother and sister-in-law Prince Constantijn and Princess Laurentien as well as four of his cousins and their wives: Prince Maurits and Princess Marilène Prince Pieter-Christiaan and Princess Anita King’s Day is always a delightfully lively day, with plenty of games and music and fun. For the occasion while Princess Amalia chose a Ralph Lauren cape dress and Princess Alexia wore an ensemble from Maje and Massimo Dutti With her royal blue top, skirt, and hat, Máxima wore some gorgeous blue gemstone jewelry. Her earrings, which come from the family vaults, feature diamond and sapphire cluster studs and bright blue sapphire drops. These can be worn in different configurations The cluster stud is often worn with the family’s Sapphire Figure Eight Earrings while the sapphire drops have sometimes been worn with long diamond pendant earrings from the family collection Máxima also wore the diamond and tanzanite cluster ring from her personal collection on her right hand She wore her engagement and wedding rings on her left hand plus bracelets on both wrists: a gold charm bracelet on her left and her cabochon family bracelet on her right Princess Amalia wore a pair of on-trend chunky gold hoop earrings with her cornflower blue dress. She’s quickly proving that she’s inherited her mother’s ability to wear big jewelry pieces effortlessly. Per UFO No More she also wore a hand chain on her left hand Amalia’s also following in her mother’s footsteps by stacking her bracelets including a bangle with the letter A on one of its tips as well as a bracelet spelling out her name The ring on her right hand has been in her collection for several years It’s set with white and blue-green stones Alexia wore a mix of pieces from her own jewelry box (her diamond smiley face necklace her bracelets) and jewelry borrowed from her mother for the King’s Day celebrations Her earrings and the cocktail ring on her left hand are all from Roberto Coin an Italian jewelry brand founded in the 1970s are set with diamonds and red enamel in a pattern mimicking scales Categories // Netherlands Enter your name and email address below to subscribe to our weekly newsletter Sign up for my new subscriber-supported community, Hidden Gems, delivered directly to you each Saturday! Copyright © 2025 THE COURT JEWELLER LLC The Dutch royal family arrived in Doetinchem around noon Saturday to begin King’s Day celebrations following a morning marked by reflection on the death of Pope Francis The festivities in Doetinchem started more than an hour later than originally scheduled to accommodate the funeral of Pope Francis King Willem-Alexander addressed the nation with a rare video message broadcast on NPO 1 he reflected on the significance of the day describing it as “a day with two faces” because of the funeral "The community spirit of Pope Francis is also a hallmark of King’s Day," the King said He praised the late pontiff as "a man who embraced everyone through his faith," and said the Pope was able to touch "the heart of what truly matters in life: love The King emphasized that the spirit of community was more vital than ever "That’s why we find it very valuable to be here today," he said "This is even more important in this time of tensions and uncertainties in the world around us." He called on people to recognize that "freedom and legal certainty are not self-evident" and stressed they require "the active commitment of each of us." as King Willem-Alexander had previously addressed the nation on King’s Day only during the coronavirus pandemic A photo shared on Instagram by the royal household captured King Willem-Alexander and Princess Alexia just before their departure from their hotel the youngest daughter of the King and Queen Queen Máxima had earlier announced that Ariane could not attend due to her exam commitments at the United World College Adriatic in Italy as well as the route the royal family will take through the city on April 26 Mayor of Doetinchem Mark Boumans presented the programme for King’s Day after riding into the hall on an electric moped because it has to remain exciting until the day itself," Boumans told Omroep Gelderland What has been revealed is that King Willem-Alexander and his family will cover a route of 700 metres, stopping at multiple city attractions under the theme of tradition and innovation The royal bus will also be accompanied by electric mopeds to show off the innovation of the Achterhoek region Moped manufacturer Niels Willems will also have some mopeds waiting for the royal family to climb on "I hope of course that the king will jump on it But we do think it's nice that we can contribute to King's Day," said Willems Achterhoek band Normaal will welcome the king and his family will perform the song De Overkant at the festival as a tribute to the region “We can’t wait to play at a place that feels like coming home to us,” the duo said in a video message To see more of the King’s Day programme, visit the Doetinchem website Thumb image credit: Jannissimo / Shutterstock.com BookmarkSimone JacobsEditor at IamExpat Media ©2025 SBG Companies Limited or its affiliated companies, All rights reserved. 2025 King's Day is a Saturday this year Photo: DutchNews.nlThe funeral of pope Francis in Rome on Saturday has led to changes in this year’s King’s Day celebrations in Doetinchem but the king and queen will not attend the service the state information service has confirmed Prime minister Dick Schoof and foreign minister Caspar Veldkamp will represent the Netherlands at the funeral of the pontiff There had been speculation that the king and/or queen Máxima might cancel their King’s Day plans to travel to the Vatican and Máxima is both Argentine and Catholic by birth the Doetinchem festivities will start at midday rather than 11 am when the live television broadcast of the funeral will also begin the Netherlands has always been represented by the prime minister France’s Emmanuel Macron and Ukraine’s Volodymyr Zelensky are among the world leaders to have confirmed their attendance at the funeral We could not provide the Dutch News service without the generous support of our readers Your donations allow us to report on issues you tell us matter and provide you with a summary of the most important Dutch news each day Many thanks to everyone who has donated to DutchNews.nl in recent days We could not provide this service without you Please help us making DutchNews.nl a better read by taking part in a short survey "Here stands a very satisfied mayor," said Mark Boumans "Everything went exactly as we had hoped." "It was fantastic I have the impression the royal family enjoyed themselves too and I believe all the visitors in the city center had a great time." Boumans also noted that he planned to watch the national broadcast of the festivities again at a quieter time large crowds continued to gather in Doetinchem’s city center to keep the celebration going and long lines formed at bars and restaurants Local businesses took advantage of the occasion including a game store that released a special "King’s Day in Doetinchem" puzzle Many shop windows across the city were decorated in orange to mark the celebration Doetinchem’s streets were packed with people as thousands turned out to see the royal family Spectators waved flags and wore festive orange crowns as they lined the route of the royal procession Many stood several rows deep behind barriers and some climbed onto platforms to get a better view of King Willem-Alexander and his family as they passed by under clearing skies the celebrations extended into neighborhoods where homes were decorated with flags Children set up lemonade and baked goods stands outside their houses The official royal program concluded around 2 p.m where the mill’s sails were adorned with banners featuring the Dutch and Achterhoek flags transportation from Doetinchem remained orderly A spokesperson for Arriva said the platforms were full but that trains and buses remained manageable Extra trains and shuttle buses had been arranged to carry visitors back to parking lots outside the center Although it was unclear whether seats were available on all trains the exodus from the city proceeded smoothly with crowds moving steadily toward the station and shuttle buses Streets were left scattered with orange and red-white-blue flags after the festivities King Willem-Alexander and Queen Máxima were welcomed to Doetinchem earlier in the day by Mayor Boumans who expressed his happiness that the king chose to celebrate his birthday in the city The royal family’s visit included a musical performance by the band Normaal who played their hit "Oerend Hard." King Willem-Alexander and Prince Constantijn were seen singing and dancing along with the music Prince Constantijn later remarked that he enjoyed hearing music from his youth The royals also participated in various sporting activities during the visit King Willem-Alexander and Queen Máxima played a round of table tennis during which the king scored a point with a powerful smash Queen Máxima’s team eventually won the King's Day quiz which concluded with a round of penalty shots King Willem-Alexander missed his shot during the final Earlier in the day King Willem-Alexander recorded a video message acknowledging the death of Pope Francis He praised the pope’s community spirit and said it mirrored the spirit of King’s Day the king said the decision not to attend the pope’s funeral had been carefully considered over a long period Because the pope’s funeral took place in the morning the start of King’s Day festivities in Doetinchem was delayed King Willem-Alexander reportedly expressed his deep gratitude that the schedule had been adjusted He also thanked the many German visitors in Doetinchem delivering part of his farewell speech in German The Dutch Royal Family has released a heartwarming video from the celebration of King’s Day 2025 in Doetinchem and Princess Alexia attended the celebration The Palace’s announcement about the event read “His Majesty the King will attend the celebration of King's Day in Doetinchem in the province of Gelderland on Saturday with members of the Royal Family and members of the Royal Family.” King’s Day is the national holiday to celebrate the monarch’s birthday on April 27 “King Willem-Alexander attends the celebration of King's Day in Doetinchem with members of the Royal Family and members of the Royal Family.” Willem-Alexander also delivered a speech and thanked everyone for celebrating his big day the Achterhoek and Gelderland have shown here how you can create such an amazing King's Day by working together Prince Bernhard and Princess Annette were present and Princess Aimee also came in Doetinchem to celebrate King Willem’s 58th birthday This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Nienke Veenhoven third in crash-marred sprint into Doetinchem In a sprint that was marred by a crash on the final kilometre Wiebes outsprinted Elisa Balsamo (Lidl-Trek) and Nienke Veenhoven (Visma-Lease a Bike) Audrey De Keersmaeker (Lotto-Dstny) had animated the stage with a solo of more than 70km but the Belgian was caught 14km from the finish in Doetinchem Despite almost continuous attacks in the final the stage then came down to a sprint where Wiebes was the fastest.  Yellow jersey Franziska Koch just escaped the crash and keeps the overall lead going into Sunday's final stage As her teammate Lotte Kopecky was one of the crashed riders Wiebes had mixed feelings after her victory and Lotte said right away on the radio that she was on the ground It was a really dangerous final with all the traffic islands and when the peloton goes from left to right A crash happens fast in that situation,” said Wiebes “I did get out of position a little bit Kopecky’s crash ruined SD Worx-Protime’s plan for the sprint where the team wanted to get bonus seconds for the world champion in order to move her up in GC “Lotte should have been sitting on my wheel and tomorrow is a new day,” finished Wiebes the peloton stayed together until De Keersmaeker went solo with over 85km to go The 25-year-old Belgian quickly built a gap of over a minute and with 60km to go she was 2:45 minutes ahead De Keersmaeker switched her focus to road cycling in 2023 and signed for Lotto-Dstny for 2024 she won the stage 2 combativity prize with a solo breakaway and her exploits around Doetinchem would earn her the combativity prize and red jersey again The peloton sprang into action 55km from the line – not by picking up the chase but by launching attack after attack Visma-Lease a Bike and Liv-AlUla-Jayco were the most active while other teams also joined in SD Worx-Protime had their hands full covering all the moves but none of the attacks lasted long as they were either caught quickly or there was no cooperation if five or six riders (often with an SD Worx-Protime rider among them) got a small gap The higher speed reduced De Keersmaeker’s advantage to only 18 seconds with 41km to go increasing her gap to over 30 seconds again Linda Riedmann (Visma-Lease a Bike) attacked with 15km to go and finally bridged to De Keersmaekers; both were reeled in a kilometre later This set off another flurry of attacks with almost every Visma-Lease a Bike rider as well as Quinty Ton and Ruby Roseman-Gannon (both Liv-AlUla-Jayco) having a try and when SD Worx-Protime amassed at the front of the peloton six kilometres from the finish The sprint trains manoeuvred for the best positions going into the final kilometre where a touch of wheels brought down Kopecky and Charlotte Kool (DSM-Firmenich PostNL) also causing Karlijn Swinkels (UAE Team ADQ) and Marthe Truyen (both Fenix-Deceuninck) to go down Kool had to abandon while the others could finish the race Rachele Barbieri (DSM-Firmenich PostNL) went early down the right-hand side of the road with Lara Gillespie (UAE Team ADQ) and Ally Wollaston (AG Insurance-Soudal) on her wheel Wiebes launched her sprint on the left side of the finishing straight and passed Barbieri Balsamo came out of Wiebes’ slipstream on the final metres but could not pass her Results powered by FirstCycling Lukas Knöfler started working in cycling communications in 2013 and has seen the inside of the scene from many angles Having worked as press officer for teams and races and written for several online and print publications he has been Cyclingnews’ Women’s WorldTour correspondent since 2018 As Doetinchem prepares for a busy King’s Day celebration with the royal family’s visit reported that trains and buses to the city are bustling with travelers Extra trains have been deployed to accommodate the influx of people heading to the Achterhoek region "It’s pleasantly busy," an Arriva spokesperson said and we’ve been able to manage the crowd effectively." Those driving to Doetinchem can use shuttle buses from two special parking lots to reach the city center "Everything is going very well there too," the spokesperson continued and we’re able to handle the volume of people comfortably." Mayor Mark Boumans is eagerly anticipating the royal visit "It will be a beautiful and special day in the heart of the Achterhoek," Boumans said expressing his pride that the royal family had chosen Doetinchem to celebrate King Willem-Alexander’s birthday The mayor also took a moment to acknowledge the community’s efforts in preparing for the day "There are about 300,000 people in the Achterhoek," he noted "I think half of them are directly or indirectly involved in organizing the event." Boumans praised the collective spirit: "We’ve really pulled together to make this a success." This change was made in response to the funeral of Pope Francis "It’s a special development," Boumans admitted but the death of the Pope wasn’t part of our planning." Boumans emphasized the importance of being sensitive to the occasion "We’ve worked in close consultation with everyone involved to make sure we handle the situation in the best way possible," he said Maps of the six stages of the Simac Ladies Tour The 2024 Simac Ladies Tour will be held from October 8-13 in the Netherlands.  The route covers 708.1km kilometres across six days of racing, including one individual time trial. According to the organisers, the wind, bonus seconds, time trial kilometres and a selective final around Arnhem will determine the ranking and where tension seems guaranteed until the end. Join Cyclingnews' coverage of the 2024 Simac Ladies Tour with race reports, results, photo galleries, news and race analysis. The stage 1 winner will wear the first leader's jersey on Tuesday, October 8. Riders will cover a 10.1-kilometre time trial in the city centre of Gennep in Limburg. Stage 2 is a 159km route that begins in Coevorden for the longest day of the six, and heads north to Assen. Stage 3 is a 143km loop starting and ending in Zeewolde. Stage 4 is another loop, 118km route in a stretched figure eight shape starting and finishing in Ede. Starting in Doetinchem, stage 5 is 140km long. Stage 6 delivers the traditional Arnhem to Arnhem stage for 139kms, with its numerous undulating roads where differences can be made. The latest race content, interviews, features, reviews and expert buying guides, direct to your inbox! Cyclingnews is the world's leader in English-language coverage of professional cycling Started in 1995 by University of Newcastle professor Bill Mitchell the site was one of the first to provide breaking news and results over the internet in English The site was purchased by Knapp Communications in 1999 and owner Gerard Knapp built it into the definitive voice of pro cycling major publishing house Future PLC has owned the site and expanded it to include top features The site continues to be the most comprehensive and authoritative English voice in professional cycling towns and cities across the Netherlands stirred back to life early Saturday morning as preparations for King’s Day festivities got underway and Princess Alexia will celebrate the King’s birthday later today visitors began filling the town center early to secure a good view of the royal family's visit houses are decorated with specially designed flags made for the occasion The festivities are set to begin around midday The royal family will arrive at the square Koperen Kees where rows of people have been standing behind fences for hours to catch a glimpse The KNMI had issued a yellow warning for fog in Gelderland but by mid-morning the mist had mostly cleared with early sunshine and little wind—perfect for a day spent outdoors the NS reported that the first visitors had started boarding trains to various King’s Day activities across the country around 9:30 a.m The NS is operating a special timetable today running more and longer trains on busy routes leading to major events The night and early morning hours passed without major incidents no NS trains are running directly to Doetinchem today Travelers can transfer to Arriva services instead In Amsterdam, the streets were also waking up early. According to Het Parool, street markets the smell of freshly made caramelized popcorn was wafting through Apollolaan where children and adults had begun setting up their stalls Who eats popcorn this early?" Skip said to Het Parool Despite early morning temperatures in the low single digits vendors braved the chill to claim their spots Mathieu Hastman (52) and his son Tom Hastman (16) from Aalsmeer had already made their third sale by 7:35 a.m. explaining they prefer arriving early rather than reserving spaces with chalk as some vendors do "That bodes well," he added cheerfully as he painted flags on faces and continued selling set up a stand offering handmade bandana necklaces "We are normally not allowed to drink bubble tea from our parents because it’s so sweet," Lara said to Het Parool A week of heavy rain across the country, particularly in the east where some areas recorded more than 30 millimeters of rainfall, gave way to stable spring weather just in time for King’s Day, weeronline reports. As the morning progressed the sun continued breaking through from the northeast comfortable conditions expected to last throughout the day Afternoon highs are forecast to reach 15 degrees along the coast and up to 19 degrees near the Belgian border Health authorities are urging festivalgoers to apply sunscreen noting that the UV index is expected to reach 5 While the atmosphere across much of the country was festive and optimistic authorities in Amsterdam were monitoring the aftermath of an overnight incident a stabbing on the Prinsengracht around 3:20 a.m A group of about fifteen young men fled the scene toward Elandsgracht Police deployed a helicopter to aid in the search and have called on witnesses with video footage to come forward King's Night festivities continued relatively peacefully A traditional party took place at Het Sluisje along Nieuwendammerdijk in Amsterdam-Noord while the Nieuwmarkt area remained relatively quiet despite full terraces and spontaneous balcony parties Meanwhile, anticipation was running high in Doetinchem. Nardie Gosselink from Sinderen secured a prime spot along the royal route. Gosselink, who has often been told she resembles Queen Máxima, hopes to meet the queen today and present her with an orange peony, De Gelderlander reports. She and her friend Ingrid Vonk received help finding what Johan Vlemmix called "the best viewing spot." Among the growing crowd was Oscar Meijer from Amersfoort has been offering tubes of licorice to the royal family since 1995 "I heard from her hatmaker that Beatrix loved licorice That’s how it started," Meijer told De Gelderlander the atmosphere in Doetinchem remained calm and pleasant with local police patrolling and inspecting the route with blankets laid out displaying everything from household items to royal memorabilia some tension lingered in Doetinchem following news that protesters had registered plans to demonstrate during the royal visit the municipality has not disclosed who filed the protest request Authorities have designated a specific protest area to contain any demonstrations Doetinchem has announced the route that King Willem-Alexander and his family will take in the municipality on King's Day which will be celebrated this year on April 26 They will arrive via bus from the Burgermeester van Nispenstraat before walking to the Raadhuisstraat via the Plantsoenstraat The royal family will then go over the IJsselkade to the Walmolen The royal family has not celebrated a Dutch monarch's birthday in Doetinchem before It is the first concrete set of plans regarding the king's 58th birthday as little is known about the program being prepared for the him and his family and social organizations can submit their ideas to the event organizers A selection of 100 ideas will be made from the options submitted The municipality will announce the chosen activities in the coming weeks but the national holiday is typically not organized on a Sunday chose to celebrate Queen's Day on her mother's birthdate This April's holiday will also be the first time the event is organized in the province of Gelderland in 16 years when the royal family visited Apeldoorn in 2009 to celebrate Queen Beatrix That Tuesday afternoon was marred by tragedy when Karst T drove a black Suzuki Swift through the crowd to try to ram the royal family's bus as it proceeded towards Het Loo Palace to honor what would have also been the 100th birthday of Queen Juliana was the eighth individual to die from their injuries Residents and visitors in the city of Apeldoorn can be seen placing flowers at a memorial to the victims every year on April 30 Today is King’s Day in the Netherlands, a day full of celebrations to mark the monarch’s birthday. King Willem-Alexander and his family will celebrate in Doetinchem, which has a whole lineup of events planned for the royals, locals, and other visitors. But there are many other parties and flea markets across the country. The weather will be sunny and warm Doetinchem has a day filled with fun cultural activities lined up for King Willem-Alexander and his family starting with a welcoming song by the band Normaal The route ends at the festival site at the historic Walmolen, where duo Suzan & Freek will perform their song De Overkant, a tribute to the Achterhoek, accompanied by the Gelders Orkest Phion. A map and more details are available here The King’s Day festivities in Doetinchem will start an hour later than planned, to give space for Pope Francis’s funeral Prime Minister Dick Schoof and Minister Caspar Veldkamp of Foreign Affairs will rerpesent the Netherlands at the funeral people in the Netherlands will celebrate King Willem-Alexander’s birthday with flea markets and all kinds of parties In Amsterdam, for example, there’s the Kingsland festival in the Olympic Stadium, the Burst festival in the Meerpark, and Cartel Kingsday in WestWeelde, Parool reported The nightclub Radio Radio is holding a block party in the Westerpark from 1:00 p.m. and an afterparty starts there at 8:00 p.m In Rotterdam, there’s the KBF in the Kralingse Bos, Oranjebitter in the Roel Langepark, and the Oranje festival on the Noordplein. There will also be a fireworks show on the Schiehaven from 10:00 p.m., AD reported King’s Day is celebrated on April 26 instead of on the King’s actual birthday That is because Willem-Alexander’s birthday fell on a Sunday this year and the tradition is to preserve the Sunday rest Doetinchem has announced the program and route for the national King’s Day celebrations this year King Willem-Alexander and his family will celebrate his birthday with performances by Suzan & Freek and the band Normaal Mayor Mark Boumans presented the plans after riding into the hall on an electric moped The city wants to show its traditions and how they fit into the new era That’s why the royal bus will be accompanied by authentic and electric mopeds The Achterhoek band Normaal, known for their hit Oerend Hard, will receive the Royal family. “It may be in conflict with my political views, but I am pro-monarchy,” frontman Bennie Jolink told Omroep Gelderland “The kingdoms in Europe are the most progressive countries That can hardly be a coincidence now.” He wouldn’t say what song the band would be performing the Royals will be presented with presentations of arts The municipality received hundreds of initiatives with plans for these That is also what King’s Day is about for me: connection and society.” The route ends at the festival site at the historic Walmolen where duo Suzan & Freek will perform their song De Overkant “We can’t wait to play at a place that feels like coming home to us,” the duo said King’s Day is being celebrated on Saturday instead of on the King’s actual birthday on the 27th and it was decided to move the celebration so that the Sunday rest can still be observed Doetinchem expects 25,000 to 30,000 visitors on the day and has earmarked 3 million euros for the party The Public Prosecution Service (OM) has recommended a four-year jail sentence against Margot H A 41-year-old from Doetinchem for killing the baby Sem Vijverberg in January 2006 Her criminal case will be heard at the court in Arnhem on Wednesday The lifeless body of the baby was found near the end of January 2006 in a frozen lake in Doetinchem An investigation proved that the boy was killed with violence and left behind He was given the name Sem by one of the children who had found the baby The last name Vijverberg is a nod to the stadium of the local professional football club De Graafschap H. was arrested in September 2022 after a tip that came as a result of extensive media attention for the cold case said that she does not remember anything of the pregnancy or the birth in the past I keep realizing that I am not getting the answer,” the suspect said while crying The OM believes it is proven that the biological mother purposely took the baby’s life in January 2006 and placed the body in the lake There is no evidence for a murder charge as the OM cannot prove that H The Public Prosecution Service assumes that the suspect was not aware of her pregnancy until she gave birth and was suddenly confronted with a child was arrested in September 2022 and was in pre-trial detention for two weeks it became clear that she had already been sent a letter on August 5 from the police requesting that she contact them in connection with the investigation It was also announced that she had canceled ten appointments with the police between August 2021 and the end of February 2022 for reasons that were not always valid She indicated that she was in quarantine after testing positive for the coronavirus even though she taught a class at school the same day She did not answer any of the critical questions asked by the court about this The letter was found in a toiletry bag in the basement during a house search “I did not hide it there intentionally,” she said King Willem-Alexander and his family will celebrate his birthday in Doetinchem next year, the government information service announced on Friday Because his birthday falls on a Sunday next year King’s Day 2025 will be held a day earlier than usual King’s Day is usually celebrated on Willem-Alexander’s birthday the festivities will take place on Saturday “The flag can be raised!” the Gelderland municipality wrote on X saying it was looking forward to welcoming the King and his family De vlag kan uit!🇳🇱Op zaterdag 26 april 2025 mogen wij Koning Willem-Alexander en zijn gezin, samen met andere leden van de Koninklijke Familie welkom heten bij de viering van Koningsdag 2025. 👑 #koningsdag2025 #Doetinchem pic.twitter.com/EjgcfUc8Tf This is the second time in his reign that Willem-Alexander cannot celebrate his birthday on the actual day due to it falling on a Sunday The Divinity School is pleased to announce that Raissa von Doetinchem de Rande will be joining the faculty as an Assistant Professor of Religious Ethics Professor de Rande comes to us from Rhodes College in Memphis where she is an Assistant Professor of Religious Studies with an appointment in the program in Jewish She received her PhD from Princeton University (Department of Religion) in 2021; in addition she holds a BA from the University of Oxford (2012) and an MAR from Yale Divinity School (2014).   Professor de Rande’s research interests lie at the intersection of the study of Islam and religious ethics The author of numerous articles and book reviews The Politics of Islamic Ethics: Hierarchy and Human Nature in the Philosophical Tradition is forthcoming with Cambridge University Press in the New Cambridge Studies in Religion and Critical Thought series The book focuses on the Qurʾanic concept of a divinely created human nature and its reception in early Islamic philosophy de Rande will begin offering courses in Spring of 2025: “Islamic Ethics I: Foundations” will set the Islamic tradition in conversation with issues ranging from individual flourishing and the organization of society to conceptions of law and prophecy “Islamic Supersessionism(s)” will explore Islamic engagements with the question of the relation of Islam to previous revelations Metrics details Predicting healthy physiological aging is of major interest within public health research longitudinal studies into predictors of healthy physiological aging that include numerous exposures from different domains (i.e Our aim is to identify the most important exposome-related predictors of healthy physiological aging over the life course and across generations Data were used from 2815 participants from four generations (generation 1960s/1950s/1940s/1930s aged respectively 20–29/30–39/40–49/50–59 years old at baseline wave 1) of the Doetinchem Cohort Study who were measured every 5 years for 30 years a physiological aging index consisting of blood pressure The average exposure and trend of exposure over time of demographic Random forest was used to identify important predictors The most important predictors of healthy physiological aging were overweight-related (BMI waist/hip ratio) and cholesterol-related (using cholesterol lowering medication Diet and educational level also ranked in the top of important exposures No substantial differences were observed in the predictors of healthy physiological aging across generations The final prediction model’s performance was modest with an R2 of 17% our findings suggest that longitudinal cardiometabolic exposures (i.e overweight- and cholesterol-related measures) are most important in predicting healthy physiological aging This finding was similar across generations More work is needed to confirm our findings in other study populations is a major area of interest within public health research it is possible that predictors of healthy aging differ across generations This is a population-based prospective study that studies the impact of (changes in) lifestyle factors and biological risk factors on various aspects of health and well-being of Dutch adults living in Doetinchem It currently consists of six repeated measures with 5-year intervals over a 30-year period self-completed questionnaires were collected and a physical examination was performed on a random sample of 12,404 (response rate: 62%) participants aged 20–59 years from the town of Doetinchem a random sample of 7768 was re-invited to be examined in 1993–1997 (wave 2 2,815 participants with complete data on the outcome in this study (i.e Measurements of the exposures were based on data from wave 1 through 5 Because age is a major predictor of healthy physiological aging and in the current study we were interested in other predictors than age the age-adjusted HAI was used as an outcome measure the average HAI score for each age was subtracted from the HAI score of an individual of that particular age The resulting score provides an indication as to how an individual fares when compared to his/her age peers a score of 0 indicates an average HAI score for the participant’s age a negative score indicates a relatively poor HAI score for the participant’s age and a positive score indicates a relatively good HAI score for the participant’s age Demographic exposures consisted of the following: sex (men; women) educational level based on highest level of education attained (primary education or less; lower vocational education or lower secondary education; intermediate vocational education or higher secondary education; higher vocational education or university) nationality (born in the Netherlands; born elsewhere) marital status (single; married; widowed; divorced) household composition (living with partner; living with partner and children; single-parent household; single household; other household) Biological exposures consisted of anthropometric exposures measured by trained staff according to standardized protocols (body mass index (BMI) exposures measured in blood (total and HDL cholesterol) and self-reported use of cholesterol lowering medication body weight and height were measured by trained staff with participants wearing light indoor clothing without shoes The model with the optimal settings was used to make predictions on the test dataset and the corresponding RMSE and MAE were determined and compared with a model without any exposures that simply predicts the training dataset mean (i.e using the optimal parameter settings and fitting a RF on the entire dataset the variable importance ranking was determined the most important exposures that predict the HAI are ranked based on the percentage increase in the mean square error (MSE) when a particular exposure is permuted randomly from the RF model with all exposures a post-hoc cross-validation procedure was conducted in which the relation between a x number of top-ranked exposures and the prediction performance was evaluated the RMSE was estimated for each choice of x The optimal value for x was chosen based on the flattening of the resulting curve the top-ranked predictors were listed for the total study population and for each generation separately We additionally calculated the average ranking of the top-ranked predictors of the four generations together PDPs plot the value of the average predicted outcome on the y-axis against each value of the exposure on the x-axis while keeping all other exposures constant at their original values The mean score on the crude HAI scale (from 0–10 higher score indicates better health) was 7.2 (SD = 1.8) in the total study population at wave 6 The age-adjusted HAI score ranged between -6.6 and 4.9 RF was used to examine which longitudinal exposures best predicted the HAI at wave 6 in the total study population After tuning the RF parameters in the training dataset the optimal RF model was fitted on the test dataset 1.27) were modestly improved compared to the null model Variable importance ranking of the 30 most important exposures in predicting the Healthy Aging Index. The x-axis displays the percentage increase in the mean square error (MSE) that occurs when a particular exposure is permuted randomly in the random forest. AUE, Area-Under-the-Exposure; TOE, Trend-Of-the-Exposure Exposure selection through cross-validation showing the prediction performance (root mean square error RMSE) (y-axis) of the model using a particular number of top-ranked exposures (x-axis) The dotted gray line represents the optimum number of exposures to select (x = 10) Out of the 10 top-ranked predictors of the HAI which are all anthropometric measures of overweight and obesity 4 cholesterol-related measures are represented in the top 10 The final two predictors are average Dutch Healthy Diet index over time and educational level which belong to the domains of lifestyle and demographic exposures respectively Partial dependence plots (PDPs) of the relation between the 10 top-ranked predictors and the Healthy Aging Index A positive score indicates a better health All analyzes were repeated for the four different generations separately. For each generation, the parameters of the RF model were tuned, the variable importance ranking was determined, and the number of most important exposures was selected through cross-validation. The quality metrics of the different models are shown in Table S 3 the prediction performance of the models of the different generations was quite modest The performance was slightly better for the older generations for generation 1960s the RMSE was 1.39 in the null model compared to 1.38 in the final model while for generation 1930s these numbers were 1.88 and 1.55 respectively Table 3 shows the top-ranked predictors of the HAI at wave 6 for the total study population and the four generations separately and also includes the average ranking list of the top-ranked predictors of all generations together Among the total study population and all generations the biological exposures were overrepresented in the top-ranked predictors and waist/hip ratio over time were important predictors of the HAI for all generations the average BMI or waist circumference was the single most important predictor while this was percentage of the time using cholesterol lowering medication for generation 1930s other important predictors besides anthropometric measures were generally measures related to cholesterol a smoking-related measure was found among the top-ranked predictors No notable differences in the relation between predictors and the HAI across generations was observed in comparison with the PDPs of the total study population Using exposures from multiple domains that were repeatedly measured over 30 years we created a prediction model for healthy physiological aging with random forest based on data from a 30-year long cohort study 8 out of 10 of the most important predictors of healthy physiological aging were measures from the biological domain and related to overweight (BMI waist/hip ratio) and cholesterol (use of cholesterol lowering medication the current study indicates that these measures are also the most important predictors of healthy physiological aging which are both aspects of the Healthy Aging Index This limits the possibility to assess the relative contribution of the individual lifestyle exposures in predicting healthy physiological aging The current study indicates that a high BMI is an important predictor of poorer healthy physiological aging across all generations Since no other studies were found that examined differences in predictors of healthy physiological aging across generations more research is required to confirm our findings The performance of the prediction model was better in the older than in the younger generations (e.g reduction in RMSE in the final prediction model was 18% among generation 1930s and 1% among generation 1960s This might indicate that it is more difficult to predict healthy physiological aging earlier in life or that the included exposures were less important predictors of healthy physiological aging earlier in life the (relative) importance of these exposures may become apparent especially at older ages the majority of predictors reflected the average exposure over time (AUE) instead of the average trend in the exposure over time (TOE) This suggests that the average exposure level over the life course is more important in predicting healthy physiological aging than the actual change in exposure Strengths of the current study are its longitudinal population-based design in which participants were repeatedly measured over the course of 30 years and the inclusion of a wide range of exposures from different domains of the exposome we studied both the average level of exposure and changes (trend) in exposure over the life course participants who were included in the current study were found to be younger and healthier than participants of the Doetinchem Cohort Study who dropped out This may limit the generalizability of our findings to less healthy populations Another limitation is that not all exposures were measured at every measurement wave diet was only measured from wave 2 through 4 If dietary information would have been available for the wave prior to the measurement of the outcome (i.e this might have further increased the predictive ability of this exposure it is important to note that most exposures were measured at every wave we were able to take into account changes of exposures over the life course by examining both the average exposure over time and the average trend in the exposure over time exposures from the environmental domain were lacking from the top-ranked exposures predicting health uncertainty remains with respect to the predictive value of air pollution and green space measures in the general Dutch population This is because the current study was conducted among adults from one particular town in the Netherlands thereby leading to limited variation in these measures nationwide studies may be needed to determine the importance of physical environment measures prediction models should ideally be validated in other study populations to assess their potential to be generalized longitudinal overweight-related exposures were the strongest predictors of healthy physiological aging Other important predictors of healthy physiological aging were related to cholesterol levels our findings suggest that exposures from the biological domain are most important in predicting healthy physiological aging due to the modest performance of the prediction model more work is needed to better predict healthy physiological aging and to confirm our findings in other study populations the resulting insights from these efforts will be valuable in the early identification of people who are likely to age unhealthily The datasets generated and analyzed during the current study are not publicly available due to ethical restrictions related to participant consent but are available from the corresponding author on reasonable request World Health Organization. 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Available from: https://earthexplorer.usgs.gov/ A measurement of social support in epidemiological research: the social experiences checklist tested in a general population in The Netherlands A short scale for measuring social support in the elderly: the SSL12-I The development of a Rasch-type loneliness scale Classification and regression by randomForest Hyperparameters and tuning strategies for random forest Wiley Interdiscip Rev Data Min Knowl Discov Building predictive models in R using the caret package Association of body mass index and waist circumference with successful aging Obesity and ageing: Two sides of the same coin The metabolic syndrome–a new worldwide definition ACCF/AHA 2011 expert consensus document on hypertension in the elderly: a report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus documents developed in collaboration with the American Academy of Neurology American Society for Preventive Cardiology Obesity-induced 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Relation to Changes in a Healthy Aging Index: The Health Download references This study was funded by the Strategic Program project “COMPLEXA” of the Dutch National Institute for Public Health and the Environment (RIVM) The funding bodies had no role in the study design; collection and interpretation of data; writing of the manuscript; or the decision to submit the manuscript for publication National Institute for Public Health and the Environment Julius Center for Health Sciences and Primary Care BL and GCH wrote the first draft of the manuscript All authors commented on previous versions of the manuscript All authors read and approved the final manuscript The Doetinchem Cohort Study was performed in accordance with the Declaration of Helsinki and approval was obtained from the external Medical Ethics Committee of The Netherlands Organization for Applied Scientific Research and the University of Utrecht Informed consent was obtained from all individual participants included in the study The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations unless otherwise stated in a credit line to the data Download citation DOI: https://doi.org/10.1186/s12877-023-03789-2 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Metrics details Cognitive decline is part of the normal aging process some people experience a more rapid decline than others due to environmental and genetic factors Numerous single nucleotide polymorphisms (SNPs) have been linked to cognitive function To understand whether cognitive function and cognitive decline are driven by the same mechanisms we investigated whether 433 SNPs previously linked to cognitive function and 2 SNPs previously linked to cognitive decline are associated with both general cognitive functioning at baseline and general cognitive decline up to 20-years follow-up in the Doetinchem Cohort Study (DCS) The DCS is a longitudinal population-based study that enrolled men and women aged 20–59 years between 1987–1991 General cognitive function was assessed using four cognition tests measuring memory age and examination round) were calculated for each cognition test at each round and subsequently combined into one general cognitive function measure using principal component analyses None of the 435 previously identified variants were associated with baseline general cognitive function in the DCS a coding apolipoprotein E (APOE) SNP and one of the variants previously associated with cognitive decline was associated with general cognitive decline in our study as well (p-value = 1 × 10−5 These findings suggest that decline of general cognitive function is influenced by other mechanisms than those that are involved in the regulation of general cognitive function were associated with general cognitive functioning at baseline and general cognitive decline in the Doetinchem Cohort Study (DCS) over an extended period of time (up to 20-years follow-up) and with up to five repeated cognition measurements in older adults (n = 2559) All participants gave written informed consent in each round The study was approved by the Medical Ethics Committee of the Netherlands Organization of Applied Scientific Research and the Medical Ethics Committee of the University of Utrecht according to the guidelines of the Helsinki Declaration Education level was measured as the highest level reached during follow-up and categorized into low (intermediate secondary education or less) intermediate (intermediate vocational and higher secondary education) and high (higher vocational education or university) Participants who were physically inactive or moderately inactive were defined as being physically inactive was used to perform the quality control for both participants and genetic variants Participants were excluded if (Supplementary Fig. 1): (1) there was a sex mismatch (n = 45) (2) samples were duplicates (n = 18) or monozygotic twins (n = 1) (one individual per pair) (3) heterozygosity rate was high (false discovery rate (FDR) < 1%) (n = 37) (4) the sample call rate was <95% (n = 20) and (5) participants were widely diverged (i.e being genetically distant based on visual inspection of a genomic principal component (gPC) plot) regarding their genetic background based on the first two gPCs that were constructed using a kinship matrix the more distant participants compared to the group as a whole were excluded as a single iterative step new gPCs were generated in the remaining sample population and additional participants were removed For 4110 participants both genotype and cognition data were available (Supplementary Fig. 1) Before constructing the general cognitive function measure participants without measurements on all four cognition tests were made missing for that particular round Participants were excluded when: the previous step resulted in missing values for the cognition tests at T0 (n = 45) had cognition measurements at only one time point (n = 768) or had a history of stroke (diagnosed or self-reported (n = 213)) at any measurement 2559 participants were left to study the associations between SNPs and general cognitive function and decline we added rs429358 (chromosome (chr):base pair (bp) 19:45411941) and rs7412 (chr:bp 19:45412079) to our SNP-dataset we selected the 434 ‘independent’ SNPs and the two aforementioned exonic APOE SNPs for our study resulting in a total of 436 SNPs Genetic variants with an imputation quality (R2) below 0.4 or a minor allele frequency (MAF) below 0.01 were not considered for analysis in the present study Since one of the 434 ‘independent’ SNPs had a MAF < 0.01 (rs541507329 the final SNP selection consisted of 435 SNPs based on 433 ‘independent’ SNPs and 2 APOE SNPs We corrected for multiple testing based on the Bonferroni adjustment (i.e a p-value < 1 × 10−4 was considered statistically significant we performed a sensitivity analysis in which we studied the effect of education level in the cross-sectional association between SNPs and general cognitive function with the linear regression model (for baseline cognitive function) as described above to which we added education level as a covariate as long as each participant has at least two observations A linear mixed model was fitted for each SNP and in each model we adjusted for sex and population stratification using the first two gPCs we included time (0–20 years with 5-year intervals and the interaction terms SNP*time and age at baseline*time For this model we used a correlated random intercept and slope since participants with higher cognitive function at baseline (intercept) may have a steeper decline (slope) was considered statistically significant since we are now interested in an interaction term instead of a main effect 0.1/435 = 2 × 10−4) for the interaction term SNP*time a p-value < 2 × 10−4 was considered statistically significant ε2ε4 genotypes were included in the ε4 carriers-group To study the longitudinal association between the three APOE groups (independent variable with ε3 homozygotes as reference group) and decline in general cognitive function (T0-T20) (dependent variable) we used the same model as used to study the longitudinal association between the 435 SNPs and general cognitive decline (see section above) A p-value of 0.1 was considered statistically significant since we were interested in the interaction term APOE haplotype group*time The proportion of explained variance (R²) was calculated using a linear regression model per time point (T0-T20) A separate linear regression model was used to examine the cross-sectional association between the polygenic profile score and general cognitive function at baseline To study the longitudinal association between the polygenic profile score and general cognitive decline we used a linear mixed model adjusting for sex and the interaction terms polygenic profile score*time and age at baseline*time A p-value of 0.1 was considered statistically significant since we were interested in the interaction term polygenic profile score*time This figure shows the trajectories (with 95% confidence intervals) of general cognitive function up to 20-years follow-up (n = 2559) The general cognitive function measure is based on sex age and examination round-adjusted standardized residuals The red dots represent mean general cognitive function at each time point After adjustment for multiple testing, none of the 435 SNPs were significantly associated with general cognitive function at baseline (Supplementary Table 1) The SNP with the lowest p-value (p-value = 2 × 10−4) was rs2782653 located at chr:bp 1:43950265 The alternative allele G was inversely associated with general cognitive function at baseline (Beta = −0.16) compared to the reference allele C None of the other SNPs were significantly associated with a decline in general cognitive function This figure shows the adjusted trajectories of general cognitive function for three APOE groups (i.e ɛ3 homozygotes and ɛ4 carriers) up to 20-years follow-up (n = 2559) At T0, 0.9% of the variance of general cognitive function is explained by the polygenic profile score (Table 3) less variance of general cognitive function is explained by the polygenic profile score a higher percentage (2.9%) of the variance of general cognitive function is explained by the polygenic profile score compared to the other time points we found a statistically significant cross-sectional association between the polygenic profile score and general cognitive function (Beta = 0.72 The longitudinal association between the polygenic profile score and general cognitive decline was not statistically significant (Beta = 0.001 we investigated whether 433 SNPs previously linked to cognitive function and 2 SNPs previously linked to cognitive decline were associated with both general cognitive functioning at baseline and general cognitive decline in the DCS was associated with long-term general cognitive decline but not with general cognitive function at baseline None of the other previously identified SNPs for cognitive function or decline were significantly associated with general cognitive function at baseline In both the DCS study as well as in the study of Davies and Lam et al. since age has such a strong impact on the level of cognitive function it could still have affected the obtained results differentially the heterogeneous phenotype could also have influenced our results regarding baseline cognitive function General cognitive function is a heterogenous outcome in two respects (1) participants can score differently on the individual cognitive functioning tests while they can have the same score on the overall measure one participant can have a low memory test score while another participant can have a low executive functioning test score while they score differently on the underlying tests the average total score may not reflect similar underlying functioning of the participants different tests are used to measure cognitive function in different cohort studies the same neuropsychological test battery was used through all rounds for all participants In the meta-analyses of Davies and Lam et al. data of multiple cohorts were used in which cognitive function was tested using different test batteries phenotypic heterogeneity may be larger in the Davies and Lam study represents different aspects of general cognitive function compared to our phenotype Although there is evidence to support ethnicity dependency of the APOE genotype on brain function this is not likely to be an explanation for the observed differences as both the study of Davies and Lam et al and our study only included individuals from European descent we cannot exclude the possibility that we had limited power to detect the cross-sectional associations found in the Davies and Lam study as we do find an association with the polygenic profile score and general cognitive function at baseline Our study sample was considerably smaller compared to the number of participants included in the Davies and Lam study our phenotype was probably more homogeneous than the phenotype of Davies and Lam et al. but this may not have outweighed the smaller number of observations is significantly associated to general cognitive decline but not to general cognitive function at baseline Baseline general cognitive function could be influenced by other mechanisms than those involved in the regulation of general cognitive decline Lifestyle interventions to prevent cognitive impairment Neural mechanisms of ageing and cognitive decline The 9 year cognitive decline before dementia of the Alzheimer type: a prospective population-based study The association between change in cognitive function and longevity in Dutch elderly Decline in cognitive functioning is associated with a higher mortality risk Summary of the evidence on modifiable risk factors for cognitive decline and dementia: a population-based perspective Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline Cardiovascular risk factors and cognitive decline in middle-aged adults and care: 2020 report of the Lancet Commission APOE genotype and cognitive decline in a middle-aged cohort Effects of APOE on cognitive aging in community-dwelling older adults Apolipoprotein E4 and sex affect neurobehavioral performance in primary school children Cognitive reserve in ageing and Alzheimer’s disease Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing A genome-wide scan for common variants affecting the rate of age-related cognitive decline Genetic architecture of age-related cognitive decline in African Americans Cohort profile update: the doetinchem cohort study 1987–2017: lifestyle Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study Rey’s verbal learning test: normative data for 1855 healthy participants aged 24–81 years and the influence of age The Letter Digit Substitution Test: normative data for 1,858 healthy participants aged 24-81 from the Maastricht Aging Study (MAAS): influence of age The Concept Shifting Test: adult normative data The Stroop color-word test: influence of age and education; and normative data for a large sample across the adult age range Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study Illumina. Infinium Global Screening Array-24 Kit. 2017. http://www.glimdna.org/assets/2017-infinium-global-screening-array-illumina-data-sheet.pdf The GenABEL Project for statistical genomics PLINK: a tool set for whole-genome association and population-based linkage analyses A reference panel of 64,976 haplotypes for genotype imputation Next-generation genotype imputation service and methods Fast and accurate genotype imputation in genome-wide association studies through pre-phasing GWAS meta-analysis reveals novel loci and genetic correlates for general cognitive function: a report from the COGENT consortium ggplot2: Elegant graphics for data analysis RVTESTS: an efficient and comprehensive tool for rare variant association analysis using sequence data Education does not affect cognitive decline in aging: a bayesian assessment of the association between education and change in cognitive performance Educational attainment and cognitive decline in old age Bates D, Mächler M, Bolker B, Walker S. Fitting linear mixed-effects models using lme4. arXiv. 2014. https://doi.org/10.18637/jss.v067.i01 Exceptionally low likelihood of Alzheimer’s dementia in APOE2 homozygotes from a 5,000-person neuropathological study Estimation of effect size distribution from genome-wide association studies and implications for future discoveries Insights into the ageing mind: a view from cognitive neuroscience PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations PhenoScanner: a database of human genotype-phenotype associations LDlink: a web-based application for exploring population-specific haplotype structure and linking correlated alleles of possible functional variants Polygenic predictors of age-related decline in cognitive ability APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline and the clinical expression of Alzheimer’s disease APOE ε2 is associated with milder clinical and pathological A lzheimer disease and cognitive change over the years prior to death Molecular signatures in post-mortem brain tissue of younger individuals at high risk for Alzheimer’s disease as based on APOE genotype Download references We thank the participants of the Doetinchem Cohort Study We would like to thank the field workers of the Municipal Health Services in Doetinchem (C Heusinkveld) for their contribution to the data collection of this study Imholz for isolating and measuring the DNA samples for the GWA SNP determinations Picavet who coordinates the fieldwork since 2007 Blokstra for data management (all from the National Institute for Public Health and the Environment) Kuijpers for his contribution regarding the polygenic profile score analyses This work was supported by the Ministry of Health the National Institute for Public Health and the Environment (grant number S132002) and by Biobanking and Biomolecular Resources Research Infrastructure-NL (grant number CP2011-27) These authors contributed equally: Martijn E MLR drafted the manuscript with major contributions from NCO-M and JLAP performed the quality control and imputation of the GSA-data of the Doetinchem Cohort Study and AW designed the (longitudinal) cognitive psychometric analyses and AW performed/assisted with the data analysis All authors commented on and approved the manuscript Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41398-022-02258-5 A fatal accident occurred on the A18 highway early Saturday morning The incident took place at approximately 2:10 a.m Authorities have not yet released the identities of the victims A police spokesperson stated that investigators worked through the night to determine the cause of the accident The A18 has been closed between the Doetinchem-Oost and Varsseveld exits Drivers heading toward Enschede are advised to detour via Zelhem on the N315 The investigation into the circumstances of the crash remains ongoing Metrics details Risk factors often develop at young age and are maintained over time but it is not fully understood how risk factors develop over time preceding type 2 diabetes We examined how levels and trajectories of metabolic risk factors and biochemical markers prior to diagnosis differ between persons with and without type 2 diabetes over 15–20 years A total of 355 incident type 2 diabetes cases (285 self-reported 70 with random glucose ⩾11.1 mmol l−1) and 2130 controls were identified in a prospective cohort between 1987–2012 Risk factors were measured at 5-year intervals Trajectories preceding case ascertainment were analysed using generalised estimating equations Among participants with a 21-year follow-up period those with type 2 diabetes had higher levels of metabolic risk factors and biochemical markers 15–20 years before case ascertainment Subsequent trajectories were more unfavourable in participants with type 2 diabetes for body mass index (BMI) and to a lesser extent for waist circumference uric acid and estimated glomerular filtration rate compared with participants without type 2 diabetes whereas the increase among persons without type 2 diabetes was 0–2% (P<0.01) The observed differences in trajectories of metabolic risk factors and biochemical markers were largely attenuated after inclusion of BMI in the models Participants with diabetes had more unfavourable levels of metabolic risk factors and biochemical markers already 15–20 years before diagnosis and worse subsequent trajectories than others for maintenance of a healthy weight from young adulthood onwards for diabetes prevention we examined whether trajectories of metabolic risk factors and biochemical markers among initially healthy men and women differed for those who developed T2D and those who did not over a period of up to 15–20 years This led to a population of 2913 men and 3304 women Pregnant women were excluded for the wave in which they were pregnant All participants gave written informed consent in each wave and the study was approved by the Medical Ethics Committee of the University Medical Center Utrecht smoking status and use of anti-hypertensive and cholesterol-lowering medications were obtained by questionnaire All self-reported incident diabetes cases that were not checked (N=109) were considered to have type 2 70 participants were ascertained as having incident T2D by a measurement of random glucose of ⩾11.1 mmol/l in the physical examination for our study This gives a total of 355 participants with incident T2D sex and wave matching to limit the possibility that differences in risk factors due to differences in age and length of follow-up would obscure the differences in risk factors between participants with and without T2D 4 or 5 could be followed back in time for 6 total cholesterol and HDL cholesterol were followed back in time for a maximum of 21 years Other risk factors were followed back in time for a maximum of 15 years since those factors were not measured in the first examination wave Trajectories preceding case ascertainment were constructed by estimating the marginal means based on the parameter estimates at four or five points in time using linear generalised estimating equation models with an autoregressive correlation structure separately for each risk factor and marker (dependent variable) T2D status was included as an independent variable in the model to obtain trajectories separately for participants with and without T2D The model also included the following independent variables: linear and time as a categorical variable (that is which was approximately the mean age at wave 5 and examination wave was centred at wave 5 to fit trajectories for a hypothetical population of 60 year olds in 2008–2012 (T0) Trajectories of diastolic and systolic blood pressure were also adjusted for anti-hypertensive medications HDL cholesterol and triglycerides for cholesterol-lowering medications GGT and CRP and reported geometric means since these biochemical markers did not have a normal distribution For participants with a self-reported diagnosis the date of diagnosis was somewhere between the first wave in which they reported that they had T2D (case ascertainment) and the previous wave Treatment after diagnosis (that took place in between two successive waves of our study) may have changed the trajectories of participants with a self-reported diagnosis and would be reflected in the trajectory over the last 5 years before case ascertainment the trajectory over the last 5 years was not taken into account when testing differences between those with and without T2D in the total trajectories of metabolic risk factors and biochemical markers The time from 15/20 years prior to case ascertainment up to 5 years prior to case ascertainment was used to statistically test differences This was done using an interaction term for the interaction between the independent variables T2D status and time (dummy relating T−15/−20 to T−5) assuming a linear pattern over that period Differences in trajectories of risk factors and biochemical markers between participants with and without T2D during the last 5 years prior to case ascertainment were also tested using an interaction term between T2D status and time (dummy relating T−5 to T0) A P<0.10 was considered statistically significant for interactions The analyses were also stratified by method of case ascertainment (that is self-report and random glucose ⩾11.1 mmol l−1) to further investigate the potential effects of medical treatment after the diagnosis of T2D among the self-reported cases during the 5 years preceding case ascertainment We statistically tested these differences in trajectories by method of case ascertainment using interaction terms between time and method of case ascertainment To investigate whether differences in trajectories between participants with and without T2D could be explained by BMI trajectories were additionally adjusted for BMI and centred at 25 kg m−2 in sensitivity analyses To investigate potential misclassification of controls with high random glucose levels we conducted sensitivity analyses in which we excluded controls with random glucose between 7.0–11.1 mmol l−1 All analyses were performed using SAS 9.3 software (Cary Uric acid (l) and estimated glomerular filtration rate (m) of those with (solid lines) and without (dashed lines) incident type 2 diabetes Geometric means are shown for triglycerides gamma glutamyltransferase and C-reactive protein BMI increased among men and women with T2D with 1.5 kg m−2 (5%) (95% CI: 0.9–2.2) and 2.2 kg m−2 (8%) (95% CI: 1.3–3.1) among those without T2D BMI remained stable over time (P>0.05) Trajectories of diastolic and systolic blood pressure GGT and CRP were also more unfavourable in participants with T2D than in those without T2D although the difference was not statistically significant for triglycerides GGT increased borderline significantly with 0.12 log mg l−1 (13%) (95% CI: −0.004 to 0.25) among men with T2D and non-significantly with 0.05 log mg l−1 (5%) (95% CI: −0.02 to 0.13) among men without T2D between T−15 and T−5 During the last 5 years before case ascertainment levels of metabolic risk factors and biochemical markers remained stable or decreased except for glucose in both sexes and CRP in men total cholesterol (c) and random glucose (d) of those with (solid lines) and without (dashed lines) incident type 2 diabetes stratified by diagnosis based on glucose ⩾11.1 mmol l−1 and self-reported diabetes Note: time before diagnosis ranged from −17.5 to 2.5 among the self-reported cases since participants were diagnosed somewhere between case ascertainment (year 0) and the previous wave Adjustment for BMI strongly attenuated differences in trajectories between participants with and without incident T2D for all metabolic risk factors and biochemical markers except for random glucose (Supplementary Figure 2) exclusion of controls with random glucose levels between 7.0–11.1 mmol l−1 resulted in the same findings as our primary results Men and women with incident T2D had more unfavourable levels of metabolic risk factors and biochemical markers than those without T2D 15–20 years prior to diagnosis Subsequent trajectories were also more unfavourable in participants with T2D than in those without T2D for BMI glucose and to a lesser extent for diastolic and systolic blood pressure markers of liver fat and chronic inflammation The patterns were similar for men and women Differences in trajectories between participants with and without T2D were much smaller after adjustment for BMI A greater decrease in metabolic risk factors and biochemical markers in those with T2D than in controls during the 5 year prior to ascertainment was observed Since the diagnosis of T2D occurred at an unknown time point during the 5 years preceding case ascertainment medical treatment and lifestyle changes will have often already started before the wave in which a respondent reported a diagnosis of T2D This implies that medical treatment and lifestyle intervention after the diagnosis of T2D had a large favourable impact on levels of almost all metabolic risk factors and biochemical markers This is supported by analyses stratified by method of case ascertainment systolic blood pressure and total cholesterol was only apparent in men with a self-reported diagnosis (diagnosed in the years before case ascertainment) and not in cases ascertained by elevated random glucose levels during the examination for our study independent of whether the subject is overweight gaining weight is important in the development of T2D Contrasting findings might be the result of matching on age leading to a stricter adjustment for age and a smaller difference in selective dropout between those participants with and without T2D This may have led to trajectories of controls that were more favourable in our study than in the Whitehall II study and thereby to larger differences in trajectories between those subjects with and without T2D our findings highlight the need for lifestyle interventions to promote the maintenance of a healthy weight from young adulthood onwards to reduce the burden of T2D Our results further suggest that it may be of interest to investigate whether repeated measurements of risk factors can improve risk prediction of T2D including cases not detected by random glucose levels As our sensitivity analyses showed that exclusion of controls with high random glucose levels had no effect on the results and may only have led to a small underestimation if any of the differences in trajectories between participants with and without incident T2D individuals who participate in cohort studies are generally healthier and better educated than non-responders and participants who were excluded and those who dropped out during follow-up also had slightly less favourable levels of the investigated risk factors at baseline This has most likely led to underestimation of the number of participants with T2D and differences in trajectories between people with and without T2D Our results showed that metabolic risk factors and biochemical markers were more unfavourable in people with T2D than in people without T2D 15–20 years or more before diagnosis of T2D and that BMI random glucose and to a lesser extent diastolic and systolic blood pressure uric acid and kidney function gradually deteriorate further up to diagnosis Unfavourable changes in these metabolic risk factors and biochemical markers occurred at the same time and showed a similar pattern in men and women Differences in trajectories between subjects with and without incident T2D were explained largely by unfavourable changes in BMI among participants with T2D stressing the importance of maintaining a healthy weight These findings underscore the need for primary prevention that starts more 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verification of diabetes in the EPIC-NL study Detecting clinically meaningful biomarkers with repeated measurements: an illustration with electronic health records An incidence density sampling program for nested case-control analyses Association between serum uric acid and development of type 2 diabetes The effect of menopause on serum uric acid levels in non-obese healthy women Reduction of serum uric acid by hormone replacement therapy in postmenopausal women with hyperuricaemia A Mendelian randomization study of circulating uric acid and type 2 diabetes Hyperuricemia induces endothelial dysfunction Uric acid: A marker of increased cardiovascular risk Early-adulthood cardiovascular disease risk factor profiles among individuals with and without diabetes in the Framingham Heart Study The incidence of type 2 diabetes in the United Kingdom from 1991 to 2010 Centers for Disease Control and Prevention National Diabetes Statistics Report: Estimates of Diabetes and Its Burden in the United States US Department of Health and Human Services: Atlanta incidence and mortality of type 2 diabetes mellitus revisited: a prospective population-based study in The Netherlands (ZODIAC-1) C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization and waist circumference to nonalcoholic fatty liver disease Obesity and heart disease: a statement for healthcare professionals from the Nutrition Committee Excess weight as a risk factor for kidney failure Curr Opin Nephrol Hypertens 2007; 16: 71–76 Download references Welfare and Sport of the Netherlands and the National Institute for Public Health and the Environment (grant number: S/260263/01/LC) and the Biobanking and Biomolecular Resources Research Infrastructure (grant number: CP2011-27) We thank the field workers of the Municipal Health Services in Doetinchem (C te Boekhorst MSc) for their contribution to the data collection of this study The project director is Professor Dr WMM Verschuren Dr HSJ Picavet coordinates the fieldwork since 2007 Logistic management is provided by P Vissink and the data management is provided by A Blokstra The statistical advice of Professor Dr HC Boshuizen is gratefully acknowledged National Institute of Public Health and the Environment University Medical Center Groningen and University of Groningen The authors declare no conflict of interest Supplementary Information accompanies this paper on the Nutrition and Diabetes website Download citation BMC Medical Informatics and Decision Making (2020) Digital media company OneFootball has appointed Nikolaus von Doetinchem as vice president of OTT streaming and media rights which he will officially take up on 19th April von Doetinchem will oversee OneFootball’s live streaming and on-demand content offering to help drive and build the organisation’s media rights business He arrives from international marketing agency Sportfive “The football media landscape continues to rapidly evolve and OneFootball is perfectly positioned to work with rights owners platforms and broadcasters to provide fans around the world with an unrivalled OTT streaming offering,” said von Doetinchem “I look forward to working alongside Lucas [von Cranch] and the OneFootball team in the years ahead.” Sports data and technology company Genius Sports Group (GSG) has announced David Levy Levy will lead the board’s oversight of Genius’ operations and strategy Major League Baseball’s (MLB) in-house media unit has promoted two long-time senior producers with Marc Caiafa named senior vice president of production and Josh Bernstein named vice president of production.  The 2021 Rugby League World Cup (RLWC21) has strengthened its board with three appointments Jonathan Caine will become the Department for Digital Sue Catton will be the UK Sport representative and Emma Young will be the International Rugby League (IRL) representative which runs the domestic top-flight A-League and W-League soccer competitions has appointed Ryan Sandilands as commercial director and Rob Nolan as director of marketing and data Stacey Knox has also joined the marketing team to transform its operational capability Chief marketing and chief communications officer President, National Rugby League (LNR) Head of data and insights (APAC), PTI Digital Vice president of booking and events for Fiserv Forum, Milwaukee Bucks Managing director, NFL UK Notes: Kirkwood will officially step down on 31st March after nearly 14 years in the role. He initially joined the National Football League (NFL) in 2000. The league’s UK business is now being led by Brett Gosper, the former chief executive of World Rugby who was named head of the NFL in Europe and the UK back in December Already a member? Log in here Life-Course Epidemiology and Social Inequalities in Health Volume 10 - 2022 | https://doi.org/10.3389/fpubh.2022.966155 For five health-related lifestyle factors (physical activity and alcohol consumption) we describe both population trends and individual changes over a period of 30 years in the same adult population Dichotomous indicators (healthy/unhealthy) of lifestyle were analyzed for 3,139 participants measured every 5 years in the Doetinchem Cohort Study (1987–2017) Population trends over 30 years in physical inactivity and “unhealthy” alcohol consumption were flat (i.e. stable); overweight and unhealthy sleep prevalence increased; smoking prevalence decreased The proportion of the population being healthy on all five lifestyle factors declined from 17% in the round 1 to 10.8% in round 6 Underlying these trends a dynamic pattern of changes at the individual level was seen: sleep duration and physical activity level changed in almost half of the individuals; Body Mass Index (BMI) and alcohol consumption in one-third; smoking in one-fourth Population trends don't give insight into change at the individual level In order to be able to gauge the potential for change of health-related lifestyle it is important to take changes at the individual level into account For public health policy it is important to monitor health and health determinants in the population This allows discerning worrisome trends in health determinants that require attention such as an increasing prevalence of obesity or evaluating the effects of interventions such as anti-smoking campaigns In addition to these population trends it is relevant to know what the dynamics are that drive these trends Trends over time in a population are the “net sum” of all changes in individuals who make up that population; visualizing the latter shows a much more nuanced picture than tracing the population average To take an extreme example: a flat (unchanging) trend in average BMI could mean that most individuals maintain a stable weight or in contrast that half of the population loses weight while the other half gains weight This might lead to very different conclusions regarding the need (and potential) for policy interventions To bring to light the spectrum of changes at the individual level it is necessary to follow the individuals making up the population over time and summarize these changes in an insightful manner In addition to studying single lifestyle factors, it is relevant to study combinations of lifestyle factors in order to be able to anticipate the increase in morbidity and mortality in the population due to the accumulation of unhealthy habits (17) Papers studying several health-related lifestyle factors simultaneously over time are scarce Using 30 years of longitudinal data from the Doetinchem Cohort Study we aim to analyze both population and individual level changes within the same study population For the population level the time trends refer to circa 30 years and for the individual level the data spans over circa 25 years The leading question is: what are the population trends and individual changes for five health-related lifestyle factors (physical activity and alcohol consumption)—separately and in combination—in the same adult population By using questionnaires and a physical examination data were included from round one (1987–1991) through round six (2013–2017) covering a 30-years period of data collection that allow tracking individual changes over a time span of 25 years Participants were included in the analyses if they took part in the first and sixth rounds and at least three intermediate rounds Flowchart of the participants of the Doetinchem Cohort Study from round 1 till round 6 and alcohol consumption because we had comparable data on indicators of these factors over the complete 30 year-period in the same cohort Each lifestyle factor was dichotomized as “healthy” or “unhealthy” so we could use the same analyses for every indicator variables of interest such as BMI are also often dichotomized (yes/no overweight) in order to define a proportion of the population at increased risk based on well-motivated cut-off values Participants were defined as unhealthy if they slept <7 h or more than 9 h Based on guidelines by the Dutch health Council in 2015 consuming more than one (>1) glass per day was classified as unhealthy The numbers of missings were low and varied per lifestyle factor For the analyses per lifestyle factor those with missings were excluded so the actual numbers slightly differed per analysis smoking were not excluded from the analyses of physical activity We were also interested in differences between groups Sex assigned at birth was used (as registered in the population registers) Four age groups were created based on age at the baseline measurement and labeled as “10-year generations”: those in their 20s- 30s- those who were in their 40s- at baseline were between 65 and 74 years old in the sixth measurement round Educational level was based on questionnaire data on highest attained level until the fourth examination round Low level meant intermediate secondary education or less intermediate level was intermediate vocational and higher secondary education and high level meant higher vocational education and university Population trends were determined by estimating the prevalence of the unhealthy lifestyle factor in each of the consecutive rounds Individual changes were determined by utilizing the classification of the lifestyle factors into healthy (h) or unhealthy (u) Participants had a maximum of six measurements at different time points resulting in 64 (26) possible patterns of healthy (h) and unhealthy (u) (not counting missing values) These were grouped into five different patterns Respondents could remain “stable healthy” or “stable unhealthy” or change in a healthy (“improve”) or unhealthy direction (“worsen”) If there was only one intermediate deviating value the participants were categorized based on the other measurements participants with the pattern hhhuhh or uhuuuu would be categorized as respectively “stable healthy” or “stable unhealthy” on that factor To be classified as “varying” over time participants had to vary between healthy and unhealthy more than once (e.g. uhuhuh): those were the participants that could not be classified into one of the other patterns For each lifestyle variable the distribution of the population over these five patterns was determined and expressed as proportions of the population adhering to these patterns Besides the trends and individual changes of the single lifestyles we present the proportion of participants that were healthy or unhealthy on all of the studied lifestyle factors and for how many of the five lifestyle factors individuals changed during the study Participants that either “improved” or “varied” in a lifestyle factor were classified as having changed that factor resulting in the possibilities to have changed zero to five factors Remaining stable in all five factors was labeled as being “stable healthy” or “stable unhealthy” A total of 3,139 participants were included in the study, 53% of whom were women (Table 1) The average age at baseline was 37.6 years and 63.6 years in the sixth round Most participants had a low educational level (42.2%) followed by intermediate (31.2%) and high educational level (26.5%) Characteristic of the study population (n = 3,139) Population trends over 30 years—six measurement rounds with a duration of 5 years (1987–2017)—for (A) physical activity Stable physical activity was found among 51% of the population (33.7% stable healthy, 18.3% stable unhealthy), and 49% changed (20.4% varied over time, 15.9% improved, 12.7% worsened) (Figure 3A) This was more or less comparable for both sexes Individual changes over 25 years in (A) physical activity and (E) alcohol consumption: those who remain stable (stable healthy or stable unhealthy) and those who change (improve Stable weight was found among 61% of the participants: 30.7% stable healthy and 30.3% stable unhealthy (Figure 3B) Most of those who changed (39%) became overweight (27.5%) some varied over time (9.7%) and a small proportion improved (1.8%) The majority of the population showed stable smoking behavior: 76.4% (68% stable healthy non-smoker, 8.4% stable unhealthy smoker) (Figure 3C) Bigger stable healthy proportions were found among the older generations and among higher educated participants Sleep was found to remain stable in 56.9% of the participants: predominantly stable healthy (53.6%), a few stable unhealthy (3.3%) (Figure 3D) Those that changed their sleep duration (43.1%) were made up of 19.3% varying sleepers Most change (any) was found in women (45.3%) Alcohol consumption did not change in 70.4:50.2% maintained a healthy consumption (stable healthy); 20.2% was stable unhealthy (Figure 3E) Those who changed their alcohol consumption (29.6%) mostly varied over time (12.8%) The most stable healthy were women (65.4%) The proportion of the population being healthy on all five lifestyle factors declined from 17% in the first round to 10.8% in the last round (Figure 4A) The decline was predominantly between round one (17%) and round three (10.9%) and educational levels showed a similar trend Population trends over 30 years of (A) a healthy lifestyle—healthy on all five factors (B) an unhealthy lifestyle—at least four out of five unhealthy and (C) individual changes of lifestyle over 25 years—number of components that changed The proportion of the population unhealthy on at least four of the five factors was circa 4%, which remained more or less similar during the study (Figure 4B) No differences are worth noting between age or educational groups In 25 years, 11% of the population did not change any of the five lifestyle factors; 29.2% changed one, 32.6% changed two, 19.8% changed three, 6.5% changed four, and 0.9% changed five (Figure 4C) The differences between the sexes and educational levels were minor For those in their 50s at baseline this was 14.1 This study described both population trends and individual changes in the same population, emphasizing that the picture visualizing individual changes is very different from the image that emerges when populations trends are shown. In 2015, the WHO declared “Surveillance of population health and wellbeing” the first Essential Public Health Operation (23) As many population-based longitudinal studies monitor lifestyle from an individual perspective the window they offer on such changes deserves full attention and will strengthen the insights into evolution of health and wellbeing in the population Our study illustrates clearly the much greater dynamics of changes in lifestyle at the individual level than can be seen in population trends This shows better the potential for change of health-related lifestyle than appears when only taking national or regional aggregate figures into account the majority (60%) of the participants changed at least two of the five lifestyle factors—physical activity and alcohol consumption—while population trends showed only a small change In general, our findings on population trends are in agreement with current trends in high-income countries: physical activity level remained stable, prevalence of overweight increased, smoking declined, unhealthy sleep increased, and alcohol consumption remained stable (1–5, 24) This may suggest that what we found on the individual patterns may also be similar for most high-income countries Nine prospective cohorts (up to 28 years follow-up) from the United Kingdom found alcohol consumption after 30 to have remained relatively stable For every lifestyle factor, a considerable proportion of our participants showed multiple changes between healthy and unhealthy. Most existing studies pay little or no attention to this varying category (9, 14, 25, 26) but as it seems highly relevant for the possibilities of prevention this category should receive more attention in studies of individual changes over time These differences are also found here: overweight smoking and unhealthy sleep were more common in the lower educated We did not find differences for physical activity but unhealthy alcohol consumption was more common among the higher educated The differences by educational level seem quit consistent over time The findings of this study have at least two mayor implications for areas of public health: in prevention policy and research it is important to realize that population figures do not tell the entire story To illustrate this from our findings: monitoring of individual physical activity shows that a substantial proportion of individuals changed their activity level These frequent individual changes emphasize that preventive initiatives should not only target change but should also include the stimulation and support to maintain an healthy lifestyle the findings on lifestyle (in)stability should be taken into account in research Most studies on the role of lifestyle in the development of disease are based on a one-time measurement of lifestyle of individuals lifestyles are subject to change: for most lifestyle factors at least one-fourth of the individuals did not remain stable during our study The one-time-measured-life-style-studies do not give a good picture of the disease risks linked to them and it is likely that these risks are underestimations of the real disease risks Our findings emphasize that more attention should be paid to lifestyle dynamics in the population future research may also focus more on what determines lifestyle change The main strength of this study is the use of 30 years of longitudinal cohort data which allowed us to study individual changes parallel with population trends It should be noted that our approach was entirely descriptive the probability that an individual's lifestyle behavior would improve or worsen over the life course there are some limitations to be taken into account we chose to use simple dichotomous indicators of the health-related lifestyle factors in order to make the analyses between the indicators comparable and to analyze multiple factors simultaneously This simplification removes details; only the transitions around the cut-off points are described we used cut-off points that are commonly used and considered meaningful in health research better (more objective) measurements are currently available particularly measurement of sleep and physical activity by wearable devices these are not available yet for a large population and certainly not retrospectively over the last 30 years one important lifestyle factor we did not include in our analyses is food consumption We do have (extensive) data on food consumption by means of a food frequency questionnaire in measurement rounds 2–4 but not from 1 to 6 like the other indicators Finally, individuals that participate in (longitudinal) population-based cohorts tend to be healthier than the general population (31) This “healthy cohort effect” might result in findings that are not one-on-one translatable to the general population The “real” picture is expected to be more unhealthy with lower population figures and larger unhealthy patterns Monitoring five health-related lifestyle factors over a period of 25 years in the same population from both a population and an individual perspective shows the degree to which lifestyle at the individual level is more subject to change than can be seen from in population trends This suggests that the potential for change of health-related lifestyle is greater than appears when only taking national or regional aggregate figures into account The studies involving human participants were reviewed and approved by METC of University of Utrecht The patients/participants provided their written informed consent to participate in this study and ES developed the idea for the analyses ES and AB participated in the data analyses and WV participated in the data collection All authors participated in writing the manuscript and approved the final version and fieldworkers of the Municipal Health Service in Doetinchem for their contribution to the data collection for this study The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based 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amount of sleep for a healthy adult: a joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society Google Scholar and future: trends in sleep duration and implications for public health Young adult weight trajectories through midlife by body mass category energy balance and risk of type 2 diabetes Today's adult generations are less healthy than their predecessors: generation shifts in metabolic risk factors: the Doetinchem Cohort Study Effect of socioeconomic status on propensity to change risk behaviors following myocardial infarction: implications for healthy lifestyle medicine Alcohol intake assessment: the sober facts Validation of self-reported sleep against actigraphy Healthy volunteer effect in a cohort study: temporal resolution in the Adventist Health Study Verschuren WMM and Picavet HSJ (2022) Healthy lifestyle over the life course: Population trends and individual changes over 30 years of the Doetinchem Cohort Study Received: 10 June 2022; Accepted: 22 August 2022; Published: 09 September 2022 Copyright © 2022 Schermer, Engelfriet, Blokstra, Verschuren and Picavet. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: H. Susan J. Picavet, c3VzYW4ucGljYXZldEByaXZtLm5s Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish has further underlined its ambitions in the media rights space with the recruitment of Nikolaus von Doetinchem an experienced media rights executive at the Sportfive agency ©2025 SBG Companies Limited or its affiliated companies a Dutch company involved in the production of amphibious excavators said in their latest announcement that their WK 90 was prepared and transported last week to execute work in Doetinchem at the longest cable waterski track of The Netherlands “The maintenance that was carried out to get the track at the right depth and that made the next group of waiting water-skiers very happy,” Waterking said The track is ready to use again and will contribute to the fun of a lot of water sports enthusiasts Amphibious excavators can be used on land as well as water This means it is possible to easily cross swamps The machine starts to float if activities are carried out in water deeper than 1-1.8 meters (depending on the model) Amphibious excavators can be fitted with additional pontoons for extra stability and buoyancy when performing activities in water between 4.0 and 6.0 meters in depth All Waterking excavators can be fitted with additional pontoons featuring spud poles These additional pontoons are attached to the undercarriage and the spud poles can be operated from inside the cabin Daily news and in-depth stories in your inbox The Pioneers of Offshore Engineering GustoMSC part of NOV’s Marine and Construction business is recognized for providing advanced design & engineering consultancy for mobile offshore units and reliable equipment and technical knowledge into realistic & innovative ideas The performance of new and existing jack-ups German premium beauty retailer Douglas is acquiring a majority stake in Niche Beauty an online business focused on premium cosmetics brands from around the world WHO: Niche Beauty was established in 2011 by sisters Laetitia von Hessen and Sarah von Doetinchem together with their father Andreas Bechtolf to give customers in Germany access to a curated assortment of beauty products from around the world They travel the world to unearth the latest insider tips and product trends for Niche Beauty’s 250,000 online shop visitors Their growing community is a testimony to the management team’s talent for identifying and introducing attractive lifestyle brands Douglas is one of the leading retailers in the European beauty industry with about 2,400 stores and fast-growing online shops in 24 European countries the company generated sales of 3.3 billion euros around 20,000 dedicated beauty experts strive to make their customers more beautiful and thus happier Douglas has a portfolio of some 50,000 high-quality products of more than 650 brands in the areas of perfumery and skincare as well as food supplements and accessories With around 40 million Beauty Card holders Douglas has one of the largest customer loyalty programs in Europe WHY: The acquisition will strengthen Douglas’ position in the attractive luxury segment and allow Douglas to leverage its own high-performance platform to selectively support Niche Beauty’s rapid growth “Our mission is to give our customers access to the world’s most exclusive cosmetic products Teaming up with Douglas means we now have the support of one of the strongest and most renowned European beauty partners—this opens up completely new opportunities for us Douglas is the ideal platform for Niche Beauty to ensure that the next phase of our growth is even more successful,” says Laetitia von Hessen Sarah von Doetinchem adds: “We see ourselves as a lifestyle brand Together with a strong organisation like Douglas we can focus on raising awareness for our business thereby making it more accessible to customers throughout Europe in the future.” “We are always on the lookout for promising investments that improve our portfolio and fit our #ForwardBeauty strategy,” Tina Müller referring to the retailer’s brand strategy “Niche Beauty enables Douglas to add a luxury assortment that perfectly complements the top end of our multibrand strategy.” we are offering our customers a complementary product world in line with our platform strategy,” said Vanessa Stützle Executive Vice President of e-commerce and CRM at Douglas “We see ourselves as a lifestyle brand,” von Doetinchem said “Together with a strong organization like Douglas Multi-time FIM Motocross World Champion Jeffrey Herlings was awarded with the prestigious “Hans de Beaufort trophy” on the occasion of the KNMV Gala at the Amphion Theater in Doetinchem The trophy represents the highest honour in Dutch Motorsports and is handed over once a year to a sportsman who has delivered a performance of world class and who has also proved to be a real ambassador for motorsport and KNMV.Hans de Beaufort was a rider in the 2nd World War who has lost his own life while he tried to save the lives of many others.Statement from the board of KNMV the “Koninklijke Nederlandse Motorrijders Vereniging”: “Jeffrey is a triple world champion motocross with one title in the 85cc and two in the MX2 class.In both 2014 and 2015 Jeffrey was gloriously leading the World Championship series but he was struck by bad luck on several occasions and was unable to extend his impressive list of world titles Yet before he was injured he had proved to be the best MX2 rider in the world by far.In order to win the Hans de Beaufort trophy one needs to deliver world class performances which he has done by remaining at top sports level for a number of years but one has to act as an ambassador for motorcycling as well.The second element in particular has convinced the board of the KNMV to grant this award to Jeffrey right now As years went by Jeffrey has developed more and more into a real ambassador for both the KNMV and the sport As time    a professional sportsman permits he is prepared to make contributions to the development of the sport also towards young riders”.FIM Europe President Dr who has handed over the trophy to Jeffrey Herlings stated: “He is a rider with an incredible talent Everything he does on the bike looks so easy what is probably the highest level of riding He has developed over the years to a real ambassador of the sport and has the potential to become one of the most successful Motocross riders in the history of the sport” | Copyright 2025 FIM Europe | Terms of use - Privacy statement | Please enable JavaScript to view this page correctly King Willem-Alexander and Queen Maxima will not attend the funeral of Pope Francis on Saturday The royal couple and their family will celebrate King’s Day in Doetinchem as planned the government information service RVD announced Prime Minister Dick Schoof and Minister Caspar Veldkamp of Foreign Affairs will represent the Nehterlands at the funeral The Pope died on Monday at the age of 88 He will be buried in the Basilica of Santa Maria Maggiore in Rome Schoof called the Pope “an example for many” and “in everything a man among men.” Veldkamp found him “a source of inspiration.” Belgium and Spain decided to send their royal couple to the funeral but the Dutch royals will stay in the Netherlands to celebrate King’s Day as planned The festivities in Doetinchem will start an hour later “We respect the situation that has arisen and are happy with the cooperation of everyone who makes it possible to start the program an hour later,” said mayor Mark Boumans The King’s Day broadcast was scheduled to start at 10:45 a.m. but will now begin at noon due to Francis’s funeral Willem-Alexander and Máxima said on Monday that they were “deeply affected” by the Pope’s death “We remember our personal encounters with him with warmth including during our state visit to the Holy See in 2017 Pope Francis radiated compassion in everything.” on wednesday, 8 september 2010, queen beatrix of the netherlands officially opened the new amphion theatre in doetinchem by mecanoo theatre director henk raben and architect francesco veenstra toured her majesty around the theatre complex which replaces the successful amphion from the 1970s the new theatre features slightly reclined facades with sand-coloured masonry and a playful pattern of square windows this creates surprising compositions imbuing each space with its own character the audience enters the theatre through an ascending forecourt which plays the role of a red carpet warm red shades prevail within the spacious interior of four linked foyers the horseshoe-shaped main auditorium with three balconies and a total of 860 seats maintains an intimate atmosphere owing to the close proximity of the audience to the stage the small 300 seat theatre has is flexibility of due to a flat floor construction and is almost an exact replica of the small theatre hall of the old amphion only the fly tower on the exterior betrays the presence of the auditorium. visitors have a perfect view from every seat onto the imposing 36 x 19 meter stage floor which is suitable for all large-scale theatrical productions the small 300 seat hall can be used as a black box and is almost an exact copy of the popular small theatre hall of the old amphion the u-shaped layout of movable stands ensures direct contact between actors and spectators the venue is transformed into a concert hall or a ballroom performances are changed at a relatively high speed efficient loading and unloading is required mecanoo provided the loading and unloading area with enough space for three 18-meter long trucks centred between the stages of the two theatre halls located on the same floor level this space can also be used to temporarily house stage sets or to exchange sets between the large and small theatre halls the main hall is equipped with fully automatic features in the 29 meter high fly tower the large and small theatre halls have windows so that the technical staff has daylight in their workplace program: theatre with large 860 seat theatre hall lobby and theatre café totalling 9,700 m2 design: 2006-2008 realization: 2008-2010 client: cultural centre theatre amphion sa delft project management and building cost consultant: bbn consultants nieuwegein technical theatre advisor: theateradvies bv rotterdam contractor: aan de stegge bouw & werktuigbouw goor building costs including installations: 23,130,000 euro AXOR presents three bathroom concepts that are not merely places of function but destinations in themselves — sanctuaries of style This website has been translated using an AI program space and secretly many undiscovered highlights Orangerie De Pol is a surprisingly beautiful location in a place where you wouldn't expect it; just outside the center of Doetinchem one of those chic glass greenhouses in the middle of typical Dutch nature 10 points and then we still have to go inside You can dine in that beautiful glass greenhouse Sleek round tables with white linen and an open kitchen Really in the middle of nature and that makes it so much fun but also very nice when it may be freezing but crystal clear and you can see the stars during dinner You're actually always in a different setting Oh, and if you already had a weekend in the Achterhoek planned, Then take a look here for more tips.  and if you want to try something different an alcohol-free package (we normally never do this Highly recommended, Orangerie de Pol King Willem-Alexander turned 58 years old on Sunday but celebrated his birthday a day earlier as the royal family traditionally refrains from public activities on Sundays It is the second time since Willem-Alexander ascended the throne that his birthday has fallen under these circumstances King Willem-Alexander was born on April 27 in Utrecht as the first child of Princess Beatrix and Prince Claus the royal family celebrated Koningsdag in Doetinchem Willem-Alexander did not indicate on Saturday whether he would hold a private celebration on Sunday he called the festivities in Doetinchem "a fantastic day." The schedule for Koningsdag began more than an hour later than usual to accommodate the funeral of Pope Francis King Willem-Alexander paid tribute to the late pope in a video message "The community spirit of Pope Francis is also a hallmark of Koningsdag," he said "This is all the more important in this time of tensions and uncertainties in the world around us and legal certainty are not self-evident." arrived in Doetinchem around noon and were welcomed by Mayor Mark Boumans Joining them were Prince Constantijn and Princess Laurentien and Prince Pieter-Christiaan and Princess Anita The Achterhoekse band Normaal played their biggest hit, Oerend Hard, upon the family's arrival, according to NOS. King Willem-Alexander enthusiastically sang along and afterward climbed onto the stage to shake hands with lead singer Bennie Jolink Prince Constantijn also enjoyed the performance Following several cultural performances and a culinary break featuring regional dishes from the Achterhoek the royal group proceeded to an area labeled "Sportlaan 1 tot 100," where various sports demonstrations took place Both the king and queen participated in a game of table tennis during which King Willem-Alexander scored a point against Queen Máxima with a "keiharde smash," or powerful smash the king faced a setback during the Koningsdag quiz event he and his team were defeated by Queen Máxima’s team who demonstrated particular knowledge of music by the pop duo Suzan & Freek with spectators standing several rows deep behind barriers waving enthusiastically at the royal family According to a spokesperson for the municipality approximately 30,000 people came to Doetinchem for the festivities Many German visitors also joined the celebrations in the city performed the song De Overkant for the royal family Queen Máxima and Princess Amalia sang along clearly knowing the lyrics of the song that celebrates the Achterhoek region King Willem-Alexander thanked the city of Doetinchem for its flexibility in starting the day later than usual He also addressed the many German guests present "We now see what eighty years of peace and freedom have brought us: friendship with each other And let us continue to work on this together As Koningsdag approaches, the festivities throughout the Netherlands promise to offer a wide range of events for everyone, with a special focus on family-friendly celebrations, according to Nouveau. This year the royal family has chosen to stay in the Netherlands where King Willem-Alexander and Queen Máxima will attend the Koningsdag celebrations in Doetinchem The royal visit will be the highlight of a series of festivities spanning the weekend The program in Doetinchem will start with the traditional King’s Breakfast and aubade at 9:30 AM on April 26 Visitors can also look forward to the famous Koningsdag flea market followed by the Ride & Show event at 1:00 PM will keep the energy high throughout the day The festivities will continue with food stalls and more entertainment at seven different venues across the city with performers and demonstrations along the route In other major cities like Amsterdam and Utrecht with events such as the Kingsland Festival the festival will feature more than 150 artists and take over 500,000 square meters of space which runs from 6:00 PM on April 25 to 6:00 PM on April 26 with visitors scouring second-hand goods at hundreds of stalls in the city center This vibrant event is expected to draw massive crowds In addition to these big celebrations, regions like the Veluwe and Bollenstreek offer unique ways to celebrate Koningsdag, AD reports. The Veluwe will host bike tours through stunning forests and heathlands with a stop at the Kröller-Müller Museum and the Museonder offers bike routes through the blooming fields Visitors can rent bikes or e-bikes to fully enjoy the scenery and celebrate the day the Keukenhof in Lisse will be the place to be making it one of the most picturesque spots in the country during Koningsdag Koningsdag will be marked by lively flea markets the celebrations will begin early with a Koningsmarkt at 6:00 AM and include a local youth choir performance Leersum will also offer a festive atmosphere with a breakfast Specific measures are also in place to manage the increased passenger flow. In Amsterdam, stations like Amsterdam Science Park and Amsterdam RAI will be closed on Koningsdag to prevent overcrowding, while travelers attending events at the RAI and the Olympic Stadium are advised to use Amsterdam Zuid station. NS encourages all travelers to plan their journeys in advance using the NS Reisplanner and to allow extra time for travel, especially during peak hours. Additionally, from 7:00 PM on April 25 to 7:00 AM on April 27, an alcohol ban will be enforced on trains and at stations, and luggage lockers at major stations, including Amsterdam Centraal, Utrecht Centraal, Breda, and Eindhoven Centraal, will be unavailable during this period. © 2012-2025, NL Times, All rights reserved. Text description provided by the architects. The municipality of Doetinchem together with the Turkish foundation organized a closed design competition, which was won by Atelier PUUUR in 2007. ‘The architectural design should be a bridge between the religious tradition of the Turkish community and the 'here and now' of Doetinchem in the 21st Century.’ © Milad Pallesh A balance between tradition and modernity is the key to achieve a good symbiosis, from which a sustainable solutions can emerge and become a reflection of the new generation of users. © Milad PalleshExtensively studies has been made to achive the desired balance between Islamic idiom and the Dutch context Attem pting to create a contemporary building that is founded on traditional Islamic architecture principles such as the geometric principles transitions of inside and outer spaces and the principles of the enclosed garden but the more the Islamic symbolism played a part in the design The five division - the five pillars of Islam - can be found in multiple scale layers for example in the columns in the colonnade at the entrances Internal the building is divided into three rings the outer ring forms the supportive and additional program which are separated by a colonnade serving as a traffic zone The vertical articulation of the facade is a guidens to the sky and makes the building appear higher The brickwork facades are in original bond refering to islamic flower patterns Desired elements like identity and recognition can be experienced from the perspective of both cultures You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email Metrics details Obesity and physical inactivity are associated with several diseases such as diabetes few data are available on the specific types of medication associated with obesity and physical inactivity The aim of this study was to determine the independent association of body mass index (BMI) and physical inactivity with use of specific classes of prescription drugs and the interaction between BMI and physical inactivity The Doetinchem Cohort Study is a population-based longitudinal study We analyzed cross-sectional data of 1703 men and 1841 women for whom drug-dispending data were available from the PHARMO database Drugs were coded according to the WHO Anatomical Therapeutic Chemical (ATC) classification system Body weight was measured during the physical examination Physical activity was assessed using an extensive questionnaire Persons were defined as a user of a certain drug class if they filed at least one prescription in the year around (±6 months) the examination Compared with normal weight persons (BMI 18.5–25 kg m−2) obese persons (BMI>30 kg m−2) had a higher use of prescription drugs of several drug classes especially cardiovascular drugs (OR (95% CI): 3.83 (2.61–5.64) in men and 2.80 (2.03–3.86) in women) and diabetes drugs (OR (95% CI): 5.72 (2.32–14.14) in men and 3.92 (1.80–8.54) in women) physical inactivity was also associated with higher use of certain drug classes such as drugs for blood and blood-forming organs (OR (95% CI): 2.11 (1.22–3.65)) and musculoskeletal drugs (OR (95% CI): 2.07 (1.45–2.97)) We found no interaction between BMI and physical inactivity with respect to use of prescription drugs obesity was associated with a higher use of several types of prescription drugs whereas physical inactivity was only associated with a higher use of certain drug classes in women Prices may be subject to local taxes which are calculated during checkout Association of overweight with increased risk of coronary heart disease partly independent of blood pressure and cholesterol levels: a meta-analysis of 21 cohort studies including more than 300 000 persons Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association Joint effects of physical activity and body weight on diabetes and cardiovascular disease US Department of Health and Human Services Centers for Disease Control and Prevention: Atlanta Physical activity and reduced occurrence of non-insulin-dependent diabetes mellitus Health-economic burden of obesity in Europe SHA-Based Health Accounts in 13 OECD Countries: Country Studies: The Netherlands Moderately overweight and obese patients in general practice: a population based survey The impact of obesity on drug prescribing in primary care The relationship between body weight and drug costs: An Italian population-based study Health services use and health care costs of obese and nonobese individuals Pharmaceutical costs in obese individuals: comparison with a randomly selected population sample and long-term changes after conventional and surgical treatment: the SOS intervention study Body mass index and future healthcare costs: a retrospective cohort study Utilization of health care resources by obese Canadians Pattern of drug use in a general population—prevalence and predicting factors: the Tromso study Reported current use of prescription drugs and some of its determinants among 35 to 65-year-old women in mid-Sweden: a population-based study and lifestyle factors among 70–74 year old community dwelling individuals in Western Norway Physical activity and medicine use: evidence from a population-based study Prevalence and determinants of pharmacy shopping behaviour Relative validity and repeatability of a new questionnaire on physical activity Compendium of physical activities: classification of energy costs of human physical activities Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE) Immediate and long term effects of weight reduction in obese people with asthma: randomised controlled study Lifestyle intervention by group care prevents deterioration of Type II diabetes: a 4-year randomized controlled clinical trial Download references the Dutch Medicines Evaluation Board and the Dutch Ministry of Health Centre for Prevention and Health Services Research National Institute of Public Health and the Environment (RIVM) Utrecht Institute for Pharmaceutical Sciences Supplementary Information accompanies the paper on International Journal of Obesity website Download citation Sorry, a shareable link is not currently available for this article. Rotterdam Football Club Feijenoord may have only finished third in the Eredivisie last term but they have a long history of leading the way in Dutch football With Premier League opening day less than two weeks away Saints are set to face their toughest pre-season opponents yet The side based at De Kuip have won the country’s top-flight a whopping  15 times Our red and white counterparts have also had their share of European glory along the way and of course Ronald Koeman have all plied their trade in the red and white strip SFC fans will doubtless remember the last time these two sides clashed The match was also notable as a packed stadium witnessed the return of the then Southampton boss and Feyenoord favourite Ronald Koeman While that fixture was seen  by what was believed to be up to a 50,000 strong crowd (Daily echo) Rotterdam began their journey in altogether more humble surroundings Feyenoord’s official website details a long and proud history in 1908 the club calls the De Vereeniging café its birthplace While the side would quickly grow from its four founder members by the summer of 1912 the powers that be opted for the name Rotterdamsche Voetbal Vereeniging Feijenoord As a new name adorned the organization success followed quickly Within 16 years of their formation Feyenoord had not only gained promotion to the Dutch top-flight Since that day the so-called De Trots van Zuid (The Pride of South, according to Fandom.com ) has continued to dominate the title picture with the last triumph coming as recently as 2017 despite having three handfuls of league silverware the team has only achieved back to back campaign victories just  once those occurring in 1961 and 1962 respectively 1961 also proved to be the start of something special abroad as well After making their debut in that year’s European cup competition Feyenoord were quick to establish themselves reaching the semi-finals the very next year After they’re all conquering exploits on the domestic scene you won’t be surprised to learn that Rotterdam soon tasted European glory as they bested Celtic by two goals to one The 1969/70 trophy may currently be the only success at Europe’s top level but you will also find two UEFA Cup triumphs on the honour roll Southampton are set to be welcomed back to the ground officially known as Stadion Feijenoord, but perhaps better regarded by the name De Kuip, according to the club website Since opening its doors in 1937 the Rotterdam based Stadium has been no stranger to a famous European night or two The ground not only saw the hosts beat Tottenham for the UEFA Cup in 1974 De Kuip is also the regular host of the final for the KNVB Cup competition Ralph Hasenhüttl will be greeted by opposite number, Jaap Stam. The former Netherlands international marks the start of his inaugural campaign with Feyenoord, having only started work last month, according to Feyenoord’s official site Stam will hope his side are shipshape and Bristol fashion against Southampton given that league duties begin the following week Whatever result Sunday’s exhibition provides Feyenoord’s place as one of Holland’s most famous and successful clubs is secure © 2025 Minute Media - All Rights Reserved The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER ","https://fansided.com/",{"alt":"6o","src":"6p","url":"6q"},{"type":"6n","value":"6r"},"link","Minute Media","https://www.minutemedia.com/",{"text":"6u","url":"6v"},{"type":"6t","value":"6w"},"All Rights Reserved Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands who has enjoyed and endured the team all my life I have degrees in sports journalism and public relations If you follow me on twitter you'll also discover my love of While that fixture was seen  by what was believed to be up to a 50,000 strong crowd (Daily echo) Feyenoord’s official website details a long and proud history Since that day the so-called De Trots van Zuid (The Pride of South, according to Fandom.com ) has continued to dominate the title picture with the last triumph coming as recently as 2017 Southampton are set to be welcomed back to the ground officially known as Stadion Feijenoord, but perhaps better regarded by the name De Kuip, according to the club website Ralph Hasenhüttl will be greeted by opposite number, Jaap Stam. The former Netherlands international marks the start of his inaugural campaign with Feyenoord, having only started work last month, according to Feyenoord’s official site Feyenoord vs Southampton: 2019/20 pre-season – Preview A 22-year-old man from Arnhem passed away in the early hours of Friday as a result of a shooting in Pannerden Three men were arrested in Doetinchem after the incident Police received a report about a possible shooting at 2:45 a.m. The victim was not found at the scene of the crime. De Gelderlander reported that a car with a German license plate with bullet holes in the windshield was found at the scene A different police unit found the injured victim in a different car with two other people on the Pannerdenseweg in Zeevenaar Emergency services were unable to get to the victim in time An investigation is also ongoing for shooting incidents at a home in Pannerden and a home in Zeevenaar A shooting was targeted toward a home on the Weiliburglaan The possible connection between these incidents is currently being investigated The Explosive Ordnance Disposal Service (EOD) was called in for the incident at the home in Zeevenaar Possibly because there was a firework bomb involved The three men arrested in Doetinchem were also driving a vehicle that had a German license plate The other is 26 years of age and is from Duiven The woman who was arrested in Braamt sometime later is also from Duiven and is 28 years old “This is an incredibly sad and shocking day for our community,” said Zevenaar's Mayor Lucien van Riswijk “I sympathize with the family and friends of the victim Ajax's Argentine players Nicolas Tagliafico (R) and Lisandro Magallan celebrate the team's championship with the Argentine national flag and Eredivisie Trophy in Doetinchem Ajax's Dusan Tadic (L) and a teammate celebrate with a drum after they won the Dutch champions in Doetinchem L) scores their first goal during the Champions League semi-final second leg match against Tottenham Hotspur