He enlisted in the US Navy and served two tours in Vietnam and was honorably discharged at the rank of BU3 Jim was a Naval Sea Bee and received the Vietnam Service Medal Vietnam Campaign Medal and the National Defense Service Medal Jim was transferred to the Naval Reserve and released from Active Duty Jim was a home builder and carpenter for many years Linda Gordon and Sandy Dantzman; his mother-in-law Denny & Sharon Thorhaug and Shirley Loomis; and many nephews and nieces A Celebration of Life will be at a later date Submit A Story or Press Release: DrydenWire@gmail.com Advertising QuestionsGeneral QuestionsDrydenWire Insider Questions with one of the co-authors warning this could create problems for companies who don't encourage a diversity of ages in leadership positions “The risk of a greater culture divide is present,” Associate Professor at University of Western Australia “Generations have different priorities and views on work-related matters which can create misalignment across the organisation The report, co-authored by Dr Pitosh Heyden of Monash University and Dr Heidi Wechtler of the University of Newcastle looked at the age profiles of chief executive officer succession episodes and found those that are succeeding leaders are growing older in age "Counter to the trend of the general workforce becoming more age-diverse executives appear to have become more age homogenous and increasingly older at appointment," the report found Van Doorn noted the older age of CEOs wasn't uncommon because of the skills and experience needed to be a successful leader – but finds the rise in age and adopting new technology – these are all things that the older generation You’re putting yourself at a potential disadvantage – and the fix isn’t necessarily easy.” “Those that succeed CEOs were generally between 50 and 70 – but now we’re seeing that creep to 60 upwards now." Van Doorn said this could be problematic if it led to limited promotion opportunities and talented team members being stuck in middle management roles He emphasised the importance of investing in employees and developing their leadership capabilities to bring the age of the executive suite down and future-proof it “You’ve got an environment where people are more likely to job-hop why not invest in them and give them the ability to be promoted in-house Managing their talent over time and being transparent with them is more likely going to mean they stay – creating more engaged managers for the future which can also adapt to an ever-changing technological landscape.” perform better in terms of innovation output Investing in your talent from the very beginning is very important – because companies that innovate are going to be more active in things like international mergers and acquisitions Firms that don’t adjust will struggle.” “We don’t have a good enough understanding yet of how we rejuvenate the upper echelons of companies but I think we’re at a critical point because if the age of leaders keeps going up – there’s going to be an even greater divide and potential regression of those that don’t look ahead,” Van Doorn warned HRD Gen Z are fundamentally changing the way businesses operate – and this could be the key to unlocking the next generation of potential leaders Figures from Russell Reynolds, show the percentage of incoming CEOs growing from Q4 in 2024 to Q1 in 2025 “It’s a worry business will have to deal with A lot of firms react to this environmental turmoil by choosing for a very reliable seasoned leader that they think can weather that storm It might be that by taking up such a risk averse approach and they will lag behind,” Van Doorn highlighted to HRD He added that the safe option is not always the right one – especially when considering rapid technological change The reproduction of executive age profiles across CEO succession episodes also found the tenure of S&P500 company CEOs is reducing – from around eight years to around four or five.  “This is a worry change,” Van Doorn warned “because that affects innovation trajectories that could well outlive your time at a company It also affects how our leaders lead – because you could be managing change every half decade Please enable JS and disable any ad blocker SBE alum Lisette van Doorn’s career has been defined by a commitment to leadership and education culminating in the co-development of the Global Leaders Programme in partnership of Maastricht University As CEO of ULI Europe, Lisette van Doorn leads a nonprofit membership organization that brings together members from multiple sectors, all sharing a common interest in real estate and urban development. The ULI is the main global network of leaders in real estate development. The Global Leaders Programme, co-created by the Centers for Real Estate of MIT and Maastricht University supports  mid-career real estate professionals transitioning from managers to leaders It emphasizes a multidisciplinary approach across the real estate value chain This holistic approach is central to ULI’s mission which fosters collaboration between public and private sector professionals from various fields such as architecture you don’t talk much with architects or associated representatives That’s what we aim to change—bringing together different angles Understanding different perspectives enhances success,” she adds Bringing together people with these varied perspectives is also key in the Global Real Estate Leaders Program.  After earning her degree in investment and finance from Maastricht University van Doorn launched her career in investment management at ING in a junior controller role that wasn’t directly aligned with her studies only recognizing later that it offered a broad understanding of the functioning of an investment management business Driven by a passion for real estate for which the interest had arisen during her studies and an internship the opportunity came up to join the investment management business of ING Real Estate (ING REIM) although that required some ‘training on the job’: “I didn’t know anything about real estate at first but I applied my experience in portfolio management to real estate funds and that’s how I got into it,” van Doorn reflects.  Having led the research and strategy team at ING REIM for almost five years a newly formed industry association for institutional investors in non-listed real estate funds Moving from one of the major financial institutions to a non-profit organisation with two employees which practically started from scratch at the time Her subsequent career path included managing ING’s Italian real estate investment management business during the global financial crisis—a formative experience that shaped her leadership style “But I learned that you don’t have to have everything figured out before you take the next step.”  van Doorn emphasizes the importance of being open to new experiences you’ll be in a better place to grow,” she says Rather than obsessing over a perfectly planned career trajectory she encourages professionals to embrace unexpected turns reminding them that what’s more important is doing something they’re excited about—a philosophy that is reflected in her own career.  van Doorn applies these principles to grow the organisation in Europe and provide value to the members while supporting the industry to advance and transform communities The MIT – Maastricht University Global Real Estate Leaders Program is an excellent platform to help accomplish this “We prioritize leadership in inclusive and resilient urban development globally we focus on three key mission priorities: decarbonization and educating the next generation of real estate leaders It’s practical and accessible for all professionals on an individual and corporate level Lisette Groninger van Doorn graduated with a degree in Business Economics from the School of Business and Economics in 1996.This article has been written by journalist Tracy Brown-Hamilton Lisette Van Doorn Chief Executive Europe at Urban Land Institute Patrick van Thiel’s academic journey began in Rotterdam before he found his true calling at Maastricht University in 1989 Drawn by the Problem-Based Learning (PBL) system it wasn’t until he discovered his passion for.. and prepare students for real-world challenges With nearly 30 years of international leadership experience SBE alumnus Samuel Fung brings a powerful combination of global industry insight and personal passion for education to the School’s International Advisory Board Samuel shares what inspired him to join the board Former Global and Virgin Media marketer Cilesta Van Doorn will serve as director of group brand after joining BT in a brand strategy role last year BT Group has appointed Cilesta Van Doorn to the newly created role of director of group brand Assuming the position with immediate effect Van Doorn will lead the development of the BT Group brand strategy drawing on insights about customers and competitors She will report directly to BT Group chief strategy and change officer Tom Meakin with a dotted reporting line to consumer CEO Claire Gillies Van Doorn has been in a contract brand strategy role at BT Group since October 2024 Van Doorn described her new role as helping to shape “the next chapter” for BT and its “iconic brand” this isn’t just a new role – it’s one of those rare opportunities that truly feels meant to be a legendary brand and the chance to build something with real impact as we deliver on our ambition to become the UK’s most trusted connector of people Van Doorn previously served as CMO and a board member at Global for over two years Van Doorn’s remit covered brand marketing ‘Turned on its head’: How EE’s brand transformation is shifting the dial Prior to joining Global, she spent more than three years at Virgin Media, ascending from marketing director to executive director of brand and marketing. She left the company in October 2021 following its merger with O2. Before joining Virgin Media, Van Doorn held a series of senior marketing, brand and corporate communications roles at Tele2 Nederland (T-Mobile Netherlands) and telecoms company Versatel. The creation of the new group brand role comes at a time when BT is looking to push forward. Speaking on the release of the company’s third quarter trading update in January, chief executive Allison Kirkby said BT’s ongoing modernisation “continues at pace”. The firm cited BT Group NPS, which rose four percentage points during the third quarter to 29.6, which the business says reflects “ongoing improvements in customer experience”. On the publication of its half year results in November, BT also claimed customer satisfaction has improved across its three consumer brands – BT, EE and Plusnet – for the first time in nearly three years. EE launched its biggest brand campaign in a decade last year after transitioning from mobile business to a broader service-led model, which its marketing boss says is driving consideration, awareness and purchase intent. EE is in the process of shedding its telecoms label, with a rebrand aimed at making it the UK’s biggest subscription business. Reflecting the obsession with stats in sport, BT Sport dug deep into the data behind the online abuse epidemic to start a nationwide conversation about the scale of unseen hate. After winning the Premier League last Sunday, Liverpool FC’s senior vice-president of digital says the work for marketing is building up to an “even bigger crescendo”. At the end of every week, we look at the key stories, offering our view on what they mean for you and the industry. From Motorway’s CMO and CFO making their relationship a strategic partnership to Coca-Cola highlighting its “localness” in light of geopolitical tensions, it’s been a busy week. Here is my take. The travel industry often finds it easier to “default to visual”, but Expedia says the majority of households it reaches via audio are not reached by any other channel. CEO Brian Chesky says a paid membership scheme like Amazon Prime would be more “compelling” for the travel brand than a points-based programme. some of which ship with Nvidia H200 Tensor Core GPUs Micron is one of 12 companies in the S&P 500 whose gross profit margin have improved sequentially for four straight quarters analysts at Goldman Sachs raised their price target for the S&P 500 for the third time this year large-cap benchmark index to rise to 6,300 over the next 12 months which would be a 10% gain from Friday’s close at 5,751.07 University of Washington rowers won a total of 11 Olympic medals in Paris the highest total in the history of the venerated program Eight UW alumni earned medals in the final day of the Paris regatta Saturday including a gold medal for Jacob Dawson in the men's eight final for Great Britain Dawson was the 2016 UW captain and won bronze four years ago in the Tokyo games Silver in the men's eight went to UW alum Gert-Jan van Doorn who was part of the Dutch team that was defeated by the British squad earning bronze medals for four additional Huskies — Chris Carlson While the Paris Olympics were a record haul for UW Rowing it was not quite a record for the UW as a whole The Huskies won 12 medals in 1936 and again in 1984 The 1936 Olympics included nine gold medals for the UW men's eight with coxswain for the legendary "Boys in the Boat" squad RELATED: What's KUOW's book club reading in August? (Hint: It's "The Boys in the Boat.") UW alum Holly Dunford earned a bronze medal in her Olympic debut with the Great Britain women's eight former UW captain Simon van Dorp won the bronze medal for the Dutch squad RELATED: Seattle Synchro's small but mighty part in this year's Olympic games UW alumni won three additional medals — Tabea Schendekehl won bronze with the German women's quad Phoebe Spoors won bronze withe the New Zealand women's four and Logan Ullrich won silver with New Zealand's men's four it would have ranked 11th for its medal haul Stephen Howie is an Online Editor/Producer at KUOW The Bluffton Charge: One Preacher’s Struggle for Civil Rights won the Mammoth Books Nonfiction Prize nonprofit news organization that produces award-winning journalism By subscribing, you agree to our Terms of Use and Privacy Policy 1);}}@media screen and (prefers-reduced-motion: reduce){.css-wjxay9-SquareButton{transition-property:background-color;transition-duration:0ms;transition-timing-function:cubic-bezier(0 1);}}@media screen and (prefers-reduced-motion: reduce){.css-152q15n-SquareButton{transition-property:background-color;transition-duration:0ms;transition-timing-function:cubic-bezier(0 1);}}.css-x340e0-SquareButton{margin:0;padding:0;display:inline-grid;-webkit-column-gap:8px;column-gap:8px;grid-template-columns:repeat(3 1);}}@media screen and (prefers-reduced-motion: reduce){.css-x340e0-SquareButton{transition-property:background-color;transition-duration:0ms;transition-timing-function:cubic-bezier(0 1);}}.css-v6oqvx{margin:0;font-family:Lato,Helvetica,Arial,sans-serif;font-size:12px;line-height:20px;font-weight:700;letter-spacing:0px;font-style:normal;text-transform:none;font-stretch:normal;padding:0.5px 0px;}.css-v6oqvx::before{content:'';margin-bottom:-0.4973em;display:block;}.css-v6oqvx::after{content:'';margin-top:-0.4463em;display:block;}Listen has been busy over the past week buying stock in an internet domain-name registry company to extend its stature as the company’s largest shareholder Philip van Doorn writes the Deep Dive investing column for MarketWatch Volume 9 - 2015 | https://doi.org/10.3389/fncel.2015.00084 Microglia are important cells in the brain that can acquire different morphological and functional phenotypes dependent on the local situation they encounter Knowledge on the region-specific gene signature of microglia may hold valuable clues for microglial functioning in health and disease Parkinson’s disease (PD) in which microglial phenotypes differ between affected brain regions we here investigated whether regional differences exist in gene expression profiles of microglia that are isolated from healthy rat brain regions relevant for PD We used an optimized isolation protocol based on a rapid isolation of microglia from discrete rat gray matter regions using density gradients and fluorescent-activated cell sorting Application of the present protocol followed by gene expression analysis enabled us to identify subtle differences in region-specific microglial expression profiles and show that the genetic profile of microglia already differs between different brain regions when studied under control conditions these novel findings imply that brain region-specific microglial gene expression profiles exist that may contribute to the region-specific differences in microglia responsivity during disease conditions consistent with the concept of region-specific microglial phenotypes in human tissue The presence and profile of microglial surface markers not only differ between different brain regions in healthy control mice, also a differential responsiveness to various stimuli has been documented (Peng et al., 1998; Vroon et al., 2007; De Haas et al., 2008; Olah et al., 2011; Watson et al., 2012) Prior to studying region-specific differences in microglial expression profiles in a disease model we here study whether gene expression profiles of rat microglia are already region-specific under baseline conditions This is of importance as this expression profile might predict microglial responsivity and hence differential pathological outcomes under challenging conditions we used an optimized protocol to isolate microglia under baseline conditions from small amounts of tissue based on density gradients and fluorescent-activated cell sorting (FACS) which subsequently allowed the analysis of (inflammatory) gene expression profiles in pure microglia derived from brain regions of relevance for PD All experimental procedures were performed and carried out with approval of the animal ethical committee of the VU University Medical Center In each independent set of experiments (n = 3) Harlan) were sacrificed and the brain was rapidly removed and kept in GKN/BSA buffer (see below) on ice Sweden) was diluted 1:10 in sterile 10x PBS to yield 100% isotonic Percoll This isotonic Percoll was diluted in GKN/BSA buffer (GKN 0.8 g/l NaCl 4°C) to yield 75% and 50% isotonic Percoll solutions All procedures were carried out on ice. After removal of the meninges, OB, amygdala (AM), HC, striatum (STR) and SN were rapidly dissected, and placed separately in a plastic Petri dish containing 2 ml of ice-cold GKN/BSA buffer (see Figure 1 for information on anatomical location of dissected regions) Identical regions from 2 rats were pooled per experiment to increase microglial yield Tissue was minced with a razor blade and transferred to a 70 μm pore size strainer (BD Biosciences Belgium) on top of a 50 ml conical tube (Greiner Bio-One) Tissue was then gently dissociated and mashed through the strainer to reach a single cell suspension An additional 30 ml GKN/BSA was added to the tube containing the cell suspension and then the tubes were centrifuged for 10 min at 300x g at 4°C (Hettich FIGURE 1. Anatomical representation of dissected brain regions (adapted from the Rat Brain Atlas; https://gaidi.ca/rat-brain-atlas/) Brain regions that were dissected for microglia isolation are indicated in blue; OB Bregma coordinates indicate the anterior-posterior range of each region that was dissected The supernatant was discarded and the remaining cell pellet was resuspended in 1 ml 50% Percoll and transferred to a new 15 ml polystyrene tube after which an additional 7 ml 50% Percoll was added Then 4 ml of 75% Percoll was gently layered underneath the 50% Percoll layer and subsequently 3 ml GKN/BSA buffer was layered on top of the 50% Percoll layer using a Pasteur pipette The density gradient was centrifuged at 1300x g (Hettich Two distinct layers were apparent after centrifugation The top layer between the GKN/BSA and 50% Percoll gradient consisted mainly of thick The lower layer at the interphase between the 50 and 75% Percoll phases appeared quite faint and contains highly enriched microglia the top layer was carefully removed and then the microglia containing interphase was aspirated and transferred to a 15 ml polystyrene tube Cells were washed twice with 14 ml of GKN/BSA buffer and after adding another 14 ml of GKN/BSA buffer the cells were centrifuged for 7 min at 300x g at 4°C and the buffer was discarded Immediately after Percoll gradient separation and washing steps cells were stained with the following antibodies: Pacific blue-labeled mouse anti CD11b (Serotec MCA275PB; final dilution 1:30) or Alexa647-labeled mouse anti CD45 (Serotec cells per region were incubated for 30 min at 4°C in antibody diluted in PBS and shielded from light cells were incubated for 10 min with Sytox green nucleic acid stain (Molecular Probes S7020; final dilution 1:500,000) to distinguish living from dead cells pelleted at 1200 rpm for 5 min at 4°C and resuspended in 300 μl PBS before they were filtered over a 70 μm size strainer to obtain a single cell suspension ready for FACS analysis and sorting Cell size, granularity, and fluorescence intensity were analyzed per brain region (n = 3) with a MoFlo fluorescent activated cell sorter (Beckman Coulter, Mijdrecht, Netherlands). Approximately 2x104 events were counted and subsequently analyzed using Summit software version 4.3 (DAKO) to determine gates before cells were sorted. Microglia were defined as the percentage of all living, Sytox green negative, cells that showed CD11bpos/CD45low expression (Sedgwick et al., 1991) the FACS sorted microglial cells were transferred into RNAse-free tubes and centrifuged for 5 min at 300x g (Hettich and cells were lysed with 500 μl Trizol reagent (Invitrogen Lysates were stored at -80°C for subsequent RNA isolation no in vivo or ex vivo treatments have been performed with the cells that may change the expression of reference genes Statistical analyses were performed using the SPPS package version 20.0 (Statistical Product and Service Solutions The mean and SD of efficiency corrected and GAPDH normalized mRNA expression in microglia were calculated for each brain region within statistical analysis was performed using a paired sample T-test Bonferroni corrections for multiple testing led to a p-value of 0.005 (alpha/number of tests: 0.05/10) since this may be too stringent for our analysis leading to type 2 errors (false negative) we indicated the results in our graphs as significant with p-value set at 0.05 Flow cytometric analysis based on cell size granularity and viability identified microglia with CD11bhigh/CD45pos expression (A) Microglia appeared homogeneous in cell size and granularity (R1) a DNA-binding dye that is actively taken up by dying cells distinguished the living cells (R2) from dead cells and debris and viability (R1 and R2) resulted in a microglial purity of 92.4 ± 0.87% (mean ± SD) as identified by their characteristic CD11bhigh/CD45pos expression A small fraction of lymphocytes was present to within the viable cells To obtain a 100% pure microglial population Quantification of isolated microglia per brain region Region-specific expression levels of established microglial markers No significant differences were found in AIF1 (A) CD11b (B) and TLR2 (C) mRNA levels between the different brain regions a significantly higher expression was present in the OB compared to other brain regions (CD68: OB vs AM *p < 0.05; IL-1β: OB vs and a significantly higher expression of CD68 (d) in Str compared to AM was found (#p < 0.02) Significantly higher TNF mRNA level (F) was measured in the SN relative to the HC (*p < 0.05) a significantly higher CCR2 mRNA level (G) in SN compared to OB (*p < 0.05) significantly lower P2X7R mRNA level (H) in SN compared to Str and significantly more P2X7R expression (H) in the HC compared to OB (#p < 0.05) indicating that the sorted microglia were not contaminated by astrocytes all values indicated here are based on paired-sample t-test with a significance set at 0.05 they did not survive Bonferroni corrections for multiple testing (p ≤ 0.005) and therefore should be interpreted with care By optimizing protocols to isolate pure microglia from several gray matter regions implicated in PD we could determine brain-region specific microglial gene expression profiles We demonstrate that already under control conditions gray matter-derived microglial cells express markers that are essential not only for regulating brain homeostasis but also do so in a region-specific manner region-specific microglial gene expression was determined in Wistar rats because this rat strain will be used for subsequent PD-related studies we cannot exclude that the results obtained thus far in Wistar rats may differ when other rat strains Also the isolation procedure itself may influence the cell status which is why all brain regions were dissected and the cells isolated and processed immediately and all at the same time The whole procedure was further performed on ice to avoid microglial activation as much as possible and biological triplicates were used to determine variability when microglia isolated from one brain region show a different gene expression profile from microglia isolated from another region such results should then reflect region-specific properties of the cells this could be representative for the clear antigen-presenting function that microglial cells can have and with the notion that microglia in the OB are already in a primed state under normal conditions This suggests that OB-derived microglia may be more prone to priming than microglia derived from other gray matter brain regions which in turn may lead to differential outcomes between different brain regions when confronted with pathological conditions Our present data thus support the notion that expression of CD68 and IL-1β expression are related The enhanced expression observed in the OB relative to other regions could be due to the important role of the OB in odor discrimination in rodents In particular the close connections to the outside world may be of ultimate importance for the microglial cells to be in an easily alerted state to monitor and respond to possible changes in homeostasis A protein typically known to be involved in oxidative cell stress responses is NOS-2 Since we could not detect NOS-2 in microglia derived from various brain regions this supports the notion that the naïve rats we used did not experience cell stress and that experimental handling conditions of our samples did not induce oxidative stress in the cell seither in our current study using naïve rats no differences were present in microglial TLR2 mRNA levels between the regions studied This supports the idea that TLR2 is distributed in an evenly manner throughout the brain under normal conditions and is mainly upregulated by microglia when they encounter specific pathogens does not represent a marker for primed microglia The related high expression of TNFα in the SN (present study) thus supports an enhanced sensitivity of the SN to neurotoxicity P2X7R in the HC has strategic implications for monitoring deviations in ATP levels resulting in cell proliferation and plasticity changes that likely contribute to adaptive behavior seen under disease conditions like PD The fact that these sets of genes were undetectable in our current study whereas genes related to the classical activation state of microglia IL-1β and TNFα were present suggests that the brain region-specific differences in microglia gene expression profile under healthy conditions are more related to the classical activation pathway in these cells This implies that genes expressed by alternatively activated microglia would become more important when homeostasis is derailed but would remain undetectable under naïve conditions The present data demonstrate that a unique basal gene expression signature of microglia exists that differs between different gray matter brain regions of Wistar rats glial cells play critical roles in the homeostatic mechanisms that support neuronal survival Since the basal profile of microglia is more tuned toward a pro-inflammatory profile and in a region-dependent way such region-specific gene expression profiles of microglia likely predict different outcomes under challenging and disease conditions region-specific differences in neuronal susceptibility in conditions like PD be attributable to basal differences in levels of inflammation-related receptors and other factors that are endogenously AvD and PL designed research; KD and JB performed research; IH and HB contributed analytic tools and protocols; KD Tom O’Toole (Department Of Molecular Cell Biology and Immunology VUmc) is thanked for his assistance with FACS sorting We thank the International Parkinson Foundation for support (to PL ionized calcium binding adaptor molecule 1; IL 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NFT Profound cardiac sympathetic denervation occurs in Parkinson disease α-Synuclein alters toll-like receptor expression CrossRef Full Text | Google Scholar Microglial TNFα mediates enhancement of dopaminergic degeneration by brain angiotensin Pathoanatomy of Parkinson’s disease Stages in the development of Parkinson’s disease-related pathology Purinergic signalling: from normal behaviour to pathological brain function Inflammatory response 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stimulated glial cell proliferation Citation: Doorn KJ, Brevé JJP, Drukarch B, Boddeke HW, Huitinga I, Lucassen PJ and van Dam A-M (2015) Brain region-specific gene expression profiles in freshly isolated rat microglia. Front. Cell. Neurosci. 9:84. doi: 10.3389/fncel.2015.00084 Copyright © 2015 Doorn, Brevé, Drukarch, Boddeke, Huitinga, Lucassen and van Dam. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) or licensor are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Anne-Marie van Dam, Neuroscience Campus Amsterdam, Department Anatomy and Neurosciences, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, NetherlandsYW13LnZhbmRhbUB2dW1jLm5s Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish the Tops International Auction will once again open its doors offering an exclusive opportunity to acquire some of the finest sport horses destined for the pinnacle of show jumping.  Set against the vibrant backdrop of the WBFSH Studbooks Jumping Global Champions Trophy [26 - 29 Sep 2024] at the Longines Tops International Arena this highly anticipated event brings together decades of expertise and dedication to quality offering a curated selection of young talent are the future stars of the show jumping world Whether you are looking for the next champion or a hidden gem the Tops International Auction presents a treasure trove of renowned sport horses and untapped talent Not only is this an opportunity to secure an exceptional horse The revenue from the sale of the foal UNO will benefit two impactful charities: De Stalvrienden and the ITOT Foundation supporting their ongoing missions to make a difference Don't miss your chance to invest in the future of show jumping and contribute to these important causes Learn more about the collection Unveiled below: Horses available through the exclusive Tops International Auction 2020 | 165cm | Diamant De Semilly x Van Gogh an Olympic final in Rio de Janeiro and countless placings in the biggest classes around the globe That is a summary of Lintea Tequila’s record as a sporthorse The former mount of Edwina Tops-Alexander is once again pursuing an elite status Patapasco is a son of Lintea Tequila and Diamant de Semilly This 4-year-old stallion is very promising Exactly what you’d want for a top level prospect 2018 | 166cm | Comme Il Faut x Kentucky Ter Doorn In Crosby Ter Doorn Z is the 2024 Champion of 6-year-old horses in Italy at the Piazza di Sienna But also at an international level this stallion went clear 6 out of 8 classes this season one can see he is sired by the Grand Prix winning stallion Comme Il Faut who has now also sired the Olympic champion Checker also come with the last quality at the jump making this stallion a regular in prizegiving ceremonies.  High Five van de Broekkant is a classic gelding by Harley VDL and Ustinov His dam is a sister of Alberto Michan’s successful Gigolo vd Broekkantn who was 2nd in the 4* Grand Prix and won the Nations Cup of Vancouver Another brother of the dam is Giavanna Rinaldi’s Snapchat and the Nations Cup and Grand Prix winner Olaf of Leon Thijssen is a brother of the grand dam He is careful and scopey and will offer great comfort in the big classes of our sport © 2025 World of Showjumping - All rights reserved Powered by Artionet - Generated with IceCube2.Net Purchases made through our links may earn us a small commission — at no extra cost to you Opening with a single declaration from Eke “It is time,” promptly introduce the purpose and energy of Unite As pulsing lead builds behind her stark words before the bass and percussion join in Sander van Doorn quickly takes over from here showcasing his incredible production powers the synths and percussion combine to create a hard-hitting yet inviting atmosphere Throughout Unite van Doorn allows the music to ebb and flow raising and lowering the energy to ensure that listeners have time to catch their breath in between drops Check out the powerful new single, Unite, from Sander van Doorn and Eke now. Don't miss out on the biggest news, editorials & interviews from the dance music industry in our latest magazine. you would probably expect the information technology sector to be at the top Receive emails when new obituariesare published to our website Each of our funeral homes offers a complete range of services in tastefully decorated Professionally trained and licensed staff members stand ready to provide sensitive caring service and strive to exceed the expectations of each and every family.Our communities are wonderfully diverse in religious beliefs Our staff truly appreciates these differences and our training includes heartfelt understanding and respect for the special needs of all whom we serve Hartford | Windsor | Poquonock | Granby | Suffield | South Windsor | Rockville | Vernon | Avon© Carmon Community Funeral Homes | Funeral Home Website Design By Frazer Consultants & TA Your browser may not work with certain site. Upgrade now. This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Please email us at publicaffairs@yu.edu Copyright © 2023 | Yeshiva University News | Editor Login | Privacy Policy In just nine years since John and Butch VanDoorn opened their chassis fabrication business in Muskegon the brothers have built nearly 200 race cars and established themselves as national players in the asphalt Late Model field VanDoorn Late Models have scored victories at nearly a dozen tracks in Michigan and Pennsylvania; plus farther-flung first-place finishes at Tucson Speedway in Arizona; Kern County Raceway Park and Madera Speedway in California; South Sound Speedway in Washington; and Petty International Raceway in New Brunswick October was a particularly good month: On the 8th Cody Dempster nailed down the Super Late Model track championship at Colorado National Speedway; a week later Eddie Van Meter claimed the CRA Super Series Championship VanDoorn’s new Diamond chassis debuted with a third-place finish at Nashville Fairgrounds Speedway in Tennessee No one seems more surprised at the success of VanDoorn Racing Development than John VanDoorn “We’re building chassis number 185,” he noted when we spoke in November “So we’re almost 200 race cars into this thing If you’d asked me in 2013 if we’d ever reach this point ‘not in a million years.’ We never imagined it would take off the way it has.” While asphalt Late Models remain VanDoorn’s signature product—from rollers to race-ready vehicles—they actually account for about 40% of the company’s total business The remaining 60% comprises body repair; building and dyno-testing shock absorbers; a parts department stocked with components from more than 30 top-name performance brands; consulting services including driver development; and fabrication jobs outside of the racing industry (TIG-welding damaged fuel tanks for 18-wheel trucks has become a minor specialty.) “You always want to stay diversified,” VanDoorn explained But chassis building is still the face of our business and everything else is built on it.” Furthermore VanDoorn sees a synergy in the company’s various activities And they are hiring us to come out and work on their cars.” VanDoorn referred to race-car building as his “destiny… and I started welding when I was about five years old “Building things,” and particularly fabrication has interested him for as long as he can remember “I guess it was my calling in life,” he continued and then it turned into serious business as we got competitive when all my friends were into video games and sports It was like the Earth was trying to tell me what my life was going to be.” Around the same time—in the year 2000—VanDoorn graduated from go-karts to dirt-track street stocks and sportsman At 16 he began running Late Models on pavement and went to work for Port City Racecars in Muskegon “I would go there after school to sweep the floors and clean the shop By 2010 I was driving the house car while also building cars and setting them up That’s how I began my career as a race-car manufacturer.” By then John’s younger brother Butch worked at Port City as well Then when he was about 14—about the time my driving career was taking off—he really took an interest in shock building He was 16 when he built his first-ever Penske shocks and I won the very first race I ran with them I was inside the race car looking out; he was outside the race car looking in We have been fortunate to have both perspectives.” Butch and John both “had a really good career going at Port City.” Yet that wasn’t enough John drew a familiar metaphor from popular music: “If you’re a musician in a band and it may even be a successful band at that The Brothers VanDoorn left Port City in November 2013 to launch VanDoorn Racing Development but in just three-and-a-half years we outgrew it,” John said “Then the building we are in now came up for sale so it was set up perfectly for what we do.” Today the main facility covers 9,600 square feet and the company employs nine people full time As much as he values his experience as a driver John rates his 2020 retirement from racing as one of the best decisions of his career “That really expanded our business—it really opened things up for us—because it allowed me to be at the race track helping our customers.” Another key decision was the move to larger quarters “which allowed us to bring in more machinery and equipment when asked what sets VanDoorn Racing Development apart from its competitors and our speed turning out products—how fast we can build new things Such prompt manufacturing and repair is enabled not only by “being set up in the shop with the right tools and equipment,” but also by experience—“knowing what to do”—and by “the work ethic of doing whatever it takes to keep the customer happy we designate people to build that part and ship it out the same day it may take a couple of days to get out there so you have to be flexible enough to make sure that every customer gets to the race track on the weekend.” VanDoorn emphasized “follow-through with every customer and do whatever it takes to make sure they get the part bolted on their car correctly and working in the proper fashion.” Asked how his role in the company differs from his brother’s John told us that he manages “more of what goes on in the shop while my brother handles consulting and sales He’s the one who’s on the phone with customers 24/7.” That said both brothers consult with customers and even crew chief for a few select teams “Because I drove for 25 years,” John added I can offer not only chassis tuning but also driver coaching—all the little things that help a driver gain an edge and do well I’m gone 20–25 weekends out of the year as a crew chief and there are probably half a dozen teams that I help John lamented that “there are so many races out there and we can’t be at them all.” But having a brother as a business partner sure helps “Butch can fly off to an SRL race in California while I go to Indiana or Pennsylvania the same weekend.” and crew chiefs,” confirmed Buddy Shepherd who drives a family-owned Super Late Model in the Spears SRL Southwest Tour Shepherd started racing karts when he was four and graduated to Super Late Models on asphalt as soon as he turned 16 He’d been driving an SLM for about a year when the late Nick Sivesind asked him to sub for his regular driver at Madera “It was my first time in a VanDoorn car,” Shepherd recalled “and I won the race.” Shepherd continued to drive for Sivesind and in early 2018 finished second to Kyle Busch in the 4th Annual Winter Showdown at Kern County Raceway The team purchased a new VanDoorn car in 2020 and Shepherd acquired another after Sivesind’s untimely passing in late 2021 We spoke just a few weeks after he’d won the Southwest Tour race at Irwindale in September 2022 “When I do business with VanDoorn,” added Bob Wheeler pointing us in the right direction and keeping us rolling.” Wheeler grew up in a racing family; his grandfather and uncle are in the Michigan Motorsports Hall of Fame “I traveled to races with them for years,” Wheeler recalled we decided to go out on our own and do our own thing with an Outlaw Late Model I met Butch and Johnny when they were working at Port City Butch helped us with our shocks and setup; he saved us time and money and improved our performance right off the bat So when they started building their own chassis we bought a new car from them—it was chassis number 13 we set a couple of fast times and won a couple of races.” Wheeler later traded number 13 for the improved model VanDoorn released in 2016 he bought two new cars from VanDoorn and was “in the process of building two more” when we spoke in November “They help us keep up with the times,” Wheeler concluded “and with the big teams that travel all over the country.” “We have some really good customers,” John VanDoorn noted Being competitive and providing customer support are the two things that keep you relevant in this industry.” and the winning exploits of VanDoorn drivers But John readily admitted the limitations of the medium “Social media is certainly prevalent in our industry but it isn’t everything like it is in some other industries.” Racing still relies on “a lot of word-of-mouth”—and on satisfied customers who win races The VanDoorns refer to their vendors as “partners” and “you want to align yourself with a company that produces a great part so you have to line up with manufacturers who can get parts out to you right away.” for everything that has contributed to VanDoorn’s success John said that he was “most proud of our employees probably the biggest challenge is finding qualified help Our society and our culture have gone down the wrong road and aren’t grooming people very well for the industrial trades but the ones who are working for us right now are all doing a great job They are all extremely talented go-getters And each one has a strength that they contribute to our product.” He switches metaphors again to muse about the future of the VanDoorn enterprise “At this point the train is really humming along While the Coyote platform is close to peaking in performance opportunities A look at new products from companies that keep pits and garages efficient STAFFAN-MITCHELL ~ CELEBRATING 170 YEARS OF SERVICE ~ 1853-2023 the son of Sam and Martha (Krommenhoek) Doorn Following graduation from Creston High School in 1965 Len entered and completed an apprenticeship program at the GM Fisher Body Plant in Grand Rapids where he then worked as a Journeyman Patternmaker for 32 years and Chrysler stamping plants working to improve metal formability processes and welder.  His Upper Peninsula home reflected all of his many talents.  He was also the neighborhood “go to” guy for anyone who needed help with a project.  He enjoyed fishing and she survives.  Also surviving are one sister and three nephews and one niece.  He was preceded in death by his parents and one brother-in-law Cremation has taken place.  A celebration of his life will take place at a future date.  Arrangements by Staffan-Mitchell Funeral Home contributions in memory of Leonard Doorn can be made to Mayo Clinic for ILD Research.  Send to:  Department of Development Controversial Dutch politician Arnoud van Doorn — who quit Geert Wilders’ far-right party and converted to Islam — was arrested at the weekend for “plotting” to kill the prime minister Police arrested van Doorn for acting “suspiciously” while in the same neighborhood as Mark Rutte in The Hague He was released from custody without charge on Monday Van Doorn told local media he was in the area to give medication to his mother’s cat and stopped for a coffee at a café that just happened to be opposite the gym where Rutte was working out Rutte was this week reportedly given extra security in response to fears of a kidnapping or an attack by an organized crime gang. According to De Telegraaf, officers from the Royal and Diplomatic Security Service (DKDB) have been deployed to shadow Rutte van Doorn converted to Islam shortly after leaving Wilders’ Freedom Party which failed to win a seat in this year’s parliamentary election He has been convicted for sending anti-Semitic tweets, leaking council documents to the press, possessing an illegal firearm and selling drugs to minors. Ahead of this year’s election, van Doorn kicked one of the party’s candidates off the list because she refused to stop selling cakes in the shape of penises restaurants and bars — will be able to resume normal operations at full capacity for the first time in almost two years German demands for more gas are putting the Netherlands in a tricky position bars and cultural venues will be allowed open until 10 p.m after having been shuttered since December 19 Revelations deepen concerns about Beijing’s policy of ‘elite capture’ in Europe Attallah College of Educational Studies Dr. Kristen Doorn, current lecturer in the Attallah College of Educational Studies Integrated Educational Studies Program (IES) program teaches an English and education-focused course called “IES 340: Children’s Literature and Literacy.” Dr from the University of Miami in Language and Literacy in Multicultural & Multilingual Settings She was inspired to teach a course about children’s literature and literacy because of her passion for literature and her belief in the importance of literature in the lives of students and young adults As a former classroom teacher and now a parent fostering students’ literacy skills early on has always been a passion of hers Doorn emphasizes the importance of accessibility A big question addressed in the class is: How do you find texts that students can connect with and reflect who they are as individuals while giving them a window into other worlds children’s literature provides a safe space for children to talk about complex issues in their own lives and the world around them through the medium of a book Fieldwork opportunities in this course include observing read-alouds at the Orange Public Library and reading to students at Chapman’s Centro Comunitario de Educacion a community education center that Attallah College operates in Santa Ana Chapman students can practice read-aloud skills with students of different ages and learn how literature affects different communities they learn about different organizations within their communities that support literacy education Doorn’s favorite children’s books are informational books on space and space travel and her favorite young adult (YA) novel is The Hate U Give by Angie Thomas She also recommends Tara Westover’s Educated a powerful memoir about a young woman and her struggle to understand her identity and seek a better future for herself students will become passionate about reading and look to share that passion with others in their lives as future educators Excerpt from the Attallah College Undergraduate Student Newsletter Teacher Appreciation Week Spotlight: Attallah College Alum Lexi Samuelian Earns National Board Certification - Elementary teacher in the Los Angeles area credits Chapman faculty for shaping her reflective practice Chapman University’s Attallah College Welcomes New Spring 2025 Kappa Delta Pi International Honor Society Initiates Attallah College Celebrates Research and Collaboration at 2025 NASP Annual Conference Empowering Future Mental Health Leaders with Restorative Justice Practices Virtual Reality and AI Could Transform Behavioral Assessments in U.S 2025-2026 Attallah College Faculty Promotions Reflections on an Academic Life - Message from Dr Reflections on the 2019-2020 Academic Year - Messages from Attallah College Leadership April 17, 2025 by | Uncategorized Encouraging students to pursue higher-level science and math courses requires deliberate planning especially for those students historically underrepresented in those fields Schools can’t put more advanced courses on the schedule without teachers who feel confident taking on the material simply offering such classes doesn’t necessarily mean students will enroll in March 25, 2025 by | News Chapman University’s Attallah College of Educational Studies had a strong presence at the 2025 National Association of School Psychologists (NASP) annual conference in Seattle with faculty and students contributing to 14 activities Annmary Abdou co-presented a paper on restorative justice and led a Amenra have newly released an alternate version of their latest album The Belgian post metal outfit had Seth Manchester give a new mix and mastering job to the release for this sonically adjusted take on the album which they’ve dubbed “De Doorn (Version 2)“ “An album is never an endpoint for us Playing these songs live also makes them “alive” We are always interested in seeing or hearing what others might do to one and the same recording Different band members sometimes have different opinions and tastes and we strive for everyone in the band to be able to have a mix and master that truly comes close to what was aspired at first We will therefore be releasing a new version of our latest album ‘De Doorn’ coming January 21st Guitarist Lennart Bossu also shared his thoughts on the matter: “We were familiar with Seth from his work with bands like The Body and were therefore eager to see the direction he would take the songs in Seth really succeeded in bringing our sound as close as possible to what I had envisioned another side to the story that is ‘De Doorn’.” "These bands are way too popular to be in arrears." "Guess you'll have to go Steal This Album if you want to hear it now.." Huis Doorn in the Netherlands struggles to attract visitors due to controversial legacy of last German emperor 16 miles east of the Dutch city of Utrecht lies the mummified corpse of Kaiser Wilhelm II His lead coffin is draped with a flag bearing the black eagle of Prussia According to some historians, at the end of the first world war the last German emperor was only able to flee the British and French gallows to live in exile in the Netherlands because of the help of his distant cousin, the Dutch queen Wilhelmina She had used her blood ties to persuade Wilhelm not to invade the Netherlands during the war Academic research is soon expected to definitively prove what much of the evidence suggests: that the Dutch queen later repaid Wilhelm by letting him cross the border to safety in the centennial anniversary of the end of the war the Dutch royal family is again emerging as the key to saving the kaiser resting place and 45 hectares of grounds at risk of ruin five trains pulling 59 carriages arrived at Zeist station filled with his possessions Today those possessions remain largely untouched On his deathbed lies a small bunch of snowdrops and a note from his mourning son who was serving in Hitler’s Wehrmacht when his father died Wilhelm’s morning gown hangs in his bedroom Read moreThat decision was reversed a year later, but funding was guaranteed for only four years. That was when the Dutch royal family stepped in again. Princess Beatrix, the Dutch queen until her abdication in 2013 visited the museum in 2014 to open an exhibition on the Dutch experience of the first world war Wilhelm’s library at Huis Doorn Photograph: Judith Jockel/The Guardian“It had been a continuous discussion from the 80s and 90s: should the Netherlands support a German museum the director of the foundation that runs the museum “We relied on the idea that this should build support for the museum.” Beatrix returned again this month, to open an exhibition in Kaiser Wilhelm’s house of the works of the German sculptor, Käthe Kollwitz to whom Wilhelm – before the war – had refused to give an honour “We would not be able to properly tell that story without this exhibition,” Sietsma said. “It was very supportive when Princess Beatrix came in 2014 and it is very supportive that she has come again now.” The dining room at Huis Doorn Photograph: Judith Jockel/The GuardianThe challenge now and to explain that it was not a German museum a group of up to 40 German monarchists pay their respect at the mausoleum “I think it is very important to say: we don’t honour Kaiser Wilhelm here,” Sietsma said “And we instruct all our guides to say ‘we don’t honour him and nobody wants to honour him Release date: June 25, 2021 | Relapse Records | Bandcamp | Facebook To set things straight right from the start and being referred to as such within this review and elsewhere is only due to the term’s convenience and overall comprehensibility Amenra is a collective of musicians whose existence stretches beyond the boundaries of music in its standard form and hence can’t be described with any single tag They are an aural and visual phenomenon with a nothing short of a cult-like appearance and fanbase in only the most positive senses of the word Amenra are known for their massive live shows being able to invoke a deafening wall of sound all the while conveying it all through heartfelt emotion It’s a simultaneously suffocating and relieving experience as if you were caught in the middle of an exorcism with no clear beginning or ending but somehow enjoying the inexplicable event unveiling all around you their captured form is more restricted in that setting I should add that this is not a jab at anyone as much as it is myself stating the obvious while their recordings have stayed on a permanent rotation in this household I’ve still pondered at times whether or not it’d be possible to introduce that certain meta-level energy into them that’s so pervasive during their live shows And that is exactly where De Doorn comes into picture The act’s Relapse debut was initially composed for two live events titled Fire Ritual which saw the band performing the songs around wooden structures set on fire in a setting meant to rid its attendees of all their inner evils and the things weighing them down for good feature vocals from Caro Tanghe of Oathbreaker fame alongside Amenra‘s own Colin H van Eeckhout; initially designed solely for these occasions they had such strength in them that the band continued to work on them eventually shaping them into a form where they’d be apt for an album but would still express their original intensity and the idea behind the compositions I’d say that the decision to produce De Doorn out of those songs will be Amenra exists in newfound state of genuineness possibly because of the utilization of their native tongue in their output or due to the album being written with the focus lying elsewhere than on the standard album format with additional aspects like Tanghe’s guest vocals or the narrative-esque approach to the entirety thrown into the mix an incredibly engulfing being that sounds more massive than ever before in the context of studio recordings The act has always embraced dynamics as an integral part of their essence through both songwriting and production the spectrum feels wider and more comprehensive than before Amenra has always taken their sweet time within their music slowly building the atmosphere and placing emphasis on crescendo-esque passages so it isn’t surprising that opening track “Ogentroost” takes over four minutes before fully kicking in The humming low swells turn into near-static before a haunting guitar lead seeps in to direct the textured ambiance and soon you’re fully submerged in the band’s dismal signature mishmash of sludge and post-metal viewed through a doom-paced lens The song also introduces the kind of profound evil vibe that I felt was missing from their previous albums Mass V and VI very early on which has been an unparalleled highlight in the band’s discography for me De Doorn seems to threaten that particular album’s position in my mental charts “Ogentroost” is a leviathan-like opener which also features what I believe is the best single riff/part in all of Amenra‘s career The opener flows straight into the second track which shifts the focus to the aforementioned dynamics it being a shorter song that feels like it’s designed to be a bridge between the longer tracks Solely consisting of spoken word and overwhelming ambient echoes its intensity is of the kind of caliber that just makes you stop in your tracks The third track and first single cut “De Evenmens” features Tanghe in a significant position and is perhaps the most habitual song out of the five that constitute De Doorn That doesn’t lessen its impact at all as it’s a perfect example of a band showcasing their capabilities and how they can be as experimental or conventional as they want to and somehow always excel at it Eeckhout’s clean vocals towards the end are also a sonic sight to behold; you can truly sense how choosing to go with their mother tongue brought a tremendous amount of additional depth to Amenra‘s execution “Het Gloren” is a sullen ode to growth and overcoming and the lyrical content resonates throughout the instrumentation as well The song is an ever-advancing mammoth that seeks character and hooks from very simple wiles before arriving to a halt A spoken narrative slowly gathers clean guitar melodies around it and eventually explodes into a mighty outro passage carried out by Tanghe’s agonizing screams “Het Gloren” is in a pivotal position in the context of the album paving way for the imminent culmination awaiting in the form of “Voor Immer” Said closer returns to similar realms as the first tracks drawing out the blood-soaked but cleansing ouroboros that is De Doorn Earlier on I mentioned the band taking their sweet time to arrive at their destination and “Voor Immer” is another perfect example of that; we’re embraced by over eight minutes of gentle and vibrant storytelling that carries tremendous emotional burden with minimal instrumentation behind it and the crescendo goes on and on until the final pulverizing maneuver kicks in from nowhere A completely fuzzed-out string department topped with a plaintive melody and a marching drum beat round out the ensemble before the song reaches its deserved ending leaving the listener motionless in a languid but satisfied state Amenra present themselves in their most versatile Even though it’d be possible to sum up the reasons why in understandable terms it all still boils down to an insoluble blend of fire can’t be properly explained by myself (or anyone else for that matter) The band’s inventiveness holds no bounds or self-inflicted restrictions and I can easily see the album not only landing on a plethora of top charts this year but also turning out to be a favourite amongst their listeners for many De Doorn is something I couldn’t possibly have prepared or hoped for prior to hearing it and that is an amazing feeling to have towards a band that has more or less been a staple amongst their genre for over twenty years they have absolutely no intentions to give up that position and website in this browser for the next time I comment Everything Is Noise is here to bring you music that you connect with accessible space to discuss this music in a open-minded community of fans and creators The Everything Is Noise-Newsletter is currently in maintenance BY Max HeilmanPublished Jun 23, 2021 Be the first to get our biggest stories delivered to your inbox.