organized by the Dutch League of Physical Culture are open to the world in both civilian and military categories The test comprises four separate days’ consecutive walking over distances up to 35 miles (56 km) each day Two-time world cross-country champion Jacob Kiplimo took 23 seconds off his own course record to win over 15km at the NN Zevenheuvelenloop in Nijmegen on Sunday (17) His winning mark of 40:42 is the fastest time ever recorded in a standalone 15km race though Kiplimo clocked a 40:27 split en route to his 57:31 half marathon performance By the time the Ugandan reached 2km (5:26) he already had a clear lead over the rest of the field That lead continued to grow as the race progressed The world and Olympic medallist went even faster for the next 5km reaching 10km in 27:15 – 34 seconds up on his pace from last year and two minutes ahead of the chase pack Kiplimo maintained his relentless pace through the closing stages The men’s race at the eight most recent editions of the Zevenheuvelenloop have now been won by Ugandan men Mike Foppen of the Netherlands emerged from the chase pack to take second place in 43:19 two seconds ahead of Britain’s Marc Scott Ethiopia’s Mizan Alem made a strong road-racing debut to take the title in 46:51 The 2021 world U20 5000m champion held back slightly during the early stages allowing Diane van Es of the Netherlands to carve out a nine-second lead by 2km But Alem gradually made up ground and caught the Dutch runner at about 3.5km She passed through 5km in 15:54 and 10km in 31:27 before going on to cross the finish line in 46:51 Only Letesenbet Gidey (44:20) and Tirunesh Dibaba (46:29) have ever recorded faster winning times at this race Women1 Mizan Alem (ETH) 46:512 Diane van Es (NED) 47:513 Enyish Mengie (ETH) 49:214 Fionnuala McCormack (IRL) 49:225 Haruka Ogawa (JPN) 49:39 Men1 Jacob Kiplimo (UGA) 40:422 Mike Foppen (NED) 43:193 Marc Scott (GBR) 43:214 Rui Aoki (JPN) 43:235 Matthew Kiplimo (KEN) 43:24 This work, The 82nd Airborne Division commemorates the 80th Anniversary of Waal River Crossing, by PFC Roberto Archila, identified by DVIDS, must comply with the restrictions shown on https://www.dvidshub.net/about/copyright The city of Nijmegen has banned adverts for meat products and fossil fuels in public spaces such as train stations and bus stops City Council Member and Party for the Animals Nijmegen representative we put the Plant Based Treaty on the city’s radar Nijmegen is taking a great step toward a more animal-friendly and healthier future for all its residents.” Read more: Denmark Agrees Deal On Agriculture Emissions Tax The move from Nijmegen is also being honored in culinary form: the Nimma Sandwich is to be introduced by the city using vegan ingredients sourced by local farmers and residents The new sandwich is a unique restaurant and academic collaboration with the Michelin-starred De Nieuwe Winkel working with Radboud University and its teaching hospital Radboudumc to create the recipe.  and consume food has a significant impact on our health “We applaud Nijmegen for showing climate action leadership by endorsing the Plant Based Treaty and we are excited to try their Nimma sandwich which will help promote healthy plant-based food and support local farmers and producers.” We know it can be hard to keep cooking up tasty Browse our selection of vegan recipes below he is passionate about the positive impact a plant-based diet can have on the environment From 2025, Nijmegen (the Netherlands) plans to implement three zero-emission zones: the Binnenstad (city center), Hof van Holland, and Heijendaal. In these areas, mopeds and scooters from 2010 or earlier will be prohibited. This initiative is part of the municipality’s strategy to enhance air quality in Nijmegen This policy is also crucial for businesses operating within these zones They will be required to use emission-free delivery vehicles such as electric or hydrogen-powered vans and trucks While there will be a transition period for some vehicles only electric or hydrogen logistics vehicles will be allowed Business owners can choose to invest in their own electric van or truck or utilize a shared delivery service that uses electric vehicles To uphold these regulations, authorities will deploy the Zero DS electric motorcycle from Zero Motorcycles. This Zero DS (A1 category), provided by Electric Motorbikes Nederland will become a common presence on the streets of Nijmegen Predicted lineups are available for the match a few days in advance while the actual lineup will be available about an hour ahead of the match The current head to head record for the teams are SC Heerenveen 3 win(s) Haven't kept a clean sheet in 17 matches Mickey van der Hart is ranked 2 in saves per match in the competition (3.8) Have scored 8 goals in their last 5 matches NEC Nijmegen have won the previous 2 matches against SC Heerenveen. Thomas Ouwejan has created the most big chances for NEC Nijmegen (11) 27 Apr 2025 12:30:00 GMT?SC Heerenveen won 1–0 over NEC Nijmegen on Sun 27 Apr 2025 12:30:00 GMT.InsightsHave scored 7 goals in their last 5 matches NEC Nijmegen have won the previous 2 matches against SC Heerenveen SC Heerenveen is playing home against NEC Nijmegen at Abe Lenstra Stadion on Sun Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder, characterized by microcephaly, immunodeficiency, and impaired DNA repair. NBS is most prevalent among Slavic populations, including Ukraine. Our study aimed to comprehensively assess the prevalence, diagnosis, clinical data, immunological parameters, and treatment of NBS patients in Ukraine. We conducted a retrospective review that included 84 NBS patients from different regions of Ukraine who were diagnosed in 1999-2023. Data from the Ukrainian Registry of NBS and information from treating physicians, obtained using a developed questionnaire, were utilized for analysis. Improvements in diagnosis, including prenatal screening, newborn screening, monitoring, and expanding treatment options, will lead to better outcomes for NBS patients. Volume 15 - 2024 | https://doi.org/10.3389/fimmu.2024.1428724 This article is part of the Research TopicCommunity Series in Primary Immunodeficiencies Worldwide, volume IIView all 11 articles Introduction: Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder NBS is most prevalent among Slavic populations Our study aimed to comprehensively assess the prevalence Methods: We conducted a retrospective review that included 84 NBS patients from different regions of Ukraine who were diagnosed in 1999-2023 Data from the Ukrainian Registry of NBS and information from treating physicians Most patients originate from western regions of Ukraine (57.8%) there has been an increase in diagnoses from central and southeastern regions The number of diagnosed patients per year averaged 3.4 and increased from 2.7 to 4.8 in recent years The median age of NBS diagnosis was 4.0 years (range 0.1-16) in 1999-2007 and decreased to 2.7 in the past 6 years Delayed physical development was observed in the majority of children up to the age of ten years and 41.3% of them had recurrent infections Severe infections were the cause of death in 12% The second most common clinical manifestation of NBS was malignancies (37.5%) Malignancies have been the most common cause of death in NBS patients (72% of cases) Decreased levels of CD4+ and CD19+ were observed in 89.6% followed by a reduction of CD3+ (81.8%) and CD8+ (62.5%) The level of NK cells was elevated at 62.5% Immunoglobulin replacement therapy was administered to 58.7% of patients Regular immunoglobulin replacement therapy has helped reduce the frequency and severity of severe respiratory tract infections will lead to better outcomes for NBS patients Nijmegen breakage syndrome (NBS) is an autosomal recessive disorder classified among inborn errors of immunity (IEI) leading to high sensitivity to ionizing radiation and an increased risk of malignancy Chromosomal instability syndrome was first highlighted in the article by Hustinx et al. (1), where a patient with microcephaly, growth delay, selective IgA deficiency, and chromosomal rearrangements was reported. The etymology of the disorder’s name is associated with the city of Nijmegen, where the first two cases of NBS were described in 1981 (2) Malignancy is a manifestation of NBS and is sometimes the presenting symptom in heterozygous carriers of the pathogenic variant of the NBN gene (2). NBN gene in NBS encodes the protein Nibrin, which is part of the NBN/Mre11/Rad50 complex and, interacting with ATM kinase, halts the cell cycle with DNA repair. Double-strand DNA breaks may occur during normal replication processes and as a result of the impact of damaging agents on DNA (7) In patients with NBS, inefficient repair of DNA breaks occurs in the absence of Nibrin, disrupting V(D)J recombination processes during lymphocyte differentiation (8). Impaired lymphocyte proliferation and differentiation lead to a decrease in their number, the formation of antigen-recognition domains of immunoglobulins, and the T-cell receptor (9) NBN plays a crucial role in neurogenesis (9, 10). DNA damage affects the development of neurons in various parts of the brain. Microcephaly can be caused by alterations in neural progenitor cells in response to DNA damage. Impaired cell proliferation and differentiation, and the absence of Nibrin in NBS patients result in growth retardation (11) Since telomere shortening triggers cell aging the role of Nibrin in telomere maintenance likely also contributes to growth retardation in NBS patients studies have shown the widespread prevalence of NBS among Slavic populations and identified the role of the Nibrin protein in the clinical manifestations of the disease The wide prevalence of NBS poses important tasks for doctors and scientists in Ukraine: establishing molecular-genetic diagnostics of the syndrome adequate clinical management of patients to prevent oncological and other complications of congenital combined immunodeficiency and increasing attention to NBS among children with microcephaly Previous studies examined the course of NBS in a cohort of 26 patients from 1999-2007 (18). In addition, 14 patients from the Lviv region included in the ESID registry were included in the study by Wolska-Kuśnierz et al. in 2015 (19), and 56 patients from Ukraine were included in the cohort of Eastern Slavic population NBS patients, which studied the prevalence of malignancies (4) there have been no comprehensive investigations conducted in recent years on the prevalence and complications of NBS within the Ukrainian population and treatment of NBS patients with 657del5 variant in NBN gene in Ukraine We conducted a retrospective study that included 84 NBS patients from different regions of Ukraine the diagnosis was suspected based on clinical data and in two patients - based on positive neonatal screening results The diagnosis was confirmed by genetic testing in all patients the diagnosis was confirmed at the Institute of Hereditary Pathology in Lviv Ukraine; in four cases - at the Scientific Medical Genetic Center LeoGENE Ukraine; in three cases - at the Invite laboratory USA; in one case - at the genetic laboratory of the National Specialized Children’s Hospital “OHMATDYT” Kyiv; and in one case - at a clinic in Italy where hematopoietic stem cell transplantation (HSCT) was performed A homozygous c.657_661del5 variant in NBN gene was detected in 83 patients and heterozygous c.657_661del5 and c.995-2A>G variants were found in one patient The research adhered to the guidelines outlined in the 1975 Declaration of Helsinki (revised in 2000) and received approval from the Ethics Committee of I Horbachevsky Ternopil National Medical University (Minutes № 75) All participants and/or their parents provided written informed consent To analyze demographic data and clinical signs, we used data from the Ukrainian Registry of IEI (20) We also surveyed immunologists with experience observing patients with NBS using a detailed questionnaire developed by Professor Larysa Kostyuchenko This questionnaire included questions about various aspects of the disease: clinical features Evaluating previous studies on NBS in Ukraine we divided our analysis into three periods: 1999-2007 This approach allowed us to reconcile data and identify certain patterns in the disease dynamics to prevent new cases of NBS in high-risk families a prenatal diagnostics program has been developed at the Institute of Hereditary Pathology The program has already been successfully implemented in five families of heterozygous carriers of c.657_661del5 variant in the NBN gene Molecular-genetic analysis of the pathogenic variant c.657_661del5 of the NBN gene was conducted in probands with clinical suspicion and phenotypic features of NBS DNA isolation and purification were performed using the phenol extraction method and salting-out method venous blood samples collected in EDTA tubes or dried blood spots (DBS) were used DNA was isolated from chorionic villi or amniotic fluid In vitro DNA sequence amplification was performed using the polymerase chain reaction (PCR) method with the following primer sequences 5’-CAGATAGTCACTCCGTTTACAA-3’ and 5’-TTACCTGTTTGGCATTCAAA-3’ and DreamTaq PCR MM (Thermo Scientific) DNA fragment separation was carried out by DNA electrophoresis in a 10% polyacrylamide gel prepared in Tris-borate buffer Electropherograms were scanned on an ultraviolet transilluminator The obtained signals were compared with length markers the sizes of the obtained fragments were detected In the presence of the pathogenic variant c.657_661del5 of the NBN gene in a homozygous state Sanger Sequencing was performed using the QuantumDye sequencing kit (Quantum Seq) on SeqStudio Capillary electrophoresis (Applied Biosystems) Statistical analysis was performed using STATISTICA 10 Qualitative variables are shown as absolute frequencies and percentages Quantitative variables were tested using the Kolmogorov–Smirnov test or histogram for normal distribution and are expressed as median and interquartile range (IQR) Values of p<0.05 were considered significant The median age of all patients was 11 years 61.9% of patients were alive at the time of data collection Four patients were lost to follow-up for various reasons The median age of live patients was 12 years Twelve living patients are currently over 18 years old (21.4%) The median age of deceased patients was 9 years The distribution of patients according to the regions of Ukraine is shown in Figure 1 Figure 1 Geographical distribution of NBS patients (n) by regions of Ukraine Analysis of diagnosed patients depending on the region of Ukraine was conducted. Overall, the largest proportion of patients (57.8%) is registered in the western regions, but in recent years, there has been a trend of increasing the number of patients in the central and northern regions: from 0% in the period 1999-2007 to 35.7% in the last 6 years (Figure 2) Figure 2 Trends in diagnosing NBS patients (%) depending on the period (years) and region The number of diagnosed patients per year averaged 3.4 and increased from 2.7 to 4.8 in recent years (Table 1) The median age of NBS diagnosis from 1999 to 2023 was 4.0 years (range 0.1-16) It decreased from 4.0 years in 1999-2007 and 5.5 years in 2008-2017 to 2.7 years in 2018-2023 The median age of diagnosis also varied depending on the region: in western regions in central and northern regions – 5.5 years (range 0.1-13 years) and in southern and eastern regions – 6 years (range 0.4-16 years); p=0.0838 between western and other regions Table 1 Dynamics of the number of born and diagnosed NBS patients and median age of diagnosis Prenatal diagnosis were carried out in 5 families of heterozygous carriers of pathogenic variant c.657_661del5 of NBN gene In the family where two children with NBS died from complications of Hodgkin’s lymphoma 4 prenatal diagnostic procedures were conducted a homozygous pathogenic variant in the NBN gene was identified a heterozygous variant and normal NBN genotype were identified In the remaining four families at high risk of NBS prenatal diagnosis was performed only once during the subsequent pregnancy after the birth of a child with NBS A homozygous pathogenic variant of NBN was identified in 3 of the investigated cases and only one healthy child was born in one family Data on the clinical course of NBS were provided for 58 patients (69.0%). Microcephaly was noted in all, 4 (6.9%) children were born prematurely, but in 41 (70.7%) newborns, the birth weight was less than 3000 g, while the body length was less than 50 cm in 25 (43.1%) children. The median birth weight was 2800 g, ranging from 1800 to 3800 g (Table 2) only one patient had a head circumference of 34 cm which corresponds to the lower limit of the norm with a median head circumference deviation of -6.5z at 1 year Table 2 Physical development of NBS patients depending on age Delayed physical development was observed in the majority of children up to the age of 10 (Table 3) Deviations in weight were more frequent and pronounced than in body length/height a positive trend was observed in both weight and height Table 3 Frequency of clinical manifestations in NBS patients (n=58) Dysmorphic facial features, such as characteristic faces, sloping forehead, prominent and/or hooked nose, small chin, upslanting palpebral fissures, and abnormal ears, were observed with varying frequency (Table 3) The predominant skin manifestations included café au lait spots (46.6%) and vitiligo (24.1%) All children experienced infections; however they were sporadic during the observation period did not require intensive medication intervention respiratory tract infections were most common: bronchitis (27.6%) and sinusitis (17.2%) Pneumonia was reported in 22.4% of children and urinary tract infections (UTIs) (8.6%) were frequently reported by physicians Four children had hepatitis (hepatitis B and hepatitis C in two children each) two had sepsis unrelated to immunosuppression in HSCT Information about COVID-19 was available for three patients In children receiving immunoglobulin replacement therapy COVID-19 manifested with high fever and respiratory symptoms but did not require hospitalization this patient developed arthritis of the knee joint Severe infections were the cause of death in three children (12%) The second most common clinical manifestation of NBS was malignancies which occurred in 35 out of 80 patients (43.8%) at the time of examination 24 were boys (68.6%) and 11 were girls (31.4%) lymphomas were most commonly observed (62.9%) other types of malignancies were identified (rhabdomyosarcoma 18 had non-Hodgkin lymphomas (NHL) and 4 had Hodgkin lymphoma diffuse large B-cell lymphoma (DLBCL) was observed in 10 patients other types of B-cell lymphoma – in 3 T-cell lymphoblastic lymphoma (T-LBL) – in 4 and peripheral T-cell lymphoma (PTCL) – in one patient The median age of children at the time of malignancy diagnosis was 9.5 years 22 patients (62.9%) with malignancy have passed away while the rest are in remission or continue treatment Autoimmune and allergic manifestations in NBS patients were less common, observed in 15.5% and 8.6% respectively (Table 4) Allergies included atopic dermatitis (4; 6,9%) Table 4 Immunoglobulins and lymphocyte subpopulations in NBS patients (n=48) Immunological data were provided for 48 (57.1%) NBS patients. Decreased lymphocyte levels were observed in 64.8% of them (Table 4) The most common reductions were in absolute values of CD4+ and CD19+ (89.6%) the level of NK cells was more frequently elevated (62.5%) The most common reduction among immunoglobulins was in IgG concentration (72.9%) Immunoglobulin M was within the normal range in most cases ethical considerations must be taken into account especially when neurological impairments progress as congenital chromosomal fragility and radiosensitivity will remain unchanged even with a successful HSCT the decision to pursue transplantation should be considered individually for each patient taking into account the clinical severity of immune defects and other manifestations Immunoglobulin replacement therapy was administered to 37/63 (58.7%) NBS patients with low IgG levels and/or recurrent and severe infections Patients received regular immunoglobulin at a 400-800 mg/kg dose once every 28 days Regular prophylactic immunoglobulin replacement therapy became available in Ukraine only in 2006 immunoglobulin replacement therapy was episodic The median age of starting immunoglobulin therapy was 3.5 years Prophylactic antibiotic therapy was administered in 13/63 (20.6%) patients with recurrent respiratory symptoms Other treatment options included antiviral and antifungal therapy when necessary it was performed in remission of malignancies considering the complicated infectious history progressive decline in T- and B-lymphocytes the first experience of HSCT in Ukraine in a 3-year-old NBS patient was unsuccessful The patient did not have malignancy but had a severe recurrent infection and progressive T-cell lymphopenia A compatible related donor was not available With the help of the Ukrainian bone marrow donor registry a compatible non-relative donor (9/10 match at the A locus) was found in the International bone marrow donor registry After comprehensive pre-transplant evaluation the patient underwent reduced-intensity conditioning (RIC) according to the EBMT/ESID Guidelines for HSCT for primary immunodeficiency (modified preparative regimen for patients with radiosensitivity) Engraftment was achieved within the expected timeframes: neutrophil on day +11 Molecular genetic study of donor chimerism in peripheral blood by PCR on days +27 and +197 confirmed complete donor chimerism - 100% Starting from the early post-transplant period the patient experienced immune complications: graft-versus-host disease (GVHD) which was resistant to glucocorticoid therapy vedolizumab also did not have a positive effect The patient developed gastrointestinal bleeding and multi-organ failure progressed The child died on day 253 after transplantation The diagnosis of NBS in Ukraine began in 1998-2001 at the Department of Hematology of the Lviv Regional Children’s Specialized Hospital (now Western Ukrainian Specialized Children’s Medical Center) (22, 23). Molecular diagnosis for the first patients was conducted at the Institute of Medical and Human Genetics Charité, Berlin, Germany (3, 7, 24) The molecular-genetic diagnosis of NBS in Ukraine began in 2004 at the Institute of Hereditary Pathology Professor Larisa Kostyuchenko played a significant role in the study, diagnosis, and treatment of NBS patients in Ukraine (18, 23, 25). The first cohort of patients (1999-2007) were described by Dr. Kostyuchenko in 2009 (18) The prevalence of NBS patients with the Slavic variant in the western regions of Ukraine as of 2017 was 3.6 per 1,000,000, reaching up to 24 per 1,000,000 in some areas of this region (4), one of the highest in Europe and the world. The highest prevalence of NBS was reported in Poland and the Czech Republic, where it was 3.1 per 1,000,000 (19, 24) although there is a steady trend towards improved diagnosis in central regions NBS was diagnosed in two children due to positive results of newborn screening for SCID confirmed by genetic analysis Wolska-Kuśnierz et al. (19) 2015 described 149 NBS patients with the Slavic variant of NBN from the European Registry for PID among which the majority were patients from Poland (118) and Ukraine (14) the median age of NBS patients in our cohort is slightly lower than in the mentioned study (11 versus 14.3 years) The percentage of deceased patients in our study is slightly lower (33.3% versus 39%) but the children died at a younger age (median age of deceased 9 years versus 11.1 years) Overall, 6.9% of patients were born prematurely, but 70.7% had low birth weight (less than 3000g), while a body length of less than 50 cm was observed in 43.1% of children. Our results coincide with the data described in previous studies (6, 19). Although there were no premature births in the previous cohort, 42.9% of mothers experienced spontaneous abortions during previous pregnancies (18) Data reflecting the dynamics of physical development in NBS are limited. We have shown that up to the age of 10, most patients lag in weight, and a significant portion (from 28.6% to 50%) in body length/height. Another study also showed significantly lower anthropometric indicators in NBS patients than in the healthy population (11). As in our observations, Varon et al. (6) also note that growth deficiency improves with age The improvement in the physical condition of children with NBS may be associated with better diagnosis as well as improvements in socio-economic status and associated conditions that arise with it Microcephaly was observed in all patients with a median deviation in head circumference of -6.5z at 1 year Autoimmune and allergic manifestations are also characteristic of IEI (31, 32), although they were less common in NBS patients (15.5% and 8.6%, respectively), which aligns with reports from other researchers (19) Changes in humoral immunity were most commonly reflected in decreased levels of IgG (72.9%) and IgA (56.3%), which also corresponds to the data from previous studies (62% and 57%, respectively) (19). The authors noted a correlation between the degree of IgG and IgA deficiency and the severity and/or chronicity of respiratory tract infections (19) Implementing newborn screening for T- and B-cell lymphopenia may also help improve early diagnosis of NBS as well as careful registration and vigilance regarding patients with microcephaly Prenatal diagnosis is important for families with cases of children’s death at an early age from severe or recurrent infections or malignancies and the presence of individuals in the family with microcephaly Frequent miscarriages should also raise suspicion of NBS Considering the high frequency of the 657del5 variant of the NBN gene predictive genetic testing may be considered Early diagnosis will allow for appropriate prevention of infections avoiding radiation exposure for diagnosing infections and other pathologies and selecting the appropriate strategy for treating malignancies A noteworthy aspect of this study is that it is the first comprehensive analysis of the prevalence and immunological characteristics of patients from various regions of Ukraine over 25 years Previous studies mainly focused on data from patients in western regions during the initial 10 years of diagnosis or the prevalence of malignancies was limitedly studied The cohort of Ukrainian patients with Slavic variant in the NBN gene is one of the largest in the world which enhances the generalizability of the findings The analysis was conducted on the growth and weight parameters of children with NBS from birth to 18 years which has been insufficiently addressed in previous publications a limitation of this study is its retrospective data collection which posed challenges in obtaining certain data as well as the possibility of missing data or inaccuracies in the medical records and conducting a thorough assessment of result completeness Transitioning to adult care resulted in worsened patient monitoring Another limitation of this study is that we identified the c.657_661del5 variant of the NBN gene while around 10% of patients with NBS harbor alternative pathogenic variants which could influence the epidemiological results The prevalence of NBS in the Ukrainian population may be higher with improved diagnosis and surveillance analyzing data longitudinally allows for identifying diagnostic trends and determining ways to improve both diagnosis and the management of NBS patients The cohort of diagnosed NBS patients with the 657del5 variant in the NBN gene in Ukraine currently comprises 84 individuals making it one of the largest in Europe and the world Malignancies have been the most common cause of death in NBS patients Regular prophylactic immunoglobulin replacement therapy has helped reduce the frequency and severity of severe respiratory tract infections The raw data supporting the conclusions of this article will be made available by the authors The studies involving humans were approved by I.Horbachevsky Ternopil National Medical University The studies were conducted in accordance with the local legislation and institutional requirements Written informed consent for participation in this study was provided by the participants’ legal guardians/next of kin The author(s) declare that no financial support was received for the research This article is dedicated to the memory of LK who passed away at the end of 2023 and devoted her entire professional life to diagnosing and treating patients with primary immunodeficiencies One of her significant contributions was the study of NBS She first described the clinical and immunological manifestations in a cohort of Ukrainian patients with NBS LK began work on an article where she wanted to gather all accumulated experience regarding the diagnosis and treatment of this syndrome in Ukraine We also want to thank the Institute of Hereditary Pathology scientists We express our gratitude to the oncologists and hematologists of the Western Ukrainian Specialized Children’s Medical Center its former head Romana Polishchuk who first paid attention to children with oncopathology and characteristic appearance thereby drawing attention to the problems of patients with NBS We also want to thank all immunologists and oncologists who manage and treat NBS patients in Ukraine Special thanks to the specialists of the Institute of Medical and Human Genetics Charité (Berlin Germany) and the Department of Medical Genetics The Children’s Memorial Health Institute (Warsaw Poland) for their assistance in diagnosing the first patients and establishing genetic diagnostics in Ukraine Author HM is employed by Scientific Medical Genetic Center LeoGENE The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product 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Start your free trial here. NIJMEGEN, Netherlands — Hundreds of U.S. military personnel joined with service members from 34 different nations to complete the 106th edition of the world’s largest multi-day marching event on Friday. The 560 U.S. entrants were among more than 6,400 service members and 40,000 others who marched approximately 100 miles in and around the Dutch city of Nijmegen during the Vierdaagse, or Four Days Marches. One group of service members raised eyebrows from day one. Seven guardians from the 53rd Space Operations Squadron in Landstuhl, Germany, gave Space Force their first team in an event that originated with about 300 Dutch soldiers looking to build stamina in 1909. The guardians enlisted the help of soldiers from Kaiserslautern and Wiesbaden to reach the 12-member team requirement. “Every day has been ‘Space Force?’ and lots of ‘Wait, that’s real?’ so the team has been fielding questions multiple times a day,” Senior Master Sgt. Robert Baer said Thursday. “It’s always great to get the Space Force out there in front of people, because it’s still so new.” The Americans said camaraderie between the international militaries and the hospitality of the Dutch people were the things that stuck out the most over the four days. “Being with all the partner nations and seeing how they do things while being able to exchange patches and shirts with all of them ... it’s great,” U.S. Army Sgt. 1st Class Edward French, who is stationed in Garmisch-Partenkirchen, Germany, said around the halfway point of Friday’s march. “The city, the participation that you see from all the kids and the high fives, you can’t beat it,” French added. In the town of Gassel, a band set up and residents lined the streets before 8 a.m. to hand out snacks and greet marchers as they passed through. “There’s been a couple of towns where we’re marching next to Dutch soldiers and they’re cheering for the Americans. They really care for us just as much as we care for them,” Sgt. 1st Class Kerstan Harrivel said Friday at a military rest area outside of Overasselt. Harrivel, who participated for the third time, was the U.S. Army Europe and Africa team captain. She said her team prepared by logging over 1,000 miles since January and completing other long-distance marches across Europe. Many marchers said temperatures and humidity posed an obstacle this year. Though not as hot as 2006, which saw the event canceled after the first day, the weather caused officials to modify Friday’s final march. Civilian routes were reduced a little over 6 miles and military marchers could complete their roughly 25 miles without a 22-pound rucksack. Carrying extra weight aside, some of the military participants said the march takes a big toll on the body. “A lot of military members come in with the notion that ‘I’m in the military, so I’m in good physical condition,’” U.S. liaison support officer Marine Lt. Col. Matthew Berthinet said Thursday. “It’s really an event that taxes different parts of your body than you’re used to working out.” Berthinet, who marched in 2022, added that preparing for the event is a time commitment with no shortcuts when it comes to putting lots of miles on your body and feet. Not everyone on the Space Force team made it to the Charlemagne rest area on Friday to earn their Vierdaagsekruis, or Four Days Cross medal. A few marchers were dropped for medical disqualifications through the first three days. But Baer said this shouldn’t be the last time people see the Space Force in Nijmegen. “There are enough guardians out there, so there’s no reason we can’t put together a recurring Space Force team,” Baer said after arriving at Charlemagne on Friday. “We’re gonna make it a thing.” After a short rest, marchers wearing their newly earned medals walked the final 3-mile stretch down Sint Annasstraat, known as the Via Gladiola, into downtown Nijmegen. The combination of parade and party saw Baer and company cheered on by thousands of spectators that showered them with high fives, hugs and cold drinks, as chants of “USA, USA, USA” rang out. Next year’s march will occur July 15-18, as Nijmegen celebrates hosting the event for the 100th time. The current head to head record for the teams are NEC Nijmegen 1 win(s) NEC Nijmegen and PSV Eindhoven have not drawn any of their last 14 matches against each other. Thomas Ouwejan has created the most big chances for NEC Nijmegen (8) Have scored 15 goals in their last 5 matches Ivan Perisic is ranked 3 in big chances created in the competition (8) 01 Feb 2025 20:00:00 GMT?NEC Nijmegen vs PSV Eindhoven on Sat 01 Feb 2025 20:00:00 GMT ended in a 3–3 tie.InsightsHave scored 8 goals in their last 5 matches NEC Nijmegen and PSV Eindhoven have not drawn any of their last 14 matches against each other NEC Nijmegen is playing home against PSV Eindhoven at Goffertstadion on Sat The protest took place at Zara’s store located at Plein 1944 in Nijmegen, where around 14:30 local time, the first activists were escorted out by the police. A spokesperson for the police confirmed that a small group of people experienced some irritation to their eyes but did not require medical attention. Three individuals were arrested during the protest. Prior to the protest, XR had requested permission from the municipality to hold the demonstration, but the action was prohibited. In response to the ban, XR proceeded with their protest anyway. A spokesperson for XR, 'Puk,' explained the symbolic nature of the action: “We wanted to show that this issue stinks. And Zara stinks too.” The activists used butyric acid, which emits a smell similar to Parmesan cheese, but much stronger. XR previously announced their intention to carry out similar protests across 29 municipalities in the Netherlands, but clarified later that this was an April Fool’s joke. The group only intended to hold the action in Rotterdam, though that plan was also abandoned. However, XR announced they would target other locations, and the action in Nijmegen was part of that effort. © 2012-2025, NL Times, All rights reserved. The current head to head record for the teams are FC Twente 12 win(s) Sem Steijn is the competition's top scorer (18) Have scored 11 goals in their last 5 matches Kento Shiogai has the most shots on target per match for NEC Nijmegen (2.3) 23 Feb 2025 13:30:00 GMT?FC Twente won 2–0 over NEC Nijmegen on Sun 23 Feb 2025 13:30:00 GMT.InsightsHave scored 11 goals in their last 5 matches FC Twente is playing home against NEC Nijmegen at De Grolsch Veste on Sun it was a vibrant meeting place for crafts from Nijmegen established names and talents yet to be discovered by a wider audience demonstrate the diverse and impactful legacy of the bronze foundry Everyone who knows Nijmegen a little can indicate the bronze elephant on the façade in the Priemstraat For thirty years the bronze foundry De Olifant was a melting pot of creativity and a meeting place for people who shared the same passion Artists who worked with De Olifant as their local base of operations made an impact Traces of it can still be seen today in Nijmegen the province of Gelderland and further afield Well-known bronze sculptors such as Ed van Teeseling Huib Noorlander and Andreas Hetfeld appear in a colourful combination alongside contemporary talents such as Nuhrzehra Ulukaya showing how diverse the legacy of De Olifant is The works in the exhibition tell the story of the bronze foundry For some it is a celebration of recognition for others a first introduction to a Nijmegen craft Medical chip expert Sencure has opened an R&D office at the Noviotech Campus in Nijmegen The company is headquartered in Roden and has an existing design site in Enschede The additional location ensures that it can continue to expand its team and projects while significantly enhancing the talent pool “We were looking to grow our chip design team,” states Sencure CEO Dick van Waes. “This new office in Nijmegen allows us to achieve that. Initially, five people will start there, with room for further growth.” The five are former employees of Goodix’s chip design center in Nijmegen, which has its roots in NXP Formerly ItoM Medical Sencure develops chip technology for medical devices and health-tracking wearables enables medical wearable biosensors to capture high-quality signals like ECG and EEG while operating on minimal power consumption This gives healthcare professionals invaluable insights into physiological conditions without sacrificing comfort or battery life Target applications include remote monitoring and diagnostics for cardiac Bits&Chips strengthens the high tech ecosystem in the Netherlands and Belgium and makes it healthier by supplying independent knowledge and information Bits&Chips focuses on news and trends in embedded systems Our coverage revolves around the influence of technology Bits&Chips uses technologies such as functional and analytical cookies to improve the user experience of the website. By consenting to the use of these technologies, we may capture (personal) data, unique identifiers, device and browser data, IP addresses, location data and browsing behavior. Want to know more about how we use your data? Please read our privacy statement. Give permission or set your own preferences The current head to head record for the teams are NEC Nijmegen 6 win(s) Haven't scored in their last 2 matches Go Ahead Eagles have won the previous 2 matches against NEC Nijmegen. Oliver Antman is ranked 1 in big chances created in the competition (11) 09 Mar 2025 13:30:00 GMT?Go Ahead Eagles won 3–2 over NEC Nijmegen on Sun 09 Mar 2025 13:30:00 GMT.InsightsHave scored 6 goals in their last 5 matches Go Ahead Eagles have won the previous 2 matches against NEC Nijmegen NEC Nijmegen is playing home against Go Ahead Eagles at Goffertstadion on Sun The current head to head record for the teams are Sparta Rotterdam 6 win(s) Carel Eiting has created the most big chances for Sparta Rotterdam (8) Have scored 6 goals in their last 5 matches 06 Apr 2025 12:30:00 GMT?Sparta Rotterdam won 2–0 over NEC Nijmegen on Sun 06 Apr 2025 12:30:00 GMT.InsightsHave scored 11 goals in their last 5 matches Sparta Rotterdam is playing home against NEC Nijmegen at Sparta-Stadion Het Kasteel on Sun you agree to the use of cookies in order to offer you content and services that are tailored to your interests Sommaire de la ficheShareFacebookMailFavoriteFermerContents as well as representatives based in the U.S The organisation currently brings together more than 1,000 French cinema and TV content professionals (producers etc.) working together to promote French films and TV programmes among foreign audiences Home » English » Commemorating the liberation of Nijmegen: ‘Striving for a balance between emotion and reason’ Nijmegen is celebrating 80 years of liberation A two-day festival reflects on the concepts of peace and freedom through the 'Peace by Peace' event The celebration is part of the longer program of '80 years of Freedom' Commemorating these events and making history more accessible to the broader public is important to many historians Most people have probably heard about and even participated in commemorative activities surrounding the Second World War be it by attending a traditional ceremony or through engaging with monuments and museums But not everyone is (actively) involved in fostering commemorative practices and making this history accessible Yet some have made it their priority to engage with this topic has engaged with commemorative practices and the ideas of liberation and freedom in the Nijmegen region since moving there in 2012 ‘The historical context of the border region particularly the Liberation Route (international remembrance trail that connects the main regions along the advance of the Western Allied Forces toward the liberation of Europe inspired me to become actively involved in bridging communities and reinforcing the importance of memory’ the American Studies professor has organised performative acts and taught about the cultural and transnational aspects of liberation the importance of commemoration stems from the complex emotions that surround the aftermath of war – out of profound sadness we can still find ways to celebrate life and joy,’ says Mehring While many European nations have commemorations for the events of World War Two The bombing of the city in February 1944 by American bombers was the deadliest on Dutch soil (763 dead ed.) and the liberation efforts by the Allies have gone down in history thanks to movies like A Bridge Too Far the Allied bombing was particularly devastating – not just because of the physical destruction but also because of the emotional and psychological trauma it caused Operation Market Garden further underscores the region’s pivotal role in the war leaving deep scars on the landscape and in the collective memory of the people is remembered as the most courageous and heroic actions of the Liberation of the Netherlands These events have shaped the memory culture of Nijmegen and emphasise the necessity of remembrance.’ ‘The Sunset March is a particularly important opportunity for international students to reflect on war reaching beyond classroom readings and discussions’ ‘During the RUDESA Spring Academy (a collaboration between Radboud University and University of Duisburg-Essen ed.) students from the Netherlands and Germany can experience this together and examine how the transatlantic memory culture manifests.’ ‘The aim behind the mural is to bring forth the civilian and human perspective of September 1944 collaborated with Radboud historian Joost Rosendaal and based this mural on diaries from people who lived in Nijmegen during that period the mural does not only showcase the devastation of this military operation children handing out apples to American soldiers immediately after the liberation of Nijmegen and a nun going around on her bike and helping the wounded bring out a very different dimension of the otherwise well-known event,’ explains Manders ‘Cross-border cultural exchanges have become integral to the healing process’ Commemoration is not only about the locals remembering the events He believes that it should also serve as a bridge between people that transcends national and ideological boundaries He also sees this happening in Nijmegen: ‘Cross-border cultural exchanges between the Netherlands and Germany have become integral to the healing process (after World War Two ed.) and it is through such transnational frameworks that we build lasting peace songs like Lili Marleen and We’ll Meet Again are striking examples of remembering the human stories behind the conflict They are speaking to universal themes of longing for peace Through creating these transnational links and connecting broader communities in remembrance we can build lasting peace.’ Commemoration of liberation is also an important way to learn from history and prevent future conflicts ‘Commemoration should teach us to be resilient against political ideologies that promote aggression This remains important also for younger generations who grew up without direct memories of World War Two – Mehring being one of them: ‘I grew up during a time of optimism in Germany and I recognize that it is easy to think that democracy and freedom are a given But freedom must be actively lived and practised – it is not something that comes automatically Commemoration offers a means for me and younger generations to engage with the realities of war and the fragility of peace reminding us all that democracy is a responsibility Manders thinks the Waalpaintings are a way to ensure that these stories and lessons of the past stay alive ‘The mural of Operation Market Garden is a way to bring awareness and also show that we do not want such tragedies to happen again.’ She believes that it is especially relevant to teach younger kids about these topics too: ‘Nowadays with all the political developments and polarization it is essential that we provide kids with tools to help them learn how to look at a specific event from different perspectives and understand the human aspects of war By including the Operation Market Garden mural in the curriculum it would be possible to show students the local experiences of World War Two and make the stories seem more alive and personal.’ Manders adds: ‘The graphic style of the mural was thus a purposeful choice for us It distances the violence to be appropriate for public space and younger kids but the choice of using slightly different stencils still brings forth the individuality of the people and stories depicted.’ Universities play an important role in commemoration the liberation too ‘They should work in a way to connect academic study and public engagement Through different transnational initiatives we can deepen students’ understanding of transatlantic memory culture and history by making the fight for our freedom up close and personal while fostering a sense of responsibility towards the future,’ Mehring explains ‘Not all forms of commemoration are productive – some can be overly sentimental or even politically charged’ academics can contribute their expertise and resources to bring to life the human histories and stories Mehring himself is working on several projects: ‘One of them is a bilingual book Faces of Liberation based on the Foundation Faces to the Graves where we aim to add a life story to each of the soldiers’ graves at the Canadian War Cemetery in Groesbeek This and other projects are ways to reflect on the past while also helping to foster a culture of remembrance across borders.’ Manders has a similar perspective: ‘We must bring academic research outside the university walls and generate discussions Projects like the Waalpaintings form a possible way to do that Not only can we bring more nuanced and inclusive historical narratives to the public but we can engage with the community – this brings so many different people together but also other community members who get involved we often talk with people on the street which brings up interesting stories and fosters conversation.’ While engagement with commemorative practices remains ever relevant it is also important to be aware that this must be done in a productive manner ‘We must strive for a balance between emotion and reason Not all forms of commemoration are productive – some can be overly sentimental or even politically charged Thoughtful commemoration should combine emotional resonance with a rational understanding of history to ensure that we are not merely swept away by affect but are also critically engaging with the lessons of the past.’ Peter Freijsen and street orchestra Kladderadatsch) and two anti-polarization workshops (with rhetoric experts Be Breij and Yvette Linders) This afternoon from 16:00-17:00, at MM 00.029, there is the “Locating American Studies” event with a keynote from Canadian Professor Dean Burry titled ‘Tracing Colville – A Multigenerational Canadian Exploration of Liberation Through Music and Art Tomorrow at 20:15 at De Vereeniging there is a liberation concert Tonight there is also a discussion by Erika Manders and Gerco Hiddink on the mural of Operation Market Garden and the way history is made visible in the public space Do you want to leave a comment? Please read our house rules. Your email address will not be published. It may take a while before your response is posted. Read our privacy statement if you want to know more about how we use your data daily or weekly update with our articles in your mailbox This can be done anonymously using the form Wij maken gebruik van cookies.Lees meer hierover in onze privacy statement websitebezoek en gebruik wordt gemeten en gebruikersgegevens worden anoniem verzameld The NOVA National School of Public Health (NOVA NSPH) took part in the Annual Meeting of the SAFEST project – Improving Quality and Patient Safety in Surgical Care through Standardisation and Harmonisation of Perioperative Care in Europe NOVA NSPH presented the work it has been doing particularly in terms of evaluation and monitoring which took place between 12 and 14 February in Nijmegen the partners analysed the progress made in all the Work Packages over the last year and defined the main priorities for 2025 and research fellows Ana Beatriz Nunes and Patrícia Sousa Paulo presented the work carried out within the scope of evaluating and monitoring the SAFEST intervention The team also highlighted the hosting of three master’s theses developed within the scope of SAFEST and the hosting of consultancy internships for the Public Health Medical Internship reinforcing NOVA NSPH’s commitment to training highly qualified health professionals The final days of the Annual Meeting were dedicated to the hospitals participating in the SAFEST project with representatives from all the institutions involved present The hospitals presented their progress in implementing the Quality Improvement Collaborative as well as the main challenges and facilitating factors in the process who shared their experiences in the perioperative context providing an essential perspective for the continuous improvement of surgical care Participants also had the opportunity to visit the operating theatre at Radboudumc Hospital where they were able to observe the briefing and time-out moments The NOVA NSPH team presented the first preliminary results on adherence to SAFEST practices and the incidence of surgical complications in SAFEST hospitals The SAFEST project has received Horizon Europe funding and will run for four years. It is being developed by NOVA NSPH researchers Paulo Sousa Pedro Casaca Carvalho and Patrícia Sousa Paulo Receive all the news and highlights from NOVA NSPH a combat medic assigned to Headquarters and Headquarters Company poses for a photo during the Nijmegen March in Nijmegen “I find it interesting each time I get to work alongside our multinational partners and allies because every single time I find myself learning something new technique wise that I could add to my toolbox to use later,” said Christie about the event This work, Nijmegen March Spotlight: Spc. Stoney Christie, by SGT Omar Joseph, identified by DVIDS, must comply with the restrictions shown on https://www.dvidshub.net/about/copyright OneFootball's home page Search Settings Sign In Sign InJoinNEC Nijmegen v RCK Waalwijk Preview: Waalwijk looking to boost Eredivisie survival chances | OneFootballGet Belgian & Dutch Football News For NEC a victory would go someway to ensure they are not suddenly drawn into a battle to avoid finishing 16th They are currently six points ahead of Willem II and will be eyeing this game as one to win and increase the gap The side have won just one of their past nine games although during this run they did draw with PSV and beat FC Utrecht away from home Last time out they lost 2-0 away to Sparta Rotterdam They will have to face Waalwijk without their key player from the campaign so far The 29-ear-old midfielder is having one of the best seasons of his career with nine goals and four assists in 23 games He still has some way to go to beat the 14 goals and 12 assists he managed for Sparta back in the 2022/2023 campaign In the reverse fixture back in November it was NEC who were victorious by a score line of 3-0 GBeNeFN | Ben Jackson Related NewsNEC Nijmegen v Willem II Preview: Will replacing Peter Maes give relegation threatened Willem II a chance of survival? Feyenoord confirm the arrival of Eredivisie star Sem Steijn from FC Twente 4️⃣ things to look out for in the Champions League this week The Champions League returns with a bang this week as the finalists will be determined following some tense first leg action.Here is what to look out for...⚔️ Match of the... Man United hold talks in “recent hours” with Victor Osimhen’s agents over sensational summer deal The three players Xabi Alonso has requested Real Madrid to sign – report Mayor Hubert Bruls of Nijmegen on Saturday condemned a protest action by climate group Extinction Rebellion (XR), calling it “disgraceful” after activists poured stinky butyric acid on themselves inside a Zara clothing store in the city The action was part of a broader XR campaign targeting fast fashion retailers in 29 Dutch municipalities While the group later claimed the protest was an April Fools’ prank it admitted that one real incident involving the use of the foul-smelling chemical would take place “We had already labeled XR earlier this week as an unpredictable and unreliable organization,” Mayor Bruls said in an official statement following the protest “Their claim that it was an April Fools’ joke was not taken seriously and police and enforcement personnel remained alert to XR’s announced action Bruls had proactively issued a ban earlier in the week specifically prohibiting the distribution of butyric acid within the city XR activists carried out the act in a busy retail location Police arrested three individuals connected to the incident The mayor emphasized that the city had anticipated the group might follow through with its plans despite the ban The demonstration caused disruption inside the Zara store though no medical attention was required on site By contrast, a similar XR protest in January at an H&M store in Naaldwijk resulted in several people feeling unwell due to the odor Those affected were treated by ambulance personnel Saturday’s incident did not require emergency medical services Zoetermeer Mayor Michel Bezuijen also voiced his frustration with XR after the group falsely announced a protest in his city that turned out to be part of the prank “It’s a waste of valuable time and resources,” he said “Municipal authorities and police still had to prepare Trust in these types of notifications is undermined when it turns out to be a bad joke.” The controversial Palestinian activist Mohammed Khatib will still speak at Radboud University in Nijmegen on Monday, lecturer Harry Pettit, the organizer of the address, wrote on X. “He will not be silenced,” Pettit said, referring to the Dutch government barring Khatib access to the Netherlands during a pro-Palestinian demonstration in front of Radboud University’s Spinoza building Radboud University told Trouw that it was “not familiar” with the exact plan Khatib can’t enter the Netherlands so the only real possibility is an address via video screen “We are following the developments and trying to interpret them as best as possible,” the spokesperson said the Dutch government banned Khatib from entering the Netherlands Khatib indicated that he planned to appeal against the entry ban that summary proceedings have not yet been filed Neither Khatib nor Pettit were available to comment to Trouw on Sunday evening Khatib’s entry ban is not without controversy The Dutch Immigration and Naturalization Service (IND) previously concluded that there was “insufficient legal basis” to declare Khatib an undesirable alien 31-Mar-2025 Last updated on 31-Mar-2025 at 11:45 GMT Similar meat advertising bans have been implemented by municipalities in Haarlem and Utrecht with the ban set to come into force this year The Party for the Animals in Nijmegen has long supported banning adverts for polluting products and services in public spaces and includes meat and dairy products in this definition alongside fossil fuels Nijmegen has also endorsed the Plant Based Treaty becoming the 37th city around the world to do so alongside Los Angeles More than 4,000 businesses and organizations and more than 230,000 individuals also support the Plant Based Treaty which is based around the core principles of relinquish Each principle is focused on contributing to a more sustainable food system and a better climate and together encompass an end to intensive livestock farming the promotion of a shift to a plant-based food system and ecosystem restoration we put the Plant Based Treaty on the city’s radar,” said Bart Salemans a Party for the Animals representative on the Nijmegen city council The city of Nijmegen issued a statement to accompany the Plant Based Treaty endorsement and consume food has a major impact on the health of humans and the planet and contributes to the climate crisis,” the statement said “The municipality of Nijmegen supports these principles and is actively committed to healthy and sustainable food the Agenda Circular City 2030 and the Vision on Health Nijmegen 2040 will be established various initiatives within the municipality of Nijmegen are already aligned with these principles.” a multi-partner project that includes universities and restaurants is launching the Nimma Sandwich with all ingredients sourced from local farmers and producers in turn contributing to Nijmegen’s goal of achieving a protein transition and shortening supply chains The city has also committed to serving more plant-based food in its canteens We applaud Nijmegen for showing climate action leadership by endorsing the Plant Based Treaty Also read → Lidl announces recall due to Salmonella contamination Taylors Snacks launches three new flavours exclusively to Lidl31-Mar-2025By Gwen RidlerScottish crisp manufacturer Taylors Snacks is launching three new flavours exclusively into Lidl stores this month ahead of a nationwide rollout later this year. Meet the UK Food Strategy Advisory Board31-Mar-2025By Bethan GryllsThe newly formed Food Strategy Advisory Board (FSAB) met last week for its first meeting and has brought together senior leaders across the food system to advise on a clear vision and framework for the UK food system. Naked Wines founder steps down with immediate effect31-Mar-2025By William DoddsThe founder of Naked Wines is stepping down from his role as chair with immediate effect. Sharing innovation for net zero gainPaid for and content provided by European Union Why food and drink manufacturers need to embrace – rather than fear – artificial intelligencePaid for and in partnership with QAD Redzone From waste to worth: how F&B manufacturers can turn challenges into strategic winsPaid for and content provided by Biffa The game in Nijmegen drew a crowd of about 800 Security personnel and stewards attempting to defuse the situation sustained injuries A police spokesperson confirmed that the cause of the initial altercation remains unclear “It became increasingly chaotic when people were asked to leave the venue,” the spokesperson said The violence spilled outside the rink after the game Police intervened with batons and forcibly cleared the square outside the arena Two individuals were arrested for insulting officers and incitement Authorities noted that some involved were reportedly fans of the local soccer club NEC Nijmegen The turmoil in Nijmegen reflects a broader problem within Dutch ice hockey IJshockey Nederland has cited a disturbing rise in violent behavior across senior leagues as the reason for issuing a stern warning to its clubs The organization highlighted a pattern of physical fights and even threats directed at officials and players “The season has just started, and already we are seeing an alarming increase in unacceptable behavior,” IJshockey Nederland Director Theo van Gerwen wrote in a letter to clubs “These incidents contradict the values we want to promote in our sport.” Van Gerwen described the time-consuming nature of managing recurring incidents revealing that he and his staff spend up to 20 hours weekly addressing violent episodes with clubs and liaising with prosecutors Van Gerwen linked the rise in aggressive behavior to broader societal trends and that mirrors itself in our games,” he said The governing body has urged clubs to host awareness sessions and foster a culture of respect Former Dutch record-holder Ron Berteling noted that violence has long been ingrained in ice hockey culture but emphasized that the lower leagues have seen an intensification of such behaviors “It’s as if some of these recreational teams think they are playing in the Champions League final,” he said Berteling urged clubs to take responsibility for educating players about sportsmanship “Beautiful memories in this sport come from camaraderie urging clubs to adopt internal sanctions for unruly players and promote dialogue over punishment While referees have been instructed to crack down on fights by issuing automatic suspensions Van Gerwen suggested that stronger player engagement might yield better results one of the country’s largest ice hockey clubs imposing additional penalties on players guilty of misconduct Berteling and others warn that completely eradicating violence from such a physically demanding sport may prove unrealistic The implications of unchecked violence extend beyond the rink Van Gerwen expressed concern about the potential impact on recruitment and retention in a sport already grappling with limited participation “If verbal abuse and physical confrontations dominate we risk losing players and referees,” he said The federation has already banned body-checking in lower divisions to minimize injuries citing disparities in skill levels among players as a safety risk noting that players often have commitments outside the sport “No one wants to show up at work on Monday with a black eye or a broken nose,” he said they are perhaps one of the most powerful forces a society can bring together”—Charlie Amid the immense human tragedy unfolding in Gaza students and faculty members at Nijmegen Radboud University in the Netherlands Hundreds of students and faculty members participated chanting “Free Palestine,” “Cut the ties,” “Disclose and divest” and “From the river to the sea Following protest rallies and encampments at universities in Amsterdam students and faculty members at Nijmegen demanded an immediate end to the genocide in Gaza They accused the university administration (CvB) of being directly complicit in the ethnic cleansing of Palestinians by maintaining ties with Israeli institutions and defence industries Radboud University faculty members have written an open letter in support of the students’ demands expresses political solidarity with the students camped in front of the Maria Montessori building on campus grounds since May 13 On the other end of the barricade engaging in class war has consistently shown its political approval for the war crimes of the Netanyahu regime against Palestinians as an act of “self-defence.” The students and faculty members at the university are well aware that the terminology of “self-defence” is a political blank cheque for the fascistic regime in Tel Aviv to carry out the “final solution” to the Palestinian question As tens of thousands march in the country against the genocide and the complicity of the Dutch ruling elite and its institutions, a coalition of Geert Wilder’s far-right Freedom Party (PVV), Pieter Omtzigt’s New Social Contract (NSC), Caroline van der Plas’ Peasant Citizens Movement (BBB) and the Liberals (People’s Party for Freedom and Democracy, VVD) of Mark Rutte has agreed on a new government They are about to appoint Dick Schoof as the next prime minister the 67-year-old former Dutch Labour Party (PvdA) member and alumnus of Nijmegen Radboud currently holds the highest position at the Ministry of Justice and Security Under previous Rutte governments he served as the head of the Dutch General Intelligence and Security Service (AIVD) the Counterterrorism and Security Agency (NCTV) and the Immigration and Naturalisation Service (IND) Appointing Schoof as the next prime minister who has an infamous record for stomping on democratic rights sends a serious political warning to the working class and protesting students His appointment serves as a conclusion to the 26-page coalition agreement titled “Hope The World Socialist Web Site (WSWS) has pointed out that the agreement is a “declaration of war on the working class and all forms of social and left-wing opposition.” The agreement has two central goals: the introduction of the “toughest asylum law ever” and the establishment of a police state The events of the past few weeks have substantiated the analysis provided by the WSWS the Dutch bourgeoisie is in favour of appointing a former intelligence chief as the head of its new police state The WSWS spoke to the students at Monday’s protest, sharing a QR code linking to the statement: “The assault on Rafah and the ethnic cleansing of Palestine.” Our university has direct ties with Israeli universities; they are part and parcel of Zionist ideology which is that of ethnic cleansing and Judaization states that unprecedented force can be used against Palestinian civilians as retaliation for the murder of Israeli citizens This imbalance in the value of lives means we now have a situation in which 40,000 Gazans are being murdered in a genocide of retaliation when you know what your university is doing the Netherlands has had close ties with Israel and 76 years of Dutch complicity in genocide a former Royal Dutch Army private and MP of Geert Wilders’ PVV to ban the slogan “From the river to the sea” as “antisemitic” and as a “criminal incitement for violence.” On May 21 the motion was passed by 74 to 73 votes We don’t use the slogan “From the river to the sea!” in terms of a Palestinian ethno-national state We use the term and will continue to do so because it represents a future brighter than ethnic and religious divisions and an ethno-national state and it leads to ethnic cleansing as we can see now We have huge support from staff members—in 48 hours We have massive support from the Nijmegen community We saw the Belgian dockworkers blocking arms shipments to Israel which gave us great inspiration and courage because you can see workers saying “No we will not take part in it.” If students and workers are united they are perhaps one of the most powerful forces a society can bring together who preferred not to be photographed due to security concerns She was deeply emotional and found it difficult to articulate her thoughts on the dire situation facing the Palestinian people I have a friend in Gaza and I have daily contact with him He told me to keep the global movement going and educate people on what’s going on in Palestine What is happening in Gaza is now being normalized Now there are no hospitals left in Gaza; burning babies is being normalized burning people alive is being normalized .. Aisha rejected the narrative that the protesters were “antisemitic,” adding “There are a lot of Jewish people taking part in this protest and many of them are taking the lead as well calling the protests ‘antisemitic’ is outrageous.” According to a spokesperson for the protest security guards at Radboud University forcefully pushed two protesting students to the ground and placed them in a neck-lock The students were subsequently turned over to the police a large number of police entered the Erasmus building at the university grounds to end the occupation by 50 students on its second floor The riot police broke the barricade and dragged the students out of the building riot police encircled a large group of pro-Palestinian demonstrators and arrested 73 of them and laid draconian charges of “criminal offences.” The recent attacks on protests against genocide in the Netherlands and internationally highlight the link between imperialist foreign and domestic policies These brazen attacks not only undermine core democratic rights As US President Joe Biden signed a record military budget of over $825 billion to fund the US/NATO war in Ukraine, to arm Israel, target Iran and prepare for war in East Asia with China, the Dutch bourgeoisie is preparing its own battle plan for global war Ukraine is set to receive an additional €400 million in military support from the Netherlands in addition to the €2 billion already allocated for 2024 the government has already allocated €1.5 billion for Ukraine for 2025 In addition to the billions already allocated to Kiev the 2024 defence budget is projected to increase by nearly 43 percent This war budget is expected to rise annually reaching an initial sum of €21.4 billion by 2030 which is approximately 2 percent of the Dutch GDP This is proposed to be enshrined in the constitution to place Netherlands on a perpetual war footing staff at the University of Amsterdam (UvA) established their first staff encampment in support of their students One among them is Associate Professor Sruti Bala from the Faculty of Humanities and Theatre Studies In her widely circulated Instagram clip from the staff encampment she insisted “This is not a freak bunch of hysterical nutters who watch too much social media But this is a movement of academics as public intellectuals who stand up for issues that matter in society.” is particularly concerned that the student protests could incite the Dutch working class to engage a struggle against imperialist war what initially started as a student protest is now gaining momentum and attracting a broader section of the working class to the anti-war and anti-genocide movement starting from faculty members to workers in the immediate university encampment neighborhoods in the big cities Developments this week indicate that workers in industrial neighborhoods also have begun to organise themselves into independent networks exclusively through social media with close ties with university encampments especially in terms of appeals for safety against police crackdown as well as for funding resources and expertise and not less to promote an independent media coverage to cut across the official media campaign of slander against the anti-genocide protests Dutch students and workers must turn to the international working class and base themselves on a socialist perspective directed against police state measures at home imperialist militarism abroad—of which the genocide in Gaza is a part—and against its source Fill out this form and we’ll contact you soon Home » English » Programmes move away from English but in Nijmegen ‘controlled growth’ of international students remains possible Dutch universities are willing to admit fewer international students provided that the government remove the threat of a ‘language assessment’ for undergraduate programmes it is expected that Nijmegen will still be able to achieve controlled growth in the number of international students The universities have already promised to reinstate Dutch as the language of tuition for all their psychology programmes in the major cities And universities across the country say they will admit fewer students to English-taught undergraduate programmes The universities estimate that there will soon be 2,000 fewer international Bachelor’s students at Dutch universities compared to the peak year 2022/2023 This puts the total number of international first-year students at around 16,766 (This process has already begun: that total represents a reduction of 700 compared to the current academic year.) The universities acknowledge the problems associated with the influx of large numbers of students from abroad: some programmes have become overloaded while several cities face a chronic lack of student accommodation the universities have set one condition before agreeing to take matters into their own hands They want the government to scrap its plans to assess the need for ‘foreign language teaching’ in existing undergraduate programmes the government wants to filter out what it sees as excessive English-language tuition in undergraduate education: does English serve a purpose or would the programme be just as effective in Dutch According to the terms of its new bill Internationalisering in balans (Internationalisation in Equilibrium) all higher education programmes should be held to this standard It is striking that Nijmegen is going against the national trend. At Radboud University, controlled growth in the number of international students is possible in the coming years, according to a message on the university website This is because Radboud University has relatively few international students the university is located in a region with a shortage of highly educated international staff Study programmes in Nijmegen therefore do not have to abandon English as the language of instruction This academic year, 2,490 international students are enrolled at Radboud University That is a decrease of 3.5 percent from last year international students make up 10.3 percent of Radboud University’s student population NSC and BBB wanted to save 293 million euros a year by reducing the number of English-taught programmes which in turn would reduce the number of international students Following a compromise with the Christian opposition parties and JA21 this annual saving fell to 168 million euros with more than 60 percent affecting the universities and the rest impacting universities of applied sciences The universities accept that a language assessment makes sense for new programmes but see no point in applying it to existing programmes it can only increase red tape and plunge higher education into uncertainty: it could be years before universities know which programmes will be allowed to continue As long as the threat of a language assessment remains the universities are unwilling to take action themselves That would mean making sacrifices only to face the possibility of a ‘second round of amputation’ says president of Universities of the Netherlands Caspar van den Berg in an online press conference Progress would be more efficient and effective if the politicians left them to it But exactly how much do individual universities plan to cut This will be done on a ‘pro rata basis’ president of Utrecht University and a driving force behind the universities’ plan he declines to mention exact numbers and percentages The growers include Bachelor’s programmes in areas such as STEM where the Dutch labour market has a real shortage of graduates the universities want to be able to recruit more international students Eindhoven and Wageningen say they will act ‘in solidarity with the other universities’ by converting a small English-taught programme to Dutch Other universities could easily resent the scope being given to the four universities of technology to attract students from abroad Eindhoven and Wageningen say they will act “in solidarity with the other universities” by converting a small English-taught programme to Dutch or discontinuing it altogether The University of Twente has made no such pledge The House of Representatives’ education committee is due to debate this issue next week which explains the timing of the universities’ proposal the education minister still needs to work out how to meet opposition demands to soften the impact of his higher education cuts in border regions and areas with a declining population The universities have no intention of formalising their plan in a fixed agreement with the government Not least because the government recently abandoned a previous agreement which promised them additional funding; the universities are now taking legal action to reverse that decision the universities will enter into mutually binding agreements Home » English » Nijmegen administrators and residents benefited from slavery Nijmegen administrators and residents benefited from slavery for several centuries That is the conclusion of a Radboud University research study into Nijmegen's colonial slavery past the current university campus is located on the former property of a Dutch East India Company (VOC) administrator Not a lot of research had been done on Nijmegen’s slavery history Nijmegen historians Coen van Galen and Joris van den Tol concluded when asked by the municipality to investigate Nijmegen’s colonial past Together with junior researchers Lianne Wilhelmus and Luc Meijboom, they studied the interests and positions held by Nijmegen administrators between 1596 and 1873, revealing a strong connection with the colonial economy and associated slavery. This led them to write a book that is now available in open access The abridged public version will be distributed around the city ‘You have to see the administration in those days as kind of oligarchs,’ explains Joris van den Tol ‘The mayor and council promoted their own economic interests and those of their families through administrative positions.’ Even though Nijmegen was landlocked the city did play an important role in colonialism ‘Nijmegen was the most important city of the most prominent region of the Dutch Republic This enabled the city to put forward chairs of committees in the States General and administrators for the VOC and WIC.’ The governors were administrators within the Dutch East India Company (VOC) and the Dutch West India Company (WIC) acting as a link between the States General and these trade organisations Lacking biographical information on the Nijmegen administrators the researchers delved into minutes and trade information records of sales of oxen and timber to the WIC and VOC ‘Wood was used for the ships and oxen were shipped to the plantations to power sugar mills,’ says Van den Tol ‘Oxen from Nijmegen were shipped to the plantations to power sugar mills’ Goods landing in the western Netherlands were transported to Germany via Nijmegen And the same applied vice versa for exports.’ ‘This made it possible for Nijmegen to develop a processing industry adding value to goods in order to re-export them for more money we find French refugees starting a cloth trade in Nijmegen and being helped by the municipality to child labour from orphanages.’ ‘There was some debate about it within the Republic especially during the Eighty Years’ War but we found no evidence of this in Nijmegen.’ Joris van den Tol: ‘On the contrary you find articles opposing the abolition of slavery and it is clear from the coverage that everyone knew what was happening in Suriname down to the last detail.’ Enslaved people were also to be found in Nijmegen They were brought to the city by people who moved to Nijmegen from the colonies Since slavery was banned in the Netherlands but it is questionable whether they knew that There are at least three known cases of enslaved people in Nijmegen One of them was a man called Sedin who came to Nijmegen from the Indonesian island of Madura as a servant of the Van der Zwaan family Renowned regent families such as the Singendonck, Sweers and Swaen profited from the economic activities surrounding slavery The researchers felt it was important to show this interconnectedness ‘This offers a different take on Nijmegen’s history one that will hopefully be taken further in future,’ says Coen van Galen The researchers’ book is full of examples of Nijmegen’s political and economic interests But also of Nijmegen residents who went off to try their luck in the colonies There even appears to have been a VOC ship named Nijmegen which sailed to Asia but was shipwrecked just before returning to the Netherlands The study also provided a geographical link to the university campus. Adam Jacob Smits (1685-1742) was alderman (administrator) in Nijmegen for almost 30 years and mayor twice. He was also a governor in the WIC and VOC on behalf of Gelderland. He invested in the companies and even managed to have one of the company’s ships, Heerlijkheid Horssen which he expanded with heathland and forest The area currently houses the campus and hospital The research study offers starting points for much follow-up research as well as the role of the nobility on the whole He concludes: ‘And I am of course curious to hear the city historians’ response to this book.’ The research study was handed over to Mayor Hubert Bruls on Wednesday evening, 19 March. ‘The study’s conclusions are poignant. It’s heart-wrenching to hear what people did to each other, also people from our city,’ Bruls said in a press release A lecture and discussion on colonial slavery will be organised for residents later this year Nijmegen’s city administrators were partly responsible for making slavery possible and profiting from it during the colonial times This was the conclusion of researchers at Radboud University in Nijmegen who were assigned by the municipality in autumn 2024 to look into the city’s past of slavery The influence of Nijmegen’s administrators was more significant than other comparable Dutch cities This came partly due to the role that the city played in what was then the Republic in 1795 Administrators were also economically involved with slavery the city received slave goods and delivered these to the slave owners The city also delivered products that were necessary for the Dutch colonial empire Nijmegen and the city’s residents profited financially from colonialism and slavery As it was considered the most important city in the region at the time City administrators came to hold key positions and thus had a lot of influence in committees such as West Indian Affairs was impacted by the results of the research “It chills your heart when you hear what people have done to each other “Nijmegen's administrators had a special administrative position of power as the most important city in an influential province Even though this took place in the spirit of the times what we know does not make it any less sad and horrible." The municipality will further study the research and talk to residents in the near future This comes two years after a workgroup called on the municipality to recognize and acknowledge its role in slavery there was no clear view of how significant the city administration was involved in colonialist slavery Recent research now proves that slavery was “directly and indirectly intertwined with the administration and the economy” of the city Other cities have also conducted research into their role in slavery in recent years Several municipalities issued apologies for their role in slavery as a result of the research Sign InJoinBryan Linssen returns to the Eredivisie with NEC Nijmegen | OneFootballGet Belgian & Dutch Football News and helped Arne Slot’s side reach the inaugural UEFA Europa Conference League final The 34-year-old also boasts of experience with VVV-Venlo, Heracles Almelo, Groningen and Vitesse – with more than a hundred goals in over four hundred matches in Dutch professional football Linssen signed a one-and-a-half-year deal until the summer of 2026 with technical director Carlos Aalbers delighted about the acquisition: “Bryan knows the ropes and the Eredivisie inside out With this he can help our team to quickly get back on track for the second half of the season.” NEC Nijmegen are currently 12th in the league standings with 17 points. Their next game as the season restarts this coming Saturday sees them travel to face PEC Zwolle who sit a place below in 13th GBeNeFN | Max Bradfield Related NewsChelsea are chasing €60 million rated Man United target Bryan Mbeumo “Interest hasn’t gone away” – Former Man Utd chief says Red Devils could sell player to Chelsea Manchester United prepared to make a move for Brentford forward Bryan Mbeumo Manchester United Eyeing Move to Sign £60m Premier League Star – Report Genoa vs. Milan throwback: Pulisic goal, Maignan red, Giroud in goal – video Architect and Interiors India Home » News » Unveiling Winkelsteeg’s newest addition: A sports and residential complex fusing Nijmegen’s buzz with Goffertpark’s peace The new Winkelsteeg sports and residential complex located near Goffertpark and Goffert station is designed to connect the vibrant energy of Nijmegen with the tranquility of nature in nearby Goffertpark Its excellent location makes the complex highly accessible offering the ideal balance between active sport and green relaxation As part of the broader master plan “Winkelsteeg,” it sets the tone for Nijmegen’s urban transformation towards 2035 aiming to strengthen the connections between surrounding neighborhoods and landscape areas For this unique development in sports and housing in Nijmegen Under the leadership of Burgland Bouw as the municipality’s contract partner the sports building and parking solution are being developed Together with Hellebrekers and Slangen+Koenis Architects while Slangen+Koenis Architects is responsible for the integrated total design Along with the partners Orange Architects and Felixx Landscape Architects & Planners they have developed the concept for the entire plot Our team has created a holistic vision that gives Nijmegen a sustainable and future-proof impulse for the area Our shared goal is to create an integrated sports and residential complex that perfectly suits Nijmegen’s context The design combines varied building heights and dynamic shapes to create a smooth transition to the surrounding nature A 60-metertall building serves as a striking landmark forming a gateway to the Winkelsteeg neighborhood alongside the adjacent “52 Degrees” tower The gradual height build-up allows the complex to seamlessly blend into its surroundings The result is a balanced and welcoming architecture that creates a pleasant living environment for residents The grand 50m competition pool is clearly designed and puts the focus on swimming The materialisation creates a warm and inviting atmosphere with views of the green hills through the windows Nijmegen’s rich geological history guides the aesthetic choices of the design Inspired by the local moraines with the sand deposits of the last ice age the volume and facade materialization reflect the structures and different layers of the subsoil the exterior subtly references the soil layers that form Nijmegen’s landscape This natural inspiration reinforces the bond between the building and its surroundings with an extensive network of green spaces that contribute to biodiversity and a pleasant residential and living climate and green hills around the building create a continuous interaction between the city and nature This green design offers space for relaxation and recreation while also serving functional purposes such as rainwater buffering and temperature regulation This sustainable approach not only supports climate goals but also enhances the livability and identity of the complex and its specific landscape surroundings and recreation within a landscapeoriented environment Living spaces are designed with attention to daylight and energy efficiency and the sports center offers high-quality facilities for sports events Special attention has been given to the design of sports halls and swimming pools and optimal acoustics create an inviting and functional space The central restaurant provides a vibrant meeting point where visitors can enjoy views of both the sports facilities and the green surroundings.The main entrance from up close with a spacious entrance square The parking system is an essential part of the design with an underground parking garage allowing above-ground space for nature The efficient parking facility and well-organized traffic flows make the complex accessible and user-friendly The entrances for cars and bicycles are strategically placed making navigation within and around the complex intuitive and easy which contributes to a pleasant user experience Between the main entrance of the sports centre and the residential tower is a spacious ‘pocket park’ that slopes upwards towards the restaurant The transparent end façade invites you to come in for a drink The building design emphasizes sustainability and climate adaptation Using passive climate strategies such as green roofs and strategically placed vegetation the building remains cool with efficient use of energy Rainwater collection and infiltration support resilient water management while the green surroundings improve air quality and the living environment The smart layout of functions and use of sustainable materials make the complex energy-efficient and future-proof In addition to plantings for aesthetic and functional purposes the design also supports an ecosystem for animals such as birds Diverse plant species create an appealing habitat that supports healthy biodiversity Birds and insects find natural nesting areas and food within the complex while nesting boxes and other measures enriches the local fauna This ecological design promotes sustainable harmony between the city and nature The interior design combines warm earthy tones with wood accents creating a calming and natural atmosphere that harmonizes with the surrounding nature With subtle accent colours and carefully chosen materials the interior evokes a sense of peace and harmony enhancing the experience for users and visitors wooden roof structures and columns emphasize the warm character of the complex while smart layouts ensure a lively and open ambiance The spacious main entrance is a pivot between all sports functions and integrally connected to the restaurant with visual connections Nijmegen is making great strides in facilitating an inspiring fusion of city and nature an environment is created that naturally embraces and invites residents and visitors The project reflects Nijmegen’s ambitions and serves as a model for future-proof urban development the team not only creates a new living environment but also makes a valuable contribution to the quality of life for the city and its residents Attractive (interactive) spray objects and a slide provide entertainment in the play area the adjacent catered terrace provides good views on the playground while enjoying a snack NetherlandsDuration: 2023 – 2028Assignment: Design & Build + urban planning visionSurface area: 40.000 m2 (sportcentrum) + 20.000 m2 (visie)Program: sports hall commercial spaces (vision)Client: Municipality of NijmegenProject Team: Burgland Bouw Felixx Landscape ArchitectsVisualizations: DMOO Subscribe to our newsletter for the latest updates