The owner of the hotel on Van Vredenburchweg told Omroep West "You can see a man walking up without any facial covering Witnesses reported hearing three gunshots before seeing the shooter run past them and he showed it to me before running off into the park nearby." The park is adjacent to the hotel where the shooting occurred Önal was also reportedly in possession of compromising tapes of high-ranking Turkish politicians including members of President Erdoğan’s ruling party and had allegedly made enemies within the political and criminal worlds He was suspected of being the mastermind behind the 2022 murder of Halil Falyali a Turkish Cypriot businessman and gambling magnate due to his alleged involvement in money laundering and drug trafficking Earlier reports suggest Önal had recently provided information to U.S authorities about certain Turkish politicians which may have placed him in significant danger It is unclear whether this played a role in the shooting The shooter reportedly made little effort to disguise his identity Described as a man approximately 1.80 meters tall he approached Önal and shot him from close range before fleeing the scene Eyewitnesses stated the shooter appeared calm and deliberate in his actions Police immediately launched a large-scale manhunt utilizing a helicopter and issuing a public appeal for witnesses Authorities have set up a special investigative team to track down the suspect The police have been combing through the area and have cordoned off the crime scene with tape The police have confirmed that the victim was a 41-year-old Turkish man but have not yet confirmed his identity A significant number of investigators are working on the case including members of a special team dedicated to major crime investigations the hotel has been shut down for the investigation who was about to check in with his girlfriend "We were supposed to stay here for four nights The police are urging anyone who witnessed anything unusual around the Van Vredenburchweg area at the time of the shooting to come forward Authorities have also requested anyone with information about the suspect’s whereabouts to contact them directly ING CEO Steven van Rijswijk was interviewed by CNBC live from Davos last week He gave his views on what needs to happen in Europe to improve competitiveness and productivity and how he sees consolidation among European banks “What we see in Europe is that there’s different regulation on different elements This hampers us in doing efficient business with our customers and in the end it also has an impact on customers,” said Steven on CNBC “It impacts the level playing field for European banks compared to banks for example in the US a 41-year-old man was shot and killed on a hotel terrace at Van Vredenburchweg in Rijswijk The police call for witnesses of a fatal shooting that took place on Thursday outside of a hotel at Van Vredenburchweg in Rijswijk The victim was said to have been shot at close range A large-scale investigation team led by a public prosecutor has been set up to investigate the shooting The police call for witnesses The police want to get into contact with anyone who some anything near Van Vredenburchweg around 5.45 p.m. The shooter was described as a bearded man around 1.80 m tall with a normal to heavy build wearing black clothes. Did you see anything A 41-year-old man fatally shot on a hotel terrace in Rijswijk had previously reported threats to Dutch authorities and was awaiting possible extradition to Turkey, where he was accused of murder, officials confirmed to NOS. The victim, identified as Cemil Önal, was killed in broad daylight around 5:45 p.m. on a crowded terrace by a man dressed in black who fled the scene. Police say the suspect remains at large. “We are still actively searching for the perpetrator,” a police spokesperson said. Önal had filed a formal report warning of possible threats to his safety, the Dutch Public Prosecution Service (OM) confirmed. In a legal proceeding, his attorney stated that Önal feared for his life because of alleged ties to the Gülen movement—a group labeled a terrorist organization by the Turkish government. According to the lawyer, Önal had once sheltered a member of the movement, who was then a political refugee. Önal had recently been released from custody in the Netherlands and was awaiting a decision on his extradition to Turkey, where he was charged in connection with a 2022 double homicide in Northern Cyprus. One of the victims in that case was Halil Falyali, a businessman who operated luxury hotels, casinos, and gambling websites. Turkish prosecutors accused Önal of being Falyali’s longtime financial manager and claimed he may have orchestrated the killing. Önal denied any involvement. His attorney disputed the charges, saying, “Client worked for the company of a major mafia boss who blackmailed top-level Turkish politicians and was likely murdered as a result. Now the Turkish authorities are trying to pin the murder on my client.” Önal also resisted efforts to surrender his confiscated phone, which his lawyer said might contain sensitive information about his alleged ties to the Gülen movement. “If the Turkish authorities get hold of this phone, it will affect his trial. He will be at risk,” the lawyer stated in a motion opposing the phone’s transfer. That objection was denied. Investigative platform Follow the Money reported earlier that Önal had disclosed to Dutch authorities that he was in danger. Journalist David Davidson, who had been researching Falyali’s gambling empire, confirmed he had spoken with Önal multiple times since his arrival in the Netherlands. Their last meeting was Monday at a restaurant in The Hague. “He feared an attack on his life,” Davidson told NOS. “He suspected it would come from the direction of the Turkish state. But he was someone within a criminal organization and may have faced danger from multiple sources.” According to Davidson, Önal had indicated he possessed damaging information about corruption involving politicians—data collected by his former employer. Önal reportedly believed that this information put him at greater risk. The Dutch OM confirmed both Önal and his attorney had reported potential threats and filed a criminal complaint. However, the agency said there were not enough leads at the time to justify opening a broader investigation. “The OM and the police were in frequent contact with the victim and his lawyer,” an OM spokesperson said. © 2012-2025, NL Times, All rights reserved. Our Standards: The Thomson Reuters Trust Principles., opens new tab Thomson Reuters , opens new tab Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts. , opens new tabScreen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. © 2025 Reuters. All rights reserved Volume 9 - 2016 | https://doi.org/10.3389/fnmol.2016.00137 This article is part of the Research TopicMetabolic control of brain homeostasisView all 17 articles A correction has been applied to this article in: Corrigendum: Exogenous Ketone Supplements Reduce Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats Nutritional ketosis has been proven effective for seizure disorders and other neurological disorders The focus of this study was to determine the effects of ketone supplementation on anxiety-related behavior in Sprague-Dawley (SPD) and Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats We tested exogenous ketone supplements added to food and fed chronically for 83 days in SPD rats and administered sub-chronically for 7 days in both rat models by daily intragastric gavage bolus followed by assessment of anxiety measures on elevated plus maze (EPM) The groups included standard diet (SD) or SD + ketone supplementation Low-dose ketone ester (LKE; 1,3-butanediol-acetoacetate diester high dose ketone ester (HKE; ~25 g/kg/day beta-hydroxybutyrate-mineral salt (βHB-S; ~25 g/kg/day KS) and βHB-S + medium chain triglyceride (MCT; ~25 g/kg/day KSMCT) were used as ketone supplementation for chronic administration exogenous ketone supplements were also tested sub-chronically on SPD rats (KE KS and KSMCT; 5 g/kg/day) and on WAG/Rij rats (KE At the end of treatments behavioral data collection was conducted manually by a blinded observer and with a video-tracking system after which blood βHB and glucose levels were measured Ketone supplementation reduced anxiety on EPM as measured by less entries to closed arms (sub-chronic KE and KS: SPD rats and KSMCT: WAG/Rij rats) more time spent in open arms (sub-chronic KE: SPD and KSMCT: WAG/Rij rats; chronic KSMCT: SPD rats) more distance traveled in open arms (chronic KS and KSMCT: SPD rats) and by delayed latency to entrance to closed arms (chronic KSMCT: SPD rats) Our data indicates that chronic and sub-chronic ketone supplementation not only elevated blood βHB levels in both animal models We conclude that ketone supplementation may represent a promising anxiolytic strategy through a novel means of inducing nutritional ketosis Despite the proven and emerging therapeutic applications of the KD many patients experience difficulties with compliance or experience a loss of effectiveness over time; therefore EPM assay on SPD and WAG/Rij rats is a suitable method for investigate the effect of ketone supplementation-evoked changes on anxiety level the focus of this study was to test and determine the effects of several forms of ketone supplementation on anxiety-related behavior by using EPM behavioral assay in two rat strains Exogenous ketone supplements were fed chronically to SPD rats and administered sub-chronically (gavage bolus) to SPD rats and WAG/Rij rats prior to assessment of anxiety measures Two months old male SPD (n = 87) and 8 months old male WAG/Rij (n = 32) rats were used in the experiments The animals were housed at Department of Molecular Pharmacology and Physiology (Hyperbaric Biomedical Research Laboratory USA) and the Department of Zoology (University of West Hungary Animals were kept in groups of 2–4 under standard laboratory conditions (12:12 h light-dark cycle light was on from 08:00 AM to 08:00 PM) in air-conditioned rooms at 22 ± 2°C Animal treatment and measuring procedures were performed in accordance with the University of South Florida Institutional Animal Care and Use Committee (IACUC) guidelines (Protocol #0006R) and with the local ethical rules in accordance with the Hungarian Act of Animal Care and Experimentation (1998 Section 243/1998) in conformity with the regulations for animal experimentation in the European Communities Council Directive of 24 November 1986 (86/609/EEC) All experiments were approved by the University of South Florida IACUC and all efforts were made to reduce the number of animals used Ketone ester (KE; 1,3-butanediol-acetoacetate diester) was synthesized as previously described (D’Agostino et al., 2013) which is Na+/K +–β-hydroxybutyrate mineral salt) is a novel agent that was mixed into a 50% solution supplying approximately 375 mg/g of pure βHB and 125 mg/g of Na+/K+ in a 1:1 ratio Both KE and KS were developed and synthesized in collaboration with Savind Inc Human food grade medium chain triglyceride (MCT) oil (~60% caprylic triglyceride/40% capric triglyceride) was purchased from Now Foods (Bloomingdale KS was mixed with MCT in a 1:1 ratio (KSMCT) at the University of South Florida (USF In order to determine the effect of different administration forms when the ketone supplementation was mixed into the regular rodent chow which the animals had access to all day for several weeks and sub-chronic administration when the ketone supplementation was gavaged orally at a single time point daily for only 7 days A total of 48 male SPD rats were fed for 83 days with either standard rodent chow (2018 Teklad Global 18% Protein Rodent Diet (#2018) Harlan) standard diet (SD)/control; n = 9) or SD + ketone supplementation Four treatment animal groups included low-dose KE (~10 g/kg b.w./day KS; n = 9) and KSMCT (~25 g/kg b.w./day Higher dose was used for chronic administration as the rats were consuming food-integrated ketone supplementation throughout the day In order to familiarize the animals to the intragastric gavage method, water was gavaged for 5 days before ketone supplementation. Following the adaptation period to the intragastric gavage method, 39 male SPD rats were fed with standard diet, described in previous studies (Poff et al., 2013) and gavaged daily with 5 g/kg b.w./day water (SD/control; n = 11) or ketone supplements KE (n = 9) In addition, following the adaptation period to the intragastric gavage method, WAG/Rij male rats (n = 32) were fed with SD and gavaged sub-chronically with ~2.5 g/kg b.w./day water (SD/control; n = 8), KE (n = 8), KS (n = 8) or KSMCT (n = 8) for 7 days. For the sub-chronic gavage administration the gavage dose was used that induced desired elevation of blood ketone based on our previous studies (Kesl et al., 2016) EPM (Coulbourn Instruments) was used to assess anxiety-related behavior of the rats after 83 days of chronic feeding or after 7 days of oral gavage EPM experiments were carried out under non-stress conditions (in dimly lit and quiet room) between 12.00 h and 14.00 h The rats were transferred in their home cage to the experimental room 30 min prior to beginning the experiment rats were placed in the intersection of the four arms of the EPM facing the open arm opposite to where the experimenter was and their behavior was recorded for 5 min The amount of time spent and number of entries made on the open arms closed arms and the center zones were video recorded Latency to entry into the closed arms and the distance traveled in each zones was also measured in chronically treated SPD rats Only those behaviors are discussed at each experimental scenario where significant difference was found At the end of the 5 min test the rats were removed from the maze and placed back into their home cage The maze was cleaned with 70% alcohol and later with tap water and dried with paper towel between rats The primary method for data collection was a video-tracking system with computer interface and video camera (SMART V3.0 PLATFORM to automatically collect behavioral data in SPD rats A blinded observer was present in the testing room separated from the maze by a curtain and collected EPM data in both SPD and WAG/Rij animals blood βHB and glucose levels were measured 24 h before the 1st day of ketone treatments (baseline levels) and at 13th week after the EPM experiment blood βHB and glucose levels were measured 24 h before the 1st day of ketone treatments (baseline levels; SPD and WAG/Rij rats) 24 h after the first gavage and 60 min after gavage on the 7th day (SPD and WAG/Rij rats) Whole blood samples (10 μL) were taken from the saphenous vein for analysis of blood glucose (mg/dl) and βHB (mmol/l) levels with the commercially available glucose and ketone (βHB) monitoring system Precision XtraTM (Abbott Laboratories The body weight of all animals was recorded before the first ketone treatment (before) and on the last day of the ketone treatment (after) All data are presented as the mean ± standard error of the mean (SEM) We compared the effects of ketone supplementations on anxiety-related behavior as well as on blood βHB and glucose levels to control or/and baseline levels Data analysis was performed using GraphPad PRISM version 6.0a Results were considered significant when p < 0.05 Significance was determined by one-way analysis of variance (ANOVA) with Fisher’s LSD test for the behavioral data blood glucose and body weight change were compared using a two-way ANOVA with Tukey’s multiple comparisons test After chronic feeding of ketone supplementation in SPD rats the time spent in the open arms was significantly more in KSMCT group (p = 0.0094), while time spent in the closed arms was significantly less in LKE, KS and KSMCT groups (p = 0.0389, 0.0077 and 0.0019, respectively), compared to the control (SD) in SPD rats. Time spent in the center was significantly more in KS group (p = 0.0239; Figure 1A) Response of Sprague-Dawley (SPD) rats to chronic feeding of exogenous ketone supplementation (A) Rats consuming KSMCT supplements spent more time in open arms (open) KS and KSMCT groups spent less time in closed arms (closed) showing reduced anxiety compared to control (SD) group; (B) Rats consuming ketone supplements traveled more distance in open arms (KS and KSMCT) and less in closed arms (LKE showing reduced anxiety compared to control group; (C) Rats consuming KSMCT entered the closed arms later showing reduced anxiety compared to control group; (D) Rats consuming high dose ketone ester (HKE) KS and KSMCT showed elevated blood ketone levels after 13 weeks (after) compared to control group; (E) Blood glucose levels did not change significantly were lower in HKE and KSMCT groups compared to control after 13 weeks; and (F) body weight was lower in HKE group after 13 weeks compared to control standard rodent chow + water (~25 g/kg b.w SD + LKE (1,3-butanediol-acetoacetate diester SD + beta-hydroxybutyrate-mineral salt (βHB-S; ~25 g/kg b.w./day); KSMCT SD + βHB-S+medium chain triglyceride (MCT; ~25 g/kg b.w./day); (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001) Response of SPD rats to 7 days oral administration (gavage) of exogenous ketone supplementation (A) More time spent in open arms (open) by KE group and less time spent in center by KE KS and KSMCT groups were detected compared to control; (B) Less entries in closed arms (closed) by KE and KS groups; (C) Blood βHB levels were higher in KE group after 24 h and in KS and KSMCT groups after 7 days compared to control; (D) Blood glucose levels were lower in KE group after 24 h and in KSMCT group compared to baseline control and 24 h; (E) Body weight was lower in KE and KS groups compared to control after 7 days standard rodent chow + water (~5 g/kg b.w SD + ketone ester (1,3-butanediol-acetoacetate diester SD + beta-hydroxybutyrate-mineral salt (βHB-S; ~5 g/kg b.w./day); KSMCT SD + βHB-S + MCT (~5 g/kg b.w./day); (*p < 0.05; ***p < 0.001; ****p < 0.0001) Response of Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats to 7 days oral administration of exogenous ketone supplementation (A) More time spent in open arms (open) and less time spent in closed arms (closed) by KSMCT group were demonstrated compared to control; (B) Less entries in closed arms by KSMCT group and in open arms by KE group; (C) Blood βHB levels were higher in all treatment groups (KE (D) Blood glucose levels decreased after 24 h in KE group compared to control and baseline but increased after 7 days compared to 24 h in KE and KSMCT group; (E) Body weight did not change significantly in either groups standard rodent chow + water (~2.5 g/kg b.w SD + beta-hydroxybutyrate-mineral salt (βHB-S; ~2.5 g/kg b.w./day); KSMCT SD + beta-hydroxybutyrate-mineral salt (BHB-S) + MCT (KSMCT; ~2.5 g/kg b.w./day); (*p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001) Entries to the closed arms were less frequent with KE and KS treatment (p = 0.0436, 0.0234, respectively) in SPD and with KSMCT treatment (p = 0.0014) in WAG/Rij rat models, respectively, after 7 days of administration (Figures 2B, 3B). SPD rats also entered fewer times to the center when treated with KS (Figure 2A; p = 0.0193) WAG/Rij rats made less entries to open arms in KE treated group (p = 0.0318) After chronic feeding in SPD rats, the distance traveled in the open arms was significantly greater in KS and KSMCT groups (p = 0.036 and 0.0165), and distance traveled in the closed arms was significantly less in LKE, KS and KSMCT groups (p = 0.0252, 0.00041 and 0.0032), compared to the control (SD). Distance traveled in the center was more in KS and KSMCT groups (p = 0.0206 and 0.0482; Figure 1B) The latency to first entrance of closed arms was significantly greater in KSMCT group after chronic feeding (p = 0.0038; Figure 1C) After 83 days of chronic feeding in SPD rats, blood βHB levels remained significantly elevated in HKE, KS and KSMCT groups, compared to control (p = 0.0004, <0.0001, 0.0014; Figure 1D) while it decreased in SD compared to baseline (p = 0.0307) Blood βHB levels were elevated in SPD rats after 24 h of a single gavage in KE group (Figure 2C; p = 0.0325) After 13 weeks of chronic feeding in SPD rats blood glucose did not change significantly in any groups (Figure 1E) However, in SPD rats, after sub-chronic ketone treatments, blood glucose levels were lower at 24 h in KE group compared to control (p < 0.0001; Figure 2D). After 7 days of oral gavage blood glucose was lower in KSMCT compared to control, to baseline and to the level at 24 h in SPD rats (p < 0.0001; Figure 2D) In WAG/Rij rats the KE group had lower glucose levels after 24 h, compared to baseline levels (p = 0.0064), however after 7 days their level were elevated again, compared to the level at 24 h (p = 0.0006; Figure 3D). Moreover, glucose levels were also elevated after 7 days compared to 24 h in KSMCT group (Figure 3D) There was significant difference in βHB levels between the two animal models in KE and KSMCT groups at 7 days only (Figure 4A). The glucose levels were different between the two animal models in each treatment groups at each time points, except in KSMCT group at 7 days (Figure 4B) Blood βHB and glucose levels compared between the two animal models (A) Blood βHB levels were higher at 7 days in WAG/Rij rats after KE and KSMCT treatment (B) Blood glucose levels were significantly lower in WAG/Rij rats (**p < 0.01; ***p < 0.001; ****p < 0.0001) After chronic feeding, the body weight of SPD rats was lower in HKE group compared to the control (p = 0.0366). The body weight increased in SD and KSMCT groups, compared to their baseline (p = 0.0015, 0.0012; Figure 1F) After 7 days of treatment the body weight of SPD rats increased in SD group, compared to its baseline (p = 0.0297). The body weight was lower in KE and KS treatment groups after 7 days, compared to control (p = 0.0005, <0.0001; Figure 2E). In WAG/Rij rats the body weight did not change significantly in either group during the treatment period (Figure 3E) The current study demonstrated the anxiolytic effect of chronic (13 weeks) and sub-chronic (7 days) administration of several forms of ketone supplementation in both SPD and WAG/Rij rats Anxiolytic effect was assessed by means of EPM and measured by less entries and time spent in closed arms and delayed latency to entrance into closed arms Since many of the benefits of ketosis are mechanistically attributable to the ketone bodies it is possible that exogenous ketone supplementation could mimic the therapeutic efficacy of the KD for certain disorders such as seizure disorders and AD that have a comorbidity of anxiety The differences in blood βHB and glucose levels between the two animal models both before and after the treatment highlight the need to examine the response to ketone supplementation in more rodent models with different pathologies Both in chronic and sub-chronic KE treatment resulted in lower body weight in SPD animals the body weight did not change significantly during the treatment period in WAG/Rij rats the exogenous ketone supplementation tested in the present study similarly increased the open arms exploration in the EPM and increased the latency to enter the closed arms LKE decreased time spent in closed arms and reduced distance traveled in closed arms after chronic treatment decreased time spent in center and decreased number of entries in closed arms after sub-chronic treatment in SPD rats KS was proven to be effective in reducing time spent and distance traveled in closed arms and increase distance traveled in open arms after chronic treatment It also reduced time spent and number of entries to center while decreasing number of entries in closed arms after sub-chronic treatment in SPD rats KSMCT effectively increased time spent and distance traveled in open arms and decreased time spent and distance traveled in closed arms as well as delayed latency to first entrance to closed arms after chronic treatment in SPD rats In WAG/Rij rats KSMCT successfully increased time spent in open arms and decreased time spent and number of entries in closed arms after sub-chronic treatment Differences could be observed between the effects of different ketone supplements on anxiety These results indicate that KS and KSMCT are the most effective after chronic treatment while KE and KS seem to be the most effective after sub-chronic treatment in rats without pathology (SPD) In rats with pathology (WAG/Rij) KSMCT was the most effective treatment after sub-chronic administration our results on WAG/Rij rats strengthened the hypothesis on anxiolytic effect of exogenous ketone supplementation found in SPD rats our knowledge is not sufficient at present to explain the mechanism(s) by which ketone supplementation exerts its anti-anxiety effects we can conclude that chronic and sub-chronic administration of exogenous ketone supplementation may be an effective way to reduce anxiety Achieving nutritional ketosis with exogenous ketone supplementation while maintaining a normal diet might be an alternative to the KD or may further augment the therapeutic efficacy of the KD it is important to understand the long-term effects of these supplements fed chronically These preliminary data show that chronic and sub-chronic feeding of ketone supplements not only elevated blood ketone levels which can be highly beneficial for patients managing diseases like epilepsy and AD with nutritional ketosis Since achieving nutritional ketosis requires strict dietary restrictions compliance is a major difficulty in this treatment The administration of exogenous ketone supplements that increase ketone levels in the blood without dietary restrictions may be an effective option to improve compliance We propose that exogenous ketone supplementation could provide an alternative method to reduce anxiety for healthy individuals as well as those with disorders that are metabolically managed with the KD further studies are needed to determine the molecular basis of ketone supplementation-induced anxiolytic changes and how this strategy can be implemented in human clinical trials with patients suffering anxiety disorders writing manuscript; ZK: design of experiments revising manuscript; CM and CRG: data collection; GJ and DPD: design of experiments International Patent # PCT/US2014/031237 “Compositions and Methods for Producing Elevated and Sustained Ketosis” Arnold (Savind) has received financial support (ONR N000140610105 and N000140910244) from D.P D’Agostino (USF) to synthesize ketone esters D’Agostino “Exogenous Ketone Supplements for Reducing Anxiety-Related Behavior” The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest The reviewer DR and handling Editor declared their shared affiliation and the handling Editor states that the process nevertheless met the standards of a fair and objective review This work was supported by Office of Naval Research (ONR) Grant N000141310062 (to DPD) the National Development Agency of Hungary (under Grant No the National Development Agency of Hungary TÁMOP 4.2.1./B-09/1/KMR-2010-0003 and the KTIA_NAP_13-2014-0023 (to GJ) We wish to thank Tamás Török (NYME SEK) for the technical assistance Glucose transporter type-1 deficiency syndrome; HKE Phobic anxiety and risk of coronary heart disease and sudden cardiac death among women Google Scholar Anticonvulsant mechanisms of the ketogenic diet Potential of ketone body esters for parenteral and oral nutrition Ketone ester supplementation attenuates seizure activity and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model Model of extreme hypoglycemia in dogs made ketotic with (R,S)- 1,3-butanediol acetoacetate esters safety and tolerability of 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Anxiety-Related Behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk Rats Received: 15 September 2016; Accepted: 22 November 2016; Published: 06 December 2016 Copyright © 2016 Ari, Kovács, Juhasz, Murdun, Goldhagen, Koutnik, Poff, Kesl and D’Agostino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution and reproduction in other forums is permitted provided the original author(s) or licensor are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Csilla Ari, Y2RyYXJpQGhlYWx0aC51c2YuZWR1; Y3NhcmkyMDAwQHlhaG9vLmNvbQ== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Essential digital access to quality FT journalism on any device Complete digital access to quality FT journalism with expert analysis from industry leaders Complete digital access to quality analysis and expert insights complemented with our award-winning Weekend Print edition Terms & Conditions apply Discover all the plans currently available in your country See why over a million readers pay to read the Financial Times “If you don’t include the subsur­face in the journey towards reducing CO2 emissions, it will be impossible to reach net zero”, says Frank van Bergen. Frank heads up the Rijswijk Centre for Sustainable Geo-energy (RCSG) where a broad range of fa­cilities enable the testing of subsur­face drilling technology for the ener­gy transition “We know that drilling for geo­thermal energy production or stor­ing CO2 in the subsurface requires a vastly different approach to mate­rial selection and technology” we also know that re­newables are more cash-constrained than oil and gas This means that innovation in drilling technology is required to bring down these costs whilst main­taining high-spec material proper­ties at the same time “That is what we aim to do here in Rijswijk” “We play a facilitatory role in the development of new technology such that the full-scale implementa­tion in the field runs as smoothly as possible new technol­ogy can be tested at downhole condi­tions and at a 1:1 scale.” Dutch start-up Canopus developed a new drilling technology that bombards the formation with a continuous flow of small steel particles through a nozzle thereby weakening the rock before the bit removes it Prior to testing this technology in Switzerland the RCSG facilitated a range of experiments whereby the initial design could be fine-tuned The company is now embarking on experiments using a larger bit and tests have already shown that conventional ROPs can be beaten by a factor of 2.5 “When Shell decided it was time for another player to continue manag­ing this extensive oil and gas drilling test facility we saw it as an oppor­tunity to give it another lease of life with the energy transition in mind” “we target the higher TRL levels of product maturation just before piloting the new solution in the field Performing tests in a fully controlled environment may point out issues that might either jeopard­ize field implementation or severely delay it.” downhole tools and other equip­ment and expose the material to dif­ferent pressure and fluid regimes We have a 380 m deep borehole that can serve as a real subsurface laboratory in which we can test the performance of tools and materials that are used for drilling by replicating the conditions as closely as possible Let’s now look at a few examples of studies the RCSG has recently been involved with further demonstrating the niche position of the facility We offer a fully scaled environment for testing conditions such as found in the subsurface One of the differences between oil and gas wells and CO2 injection wells is the cyclicity in bottom-hole tem­peratures Where oil and gas wells do not tend to experience large temper­ature variations at depth this is very different in CO2 injection projects in depleted gas fields where super-criti­cal CO2 expands as soon as it hits the formation This could in theory have a detrimental effect on the integrity of the cement between the casing and the bedrock potentially leading to micro-fractures and the risk of CO2 migrating upwards through the an­nuli Geothermal wells can experi­ence similar thermal stress Whether this damage actually occurs can be tested under controlled conditions in the lab “The effect of these tem­perature changes on the integrity of wellbore cement can be simulated in the RSCG lab at representative bot­tom-hole temperatures” “We are running a project along these lines at the moment.” The drilling of shallow geothermal closed loops has seen a dramatic in­crease over the past few years in re­sponse to rocketing gas prices and government incentives to decouple domestic heating from the gas grid The depth limits of these closed loops are now shifting from a “convention­al” 200 m to being closer to 500 m all with the drive to extract more en­ergy and potentially provide blocks of houses with baseload energy instead of having one loop per house The boreholes drilled for these loops are filled with grout “We are now looking at how these grout mixtures behave when exposed to higher pressures and potentially larger temperature variations” due to extraction of energy from the circulating fluids by the heat pump temperatures in the borehole can drop close to freezing We are currently running a project that monitors per­meability changes of the grout under those circumstances which will en­able us to provide recommendations with regards to the best cement-clay mixture.” In the Netherlands and many other sedimentary basins across the world there is an increasing interest in explor­ing reservoir sands at relatively shallow depths (800 – 1,500 m) for open-loop geothermal systems that can be direct­ly used for low-temperature heat grids or as input for heat pumps The clear advantage of tapping into reservoirs at this depth range is the likelihood of finding much bet­ter reservoir quality than when going deeper which also takes away an im­portant risk element in these projects lower formation water temperatures in the region of 30-50° C are commonly encountered higher extraction rates are often required in order to produce similar amounts of energy compared to the deeper systems Another clear example of the critical role the facility played in the development of new technology is the work performed to test the role of bentonite as an agent to abandon wells rather than using cement This originated as an idea but led to a full-scale testing project at the RCSG that ultimately culminated in a pilot in an existing oil and gas well “The point where we are now — technical readiness for commercial deployment — would not have existed without the role the RCSG played in the process” Groundwater drillers are not allowed to drill beyond depths of 500 m be­cause they don’t have the right safety measures in place whilst an oil / gas rig is too expensive to use for holes of this kind We are looking at ways to make it possible to have the best of both options – the agility and af­fordable running costs of groundwater drilling rigs and the safety features of more powerful oil and gas drilling in­stallations.” If you don’t de-risk new technology properly in the lab full-scale field implementation can be a very costly and frustrating exercise we are looking at ways to optimize circulation in horizontal wells that are to be drilled in these poorly consolidated sands Circulat­ing too much may lead to wash-outs but circulating too little leaves the cuttings in the hole There is a nar­row operational window here” “and we clearly need to test this to find out what the best opera­tional procedure is.” After five years of getting projects and technologies closer to maturation it can be concluded that the RCSG has cemented its role in the development and demonstration arena “We are here to help the implementation of subsurface projects in the energy tran­sition One thing that we are now par­ticularly keen on” “is to start collaborating more with oil and gas companies that are looking to branch out into the geothermal or the subsurface storage space and how our center can be used as part of the pro­cess that is often required to progress drilling technology towards successful implementation in the field We wel­come any companies interested in this to get in touch with us.” Henk KombrinkHenk.Kombrink@geoexpro.com+44 77 8899 2374 Sales DirectorIngvild Ryggen CarstensSales Enquiries+47 974 69 090 a well-known Carleton Place and Renfrew businessperson and community leader The tradition of a free community Christmas dinner in Carleton Place continued in 2020 with Mark Van Rijswijk (right) taking over the reins after Kory Earle stepped aside after 13 years following the sudden death of co-owner Mark Van Rijswijk A Carleton Place and Renfrew businessperson He is being remembered as a devoted family man a faithful friend and a community-minded guy Van Rijswijk co-owned The Waterfront Gastropub Final Score Sports Bar and Trailside Canteen in Carleton Place and Final Score Sports Bar in Renfrew he co-owned two establishments in Sudbury: Shaughnessy’s Pub and Grill and Envy Tapas & Lounge “It was sad to hear of Mark’s passing,” Carleton Place Mayor Toby Randell told Inside Ottawa Valley “As an owner of multiple well-known businesses in Carleton Place he was someone who touched many people’s lives on a regular basis.” He added: “Although I did not know him personally and I send them and his family my condolences and sincere sympathies.” Van Rijswijk is being remembered as a devoted family man John and Lisa Bailey were business partners with Van Rijswijk and Dunn John wrote: “Today has been one of the hardest of my life as we lost not only our very close friend and our business partner but an absolute legend who would do anything for everyone.” “I have learned so much from you and thank you for the opportunity to be your friend and to be part of the business,” he continued “I will try to honour you in everything we do.” with Van Rijswijk taking over the reins after Kory Earle stepped aside after 13 years Christmas can be difficult for many people — those living alone those struggling to make ends meet or those who find themselves far away from family and friends this event will impact so many in need … at a time when people are finding things so difficult,” Van Rijswijk expressed at the time “I will always give back to my community.” who has known Van Rijswijk for several years was “deeply shocked and saddened by the loss of Mark.” “He has given so much to Carleton Place and I was truly grateful when he took over the free community Christmas dinner,” Earle stated hundreds of people have received a free hot meal and some festive cheer on Dec When asked in June what was next for the group Van Rijswijk responded: “We are going to try to slow down for a little bit and enjoy what we have built I think we are going to take a breather for at least a year.” Acknowledging that many businesses did not survive the COVID-19 pandemic Van Rijswijk called himself and his partners “very fortunate.” “We do not take anything for granted,” he emphasized Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Invalid password or account does not exist Submitting this form below will send a message to your email with a link to change your password An email message containing instructions on how to reset your password has been sent to the email address listed on your account Tonella’s leadership is expected to drive ING’s digital transformation ING has announced the appointment of Daniele Tonella as Chief Technology Officer (CTO) and member of the Management Board Banking who has held the role ad interim since November 1 in addition to his responsibilities as Chief Operations Officer and Chief Transformation Officer Daniele Tonella brings over 20 years of experience in technology leadership within the financial industry His impressive career includes pivotal roles at UniCredit where he served as Group Chief Information Officer and CEO of UniCredit Services from 2017 to 2021 he held various significant positions at AXA Group Tonella’s career began as a consultant at Mercer and McKinsey & Company in Switzerland providing him with a robust foundation in industrial engineering and strategic consulting Tonella’s academic credentials are equally noteworthy He holds a master’s degree in industrial engineering from the Eidgenssische Technische Hochschule Zürich in Switzerland and has completed executive education programs at prestigious institutions such as Harvard Steven van Rijswijk, CEO of ING expressed his confidence in Tonella’s ability to drive the bank’s digital strategy forward ” Daniele’s experience and track record in digital leadership will greatly benefit ING in executing our strategy to be the best European bank and delivering value,” van Rijswijk stated He also extended his gratitude to Marnix van Stiphout for his interim leadership and the CTO management team for their support in delivering on ING’s tech priorities Tonella himself is enthusiastic about his new role “ING is a bank with a purpose that pushes the boundaries of what engineering in banking can be and of what technology in banking can do I am proud to become part of this team that looks beyond the horizon and gets there.” The appointment of Daniele Tonella has been approved by the European Central Bank marking a significant milestone in ING’s journey towards digital excellence With Tonella at the helm of technology, ING aims to enhance its digital capabilities, ensuring the bank remains at the forefront of innovation in the banking industry UK banks unite with NCA to tackle financial crime Paysafe and Alchemy Pay team up to boost crypto payments Discover the impact of the Saiber and Salmon Software alliance in the Middle East and treasury management is revolutionizing fintech The energy transition is a global challenge and an opportunity for energy companies The opportunities for energy applications are endless Tap into the latest innovations and transform existing ideas with the TNO RCSG-lab to technologies that can build a robust business case for sustainable energy projects New applications need technologies beyond the current toolset particularly considering the anticipated growth of sustainable energy production Effective maturation of these new technologies is one of the main challenges as you cannot demonstrate innovations directly in a commercial environment Accelerating this pathway is therefore vital to bring these technologies to market The opportunities for energy applications are endless. Meet our latest technological innovations with TNO's open test centre for sustainable geo-energy in this video Our TNO Rijswijk Centre for Sustainable Geo-energy (RCSG) in the Netherlands is a unique open innovation lab for improving geo-energy technologies We focus on developing technologies for geothermal Our facilities are available for large-scale testing and demonstration of new innovative drilling techniques and material improvements under high pressure and temperature We can mimic relevant subsurface conditions to study the behaviour of materials and tools under these conditions (elevated temperature We develop and mature technological innovations for wells before they are fielded and marketed reducing the financial risk of field testing and thereby maximising business opportunities for the technology at hand With our research focus and applications at RCSG we cover the complete tech-ready maturation process Walk through the TNO Rijswijk Centre for Sustainable Geo-energy (RCSG) in the virtual tour and see the facilities With more than 1,100 colleagues working on the energy transition and over 100 years in subsurface expertise TNO contributes to the interconnected relationship between energy and society and an affordable and sustainable energy system Our deep understanding of the subsurface and energy transition guides the way materials and system integration enable governments and businesses to make informed decisions We activate our network of public and private partners throughout Europe to bring new and impactful technologies to life Want to know more about advanced drilling technology Gain insights into two advanced technology developments and their pathways to market Learn how innovative drilling technologies can drive the heat transition forward We see new markets and opportunities to sustainable geo-energy By developing innovative drilling technologies we are driving down costs and making sustainable energy projects more viable for companies Our full-scale experiments examine the interaction between wells and the surrounding rocks we are exploring new materials for well sealing like cement and grout testing under realistic conditions we are investigating options to reuse existing infrastructure turning old gas wells into geothermal sources or CO2 storage sites With advanced sensors and data acquisition tools guaranteeing safety and optimising performance we are taking concrete steps toward a greener future making the energy transition not just possible but practical and sustainable cost-effective geothermal production using advanced directional drilling technology the largest independent R&D organization of the Netherlands RCSG cooperates with multiple partners from industry and academia to develop and mature well technology innovations before application in the field TNO collaborates with companies to test new geo-energy technologies in a controlled lab environment accelerating innovation and market introduction We invite you to innovate with us and explore business opportunities within the growing energy demand and are happy to design and develop future sustainable solutions with you My focus is on developing projects in well technology to improve access and utilization of the subsurface I have spent many years promoting and developing drilling technology in the energy sector and I am excited to leverage this experience to make an impact with TNO in this important area of subsurface utilization We chat with debut author Honni van Rijswijk about her debut novel Breeder which is a new YA sci-fi novel from Blackstone Publishing I’m an academic in a law school—I used to be a lawyer—and I also write novels I love genre fiction and TV/films—everything from crime mysteries to horror/thriller I’m looking forward to life opening up more in the second half of 2021 a visiting nun ran an amazing workshop for us where she broke down the steps of drafting editing and revising a story for publication revise and “publish” one story a week for several weeks who lives in a brutal world that provides no clear or easy options BREEDER really digs into the gray area of morality hopefully it gives you a chance to think through what you would do in extreme situations The book goes to some dark places (as well as many light/funny moments) but it took a while for me to be comfortable “going there” and staying there and feeling confident that this sometimes bleak story would resonate with people I came back to the idea that it’s the book I would have wanted to read at 15 Will just wants to be normal and to get a good job find a girlfriend and eventually have a kid—even though these things are basically impossible in Will’s world Will’s stubborn desire to not have their world disturbed resonated with me even in the face of literal world collapse and a band of comrades trying to push Will to revolution I really enjoy inhabiting moral grey areas in fiction I always go back to this when I’m lost or stuck See alsoQ&A: Megan Lally, Author of ‘No Place Left To Hide’ Worst: fiction should be literary fiction, “genre” fiction is beneath real writers. Most of my favorite books are genre books, and some extreme human experiences need the excesses of genre to make sense. The best novel about law, history and trauma is Toni Morrison’s Beloved, which is also a horror story, because you usually need to go beyond realism to capture the experience of trauma. A literary crime/suspense novel (adult) and a ghost story about gender violence (YA) Looking forward to receiving my copy which I hope Honni will sign for me. No pressure Honni just when you get out of lockdown and are able to visit. Can’t wait to read this book. It seems awesome! Zeen is a next generation WordPress theme. It’s powerful, beautifully designed and comes with everything you need to engage your visitors and increase conversions. The Public Prosecution Service (OM) in The Hague said a 57-year-old man currently in custody for the deadly shooting of a woman in Rijswijk is also suspected of four additional counts of attempted manslaughter. The woman’s 4-year-old child was at the scene at the time of the shooting on Friday evening. The man in custody is suspected of murdering the 38-year-old woman. The alleged gunman is also accused of trying to kill the boy, and three other local residents, the OM said Monday. She was shot around 5:45 p.m. in the entryway of an apartment building on Galjoenstraat. The woman died at the scene. The suspect, reportedly a neighbor, was still in the building at the time and was immediately arrested by the police. He appeared before a magistrate on Monday and was remanded into custody for at least 14 more days. The child was "in the immediate vicinity of his mother when shots were fired," according to the Public Prosecution Service. The OM is not yet sharing how the three residents were involved in the incident. A spokeswoman says that "in the interest of the investigation, this is all we can share at this time." According to broadcaster Omroep West, the victim’s son witnessed the shooting. The outlet also reported that the suspect is believed to be the victim’s neighbor, according to area residents. The municipality of Rijswijk organized a community meeting about the murder on Monday evening. Mayor Huri Sahin called the incident a "horrifying tragedy" which "has had a tremendous impact on the Rijswijk community." She also noted that "another murder of women" seems to have taken place in her municipality, alluding to other cases of femicide where a woman was killed by either a current or former relation, or someone pursuing them. Last year in June and November, two women were killed in Rijswijk by their partners. “Together with the police and the housing corporation Rijswijk Wonen, I spoke with several local residents. The tragedy that unfolded yesterday has left everyone deeply shocked,” Sahin previously said on Friday. Police are still investigating the case and seeking witnesses. People who saw the shooting are encouraged to seek out emotional support from the service Slachtofferhulp. 2024 Photo: DepositphotosOne person has died and two people were treated for smoke inhalation in a fire at an apartment block in Rijswijk on Tuesday Fire services were called to the ground floor flat in the Louis Davidsstraat at around 5pm, local broadcaster Omroep West reported The six-storey building had to be evacuated temporarily because of thick smoke and one person on the third floor had to be rescued by the fire brigade using an aerial ladder Police are investigating if the person who died in the fire lived at the address An investigation into the cause is ongoing We could not provide the Dutch News service without the generous support of our readers Your donations allow us to report on issues you tell us matter and provide you with a summary of the most important Dutch news each day Many thanks to everyone who has donated to DutchNews.nl in recent days We could not provide this service without you Please help us making DutchNews.nl a better read by taking part in a short survey Two suspects were arrested for two separate suspicious deaths in Rijswijk and Schagen on Monday A suspect in the same street was arrested later that evening Nothing has been shared about the suspect’s identity in this case This came a day after a body was found in Schagen Police were called to a home on the Scholeksterlaan in Schagen at around noon on Sunday afternoon The caller stated that a man had become unwell Emergency services tried to resuscitate the man at the scene This led to the police starting an investigation into the death and arresting a 35-year-old man from Schagen which means that he is only allowed to have contact with his lawyer His role in the death is being investigated One person was assaulted during an attempted kidnapping in Delft on Thursday night Two people connected with the case were arrested overnight and a third person of interest was still being sought on Friday afternoon The victim was assaulted by occupants of a "suspicious black van" during the kidnapping attempt He was identified as a 41-year-old from Rotterdam The man was treated for his injuries in the hospital on Reinier de Graafweg in front of a hospital in the city's Buitenhof district the police in Rijswijk were able to make two arrests in connection with this incident," police said on Friday the police are still looking for another possible suspect." Authorities asked anyone who may have seen the van parked or driving in the area to contact them those who were in Delft and Rijswijk were asked to get in touch with police if they saw the van Anyone with camera footage from the area should contact detectives please click the box below to let us know you're not a robot Get the most important global markets news at your fingertips with a Bloomberg.com subscription Surrounded by century-old fruit trees on a historic property outside Den Hague, Netherlands, Barn Rijswijk is a stunning example of how good, informative design can completely transform and otherwise ordinary structure into something, well, worth writing about. Designed by young Amsterdam-based firm Workshop Architecten the contemporary barn is both respectful of the area’s archetypal architecture and aware of the future world it will exist in for decades to come We’re especially loving the areas of transparency both literal doorways offering ample access to storage areas but also the generous use of translucent roofing and windows The natural light and untreated wood interior contrasts nicely with a facade clad in black-stained Douglas Fir wood visit Workshop Architecten directly for more on this project and others Volume 14 - 2020 | https://doi.org/10.3389/fnins.2020.618422 the elevation of blood ketone levels with ketogenic diets (KDs) has beneficial effects while exogenous ketone supplements (EKSs) were shown to increase the level of blood ketone bodies (such as β-hydroxybutyrate βHB) and decrease blood glucose levels without dietary restrictions It has been suggested that ketone body and glucose utilization of the body may be modified by age and gender resulting in changes in blood βHB and glucose levels but it was not investigated through several months yet we investigated whether the effect of an EKS on blood βHB and glucose level is modulated by age and sex in Wistar Albino Glaxo Rijswijk (WAG/Rij) rats We used KEMCT (1:1 mix of ketone ester/KE and medium-chain triglyceride/MCT oil) by oral gavage in female and male WAG/Rij rats which was supplemented by KEMCT (2.5 g/kg) once per month by oral gavage for 17 months changes in blood R-beta-hydroxybutyrate (R-βHB) and glucose levels were measured KEMCT gavage significantly increased blood R-βHB and decreased blood glucose levels the KEMCT-induced increase in blood R-βHB levels was lower at the 7th and 8th months and higher at the 16th and 17th months compared with the results at the 1st month KEMCT-generated increase in R-βHB levels was higher in female rats compared with male rats between the 2nd and 11th months but older (between the 14th and 17th months) female rats showed lower levels than males KEMCT gavage induced significantly lower glucose levels at the 4th only males showed significantly lower levels KEMCT treatment induced lower blood glucose levels in female than in male rats between the 1st and 8th months but higher glucose levels were measured in female rats at the 17th month than in males These findings suggest that age and sex can modify the EKS-evoked effects on blood R-βHB and glucose concentrations These results lead to the crucial question of whether age and sex can modulate EKS-evoked changes in not only blood βHB but also glucose levels Animal treatments were carried out according to the Hungarian Act of Animal Care and Experimentation (1998 European Communities Council Directive 24 November 1986 (86/609/EEC) and EU Directive 2010/63/EU to use and treat animals in experimental laboratories Experiments were approved by the Animal Care and Experimentation Committee of the Eötvös Loránd University (Savaria University Centre) and the National Scientific Ethical Committee on Animal Experimentation (Hungary) under license number VA/ÉBNTF02/85-8/2016 Male (n = 8) and female (n = 8) WAG/Rij rats (breeding colony of WAG/Rij rats at Eötvös Loránd University Hungary) were kept in groups of three to four after weaning (on the 25th day) under standard laboratory conditions (12:12 h light–dark cycle to 08:00 p.m.; free access to standard rodent chow diet and water; air-conditioned room at 22 ± 2°C) All efforts were made to minimize pain and suffering and to reduce the number of animals used Ketone ester (1,3-butanediol acetoacetate diester) was developed by D’Agostino et al. (2013) (University of South Florida/USF United States) in collaboration with Savind whereas MCT oil (pharmaceutical grade; approximately 60% caprylic triglyceride and 40% capric triglyceride) was purchased from Now Foods (Bloomingdale We demonstrated previously that intragastric gavage of not only KE and MCT oil but also KEMCT (mix of KE and MCT oil in a 1:1 ratio; ad libitum access to normal rat chow + 2.5g/kg body weight KEMCT) effectively induced and maintained ketosis without causing side effects (Ari et al., 2016; Kesl et al., 2016; Kovács et al., 2020) 2.5 g/kg dosage of KEMCT was administered once a month by intragastric gavage for 17 months To familiarize the animals to the gavage method all KEMCT gavage treatments were preceded by water gavage (2.5 g/kg) for 4 days (adaptation period) Levels of blood βHB and glucose were measured 1 h after gavage (between gavage and βHB/glucose measurements the animals had free access to food and water) Control βHB and glucose levels were measured on the last (4th) day of the adaptation period as well as measurements of KEMCT-induced changes in blood βHB and glucose levels the experiments were started on 1-month-old rats A similar protocol was repeated once every month for 17 months Each rat was euthanized with isoflurane after the last data collection Similar to our previous studies (Kovács et al., 2018, 2020) blood was taken from the tail vein of rats about 60 min after the gavage and βHB and glucose levels were measured by a commercially available glucose and ketone monitoring system (Precision XtraTM This instrument only measures blood levels of R-βHB total blood ketone levels (R-βHB + S-βHB + AcAc + acetone) would be higher than we measured Body weights of rats were also measured every month 1 day before the adaptation period Pearson correlation was calculated for KEMCT treatment-induced changes in blood βHB and glucose levels Results were considered significant when p < 0.05 Mix of KE and MCT gavage significantly increased blood R-βHB levels in both female (Figure 1A) and male (Figure 1B) WAG/Rij rats every month there was a trend of increased R-βHB levels KEMCT-evoked changes in blood R-βHB and glucose levels in female and male WAG/Rij rats once per month) significantly elevated the blood R-βHB levels (A,B) and decreased blood glucose levels (C,D) compared with the control in both female and male rats mix of ketone ester (KE) and medium-chain triglyceride (MCT) oil in a 1:1 ratio *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001 A significant decrease in blood glucose levels was demonstrated after KEMCT gavage, compared with the control every month in both sexes, except at the 5th and 13th months of male rats (Figures 1C,D) Effect of age and sex on KEMCT-evoked changes in blood R-βHB levels Sex-dependent alterations in blood R-βHB levels The control level of blood R-βHB levels was similar in both sexes (A) KEMCT-induced increase in R-βHB levels (B) and differences between KEMCT-evoked R-βHB levels and control R-βHB levels (C) were significantly different in female rats compared with male rats mix of ketone ester (KE) and medium-chain triglyceride (MCT) oil in a 1:1 ratio; R-βHB Effect of age and sex on KEMCT-evoked changes in blood glucose levels Sex-dependent changes in blood glucose levels Control glucose levels were different (lower) in male rats compared with female rats only at the 16th and 17th months (A) KEMCT treatment-generated blood glucose levels were significantly lower in female than male rats at the 1st Differences between KEMCT-evoked glucose levels and control glucose levels did not show significant alterations between sexes (C) *p < 0.05; **p < 0.01; ****p < 0.0001 Effect of age and sex on body weight of WAG/Rij rats Body weight of female and male WAG/Rij rats Body weight of male rats was significantly higher than the body weight of female rats ***p < 0.001; ****p < 0.0001 we demonstrated first by a long-term (17 months) study that the EKS KEMCT-generated changes in blood R-βHB and glucose levels can be modulated by age and sex These results suggest that likely there is no relationship between differences in body weight of female and male animals and alterations in not only the control but also KEMCT-evoked changes in blood R-βHB and glucose levels the influence of body weight differences between sexes on KEMCT-generated effects cannot be ruled out entirely more studies are needed to find the exact links between the KEMCT-evoked changes in blood R-βHB and glucose levels and changes in the activity of metabolic enzymes and transporters of different organs during aging (as putative background of KEMCT-generated effects) in animals with different ages and in both sexes these results suggest that different doses of EKSs may be needed for safe and effective treatment of different age groups and in both genders suggests the potential of these compounds to enhance quality of life and for the treatment of different neurometabolic and age-related diseases The present study suggests that the EKS-evoked effects on blood R-βHB and glucose levels may be modulated by both age and sex the age- and gender-dependent modulatory effects of EKSs on blood R-βHB (ketosis) and glucose concentrations should be taken into consideration during the administration of metabolic-based therapies for the treatment of different diseases monitoring of blood ketone body and glucose levels of EKS users may be important in order to find safe and effective doses of EKSs for different age groups and in both genders further studies are needed to reveal the exact mechanism(s) of action of ketone body and glucose production (metabolism) and utilization during aging and the potential gender-evoked modulatory processes on EKS-induced blood βHB and glucose levels not only in animals but also in human subjects The raw data supporting the conclusions of this article will be made available by the authors The animal study was reviewed and approved by the Hungarian Act of Animal Care and Experimentation BB contributed to the acquisition of the data CA analyzed the data and wrote the manuscript All authors read and approved the final manuscript This work was supported by the National Development Agency of Hungary (under Grant No OTKA K124558 Research Grant (to ZK) and ONR Grant N000141310062 (to DD’A) The funding body had no influence on the design of the study University of South Florida for DD’A: “Compositions and Methods for Producing Elevated and Sustained Ketosis” DD’A and CA are co-owners of the company Ketone Technologies LLC a company specialized on scientific research All authors declare that there are no additional conflicts of interest medium-chain triglyceride oil; R- β HB β-Hydroxybutyrate in the brain: one molecule The effects of a ketogenic diet on behavioral outcome after controlled cortical impact injury in the juvenile and adult rat Exogenous ketone supplements reduce anxiety-related behavior in Sprague-Dawley and Wistar Albino Glaxo/Rijswijk rats Google Scholar Nutritional ketosis delays the onset of isoflurane induced anesthesia Exogenous ketone supplements improved motor performance in preclinical rodent models Exogenous ketones lower blood glucose level in rested and exercised rodent models A multicenter randomized controlled trial of effect of medium-chain triglyceride dietary supplementation on epilepsy in dogs Quantitative histochemical changes in enzymes involved in energy metabolism in the rat brain during postnatal development Glucose-6-phosphate dehydrogenase and beta-hydroxybutyrate dehydrogenase Seizure resistance is dependent upon age and calorie restriction in rats fed a ketogenic diet CrossRef Full Text | Google Scholar Ketogenic diets: from cancer to mitochondrial diseases and beyond The effect of adenosine and chloroadenosine on sex differences in the energy metabolism of rat hepatocytes Sex hormones regulate rat hepatic monocarboxylate transporter expression and membrane 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the cellular perspective Pharmacoresistant epilepsy: a current update on non-conventional pharmacological and non-pharmacological interventions On the metabolism of exogenous ketones in humans Metabolic fate of 1,3-butanediol in the rat: conversion to -hydroxybutyrate Glucagon and vasopressin V1a receptor signaling in hepatocytes from aging rats Sex-specific regionality of liver metabolism during starvation; with special reference to the heterogeneity of the lobular periphery Developmental expression of GLUT1 and GLUT3 glucose transporters in rat brain Activities of enzymes involved in acetoacetate utilization in adult mammalian tissues The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease D’Agostino DP and Ari C (2021) Age- and Sex-Dependent Modulation of Exogenous Ketone Supplement-Evoked Effects on Blood Glucose and Ketone Body Levels in Wistar Albino Glaxo Rijswijk Rats Copyright © 2021 Kovács, Brunner, D’Agostino and Ari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited *Correspondence: Csilla Ari, Y3NhcmkyMDAwQHlhaG9vLmNvbQ== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish. Steven van Rijswijk has been a member of the Executive Board since 8 May 2017. He has been Chief Executive Officer (CEO) and chairman of this Board since 1 July 2020. Prior to his appointment as CEO and chairman of this Board, he was the Chief Risk Officer (CRO). He is also chairman of the Management Board Banking. Steven is also member of the Management Board of the Nederlandse Vereniging van Banken (NVB). He holds a master’s degree in business economics from Erasmus University Rotterdam, the Netherlands. Text description provided by the architects the client wanted to replace a neglected sixties barn by a contemporary design The new barn fits to both the landscape and the historical buildings on the estate where the main building is the monumental farm ‘Rottenburg’ the new barn also accommodates an apartment The main structure consists of four timber slabs that divide the barn into three zones: a barn area a semi-transparent intermediate zone and an apartment Openings in the slabs offer a view from the apartment in the yard and the old orchard The semi-transparent intermediate zone connects the south-west side with the north-east side of the farmyard The facade consists of black-stained Douglas which contrasts with the raw wood on the inside You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Digital access for organisations. Includes exclusive features and content. See why over a million readers pay to read the Financial Times. ING, the largest Dutch bank, said on Friday that chief risk officer Steven van Rijswijk would replace Ralph Hamers as the chief executive officer from July 1st. Mr Hamers, credited with helping ING develop its successful online banking platform, in February announced he was leaving to become CEO of Swiss bank UBS Group later this year. Mr Van Rijswijk is a veteran of more than two decades at ING. In 2010 he had been ING's head of corporate clients, and became the head of client coverage at ING's wholesale banking arm in 2014. He joined the company's executive board as chief risk officer in 2017. ING chairman Hans Wijers said Mr Van Rijswijk had the "right combination of experience, leadership skills and deep understanding of our business" to lead the bank. In a statement published by ING, Mr Van Rijswijk said he would not “radically” depart from Mr Hamers’ strategy,which focused on developing the bank’s technology platform and digital products, particularly on its smartphone banking app. “I’m looking forward to further build on our efforts to strengthen ING and enhance our position as one of Europe’s leading digital banks,” he said. “The heart of our strategy sits with the focus on our customers, and that doesn’t change with a new CEO.” – Reuters Facebook pageTwitter feed© 2025 The Irish Times DAC Volume 12 - 2018 | https://doi.org/10.3389/fnbeh.2018.00029 Anxiety disorders are one of the most common mental health problems worldwide but the exact pathophysiology remains largely unknown It has been demonstrated previously that administration of exogenous ketone supplement KSMCT (ketone salt/KS + medium chain triglyceride/MCT oil) by intragastric gavage for 7 days decreased the anxiety level in genetically absence epileptic Wistar Albino Glaxo/Rijswijk (WAG/Rij) rats To investigate the potential role of the adenosinergic system in the pathomechanism of anxiety we tested whether the inhibition of adenosine A1 receptors (A1Rs) influence the anxiolytic effect of the exogenous ketone supplement in the present study we used a specific A1R antagonist DPCPX (1,3-dipropyl-8-cyclopentylxanthine) to test whether it modulates the anxiolytic effect of sub-chronically (7 days) applied KSMCT in the previously tested animal model by using elevated plus maze (EPM) test We administered KSMCT (2.5 g/kg/day) alone by intragastric gavage and in combination with intraperitoneally (i.p.) injected of DPCPX in two doses (lower: 0.15 mg/kg Control groups represented i.p saline and water gavage with or without i.p the level of blood glucose and beta-hydroxybutyrate (βHB) KSMCT alone significantly increased the time spent in the open arms and decreased the time spent in the closed arms Injection of lower dose of DPCPX decreased while higher dose of DPCPX abolished the effect of KSMCT administration on EPM Blood βHB levels were significantly increased after administration of KSMCT while DPCPX did not change the KSMCT induced increase in blood βHB levels These results demonstrate that A1R inhibition modified (decreased) the anti-anxiety effect of KSMCT administration implying that the adenosinergic system may modulate the exogenous ketone supplement induced anxiolytic influence Anxiety disorders, such as panic disorder, post-traumatic stress disorder, and specific phobias, are one of the most common mental health problems worldwide, which disorders may be associated with impairment of quality of life (Li, 2012). Lifetime prevalence of anxiety disorders may be up to 14% worldwide while about 28% of U.S. population suffers anxiety-related disorders during their lifetime (Kessler et al., 2005; Garakani et al., 2006) which approach may lead to a new therapeutic approach the specific mechanism of exogenous ketone supplements/nutritional ketosis on CNS diseases are largely unknown further studies are necessary to better understand the exact effects and signal transduction mechanisms potentially induced by exogenous ketone supplements under different circumstances and in different animal models To examine whether A1Rs can modify the observed KSMCT-evoked changes on anxiety level we used two doses (lower: 0.15 mg/kg and higher: 0.25 mg/kg) of DPCPX intraperitoneally (i.p.) in combination with KSMCT (2.5 g/kg/day we investigated the effect of higher dose of i.p We hypothesized that A1R inhibition may modify the anti-anxiety effect of KSMCT administration All animal treatments and surgery procedures were carried out according to the local ethical rules which are in conformity with the guidelines of the Hungarian Act of Animal Care and Experimentation (1998 European Communities Council Directive 24 November 1986 (86/609/EEC) and EU Directive 2010/63/EU on the use and treatment of animals in experimental laboratories The experimental design was approved by the Animal Care and Experimentation Committee of the Eötvös Loránd University (Savaria University Center) and National Scientific Ethical Committee on Animal Experimentation (Hungary) under license number VA/ÉBNTF02/85-8/2016 and was compliant with the Ethics Codex of institution 305–340 g; breeding colony of WAG/Rij rats at Eötvös Loránd University Hungary) were housed in groups 3-4 under standard laboratory conditions (12:12 h light-dark cycle: light was on from 08.00 AM to 08.00 PM; free access to water and food; air-conditioned room at 22 ± 2°C) Ketone salt (KS: Na+/K+ - βHB mineral salt) was mixed into a 50% solution supplying approximately 375 mg/g of pure βHB and 125 mg/g of Na+/K+ in a 1:1 ratio. Ketone salt was developed and synthesized in collaboration with Savind Inc. (D'Agostino et al., 2013; Kesl et al., 2016) Human food grade MCT oil (~60% caprylic triglyceride and ~40% capric triglyceride) was purchased from Now Foods (Bloomingdale which was mixed with KS in a 1:1 ratio (KSMCT) We demonstrated previously the tolerability and effectiveness of exogenous ketone supplement KSMCT given by intragastric gavage (ad libitum access to normal rat chow + 2.5 g/kg body weight KSMCT by intragastric gavage once/day), which dose induced and maintained ketosis (Ari et al., 2016; Kesl et al., 2016; Kovács et al., 2017) and did not generate side effects KSMCT of 2.5 g/kg/day dosage was administered daily by intragastric gavage for 7 days facing the open arm away from the experimenter the behavior of animals on EPM was video recorded for 5 min and the following data was collected: time spent and number of entries made to open arms The apparatus was cleaned with 70% ethyl-alcohol following with tap water and finally arms were dried with paper towel between rats A blinded observer was present in the testing room separated from the EPM by a curtain while collecting data Blood glucose (mg/dl) and D-βHB (mmol/L) levels were measured following the EPM test from blood taken from the tail vein with a commercially available glucose and ketone monitoring system 60 min after gavage (Precision Xtra™, Abbott Laboratories, Abbott Park, IL, USA, Ari et al., 2016) This ketone monitoring system measures D-βHB only total blood ketone levels (D-βHB + L-βHB + AcAc + acetone) from contribution of racemic KS would be higher Experimental design of WAG/Rij rats (8 animals/groups) days of blood glucose and beta-hydroxybutyrate (βHB) level measurements; DPCPX ketone salt/KS + medium chain triglyceride/MCT In order to induce antagonism of A1Rs without changes in absence epileptic activity and to decrease putative side effects of DPCPX we used 0.15 mg/kg and 0.25 mg/kg DPCPX in combination with KSMCT (2.5 g/kg/day) because these DPCPX doses alone did not change the SWD number in WAG/Rij rats (Kovács et al., 2017 injections (saline and DPCPX) were given 30 min prior to gavage (group 1–5) To investigate the effect of KSMCT and DPCPX alone as well as in combination on blood glucose and βHB levels, we measured these blood parameters on the last day of adaptation period (5th day, baseline), and on the days of the 1st and the 7th treatments (on the 6th and 12th day of experiments; group 1–5) (Figure 1) The body weight of rats was also measured before treatments started (5th day of adaptation period: baseline) and after the last (7th) treatments (on the 12th day of experiments; group 1–5) KSMCT in combination with intraperitoneally (i.p.) injected two doses (0.15 mg/kg n = 8) of DPCPX as well as higher dose of DPCPX (0.25 mg/kg n = 8; DPCPX + water) on the time spent in the areas (center and closed arms) (A) and number of entries to the areas (B) of EPM All results are shown as means ± standard error of the mean (S.E.M.) ketone salt/KS + medium chain triglyceride/MCT; **p < 0.01 and ****p < 0.0001 level of significance and closed arms) and number of entries to the areas of EPM after different treatments are presented (8 animals/group) n = 8; DPCPX + water) on blood beta-hydroxybutyrate (βHB) (A) and as well as body weight (C) on the 1st and 7th day of gavage ketone salt/KS + medium chain triglyceride/MCT; treat treatment day; *p < 0.05; **p < 0.01 Beta-hydroxybutyrate (βHB) levels after different treatments are presented (8 animals/group) Blood glucose levels after different treatments are presented The body weight did not change significantly in either group (group 1–5), compared to baseline and control levels (Figure 3C) In this study we demonstrated that inhibition of A1Rs by i.p. DPCPX dose-dependently decreased/abolished the anxiolytic effect of exogenous ketone supplement KSMCT, in WAG/Rij rats. In addition, we confirmed our previous results showing that sub-chronic administration of KSMCT alone administered by intragastric gavage has anxiolytic effect in WAG/Rij rats (Ari et al., 2016) Our present study demonstrates that KSMCT increased the βHB level in parallel with a decrease in anxiety level whereas DPCPX in combination with KSMCT decreased/abolished the effect of KSMCT administration on anxiety level but did not change the KSMCT administration-induced elevation in blood βHB level DPCPX alone did not change blood βHB level These results suggest that elevated level of βHB may have a role in the KSMCT administration induced anti-anxiety effect via βHB-generated increase in adenosine concentration and through A1Rs we also demonstrated that DPCPX alone was not able to influence anxiety level but abolished the KSMCT-evoked anxiolytic effect on EPM further studies are needed to determine the exact role of different neurotransmitter systems in KSMCT induced anxiolytic effect the role of GABAergic and other transmitter systems such as changes in blood glucose levels cannot be excluded entirely and requires further investigation Based on these results we can conclude that administration of the exogenous ketone supplement may be a potential therapeutic approach in the treatment of therapy-resistant types of anxiety disorders by working at least partially through the adenosinergic system Inducing nutritional ketosis by exogenous ketogenic supplements allows for a rapid and sustained dietary ketosis independent of dietary restriction our present study provided us an opportunity to investigate new aspects of the pathophysiology of anxiety further efforts are needed to elucidate all contributing neurometabolic adenosinergic- and other neurotransmitter system-induced signaling mechanisms of exogenous ketone supplements on anxiety behavior and writing manuscript; DD: interpretation of data writing manuscript; CA: conception of experiments “Compositions and Methods for Producing Elevated and Sustained Ketosis.” Non-provisional patent #62289749 “Exogenous ketone supplements for reducing anxiety-related behavior.” DD and CA are co-owners of the company Ketone Technologies LLC These interests have been reviewed and managed by the University in accordance with its Institutional and Individual Conflict of Interest policies The other author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest This work was supported by ONR Grant N000141310062 and GLUT1D Foundation Grant #6143113500 (to DD) and the National Development Agency of Hungary (under Grant No We wish to thank Tamás Török (ELTE SUC) for the technical assistance and to Quest Nutrition LLC for supporting ongoing studies on this topic ketone salt/KS + medium chain triglyceride/MCT; MCT β-Hydroxybutyrate in the brain: one molecule Marked seizure reduction after MCT supplementation The current status of the ketogenic diet in psychiatry An anticonvulsant profile of the ketogenic diet in the rat doi: 10.1146/annurev.nutr.26.061505.111258 Metabolic dysfunction underlying autism spectrum disorder and potential treatment approaches Ketone ester supplementation attenuates seizure activity and improves behavior and hippocampal synaptic plasticity in an Angelman syndrome mouse model Potential therapeutic interest of adenosine A2A receptors in psychiatric disorders D'Agostino Fear generalization and anxiety: behavioral and neural mechanisms The role and regulation of adenosine in the central nervous system The anxiogenic-like effect of caffeine in two experimental procedures measuring anxiety in the mouse is not shared by selective A2A adenosine receptor antagonists The effects of intra-cerebral drug infusions on animals' unconditioned fear reactions: a systematic review Application of a ketogenic diet in children with autistic behavior: pilot study Adenosine A1 receptors modulate 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Google Scholar Basic mechanisms of generalized absence seizures The ketogenic diet as a treatment paradigm for diverse neurological disorders Thavendiranathan The MCT ketogenic diet: effects on animal seizure models D'Agostino DP and Ari C (2018) Anxiolytic Effect of Exogenous Ketone Supplementation Is Abolished by Adenosine A1 Receptor Inhibition in Wistar Albino Glaxo/Rijswijk Rats Received: 05 December 2017; Accepted: 08 February 2018; Published: 22 February 2018 Copyright © 2018 Kovács, D'Agostino and Ari. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited located on a 4,5 hectare estate in rijswijk a dilapidated barn house has been restored to accommodate the client’s new residence the scheme is clad in darkened douglas wood and is set in the agricultural landscape surrounded by fruit trees while the interior spaces have been re-organized to suit modern-day living workshop architecten approached the design from a new and contemporary angle elements of its previous life still remain and is visible through the barn-house character and gabled roof the key feature of the architect’s response is seen in the identical façade shape that has been repeated four times and visualize as a single extruded volume these façade ‘slabs’ dictate the three zones established inside: a barn area a semi-transparent intermediate zone and the private dwelling this shape –with three distinct openings carved out– offering a view from the residence into the yard and the apple orchard which can be accessed both ends from the semi-transparent zone the renovated scheme hosts a shelter for the sheep and storage the updated interior now facilitates the the client’s daily life the envelope is wrapped in black-stained douglas which is a purpose contrast to the raw wood on the inside the barn is located on a 4,5 hectare piece of land design: workshop architectencontributors:sander gijssenjohan de witlaura berasaluce achaerandio ergin kurt AXOR presents three bathroom concepts that are not merely places of function but destinations in themselves — sanctuaries of style Only a select few make it to the Paralympics With times being the toughest they have in years you must be prepared to adapt and overcome Training and qualifying for the Paralympics during a pandemic is no easy feat as our very own Ashley van Rijswijk has excitedly found out Tash van Rijswijk is Ashley's mother and cannot wait to watch her daughter swim for her life this week has made the Paralympics team and will be competing in two events 100m Breaststroke and 200m Individual Medley At just 20 years old and her first games appearance Ashley is considered a rookie but her journey to qualification tells a different story.  Swimming for The Wagga Swim Club under Gennadiy Labara Ashley and her parents Craig and Tash van Rijswijk have spent many early mornings making the 1.5 hour trip from Tumut to Wagga Wagga in hopes that one day all the hard work would pay off fondly remembers the cold winter mornings spent sleeping in the back of their family car whilst waiting for Ashley's training to finish up It takes a village and with unwavering support from both parents it is no wonder Ashley has been able to pursue her passion to compete at the highest level on the world stage.  hopes to make a splash in both her Paralympic events Having qualified for the 100m Breaststroke (S14) and 200m Individual Medley (S14) her events will begin on the 29th of August The Southern Sports Academy Athlete attributes a good pre-race routine to her focus with Ashley making sure she always gets her skipping in right before any race It is this preparation and dedication that has led Ashley to the world stage The journey has not always been smooth sailing with van Rijswijk overcoming a neck injury in time to swim in the qualifiers but that may just be what sets this young woman apart from the rest The determination it takes to be a professional athlete is second to none with van Rijswijk being a true example of this hard work.  Out of all Australian athletes travelling to Tokyo for the Paralympics there are many making their first appearance at the games- with Ashley being one of them It is deemed as a major human rights movement with the title representing 15 per cent of those who live with a disability worldwide WeThe15 wish to fight the stigma around disability ensuring that their disabilities are not ignored or looked past and that they are definitely not superhuman Tune in to watch our very own Ashley Van Rijswijk swim her heart out 29th August 9:38 am (Tokyo Time) (10:38 am AEST) 31st August 9:49 am (Tokyo Time) (10:49 am AEST) 24th August 9:15 pm AEST Streaming Live Channel 7  Begin Wednesday 25th August- Thursday 2nd September (10 am AEST) Begin Wednesday 25th August- Friday 3rd September (6 pm AEST) the Tokyo 2020 Paralympic Games streaming time zones are only differing by one hour (AEST) You can also subscribe to 7plus to watch anything you may have missed over the course of the 2020 Paralympics From all of our team here at IDEAS we would like to wish Ashley and all the athletes representing their country good luck Donate now List my service for free List an Event Learn more about NDIS Make a complaint   Accessibility Consumer Info & Privacy Disclaimer Sitemap   02 6947 3377   ideas@ideas.org.au IDEAS acknowledges the traditional owners of country throughout Australia We pay our respects to them and their cultures Copyright © 2023 IDEAS   Version - 2021.53   "We are extremely pleased we found someone for this key position who knows the organization inside out and can make a flying start." The Executive Board has appointed Eric van der Geer-Rutten-Rijswijk as Secretary of the University who joined the Executive Board in November last year.  currently director of the TU/e Education and Student Affairs (ESA) service already has a long career behind him at TU/e His previous positions include managing director and education director both at the Department of Industrial Engineering and Innovation Sciences where he also received his doctorate in 2008.    “We are extremely pleased we found someone for this key position who knows the organization inside out and can make a flying start,” says Executive Board President Robert-Jan Smits I am convinced that he is the right person to provide the Executive Board with optimum support in strategy and policy “It is a great honor for me to now also start making my contribution to TU/e at the highest executive level,” Van der Geer commented on his appointment “We have a very ambitious Executive Board and there are many major developments around the university so I am looking forward tremendously to getting started in my new role With my knowledge of the organization and the primary processes I hope to be able to contribute even more to TU/e in this pivotal role.”  Daisy van der Schaft will serve as acting director for the ESA service Recruitment for a new ESA director will start very soon The European Patent Office (EPO) will have a new office building at Rijswijk The new tower will replace of the existing 42-year old building at the site The new tower will replace of the existing 42-year old building at the site The foundation stone-laying ceremony for the construction of the new building was held in June 2014 the new 80,000m² building has sustainable features and flexible workspaces and is co-designed by architects Jean Nouvel and Diederik Dam The entire project including the demolition of the old 86m-tall office tower and the creation of landscape for the new office building is expected to be completed by 2019 It is one of the biggest office construction projects in Netherlands The EPO site at Patentlaan 2 in Rijswijk is being converted into a more sustainable office building with Energy Performance Coefficient (EPC) values of 30% which is below the average established by the Dutch Building Decree the new building will house approximately 1,750 staff the building emerges from a landscaped water body reflecting the glass façade The flags of 45 European countries will be featured on both sides of the main entrance The new 100m-high office tower will be a steel structure featuring a sophisticated double glass façade with an iridescent hue The 6m-high lobby is illuminated by natural light and covers the whole perimeter of the building The reception desk is fitted with a set of linear periscopic mirrors reflecting the image of the horizon stretching beyond the building entrance Construction on the International Criminal Court broke ground in 2013 and is expected to be finished by the end of 2015 The long central corridor of the transparent building leads to different units accessible through a set of sliding doors and the access corridor The office spaces also feature extensions to leisure spaces The floors are made of linear unpolished wood resembling boat decks. Aluminum, polished wood and fine stainless-steel joinery are used for the interior finishing the building will also feature a training centre A consortium named TBI Group comprising J P van Eesteren Wolter & Dros and HEVO was awarded the design-build contract for the project in July 2013 TBI Group was selected out of the three consortiums shortlisted in an open international design competition conducted by EPO in 2012 Deerns supports the TBI Group by providing and commissioning the entire electrical mechanical and the vertical transportation design for the building Zonneveld ingenieurs is the structural engineer for the project Give your business an edge with our leading industry insights View all newsletters from across the GlobalData Media network. Share via...Gift this articleSubscribe to gift this article Gift 5 articles to anyone you choose each month when you subscribe ING Groep appointed Steven van Rijswijk as chief executive officer as the Dutch lender contends with rising compliance costs and pressure from low interest rates SaveLog in or Subscribe to save articleShareCopy link Gift 5 articles to anyone you choose each month when you subscribe. Follow the topics, people and companies that matter to you. Read MoreBanking productsLatest In Financial servicesFetching latest articles Stichting Herontwikkeling tot Studentenhuisvesting Delft and the Municipality of Rijswijk will convert three unused office blocks into 312 homes One of the office blocks that will be turned into student housing (Photo: SHS Delft) The size of the student houses will range from four to 16 person households there will also be 12 studios and 15 self-contained homes for PhD candidates “We also plan to create a few homes for students with residence permits but this is not yet definite so we are not sure if it will go ahead,” says Noor Zaat Secretary of Stichting Herontwikkeling tot Studentenhuisvesting (refurbishment for student housing The office blocks to be converted are on the Plaspoelpolder industrial area on the Polakweg This not only means that the homes will be within cycling distance of the TU Delft campus but also of the InHolland University of Applied Sciences and The Hague University of Applied Sciences The area where the student rooms will be created is currently a business area with a lot of empty buildings “We contacted the three owners of the office blocks about a year ago when we saw that some of the builldings were partly empty,” explains Zaat “We signed a 10 year agreement with the buildings’ owners which means that they will remain student housing during this period.” According to the latest forecast by Kences – the umbrella organisation for student accommodation providers – the Netherlands currently has a shortfall of 26,500 student rooms This shortfall is only expected to rise in the years to come had previously agreed to build an additional 2,500 student units by 2026 but this is far from enough to meet the expected shortfall SHS Delft was founded to create student accommodation for TU Delft students The students design the homes themselves that they then have built in empty buildings Do you have a question or comment about this article We use cookies to enhance your browsing experience We use cookies to help you navigate efficiently and perform certain functions You will find detailed information about all cookies under each consent category below The cookies that are categorized as "Necessary" are stored on your browser as they are essential for enabling the basic functionalities of the site We also use third-party cookies that help us analyze how you use this website and provide the content and advertisements that are relevant to you These cookies will only be stored in your browser with your prior consent You can choose to enable or disable some or all of these cookies but disabling some of them may affect your browsing experience Necessary cookies are required to enable the basic features of this site such as providing secure log-in or adjusting your consent preferences These cookies do not store any personally identifiable data Functional cookies help perform certain functionalities like sharing the content of the website on social media platforms Analytical cookies are used to understand how visitors interact with the website These cookies help provide information on metrics such as the number of visitors Performance cookies are used to understand and analyze the key performance indexes of the website which helps in delivering a better user experience for the visitors Advertisement cookies are used to provide visitors with customized advertisements based on the pages you visited previously and to analyze the effectiveness of the ad campaigns Aussies are big fans of a big house – a castle In fact, at an average floor size of around 240sqm, Australia is home to some of the largest residences in the world. But it’s not just the size of a house that matters, it’s the vibe. The serenity. Adding a bit of charm. We take a look at what Aussies are dreamin’ of for their dream homes – and what is going straight to the pool room. What Australians have on their wish list changes very little year to year, or even decade to decade, says PropTrack senior economist Paul Ryan. Apart from the pandemic transforming how homes are used, he says property seekers tend favour the same range of features and are willing to pay increasing amounts for more space. What makes Australians most house proud? Picture: Getty Images “We’ve seen continued strong demand for larger homes to accommodate people spending more time in their homes and different usages of different rooms,” Ryan says. Not just a nation girt by sea, we also seem to crave a splash of chlorine. Over the last 12 months, pools were the most-searched term among houses on realestate.com.au and the second-highest for units. “The pool is a pretty perennial feature of an Australian home,” Ryan says. “I don’t think you could imagine a truly luxury home without a pool.” Matthew van Rijswijk, Development Director at Frasers Property Australia, says buyers loves the idea of a pool or a gym in a development, whether a residential estate or apartment building. But they are also quite conscious about having to pay for them, he adds – perhaps making it more aspirational than dealbreaker. Residents at Ed.Square in NSW can enjoy a leisurely pool area. Garages are the second most searched term for house hunters, with a double garage seen as a big plus for buyers. “I’m surprised how much people prioritise garages for new homes,” says Ryan. “But it’s both for storage and car-focused living.” Frasers Property Design Director Hallum Jennings says the importance of parking depends on where you live – in terms of accessibility, transport options, space and demographic. For example, inner-city homes are likely to have less room available and residents may preference other forms of transport. “A couple of 20-year-olds I work with plan to never own a car, so they only car share, which is interesting,” Jennings says. It’s little surprise that air-conditioning is a consistently important feature for Aussies, with cooling and heating often seen as a necessity in the home. However, with rising energy costs, Ryan says it makes sense to design and build homes that don't require artificial heating or cooling. Van Rijswijk says a home’s position plays a big role, with a north-facing aspect offering natural temperature control benefits as well as hard-line sustainability. “When it comes to aspect, there’s a camp who know about it and a camp who don’t,” he says. “I think once you know about it, there’s no going back.” Aussies still love a centrepiece kitchen, especially in luxury homes, says Jennings. He says the entertainer’s kitchen is a status symbol for many homeowners, sporting features such as high-end appliances, island benches and exquisite cabinetry. A beautiful kitchen never goes out of style. Butler’s pantries are increasingly popular too, where food is prepared and stored behind closed doors. However, he says not all Australians are keen cooks, especially in inner-city areas, thanks to easy food delivery. “Recently we went through one of our apartments and the occupants are using the oven to store their shoes,” he says. From the sausage sizzle to local markets, a sense of belonging is important to Australians. Part of choosing a dream home is location and what that location offers. Popular features for community connection include proximity to “open space, schools, social services, retail and nature”, says David Mazzotta, Senior Community Development Manager at Frasers Property Australia. Views of the streetscape are also sought-after, he says, allowing for passive surveillance that enables both a sense of safety and familiarity. Van Rijswijk says people want visual and acoustic privacy in their own space, but not completely closed off from the neighbourhood. In other words, you can shut a window or close the blinds and enjoy a sanctuary or open things up and feel part of the action. “It’s vibrancy, as in is there somewhere that I can be connected to others, and then it’s about privacy,” he explains. “They may seem contradictory, but buyers want the option of being private in their own space or connected in a social space.” Mazzotta says Aussies love variety in their homes, with different spaces within designs for family and friends to congregate or retreat. Multi-purpose rooms are rising in popularity, whether used as a study – one of the top ten most searched terms – or a home gym, craft room, nursery or guest bedroom. Spare rooms are used for a range of reasons, from a dining space to a home office. Picture: Getty Images “The demand for studies or extra bedrooms for workspaces has exploded since the pandemic lockdowns,” says Ryan. “That hasn’t been something that has receded.” Games rooms are a stalwart of the Aussie dream home, Jennings says, particularly in the suburbs. “This room always has something in it, like a pool table or a piano,” he says. We all know Aussies and barbies go together like pies and sauce, so a top outdoor area is high on the wish list – from premium patios and gardens to full alfresco kitchens. “Obviously we focus a lot more on barbecues and alfresco than some countries,” says Jennings. For those without a front lawn or backyard, communal green spaces rate highly, whether incorporated into a new development or simply within the suburb. Van Rijswijk says green access – including parks, tree-lined streets and leafy landscapes – are places that people want to live in. “A diversity of spaces fosters different connection environments,” he says. Dual living and granny flats made the top ten search terms for houses – and with cost of living increasing, shared properties and multi-generational living is coming back in vogue. While granny flats are not new, they are becoming more innovative and comfortable in terms of design and specs. Jennings points to classic sitcom Happy Days, where the Fonz used to live in the apartment above the Cunninghams’ garage, as an example of annex-style living in popular culture. “That’s where the term ‘Fonzie flat’ came from, and that’s very much an Australian thing.” Want to learn more about Frasers Property Australia? related tagsBuying And Building New happier neighbourhoods that enhance the way people live life together With a focus on place-making and community development we create diverse places that are connected we’ve built over 145,000 homes for Australians and created city-shaping places in which people feel proud to belong third parties have written and supplied the content and we are not responsible for it completeness or reliability of the information nor do we accept any liability or responsibility arising in any way from omissions or errors contained in the content We do not recommend sponsored lenders or loan products and we cannot introduce you to sponsored lenders We strongly recommend that you obtain independent advice before you act on the content realestate.com.au is owned and operated by ASX-listed REA Group Ltd (REA:ASX) © REA Group Ltd. By accessing or using our platform, you agree to our Terms of Use. Access our patent databases and search tools Go to overview  Technology insight report on plastic waste management Practical information on filing and grant procedures Go to overview  Find out how the Unitary Patent can enhance your IP strategy the Official Journal and other legal texts Go to overview  Keep up with key aspects of selected BoA decisions with our monthly "Abstracts of decisions” Go to overview  From ideas to inventions: tune into our podcast for the latest in tech and IP The European Patent Academy – the point of access to your learning Go to overview  Have a look at the extensive range of learning opportunities in the European Patent Academy training catalogue Go to overview  Track the latest tech trends with our Patent Index The EPO welcomed 750 visitors to its new premises in Rijswijk last weekend as part of the Netherlands' national heritage days (Open Monumentendag) This is the first time that the EPO has participated in the country-wide annual event and it is also the first time that the Office's new building in The Hague has opened its doors to the public "The European Patent Office has deep historical roots in Rijswijk so we were delighted to be invited to take part in the Open Monumentendag," said EPO President António Campinos "It was a fantastic opportunity to open our Rijswijik office so everyone had an opportunity to learn more about our new building our work and the different ways in which we support innovation." Over the course of the two-day event visitors from the local area Amsterdam and from as far away as Neuenhaus took guided tours of the EPO's new building They learned about its environmental sustainability features enjoyed sweeping views from the rooftop and had a behind-the-scenes look at the work of a patent examiner Having seen the construction of new landmark building over four years visitors expressed their appreciation for the opportunity to see the facility from the inside The EPO's new Rijswijk office building was designed by the internationally renowned architects Jean Nouvel and Diederik Dam It has several remarkable functions: the double glass facade plays an essential role in the climate concept and houses hanging gardens with 300 different types of plants The building has an office garden on the roof from where visitors have a panoramic view of the surrounding area at a height of over 100 meters Construction began in 2014 and the building was officially opened in June 2018 in the presence of King Willem-Alexander some 2 000 staff work in the distinctive new office where its advanced technical infrastructure supports EPO patent examiners and other staff in searching and examining European patent applications coming from companies and inventors from around the world The building was recently named ‘Best Tall Office Building' by the Council on Tall Buildings and Urban Habitat Open Monumentendag Photos of the new EPO site in The Hague EPO's new premises in The Hague receives international award as "Best Tall Office Building" Two boys were arrested on Friday night for taking away flowers that had been placed at the war memorial in Rijswijk for Remembrance Day the flowers at the memorial were also taken away the wreaths were torn apart and thrown into the pond next to the monument The police received a report that a number of young people had stolen the flowers commemorating the victims of World War II When the police were on their way to the memorial of the fallen at Laan Hofrust the officers saw two boys walking with flowers in their hands Prosecutors fined them for negligent assault the police were unable to determine whether the boys had anything to do with the incident on the night of May 4 to 5 "We are still investigating who did this," police said Mayor Huri Sahin van Rijswijk was shocked to hear about the destruction of the memorial after Remembrance Day ANS - “Agenzia iNfo Salesiana” is a on-line almost daily publication the communication agency of the Salesian Congregation enrolled in the Press Register of the Tibunal of Rome as n 153/2007 This site also uses third-party cookies to improve user experience and for statistical purposes By scrolling through this page or by clicking on any of its elements With the recent signing of contracts to extend their commitment until 2024 the initiators of the 'Rijswijk Centre for Sustainable Geo-Energy' (RCSG) have once again underlined the importance of the centre Geothermal energy can play a substantial role in the energy transition it can be used to heat houses and buildings sustainably Geothermal heat is expected to be able to meet a quarter of the Netherlands' heat demand by 2050 The Ministry of Economic Affairs and Climate Change the Municipality of Rijswijk and TNO have established the RCSG to accelerate the development of geothermal heat The RCSG was officially opened on 5 March 2020 and offers companies active in the field of geothermal energy the opportunity to make use of the advanced laboratory The centre has 20 installations covering the entire spectrum of underground drilling All the facilities are present to test and experiment with new drilling techniques and materials under high pressure and temperature conditions comparable to those in the Dutch subsurface almost all the conditions in the Dutch subsurface can be simulated There are only a few such centres in the world The RCSG offers companies access to modern facilities that they would otherwise not be able to use due to the high investments involved in this type of research The extension of the commitment will enable the centre to continue to grow and to provide even better facilities for companies wishing to experiment with new drilling techniques and materials The RCSG will enable companies and knowledge institutes to work closely together to develop new technology and take major steps in the transition to a sustainable energy system billed as the ‘slimmest and tallest glass and steel construction of its kind in europe,’ the building houses around 2,000 staff members over 85,000 square metres the structure draws upon the dutch landscape with its reflective glass surface reproducing the sky the project is located in the dutch town of rijswijk, near the hague image © ossip van duivenbode for european patent office (also main image) the office building — which jean nouvel collaborated on with amsterdam-based firm dam & partners — measures 156 meters (512 ft) in length and 107 meters (351 ft) in height the slender design allows light to pass through the building houses around 2,000 staff members over 85,000 square metres image © ossip van duivenbode for european patent office the structure draws upon the dutch landscape image © ossip van duivenbode for european patent office a double glass façade houses hanging gardens, which contain 300 varieties of plants image © ronald tilleman for european patent office the slender design allows light to pass through creating a sense of transparency image © ronald tilleman for european patent office construction began on the project in 2014 image © ronald tilleman for european patent office