This article is also available in Italian / Questo articolo è disponibile anche in italiano the European Commission unveiled its Vision for Agriculture and Food a document outlining a roadmap for the future of Europe’s agri-food sector and supply chain The strategy aims to bolster the sector’s competitiveness and resilience by prioritising simplification and digitalisation to enhance efficiency across the entire production chain the document appears to present internal contradictions and lacks clarity on the role of farmers in this transformation there is no clear vision on how these principles will be put into practice We discussed these topics with Cristina Guarda who is deeply engaged in food system policies What is your overall opinion of the EU Vision on European food systems presented by the Committee on Agriculture The Vision (here you can find the document editor’s note) presents a sharply focused analysis of the current state of agriculture—a sector characterised by an ageing workforce and by uncertain incomes which are significantly below both the European average and those of other economic sectors A field in which there is a lack of services in rural areas together with a pronounced gender gap that represents an additional challenge through the analysis of environmental and climate impact on agriculture how much production capacity depends on these factors it presents a highly lucid picture of the sector’s current problems Rather than addressing these challenges in line with the Farm to Fork strategy—which aimed to strengthen farmers’ roles within the food supply chain through progressive measures—we are witnessing a shift in direction Agriculture Commissioner Christophe Hansen appears to be steering policy back towards a more conservative approach focused solely on competitiveness and attractiveness of the sector accompanied by popular terms like simplification and innovation Could you explain this last statement in more detail The document makes no concrete reference to what is actually meant by simplification It provides no practical examples of which bureaucratic aspects Europe intends to remove through this political strategy Nor is it clear whether it is about deregulation or real it is evident that this would do nothing to ease the administrative burden on farmers Another issue is that much of this bureaucracy is not imposed by Europe but stems from national strategic plans There seems to be an almost ideological stance as if technological advancement alone can provide all the answers It paints a future where technology will miraculously solve every problem—advanced systems to capture emissions assisted evolution technologies (AET) to create ultra-drought-resistant seeds these practices are not yet a viable option no one is investing in research areas that could make a difference: improving seeds for organic farming developing agroecological practices to reduce water consumption and generating ecosystem services essential for food production The Vision also fails to acknowledge those exploring new economic distribution models based on short supply chains High-performing research and innovation networks already exist built on democratic research and the direct involvement of local communities in experimentation Yet there is no mention of any of this in the document the risk remains the same: promoting costly technological solutions which inevitably lead to small and medium-sized farmers taking on debt as they often don't have the resources to afford them What are the main proposals that the Greens/EFA group is promoting we have outlined key priorities for our vision of the future CAP It is clear to us that payments should be tied to job creation rather than simply distributed based on cultivated land That is why we propose capping payments at €60,000 per farming business and redistributing the remaining CAP funds to those who need them most—new and young farmers and funding supporting the transition to climate- and biodiversity-friendly agriculture Every farmer should have the right to a fair wage we want to make economic eco-schemes both more attractive and more rewarding We know very well that farmers who adopt agroecological practices require more time and space for production they provide an ecosystem service that benefits the entire community and all economic sectors The principle we propose is simple: those who produce ecosystem services must be paid for their work Farm businesses must be assessed as a whole with financial recognition for all measures taken to protect the environment This would mean creating a new and stable income stream What are the other elements of your proposal We have a dependency problem from other countries: we import chemical fertilisers The Commission’s Vision suggests addressing this by boosting domestic production promoting more extensive livestock farming and tackling livestock emissions through the previously mentioned “innovations” You cannot talk about extensive farming without reducing the number of animals reared A more sustainable rearing strategy must go hand in hand with a structural review of the sector This is why we advocate for a genuine strategy on protein diversification Encouraging more sustainable livestock systems is not enough—we must also ensure equal support and promotion for plant-based and alternative protein sources But this transition cannot happen without engaging citizens and policymakers cannot afford to ignore it Yet these two aspects are entirely absent from the current Vision despite being well addressed in the Farm to Fork strategy We propose clear and transparent labelling that provides information on environmental impact and animal welfare standards—ensuring consumers can make informed choices The underlying problem in this Vision is that it speaks of resilient production systems while simultaneously focusing strongly on exports That is why we ask that the focus must first be European we oppose the Mercosur agreement because we support a model that valorises regional markets and strengthens short supply chains rather than one built on global competition We advocate for alternative partnerships that are more sustainable and resilient per- and polyfluoroalkyl substances: how important is it today to fully understand the real distribution of PFAS and to start remediation interventions to deal with a situation that is now critical in some areas There are two key issues that must be tackled we need to stop the production and release of PFAS which requires investment in research to develop viable alternatives we must find ways to eliminate the PFAS already present in the environment Halting production alone will not solve the problem—we also need to understand how to destroy them effectively and safely We already know how to capture PFAS using activated carbon But the real challenge lies in destruction Current methods—including microwaves and high-temperature thermal processing—are extremely expensive and often generate even smaller Serious investment in research is essential to develop effective PFAS destruction methods without creating new risks We must also work to prevent companies from continuing to release them into the environment—for instance by promoting closed-loop systems that stop contaminated wastewater from reaching rivers and aquifers farmers in affected areas also need support in adopting cultivation techniques that prevent plants from absorbing PFAS from the soil This is not just a water pollution issue—the contamination of soil has major implications for agricultural production Another crucial step is banning PFAS in industries where safer alternatives already exist there is no justification—replacement solutions for PFAS are available and manufacturers must be pushed to adopt them without further delay The path forward is clear: stop production and release This article was originally published on the website of Circular Economy for Food a project of the Università di Scienze Gastronomiche di Pollenzo of which Materia Rinnovabile is a media partner is an independent publisher and comparison service interactive tools and other content are provided to you for free as self-help tools and for informational purposes only They are not intended to provide investment advice NerdWallet does not and cannot guarantee the accuracy or applicability of any information in regard to your individual circumstances and we encourage you to seek personalized advice from qualified professionals regarding specific investment issues Our estimates are based on past market performance and past performance is not a guarantee of future performance We believe everyone should be able to make financial decisions with confidence And while our site doesn’t feature every company or financial product available on the market the information we provide and the tools we create are objective The investing information provided on this page is for educational purposes only does not offer advisory or brokerage services nor does it recommend or advise investors to buy or sell particular stocks Fact CheckedHow is this page expert verified NerdWallet's content is fact-checked for accuracy It undergoes a thorough review process involving writers and editors to ensure the information is as clear and complete as possible Andy Rosen Crypto wallets provide a way to protect secret information that gives you control over your digital assets This is not something you want to leave to chance; if you lose access to these “private keys,” you may never get your cryptocurrency back The first question when choosing a crypto wallet is whether you want a hot wallet or a cold wallet The main difference between a hot wallet and a cold wallet is that hot wallets are connected to the internet while cold wallets are not Other questions to ask when comparing wallets include: How many types of digital assets are supported, how easy is it to move crypto offline, into a cold wallet, and are there resources for in-app staking or rewards programs offering add-on services such as trading or staking in exchange for fees A hot wallet makes it relatively easy to carry out transactions using crypto but it may be more vulnerable to hackers who could theoretically reach your crypto over the internet Here are NerdWallet’s top picks for hot crypto wallets Zengo has emerged as a next-generation wallet that claims to build on the technology of previous wallets Zengo uses a form of cryptography known as multi-party computation Zengo claims this is the first instance of a consumer wallet (as opposed to an institution) using MPC Seed phrases and private keys have been at the heart of self-custody in crypto since the beginning but Zengo aims to enhance security while doing away with the issues that come from managing your own keys and seed phrases no Zengo wallets have been hacked or stolen We look at more than 15 factors to evaluate crypto wallets Crypto.com Onchain (formerly Crypto.com DeFi Wallet) is a wallet created by a company mostly known for its crypto exchanges. It’s specifically tailored for use in what is known as decentralized finance (DeFi) which is a sector of the crypto world focused on lending saving and other financial products that don’t rely on a central broker Users of Crypto.com Onchain can use their crypto holdings to interact with DeFi products both on their mobile app and in a browser extension It also has a desktop app that integrates with Ledger hardware wallets Crypto.com Onchain emerged as a winner here thanks to the wallet's connection to the main Crypto.com app This makes it extremely simple to use Crypto.com's well-reviewed centralized trading app then transfer assets to your own self-custody wallet there is a 0.0008 BTC withdrawal minimum (a little more than $60 at the time of last update) So you'd need more than $60 worth of BTC to instantly transfer it to your Onchain wallet all-purpose crypto wallet whose users can access their crypto via mobile Users of Guarda can move crypto into cold storage through an integration with the hardware wallet Ledger Guarda also has staking programs available Exodus offers a solid set of software tools trade or stake cryptocurrency directly from their wallets and it has an integration with the Trezor cold wallet intended to help people easily move crypto from hot to cold storage also has a solid library of explanatory content for people who are learning about crypto Assets supported: More than 10 million digital assets and over 100 blockchains Trust Wallet also does not provide a full list of supported cryptocurrencies on its website it's likely the wallet will be able to support just about any cryptocurrency you come across The company operates the largest U.S.-based crypto exchange But Coinbase Wallet is a separate product that allows users to store cryptocurrency themselves rather than keeping it in the custody of Coinbase Because the Coinbase Wallet was created by Coinbase it integrates easily with its company’s exchange and may be a good introduction for users who haven’t used a non-custodial wallet before The free application has some other strengths such as mobile and browser-based connections to decentralized applications It also lacks some functionality offered by competitors though its browser extension connects to the Ledger hardware wallet with the option to manually add unsupported ERC-20 assets If you’re a regular user of applications on the Ethereum blockchain MetaMask can store any digital asset that’s built on Ethereum MetaMask also integrates with many of the “Web3” applications that exist on the Internet and require crypto transactions to work MetaMask has mobile and browser-based wallets It also offers staking and DeFi apps through its MetaMask Portfolio feature and integrations with multiple hardware wallets including Ledger and Trezor Just remember that if you’re not a big user of Ethereum and its related tokens There is a large selection of hot wallets on the market, and most of them can support hundreds or even thousands of cryptocurrencies. They also generally can hold at least some types of NFTs, or non-fungible tokens and many connect directly to exchanges where you can buy or sell crypto Cold wallets are usually gadgets that are disconnected from the internet that help you store sensitive crypto information because you have to buy a piece of actual hardware that’s set up to store your crypto Because they are not connected to the internet they may be harder for other users to reach hardware wallets come preloaded with software and other usability and security features that make the process smoother you may want to consider details such as price and security measures you should check to make sure the hardware you’re considering will work with your software wallet Here are NerdWallet’s top picks for cold crypto wallets Ledger is one of the best-known names in crypto wallets and Ledger can integrate with many popular software wallets such as Crypto.com and Guarda plus a dedicated desktop app and a browser extension Ledger also has two-factor authentication available and a library of educational content for users » You can buy Ledger wallets directly from the Ledger shop here Trezor offers some of the highest-end hardware available in crypto storage While its entry-level model (the Tezor Model One) costs around $49 it also has a more expensive model (price at last update was $169) with a touch screen Trezor has integrations with other crypto firms such as Exodus though it also provides built-in services such as staking and crypto purchases through its software products as well as a mobile app (Trezor Suite Lite) for Apple and Android One slight inconvenience: Trezor wallets do not have Bluetooth capability although the company notes that this is a deliberate decision meant to reduce the wallet's vulnerability to cyberattacks » You can shop all of Trezor's products in the company's official store here Non-custodial crypto wallets are the type of storage option preferred by many crypto enthusiasts because they place you in control of your own private data. Unlike when you keep assets on a cryptocurrency exchange you don’t have to trust a third party to secure your private keys That’s not to say non-custodial wallets are without risk They are less forgiving of errors such as lost passwords and you have to trust that your wallet’s hardware and software will work as intended And moving assets between wallets regularly can become costly because of transaction fees imposed by underlying blockchain networks For these reasons some crypto users have multiple types of wallets: some for long-term safekeeping and others for active trading One way to choose a wallet is by looking at the website of the cryptocurrency you’re hoping to store. There are many single-purpose solutions built for individual cryptocurrencies. For example, MetaMask is often considered a top Ethereum wallet because it focuses solely on ERC-20 tokens Electrum is among the top Bitcoin wallets because it's built specifically for Bitcoin power users But if you’re planning to protect multiple kinds of cryptocurrencies in one place » Not ready for a wallet? Here are the best crypto exchanges and platforms You can also keep your crypto on a cryptocurrency exchange but then you're trusting a third party to secure your assets allow you to buy crypto through accounts with them as well Bitcoin ETFs and Ethereum ETFs are also an option for 401(k) investors or others who can't invest directly in crypto — but these involve trusting someone else to safeguard your crypto investment If you want total control of your crypto assets Hot crypto wallets generally offer an account recovery process if you forget your username or password although the terms of that recovery process may vary between providers If you physically lose a cold crypto wallet, or it breaks, don't despair — the crypto isn't actually gone; cold wallets just store private key information needed to access or move your crypto. The cold wallets we review offer users the ability to regenerate their wallets using a seed recovery phrase in the event of loss That depends on the broker. Some, like Robinhood, do work with external wallets, while others do not. For more information, check out our roundup of the best crypto exchanges and apps Once you've set up a crypto wallet, you can buy crypto to put in it via crypto exchanges, certain traditional brokers, certain money transfer services, Bitcoin ATMs and more. Our article on how to buy Bitcoin gives a good overview of the current options for buying crypto. This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Read today's Portuguese stories delivered to your email 23 lots have been purchased by a Brazilian agri-food company from Guarda's logistics platform will purchase 23 lots of the Guarda logistics platform to establish a facility in the agri-food industry which will create pioneering food products for the European and American markets and requires an investment of 116 thousand euros “It is a business group with seven factories and employing around a thousand people in the state of São Paulo It is a supplier to highly regarded international brands having had a turnover of around 40 million euros in 2023 and has now decided to develop a new manufacturing unit in Guarda” The agri-food industry is an investment which is very important for the city not only because of the direct jobs created but also because of everything that can help boost Guarda’s economy and companies “This is a great Christmas gift from this executive to Guarda because we committed ourselves to make this deal happen and now we hope it can become a reality in the near future” Sérgio Costa claims that the project is now in development and will cost several million dollars We appreciate that not everyone can afford to pay for our services but if you are able to we ask you to support The Portugal News by making a contribution – no matter how small You can change how much you give or cancel your contributions at any time Send us your comments or opinion on this article Reaching over 400,000 people a week with news about Portugal The year 2024 has brought a lot of firsts for Green MEP Cristina Guarda Not only is this the Italian lawmaker’s first term in the European Parliament but she also welcomed her first baby at the end of September.  But her own welcome into the world of EU politics has been less than warm.  the MEP has worked remotely in the last weeks of her pregnancy Home-office was working well for Guarda — that is until she requested to join the upcoming commissioner hearings remotely.  The hearings give MEPs the chance to grill and ultimately vote on the commissioner-designates the only Green who sits on both the agriculture and regional committees next week’s hearing gives her the chance to directly quiz hard-right candidate Raffaele Fitto who will oversee both agrifood and rural affairs in his role as executive vice president of cohesion and reforms “I’m not even asking to vote — I’m just asking to speak to put my question to him in my own words,” the MEP told EUobserver Her request to speak during next Tuesday’s hearing was denied in late October by a conservative majority in the governing body of the European Parliament – the Conference of Presidents (CoP) The coalition consisted of four men from the European People’s Party (EPP) European Conservatives and Reformists (ECR) Patriots for Europe (PFE) and the Europe of Sovereign Nations (ESN) four women from progressive forces backed Guarda’s demand an EPP spokesperson group said allowing such a move could open the door to “all kinds of requests to intervene online” from MEPs in situations such as sick leave or travelling and for other meetings or even during plenary sessions a spokesperson from the European Conservatives and Reformists (ECR)  group agreed on the need to address the issue long-term given the “time constraints” the group encouraged Guarda to put her question in writing and have it read out by a colleague from her group which is the currently proposed compromise agreement.  But this is not an acceptable solution for the Green MEP “It's frustrating to see someone else do your job and [ask] your question without your background and your knowledge,” she said But Guarda sees the move as an attempt from conservative men to keep women 'in their place' “My message is that a woman should decide for herself how much time she spends with the baby and how much time she spends working,” she said adding that it “helps her mental health” to continue being able to continue participating in meetings.  The situation is familiar to parliament president Robert Metsola was also unable to vote on key decisions after having her fourth child back in 2016 This included voting on the EPP group’s election of Antonio Tajani as nominee for the parliament president or any of the December 2016 plenary votes Attributing the slow progress on parental rights to “technical and political” reasons an official in Metsola’s office said she “remains committed” to finding a way forward that is “legally sound and which does not put unnecessary pressure on women who are on maternity leave” Her office said she has in recent years approached various parliamentary technical groups and relevant services “multiple times” to explore options — but that experts warned this raises a “number of technical Her team also said that Metsola is committed to keeping this issue high on the political agenda sees “no legal or technical argument” to block Guarda’s participation pointing out that all the necessary technical infrastructure was put in place both for meetings and votes during the Covid pandemic Reintke — who put Guarda’s request to the CoP meeting —  described the parliament’s decision as proof of as “lack of political will” This is “striking” given that the groups that opposed the move position themselves as 'pro-family and pro-children' yet “chose to deny a young mother’s chance to participate,” she added.  who chairs the Parliament’s FEMM committee “Being a mother or father should not prevent MEPs from fulfilling our obligations and represent the citizens who elected us,” Galvez added.  Together with group leaders from the Socialists have written a statement in an effort to reverse the parliament's decision “We believe that this refusal impedes the rights of an MEP and is a discriminatory limitation to the work and political mandate of an elected member not being able to travel after having had a baby but who wants to undertake her work voluntarily,” the statement reads.  the move should also be a “wake-up call” for the parliament to re-think its approach to parents and carers. “This is not the 1980s anymore – we have the digital means to make this possible and we should do all we can to make the parliament accessible,” she also said Natasha Foote is a Brussels-based freelance journalist 0 CommentsEU PoliticalHealth & Societyby Natasha Foote But her own welcome into the world of EU politics has been less than warm. To read this story log in or subscribeEnjoy access to all articles and 25 years of archives Become a member for as low as €1,75 per week EU PoliticalHealth & SocietyExclusiveAuthor BioNatasha Foote is a Brussels-based freelance journalist Natasha Foote is a Brussels-based freelance journalist In today’s rapidly growing crypto economy finding the right wallet can make all the difference Whether you’re just stepping into the world of Bitcoin or you’re a seasoned investor juggling multiple digital assets the wallet you choose is the foundation of your entire crypto experience Among the many options available, Guarda Wallet consistently ranks at the top of the list as both the best bitcoin wallet and the best crypto wallet But what makes it stand out in a competitive market filled with alternatives Let’s explore why Guarda Wallet is the ideal choice for crypto users in 2025 and beyond The Rise of Guarda Wallet: A Brief Overview born out of a vision to offer users full control over their crypto holdings while maintaining top-tier security and user experience it has grown into one of the most trusted wallets in the crypto space Unlike many wallets that focus only on Bitcoin or a handful of coins This means that users can manage hundreds of cryptocurrencies without compromising their ownership or relying on third parties Non-Custodial by Design: True Control Over Your Crypto One of the standout features of Guarda Wallet is that it's non-custodial meaning users maintain complete ownership and control over their private keys Guarda never stores your personal data or wallet access credentials and everything stays encrypted on your device This setup is vital in a world where exchanges and custodial services have become prime targets for hackers you eliminate third-party risks and maintain full sovereignty over your assets—making it a top candidate for the best bitcoin wallet title A Wallet That Works Everywhere: Cross-Platform Support Modern investors use multiple devices daily—from desktops to smartphones to browsers Guarda Wallet understands this and delivers a seamless cross-platform experience - Web Wallet (accessible from any browser) This level of flexibility is rare in the crypto wallet space Whether you’re checking your Bitcoin balance on the go or staking your altcoins at home Guarda Wallet has you covered—another reason why it’s considered both the best bitcoin wallet and one of the most functional wallets on the market today Best Bitcoin Wallet Features for Everyday Users Let’s dive deeper into the features that make Guarda Wallet the best bitcoin wallet for daily use: 1. Instant Transactions with Adjustable Fees Guarda allows users to customize transaction fees based on network activity and urgency This is particularly helpful for Bitcoin users who want to avoid overpaying when the network is congested This phrase is essential for wallet recovery offering peace of mind in case your device is lost or damaged Guarda comes with a built-in exchange feature that allows users to swap BTC for other assets directly within the wallet No need to move funds to an exchange and risk exposure This kind of convenience is a game-changer for anyone who frequently trades or rebalances their portfolio 4. Bitcoin Support with Advanced Options and manage your BTC wallet with advanced features like custom fees These tools make Guarda Wallet not just user-friendly but also highly functional for experienced Bitcoin users Beyond Bitcoin: The Best Crypto Wallet for All Your Digital Assets Although Guarda Wallet shines as the best bitcoin wallet It is also considered one of the best crypto wallets due to its support for 50+ major blockchains and over 400,000 tokens You can store and manage a wide range of assets This multi-asset capability makes Guarda a true one-stop shop for anyone involved in the broader crypto space You don’t need multiple wallets—just one Guarda Wallet that does it all In addition to secure storage and seamless asset management Guarda Wallet offers an entire suite of crypto services: Guarda supports staking for several coins including Tezos You can stake directly from the wallet and earn passive rewards without any technical setup Guarda lets users buy Bitcoin and other cryptos using a credit or debit card This makes it easy for new users to enter the crypto space without having to register on centralized exchanges Guarda also includes a token generator tool that lets you create custom tokens on supported blockchains making it easy to see your collectibles directly from your interface A subscription to The Baltic Times is a cost-effective way of staying in touch with the latest Baltic news and views enabling you full access from anywhere with an Internet connection. Subscribe Now! 2025 © The Baltic Times /Cookies Policy Privacy Policy Statement: on the possibility for MEP Cristina Guarda to participate remotely in Raffaele Fitto’s Hearing we are appalled with the decision taken in the Conference of Presidents last 24 October 2024 to refuse the request of our fellow MEP Cristina Guarda to participate remotely in the Hearing of Commissioner-designate We believe that this refusal impedes the rights of a Member of the European Parliament and is a discriminatory limitation to the work and political mandate of an elected Member not being able to travel after having had a baby but who wants to undertake her work voluntarily We would like to stress that the request of Cristina Guarda only refers to her intention to pose an oral question to a Commissioner-designate Given the specific circumstances of the case we believe there should be no technical nor political barrier for Cristina Guarda to speak remotely for one minute and represent herself in a crucial political meeting as a Hearing of a Commissioner We also wish to stress that such derogatory decisions are taken on a regular basis at Coordinators level for Committees without undermining the right to maternity leave We believe that allowing her participation to this meeting is essential to ensure that constituents are not unrepresented while their Member is on leave or pregnant if she is able and wants to continue performing her role Exercising one's mandate and representative role is not only the right of the elected person but it is also essential to guarantee the effective participation of citizens in the EU’s democratic life call on the President to find a way to allow Ms Cristina Guarda exercise her right and mandate and be able to participate remotely and formulate a question to Commissioner-designate The European Parliament in its Gender Action Plan adopted in 2020 commits as a gender sensitive parliament to provide equal access and participation for all genders and to work for improved work-life balance conditions and better accommodate family commitments We ask therefore on the President to live up to this commitment We expect a close attention to this urgent matter and we look forward to any workable solution Guarda do Embaú is home to a world class wave that breaks consistently year-round and is known as one of the best surf spots in Brazil It is situated directly adjacent to the Serra do Tabuleiro State Park the largest conservation area in the Brazilian state of Santa Catarina which boasts a stunning natural environment including the Madre River The combination of world-class waves in a pristine coastal setting has nurtured a vibrant conservation-minded surf community that seems to grow stronger by the year The influence of the local community and the legacy of the late Brazilian surfing legend and Guarda do Embaú local lends national significance to Guarda do Embaú’s approval as a WSR The World Surfing Reserve approval holds the promise to harness Brazil’s love of the sport for a deeper commitment to coastal activism and protection amongst the Brazilian surf community and policy-makers Guarda do Embaú is home to a world- class wave that breaks consistently year-round and is known as one of the best surf spots in Brazil which boasts a stunning natural environment including the Do Madre River Guarda do Embaú’s approval has national significance Brazil’s booming surf industry and growing dominance on the professional surf tour (WSL) has made it the second most popular sport after soccer The World Surfing Reserve approval holds the promise to harness Brazil’s love of the sport for a deeper commitment to coastal activism and protection amongst the Brazilian surf world and policy-makers former President and current Director of Communications for the Association of Surfing and Preservation of Guarda do Embaú was the principal organizer for the WSR application Kito said ‘The World Surfing Reserve approval represents the possibility to trace the history and the environmental characteristics of Guarda do Embaú We seek to create a management plan to preserve and protect our coastline in response to the environmental issues that might threaten our waves and local tradition.” Guarda do Embaú is home to a legendary wave that breaks at the mouth of the powerful Do Madre River throughout the year The best months for waves are during rainy season (summer and part of autumn) but waves are on offer throughout the year hollow left-hand barrels the break off of a scenic rocky headland The wave works best with a East swell reaching up to 10 feet Guarda do Embaú hosts professional and amateur local state and national surf competition such as Rip Curl Groom Search 2007 when Gabriel Medina and Felipe Toledo were crowned For generations Guarda do Embaú was just a small surfers discovered the epic waves and it is now internationally recognized as one of the best surf spots in Brazil Each decade has ushered in an expansion of local surf culture and witnessed a growing influence over other aspects of the community Guarda do Embaú is now a full -ledged surf community and surfing has played an important role in creating a strong environmental ethic in the village Guarda is also a multi-generational fishing village so there is a deep inherent respect for their coastal resource Guarda do Embaú beach closes down for mullet fishing and surfing is not allowed a small deserted beach where the access is made by the coast of the North side of the beach of Guarda is a good option The history of surfing in Brazil cannot be written without mentioning Guarda do Embaú Guarda do Embaú is located in a pristine coastal environment flanked by rivermouths The village is situated directly adjacent to the Serra do Tabuleiro State Park The combination of world-class waves in a pristine coastal setting were strong attribues in their favor during the selection process created in 1975 is the largest conservation area with full protection in the state of Santa Catarina and occupies an area of approximately 87,405 ha taking up about 1% of the territory of Santa Catarina that protects a wide diversity of habitats (mangrove distributed in plains and mountains) where 9 municipal districts are partially inserted in the park This park provides water to agricultural food production and industrial processes and also holds the main water supply source of capital Florianópolis and surrounds Guarda do Embaú and Serra do Tabuleiro State Park are home to several endangered species incliuding: the macuco (Tinamussolitarius) the parrot-of-breasted purple (Amazona vinacea) 2002).Guarda do Embaú village is located in a sandbank area (herbaceous/shrubby coastal sand-dune habitats) and the beach is separated from the village by the Da Madre River The river has its mouth in the north part of the beach and its water has good quality The river is responsible to form a sandbank that stretches for several kilometers between the river and the sea Planejamento Estratégico / Strategic Planning  The Coalition Summit held in Santa Cruz on June 7 through June 9 was a historic event for Save The Waves and the protection of surf ecosystems more broadly It was the first time in the history of the World Surfing Reserves program that we brought the entire network together with all 12 WSR’s represented has continued to work diligently towards the long-term protection of the most important ecosystem attribute for the coast It is this river that flows from the mountains of the Serra do Tabuleiro State Park down to the breaking waves at Guarda that is the Local Stewardship Council of the 9th WSR stated that intervention at the mouth of Rio da Madre is necessary Guarda do Embaú is home to a legendary wave that breaks at the Da Madre River mouth throughout the year For generations Guarda do Embaú was just a small surfers discovered Guarda’s epic waves and it is now internationally recognized as one of the best surf spots in Brazil campaign alerts and news from our Coalition around the world and 10% off your first purchase at the Save The Waves Shop Privacy Policy   |  Terms & Conditions Powered by Team of Horses   |   ©2015-2025 Save The Waves Coalition In the tranquil alpine setting of Lenzerheide the «Guarda Val Maiensaess-Hotel» blends rustic coziness with luxurious amenities in its contemporary retreat Hotel Co-Director Phillip Arnold provides an exclusive insight into the unique allure of the establishment Experience an unforgettable getaway at the Buendner Guarda Val Maiensaess-Hotel with our exclusive Finews reader offer Immerse yourself in the perfect combination of relaxation Price from CHF 578.00 per person/package in a double room Validity: June 27 to December 20, 2024Booking: Online at guardaval.ch with the promo code: «finews» or call +41 81 385 85 85 This offer and the following interview are published as part of a commercial collaboration between the «Guarda Val Maiensaess-Hotel» and finews.com why did you become a hotelier/hotel director It was my childhood dream to travel the whole world and to create something positive together with and for people What are five features that set your hotel apart from others Welcome to Guarda Val: Exterior of the reception (Image: Sundroina Pictures/Guarda Val) How would you define hospitality and excellent guest service I expect our 68 employees to offer no more than what they would arrange for good friends and acquaintances when hosting at home and a wide variety of Limitless experiences to enhance their hospitality Which prominent guests have you welcomed to your hotel Our guests come to us for private relaxation every guest enjoys the same status with us What does your hotel offer for the «perfect weekend» for two Guarda Val Stailetta: Private Wellness-area (Image: Sundroina Pictures/Guarda Val) Two different dining establishments with three kitchens and the unique rooftop terrace (where the name Guarda Val – «view of the valley» – originates from) which serves as a «living room» for our hotel guests providing cozy moments outside their rooms there is the well-designed Guarda Sana wellness area and our rustic rooms and suites as «cocooning» retreats The hotel's location in the middle of the Buendner mountains offers exceptional panoramic views of the Oberalbstien valley All of this is provided in an environment with people who genuinely love to pamper from the heart… Hotel room with rustic Grisons coziness (Image: Sundroina Pictures/Guarda Val) our wellness area will receive some small updates.. the future lies in creating lasting moments and unique experiences for our guests and sufficient personnel resources into this How is the gastronomy in your hotel developing With our young executive chef Paul Berberich we reinvent classic French cuisine in a new way with each new menu In addition to the gourmet restaurant and the Buendner Stube we increasingly cook and serve in a traditional manner over an open fire in the midst of nature Gourmet Restaurant Guarda Val (Image: Sundroina Pictures/Guarda Val) What is the best advice you have received from your mother or father Pride comes before a fall & honesty is the best policy Philip Arnold has been Co-Director of the Guarda Val Maiensaess-Hotel since spring 2021 His partner Bettina Arpagaus supports him in the same role After training as an insurance clerk and a stay abroad in New Zealand Arnold attended the Hotel Management School in Lucerne After various positions both domestically (Giardino Ascona Beau Rivage Palace Lausanne) and abroad (HUKKA Lodge Taupo) he ended up at an altitude of 1600 meters in Sporz he took over the management of the unique establishment in Lenzerheide finews.com publishes on its own Web-TV-Channel interviews with well-known figures of Swiss finance. + More on this topic + More on this topic + More on this topic Rafael Reis second and Iñigo Elosegui was third in Guarda 40-year-old Luis Angel Mate (Euskaltel-Euskadi) outsprinted his breakaway companions to win stage 4 of the 85th edition of the Volta a Portugal Rafael Reis (Sabgal-Anicolor) was second and Iñigo Elosegui  (Kern Pharma) took third in Guarda Mate was part of the 11-rider breakaway which escaped after 32 kilometres of racing on the 164.5km stage and at one time held a maximum gap of over 6 minutes to the field Afonso Eulálio (ABTF Betão-Feirense) retained the leader’s yellow jersey Racing continues on Monday with 176.8km stage 5 from Penedono to Bragança Results powered by FirstCycling Heavy rain fell on burn scar areas of the Serra da Estrela mountain range. The areas had seen intense forest fires during the summer and by late August the government declared a state of calamity downed trees and debris raced down hillsides around the village of Sameiro Images show damage to buildings and infrastructure At least 4 vehicles were dragged into the river Zêzere several vehicles were dragged by the force of the water there are houses and businesses that have been affected “At the moment we have no information about the injured but we are on the ground evaluating all the time The Portuguese Institute of Sea and Atmosphere (IPMA) issued warnings for severe weather from 11 September 2022 as Extratropical Cyclone Danielle was forecast to make its way across the Iberian Peninsula IPMA reported the city of Guarda recorded 83.7 m of rain in 24 hours on 13 September emergency teams carried out interventions for flooded buildings in Lomar e Arcos in Braga; Sacavém e Prior Velho in Lisbon and Castro Daire in Viseu Overall Portugal Civil Protection recorded more than 350 occurrences related to the bad weather mostly for wind damage and minor flooding in the districts of Lisbon and Setúbal Breaking NewsHeadlinePortugal Richard Davies is the founder of floodlist.com and reports on flooding news South Africa – Mining Dam in Jagersfontein Collapses Leaving 3 Dead, 4 Missing Italy – 7 Dead, 3 Missing After Severe Flooding in Marche Region Cookies | Privacy | Contacts © Copyright 2025 FloodList Truemetal vive grazie al suo pubblico. Quando compri qualcosa dai nostri link, potremmo guadagnare una commissione. Scopri di più Il commento della band:“Un viaggio nella sensualità e nel desiderio primordiale dove la carne diventa un tempio e la caccia alla passione si svolge come un antico rituale un richiamo a trascendere i piaceri ordinari e ad entrare nella Pleasuredome un luogo dove il divino e l’animalesco si fondono” “Goldstar” è disponibile in preorder: https://ImperialTriumphant.lnk.to/Goldstar-AlbumPR La copertina è stata realizzata da a Zbigniew M the masked triumvirate Imperial Triumphant continues their exploration of the urban and arcane The band has found inspiration in the sound of metal pushed to its darkest extremes Recorded in early 2024 with longtime collaborator and producer as the final project recorded at Marston’s Menegroth Studios in Queens the album was done in a breakneck five days the experience felt like the universe was aligning,” the band observes who is basically a fourth member of the band to us offering his incredible artistry and expertise which only deepened the connection we had to the music The sound that we captured in that sacred space was the crystallization of everything we’ve worked for and the memories of those sessions will resonate within us for years to come Music exists as a force beyond the infinite.” With new single “Lexington Delirium” and the unveiling of Goldstar the band reflects on what they’ve achieved – and what’s to come: “Imperial Triumphant’s upcoming album is a journey that feels both timeless and otherworldly and we are beyond excited to share it with the world in 2025 The music we’ve created feels like it was born from a deeper and we’re truly in love with every part of it Our new video for ‘Lexington Delirium’ is a perfect reflection of that energy filmed atop the majestic Chrysler Building We’ve all admired its art deco beauty for years and standing on top of such an iconic structure felt like stepping into a different age—an age of ambition and grandeur Working with Brendan McGowen was an absolute pleasure as his vision and creativity are greatly appreciated.” Goldstar is a long cool drag and as intense an urban fever dream as only Imperial Triumphant can deliver Imperial Triumphant will join the 2025 Decibel Magazine Tour for an extensive North American run alongside headliners and labelmates Mayhem Fans can expect a gilded mask-lift when Imperial Triumphant returns to the stage; new masks and an upgraded show will be part of their live experience with Goldstar and beyond See below for all dates; Decibel Magazine Tour tickets can be purchased at: www.decibelmagazine.com/events/tour I Cirith Ungol hanno annunciato il nuovo album dal vivo intitolato “Live at the Roxy”, in uscita il prossimo 25 aprile per Metal Blade Records. Il concerto è stato registrato all’iconico Roxy Theatre sul Sunset Strip in occasione del release show del loro ultimo album “Dark Parade“ Quella sera i Cirith Ungol hanno eseguito il disco per intero più alcuni classici come ‘Join The Legion’ ‘Black Machine’ e ‘Atom Smasher’ Di seguito la prima anteprima del DVD: il video di ‘Down Below’ One of the world’s most iconic music venues – the Sunset Strip’s Roxy Theatre – hosted a legendary 2024 gig by one of the world’s most iconic metal bands The one-night-only performance was an album release show for the band’s 2023 Dark Parade LP It captured the lineup at the height of its considerable powers along with a set of classic songs including “Join The Legion,” “Frost And Fire,” “Black Machine,” and “Atom Smasher.” The end result is a stellar live album and DVD There was no choice other than the Roxy for CIRITH UNGOL to record this momentous live collection “It’s owned by a Hollywood music legend Lou Adler,” notes cofounding drummer Rob Garven “and is next door to the famous Rainbow Bar and Grill which includes the Whisky and The Starwood [now gone] so every time we played one of these historic venues It was great to see many of our friends and fans from all over the world at the show.” there has been a live bootleg record famous in the underground from their last appearance there in1984 titled Cirith Ungol I felt it fitting for the band to return there 40 years later to officially document a live performance in a way the guys would be proud of and Goldenvoice all came together in support to actually make it happen.” CIRITH UNGOL‘s Live At The Roxy holds its own against other legendary live records “The Who made an extremely powerful album with Live At Leeds had several pretty spectacular live albums and 1993’s Uriah Heep Live is another outstanding live album It’s hard to accurately capture all the sound and feeling of a live concert and I think our Live At The Roxy does also.” Live At The Roxy will be released on April 25th via Metal Blade Records today the band presents a taste of the monumental event with video footage of “Down Below.” “This song strung together by the haunting acoustic guitar is a gift to all of you on this Doomed Planet the culmination of all the pain and suffering absorbed into our being from the pandemic It features some of my best drumming and one of [guitarist] Jimmy [Barraza]’s best solos As the song rises to the ultimate crescendo all this pent-up emotion is unleashed on the listener with our final gasping breath Truly a churning maelstrom of metal chaos descending!“ Live At The Roxy will be available digitally and as a 2xCD/DVD set or 2xLP/DVD set in the following color variants: “The band’s strong late-period form is now also documented on an impressive live album with a whopping 100 minutes of playing time includes the complete release show for the 2023 album The Dark Parade Recorded at the legendary Roxy Club on L.A.’s Sunset Strip CIRITH UNGOL practically offer a complete showcase of their work culminating in the frenetically acclaimed ‘Join The Legion’ The audience sound is also beautifully captured so that Live At The Roxy can be recommended to every CIRITH UNGOL cultist to heart.” – Deaf Forever (DE) FRISCO – FC Dallas has waived midfielders Bryan Leyva and Bruno Guarda as well as forwards Ruben Luna and Matias Jara The waived players will become available via waiver draft in December following MLS Cup Leyva joined the professional ranks in 2009 as FC Dallas’ first Homegrown signing the young Texas native has played nine games He started and played 69 minutes in a 2011 friendly versus Tigres He also scored three goals and tallied one assist in the MLS Reserve League in 2011 Luna signed with FC Dallas as a Homegrown player on July 30 Luna has appeared in 22 games and scored two goals He led the MLS Reserve League in goals with 10 during the 2011 and led FC Dallas in goals scored during CONCACAF Champions League that same season The contracts of both Homegrown players expired following the 2012 season and FC Dallas elected not to renew either player the team will continue to support the two Academy graduates as they pursue the next opportunities in their careers FC Dallas acquired Guarda in a trade with the Colorado Rapids on July 28 The Brazilian midfielder played for head coach Schellas Hyndman at SMU where he was a two-time Hermann Trophy semifinalist scoring one goal and tallying three assists in MLS play He appeared in 12 games making nine starts in 2008 and appeared in 11 games with five starts in 2011 Guarda made four appearances and started one match Argentine striker Matias Jara signed with FC Dallas in August 2012 Jara joined the club from Argentine second division side Guillermo Brown He did not appear in any matches with the FC Dallas first team It’s all fun and games until the credit card bills arrive The idea of sending your mom seven swans a-swimming seemed just ducky back in December is when we realize just how many halls we decked over the holidays It’s time to tighten our belts and use restraint with every purchase I kissed a lot of frogs to find this under-$10 beauty from Portugal. The 2020 Guarda Rios red blend is a bottle you can enjoy long after your tax return arrives from the IRS Phil Your Glass:Happy hour at D’Agnese’s is triple the fun I sampled it on four occasions with an array of different foods It’s a blend of 40% aragonez (tempranillo) with trincadeira and Alicante Bouschet balancing out the remainder I don’t care if I can pronounce the name of the grape The flavors of black raspberry and red plum were perfect with my carryout order from R&B Street Tacos & More I came upon this new-to-me Mexican restaurant while driving north on State Road just before I got to Steels Corners Road My sister and I were quite happy with our chicken tostada The winery suggested fish as a good pairing with this tinto blend so I picked up an order of seared ahi tuna from the Giant Eagle Market District’s sushi counter The pairing was so delicious that I will try a bottle next time I pick up carryout sushi I am quite certain this wine will stretch your wine drinking pleasure and budget Don’t forget to buy six bottles to get your 10% discount You might want to keep a few bottles on hand for when you neighbor Gordie the Guzzler stops over Phil Your Glass: Clay Shannon is a shockingly delicious cabernet for less than $20 Look for another budget-friendly wine in my column next week Buy this wine at Mustard Seed Market Montrose Send me an email at philyourglass@gmail.com with any wine questions and follow me on Instagram @pmasturzo_philyourglass Community and conservation efforts rally around surf protected area Brazil’s Guarda do Embaú was officially dedicated as the 9th World Surfing Reserve with over 200 people in attendance for the three day ceremony The celebration was the culmination of more than three years of intensive work building the Local Stewardship Council completing a Stewardship Plan and finalizing an economic study of the area the Guarda do Embaú surf ecosystem is one of the most classic Brazilian surfing locations as well as one of the most biodiverse areas in the Atlantic Coast Rainforest of Brazil “All of the Brazilian surf world knows about this place and it has some of the best waves in the entire country,” said former Surfing World Champion Adriano de Souza “I am proud to be involved in the protection of Guarda.” the Local Stewardship Council drafted the Stewardship Plan for the Reserve to define and implement important projects to improve the water quality of the Rio da Madre This resulted in a new water quality monitoring program municipal approval and funding for construction of a wastewater treatment plant “Guarda do Embaú is one of the most unique places I have ever been What the community has done for conservation of the area as part of the World Surfing Reserve is nothing less than incredible,” said Save The Waves Executive Director “They have set the bar so high for what can be achieved through the World Surfing Reserves program and are a model for the rest of the WSR network.” The Guarda do Embaú World Surf Reserve unites the legally protected areas of the Serra do Tabuleiro State Park and an Environmental Protection Area for the Southern Right Whale as part of a special multiple-use zonation The efforts and accomplishments of the WSR have also inspired the creation of and highlighted the need for a network of protected surfing areas throughout the coastline of Brazil “We are so proud of all of the work that we have done with the Local Stewardship Council and Save The Waves and today everyone in Guarda do Embaú knows about this huge honor and acknowledgement,” said Marcos ‘Kito’ Gungel President of the Local Stewardship Council and Reserve Manager In attendance were former Surfing World Champion Adriano de Souza Portuguese Big Wave Surfer and WSR Co-Founder Brazilian Movie Star and Environmentalist Mateus Solano Big Wave Surfer and Brazilian TV Host Ricardo Bocão and Save The Waves Executive Director Nik Strong-Cvetich and STW Conservation Programs Manager Trent Hodges For more information on the Guarda do Embaú World Surfing Reserve, please visit here. Puerto Rican from Movistar Team reaches rest day in sixth place overall after tough team battle between W52 and stage winner Figueiredo's Efapel The crazy pace local outfits always show at the Volta a Portugal was again shown at Sunday’s stage four which exploded quite far from the finish in Guarda A combined attack from W52 – Porto and Efapel put race leader Alejandro Marque’s Atum / Tavira squad between a rock and a hard place where Frederico Figueiredo (EFP) took the day’s honours The Portuguese rider attacked into the tough climb of Videmonte (Cat-2) from a very reduced GC peloton (35 riders) split at the very start with two Movistar Team riders able to keep up with them: Lluís Mas y Abner González today wearing the under-23 leader jersey for the first time had some great support in the end by the Spaniard who brought back by himself half of the two-minute advantage Figueiredo and Amaro Antunes (W52) held over the penultimate climb to Guarda (Cat-3) Abner was the third strongest within those in the peloton and sits almost at the same overall place he had a day prior: he’s now in sixth 1’10” from Marque and 45″ away from the podium The ‘Grandíssima’ will enjoy its rest day on Monday before resuming Tuesday with the Cat-2 Santo Tirso / Nª Sra Cover picture (c): Photo Gomez Sport We are using cookies to give you the best experience on our website You can find out more about which cookies we are using or switch them off in settings This website uses cookies so that we can provide you with the best user experience possible Cookie information is stored in your browser and performs functions such as recognising you when you return to our website and helping our team to understand which sections of the website you find most interesting and useful Strictly Necessary Cookie should be enabled at all times so that we can save your preferences for cookie settings we will not be able to save your preferences This means that every time you visit this website you will need to enable or disable cookies again This website uses Google Analytics to collect anonymous information such as the number of visitors to the site Keeping this cookie enabled helps us to improve our website Please enable Strictly Necessary Cookies first so that we can save your preferences Please enable JS and disable any ad blocker Lisbon, Portugal, Aug. 14, 2022 (GLOBE NEWSWIRE) -- Guarda Wallet is thrilled to announce the release of its own prepaid Visa card You can use this card anywhere Visa is accepted which means you can use it for online shopping you'll never have to worry about exchange rates or fees That's because you can top up the card from your Guarda Wallet automatically converting your cryptos into Euros The card comes in 2 forms — Plastic and Virtual The virtual card will be generated on the mobile app after successful registration while the Plastic card will be sent to your provided address Download the Guarda Wallet mobile app to order the card apply for the card and make sure you are in one of the eligible countries Note: The card will be available to the following EU countries: Austria meaning you have complete control over your public and private keys It is a cryptocurrency wallet that lets you send and store cryptocurrencies all in one place It supports over 50 blockchains and 400,000 assets some of which can be staked for passive income If you're looking for a convenient and easy way to spend your crypto look no further than the Guarda Wallet prepaid Visa card I BAEST tornano a colpire annunciando l’uscita del loro quarto album “Colossal” in arrivo il 15 agosto 2025 su Century Media Records Prodotto da Tue Madsen agli Antfarm Studio (Heaven Shall Burn l’album contiene 9 tracce per 42 minuti Saranno presenti in veste di ospiti speciali Jesper Binzer voce dei D-A-D in “King Of The Sun” e gli ORM in “Misfortunate Son” L’artwork dell’album è stato creato da Solomacello Disponibile il nuovo singolo “Misfortunate Son (feat ORM)” accompagnato da un video diretto da Moshmallows: BAEST commented about the “Colossal” album and the band’s current activities as follows: “Paying homage to the heavy metal roots of our music This album showcases our passion for melody and a new direction for our death metal Keeping the energy of former releases and adding new flavours to the inferno ‘Colossal’ stands out as an honest Recording it over the course of 2 years at Antfarm Studio with Tue Madsen has been a different but exciting process leaving a lot of space in between material released off the album with the two first singles ‘Colossus’ and ‘Imp Of The Perverse’ being almost a year old by now We found that giving songs more time to grow felt right and we also had to reinvent our own style and sound in that process which leads to our satisfaction with ‘Colossal’ – it’s a broad album sound wise Playing some of the new tracks live on our recent tour with Danish rock legends D-A-D was helpful in cementing the appeal of the new tracks and helped us finish the album recordings between those shows we embark on our first ever US/North America run supporting Arch Enemy and we are following this tour up with a ton of European festivals This will be the perfect platform to show the new material and get feedback from the fans – see you on the road!” BAEST also checked in with the following comment about the song: “‘Misfortunate Son’ is the newest single release from our upcoming 4th album ‘Colossal’ Recorded at Antfarm Studio with Tue Madsen (The Haunted it brings forth a blend of melody and brutality The song showcases our passion for classic heavy metal riffing while incorporating the signature catchiness we always strive for with BAEST We brought our Danish heroes ORM to add some eerie vocals BAEST will be making their debut tour across USA and Canada supporting Arch Enemy on their “North American Blood Dynasty 2025 Tour” alongside Fit For An Autopsy and Thrown Into Exile Stay tuned for further news on BAEST and “Colossal” coming soon… Essential digital access to quality FT journalism on any device Complete digital access to quality FT journalism with expert analysis from industry leaders Complete digital access to quality analysis and expert insights complemented with our award-winning Weekend Print edition Terms & Conditions apply Discover all the plans currently available in your country See why over a million readers pay to read the Financial Times has introduced a prepaid Visa card for EU countries The wallet can automatically convert cryptocurrency into euros which can then be used at retailers that accept Visa The card is available in plastic and virtual forms Customers can download the Guarda Wallet mobile app to store the card virtually Get the latest news and resources from ATM Marketplace LISTEN TO THE EXCLUSIVE PREMIERE OF “I DIDN’T BREAK” FROM LINDSAY SCHOOLCRAFT AND GAIA GUARDA ONLY ON OUTBURN.COM Featured on the C Squared Underground Music Special compilation fellow harpist Lindsay Schoolcraft(ex-Cradle of Filth) collaborated with Gaia Guarda on the song “I Didn’t Break.” “‘I didn’t break’” was born in the depths of the uncertainty of 2020 by two stubborn musicians that decided to do a collaboration even though they had no access to the studio due to the pandemic restrictions and give a second life to a pantyhose that I had lying around as a pop filter The fact that the production was such a big challenge makes the song even more special to us And I do recommend that listen to it while taking a bath From A revolutionary Brazilian music and arts movement in 1960s Brazil Tropicalia gave the world the initial offerings of superstars Caetano Veloso Ernesto Lechner discusses another Brazilian movement from the mid-'60s: Jovem Guarda While Tropicalia drew on Brazilian influences the artists of Jovem Guarda were more directly influenced by The Beatles and music from abroad Hear Lechner's Jovem Guarda Spotify playlist on this page Become an NPR sponsor the gas fee will subsequently increase if it is paid in TRX instead of energy by 1.5 times because the fees for TRC-20 tokens are calculated in energy for each transaction The platform was developed as a foundation for developers to create dApps and build a decentralized Internet TRON has a better throughput thanks to its layered architecture Tron network can run up to 2,000 transactions per second (TPS) without users paying high gas fees But with the recent news on the increase in fees one might be wondering how to make transactions without paying fees Energy is used to calculate smart contract fees. Energy, unlike bandwidth, can only be gained by staking TRX on Guarda Wallet to earn 3.86% in APY for gasless TRC-20 transactions All currently active TRON addresses receive 1,500 free bandwidth points every 24 hours which users can use to make gas-free TRC-10 and TRX transactions If the account does not have enough Energy or Bandwidth to cover the transaction fees Contact Information: Rina Dyom Marketing Manager rina@guarda.co This content was issued through the press release distribution service at Newswire.com Breakout four-piece Sleep Theory — vocalist Cullen Moore and drummer Ben Pruitt — were one of the biggest success stories of both 2023 and 2024 The band dominated the radio airwaves and charts; were one of the most buzzed about bands on the festival circuit; won over fans at every show they played; and turns heads at press with everyone from Revolver to Loudwire to Alternative Press to Forbes to Ones to Watch unable to deny the band’s DNA-distinct blend of hard rock Sleep Theory storm headlong into 2025 by announcing their eagerly awaited debut album which arrives on May 16 via Epitaph Records which offers a stunning display of diverse rock flavors was produced by David Cowell and mixed by Zakk Cervini (Bring Me The Horizon Pre-order it here Sleep Theory are also thrilled to share the video for the new single “Static,” which serves as the album’s opener It starts with a ferocious roar before launching into their signature dynamic Sleep Theory combine energetic hard rock and metalcore alongside the powerhouse vocalist Cullen Moore they became the fifth most-played artist on Active Rock radio Afterglow and the Paper Hearts EP merge heavy rock with pop and R&B producing anthemic bangers and emotional ballads and Amazon Music as an Artist to Watch in 2025 they’ve become one of heavy music’s biggest breakouts the quartet proves ready to ascend to the next level InvestingInvestingGuarda Crypto Wallet Review 2024: Pros Cons and How It Compares{"@context":"https://schema.org","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"name":"Back to NerdWallet homepage","item":"https://www.nerdwallet.com/"},{"@type":"ListItem","position":2,"name":"Investing","item":"https://www.nerdwallet.com/h/category/investing"},{"@type":"ListItem","position":3,"name":"Guarda Crypto Wallet Review 2024: Pros Cons and How It Compares"}]}Advertiser disclosureYou’re our first priority.Every time.NerdWallet Guarda can be good for storing a wide variety of cryptocurrencies across multiple devices The bottom line: Guarda’s cryptocurrency wallet gives you a lot of options if you want to store your cryptocurrency on an internet-connected device supporting thousands of cryptocurrencies using mobile Pros: Large selection of supported cryptocurrencies; useful tools across desktop Cons: Closed-source code; limited NFT support Where Guarda shines Where Guarda falls short What Guarda is best for Guarda at a glance Full details about Guarda's ratings Other details you should know about Guarda Is Guarda right for you? How we review crypto wallets Selection: Guarda can store a vast number of digital assets Its developers say the overall selection is close to 400,000 trade and earn rewards on cryptocurrency without leaving it in the custody of a centralized exchange Closed-source: Self-custody wallets like Guarda can have advantages over third-party storage options such as exchange-based services that can be vulnerable to theft or loss Guarda lacks some advanced security perks competitors offer such as fully open-source coding that allows users to look under the hood at how it works Limited support for non-fungible tokens: While Guarda says additional functionality for NFTs is coming soon users have few options for transactions using NFTs at the moment and it does not feature two-factor authentication Guarda says it supports about 400,000 digital assets It also has features including purchases and swaps Guarda is a hot wallet that can connect to dedicated offline storage devices made by Ledger Guarda has helpful educational content along with features to help you review the performance of your crypto portfolio Self-custody crypto wallets like Guarda avoid some potential pitfalls of leaving your crypto on an exchange you can't lose your crypto if an exchange fails or suffers a devastating hack there are tradeoffs when keeping digital assets in your care And if you lose your password and recovery phrase Guarda has some features that add security including multisignature support for Bitcoin and Ethereum Multisignature requires multiple users to approve a transaction adding a hurdle for anyone trying to drain your holdings Guarda lacks some other features that competitors have so you have to trust the developers when they say their code is secure having a project's code open to general review makes it possible for people who understand programming to highlight potential issues Guarda says it has made as much of its information public as possible without compromising trade secrets Guarda also lacks two-factor authentication some wallet developers argue that 2FA is redundant for wallets because they offer a security phrase that you can save in case you get locked out Guarda allows users to carry out most transactions directly from their wallet software cryptocurrency purchases and trades are available (for a fee) and the product supports staking for 15 assets the wallet supports about 400,000 different cryptocurrencies These range from established cryptocurrencies such as Bitcoin to obscure and rarely used tokens supported by Ethereum's network that while Guarda can store certain kinds of NFTs it has fewer options than competitors for viewing and making transactions with these one-of-a-kind digital assets Guarda is a hot wallet; it stores the keys to your cryptocurrency using software on an Internet-connected device You alone (not the creators of Guarda) have custody of the information needed to spend or transfer your crypto Suppose you're interested in another layer of security for your crypto which stores your cryptocurrency on a device like a thumb drive that is not connected to the Internet Guarda has a feature that allows users to convert cryptocurrency to cold storage devices sold by the wallet maker Ledger Guarda has several ways to access your crypto wallet, including desktop, mobile and browser-based applications. Keep in mind that you'll need to enter your security/recovery phrase each time you set up your wallet on a new device Guarda's user scores in the Apple and Android app marketplaces are substantially lower than other wallets we've reviewed Guarda has a library of information about cryptocurrency and its content is designed to answer questions users may have as they navigate the storage process The company's desktop and mobile apps also offer basic tools for tracking and managing the performance of your crypto portfolio NerdWallet's ratings are determined by our editorial team The scoring formula for online brokers and robo-advisors takes into account over 15 factors customer support and mobile app capabilities.4.6 customer support and mobile app capabilities.4.3 varies by type of transaction; other fees may apply though you'll have to pay for some of its optional services trading crypto carries a fee of about 0.5% per transaction And buying or selling cryptocurrency with fiat currency will cost you about 2% You'll also pay fees assessed by the blockchain networks that support your cryptocurrency and these can vary significantly depending on market conditions and which asset you're using Guarda notes that these fees go not to its creators but to the third-party partners it works with There's no readily available explanation on Guarda's website for how the company makes money If you're looking to store a wide variety of cryptocurrencies across multiple devices NerdWallet's comprehensive review process evaluates and ranks products that allow U.S. customers to store, send and receive cryptocurrency. We aim to provide our independent assessment of providers to help arm you with information to make sound, informed judgments on which will best meet your needs. We adhere to strict guidelines for editorial integrity. We conduct firsthand testing and observation and the results fuel our proprietary assessment process that scores each provider's performance across more than 15 factors The final output produces star ratings from poor (1 star) to excellent (5 stars) For more details about the categories considered when rating wallets and our process, read our full methodology. Helpful resources Colossal and birds through a digital process that’s taken years to develop See more behind-the-scenes images documenting both the printing techniques and final presentation on Ferrer’s Instagram. (via Kottke) Do stories and artists like this matter to you? Become a Colossal Member now Join more than 200,000 subscribers and get the best of art and visual culture from Colossal Copyright © 2025 Colossal. See our Terms of Service and Privacy Policy Save The Waves recently returned to Guarda do Embaú in Brazil to meet with the Local Stewardship Council of the ninth World Surfing Reserve Conservation Programs Manager Trent Hodges checked in on the progress of the stewardship planning conservation projects and the dedication on October 25-27th Surf ecosystems are integrated natural and social systems embodying the special relationship between the ocean It’s all interconnected.Take a look at the Guarda do Embaú World Surfing Reserve The coast and surrounding lands are a biodiversity hotspot it contains crucial geophysical factors that contribute to the surf and it has a strong local culture that values surfing and marine resources The world class waves are shaped and cultivated by the Rio do Madre River whose waters flow down from the mountains in the Serra do Tabuleiro State Park The fluvial sediment provided by the river creates a series of shifting sand dunes that contribute to waves up and down the beach around Guarda The ancient tradition of tainha fishing not only supports the local fishermen it is a strong foundation of community bonding everyone from the community joins the fishermen in pulling the nets from the ocean harvesting the bounty and celebrating the catch Surf culture has permeated Guarda and is both a beloved part of the social fabric and a beneficial aspect of the local economy Guarda hosts several surf competitions and has raised world-class surfers such as Jacqueline Silva and the late Ricardo dos Santos riparian river habitat and vast swaths of Atlantic rainforest make Guarda home to many unique and threatened plant and animal species The Guarda do Embaú World Surfing Reserve requires active conservation strategies to ensure this thriving surf ecosystem remains intact.Support our global conservation efforts and make a donation today Donate today and make a global impact for our coastlines repelling threats – the slo-mo smarts of slime mouldsSaveTo the naked eye the organism Physarum polycephalum – commonly referred to as ‘slime mould’ – might seem an unexceptional creature as its acellular existence is dedicated to tracking nutrients at a speed of 1mm per hour But this protist’s surprising computational cunning becomes apparent when viewed in time-lapse revealing a life form that seems to possess intelligence despite lacking a nervous system the UK artist and researcher Heather Barnett conducted a series of clever experiments in which she probed slime moulds’ capacities for forming complex tube networks and adjusting to obstacles Aeon Video compiled Barnett’s ‘creative collaborations’ with P polycephalum into a montage that builds in complexity emphasising the slime moulds’ surprisingly sophisticated capacities for problem-solving Director: Heather Barnett EmailSavePostShareSavevideo Do button-pushing dogs have something new to say about language? Savevideo Ideas ‘of pure genius’ – how astronomers have measured the Universe across history Savevideo Why a single tree, uprooted in a typhoon, means so much to one man in Hanoi ‘I want me back’ – after a head injury, Nick struggles with his altered reality Why Orwell urged his readers to celebrate the spring, cynics be damned Savevideo On the Norwegian coast, a tree is transformed into a boat the old-fashioned way One man’s quest to save an orphaned squirrel, as narrated by David Attenborough A future in which ‘artificial scientists’ make discoveries may not be far away Savevideo Children of the Rwandan genocide face a unique stigma 30 years later Metrics details Sickle cell anemia (SCA) is a hemolytic disease in which vaso-occlusion is an important pathophysiological mechanism The treatment is based on hydroxyurea (HU) which decreases leukocyte counts and increases fetal hemoglobin synthesis Different cell types are thought to contribute to vaso-occlusion the role of monocytes subsets remains unclear We investigated frequencies of monocytes subsets in blood and their response to HU therapy testing their ability to express pro-inflammatory molecules and tissue factor (TF) We identified major changes in monocyte subsets with classical monocytes (CD14++CD16−) appearing highly frequent in who were not taking HU whereas those with patrolling phenotype (CD14dimCD16+) were enriched in individuals undergoing therapy IL-8 as well as TF by the LPS-activated monocytes frequency of TF-expressing monocytes is increased in patients with previous vaso-occlusion activated monocytes expressing TF produced several pro-inflammatory cytokines simultaneously Such polyfunctional capacity was dramatically dampened by HU therapy The frequency of classical monocytes subset was positively correlated with percentage cytokine producing cells upon LPS stimulation These findings suggest that classical monocytes are the subset responsible for multiple pro-inflammatory cytokine production and possibly drive inflammation and vaso-occlusion in SCA which is damped by HU Understanding the mechanisms driving susceptibility to VOE is critical to develop optimization of clinical management and development of new therapeutic approaches of SCA patients The exact mechanisms by which TF-expressing monocytes may drive VOE and/or cardiovascular complications of SCA patients are not completely described Considering the intricate mechanisms related to SCA pathogenesis we aimed to investigate in detail the effect of HU therapy on circulating monocytes subsets and on their ability to express TF as well as pro-inflammatory cytokines upon activation in SCA patients we tested association between monocyte activation phenotypes and occurrence of VOE Our findings indicate that HU therapy induces substantial changes in frequency of monocyte subsets as well as in their capacity to promote inflammation and coagulation which was associated to occurrence of VOE in SCA our data suggest that HU treatment modulate the inflammatory response driven by the monocytes The two patients underoing HU therapy experienced one episode of VOE six months prior to blood drawn and referred HU use for the last 6 years (C) Frequencies of indicated monocyte subsets PBMC between the study groups were compared using the Mann-Whitney U test Hydroxyurea therapy negatively impacts production of pro-inflammatory cytokines of monocytes in response to LPS PBMC from sickle cell anemia patients were incubated with 100 ng/mL LPS in vitro and intracellular cytokine staining assay was performed to test whether hydroxyurea treatment in vivo induces changes in the capacity of monocytes to respond to LPS by producing TNF-α the study groups were compared using the Mann-Whitney U test Sickle cell anemia-associated tissue factor production by monocytes in response to LPS is diminished by hydroxyurea treatment in vivo (A) PBMC from sickle cell anemia patients were incubated with 100 ng/mL LPS in vitro and intracellular cytokine staining assay was performed to test whether hydroxyurea treatment in vivo induces changes in the capacity of monocytes to respond to LPS by producing tissue factor (TF) HU group n = 17 and no HU group n = 20 At each experimental condition (B) Mean Fluorescence Intensity (MFI) of TF expression by monocytes at indicated experimental conditions is shown No statistically significant differences were observed (C) Frequency of TF-expressing monocytes upon LPS stimulation was compared between SCA patients presenting or not previous occurrence of vaso-occlusive events (VOE) The study groups were compared using the Mann-Whitney U test (D) Receiver Operator Characteristics (ROC) curve analyses was employed to test whether frequency of TF-expressing monocytes after LPS stimulation could discriminate patients with previous occurrence of VOE from those who had not as a way to measure strength of association (E) Frequencies of TF-expressing monocyte subsets was compared were compared between the indicated groups using the Mann-Whitney U test These results uncover differential ability to induce TF expression among the distinct subsets of monocytes in SCA patients Hydroxyurea therapy reduces the capacity of activated monocytes to produce multiple pro-inflammatory cytokines Polyfunctional analysis of TF− (A) and TF+ (B) monocytes upon LPS stimulation was performed in PBMC from SCA patients undertaking or not hydroxyurea Data were compared using the Mann-Whitney U test (C) The overall cytokine expression profiles of activated TF− or TF+ monocytes from SCA patients treated or not with hydroxyurea were compared using the chi-square test (D) Frequencies of monocytes producing more than 1 cytokine in vitro were compared between SCA patients undertaking (n = 17) or not (n = 20) hydroxyurea using the Mann-Whitney U test Ex vivo frequency of CD14++CD16− monocytes in peripheral blood directly correlates with the capacity of activated monocytes to produce pro-inflammatory cytokines (A) Frequencies of classical monocytes in peripheral blood from SCA patients undertaking or not hydroxyurea were tested for correlations with frequencies of monocytes expressing indicated markers after LPS stimulation in vitro Data were compared using the Spearman correlation rank test (B) Spearman correlations between frequency of monocytes subsets and frequency of monocytes expressing IL-1 β Bars represent the strength of correlation (r values) Red bar indicates statistically significant correlation (p < 0.05 after adjustment for multiple comparisons) while grey bars were nonsignificant We hypothesize that HU may directly induce differentiation of classical monocytes into non-classical/patrolling phenotype by increasing CD16 expression Future studies are warranted to answer this question Considering that heme is released during hemolysis these findings argue that intravascular hemolysis may play a pivotal role in monocyte activation in SCA these data indicate that HU affects not only monocyte subsets but also the ability of these cells to produce pro-inflammatory cytokines In sterile inflammatory conditions such as SCA the polyfunctionality still remains to be evaluated we investigated the cytokine profile production of both TF+ and TF− monocytes and also tested the effect of HU in production of multiple pro-inflammatory cytokines Our data provide evidence that patients who were not under HU therapy have increased frequency of monocytes simultaneously producing TF HU substantially dampened such production without affecting cell death This result suggests that the inflammatory response promoted by activated monocytes relies on the production of multiple pro-inflammatory cytokines and is directly affected by HU therapy this is the first study to determine ex vivo characterization of monocytes subsets and to identify their polyfunctionality in SCA the association between TF-expressing monocytes and occurrence of VOE also highlights the importance of these cells in vascular complications linked to SCA our data corroborate with previous studies that show beneficial effects of HU therapy in SCA We show that HU is associated with the improvement of laboratory parameters to decreased frequency and activation of the classical inflammatory monocytes HU therapy directly dampened the polyfunctional capacity of monocytes suggesting an overall anti-inflammatory property which the molecular mechanism still requires elucidation Considerations regarding monocytes subsets activation profile and cytokine production are useful to suggest novel therapeutic targets and may help to understand the inflammatory mechanism underlying SCA Thirty-seven pediatric SCA patients (HbSS genotype) were enrolled in the present study all seen at the Bahia Hemotherapy and Hematology Foundation from August 2017 to December 2017 The patients had an average age of 14.16 ± 3.08 years and a median age of 14 years (interquartile range [IQR]: 12–17 years) All patients were in steady state of sickle cell anemia characterized as the absence of acute crisis in the past three months prior to blood collection procedures Three patients have had stroke and were under blood transfusion therapy; one patient had received transfusion 10 months before study enrollment and the other two had received 30 days before enrollment Twenty patients were not under HU therapy while 17 patients were taking HU for at least 5 months Prior to enrollment in the study informed consent was obtained from all individual participants Legal guardians agreed to allow the biological sample collection procedures and signed terms of informed consent of all individuals under 18 years while individuals older than 18 years have signed the assent form This study received approval from the Institutional Research Board of São Rafael Hospital (protocol number: 1400535) and is in compliance with the ethical principles of the revised Declaration of Helsinki clinical data regarding the occurrence of previous clinical manifestations (e.g VOE) were collected using a standardized questionnaire (self-reported or reported by the parents) and confirmed by the medical records Patients or their legal guardians were asked whether they ever had or not Hospital admissions were defined as hospitalization for more than three days and VOE were defined as acute pain affecting any body part lasting several hours in association with swelling especially in the joints and soft tissues requiring medication Patients with previous history of VOE presented at least one episode of VOE (ranging from 1 to 5 events) in the past six months Hematological parameters were obtained using a Beckman Coulter LH 780 Hematology Analyzer (Beckman Coulter USA) and hemoglobin patterns were confirmed by high-performance liquid chromatography employing an HPLC/Variant-II hemoglobin testing system (Bio-Rad hepatic metabolism and renal profile were determined using an automated A25 chemistry analyzer (Biosystems S.A Ferritin levels were determined using Access 2 Immunochemistry System (Beckman Coulter Inc. C-reactive protein and alpha-1 antitrypsin levels were measured using IMMAGE® Immunochemistry System (Beckman Coulter Inc. Laboratory parameters were analyzed at the Clinical Analyses Laboratory of the College of Pharmaceutical Sciences (Universidade Federal da Bahia) Antibodies dilutions were carried out according to each manufacturer’s instructions and validated in titration experiments Acquisition of the stained cells was performed using a BD LSRFortessa™ cell analyzer (BD Bioscience after correction for multiple measurements using the Holm-Bonferroni method were considered statistically significant Kato, G. J. et al. Sickle cell disease. Nature reviews. Disease primers 4, 18010, https://doi.org/10.1038/nrdp.2018.10 (2018) Guarda, C. C. D. et al. Heme-mediated cell activation: the inflammatory puzzle of sickle cell anemia. Expert review of hematology 10, 533–541, https://doi.org/10.1080/17474086.2017.1327809 (2017) Manwani, D. & Frenette, P. S. Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies. Blood 122, 3892–3898, https://doi.org/10.1182/blood-2013-05-498311 (2013) Henson, P. M. & Hume, D. A. Apoptotic cell removal in development and tissue homeostasis. Trends in immunology 27, 244–250, https://doi.org/10.1016/j.it.2006.03.005 (2006) Kratofil, R. M., Kubes, P. & Deniset, J. F. Monocyte Conversion During Inflammation and Injury. Arteriosclerosis, thrombosis, and vascular biology 37, 35–42, https://doi.org/10.1161/ATVBAHA.116.308198 (2017) Ingersoll, M. A., Platt, A. M., Potteaux, S. & Randolph, G. J. Monocyte trafficking in acute and chronic inflammation. Trends in immunology 32, 470–477, https://doi.org/10.1016/j.it.2011.05.001 (2011) Boyette, L. B. et al. Phenotype, function, and differentiation potential of human monocyte subsets. PloS one 12, e0176460, https://doi.org/10.1371/journal.pone.0176460 (2017) Heterogeneity of human peripheral blood monocyte subsets Schechter, M. E. et al. Inflammatory monocytes expressing tissue factor drive SIV and HIV coagulopathy. Science translational medicine 9, https://doi.org/10.1126/scitranslmed.aam5441 (2017) Andrade, B. B. et al. Mycobacterial antigen driven activation of CD14++CD16- monocytes is a predictor of tuberculosis-associated immune reconstitution inflammatory syndrome. PLoS pathogens 10, e1004433, https://doi.org/10.1371/journal.ppat.1004433 (2014) Woollard, K. J. & Geissmann, F. Monocytes in atherosclerosis: subsets and functions. Nature reviews. Cardiology 7, 77–86, https://doi.org/10.1038/nrcardio.2009.228 (2010) Nahrendorf, M., Pittet, M. J. & Swirski, F. K. Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation 121, 2437–2445, https://doi.org/10.1161/CIRCULATIONAHA.109.916346 (2010) Activated monocytes in sickle cell disease: potential role in the activation of vascular endothelium and vaso-occlusion Safaya, S., Steinberg, M. H. & Klings, E. S. Monocytes from sickle cell disease patients induce differential pulmonary endothelial gene expression via activation of NF-kappaB signaling pathway. Molecular immunology 50, 117–123, https://doi.org/10.1016/j.molimm.2011.12.012 (2012) Carvalho, M. O. S. et al. Inflammatory mediators in sickle cell anaemia highlight the difference between steady state and crisis in paediatric patients. British journal of haematology, https://doi.org/10.1111/bjh.14896 (2017) Brittain, J. E. & Parise, L. V. Cytokines and plasma factors in sickle cell disease. Current opinion in hematology 14, 438–443, https://doi.org/10.1097/MOH.0b013e3282a4a673 (2007) Cajado, C. et al. TNF-alpha and IL-8: serum levels and gene polymorphisms (−308G>A and −251A>T) are associated with classical biomarkers and medical history in children with sickle cell anemia. Cytokine 56, 312–317, https://doi.org/10.1016/j.cyto.2011.07.002 (2011) Lanaro, C. et al. Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy. Journal of leukocyte biology 85, 235–242, https://doi.org/10.1189/jlb.0708445 (2009) Spronk, H. M., ten Cate, H. & van der Meijden, P. E. Differential roles of tissue factor and phosphatidylserine in activation of coagulation. Thrombosis research 133(Suppl 1), S54–56, https://doi.org/10.1016/j.thromres.2014.03.022 (2014) Setty, B. N. et al. Tissue factor-positive monocytes in children with sickle cell disease: correlation with biomarkers of haemolysis. British journal of haematology 157, 370–380, https://doi.org/10.1111/j.1365-2141.2012.09065.x (2012) Solovey, A., Gui, L., Key, N. S. & Hebbel, R. P. Tissue factor expression by endothelial cells in sickle cell anemia. The Journal of clinical investigation 101, 1899–1904, https://doi.org/10.1172/JCI1932 (1998) Steinberg, M. H. et al. Effect of hydroxyurea on mortality and morbidity in adult sickle cell anemia: risks and benefits up to 9 years of treatment. Jama 289, 1645–1651, https://doi.org/10.1001/jama.289.13.1645 (2003) Clinical utility of a myelosuppressive “switching” agent The Multicenter Study of Hydroxyurea in Sickle Cell Anemia Rodgers, G. P., Dover, G. J., Noguchi, C. T., Schechter, A. N. & Nienhuis, A. W. Hematologic responses of patients with sickle cell disease to treatment with hydroxyurea. The New England journal of medicine 322, 1037–1045, https://doi.org/10.1056/NEJM199004123221504 (1990) Yahouédéhou, S. C. M. A. et al. Sickle Cell Anemia Patients in Use of Hydroxyurea: Association between Polymorphisms in Genes Encoding Metabolizing Drug Enzymes and Laboratory Parameters. Disease Markers 2018, 11, https://doi.org/10.1155/2018/6105691 (2018) Hydroxycarbamide in very young children with sickle-cell anaemia: a multicentre Singhal, R. et al. Development of pro-inflammatory phenotype in monocytes after engulfing Hb-activated platelets in hemolytic disorders. Clin Immunol 175, 133–142, https://doi.org/10.1016/j.clim.2016.12.007 (2017) Monocyte Shift to a Non-Classical CD14dim/CD16+ Phenotype Correlates with Fetal Hemoglobin Levels in Sickle Cell Anemia Patients Treated with Hydroxyurea Figueiredo, R. T. et al. Characterization of heme as activator of Toll-like receptor 4. The Journal of biological chemistry 282, 20221–20229, https://doi.org/10.1074/jbc.M610737200 (2007) Kim, S. et al. Signaling of high mobility group box 1 (HMGB1) through toll-like receptor 4 in macrophages requires CD14. Mol Med 19, 88–98, https://doi.org/10.2119/molmed.2012.00306 (2013) Akbarshahi, H. et al. TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated. Journal of translational medicine 9, 219, https://doi.org/10.1186/1479-5876-9-219 (2011) Solovey, A. et al. A monocyte-TNF-endothelial activation axis in sickle transgenic mice: Therapeutic benefit from TNF blockade. American journal of hematology 92, 1119–1130, https://doi.org/10.1002/ajh.24856 (2017) Penkert, R. R. et al. Inflammatory molecule reduction with hydroxyurea therapy in children with sickle cell anemia. Haematologica 103, e50–e54, https://doi.org/10.3324/haematol.2017.177360 (2018) Liu, Y. et al. HO-1(hi) patrolling monocytes protect against vaso-occlusion in sickle cell disease. Blood 131, 1600–1610, https://doi.org/10.1182/blood-2017-12-819870 (2018) Keikhaei, B. et al. Altered levels of pro-inflammatory cytokines in sickle cell disease patients during vaso-occlusive crises and the steady state condition. European cytokine network 24, 45–52, https://doi.org/10.1684/ecn.2013.0328 (2013) Bandeira, I. C. et al. Chronic inflammatory state in sickle cell anemia patients is associated with HBB(*)S haplotype. Cytokine 65, 217–221, https://doi.org/10.1016/j.cyto.2013.10.009 (2014) Dagur, P. K. et al. Haem augments and iron chelation decreases toll-like receptor 4 mediated inflammation in monocytes from sickle cell patients. British journal of haematology 181, 552–554, https://doi.org/10.1111/bjh.14663 (2018) Ito, T. PAMPs and DAMPs as triggers for DIC. Journal of intensive care 2, 67, https://doi.org/10.1186/s40560-014-0065-0 (2014) Belcher, J. D. et al. Heme triggers TLR4 signaling leading to endothelial cell activation and vaso-occlusion in murine sickle cell disease. Blood 123, 377–390, https://doi.org/10.1182/blood-2013-04-495887 (2014) Shet, A. S. et al. Sickle blood contains tissue factor-positive microparticles derived from endothelial cells and monocytes. Blood 102, 2678–2683, https://doi.org/10.1182/blood-2003-03-0693 (2003) Colella, M. P. et al. Hydroxyurea is associated with reductions in hypercoagulability markers in sickle cell anemia. Journal of thrombosis and haemostasis: JTH 10, 1967–1970, https://doi.org/10.1111/j.1538-7836.2012.04861.x (2012) Soliman, M. & Ragab, S. Tissue factor-positive monocytes in children with sickle cell disease: relation to vaso-occlusive crisis. The Egyptian Journal of Haematology 40, 177–184, https://doi.org/10.4103/1110-1067.170203 (2015) Selimoglu-Buet, D. et al. Accumulation of classical monocytes defines a subgroup of MDS that frequently evolves into CMML. Blood 130, 832–835, https://doi.org/10.1182/blood-2017-04-779579 (2017) Hsiao, H. M. et al. Spleen-derived classical monocytes mediate lung ischemia-reperfusion injury through IL-1beta. The Journal of clinical investigation, https://doi.org/10.1172/JCI98436 (2018) Chardin, P., McCormick, F. & Brefeldin, A. the advantage of being uncompetitive. Cell 97, 153–155, https://doi.org/10.1016/s0092-8674(00)80724-2 (1999) Mollenhauer, H. H., Morre, D. J. & Rowe, L. D. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity. Biochimica et biophysica acta 1031, 225–246, https://doi.org/10.1016/0304-4157(90)90008-z (1990) Download references we would like to thank to all the SCA patients involved in this study We also would like to thank to MD Larissa Carneiro Rocha and all the staff at the Bahia Hemotherapy and Hematology Foundation for the valuable help with the sample collect the authors thank Drs Kiyoshi Fukutani and Artur Queiroz (Fundação Oswaldo Cruz Brazil) for revising the statistical analyses CCG received a scholarship from CNPq and PSMSM received scholarship from FAPESB B.B.A and MSG have productivity scholarship from CNPq The work from BBA was supported by the National Institutes of Health (U01AI115940) The work from MSG was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq 470959/2014-2 and 405595/2016-6) Laboratório de Investigação em Genética e Hematologia Translacional Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative Fundação de Hematologia e Hemoterapia do Estado da Bahia (HEMOBA) Salvador Escola Bahiana de Medicina e Saúde Pública designed and performed all the experiments and co-wrote the manuscript collected all the samples and performed the laboratory characterization conceptualized and supervised the study and critically revised the manuscript The authors declare no competing interests Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41598-019-51339-x Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology Nitika Choraria Nitika is a design writer who graduated in Digital Management from Istituto Marangoni Milano For her - design is a boundless medium of self-expression that encapsulates a balance between functionality and aesthetics Amalia Puga Amalia Puga presents ‘Entre Redes’ – an extraordinary collection rooted in the community of A Guarda shedding light on their significant traditions of the art of net making carried out by a group of women known as the “redeiras”.  Beautifully designed to narrate stories – her eclectic work effortlessly creates an impact on people’s perception as well as behavior Implementing local collaborative solutions, Puga truly enjoys experimenting with materials, harmoniously combining new and traditional techniques to brilliantly craft sustainable products She feels especially connected to her place of birth a small fishing village near the Portuguese coast where – throughout history work between women has been essential for the economic growth of the town “Is it possible to blend craftsmanship and design to help keep the tradition of a small fishing village alive? How can we collaborate to empower women who fight for the future of their work? – Following this thought  Entre Redes was born” says Puga. Seamlessly incorporating the “redeiras” of A Guarda in the design process of a collection of objects – she gracefully fuses the individuality of their artisan techniques with the possibility of innovation.  The resulting products, Bolina and Saia, are deeply inspired by marine objects and tools, handmade with recycled nets from the sea and woven with traditional fishing knots utilized by the netmakers throughout history.  At first, Bolina skillfully incorporates unused fishing rope pieces from the process of net making.  Handwoven by the local women netmakers of A Guarda – this one-of-a-kind chair is entirely joined by traditional fishing knots, leading to an innovative reinterpretation of the technique, yet maintaining the identity of the craft. Every week, get to know the most interesting Design trends & innovations © 2022 DesignWanted S.r.l. (Innovative StartUp) Registered office: Via Aurelio Saffi 29, 20123 Milan (Italy)  |  VAT no.: 10565330965  |  ROC no.: 36152  |  REA no.: MI-2541466  |  Share capital: 12.540€ © Fernando Guerra | FG+SGA physical presence that is diluted in its condition as “part of the city” and “object” It is the reproduction of a formal image that translates into an intrinsic autonomy for each production The buildings construct a tectonic dependence on the site with a desire to reveal their formal specific character based on their own content Facing material consists of glass-fibre reinforced concrete panels (GRC) There was a risk of trying to design and compose the plastic elements in a way as to eliminate a single constructed mass The objective was to create diverse stage forms and spaces intrinsically compelling the spectator to adopt an inter-relational and heterogeneous posture You'll now receive updates based on what you follow Personalize your stream and start following your favorite authors If you have done all of this and still can't find the email Don’t miss the latest drinks industry news and insights Sign up for our award-winning newsletters and get insider intel and trends delivered to your inbox every week Cava announced plans to make all Cava de Guarda Superior 100 percent organic by 2025 what does this major step mean for the region At a moment of widespread greenwashing in the wine world, when it’s all too common for brands and organizations alike to pay lip service to sustainability without implementing actual change, D.O. Cava is taking concrete steps toward solving the myriad problems the industry faces today This much has been apparent since April 2021 Cava announced a series of sweeping regulation changes concerning the production of Cava de Guarda Superior this elite category includes the specific designations of Cava Reserva (with a minimum of 18 months of bottle aging) and Cavas de Paraje Calificado (Cavas sourced from specific single-vineyard plots and aged a minimum of 36 months) which the denomination described as “the most exacting standards in the world for quality D.O sparkling wines made using the strict traditional method,” all grapes destined for the Guarda Superior designation must be hand-harvested from vineyards with a minimum of 10 years of age In addition to strictly limiting yields (to a maximum of 4.9 tons per acre) and requiring vintage and disgorgement dates for all Guarda Superior wines Cava also requires estates to comply with strict traceability audits from harvest to bottle It would save its most radical update for last declaring a commitment to convert all Cava de Guarda Superior to 100 percent organic by 2025 To the region’s faithful legions of growers and producers this watershed decision aligns with a wider effort to strengthen Cava’s qualitative foundations while ensuring a more sustainable future for the territory where world-class traditional method wines have been crafted for more than a century estates both large and small are busy putting plans in place to adapt to this ambitious new mandate Such a massive paradigm shift cannot help but invite questions and bring a certain set of challenges With the 2025 deadline quickly approaching what are the implications for the style and quality of Cava as well as its long-term growth and distribution And how will overcoming the short-term hurdles involved in reaching this milestone help to ensure the enduring success of Spain’s most famous and historically celebrated sparkling wine As extraordinary as D.O. Cava’s decision might seem, in many ways it represents the natural extension—and official formalization—of an evolution that had already been brewing for quite some time. Over recent years, the denomination has staked its claim as a global pioneer of organic viticulture. According to its 2022 Global Report the annual number of bottles of Cava labeled as organic has grown by more than 40 percent compared to 2021 this transformation will only accelerate as Cava continues to lead the push toward more resilient forms of agriculture “The number of bottles of organic Cava produced has now reached 13,780,711 units 34.09 percent of which corresponds to premium organic Cava.” Cava’s considerable effort in promoting organic production Pagés stresses that “both the consumer and the market are demanding it.” Ultimately he views this evolution as being driven by deeper currents than market forces alone; he believes it amounts to an act of conservation for the territory itself “This care and preservation of the territory is something with which we identify closely.” “The region’s relatively low disease pressure and sufficient sunlight support the growth of healthy vines with fewer chemical interventions.”  Despite these natural advantages, the exacting standards the D.O. established to track compliance, requiring estates to trace every step of the production process from vineyard to bottle, still presents a challenge for some winemakers. “The process is extremely difficult to manage if you’re not used to it,” says Marta Casas, a winemaker and co-owner at Parés Baltà the pioneering organic estate that first gained certification in 2003 before converting to biodynamic in 2013 “Even for us it has been a significant challenge and we’ve been farming organically since 2003.” the end results more than compensate for all the hard work their efforts will preserve the land for future generations their work takes a critical step toward defining Cava both as a world-class sparkling wine and a unique expression of place “It’s a big change in terms of the mentality of the producers but in the end it will present us with an equally big reward,” says Casas These changes will allow us to demonstrate to the consumer that our Cava comes from a very specific part of the world and that each step of the process is controlled and verified from the very beginning.” it’s still too early to predict how these major shifts at the level of production will impact the sales and distribution of Cava’s top wines in the global market Buyers and consumers alike can expect what Aura calls “the introduction of a dynamic dimension to production and distribution.”  “pricing in the market might reflect the additional effort and cost associated with organic farming.” Any such realignment would simply represent a fair-market adjustment helping to “position Cava de Guarda Superior as a premium product that aligns with consumer preferences for sustainable and high-quality wines.” To Maite Esteves, a partner and the manager of Vins El Cep another pioneer of organic sparkling wine in Comtats de Barcelona the revolutionary changes taking place within Cava’s top tier ultimately promise to reinvigorate the category as a whole “The most important thing is that all this means a change for the entire sector and that it serves to improve the positioning of Cava,” she says “The future of Cava depends on increasing its value so that the entire chain is strong and committed to quality.”  While it’s impossible to see into the future one thing’s for certain: We don’t need to wait until 2025 to taste the results Armed with a new story to tell about itself and the passionate artisans who make it the denomination’s highly anticipated transformation is already underway Don’t miss the latest drinks industry news and insights—delivered to your inbox every week winemaker Nicole Marchesi has helped usher Far Niente into the future while honoring the legendary winery’s roots PDO Santorini’s distinctive volcanic terroir the exceptional qualities of its Assyrtiko grapes and the unique vine-growing methods employed by its winemakers all contribute to the unparalleled character of its wines Italian icon Florio has both pioneered and perfected the famous fortified wine in the town of Marsala Far Niente Wine Estates has built a portfolio of emblematic Napa Valley Cabernet Sauvignons at every price point Learn more about how Provi simplifies the complex process of ordering and promoting wholesale alcohol between buyers SevenFifty Daily is an award-winning online magazine about the business and culture of the beverage alcohol industry covering all three tiers of the alcohol industry Joe: You're a child He's the moon when I'm lost in darkness and warmth when I shiver in cold His heart overflows with the kindness of which this world is not worth of Nicky: You're an incurable romantic. [Joe and Nicky kiss in front of the stunned guards] Your Ads Privacy ChoicesIMDb I Massacre hanno pubblicato il video ufficiale di ‘Death May Die’ nuovo singolo tratto dall’album “Necrolution” in uscita il prossimo 8 novembre per Agonia Records “Necrolution” is a retrospective that turns back time to the late 80s and early 90s era of death metal Recapturing the essence and style of death metal that was the original formula Recreating the aesthetic feeling of something from the original style and sound to represent to these modern times It’s purposefully meant to sound dated as it represents an era of early death metal music It purposefully does not mimic the band’s own original style but rather reflects the styles of many early era bands that influenced generations in death metal music Commented by Kam Lee: “With «Necrolution» the idea was to evolve the band’s sound by devolving it Unlike many bands in death metal that attempt to modernize and update their style and sound to emulate many of the modern contemporary death metal bands We wanted to make an album that sounds like it could have come out of the late 80s The entire concept was to create something that was a de-evolution of the death metal genre and go back to an early style reminiscent of the past Going back 40 years into the past to immolate the style of death metal that was predominantly influenced by thrash and heavy metal bands of the era Lyrically it’s still entrenched in the horror genre and influenced by HP Lovecraft stories We even have three tracks directly dedicated and influenced by the director Stewart Gordon the filmmaker who was directly responsible for bringing Lovecraft films to horror movies in the 80s The overall idea was to bring a 1980s aesthetic to the music that’s influenced by 1980s music as well as horror movie genre at the time My hope is that fans find a unique experience when listening to «Necrolution» that not only encapsulates the feeling of 80s nostalgia but makes them appreciate the way the era influenced the death metal genre at the time.” “Necrolution” was recorded at DOA studios Full S Studios & Gojiden Studio in Florida (USA) and mixed and mastered by Jonny Pettersson at Studio Unbound in Sweden The cover artwork was painted by Timbul Cahyono of Bvllmetalart Morbid Angel) created the merchandise designs The recording personnel for the new album – much of whom have been with MASSACRE since the “Resurgence” era – comprises returning guitarists Rogga Johansson (Paganizer Megascavanger) & Jonny Pettersson (Wombbath The band features a separate session line-up for live performances which consists of Carlos Gonzalez (Grim Reality) on guitars Elden Santos (Druid Lord) on drums and Tim Wilson on bass MASSACRE started out as a heavy/power metal band but changed its style to death metal with the joining of Allen West and Kam Lee; the latter is often credited for inventing the “death growl” – first heard on the band’s 1986 demo “Aggressive Tyrant” – and is considered an influential pioneer as far as the death metal genre is concerned The group went through several personnel shifts and disbandments over the years – with its early line-up toggling between MASSACRE Mantas (early Death) and Death – to a triumphant return in 2021 with their last studio album “Resurgence” Photo credit: Alayna B. Lee; bigger photo: click Pre-orders:https://massacre.agoniarecords.com/