Ground has been broken for the Ribeirão Preto Brazil Temple one of the 23 total temples of The Church of Jesus Christ of Latter-day Saints that are dedicated under construction or in planning for South America’s largest nation Elder Joni L. Koch a General Authority Seventy and president of the Brazil Area offering remarks and a prayer dedicating the site and construction process Approximately 500 people attended the event including local Church leaders and members civic and community representatives and leaders of other faiths Elder Koch spoke of serving as a full-time missionary in Ribeirão Preto 44 years earlier and being welcomed by many local Latter-day Saints He called on one of the family members — Marcia Ginatto Constante who served with her husband on the groundbreaking committee and was a young woman when Elder Koch served in her city — to share her testimony “My people were part of the growth of the Church,” she said “Many who have already passed away worked so this temple could be built What a blessing to be part of the Lord’s kingdom and see His house being built here This work is moving forward for the coming of Christ.” Elder Koch offered words of reverence and gratitude to Heavenly Father for the Savior Jesus Christ “We give thanks to Thee for having sent Thy Son Jesus Christ to earth restored Church and covenants enable us to return to Thy presence,” he prayed He also paid tribute to the early and longtime Latter-day Saints in the Ribeirão Preto area in the southeast region of Brazil “We remember with appreciation those who were the first members of the Church in this region,” he said “The example of these pioneers has been a moral and spiritual support for Thy kingdom to flourish from these few who stood firm so that thousands of Latter-day Saints could on this day — here in this part of the earth — enjoy this sublime moment.” The ceremony took place under clear-blue skies with other local members participating in the ceremony and a video in Portuguese available of the event Marly Pimenta Vecchi of the Ribeirão Preto Sul Stake, who has been a Church member for almost 70 years, recalled the importance of the house of the Lord in her life and that of her family, including her sealing in the São Paulo Brazil Temple after its dedication in 1978 When a temple was announced for Ribeirão Preto she recalled that “the feeling of gratitude came over all of us I am so grateful that God has preserved me to see the growth of the Church in this region and that I can participate in this occasion knowing that so many people will be blessed as I was.” Arthur Neres de Lira Azevedo spoke of performing proxy baptisms for his grandparents in the Campinas Brazil Temple “I was so happy when I heard that a temple would be built so close to our homes where we can go more often,” the young man said “I know we can trust in Jesus Christ and the comfort we have from him And 15-year-old Hector Moreno Benavides of the Ribeirão Preto Leste Stake ssaid: “The temple is the most sacred place on earth and we have the privilege of feeling closer to Jesus Christ The Lord is in the temple; we don’t see Him Less than two months later, a site for the house of the Lord was released Planned as a single-story temple of approximately 32,000 square feet the Ribeirão Preto Brazil Temple will be built at Avenida Antônio Marçal and Rua José Brandani in Ribeirão Preto An exterior rendering of the temple was published earlier this year 2022 announcement for temples in Ribeirão Preto and Londrina the planning and progression of the two houses of the Lord have proceeded almost in step with each other – from site announcement to exterior rendering release to groundbreaking The Londrina Brazil Temple will have its groundbreaking on Aug. 17, one of three temples scheduled that day, along with the Austin Texas and Santiago West Chile temples The Church makes every effort to construct temples in an expeditious manner various reasons may delay a temple’s completion and dedication Located in southeastern Brazil and with a metro-area population of nearly 1.7 million people Ribeirão Preto is in the northeastern region of the state of São Paulo about 313 kilometers from the state capital of São Paulo Ribeirão Preto dates back to 1856 and is named for the black creek or black stream by which it was built The fertile soil of the area fostered the city’s deep roots in agriculture and farming Nearly 1.5 million Latter-day Saints in more than 2,170 congregations reside in Brazil with missionary work and Church operations dating back to 1928 The Book of Mormon was translated and published in Portuguese in 1940 helping spark a new era of growth in Brazil Brazil is home to 23 total temples dedicated, under construction or announced, including the São Paulo Brazil Temple the first not only in Brazil but across all of South America when it was dedicated in 1978 The temple in Belo Horizonte has been under construction since June 2023 and is now joined by the future house of the Lord in Ribeirão Preto Ribeirão Preto is in the Campinas Brazil Temple district a distance of about 230 kilometers (143 miles) and a drive of at least three hours Metrics details the prevalence of mental disorders is heterogeneous with most studies conducted in large cities with high population density This study aimed to assess the prevalence of mental disorders and psychiatric comorbidities among young adults (22–23 years old) and adults (37–38 years old) from Ribeirão Preto a city located in the Northeast of the São Paulo state and to explore associations with sociodemographic variables we aimed to evaluate the performance of the Self-Report Questionnaire (SRQ-20) as a screening tool for mental disorders to be applied to the local population Participants from the 1978/1979 and 1994 Ribeirão Preto birth cohorts were evaluated using the Mini International Neuropsychiatric Interview (MINI) and the SRQ-20 at mean ages of 22–23 Our sample comprised 1,769 individuals from the 1978/1979 cohort and 1,037 from the 1994 cohort The prevalence of mental disorders ranged from 28.6% (1978/79) to 31% (1994) with frequent comorbid diagnoses (42.7% and 43.3% Men and women had a similar prevalence of mental disorders in the younger cohort while women had a higher prevalence in the older cohort Low educational attainment was associated with higher rates of diagnosis alcohol and other psychoactive substance use was higher among those with a psychiatric diagnosis Although those with a psychiatric diagnosis were less satisfied with their own health only one-fifth had seen a mental health professional in the previous year A psychiatric diagnosis increased the suicide risk by 5.6 to 9.1 times the best cutoff points were 5/6 for men and 7/8 for women The prevalence and comorbidity of mental disorders were high in both cohorts and comparable to those in larger Brazilian cities few individuals with a diagnosis had sought specialized care These data suggest that the mental health gap is still significant in Brazil the overall estimated prevalence of mental disorders was consistent across various studies conducted in large cities It remains unclear whether other factors such as different urbanization rates and socioeconomic backgrounds influence the prevalence rates in Ribeirão Preto we sought to assess the performance of a screening instrument the Self-Reporting Questionnaire (SRQ-20) within our sample We hypothesized that the prevalence of mental disorders and comorbidity rates in our sample would be high and comparable to those previously reported for other populations we anticipated that individuals with a psychiatric diagnosis would exhibit increased social vulnerability correlates and an elevated risk of suicide The first Ribeirão Preto cohort commenced in 1978/1979 and stands as the oldest Brazilian birth cohort We used data from the follow-up visits that occurred in 2016 and 2017 Ribeirão Preto is a medium-sized city, with around 700,000 inhabitants (2022) located in the state of São Paulo, 320 km from São Paulo city, the capital of São Paulo State. The economy is based on agribusiness and service provision, with a GDP per capita of R$55,484.91 (2021) and HDI = 0.800 (2010) (https://cidades.ibge.gov.br/) participants from both cohorts were invited for a new wave of assessments using their most recent addresses and phone numbers supplemented by invitations through local media advertisements and searches in electronic medical records and list of military recruits The assessment procedures were conducted at the University Hospital of Ribeirão Preto Medical School Participants from the 1978/1979 cohort were aged 37–38 years and those from the 1994 cohort were aged 22–23 years We categorized self-reported skin color as “white” or “non-white” (black We considered “married” those who cohabited with a partner and “single” the remaining individuals Educational level was stratified into three categories representing the Brazilian educational system (< 9 years: primary and lower secondary school; 9–12 years: upper secondary school; >12 years: college and above) The MINI comprises nineteen modules: eighteen provide diagnoses from the DSM-IV and one provides additional information about suicidality generalized anxiety disorder and antisocial personality disorder remained as described in the MINI The suicidality module was analyzed separately and excluded from the psychiatric diagnosis prevalence calculations Detailed information on the adapted diagnostic variables is provided in the Supplementary Table S2 we excluded individuals with psychotic disorders and those diagnosed exclusively with alcohol or substance-related problems according to the MINI from the SRQ-20 analysis Satisfaction with health as a patient-related outcome was measured by a single question (“How satisfied are you with your own health?”) graded as very dissatisfied We dichotomized the answers as “dissatisfied” (very dissatisfied All participants were questioned if they had seen a health professional in the previous 12 months and if they did they were explicitly asked if they had seen a psychologist or a psychiatrist We described the raw missing data in tables Missing data were not considered for frequency analyses or statistics The data were analyzed with IBM SPSS Statistics for Windows Pearson’s chi-square test and Fisher’s exact test were used for categorical variables Confidence intervals for prevalence rates were estimated using a bootstrapping method with one thousand replications We employed binary logistic regression to estimate the odds ratio for each sociodemographic variable Values of p < 0.05 were considered significant Receiver operating characteristics (ROC) curve was plotted to compare the SRQ-20 with the MINI (considered the “gold standard” in our analysis) We analyzed the ROC curves visually and through the provided coordinates to determine the best cutoff point for our sample considering the use of the SRQ-20 as a screening tool for common mental disorders The misclassification rates were calculated after choosing a cutoff point for our sample The sample assessed in 2016/2017 consisted of 1,769 individuals from the 1978/1979 cohort (25.9% of the baseline sample) and 1,037 from the 1994 cohort (36.4% of the baseline sample) A comparison of baseline characteristics between our sample and the individuals not assessed in 2016/2017 revealed significant differences in sex at birth and maternal education while gestational age and birth weight showed similar patterns (Supplementary Table S3) Table 1 shows that most individuals were women and self-reported skin color as white Participants from the 1978/1979 cohort were more often married and financially independent individuals from the 1994 cohort had higher education levels The older cohort sought medical consultations more frequently in the previous year than did the younger cohort The prevalence of any mental disorder was 28.6% (95% CI 26.3–30.8%; n = 506) in the 1978/1979 cohort and 31.0% (95% CI 28.0–34.2%; n = 321) in the 1994 cohort. Table 2 shows that the prevalence of each diagnosis was similar in both cohorts except for substance-related problems (twice as frequent in the 1994 cohort) and panic disorder (twice as frequent in the 1978/1979 cohort) Major depressive disorder and generalized anxiety disorder were the most frequent diagnoses in both cohorts Overall diagnoses, as described in Table 2 exceeded the total number of individuals with any mental disorder due to psychiatric comorbidity 42.7% (95% CI 38.6–47.1%) and 43.3% (95% CI 38.2–48.4%) had two or more psychiatric diagnoses in the older and younger cohorts Supplementary Table S4 provides a detailed account of the observed comorbidities Network graph of psychiatric diagnoses and comorbidities according to the MINI among individuals from two birth cohorts from Ribeirão Preto Circles size represent the prevalence of each isolated diagnosis Lines width represent comorbidity rates between pairs of diagnoses The comorbidity of other psychiatric diagnoses with alcohol and other substance use was also relevant Among those individuals with alcohol-related problems 73.7% (95% CI 63.2–84.1%) and 68.6% (95% CI 54.8–80.8%) had another psychiatric diagnosis in the older and younger cohorts These proportions were significantly different from the sole diagnosis of alcohol-related problems (p < 0.001) Among those with substance-related problems 54.4% (95% CI 42.3–66.1%) and 50.0% (95% CI 41.0–58.7%) had another psychiatric diagnosis These proportions were also significantly different from the sole diagnosis of substance-related problems (p < 0.001) Table 3 presents the rates of psychiatric diagnoses for each sociodemographic variable all variables showed significant differences between individuals with and without psychiatric disorders in the univariable analysis We observed higher rates of diagnosis among women (OR = 1.83 and those who were financially dependent (OR = 1.89 all variables remained significantly associated with the occurrence of a mental disorder except self-reported skin color (aOR = 1.14 and intermediate level of education attainment (aOR = 1.26 and financial dependence status were not significantly associated with the risk of psychiatric diagnosis Although lower education attainment was linked to a higher risk of mental disorders in the univariable analysis (< 9 years: OR = 1.85 this association did not persist in the multivariable analysis single individuals in the younger cohort had a lower risk of psychiatric diagnosis (aOR = 0.68 Table 4 details the satisfaction with health and health service use characteristics of the sample Individuals with mental disorders were more prone to report low satisfaction with health than individuals without mental disorders (1978/1979: OR = 2.14 They were also more likely to have sought consultation with a mental health professional in the previous year (1978/1979: OR = 2.64 although only approximately one-fifth consulted a mental health practitioner Consultation with any health professional was similar in both groups Individuals with any psychiatric diagnosis carried a 5 to 9-fold increased likelihood of having suicide risk as assessed by the MINI (cohort 1978/1979: OR = 9.19 they were 5 to 7 times more likely to report a previous suicide attempt (cohort 1978/1979: OR = 7.80 The best cutoff points for our sample were 5/6 for men and 7/8 for women the 5/6 cutoff provided a sensitivity ranging from 0.758 to 0.772 and a specificity ranging from 0.658 to 0.688 the 7/8 cutoff yielded a sensitivity ranging from 0.782 to 0.814 and a specificity ranging from 0.621 to 0.635 The misclassification rates varied from 0.30 to 0.33 Supplementary Table S5 presents detailed SRQ-20 performance data We aimed to estimate the prevalence of mental disorders using the structured interview MINI in adults (37–38 years old) and young adults (22–23 years old) from two Brazilian birth cohorts We observed a high prevalence of mental disorders in both samples (28.6% and 31% respectively) with substantial psychiatric comorbidity Since we overlooked the diagnosis of borderline personality disorder in our study some of these individuals may have been misclassified as having bipolar disorder thereby overestimating the prevalence rate Our cross-sectional design prevents us from concluding whether the observed sex at birth disparities between the two cohorts are due to age-specific or cohort-specific features we propose some hypotheses for this phenomenon we showed high comorbidity rates between substance-related problems and other mental disorders in the younger cohort we believe the prevalence of mental disorders in men from the younger cohort was inflated by the diagnosis of substance-related problems and its possible comorbidities These data suggest that the mental health gap remains significant in Brazil Our results suggest that satisfaction with health is responsive to the presence of a mental disorder; therefore it is a potential outcome to estimate the influence of psychopathology on the patient this is the first time that the SRQ-20 was tested with the MINI as the gold standard which naturally impairs comparisons with previous studies our sample comprised young adults from two birth cohorts instead of primary care patients the instrument’s original target population our cross-sectional design prevents analysis of causality and the complexity of mental disorders across the lifespan Future studies should consider longitudinal approaches Our study highlights the significant and concerning prevalence of psychiatric disorders among young adults and adults from two birth cohorts in Ribeirão Preto with similar rates when compared to larger metropolitan areas We observed noteworthy rates of comorbid psychiatric disorders especially alcohol and substance-related disorders The psychiatric diagnoses were associated with social vulnerabilities such as lower educational attainment and financial dependence which reflect the socioeconomic challenges faced by low- and middle-income countries Despite the negative impacts of mental disorders including worse self-rated health satisfaction only a minority of individuals with a psychiatric diagnosis had sought evaluation from a mental health professional even when examining one of the wealthiest regions in the country a substantial mental health gap persists in Brazil our data can contribute to the limited scientific literature on psychiatric epidemiology in low- and middle-income countries potentially informing regional mental health policies The data that support the findings of this study are available from NESCA (Núcleo de Estudos da Saúde da Criança e do Adolescente) but restrictions apply to the availability of these data which were used under license for the current study Data are however available from the authors upon reasonable request and with permission of NESCA Diagnostic and Statistical Manual of Mental Disorders Mini International Neuropsychiatric Interview Strengthening the Reporting of Observational Studies in Epidemiology Global burden of Disease and the impact of Mental and Addictive disorders A narrative historical review of psychiatric epidemiology in Brazil: Focus on social and cultural determinants of mental health Brazilian multicentric study of psychiatric morbidity Mental disorders in megacities: findings from the São Paulo megacity mental health survey Common mental disorders and sociodemographic characteristics: baseline findings of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) Associations between primary health care strategies and outcomes of mental disorders and adults in the RPS Birth Cohort Consortium (Ribeirão Preto RPS Brazilian birth Cohort Consortium (Ribeirão Preto Cohort Profile: the 1978-79 Ribeirao Preto (Brazil) birth cohort study Maternal smoking during pregnancy and primary headache in school-aged children: a cohort study Profile of three Brazilian birth cohort studies in Ribeirão Preto Prevalence and correlates of major depressive disorder: a systematic review Poverty and common mental disorders in low and middle income countries: a systematic review The Mini-International Neuropsychiatric Interview (M.I.N.I.): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10 Mini International Neuropsychiatric interview (MINI): validação de entrevista breve para diagnóstico de transtornos mentais Validity and applicability of the Mini International Neuropsychiatric interview administered by family medicine residents in primary health care in Brazil Mental disorders in primary health care: a study of their frequency and diagnosis in four developing countries A validity study of a psychiatric screening questionnaire (SRQ-20) in primary care in the city of Sao Paulo Avaliação De Desempenho do self-reporting questionnaire como instrumento de rastreamento psiquiátrico: um estudo comparativo com o structured clinical interview for DSM-IV-TR A User’s guide to the self reporting questionnaire (SRQ / compiled by M Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization’s World Mental Health Survey Initiative Bipolar disorder prevalence: a systematic review and meta-analysis of the literature Diagnosis of bipolar and major depressive disorders: the appropriateness of MINI compared to the clinical interview in a sample of patients with mood disorders in tertiary mental health care Borderline personality disorder and the misdiagnosis of bipolar disorder and Sociodemographic correlates of Psychiatric diagnoses reported in the all of Us Research Program The epidemiology of alcohol use disorders cross-nationally: findings from the World Mental Health surveys Cross-national patterns of substance use disorder treatment and associations with mental disorder comorbidity in the WHO World Mental Health Surveys Prevalence of depressive disorder in the adult population of Latin America: a systematic review and meta-analysis Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries One-month prevalence of mental disorders in the United States and sociodemographic characteristics: the Epidemiologic Catchment Area study and substance use disorders in China and India: a review Evolução Da Escolaridade Esperada no Brasil Ao Longo do século XX The downward spiral of mental disorders and educational attainment: a systematic review on early school leaving Patterns and predictors of health service use among people with mental disorders in São Paulo metropolitan area Socio-economic variations in the mental health treatment gap for people with anxiety and substance use disorders: results from the WHO World Mental Health (WMH) surveys Treatment gap for anxiety disorders is global: results of the World Mental Health Surveys in 21 countries Estimating treatment coverage for people with substance use disorders: an analysis of data from the World Mental Health surveys Community-based mental health services in Brazil Mental Health Gap Action Programme (mhGAP) guideline for mental A history of health-related quality of life outcomes in psychiatry The association between mental disorders and suicide: a systematic review and meta-analysis of record linkage studies Download references and CMD-B receive fellowship from the National Council for Scientific and Technological Development (CNPq) The research Project was financed by CNPq (grant number: 400943/2013-1) and PROEP-LABS/ILMD/FIOCRUZ AMAZÔNIA (2023–2025) Luis Felipe Scarabelot & Cristina Marta Del-Ben Marco Antonio Barbieri & Heloisa Bettiol All authors read and approved the final manuscript The Ethics Committee of the Ribeirão Preto Medical School granted approval for this study (process number: 49992521.3.0000.5440) Written informed consent was obtained from all participants in this study The authors declare no competing interests Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Below is the link to the electronic supplementary material Download citation DOI: https://doi.org/10.1186/s12889-024-19957-x Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Two temples to be built in South America by The Church of Jesus Christ of Latter-day Saints have marked groundbreaking milestones Groundbreaking services were held for the Ribeirão Preto Brazil Temple on Saturday A groundbreaking date was announced today for the Santiago West Chile Temple as well as the site location for the Springfield Missouri Temple Ground has been broken for the Ribeirão Preto Brazil Temple. Elder Joni L. Koch presided and offered the dedicatory prayer With a beautiful clear-blue skyline and newly graded dirt at the temple site as the setting the ceremony took place with several hundred attendees Local adult and youth Church members spoke “Our hearts are intertwined in love and harmony for this inspiring and significant ceremony,” said Elder Koch as he began the dedicatory prayer He offered words in reverence and expressed gratitude for Jesus Christ “We give thanks for You having sent Your Son Jesus Christ to earth restored Church and covenants enable us to return to Your presence,” Elder Koch said Elder Koch also paid a heartfelt tribute to early Latter-day Saints in the area “The example of these pioneers has been a moral and spiritual support for your kingdom to flourish from these few who stood firm so that thousands of Latter-day Saints could on this day — here in this part of the earth — enjoy this sublime moment.” He later served a full-time mission in the Brazil São Paulo North Mission He was sustained as a General Authority Seventy in April 2017 the country is home to nearly 1.5 million Latter-day Saints in more than 2,170 congregations The First Presidency of The Church of Jesus Christ of Latter-day Saints has released the date of the groundbreaking ceremony for the Santiago West Chile Temple; it will take place on August 17, 2024. Elder Alan R. Walker second counselor in the South America South Area Presidency Attendance at the site will be by invitation only Additional details will be released as the date of the groundbreaking approaches An exterior artistic rendering has also been released Church President Russell M. Nelson announced this house of the Lord in October 2021 “I plead with you today to counter the lure of the world by making time for the Lord in your life — each and every day,” he said before announcing 13 new temples The site location was published in December 2022 The temple will be built at Primo de Rivera 1551 Plans call for a single-story temple of approximately 12,500 square feet One of the Church’s earliest leaders served a mission in Chile in 1851 the country has become home to more than 600,000 Latter-day Saints in 571 congregations The First Presidency of The Church of Jesus Christ of Latter-day Saints has released the site location for the Springfield Missouri Temple The Springfield Missouri Temple will be built on a portion of a 38-acre site located at 2720 East Farm Road #188 Plans call for a single-story temple of approximately 29,000 square feet This new house of the Lord was announced in April 2023 by President Russel M “Jesus Christ is the reason we build temples,” President Nelson said Making covenants and receiving essential ordinances in the temple as well as seeking to draw closer to Him there will bless your life in ways no other kind of worship can we are doing all within our power to make the blessings of the temple more accessible to our members around the world.” In addition to the Springfield Missouri Temple, the “Show-Me” state has two other houses of the Lord in operation. These are the St. Louis and Kansas City Missouri temples Missouri is home to more than 80,000 Latter-day Saints in nearly 165 congregations and its surrounding counties were important gathering places for Latter-day Saints Temples differ from the Church’s meetinghouses (chapels) All are welcome to attend Sunday worship services and other weekday activities at local meetinghouses The primary purpose of temples is for faithful members of The Church of Jesus Christ of Latter-day Saints to participate in sacred ceremonies that unite families forever You are about to access Constant Contacts (http://visitor.constantcontact.com) You are now leaving a website maintained by The Church of Jesus Christ of Latter-day Saints We provide the link to this third party's website solely as a convenience to you and security practices that differ from those on our website By referring or linking you to this website we do not endorse or guarantee this content If you would like to stay on the page you are viewing please click Cancel To download media files, please first review and agree to the Terms of Use Download a photo or video by clicking or tapping on it To download all photos or videos related to this article select the links at the bottom of each section Two factory workers died in the Urupes municipality while fighting flames as soaring temperatures and low humidity are stoking dangerous fire conditions in the state Brazil has meanwhile deployed military aircraft to combat raging wildfires in the densely populated state of Sao Paulo where authorities suspect arsonists are responsible for the blazes President Lula da Silva and the Environment  Minister on Sunday announced a "war against the fire" as emergency measures were put in place and federal police began investigations into what they described as an "atypical situation that has caused extensive damage 3,000 firefighters have been deployed nationwide and the government has promised federal assistance to the states most affected the country's most populous state with some 44 million residents decreed a state of emergency in 45 municipalities and said two people suspected of starting fires had been arrested With dense smoke drifting across a wide swath of Brazil - even reaching the capital city Brasilia 720 kilometres to the north -  flights have been cancelled and travel on some roads has been halted The situation was also critical in São Jose do Rio Preto where more than 335 fires have been registered recently Brazil has been hit by a series of extreme weather events most recently a massive wildfire in the Pantanal wetlands in June Brazil also experienced once-in-a-century flooding in the State of Rio Grande do Sul which left more than 170 people dead and displaced more than half a million people from their homes Thank you for reading our article. You can keep up-to-date by subscribing to our daily newsletter. Just click here Brazil was deploying military aircraft as part of a “war” against wildfires ravaging the southeastern state of Sao Paulo with authorities on Sunday warning that arsonists were setting blazes Following a crisis meeting of Brazilian President Luiz Inacio Lula da Silva’s Cabinet Brazilian Minister of the Environment and Climate Change Marina Silva announced a “war against the fire” and said federal police were investigating the “atypical situation” that has caused extensive damage “So far we have not detected any fire caused by lightning which means there are people starting fires,” Lula said in a video that he posted on social media after meeting with Silva Sao Paulo Governor Tarcisio de Freitas decreed a state of emergency in 45 municipalities and said two people suspected of starting fires had been arrested Lula promised federal assistance to the states in fighting the blazes saying there were already 3,000 firefighters working nationwide With dense smoke drifting across a wide swath of Brazil — even reaching the capital 720km to the north — several flights were canceled and travel on some roads was halted “I stuck my nose out last night at about 7pm and I had a lot of trouble breathing,” 66-year-old retiree Carlos Rodrigues said “I’ve lived here 32 years and I’ve never seen anything like it.” Two factory workers died on Friday in Urupes The military aircraft being deployed include a KC-390 Embraer a converted troop transport craft that can drop up to 12,000 liters of water on fire zones The Embraer was sent to one of the communities most threatened a city of 700,000 inhabitants about 300km from Sao Paulo but Silva said that the plane “was unable to operate because of the amount of smoke.” “That gives you an idea of the problem,” she said Videos posted on social media showed the city plunged into near-darkness by a dense layer of smoke “It’s apocalyptic,” a person is heard saying in one video Authorities were hoping rains that fell on Sunday would help alleviate the crisis farm fields have burned and scores of cattle have died De Freitas said that 10 million reals (US$1.8 million) were being allocated to help farmers who lose crops or livestock Sao Paulo is experiencing its worst month for fires in decades the Brazilian National Institute for Space Research said The Brazilian government directly linked the situation to climate change “Even the deniers can no longer deny the climate crisis,” Lula wrote on social media “We have to fight climate change with a lot of intelligence and with financing from the richest countries that have already destroyed their forests.” The First Presidency of The Church of Jesus Christ of Latter-day Saints has set a June 22 groundbreaking date for the Ribeirão Preto Brazil Temple one of 23 total temples in South America’s largest country Elder Joni L. Koch will preside and offer a prayer on the site and the construction process Of the Church’s 350 temples total worldwide that are dedicated under construction or in planning and design nine have concluded or are concluding construction and have been announced for dedication The Ribeirão Preto groundbreaking date was first published Monday, May 13, on ChurchofJesusChrist.org Attendance at the groundbreaking will be by invitation only with additional details on the event to be released as the date draws closer Zanin explained his research in a video posted by the Ribeirão Preto Blood Center (image: screenshot) a PhD candidate at the University of São Paulo supported by FAPESP won an award at an international rheumatology conference “My project is a laboratory 3D skin model that uses several cellular components including fibroblasts, which are cells present in human skin, and also immune system cells called monocytes. This skin is able to harden and thicken, mimicking what happens to the patient,” Zanin says in a video posted on the Ribeirão Preto Blood Center’s YouTube channel is a rare chronic auto-immune disease of unknown cause A buildup of collagen and other proteins in various tissues results in degenerative alterations and scarring in the skin the accumulation of collagen and other extracellular matrix molecules thickens and stiffens the skin “The quality of life is significantly impaired The patient has difficulty moving about and performing basic activities such as teeth cleaning,” he said The 3D skin model can also help develop treatments by offering an effective alternative to animal testing “It can help us understand how the disease progresses and combat it with novel medications and therapeutic targets,” he said his project received a grant from the European Alliance of Associations for Rheumatology (EULAR) enabling him to attend the workshop in Italy SAO PAULO (AP) — Wildfires in Brazil's southern Sao Paulo state have killed at least two people At least 36 cities have been put on high alert Local and federal authorities were stepping up efforts to control the flames The fires have raged in the region outside the city of Sao Paulo one of Latin America's most populous cities with more than 11 million residents At least 7,300 government workers and volunteers had been deployed across the state to “contain the advance and put out these fires,” de Freitas told journalists While the city largely hasn't been affected by the fires videos on social media show the skies of rural areas filled with smoke and burning trees along the highway The government said that in the city of Urupes two employees working at an industrial plant died on Friday while trying to fight back a fire The region has been plagued with the worst wildfires in decades according to local news organization Folha de S.Paulo which counted 4,973 fires in the region just this year Leite Lopes State Airport in Ribeirao Preto Smoke from wildfires fills the air above the Candido Portinari highway in Ribeirao Preto Smoke stemming from nearby wildfires and dry weather covers the Guara neighborhood of Brasilia Smoke stemming from nearby wildfires and dry weather covers Park Way in Brasilia Smoke stemming from nearby wildfires and dry weather covers the Aguas Claras neighborhood of Brasilia Smoke from wildfires fills the air above the Anhanguera Highway in Ribeirao Preto A bird stands on burnt reeds during nearby wildfires in Ribeirao Preto Smoke from wildfires fills the air near above the Mario Donega highway in Ribeirao Preto Burnt trees lie next to condominiums as wildfires rage in Sao Paulo state in Ribeirao Preto Smoke from wildfires fills the air in Ribeirao Preto Iowa (AP) — The president of the nation’s largest union for federal workers said Monday the organization’s ongoing staff downsizing will devastate the services it provides members and threatens the group’s survival national president of the American Federation of Government Employees said an executive order signed by President Donald Trump in March removed over 200,000 of its dues-paying members The order stripped union rights from employees in several executive branch agencies including the Department of Defense and the Department of Veterans Affairs AFGE and other unions are fighting the order in court as illegal and retaliatory But Kelley said the order has already taken a “very direct hit” on the group’s finances because agencies stopped collecting union dues from paychecks Saying it had lost over half of its dues revenue and faced a major budget shortfall AFGE’s National Executive Council last month approved a plan to slash its staffing levels from 355 to 151 The union has offered early retirements and buyouts to some staff and employees are anticipating layoffs in the coming days “It’s going to be devastating,” Kelley told reporters on a Zoom conference celebrating Public Service Recognition Week because members have joined this union because they expect us to provide a certain amount of services.” Local unions have already been warned that they will face longer response times from national staff members and less legal help on non-essential matters Kelley said AFGE is pushing its remaining members to sign up to have their dues withdrawn automatically from their bank accounts The union said Monday that about 120,000 of its members have signed up the union represents about 820,000 federal workers Kelley said the group had been successful in pushing back against Trump's dramatic downsizing and reshaping of the federal government filing nine lawsuits and rallying the public to its cause “We've been beating him in the court of law and also in the court of public opinion,” he said White House spokesperson Anna Kelly said Trump issued the order to cancel collective bargaining agreements that he believed risked national security interests “He will always prioritize public safety for the American people,” she said deliver the invocation at the Democratic National Convention The Church of Jesus Christ of Latter-day Saints has announced the groundbreaking date for the Ribeirão Prêto Brazil Temple The artist renderings for the Maceió Brazil Temple and the Huehuetenango Guatemala Temple have also been released Groundbreaking services for the Ribeirão Prêto Brazil Temple will be held on June 22 will preside and offer a dedicatory prayer Nelson announced this house of the Lord in October 2022 “May you focus on the temple in ways you never have before I bless you to grow closer to God and Jesus Christ every day,” he said before announcing 18 new temples Plans call for a single-story temple of approximately 32,000 square feet An artist’s rendering of the Maceió Brazil Temple has been released. President Russell M. Nelson announced the temple in April 2022. The site location was released in March 2023 An artist’s rendering of the Huehuetenango Guatemala Temple has been released. President Nelson announced the temple in October 2022. The site location was released in March 2023 To read more about each of these new temples, visit Church Newsroom ► You may also like: Which Latter-day Saint temples are under construction around the world? Groundbreaking services for the Ribeirão Prêto Brazil Temple will be held on June 22, 2024. Elder Joni L. Koch Church President Russell M. Nelson announced this house of the Lord in October 2022. “May you focus on the temple in ways you never have before. I bless you to grow closer to God and Jesus Christ every day,” he said before announcing 18 new temples Brazil has 23 temples in use, announced or under construction. The Ribeirão Preto Brazil Temple will be one of three temples in the construction phase of development. The Belo Horizonte Brazil Temple and the Salvador Brazil Temple (dedication date October 20 Today, there are nearly 1.5 million Latter-day Saints in Brazil (more than any other country aside from the United States and Mexico) in approximately 2,175 congregations Missionaries of The Church of Jesus Christ of Latter-day Saints began preaching in southern Brazil in 1928 The Portuguese translation of the Book of Mormon was published in 1940 igniting a new era of growth in the country An artist’s rendering of the Maceió Brazil Temple has been released. President Russell M. Nelson announced the temple in April 2022. The site location was released in March 2023 An artist’s rendering of the Huehuetenango Guatemala Temple has been released. President Nelson announced the temple in October 2022. The site location was released in March 2023 Latter-day Saints worship in temples for several reasons: to make sacred promises with God to learn more about God’s plan for His children and the central role of Jesus Christ in that plan Ground was broken for the Ribeirão Preto Brazil Temple on June 22, 2024, with Elder Joni L. Koch — General Authority Seventy and president of the Brazil Area — presiding He spoke of serving as a full-time missionary in Ribeirão Preto 44 years earlier and being welcomed by many local Latter-day Saints He also paid tribute to the early and longtime Saints in the Ribeirão Preto area in the southeast region of Brazil In his dedicatory prayer of the site “We remember with appreciation those who were the first members of the Church in this region The example of these pioneers has been a moral and spiritual support for Thy kingdom to flourish from these few who stood firm so that thousands of Latter-day Saints could on this day — here in this part of the earth — enjoy this sublime moment.” According to site plans released by the Church on Nov the Ribeirão Preto Brazil Temple will be a single-story building of approximately 32,000 square feet The edifice will be built at Avenida Antonio Marcal and Rua Jose Brandani Architectural renderings of the house of the Lord released by the Church on Jan show an off-white exterior surrounded by vertical frosted windows A five-level tower topped by a pyramidal dome with a needle pointing to the sky stands above the center of the building grass fields and flower gardens adorn the grounds Avenida Antônio Marçal The First Presidency of The Church of Jesus Christ of Latter-day Saints has released the artistic renderings for three houses of the Lord: two in Brazil and one in California An artist’s rendering of the Londrina Brazil Temple has been released President Russell M. Nelson announced the Londrina Brazil Temple in October 2022. The site location for this temple was published in November 2022 An artist’s rendering of another temple in Brazil has been released President Russell M. Nelson announced the Ribeirão Prêto Brazil Temple in October 2022. The site location was released in November 2022 Today, there are nearly 1.5 million Latter-day Saints in Brazil in more than 2,175 congregations “Brazil is part of the heart of the Church.” California is home to nearly 730,000 Latter-day Saints in more than 1,130 congregations The primary purpose of temples is for faithful members of the Church of Jesus Christ to participate in sacred ceremonies that unite families forever The First Presidency has announced the site locations for six temples of The Church of Jesus Christ of Latter-day Saints — four in South America The six temples with newly announced site locations and general size dimensions are: The locations were first published Monday, Nov. 28, on ChurchofJesusChrist.org Detailed design plans are still being developed for each temple with additional information — such as exterior renderings and groundbreakings — to be made public later The Londrina Brazil Temple is projected as a single-story temple of approximately 32,000 square feet and will be built at Avenida Harry Prochet Nearly 1.5 million Latter-day Saints reside in Brazil Missionary work began in South America’s largest nation in 1928 the Ribeirão Preto Brazil Temple will be built at Avenida Antonio Marcal and Rua Jose Brandani in Ribeirão Preto The Santos Brazil Temple — projected as a two-story temple of approximately 23,000 square feet — will be built at Avenida Doutor Waldemar Leão The temple will be the first in Santos and the third in the greater São Paulo metropolitan area With plans calling for a single-story building of approximately 29,000 square feet the Santa Cruz Bolivia Temple will be built at Avenida Quinto Anilla y Santa Rosa (Av Bolivia has two other temples — the Cochabamba Bolivia Temple, dedicated in April 2000, and the La Paz Bolivia Temple Over 217,000 members of the Church in more than 270 congregations live in the South American country A 1.26-acre site near Dachang Road and Dehua Street in the Niaosong District of Kaohsiung City 10,900-square-foot Kaohsiung Taiwan Temple will be built Taiwan is home to more than 62,000 Latter-day Saints in nearly 100 congregations, with missionaries first having arrived in Taiwan in 1956. The Taipei Taiwan Temple was dedicated in November 1984 Planned as a two-story temple of approximately 14,900 square feet the Wellington New Zealand Temple will sit on a 3.35-acre site located near Okowai Road and Whitford Brown Avenue in Aotea An ancillary building with arrival facilities and patron housing is also planned for the site Over 108,000 Church members in more than 210 congregations reside in the South Pacific island nation with the first Latter-day Saint baptized in New Zealand in 1854 The First Presidency of The Church of Jesus Christ of Latter-day Saints has released the exterior renderings of three announced temples still in planning and design stages — the Bakersfield California Londrina Brazil and Ribeirão Preto Brazil temples All three have had their site locations officially released previously. The renderings were first published Monday, Jan. 8, on ChurchofJesusChrist.org Groundbreaking dates for the three temples have not been scheduled and will be announced later Projected to be a single-story building of approximately 30,000 square feet the temple is planned for a 13.07-acre site at the northwest corner of the intersection of Stockdale Highway and Jewetta Avenue in Bakersfield The site will also feature a distribution center and new meetinghouse California is home to nearly 730,000 Latter-day Saints in more than 1,130 congregations and a total of 12 temples that are dedicated President Nelson announced new temples for Londrina and Ribeirão Preto in Brazil, which were two of the 18 new temple locations identified on Oct at the conclusion of the October 2022 general conference In addition to both temples being announced on the same day, both also had their respective site locations released on the same day the month after being announced The shared publications of the renderings makes it three times together for the two Brazilian temples The Londrina and Ribeirão Preto temples are among the 22 total houses of the Lord in Brazil — dedicated and operating under construction or announced and in planning Our Standards: The Thomson Reuters Trust Principles., opens new tab Covers agricultural commodities and biofuels, including production, trade and transportation, based in New York. Former Brazil correspondent and climate/environment reporter. Brazilian, holds a Bachelor of Journalism degree and has done post-graduate studies in Environmental Reporting from Germany's InWent Institute and Foreign Policy and International Political Economy from Harvard University. Avid soccer and tennis player. , opens new tab Browse an unrivalled portfolio of real-time and historical market data and insights from worldwide sources and experts. , opens new tabScreen for heightened risk individual and entities globally to help uncover hidden risks in business relationships and human networks. © 2025 Reuters. All rights reserved Rains on the coast of São Paulo isolated the Ribeirão Silveira Indigenous Land telegram Join our Telegram channel! telegram but there were no reports of dead or wounded the TI Ribeirão Silveira has five villages and covers the municipalities of São Sebastião Guarani Mbya and Ñandeva peoples live.  “It was the first time I had seen such a large amount of rain A piece of the slope fell and a giant boulder came rolling down It's a good thing there was a tree on the path that held it because everything was lost," chief Adolfo Timotio from the Guarani Rio Silveira Indigenous Village the indigenous community is now safe and no one remains stranded The National Foundation for Indigenous Peoples (Funai) is on site to assist the community collaborating with food distribution and dialogue with authorities The Articulation of the Indigenous Peoples of the Southeast Region (ArpinSudeste) together with the Articulation of the Indigenous Peoples of Brazil (Apib) launched an alert for the situation of all indigenous people living on the north coast of São Paulo.  The Municipality of Bertioga directed an emergency care trailer and a family health unit to the neighborhood of Boraceia to temporarily replace the indigenous health post maintained by the municipal administration of São Sebastião which mainly hit the municipality of São Sebastião between Serra do Mar and the Rio-Santos highway pushed into these regions by real estate speculation and rising prices The disaster alerts us to the severity of climate change and its consequences on the lives of marginalized and vulnerable populations This social phenomenon has a name: it is environmental racism More than a month after the declaration of a health emergency in the Yanomami Indigenous Land (RR), the crisis is far from over. In the early hours of Wednesday (22), the federal base of IBAMA located in the village of Palimiú suffered attacks from miners The site has the function of barring the entry of clandestine vessels in the territory and completed only two weeks of operation Armed miners broke through the blockade set up on the Uraricoera River and fired at federal agents who boarded one of the vessels The criminals went down the river in seven “voadeiras” The shipment was identified by drones operated by Ibama inspectors In the midst of the wave of violence practiced by miners, Indigenous people call for protection from retaliation – The beginning of the process of de-intrusion in the Yanomami TI increases the fear of other peoples that the problem will get worse According to a survey by indigenous groups at least 18 leaders of the Munduruku ethnic group are threatened with death near the upper course of the Tapajós River coordinator of the Munduruku Wakoborûn Women's Association who had to leave her home under pressure from criminals An official from the Special Indigenous Sanitary District (DSEI) from Vale do Javari and an assistant were tied up and robbed by invaders close to the headquarters of the municipality of Atalaia do Norte (AM) two engines and more than 3 liters of fuel The municipality is home to most of the Vale do Javari reserve the second largest indigenous territory in the country marked by conflicts such as drug trafficking and illegal fishing It was in this region where Bruno Pereira and Dom Phillips were murdered A delegation from the federal government landed in the region to discuss security in the area Um new project aims to guarantee access to quality water in the Yanomami Indigenous Land to reduce the incidence of acute diarrhea and infant mortality from causes related to dehydration and malnutrition.  from the Sergio Arouca National School of Public Health (Ensp/Fiocruz) the team will examine samples of the quality of water for human consumption and sediments in the villages of Maturacá and Ariabu in São Gabriel da Waterfall (AM).   aims to develop socio-technical adaptations (social technologies) that guarantee access to water in adequate quantity and quality for the selected communities in the Yanomami Indigenous Land.  The researcher also intends to develop a talking map with potential contamination risk factors and available water supply points in the village The team will assess the management of rivers The most relevant news for you to form your opinion on the socio-environmental agenda LAST ISSUE Introduction: Arterial hypertension is a global health problem and one of the main risk factors for cardiovascular diseases (CVD), and therefore for morbidity and mortality among adult men and women. Factors related to obstetric history, family history, sociodemographic characteristics, and lifestyle habits are known determinants of arterial hypertension. Conclusion: We conclude that ethnicity, self-reported hypertension, and gestational hypertension are associated with arterial hypertension measured by ABPM. Volume 13 - 2022 | https://doi.org/10.3389/fphar.2022.992595 Introduction: Arterial hypertension is a global health problem and one of the main risk factors for cardiovascular diseases (CVD) and therefore for morbidity and mortality among adult men and women and lifestyle habits are known determinants of arterial hypertension Methods: Case-control study of women belonging to the 1978/79 birth cohort conducted in the city of Ribeirão Preto/SP and biometric and biophysical markers associated with blood pressure measured by 24-h ambulatory blood pressure monitoring (ABPM) were assessed in women aged 38–39 years We want to study which variables of the previous sentence are related to the presence of hypertension measured by ABPM Results: Data from 281 women were analyzed and gestational hypertension reported by the women were significantly associated with the presence of hypertension measured by ABPM anthropometric measurements or serum levels of cardiovascular markers were not associated with the presence of hypertension measured by ABPM and gestational hypertension are associated with arterial hypertension measured by ABPM Studies of blood pressure measurements are uncommon in the Brazilian population and most existing ones are restricted to certain locations and using different information, a fact impairing comparison of the data (Jardim et al., 2020). In addition, different diagnostic criteria exist for estimating the population prevalence of arterial hypertension, such as cut-off point and the use or not of associated medications (Zhou et al., 2021) Our hypothesis was that with the technique measured by ambulatory blood pressure monitoring the study would be able to identify hypertension in the woman’s gestational phase in self-reported hypertension and other variables in women aged close to 40 years The inclusion criteria were female participants not pregnant at the time of the interview and who accepted the measurement by ABPM And the exclusion criterion was male and women who refused to be measured by ABPM The evaluation of anthropometric measurements was made through measurements of weight Pulse wave velocity (PWV) analysis is a simple and reliable diagnostic method for the assessment of arterial stiffness (47) The computerized system Sphygmocor® Software Version 9.0 The measurement of PWV was performed with the participant in the supine position after a 5-min rest and an acclimatized room (22–24°C) An inelastic measuring tape graduated in centimeters was used to measure the distances between the carotid wrist and the sternal notch and between the sternum notch and the femoral wrist External transducers were placed directly on the skin in the right carotid artery and the right femoral artery Capture the recording of pulse waves for a minimum time interval of 10 s The PWV measurement is automatically calculated by the ratio of the carotid-femoral distance and the time interval between the two pulses The participants had blood collection performed at the Gynecology Laboratory of the Hospital das Clínicas of the Faculty of Medicine of the University of São Paulo in the city of Ribeirão Preto Blood collection was not performed on an empty stomach 20 ml of whole blood was collected and stored in conical plastic tubes (BD-Becton Dickinson The women did not use any medication that could alter the results of laboratory tests Blood samples were processed within a maximum of 2 h after collection The serum was stored at −80°C for measurement of all serum variables at the same time and glucose were quantified in an automated biochemistry analyzer (Weiner The glomerular filtration rate was estimated from creatinine and cystatin C using the CKD-EPI 2009 equation (15) Glycated hemoglobin (HbA1c) was determined by HPLC (Bio-Rad D-10 The questionnaire asked about demographic variables such as skin color and educational level (Years of schooling) and for each demographic variable mentioned above the patient was asked about the presence of comorbidities the patient was asked if she was aware of the presence of the following comorbidities: high blood glucose/diabetes and the presence of hypertension measured by the ABPM was evaluated we obtained two groups about to with concerning these variables of the presence of comorbidities the hypertensive related to these comorbidities and the normotensive related to these comorbidities the women were asked about the following paternal and maternal comorbidities: knowledge of the father’s disease hypercholesterolemia reported by the father cardiovascular disease described by the father hypercholesterolemia reported by the mother cardiovascular disease reported by the mother And for each variable of paternal or maternal comorbidity evaluated the presence or absence of hypertension Another evaluation performed was the presence of hypertension measured by MAPA in pregnant women with the following questions for women if they were aware of the following comorbidities during pregnancy: self-reported preeclampsia and gestational hypertension The installation of the device (A&D Company Limited Japan) was offered to all women on the day of the interview but the decision to use the device was voluntary Continuous and semi-continuous variables were compared using a Gauss curve Data were found to be nonparametric by the Kolmogorov-Smirnov and Shapiro-Wilk tests and were therefore reported as median and percentiles (25–75) The geometric mean was used when the sample showed a high frequency of modal values (>20%) Two independent groups were compared by the Mann-Whitney test with Bonferroni correction Categorical data were expressed as absolute (n) and relative (%) frequency The contingency matrices were analyzed by Pearson’s chi-squared test and complex matrices with p ≤ 0.05 Of the 929 patients of the cohort, only 281 underwent ABPM. Twenty-four-hour SBP and DBP were recorded, as well as sleeping and awake SBP and DBP, and are expressed as median and percentiles (Table 1) The median SBP was 113 mmHg and the median DBP was 72 mmHg Blood pressures differed between the sleep and wake periods with a median SBP and DBP of 117 and 76 mmHg during the wake period while SBP was 106 mmHg and DBP was 65 mmHg during the sleep period Description of ABPM results (n = 281) Figure 1 shows the demographic variable of the e. A significant difference (p = 0.001) was only observed for ethnicity, with a higher prevalence of hypertensive women among white patients. In Table 2 there was no difference in marital status if the women were married or lived with a partner concluding that marital status does not influence the presence or absence of hypertension measured by ABPM Receiving social benefit or educational level also did not affect the presence or absence of hypertension measured by ABPM Evaluation of the presence of hypertension (ABPM) according to demographic variables There was also no difference in the presence of other self-reported comorbidities such as thrombosis or chronic kidney disease between hypertensive and normotensive women Evaluation of the presence of hypertension (ABPM) according to the patient’s self-reported comorbidities ABPM Hypertension between self reported hypertension and obese women As can be seen in Table 4 there was no difference between patients with hypertension and without hypertension measured by ABPM when asked about the presence of paternal comorbidities The women were asked whether they had knowledge of the father’s disease whether their father had high blood glucose or diabetes and whether they had knowledge of hypercholesterolemia or CVD reported by the father The women undergoing ABPM were also asked about other paternal comorbidities such as hypertension and no association of the presence of hypertension with these variables was found Evaluation of the presence of hypertension (ABPM) according to paternal comorbidities Table 5 shows the analysis of the presence of maternal comorbidities reported by the participants according to the presence of hypertension measured by ABPM Knowledge of maternal diseases such as high blood glucose stroke or kidney disease did not differ between hypertensive and non-hypertensive women Evaluation of the presence of hypertension (ABPM) according to maternal comorbidities When we evaluated the presence of hypertensive disorders of pregnancy, we found a significant difference in patients classified as hypertensive by ABPM when asked about gestational hypertension (p < 0.0001) and we found no presence of hypertension measured by ABPM when the patient was asked about having preeclampsia (Figure 3) ABPM Hypertension between gestational hypertension and self reported hypertension there was no difference in pulse wave velocity between hypertensive and non-hypertensive women Evaluation of the presence of hypertension (ABPM) according to anthropometric measurements Evaluation of the presence of hypertension (ABPM) according to serum levels of cardiovascular disease markers The main findings of the present study were: that white women had hypertension detected by the ABPM; women who reported that they were aware of being hypertensive in the interview when they were measured by the ABPM had their hypertension demonstrated by blood pressure data; gestational hypertension measured by the ABPM presented hypertensive Two approaches were used in this study to assess the presence of arterial hypertension: one was through a questionnaire the women answered if they knew if they were hypertensive and answered positively and the other was through quantitative measures such as measured by ABPM confirming hypertension Hypertension was reported during the interview by 19.1% of the women and the prevalence of hypertensive among women measure by ABPM was 4.98% In addition 4.95% of the participants reported preeclampsia during a pregnancy In our study, we demonstrated a statistically significant difference in white skin color in which women were detected as having hypertension by ABPM while other ethnicities such as black and mixed women did not have this difference. The studies by Mendes et al. (2018) and Paula et al. (2020) discuss the differences between hypertensive and normotensive people when the topic is ethnicity or race Other demographic characteristics such as marital status and educational level did not show a statistical difference showing the presence or absence of hypertension when measured by the ABPM We also observed no significant differences in serum cardiovascular markers such as LDL, HDL, C-reactive protein, triglycerides or cholesterol between women with hypertension measured by ABPM and non-hypertensive women, also in this case the evaluation of cardiovascular markers was with average values (Babkowski et al., 2021). Kidambi et al. (2020) reported that The pulse wave velocity measure is a measure of arterial stiffness and there was no relationship with the detections of the presence of hypertension in women Our study has several strengths such as the assessment of many different variables–from demographic variables such as participants’ comorbidities and paternal and maternal comorbidities of the participants to anthropometric and serum dosage variables–to determine the presence of hypertension measured by the ABPM This study also serves to reinforce the use of the ABPM to measure hypertension in women aged close to 40 years to encourage future research and cohorts to investigate hypertension in this age group in women among the limitations of the study are that the women who underwent evaluation by ABPM were relatively few (n = 281) the acceptance of the placement of the ABPM voluntarily by women was low with only 281 accepting to do this specific evaluation Of the total of 929 women who participated in the cohort Another limitation is that these women were evaluated at a relatively young age (38–39 years) for the development of cardiovascular diseases it is consolidated in the literature that cardiovascular diseases appear more frequently in older age groups more specifically over 50 and over 60 years and the presence of hypertension during pregnancy are associated with arterial hypertension measured by ABPM We did not find this association for the other parameters analyzed in part because the women analyzed in the study were aged 39–39 years the identification of risk factors in women by ABPM is important for preventing future CVD reducing morbidity and mortality and improving quality of life and longevity The raw data supporting the conclusions of this article will be made available by the authors The studies involving human participants were reviewed and approved by The Ethics Committee of the University Hospital of the Ribeirão Preto Medical School approved this study under protocol number 45485915.7.0000.5440 The patients/participants provided their written informed consent to participate in this study The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Health in early adulthood: The contribution of the 1978/79 Ribeirão Preto birth cohort PubMed Abstract | CrossRef Full Text | Google Scholar Out of office blood pressure measurement in pregnancy and the postpartum period PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Burden of cardiovascular diseases attributable to risk factors in Brazil: Data from the “global burden of disease 2019” study PubMed Abstract | CrossRef Full Text | Google Scholar Camafort-Babkowski The global ambulatory blood pressure monitoring (ABPM) in heart failure with preserved ejection fraction (HFpEF) registry PubMed Abstract | CrossRef Full Text | Google Scholar Prevention and control of hypertension: JACC health promotion series PubMed Abstract | CrossRef Full Text | Google Scholar Relationship between blood pressure and anthropometry in a cohort of brazilian men: A cross-sectional study PubMed Abstract | CrossRef Full Text | Google Scholar de Siqueira Valadares Prevalence of metabolic syndrome in Brazilian adults in the last 10 years: A systematic review and meta-analysis PubMed Abstract | CrossRef Full Text | Google Scholar Hypertension defined by the 2017 ACC/AHA guideline is more accurate than 2018 ESC/ESH for detecting early vascular aging in young adults PubMed Abstract | CrossRef Full Text | Google Scholar Metabolic syndrome: Updates on pathophysiology and management in 2021 PubMed Abstract | CrossRef Full Text | Google Scholar Ambulatory blood pressure monitoring in children and adolescents: 2022 update: A scientific statement from the American heart association PubMed Abstract | CrossRef Full Text | Google Scholar Women’s cardiovascular health after hypertensive pregnancy: The long view from labor and delivery becomes clearer PubMed Abstract | CrossRef Full Text | Google Scholar The assessment of blood pressure in pregnant women: Pitfalls and novel approaches PubMed Abstract | CrossRef Full Text | Google Scholar Blood pressure reference values for Brazilian adolescents: Data from the study of cardiovascular risk in adolescents (ERICA study) PubMed Abstract | CrossRef Full Text | Google Scholar and type 2 diabetes: Results from two large human cohort studies PubMed Abstract | CrossRef Full Text | Google Scholar Twenty-four-hour versus clinic blood pressure levels as predictors of long-term cardiovascular and renal disease outcomes among African Americans PubMed Abstract | CrossRef Full Text | Google Scholar 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention and management of high blood pressure in adults: A report of the American college of cardiology/American heart association task force on clinical practice guidelines CrossRef Full Text | Google Scholar Prevalence of arterial hypertension according to different diagnostic criteria PubMed Abstract | CrossRef Full Text | Google Scholar Prevalence of arterial hypertension in Brazilian adults and its associated factors and activity limitations: A cross-sectional study PubMed Abstract | CrossRef Full Text | Google Scholar Association between perceived racial discrimination and hypertension: Findings from the ELSA-Brasil study PubMed Abstract | CrossRef Full Text | Google Scholar Hypertensive disorders of pregnancy: Definition and out-of-office blood pressure measurement PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Prevalence of the metabolic syndrome and its components in the Brazilian adult population PubMed Abstract | CrossRef Full Text | Google Scholar Identifying patterns of diurnal blood pressure variation among ELSA-Brasil participants PubMed Abstract | CrossRef Full Text | Google Scholar PubMed Abstract | CrossRef Full Text | Google Scholar Cardiovascular health in Brazil trends and perspectives PubMed Abstract | CrossRef Full Text | Google Scholar anthropometric variables and blood pressure in schoolchildren aged 10 to 18 years PubMed Abstract | CrossRef Full Text | Google Scholar 2020 international society of hypertension global hypertension practice guidelines PubMed Abstract | CrossRef Full Text | Google Scholar Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: A pooled analysis of 1201 population-representative studies with 104 million participants PubMed Abstract | CrossRef Full Text | Google Scholar Keywords: ambulatory blood pressure monitoring Sandrim VC and Cavalli RC (2022) Assessment by ABPM verified the presence of hypertension in patients with self-reported hypertension as well as differences between ethnicities in women aged 38-39 years in the Ribeirão Preto cohort Received: 12 July 2022; Accepted: 20 October 2022;Published: 09 November 2022 Copyright © 2022 Brandão, Veiga, Levy, Damaso, Sandrim and Cavalli. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Eduardo Carvalho de Arruda Veiga, ZWR1YXJkby52ZWlnYUBmbS51c3AuYnI= Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish Mattos Muriel Kestener has opened an office in Brazil’s agribusiness capital of Ribeirão Preto in the south-western state of São Paulo expert analysis and essential resources from the Latin Lawyer experts Copyright © Law Business ResearchCompany Number: 03281866 VAT: GB 160 7529 10 Get more from LLSign up to our daily email alert Unlock unlimited access to all Latin Lawyer content You have successfully subscribed to our newsletter addressed a crowd of guests and brand team members at the Hard Rock Cafe in Times Square to honor the brand's growth and usher in the upcoming opening of the new Hard Rock Hotel New York Hard Rock's new Messi merchandise and commercial were also debuted at the event offered Country Burgers for only US$0.71 during the first hour of business in honor of the year Hard Rock was founded while presenting guests with exciting activities including balloon displays Hard Rock Cafe also celebrated its anniversary by purchasing the building that houses the original Hard Rock Cafe London ensuring the preservation of the historic location where the brand started Numerous Hard Rock Hotel properties joined in to commemorate the anniversary by delivering treats to band members organizing a cleanup of the area around the hotel to ensure it remains safe and healthy putting on a special display of new merchandise and providing live music "Hard Rock's 50th anniversary is a huge milestone for the brand so we wanted to celebrate across our locations worldwide in a big way," said Jon Lucas Chief Operating Officer of Hard Rock International "Hard Rock is one of the world's most recognizable brands for entertainment gaming and leisure - a legacy which has been built over the last five decades We couldn't think of a better way to kick off this milestone than by announcing our first partnership with a true sports icon Hard Rock's LIVE GREATNESS campaign is built on the fan-focused principles that have guided Hard Rock since the opening of its first Cafe location in London in 1971 and aims to inspire fans while calling on them to unite under their love for the iconic entertainment and hospitality brand The campaign kicked off with new partnership between Hard Rock International and Lionel Messi and marks the brand's first deal with an athlete The collaboration pays homage to Hard Rock's roots as the brand's world-famous T-shirts came about when the original Hard Rock Cafe London sponsored a local soccer team in the 1970s Hard Rock and Messi have come together to unveil a new collection of merchandise which includes some of Messi's iconic symbols such as the number 10 the fourth unit of the international network in Brazil is located in Ribeirão Preto at Arena Eurobike in the Santa Cruz Stadium (Av and authentic American food is in operation following city and state ordinances The restaurant is open Tuesday through Sunday from noon to 3 pm and 5 pm to 10 pm and the Rock Shop on the same days from noon to 10 pm the Hard Rock Cafe Ribeirão Preto follows the rigorous developed by a team of specialists and in accordance with the recommendations of world health and sanitation authorities Comunicação social - todos os direitos reservados Research that can increase Brazil’s access to CAR T-cell therapy an increasingly important strategy for treating cancer is under way at the University of São Paulo’s Center for Cell-Based Therapy (CTC) in Ribeirão Preto and the Butantan Institute (image: NCI-NIH/Wikimedia Commons) By Theo Ruprecht  |  Agência FAPESP – Defense cells are removed from the patient, genetically reprogrammed in the laboratory and re-infused to combat cancer. This is chimeric antigen receptor (CAR) T-cell therapy. The strategy is as complex as it is promising. The good news is that the Center for Cell-Based Therapy (CTC) hosted by the University of São Paulo in Ribeirão Preto (Brazil) has achieved progress with more affordable treatment of this type and is investigating similar cell-based therapies “Since 2019, we’ve treated seven patients, all as compassionate cases, with CAR T-cell therapy developed at our center. The results have been positive, and we plan to do more research with a view to offering more affordable treatment nationwide,” said Rodrigo Calado one of CTC’s principal investigators and Scientific Director of the Ribeirão Preto Blood Center Brazil’s first CAR T-cell therapy for acute lymphoblastic leukemia and diffuse large B-cell lymphoma was produced by Novartis and approved in February by ANVISA Treatment of the same kind developed by Janssen-Cilag for multiple myeloma was approved in April In the United States these therapies cost around USD 400,000 The cost in Brazil has not yet been determined “We expect to be able to offer an alternative that costs between 10% and 15% of the current market price,” Calado said Genetic manipulation of T-cells requires appropriate infrastructure and advanced knowledge the Novartis therapy approved in Brazil entails deep-freezing of the cells for transportation to the United States where they are processed before returning to Brazil Shipping and processing costs are therefore high CTC is currently preparing for publication an article on the first compassionate cases treated at the institution “The most important message of this undertaking is that we’ve succeeded in developing a Brazilian technology to offer CAR T-cell therapy,” said Renato Cunha a researcher at CTC and head of the Bone Marrow Transplant and Cell-Based Therapy Service at the general hospital (Hospital das Clínicas) run by the Ribeirão Preto Medical School (FMRP-USP) The treatment is currently being validated with ANVISA we’ll begin clinical trials to obtain the necessary registrations,” Cunha said Clinical trials require a rigorous methodology a large number of volunteers and complex infrastructure funding has been provided by FAPESP under the aegis of its Science for Development Program One of the centers approved in the first Science for Development call is the Nucleus for Cell Therapy (NuTeC) one in São Paulo and the other in Ribeirão Preto,” Calado said The São Paulo building was opened in June 14 by Governor Rodrigo Garcia which hosts the Nucleus for Advanced Therapy (Nutera) Staffed by researchers from FMRP-USP and Butantan Institute the center plans to scale up production of CAR T-cells and other cell-based therapy products provide support for pre-clinical and clinical trials This infrastructure will enable CTC to comply with ANVISA’s requirements for clinical trials and large-scale production if the therapy is approved in future and to partner with other public and private institutions “The center provides a bridge between scientific knowledge and the supply of a therapy for the general public,” Calado said The facilities in Ribeirão Preto and São Paulo have the capacity to treat 300 patients per year “We want to become a hub for production of this type of cell CAR T-cells can produce highly positive responses even in advanced-stage patients after all other options have failed Guaranteeing access to this treatment is important for a country like Brazil,” Cunha said “Solid tumors in general produce molecules that promote local immunosuppression by inhibiting the action of conventional defense cells and CAR T-cells,” said Lucas Botelho de Souza These molecules are known as immune checkpoints The last decade has seen the development of immunotherapy drugs that inhibit these checkpoints considerably improving the treatment of several types of cancer sometimes the results aren’t as good as expected because the body’s natural T-cells may not recognize the disease as an enemy,” Botelho de Souza said researchers have studied the combined use of CAR T-cells with checkpoint inhibitors The idea is that the drugs remove the blockage put in place by the cancer while the cells lead an intense personalized attack on the target in question we were invited to review all the articles on the topic in order to compile the discoveries made to date,” Botelho de Souza said The review shows that under certain scenarios the combination has been capable of combating cancer in the laboratory and in some patients There’s been considerable variability,” Botelho de Souza said One possibility in the research conducted at CTC on both solid tumors and blood cancer is to construct CAR T-cells with different receptors and co-stimulators which could control the disease via different pathways “We’re also evaluating the effect of removing receptors from cells affected by cancer checkpoints,” he said it can be seen that the organism of patients who respond best to treatment with CAR T-cells exhibits higher levels of interleukins 17 and 23 CTC’s scientists have used this information to reprogram T-cells so as to stimulate production of these two interleukins the results are promising,” Botelho de Souza said “One of the challenges of combining multiple editions of CAR T-cells is preventing the immune system from becoming aggressive toward the patient,” Cunha said In both the product approved by ANVISA and the product to be used in CTC’s clinical trials the CAR T-cells include a personalized receptor and a co-stimulator protein “These are second-generation CAR T-cells,” he said Cunha is the coordinator of a consensus in the Brazilian Hematology Hemotherapy and Cellular Therapy Association (ABHH) that is concentrating on the use of CAR T-cells in Brazil “We’ve established principles for prescribing the treatment controlling side effects and producing the cells This shows Brazil has the maturity necessary to receive this type of technology and try to make it more affordable,” he said CAR T-cell therapy must use T-cells donated by the patient whose organism would reject cells from anyone else Sophisticated infrastructure is required to collect cells from identifying suitable patients to administering the treatment The patient may not have that long,” Cunha said To make the treatment more affordable and practicable researchers around the world are investigating genetic modifications to make CAR T-cells “universal” The goal is for a single line of T-cells to give rise to CAR T-cells for different patients Another possibility in trials to reach a universal treatment would be to use a different kind of defense cell scientists would perform genetic editing of natural killer (NK) cells which do not have this problem of incompatibility The method is known as CAR NK-cell therapy “It’s practicable and also appears to produce a safer inflammatory profile with less intense side effects,” Botelho de Souza said A CTC group led by Virginia Picanço-Castro, a professor at FMRP-USP, is developing different CAR NK-cells to see which ones have the most potential, and has published a review article on promising research results in the field “Little research involving humans is being done right now but it’s a matter of time,” Botelho de Souza said A drawback of CAR NK-cells is that they do not remain in the organism for very long and this could hinder long-term control of the cancer NK cell proliferation and conservation in the laboratory is particularly challenging Get quick access to your favorite articles Manage alerts on breaking news and favorite drivers Make your voice heard with article commenting Not even the heavy rain that came to Ribeirão Preto in the final hours of this Sunday morning got in the way of the great crowd that came to the street circuit located at the Industrial District and thousands of people could watch two great races in the second round of Brazilian Stock Car Championship The first double-header of the season brought two different winners and two different situations The first - and longest - race had the five-time champion Cacá Bueno beating pole sitter Max Wilson for his first victory in 20 months Next to him at the finish line were local hero Marcos Gomes and Julio Campos After a 40-lap-thriller which started with a wet track and the safety car holding everyone up for the first three laps the crowd could see battles going on everywhere on track Top-10 drivers would start race 2 in reverse grid position who came out of nowhere and made things more difficult Stock Car regulations determined that any change in the car between the heats should be penalized Many drivers changed tyres in the end of race one or at the beginning of race two But both Eurofarma-RC drivers Max Wilson and Ricardo Maurício changed tyres between heats - and were excluded by the race director from the first heat results The second race brought a mix of strategies and those who opted to change to slick tyres at the end of the first one took the lower risk the top ten had only two drivers using the Pirelli slicks: Tuka Rocha and Sérgio Jimenez - exactly the ones who finished in a one-two order Átila Abreu performed a stunning recovery to be the third driver to see the chequered flag It was a soul-cleansing victory which shows that I have the capacity and the talent to be here Tuka Rocha signed his contract with União Química/Bassani Racing only one week prior to the first race in Goiânia and his sponsorship contract is only up to the first six rounds of the season it was also Tuka’s first podium finish - and already with a win Marcos Gomes lost five points he scored on race two for leaving the pits with the boxes closed The official results of Brazilian Stock Car round two in Ribeirão Preto changed the Brazilian Stock Car Championship standings For entering the track with the pit lane closed (article 126.1 of Brazilian Motorracing Sports Code) Marcos Gomes was excluded from heat two results His five-points finish scored with a tenth place became zero and now Marcos Gomes dropped to second position on the championship with 31 points The championship is scheduled to April 26th at the Velopark track Cacá Bueno (winner of heat 1): "I bet the track was going to dry out before the end of race one and that strategy paid out We choose the dry-track setup and it was tough to keep up with Max and at the same time I had to save my rear tyres He opened a five-second gap and as soon I realized the gap wasn’t going to increase any further I decided it was the time to catch him up When it started to get really dry my setup worked better than his I made a move on turn 2 but he paid me back but afterwards he missed a breaking point I could go through Tuka Rocha (winner of heat 2): "It was a soul-cleansing victory which shows that I have the capacity and the talent to be here I hope this can be a turning point in my career so I can be here for a long time 80 - Marcos Gomes - Voxx Racing Team - + 1s4773 4 - Julio Campos - Prati-donaduzzi - + 9s3354 21 - Thiago Camilo - Ipiranga-RCM - + 13s5275 28 - Galid Osman - Ipiranga-RCM - + 28s4136 111 - Rubens Barrichello - Full Time Sports - + 29s7867 18 - Allam Khodair - Full Time Sports - + 30s6978 46 - Vitor Genz - Boettger Competições - + 31s1539 70 - Diego Nunes - Vogel Motorsport - + 36s89810 1 - Antonio Pizzonia - Prati-donaduzzi - + 41s86611 25 - Tuka Rocha - União Química Racing - + 1 lap13 8 - Rafael Suzuki - RZ Motorsport - + 2 laps14 110 - Felipe Lapenna - Schin Racing Team - + 2 laps15 2 - Rafa Matos - Schin Racing Team - + 2 laps16 51 - Átila Abreu - AMG Motorsport - + 2 laps17 3 - Bia Figueiredo - União Química Racing - + 3 laps18 14 - Luciano Burti - RZ Motorsport - + 4 laps19 26 - Raphael Abbate - Hot Car Competições - + 5 laps20 72 - Fábio Fogaça - Hot Car Competições - + 6 laps21 5 - Denis Navarro - Vogel Motorsport - + 7 laps22 12 - Lucas Foresti - AMG Motorsport - + 14 laps23 11 - Cesar Ramos - Cavaleiro Racing Sports - + 14 laps24 29 - Daniel Serra - Red Bull Racing - + 19 laps25 10 - Ricardo Zonta - Shell Racing - + 25 laps26 90 - Ricardo Maurício - Eurofarma RC - + 10s751*28 65 - Max Wilson - Eurofarma RC - + 17s353*29 83 - Gabriel Casagrande - C2 Team - + 31s574**30 77 - Valdeno Brito - Shell Racing - + 36s31431 88 - Felipe Fraga - Voxx Racing Team - + 1 lapFastest Lap: Rafa Matos - 1min12s136*Excluded by changing tyres after the end of race 1**Excluded for not going to the pits for a previous drive-through penalty 25 - Tuka Rocha - União Química Racing - 22 voltas em 30min22s2142 51 - Átila Abreu - AMG Motorsport - + 2s0424 5 - Denis Navarro - Vogel Motorsport - + 8s9065 14 - Luciano Burti - RZ Motorsport - + 11s3106 111 - Rubens Barrichello - Full Time Sports - + 15s6967 46 - Vitor Genz - Boettger Competições - + 15s7878 4 - Julio Campos - Prati-donaduzzi - + 16s5359 1 - Antonio Pizzonia - Prati-donaduzzi - + 17s03910 80 - Marcos Gomes - Voxx Racing Team - + 17s33011 83 - Gabriel Casagrande - C2 Team - + 17s74312 8 - Rafael Suzuki - RZ Motorsport - + 17s86213 18 - Allam Khodair - Full Time Sports - + 20s26314 28 - Galid Osman - Ipiranga-RCM - + 42s38915 70 - Diego Nunes - Vogel Motorsport - + 1 lap16 21 - Thiago camilo - Ipiranga-RCM - + 1 lap17 26 - Raphael Abbate - Hot Car Competições - + 2 laps18 11 - Cesar Ramos - Cavaleiro Racing Sports - + 10 laps19 0 - Cacá Bueno - Red Bull Racing - + 11 laps20 10 - Ricardo Zonta - Shell Racing - + 15 laps21 72 - Fábio Fogaça - Hot Car Competições - + 15 laps22 65 - Max Wilson - Eurofarma RC - + 15 laps23 90 - Ricardo Maurício - Eurofarma RC - + 15 laps24 74 - Popó Bueno - Cavaleiro Racing Sports - + 15 laps25 77 - Valdeno Brito - Shell Racing - + 15 laps26 12 - Lucas Foresti - AMG Motorsport - + 15 laps27 110 - Felipe Lapenna - Schin Racing Team - + 20 laps28 2 - Rafa Matos - Schin Racing Team - + 20 laps 3 - Bia Figueiredo - União Química Racing -31 29 - Daniel Serra - Red Bull Racing -Fastest Lap: Rubens Barrichello - 1min10s487 From Formula 1 to MotoGP we report straight from the paddock because we love our sport In order to keep delivering our expert journalism we want to give you the opportunity to enjoy an ad-free and tracker-free website and to continue using your adblocker CAR T-cell therapy offers hope for people with types of cancer that are hard to treat (illustration: CTC-USP) Nutera is Latin America’s first cellular product manufacturing plant It is run by researchers from Butantan Institute and the University of São Paulo’s Ribeirão Preto Blood Center into a supplier of products for advanced cell therapies The 81-patient Phase 1 and 2 clinical trial will confirm the safety and efficacy of the treatment for patients with B-cell acute lymphoid leukemia (ALL) and B-cell non-Hodgkin lymphoma (NHL) Approval is pending from the National Commission of Ethics in Research (CONEP) The volunteer profile will be established once its approval has been obtained The trial will take place free of charge at five hospitals in São Paulo state including the general and teaching hospitals run by the university’s medical school in Ribeirão Preto (Hospital das Clínicas/FMRP-USP) and the state capital (HC/FM-USP) “Approval of the trial is important as a step toward producing cellular products [cells altered in the laboratory] for the treatment of different kinds of cancer and other diseases. It’s the first time such complex products are to be distributed entirely in Latin America and a huge advance for the area of biotechnology,” said Dimas Covas head of the Ribeirão Preto Blood Center and principal investigator for the research project ANVISA has also authorized production of cellular products for the trial. The Ribeirão Preto Blood Center, USP and Butantan Institute are partnering in Nutera, which has received funding from FAPESP’s Science for Development Centers Program (read more at: agencia.fapesp.br/39048) applications can be made to ANVISA for permission to market cellular products “The manufacturing plant is a platform for manipulating genetically modified cells like CAR T-cells as well as viral vectors for gene therapy and cells derived from pluripotent stem cells The facility is on public land in a hospital that almost exclusively admits patients on the SUS but we have a research pipeline and will soon be producing second- and third-generation CAR T-cell products The clinical trial is just the start of a highly successful project,” Covas said The plant currently has the capacity to produce cells for 13 patients every 34 days “It’s not sufficient to meet all the demand from the SUS but we expect to be able to cater for 150 patients within a year and continue scaling up thereafter,” said Diego Clé medical director of the Ribeirão Preto Blood Center and one of the researchers involved T-lymphocytes (defense cells) will be collected from the volunteers and sent to the cellular product plant where the researchers will use bioengineering techniques to insert a viral vector gene sequence into the T-cells’ DNA The T-cells’ new DNA will express a receptor that was not there before and can recognize tumors which recognizes a specific protein in tumor cells a protein present in lymphoid leukemia and non-Hodgkin lymphoma cells,” Clé explained The genetically modified lymphocytes will be deep-frozen and sent back to the hospitals where the trial is being held “The patients will receive their new lymphocytes as if they were having a blood transfusion The CAR T-cells recognize the tumor and release a number of inflammatory mediators to attack it,” he said BV-FAPESP: research projects supported in this Center  CTC in the Media: news about the Center The Center for Cell-based Therapy (CTC) is made up of a group of researchers of USP and of the Regional Blood Center of Ribeirão Preto who are interested in understanding the biology of stem cells as well as in developing new technology for their use in the treatment of diseases The group of researchers engages physicians The researchers at CTC were responsible for the generation of the first embryonic stem cell line in Brazil and produced one of the first bovine and ovine clones in the country CTC researchers have an interest in signaling pathways of mammalian and human embryonic stem cells in animal and human adult cells reprogramming to the embryonic state of pluripotency (iPS cells) and in the functioning of adult stem cells From stem cells derived from healthy people CTC scientists investigate ways of producing blood components as an alternative source of blood transfusion other researchers use iPS cells derived from patients with blood disorders to better understand how these diseases happen and how they could be prevented or better treated researcher-physicians develop new methods of diagnosis and new treatment for leukemia CTC relies upon laboratories of cell and molecular biology and cell culture and inpatient units of hematopoietic stem cell transplantation in Ribeirão Preto Research conducted within the Cell Therapy Center USP (CTC) as to bring benefits to Brazilian society the possibility of obtaining more efficient medications divulged by the press and scientific journals we highlight the development of a platform for expanding genetically modified T cells for treating patients with leukemia and lymphomas; the discovery of the onset of X chromosome inactivation during human embryonic development; the advances in the treatment of systemic and multiple sclerosis; the new perspectives on fighting one of the most aggressive types of brain tumor astrocytoma; the inhibition of melanoma cells in culture; studies on telomeres; and the formation of a cell bank with the genetics of the Brazilian population