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Bangkok is not lacking in quantity and quality of amazing cosy cafes
although in the concrete jungle that the Thai megalopolis is
sometimes might be a bit difficult to find the combination of a beautiful cafe that gives you a peaceful and relaxed view and environment
In our continuous exploration to find the best hidden gems of the Thai capital
A beautiful cafe where you can sit outside just on the shoreline of Chao Phraya River
but hide from the buzz of noise and people of the city
as it is a little far from the city centre
If you choose to go there by public transport
you will have to take the Metro Blue Line to Bang Phlat (around 40 minutes ride from Asoke/Sukhumvit station) and then walk for another 10/15 minutes
The entrance when you reach nearby is also not so easy to spot
Your best reference is the big Lotus supermarket
Cross the ground floor and go to the backside where a huge parking space is
continue walking opposite direction from the supermarket to the river
Once you have completed this small “treasure hunt”
you will be rewarded with a cafe that owns some of the nicest views from the terrace from all Bangkok
The river on one side and a very cute small garden/terrace
you can of course shelter yourself inside the cafe building
The food options are nice but bear in mind that they only serve “Halal” food
I tried some Indian cuisine with Samosa and a curry plate
I was expecting the food to be a bit more tasty
At the entrance of the cafe you will also find some amazing cute details: a foosball table if you are up for a quick match and a zone that resembles a vintage garage
with some vintage Mercedes cars and motorbikes
All very picturesque and “instagrammable”
both the entrance and the river side of the cafe
Cafe page: https://www.facebook.com/Adamuscafe
10 Great tips for a date in Bangkok
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The first Transformer from the high-end alloy model series "Adamus Machina" featuring high detail and die-casting is "AMT-01 Rodimus"
who appeared in the Transformers: The Movie and other films
recreates the stylish proportions of both forms while achieving perfect transformation
A violent attack unfolded at Adamus Mines in the early hours of Thursday, December 12, 2024, when a group of heavily armed individuals, reportedly led by Isaac Ackun, an employee of BCM Ghana Limited, and Laurent Gaba, an illegal immigrant from Togo, and a stooge of Paul List stormed the mining facility.
According to eyewitness reports, the assailants forced their way onto the company’s premises, vandalizing equipment and infrastructure while attacking employees on-site.
Preliminary investigations suggest the attack was orchestrated in order to illegally take over the mining company which is owned by Angela List. Workers described the scene as chaotic, with property worth millions of cedis destroyed, including mining equipment, vehicles, and administrative offices.
The Western Regional Police Command has apprehended Isaac Ackun, Laurent Gaba and their accomplices and assisting with investigations.
Speaking to the media, a representative from Adamus Mines condemned the attack, describing it as a “premeditated and unlawful invasion.” He called on the government to ensure that justice is served and measures are put in place to prevent future attacks.
President of Lands & Mines Watch, an organization that promotes equitable mining and proper mining methods, Solomon Owusu has sounded a strong warning to any individual or entity seeking to illegally enter Adamus Resources and perpetrate fraud on Ghanaians. According to him, such attempts will be resisted vehemently with every sweat and blood.
Volume 8 - 2021 | https://doi.org/10.3389/fmed.2021.672444
This article is part of the Research TopicWomen in Science - Ophthalmology 2021View all 12 articles
Inherited retinal diseases (IRDs) are clinically and genetically heterogeneous rare disorders associated with retinal dysfunction and death of retinal photoreceptor cells
Among the most frequent and severe forms of those retinopathies is retinitis pigmentosa (RP) that affects 1:4,000 individuals worldwide
The genes that have been implicated in RP are associated with the proteins present in photoreceptor cells or retinal pigment epithelium (RPE)
Asymmetric presentation or sudden progression in retinal disease suggests that a gene mutation alone might not be responsible for retinal degeneration
Immune responses could directly target the retina or be site effect of immunity as a bystander deterioration
Autoantibodies against retinal autoantigens have been found in RP
which led to a hypothesis that autoimmunity could be responsible for the progression of photoreceptor cell death initiated by a genetic mutation
The other contributory factor to retinal degeneration is inflammation that activates the innate immune mechanisms
If autoimmune responses contribute to the progression of retinopathy
this could have an implication on treatment
we provide a perspective on the current role of autoimmunity/immunity in RP pathophysiology
The objective of this review is to provide a perspective on the current knowledge on the role of autoimmunity/immunity in retinal degeneration initiated by a genetic mutation
The retina consists of two types of photoreceptor cells, rods that are responsible for night vision, and cones for daytime vision and color vision. RP is characterized by degeneration of rods and cones caused initially by the gene mutations, typically affecting rods. Vision loss occurs when the primary rods deteriorate and are eliminated, which usually causes healthy cones to decline next, resulting in blindness (5)
The age of RP onset differs and depends on the gene mutations
The rod dysfunction affects the peripheral retina and loss of central vision is the consequence of cone dysfunction
it leaves rods mostly unaffected but can cause a severe loss of visual acuity and daylight vision
Early-onset RP is diagnosed when the symptoms of mid-stage RP are already present at 2 years of age and late-onset RP is diagnosed when the symptoms are clinically apparent at or after midlife
Thymic expression is a common feature for all the tissue-specific antigens and their levels of expression play a role in determining the susceptibility to autoimmunity against these molecules
The other contributory factor to retinal degeneration is inflammation that activates innate immune mechanisms, such as toll-like receptors, inflammasome receptors, and complement components that initiate complex cellular cascades by recognizing or sensing different pathogen and damage-associated molecular patterns (31, 32)
autoimmunity is likely to be responsible for the progression of photoreceptor cell death that was initiated by a defective gene
the degree of immune reactivity against arrestin and the severity of disease in the patients with RP are not strongly correlated
This observation suggests that the immune responses to the retinal autoantigens are regulated by factors other than the level of retinal damage and the release of antigens from the affected tissues
The systemic autoimmune responses may play a bigger role in formation of AAbs
These findings suggest that the presence of mutations and associated immune response could be part of the pathogenesis of RP
This suggests that inflammatory mediators as well as AAbs may contribute to the development of inflammatory CME
but the exact mechanism for the CME development and its persistence is still unknown
Further studies are needed to understand whether the HLA polymorphism influence the development of RP
Inherited retinal diseases represent a highly heterogeneous group of disorders that have one common element: abnormal visual function originating at the death of retinal photoreceptors. The gene defects can initiate death of retinal cells that can progress further to symptomatic changes mediated by immune and autoimmune responses (Figure 1)
An initial gene mutation followed by sudden loss and progressive nature of retinal degeneration suggests the involvement of autoimmune responses
Since there are a variety of genes and mutations that cause retinal degeneration
gene replacement therapy approaches that are currently in development may be time-consuming and cost-prohibitive for treatment of all forms of RP
If the autoimmune responses contribute to the progression of retinopathy this could have implication on development of retinal degeneration and success of gene replacement therapy
Alternative approaches can be based on the immunological pathways that cause retinal degeneration in different forms of RP
immunomodulatory and biologic drugs targeting B cells could be beneficial in slowing retinal degeneration caused by a gene mutation
More studies are needed to fully establish the role of autoimmunity in different forms of retinal degenerations
Schematic steps in progressive retinal degeneration
Mutant-proteins accumulate during retinal degeneration and can be seen as new
ultimately leading to autoimmune pathology
Activation of immune cells by overproduction of cellular debris due to photoreceptor death results in the inner Blood Retina Barrier (BRB) breakdown
which invites systemic macrophages into the retina
Resident and circulating macrophages can contribute to secondary retinal damage from inflammation
and in effect ameliorate retinal degeneration
The sole author is responsible for the design and writing of the review
This study was supported by grant P30 EY010572 from the National Institutes of Health (Bethesda
USA) and by unrestricted departmental funding from the Research to Prevent Blindness (New York
The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations
Any product that may be evaluated in this article
or claim that may be made by its manufacturer
is not guaranteed or endorsed by the publisher
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The mechanism of cone cell death in Retinitis Pigmentosa
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Challenge to the striking genotypic heterogeneity of retinitis pigmentosa: a better understanding of the pathophysiology using the newest genetic strategies Eye
Toward an elucidation of the molecular genetics of inherited retinal degenerations
Next-generation sequencing identifies unexpected genotype-phenotype correlations in patients with retinitis pigmentosa
Photoreceptor cell death mechanisms in inherited retinal degeneration
Retinitis pigmentosa: genes and disease mechanisms
multifocal ERG and multifocal VEP in patients with retinitis pigmentosa and residual central visual fields
Yearly rates of rod and cone functional loss in retinitis pigmentosa and cone-rod dystrophy
Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration
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Are anti-retinal autoantibodies a cause or a consequence of retinal degeneration in autoimmune retinopathies
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Mechanisms of blood-brain barrier breakdown
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Definition of human autoimmunity - autoantibodies versus autoimmune disease
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Ocular antigen does not cause disease unless presented in the context of inflammation
Clinical evidence of sustained chronic inflammatory reaction in retinitis pigmentosa
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Autoimmune retinopathy in the absence of cancer
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Autoantibodies against retinal proteins in paraneoplastic and autoimmune retinopathy
Latest updates on antiretinal autoantibodies associated with vision loss and breast cancer
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Occurrence of major anti-retinal autoantibodies associated with paraneoplastic autoimmune retinopathy
Progress toward precisely diagnosing autoimmune retinopathy
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Outcomes in autoimmune retinopathy patients treated with rituximab
Activated microglia in human retinitis pigmentosa
Microglia in the healthy and degenerating retina: Insights from novel mouse models
Persistent inflammatory state after photoreceptor loss in an animal model of retinal degeneration
Autoimmunity and the clearance of dead cells
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Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment
Apoptotic photoreceptor cell death in mouse models of retinitis pigmentosa
Mechanisms of apoptosis in retinitis pigmentosa
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Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration
Bax-induced apoptosis in leber's congenital amaurosis: a dual role in rod and cone degeneration
Protective effect of clusterin on rod photoreceptor in rat model of retinitis pigmentosa
NLRP3 inflammasome activation drives bystander cone photoreceptor cell death in a P23H rhodopsin model of retinal degeneration
Autophagy is one of the multiple mechanisms active in photoreceptor degeneration
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Autophagy supports survival and phototransduction protein levels in rod photoreceptors
Autophagy dysfunction and oxidative stress
two related mechanisms implicated in retinitis pigmentosa
Autophagy-mediated catabolism of visual transduction proteins prevents retinal degeneration
Programmed cell death in retinal degeneration: targeting apoptosis in photoreceptors as potential therapy for retinal degeneration
The molecular and cellular basis of rhodopsin retinitis pigmentosa reveals potential strategies for therapy
Expression profile of IL-1 family cytokines in aqueous humor and sera of patients with HLA-B27 associated anterior uveitis and idiopathic anterior uveitis
Intraocular cytokine profile and autoimmune reactions in retinitis pigmentosa
Multiple cytokine analyses of aqueous humor from the patients with retinitis pigmentosa
Large cell neuroendocrine carcinoma of the lung with cancer-associated retinopathy
Autoimmune responses against photoreceptor antigens during retinal degeneration and their role in macrophage recruitment into retinas of RCS rats
Review: retinal degeneration: focus on the unfolded protein response
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C-Reactive protein and progression of vision loss in retinitis pigmentosa
Natural antibodies bridge innate and adaptive immunity
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Natural IgG autoantibodies are abundant and ubiquitous in human sera
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Immune reactivity to different retinal antigens in patients suffering from retinitis pigmentosa
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Clinical studies: antiretinal antibodies and fluorescein angiogram findings
Immune responsiveness to retinal S-antigen and opsin in serpiginous choroiditis and other retinal diseases
Serum anti-recoverin antibodies is found in elderly patients with retinitis pigmentosa and cancer
Immune response to retinal antigens in patients with gyrate atrophy and other hereditary retinal dystrophies
Evolution time and longitudinal studies of the anti-S-antigen antibody titers in retinitis pigmentosa
Anti-retinal S-antigen antibodies in human sera: a comparison of reactivity in ELISA with human or bovine S-antigen
Disease progression in patients with dominant retinitis pigmentosa and rhodopsin mutations
The molecular organization of human cGMP specific phosphodiesterase 6 (PDE6): structural implications of somatic mutations in cancer and retinitis pigmentosa
and translational immunology approaches reveal mutated forms of Proteolipid Protein 1 (PLP1) and mutant-specific immune response in multiple sclerosis
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and promotion of anti-retinal autoimmunity: intersecting paths in retinal degenerations of potential therapeutic relevance
Proinflammatory pathways are activated in the human Q344X rhodopsin knock-in mouse model of retinitis pigmentosa
Single nucleotide polymorphisms as a prerequisite for autoantigens
Autoantigens act as tissue-specific chemoattractants
A common repertoire of autoantibodies is shared by cancer and autoimmune disease patients: inflammation in their induction and impact on tumor growth
Autoantigens signal through chemokine receptors: uveitis antigens induce CXCR3- and CXCR5-expressing lymphocytes and immature dendritic cells to migrate
Negative regulation of lymphocyte activation and autoimmunity by the molecular adaptor Cbl-b
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Is there an association of anti-retinal antibodies and cystoid macular edema in patients with retinitis pigmentosa
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HLA-DQB1*0201/0302 is associated with severe retinopathy in patients with IDDM
An association between acute retinal necrosis syndrome and HLA-DQw7 and phenotype Bw62,DR4
Human retinal pigment epithelial cells differentially express MHC class II (HLA
DR and DQ) antigens in response to in vitro stimulation with lymphokine or purified IFN-gamma
Endogenous systemic IFN-gamma has a protective role against ocular autoimmunity in mice
Number of hyperreflective foci in the outer retina correlates with inflammation and photoreceptor degeneration in retinitis pigmentosa
and Age-Related Macular Degeneration: A Minireview
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Retinal microglia: just bystander or target for therapy
Early microglia activation precedes photoreceptor degeneration in a mouse model of CNGB1-linked retinitis pigmentosa
Microglia activation in retinal degeneration
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Photoreceptor proteins initiate microglial activation via toll-like receptor 4 in retinal degeneration mediated by all-trans-retinal
Targeting the complement system for the management of retinal inflammatory and degenerative diseases
C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa
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Complement system dysregulation and inflammation in the retinal pigment epithelium of a mouse model for Stargardt macular degeneration
Minocycline inhibition of photoreceptor degeneration
Citation: Adamus G (2021) Importance of Autoimmune Responses in Progression of Retinal Degeneration Initiated by Gene Mutations
Received: 11 May 2021; Accepted: 01 November 2021; Published: 02 December 2021
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provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited
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distribution or reproduction is permitted which does not comply with these terms
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Adamus Resources Limited has refuted recent claims regarding the existence of an Interim Management Committee (IMC) at its Nzema Mine
emphasizing that the High Court has rendered such assertions baseless and void
clarified misinformation circulated allegedly by Allan Morrison
alleged that an IMC had been denied access to the Nzema Mine after an attempted entry
But Adamus Resources insists these reports are untrue and misleading
by Her Ladyship Justice Jennifer Abena Dadzie
Justice of the Court of Appeal sitting as an additional High Court Judge
it was determined that all pending interlocutory applications and orders had lapsed
which the alleged IMC has reportedly been using to substantiate its claims
The ruling followed an application by lawyers for Adamus Resources Limited and Nguvu Mining Ltd to withdraw a suit
a prior ruling by Justice Loddoh had dismissed counterclaims brought by Allan Morrison and Adamus Resources Pty Ltd
“This ruling confirms that there is no Interim Management Committee at Adamus Resources Limited,” the company stated
“The false claims and subsequent media reports have no legal or factual basis.”
The company questioned the motives behind the misinformation and urged media outlets to verify facts before publication
“These unfounded reports have the potential to harm the company’s operations and reputation,” it warned
Adamus Resources assured stakeholders that any official communication would come from its communications bureau on the company’s official letterhead
The public was advised to disregard claims about an IMC and treat them “with the contempt they deserve.”
The company emphasized its commitment to transparency and urged media outlets to report responsibly
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Source: Mercy Mensah
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The Interim Management Committee (IMC) appointed by the Accra High Court of Justice in July 27
is facing significant challenges in executing its mandate
the security personnel at the company’s operational site in Ellembelle have denied the IMC access to take over the management of the company
This isn’t the first time the IMC has been prevented from carrying out its duties
they’ve been blocked from entering the company’s premises
including the Head Office in Accra and the operational site in Ellembelle
The IMC was established due to ongoing disputes over the ownership of Adamus Resources Ltd
The court’s order aimed to ensure the company’s operations continue uninterrupted while the legal battles are resolved
Member of the committee Isaac Ackon has reaffirmed the IMC’s commitment to executing its mandate
“The committee is determined to fulfill its duties as directed by the court.”
A gunshot was fired by security personnel of Adamus Resources Limited
a mining company in the Ellembelle District
as they denied access to the Interim Management Committee (IMC) appointed by the Accra High Court
The IMC was established to oversee the mine’s operations temporarily
the company’s management and security team have repeatedly blocked the IMC’s attempts to take control of the mine
Thanks to the professional intervention of Inspector Danquah and his police team stationed at the mine
and the situation was brought under control
The Interim Management Committee (IMC) members and their private security personnel were able to leave the mine peacefully
without any damage or destruction of equipment
This contradicts earlier reports on some news portals that thugs had attacked Adamus Resources
The swift and effective response of Inspector Danquah and his team helped to prevent escalation and ensured a peaceful resolution
some workers at the mine expressed their desire for the original owner
They cited significant struggles since a new company took over
including delayed salary payments and inadequate provision of essential work equipment
The workers lamented that the new company has failed to invest in new equipment
instead relying on outdated machinery that was already in place when she assumed control
This lack of investment has seemingly hindered the mine’s productivity and affected the workers’ overall welfare
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Source: Okine Isaac
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Adamus Resources Limited (ARL), based in the Western Region, has called on the Minister of Lands and Natural Resources, Emmanuel Armah Kofi Buah to, as a matter of urgency, intervene and help halt all illegal mining activities in the area, particularly, on its concession.
ARL is a gold mining company at Ellembelle in the Nzema enclave of the Western Region.
Adamus Resources has expressed concern over illegal mining activities on its concessions at the company’s Nzema Gold Project.
The mining company asserted that the illegal mining activities, also called ‘galamsey,’ is being spearheaded by the Evalue-Ajomoro Gwira Constituency Chairman of the National Democratic Congress (NDC), Emmanuel Annor-Kwofie and his alleged counterparts.
The company has, therefore, called for a halt of the illegal activities in order to help save the water bodies in the area, particularly the Ankobra River.
In a petition dated Wednesday, February 12, 2025, the company wondered why the NDC Constituency Chairman should embroil himself in galamsey activities just a month after his party took over power.
The company has also written letters signed by Adamus Resources Nzema Gold Operations General Manager, Kwadwo Opoku Ansah, to the Regional Police Commander and copied to all regional and national stakeholders on the issue.
The company accused Annor-Kwofie of collaborating with his alleged Chinese counterparts in the illegal activities, adding that they are already on the verge of destroying the Ankobra River’s banks as well as sections of the Gwira enclave’s virgin forest.
Adamus Resources further stated that the ongoing galamsey actions at Akango North in the Nzema area, are negatively impacting its operations despite several attempts to cease it.
“The company is not able to stop the activities due to the sophisticated weapons the men guarding Mr. Annor-Kwofie’s employees are wielding.
“The constituency chairman is known to have launched other operations in localities such as Amgbasie, Duale, Awulezu, and Kukwaville, all of which are located in the Gwira and Ajomoro enclave of Nzema East Municipality of the region,” the statement noted.
It said several stakeholders have expressed deep concern about Annor-Kwofie’s alleged notorious behaviour, which started immediately after the NDC won the 2024 general elections.
According to some traditional, opinion leaders and party members, the NDC Chairman’s actions contradict President John Dramani Mahama’s campaign promise to protect water bodies and forest reserves.
The management of Adamus Resources claim that Annor-Kwofie’s actions are damaging to their operations, necessitating immediate government intervention.
They have also urged the party’s leadership to implement measures to punish Mr. Annor-Kwofie, to dissuade others from engaging in similar conduct.
Meanwhile, the Health, Safety, and Environment Manager of Adamus Resources, Philip Thompson, has confirmed that police in the Nzema area on Friday embarked on an operation to help halt the illegal mining activities. However, the situation has not changed.
Efforts by DAILY GUIDE to get Mr. Annor-Kwofie’s side of the story were not successful, as he failed to pick calls from the paper and did not respond to WhatsApp message sent to him.
Volume 8 - 2017 | https://doi.org/10.3389/fimmu.2017.00505
This article is part of the Research TopicRegulation of Inflammation in Chronic DiseaseView all 48 articles
Autoantibodies (AAbs) against glycolytic enzymes: aldolase
and pyruvate kinase are prevalent in sera of patients with blinding retinal diseases
such as paraneoplastic [cancer-associated retinopathy (CAR)] and non-paraneoplastic autoimmune retinopathies
as well as in many other autoimmune diseases
CAR is a degenerative disease of the retina characterized by sudden vision loss in patients with cancer and serum anti-retinal AAbs
we discuss the widespread serum presence of anti-glycolytic enzyme AAbs and their significance in autoimmune diseases
There are multiple mechanisms responsible for antibody generation
including the innate anti-microbial response
or autoimmune response against released self-antigens from damaged
and aldolase exist in a single patient in elevated titers
suggesting their participation in pathogenicity
The lack of restriction of AAbs to one disease may be related to an increased expression of glycolytic enzymes in various metabolically active tissues that triggers an autoimmune response and generation of AAbs with the same specificity in several chronic and autoimmune conditions
the importance of serum anti-glycolytic enzyme AAbs had been previously dismissed
but the retina may be without pathological consequence until a failure of the blood–retinal barrier function
which would then allow pathogenic AAbs access to their retinal targets
blocking cellular functions of glycolytic enzymes by pathogenic AAbs could be devastating to any cells’ survival
Schematic representation of the glycolytic pathway and anti-enzymatic protein autoantibody involvement
glyceraldehyde-3-phosphate dehydrogenase; GPI
Diagram of the eye and the organization of retinal layers and cells showing H&E staining of representative section of human retina
To understand the role of glycolytic enzymes as target autoantigens
it is important to appreciate their biological significance in retinal disease and other autoimmune conditions
This review is an attempt to explain the high frequency of AAbs against glycolytic enzyme association in autoimmune diseases
The study suggested that these AAbs may be involved in the induction of cardiac autoimmune diseases
The linking of epitopes to specific autoimmune and inflammatory conditions is a challenge
so more research is needed to decide whether enzymatic protein epitopes would better distinguish their association with a particular disease and have a causative activity
Aldolase C interacts with GAPDH and catalyzes GAPDH inactivation in the presence of extracellular signals, indicating that such a complex has a regulatory function (73). In addition, aldolase strongly interacts with cytoskeletal elements. Aldolase A has also been found in the nucleus of many types of tumors, and is involved in the regulation of cell proliferation (74, 75)
In spite of association of serum anti-glycolytic enzyme AAbs with many of those diseases
it is not clear whether such AAbs are the direct result of
or are made due to the released antigenic proteins from damaged cells
including failing photoreceptors in the retina during progression of macular degeneration in AMD or AR
All of these findings suggest that AAbs can adversely contribute to retinal and neuro-axonal degeneration
Widespread occurrence of autoantibodies (AAbs) against glycolytic enzymes with pathogenic properties in autoimmune diseases
anti-enolase AAbs have a potential to induce retinal degeneration
not only by the local formation of immune complexes but also by the direct damage to retinal cells and influence their cell function
The most common sources regarding AR treatment benefits are published case reports. For example, a brief course of oral corticosteroids in a patient with anti-enolase AAbs caused an improvement in visual fields, disappearance of enolase-α AAbs, partial recovery of the cone response, and complete recovery of the rod response as measured by ERG (124)
These findings suggest a pathologic role for enolase-α AAbs in this autoimmune rod/bipolar cell dysfunction
In another study, the authors report that anti-GADPH can cross the placenta (125). A seropositive patient with AR and severe myasthenia gravis (MG) experienced a rapid progression of vision loss from driving vision to the hand motion/light perception level over 2-year period (125)
The patient then underwent weekly plasmapheresis therapy
which led to an improvement of her symptoms
She became pregnant during the course of treatment
peripheral blood was collected from mother
Both samples were seropositive for anti-GAPDH among other AAbs
Despite the presence of those AAbs in the cord blood
the 6-month old patient appeared to have developed normal visual function and no MG symptoms
The number of AR patients benefited from rituximab treatment (128–131). The efficacy of rituximab was studied in six patients (12 eyes) administrated as a monotherapy or in combination therapy (132)
Some patients in the study had anti-enolase (three patients) and anti-aldolase (one patient) AAbs
Stabilization and/or improvement of visual acuity
and electroretinography parameters were observed in 75% of patients treated with rituximab
and AR are characterized by persistently elevated levels of ant-retinal AAbs
B cell depletion therapy based on rituximab delivers promising therapy for those patients
larger scale studies of should be pursued in the future
the serum presence of anti-glycolytic enzyme AAbs
whose importance had been previously dismissed
might be without pathological consequences until a failure of the BRB function
in effect allowing pathogenic AAbs access to their retinal targets
Because of the presence of AAbs with several specificities in a single patient
might be responsible for degenerative processes in AR
A possible mechanism for the generation of anti-glycolytic proteins antibodies and their role in the induction of the retinal disease process
Antibodies that are generated as a result of tumor
or cell turnover during inflammation may target common antigens (the same specificity antigens) in the retina
Such antibodies can be present in the serum for a long time before clinical presentation of disease occurs
Degenerating tissue can be a source of new antigens that can initiate the further expansion of autoantibodies (AAbs) production and acceleration of disease
The author was totally the sole responsible for the design and writing of this review article
This work was supported by grant P30 EY010572 from the National Institutes of Health (Bethesda
USA) and by unrestricted departmental funding from research to prevent blindness (New York
Anti-enolase alpha autoantibodies in cancer-associated retinopathy: epitope mapping and cytotoxicity on retinal cells
The role of anti-alpha-enolase autoantibodies in pathogenicity of autoimmune-mediated retinopathy
Alpha-enolase: a target of antibodies in infectious and autoimmune diseases
Seroreactivity against glycolytic enzymes in inflammatory bowel disease
Inflamm Bowel Dis (2011) 17:557–64
Autoantibody signatures involving glycolysis and splicesome proteins precede a diagnosis of breast cancer among postmenopausal women
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
Annu Rev Cell Dev Biol (2011) 27:441–64
and shuttling of metabolites in vertebrate retinas
The cellular and compartmental profile of mouse retinal glycolysis
Cancer-like metabolism of the mammalian retina
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Citation: Adamus G (2017) Impact of Autoantibodies against Glycolytic Enzymes on Pathogenicity of Autoimmune Retinopathy and Other Autoimmune Disorders
Received: 31 January 2017; Accepted: 12 April 2017; Published: 28 April 2017
Copyright: © 2017 Adamus. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
provided the original author(s) or licensor are credited and that the original publication in this journal is cited
*Correspondence: Grazyna Adamus, YWRhbXVzZ0BvaHN1LmVkdQ==
Source: www.ghanaweb.com
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Angela List
Chief Executive Officer(CEO) of Adamus Resources Limited
Aerospace Engineering student Spencer John has translated his lifelong love of space into a significant accomplishment: publishing a paper in an academic journal as an undergraduate student
“To be published as an undergrad makes me extremely proud,” said John
an Embry-Riddle Aeronautical University senior
I’m incredibly thankful to all of the people involved with the paper
and for how fortunate I am to be at a college where this opportunity is available.”
The paper
which appeared in the journal Acta Astronautica earlier this month
presents research undertaken to help solve the problem of debris — such as defunct spacecraft and rocket bodies — in space
Although extensive efforts are under way to slow the accumulation of such debris
many studies have suggested a need for actively removing the largest abandoned objects orbiting the Earth
professor of Aerospace Engineering and also an author on the paper
said the Acta Astronautica paper looks at characterizing debris objects in orbit from an operational spacecraft
calculating the objects’ size and motion
so they can be safely removed to “maintain future access to orbital regimes of vital importance.”
a sensing method that employs pulsed laser light to measure distances
to construct a 3D model of the debris object
“and from there uses first principles to estimate rotational and translational motion and mass properties.”
Pol Fontdegloria Balaguer, another senior in Aerospace Engineering, is also an author on the published paper. He explains that Bevilacqua welcomed him into his ADAMUS (ADvanced Autonomous MUltiple Spacecraft) lab in the fall of 2021
increasing his level of responsibility over time
Bevilacqua has encouraged me to get involved in more and more research
and he has always recognized my work in the lab,” Fontegloria Balaguer said
adding that he did not anticipate being published while an undergraduate.
“I did not expect this work to be recognized so early in my career,” he said
Bevilacqua has ensured that my contributions to the team do not go unnoticed.”
Fontdegloria Balaguer, who will pursue a master’s degree in Aerospace Engineering with a concentration in Dynamics and Controls
said being involved in research at the ADAMUS lab has given him invaluable experience
“It gives me a perspective of group and work dynamics that cannot be taught in class,” he said
it has given me the opportunity of working with different hardware
it has also given me the opportunity to manage responsibility
and making decisions on how to conduct experimentation.”
John said being involved in the research has been immensely helpful to his development as an engineer
as he develops his design and CAD (computer-aided design) work so he can one day work as a designer for a rocket company
“Being involved in this research will help me immensely in my career path
to a point where I can’t even describe how much
I have been able to experience the fun part of engineering
working pieces of equipment,” John said
he had “vastly” broadened his knowledge by reading many other journal papers
learning about electrical engineering and how to wire robots
as well as learning how to work the interface of a Raspberry Pi computing and programming device
“I have grown in so many ways and would argue that my experience with research has prepared me better than almost any class,” John said
Posted In: Engineering | Research | Space
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Minister for Lands and Natural Resources
Dr. Riccardo Bevilacqua, professor of Aerospace Engineering at Embry-Riddle Aeronautical University
has published an article in the AIAA Journal that opens a new path to predicting the behavior of fragmentation from explosive warheads
The recent publication, which also lists one of Bevilacqua’s Ph.D. students as an author, is an example of the success that the professor, who was recently named Researcher of the Year by Embry-Riddle’s College of Engineering
has had in publishing — and in providing his students a platform on which to participate in major projects
“I'm not saying I wouldn't be successful without Dr
but I definitely wouldn't be where I am right now.”
Bevilacqua has secured research funding of more than $1 million
students and two undergraduate researchers to participate in his projects
and he is the principal investigator or co-investigator on several pending research proposals
A nominating statement for the Researcher of the Year award said
“all his resident students and visiting researchers end up publishing in top journals,” adding that he has “created an atmosphere of collegiality and friendship” within his research group
"Riccardo’s research program highly engages doctoral students
offering immense value through research exposure and direct contribution to the discovery of process knowledge," said Jeremy Ernst
vice president for research and doctoral programs
Bevilacqua’s work not only has disciplinary impact but provides meaningful experiences that shape the research agendas of future scholars."
Bevilacqua has done for all of his students is see the potential in us that we sometimes don’t see ourselves
He pushes us to reach that potential and does the most for each one of us to make sure we each have everything we need to succeed.”
Kinzie in May won a NASA Space Technology Graduate Research Opportunities fellowship
which comes with an $84,000 renewable grant
Bevilacqua is the one who tasked me with working on gravity recovery missions
which ultimately led to me receiving the graduate fellowship with NASA
He is the one who pushed me to apply for the fellowship in the first place.”
Ph.D. student Nicolo Woodward, who first studied with Bevilacqua at the University of Florida and then followed him to Embry-Riddle, was selected last year to receive funding from a GAANN (Graduate Assistance in Areas of National Need) grant
Woodward said Bevilacqua’s mentorship has had “a huge impact on my educational career and made me the engineer and researcher I am today
Thanks to him I was exposed at an early age to complex projects where I have gained invaluable experience in the design
testing and assembling processes of building small spacecraft.”
Recent graduate Pol Fontdegloria, who will begin an Aerospace Engineering master's at Embry Riddle in the fall
said Bevilacqua provided him the opportunity to work with aerospace hardware in open-ended projects
“taking me out of my comfort zone and providing me with valuable experience that will help me in my future career
Bevilacqua's work and passion for engineering motivated me to keep pursuing my education after graduation and keep doing research with him.”
Along with Fontdegloria, recent graduate Spencer John had a paper published with Bevilacqua on the topic of space debris removal in the journal Acta Astronautica
Being published as undergraduates was a significant
John said that working with Bevilacqua allowed him to apply classroom knowledge to actual hands-on work
“From spacecraft simulators to the Helmholtz cage
Bevilacqua’s lab introduced me to different ideas and equipment that I likely would have never experienced otherwise,” John said
adding that Bevilacqua’s mentorship went beyond the immediate research
B helped me grow as both an engineer and a person
When I was approaching graduation and beginning my job search
“I am forever grateful for not only the chance to work academically with him
but also the opportunity to meet and build a connection with such a polished
Posted In: Engineering | Research
Volunteering in the Cleveland community and serving others is what matters most to Vickie Adamus
she even planned for this in her retirement
After working for over 35 years as a school teacher
Vickie set her heart on supporting Cleveland and its residents
ranging from providing entertainment to basic needs
The Greater Cleveland Food Bank (GCFB) has appreciated Vickie's volunteer efforts
especially now – during the COVID-19 pandemic
Vickie is supporting the development department
by sending external communication and ways to support the GCFB
Vickie volunteered in the kitchen by completing food data entries
and would fill-in whenever the GCFB needed extra help
Vicki would help cover administrative duties as a receptionist
it is no surprise why Vickie is one of GCFB's favorite volunteers
Vickie has also volunteered with Destination Cleveland
which drives economic impact through leisure and business travel experiences
She was previously active with hosting large-scale conventions and events
One of the last major events she supported was the MLB All-Star Game
where she directed volunteers as a Team Captain and supported the arrival of guests
She also volunteered with incoming Cleveland crew ships by greeting visitors
Vickie has volunteered with Playhouse Square and the Cuyahoga Valley Scenic Railroad
She volunteers twice a month with Playhouse Square as a redcoat usher
she volunteers with Scenic Event Trains and Polar Express
The Scenic Event Trains have volunteers like Vickie who can aid in concessions
Vickie dresses up as an elf and engages with many children
Polar Express elves read children's stories
and entertain children until Santa arrives
coaches and support staff wore shirts with the Browns Give Back logo featured
coaches and support staff wore shirts with the Stay in the Game
coaches and support staff wore shirts featuring the phrase 'Sanction Girls Flag'
and University Hospitals also created a Care Closet at Arbor Elementary School
Collinwood Athletic Complex project marks the 16th field dedicated by the Browns
Browns continue their efforts to help sanction girls flag football in Ohio
About 300 athletes participated in combine-style testing and position-specific drills
Browns and NEOMED packed reading kits and read to students
Students from Garfield Heights City Schools attended panel conversation with Browns employees to learn about career opportunities in sports
Over 400 participants attended the clinic at CrossCountry Mortgage Campus
Northeast Ohio Flag Football and the Browns helping grow high school girls flag football
particularly those in the Ellembelle District of the Western Region have commended the Chief Executive Officer (CEO) of Adamus Resources Limited
for having the development of the area at heart
They have therefore resolved to give the CEO
the requisite support to continue her good works geared towards creating employment opportunities and providing a livelihood for the youth
they called on the people of Nzema to disregard any report suggesting that some sections of the youth
are against the leadership style of the CEO
Hundreds of the Nzema Youth and some employees of the mining company
yesterday poured onto the streets in their numbers for a peaceful march to throw their unflinching support behind the CEO
our teachers now have accommodation near our school
“Teleku-Bokazo has clean water and good sanitation because of you” and “Angela values education
Anwiah community appreciate your efforts” among others
The youth also mentioned other projects undertaken by Adamus under the leadership of the CEO as the renovation of the administration block of Nkroful Agriculture Senior High School and women empowerment programme
indicated that despite the challenges the company is currently facing
Madam List has been taking good care of the workers
The Assembly member for the Nkroful electoral area
Francis Kwaw Mensah explained that Adamus Resources Limited is 90% owned by Adamus Australia while the government of Ghana owns the remaining 10% shares
he gathered that Nguvu Mining Limited registered in Mauritius claimed to have acquired the 90 percent shares in the company from Adamus Australia and the alleged claim had resulted in a purported dispute
Under the distinct leadership of the CEO Madam Angela List
the company has embarked on numerous developmental projects that have helped to improve the lives of the people
“The CEO has introduced Women Empowerment (WE) Project where 87 females in the Ellembelle District have obtained skills under College of Beauty Arts and Entrepreneurship (CBAE)
The project seeks to equip the women with employable skills,” he said
Nathan Adamus is accustomed to using his writing skills to tell stories about the world's top athletes and biggest sporting events
The Elmira native has been an editor and writer for a national publication chronicling the history of the Super Bowl and did the same for a magazine looking at the best the NBA has to offer
Now he has turned his focus to writing about a tree
If you're an old-school NBA fan wondering if his newest subject is Tree Rollins
it's actually a collaboration with his mother
is titled "The Story of the Whistler Tree" and has a universal message that ties into the purpose of that tree and the characters in the book
wanted to write something that would inspire children after Souza Family Books
to not follow somebody else's path," said Adamus
she has her wool and that helps make stuff
Everybody has their own thing that makes them happy
it's just a story of figuring out what makes you happy."
Adamus is a 1995 graduate of Elmira Notre Dame High School whose extensive writing background also includes contributing to a magazine focused on the history of the NCAA men's basketball tournament
He has written for magazines that covered topics such as encounters with Jesus
a company geared toward web content and development
has been part of some of these publications
an artist who received the 2015 Elmira Regional Art Society Palette Awards People's Choice Award for her watercolor
NY." The book is illustrated throughout with drawings from Mary Adamus chronicling the story and the tree
It was Nathan's idea to have his mom lend her expertise
'These are the images we're looking for.' Kind of build off that
She does a very good job of getting an idea of what we're trying to give her."
Nathan said one similarity the book shared with his sports ventures is he had to figure out how to make the topic interesting to its intended primary audience — in this case
with that background paying off when he decided to tell the tree's story through prose
The Whistler Tree's story starts as a seed that wanders from its parents after falling to the ground
The Whistler gets help from forest animals and has a chance meeting with a little girl as it grows to learn its life purpose
Nathan already has heard back from people who said the book's message is one that resonates
"Somebody actually contacted me and said the story is extremely inspirational," he said
I think so many children's books these days kids can enjoy
but they don't have that message that was so prominent in books when we grew up
Mary Adamus said she collaborated with her son over the phone and used various sources of inspiration for the illustrations
including research on the tree and old pictures of her niece that served as the model for the girl in the book
'Do you really think you can do this?'" she said
How else do you know.' I said it would be silly for me not to try
'My son wrote the story and I wouldn't try to do the illustrations?' If they like them
Mother and son were thrilled to have had the chance to work together and to help pass on a meaningful message
"I feel it's the hand of God with me in the paintings and the drawings
then with the help of other people like Wilson Ong and Len Vogler (who died in August)
I never in my life would have guessed that at some point in time I would be the illustrator of a book written by my son
The book is available for purchase online for $18.99 through SouzaFamilyBooks.com
It was published late last year by Souza Family Books
Follow @SGAndrewLegare on Twitter
There are few people working in landscape photography today that have more influence on the contemporary scene than Marc Adamus
or running his Photo Adventures in the mountainous wilderness of Alaska and western Canada
as we are all locked down right now with our workshops canceled or postponed
Marc and I had a rare opportunity to sit down over video chat and discuss his unique approach to his images and creativity
Something most people don't know about Marc
is his deep love for the landscape and the humility with which he enters these stunning areas
This is probably the only free online resource where he opens up honestly and sincerely about himself and his work
Image by Alister Benn taken on a Trip to Everest in 2015
He talks about having difficulties in school and learning using traditional methods
This has led him to improvise and find his own way of doing things
Little did he know back then that he would inspire so many others around the world to approach image-making with such passion and technical mastery
Alister Benn lives and works on the west coast of Scotland
Usually spending many months a year running workshops for Expressive Photography to Spain
the Arctic and of course the west of Scotland
With his partner Ann Kristin Lindaas they produce weekly videos for their YouTube Channel
I always look upon it with profound admiration and extreme envy
I've been luck y to hang out with him quite a bit and he's a very motivating guy to be around
I went to Marc's webpage to see his body of work
but I like his interpretation of each scene
taste is always personal and open to interpretation
He puts himself in some amazing places with incredible regularity :-)
but what I hope came across in the conversation was his humility
He is a guy who simply loves the landscape and feels small in it
it’s notable that he is one of the people responsible for the style of many landscape photographers
but a lot of people are trying to copy his style
There is a whole generation of shooters out there modeling their images on his
many mothers are enduring the lasting effects
A recent Harvard Health study shows 41-percent of women have turned to heavy drinking to cope since the start of this pandemic
We headed to a Christian-faith recovery center for women that will open in Waukesha County very soon
We all know addiction does not discriminate
yet this is the reality for those seeking help in Waukesha County
“There is not a residential treatment program in Waukesha County
and there hasn’t been since 2008,” said Debra Adamus
Now, there soon will be. Bethany Recovery Center sits on five acres of woods in Oconomowoc
They hope this will serve as a sanctuary for women going through the throes of addiction
Jennifer Schmeichel with Bethany Christian Services of Wisconsin says This includes pregnant mothers
“Allow them to receive medically assisted treatment while they’re pregnant which is a safer way to go vs out there using drugs.”
Their children up to five years old can stay with them
This new treatment center’s parent organization is Bethany Christian Services which is one of the largest evangelical adoption agencies in the country
Adamus says many times it is hard to stay in touch with women who are addicted
“She gets afraid she’s afraid that child protective services will come and take her children she’s experiencing a great deal of shame.”
The treatment program also helps women learn about resources out there to support their families
Or help pregnant mothers explore adoption services
Schmeichel says they will support every woman’s decisions
“Absolutely we're going to support them we need to treat the problem in front of us and we're not going to suggest they have an abortion
but we respect that decision every human being has a decision to make.”
Women do not have to be mothers or pregnant to come to this treatment center
Adamus says there will be family and couple’s counseling to help women manage the pressure
“It’s an eye-opener for women for what their life can become.”
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The management of Adamus Resources Limited (Adamus Australia) has firmly denied reports of invasions and vandalism at its facility in the Western Region
Earlier reports alleged that equipment and infrastructure belonging to Adamus Resources were vandalized during an attack
Sole Director and Secretary of Adamus Resources Ltd
dismissed the reports as “completely false,” describing them as an attempt by the current management of Adamus Ghana to divert attention from the core issue—the ownership of Adamus Resources Limited
Adamus Resources Pty clarified that it has not transferred its 90% shares in Adamus Ghana to Nguvu Mining Limited and urged the public to disregard the misinformation being circulated
“We would ask the discerning public to disregard all such false reportage
We take this opportunity to re-emphasize that at no point has Adamus Australia transferred its 90% shares in Adamus Ghana to Nguvu Mining Limited
and call for a thorough and fair investigation on how the ownership of the shares has changed from Adamus Australia to Nguvu Mining Limited
to be conducted by the relevant authorities.”
Adamus Resources Pty Limited explained that its Interim Management Committee met with some officers of Adamus Ghana
It stressed that the IMC did not go to the mine site with any armed persons
nor was any property destroyed as reported
“In furtherance of the orders of the court
the IMC decided to pay a visit to the mine site on Thursday 12th December 2024 to observe the operations of the mine site
This was after receipt of reports of the dissipation of company machinery and the smuggling of gold by some persons within the company
The IMC is also in receipt of information on Adamus Ghana’s failure to pay its contractors and settle its tax obligations
“This was a peaceful visit by the IMC member to the company
The IMC member and his team met on the site
officers of the Ghana police service who acknowledged the existence of the court orders but still refused the member access to the administration
“The IMC member after hours of waiting was allowed to meet with some officers of Adamus Ghana
the IMC did not come to the mine site with any armed persons
and neither was any property destroyed as falsely reported.”
Click here to read the rejoinder by Adamus Resources Pty Limited
Armed men storm Adamus Mines, cause destruction to properties
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Game Workshop is bringing another assassin into the Horus Heresy mix with the Adamus Assassin
The past few weeks GW and Forge World have been pumping out new assassins for the Horus Heresy
we get another one with the Clade Adamus Assassin
via Warhammer Community
“The Adamus Clade is believed to be the oldest of the formal orders of Assassins
and its operatives are experts in the art of the decapitation strike – proving that old Terran adage about the body dying if you can kill the head
noting their strengths and learning their weaknesses
the Clade Adamus Assassin is fast and absolutely lethal in melee
able to go toe-to-toe with almost any foe – and defeat them with their nemesii blade
The Adamus Assassin is the most “ninja” like assassin we’ve seen for the Horus Heresy
You can see how this version seems a lot like the precursor to many of the assassins we have in 40k
the custom weapons — all the modern assassins take something from this model
From looking at this model I guess we can infer which Assassin Clade was the most successful post-heresy era
Give this assassin an huge rifle or the Culexus headgear and he’s basically one of the modern ones
if you want to check out this new assassin’s rules you can find them in the upcoming Liber Imperium book
What do you think of the Clade Adamus Assassin
Games Workshop Rumor Engines: Where Are They Now - September 2021 Edition
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Angela List
— Putting your child on the bus for the first day of school is always a leap of faith for a parent
on top of the usual worries about youngsters adjusting to new teachers and classmates
Rachel Adamus was feeling those emotions Monday morning as she got 7-year-old Paul ready for his first day of second grade and prepared 5-year-old Neva for the start of kindergarten
With a new school year beginning this week in some states
Adamus struggled to balance her fears with her belief that her children need the socialization and instruction that school provides
death toll from the coronavirus has hit about 155,000 and cases are rising in numerous places
As the bus pulled away from the curb in Adamus’ Dallas
“We have kept them protected for so long,” said Adamus
who said her aunt died from COVID-19 in Alabama and her husband’s great uncle succumbed to the virus in a New Jersey nursing home
“They haven’t been to restaurants
We only go to parks if no one else is there
We don’t take them to the grocery store
And now they’re going to be in the classroom with however many kids for an entire day with a teacher.”
The Adamus children are among tens of thousands of students across the nation who were set to resume in-person school Monday for the first time since March
Mississippi and Tennessee will also be among those navigating the new academic year this week
Many schools that are resuming in-person instruction are also giving parents a stay-at-home virtual option; Adamus
Other schools are planning a hybrid approach
with youngsters alternating between in-person classes and online learning
But an uptick in COVID-19 cases in many states has prompted districts to scrap in-person classes at least for the start of the school year
President Donald Trump and Education Secretary Betsy DeVos have urged schools to reopen
the nation’s top infectious-disease expert
warned Monday: “There may be some areas where the level of virus is so high that it would not be prudent to bring the children back to school.”
“So you can’t make one statement about bringing children back to school in this country
It depends on where you are,” he said
though that is not mandatory for the 30,000 students in the county
Adamus said her son and daughter understand what’s happening at a basic level — that there are germs and they need to stay home
“My daughter’s been saying a lot lately
`I can’t wait for the germs to go away,'” she said
Adamus lives near North Paulding High School
where the principal sent a letter over the weekend announcing a football player tested positive for the virus after attending practice
said it has received reports of 655 positive tests since workouts for football and other sports started on June 8
Emily Thompson’s son started the sixth grade at Newton County Middle/High School in Decatur
said she felt relief watching him get in line to have his temperature taken before entering the building
found it was a “nightmare” trying to keep the boy and their two other elementary school-age children on track with their studies
She said she is not overly worried about her children getting sick at school
“It would be more detrimental not to send them
than for them to hang out and do the virtual learning,” she said
“I think they’re going to get more interaction at school
They just need to be in that setting.”
a student at Greenfield-Central Junior High tested positive on the first day back to class and was isolated in the school clinic
“This really does not change our plans,” School Superintendent Harold Olin said
“We knew that we would have a positive case at some point in the fall
We simply did not think it would happen on Day One.”
Elwood Junior Senior High suspended in-person classes two days into the school year after at least one staffer tested positive
One student who wasn’t starting at North Paulding on Monday was Aliyah Williams
said she is keeping the 14-year-old freshman home because two of her younger sons have cystic fibrosis and she can’t risk their being exposed
Williams said she thinks her daughter will be OK academically with online classes
which up to 30% of the district’s students have enrolled in
But she is worried about Aliyah’s inability to see her friends
That’s a big part of her personality,” Williams said
Aliyah has been participating in color guard with the school band
but Williams said she is now “conflicted” about that too
considering the football player’s positive test
Other Paulding County parents were eager for in-person classes
Jenna Thames drove 8-year-old Brantley to his first day of third grade and 6-year-old Rhett to his first day of first grade
Thames said that no one at her house is high-risk and that as a former teacher
she thinks her children will learn more from teachers than they did from her in the spring
“They’re going to actually listen to their teacher
it was a fight every day,” Thames said
“I absolutely trust our administration and our teachers to do what it takes to keep them safe and keep themselves safe.”
dismayed that the Paulding district refused to mandate masks or push back the start date for in-person classes
there has been little organized opposition
“I desperately want to return to face-to-face teaching
but not until it is safe,” Steven Hanft
Other parents have to balance their job with schooling decisions
Shannon Dunn has to report to her job this week as a cafeteria manager at an elementary school in Baton Rouge
but she has no idea what she will do when her daughter starts kindergarten with online-only instruction
at 12 o’clock you are going to have to start working online with her for school,'” Dunn said
School officials have said they hope to begin in-person classes after Labor Day
But Dunn said that will not ease her mind completely
“If I hear of the spread of COVID at the school
then I’d have to rethink it all over again,” she said
schools remained closed across much of Europe
which is still in its summer vacation season
But schools in Germany’s Mecklenburg-Western Pomerania state became the first in the country to reopen since March
Students were split into groups to help contain any outbreak
and some of the schools imposed mask rules
Copyright © 2025 Ogden Publications of Pennsylvania
Could the stone be the author of the exhibition
let’s try asking it another way: Could the stone be a co-author of the work
What is the role of stone in contemporary art anyway
When did it cease to be a mere material to be worked and become an entity in itself with its own meaning
or perhaps even an artistic partner for conversation or wandering
The exhibition The Beginning of Stone tells the story of stones through the work of contemporary artists
It presents an interdisciplinary theme of ontological
existential and symbolic qualities that can enter our thoughts out of the blue
or conversely through a careful search for flint or precious stones
in the Ellembelle District of the Western Region
Chief Executive Officer (CEO) of Adamus Resources Limited for her exquisite role in championing development in communities in the area
the CEO has worked hard to transform the lives of the youth
by providing them with job opportunities and trained women to acquire skills for their livelihood to be enhanced
They have therefore called on the people of Nzema to disregard any report
These were made known when the youth of Nzema and some opinion leaders
took to the street at Nkroful to demonstrate peacefully to show their solidarity and unflinching support for Ms
They held placards some of which read “Leave Angela List Alone”
is due to Angela List’s exceptional leadership
the company wouldn’t be where it is today without her”
“Angela List is a wonderful example of dignity and servant leadership”
Angela’s consistency shows dedication as a leader who puts the company’ best interest first”
Others are; “the contributions of Angela List have been crucial to the successes and positive trajectory of Adamus” as well as “we appreciate Madam Angela for prioritizing the employment of Nzema Youth in Adamus”
“we believe that a peaceful atmosphere and harmony among stakeholders are critical to sustaining the company”
needs a peaceful environment to sustain the fortunes and future operations of the mine
should be allowed to operate and promote the growth of the company and we will also benefit
He mentioned that about 70 percent of staff at Adamus are Nzema’s
has ensured the development and corporate social responsibility programmes in terms of education
health and the growth of the private sector
the Nkroful SHS has been renovated at the cost of GH¢200,000 and also engaged the agriculture teachers at the school to produce chicken and vegetables
She has constructed a 12 -unit classrooms for the Teleku Bokazo Primary School to improve access and quality education for children in the area
she has ensured the registration of community members onto the National Insurance Scheme (NHIS)
she said has provided two 16-seater aqua privy toilets at Anwia and then constructed Anwia Nursery School Block
She has provided solar lights in about 11 communities including Bokazo
which has contract with Liebeherr has employed only females from the Nzema enclave as the drivers of these trucks and a total of almost 700 out of the over 1000 workforce
he noted contributes to over 60% of the workforce who benefit directly and more than 1,000 indirectly
working and serving the corporate interest of Nzema
is a woman who has the interest of Nzema’s and should be allowed to continue with her good works.”
is a woman who wants to ensure that Ellembelle
She needs a peaceful environment to work and we will benefit more from development than what we see today
Our interest is the survival of Adamus and not the conflicts”
Chairman of the Juniour Staff of Adamus Resources indicated that “Madam
has been taking care of all the workers here
“we will continue to rally behind her for development to continue to thrive in the communities”
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The company cites a court ruling affirming the continuation of its operations
Adamus Resources Pty (Adamus Australia) has categorically denied claims that it has transferred its 90% shares in Adamus Ghana to Nguvu Mining Limited
This follows a statement by the Ministry of Land and Natural Resources dated Thursday 27
which alleged that records at the Minerals Commission show Nguvu Mining Limited holds 90% shares in Adamus Resources Limited
with the government holding the remaining 10%
Adamus Resources has described the Ministry’s claims as “unfortunate” and made in “utter bad faith”
The company maintains that it has not sold or transferred its 90% shares in Adamus Ghana to Nguvu Mining Limited
Adamus Australia is calling for a thorough and fair investigation into the matter to determine how the ownership of the 90% shares allegedly changed hands
The company has also expressed its commitment to pursuing justice through the court process
Click here to read the statement by Adamus
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Professional landscape photographers Ryan Dyar
and Simon Roppel are here to help us understand why certain decisions in editing process are made
Everyone at the table knows about Marc Adamus catching a lot of flak for his art
all of us sometimes get the axe in one form or another
With Simon Roppel just coming back from a shoot at Mount Assiniboine in Canada
we started with the issue of compositing images; superimposing one photo with another in order to create a more pleasing image
Roppel often uses a technique called time stacking
in which he takes one shot at dusk and another later in the evening to get the best of both worlds
He thinks it’s a great thing that digital processing allows us to do
Roppel doesn’t understand the resistance that rose up against Adamus’ imagery
“It’s all art,” Roppel explains in deceitful simplicity
Eventually we are all trying to create something beautiful and emotional
Capture techniques as compositing images or time stacking just don’t trigger the emotional response we are looking to illicit
colourless sky when he captured his work “Slow Motion.” And while he typically doesn’t like to fake light
he does frequently want to improve upon it
This example is different with the decision to give the sky some colour where in actuality there was none
Gómez agrees and adds that art is supposed to free us instead of confine us to the bounds of collective appreciation
He does struggle with finding the words to describe this new form of photography
Dyar definitely leans more towards the creative side of this argument
straight-out-of-camera purist side isn’t his way of creating art
the stars in his work “Night Watch” were photographed about an hour after the exposure he used for the foreground areas
He put them together in post-processing using a Lighter Color blend mode
you can prevent having to dial in a higher ISO that will lower the quality of that foreground
people often ask if those goats were real or a composite
Dyar wouldn’t feel comfortable with making such a composite and prefers keeping such elements real and natural
Ted Gore and I talked in a previous episode of this series about the use of bracketing exposures to capture a wider dynamic range
While camera’s today are doing such a great job at capturing high contrast scenes in single exposure
Charles Wyckoff made images of nuclear explosions that got published in all sorts of magazines like Time and Life
Ansel Adams was the landscape photographer’s king of photo manipulation
and he is revered as one of the greatest photographers who ever lived
His “zone system” is basically dark room (film) HDR
in which he sought to show detail in shadows and highlights as he saw fit
This is a photo by Charles Wyckoff of the fireball a few microseconds after detonation
The fireball measured 3 1/2 miles in diameter
We all use all sorts and kinds of photography ‘life-hacks’ to make that stand-out work of art
We either manipulate light before it hits the sensor
or stretch the histogram in post to make it more pleasing to the eye
Using sheets of glass or resin in front of the lens too is a form of manipulation in order to let the camera record more data than it initially can with a single
Gómez doesn’t put graduated neutral density filters in front of his lens anymore
If the dynamic range is too wide to show both details in shadows and highlights
he instead shoots two images at different exposures and blends them together in post-processing
Gómez applied a simple blending technique like this in his seascape “Easter Island”
“It's a wonderful day to be yours” by Felipe Gómez
Dyar uses the same technique in scenes of extreme contrasting light
He stacks the images as layers in Photoshop
throws a mask on the top one and paints in the brighter or darker exposure by hand
Many consumer grade cameras and smartphones alike
By rapidly firing a couple of shots using an electronic shutter at different exposures
the camera takes mere seconds to blend them together
It’s interesting to note that this technology starts to become mainstream
Do the professionals and their experimentation with capture and processing techniques have any causal connection with this technology becoming available for the masses
I think that as the professionals start to experiment more
demand more from their equipment and do more in less time
it is this technology that then starts to percolate down into the consumer market
features will be put into professional gear as well
In the years to come, cameras will be enabling photographers to do even more after we press the shutter button. We will be able to make decisions about selective depth-of-field and perspective blending, as the multi-lensed camera of tomorrow promises to record much more information than can be shown on any print or any screen at a certain point in time
Felipe Gómez will be pleased with advancements such as light field technology
He points out that you have to be very attentive to capture the DOF that you're after in a landscape image
In a picture where there is a very close object like a flower or rock
it's crucial to use the stacking technique to get everything in focus
And the diffractive effects of f/22 are actually detrimental to image sharpness
It would be great when the lens’s sweet spot can be used over and over again for the most sharpness and least amount of optical aberrations
Capturing the same composition with multiple lenses at once has another benefit
Perspective blending is a great way to deal with the problem ultra wide lenses are creating
He used perspective blending a couple times before to avoid pincushion distortion
in which you need a big foreground and want the mountains to stay as big as they should
“That really just depends on the scene and what I'm hoping to achieve.” Perspective blends can be great
but as with blending for added dynamic range
forcing a technique on a scene that doesn’t really need it
Technology should be in service of a photographer’s artistic choices; not the other way around
With technology coming to the aid of the photographer to capture more data to work with
the pros will still be doing things manually for a long time
End even when professional grade cameras with such features start hitting the shelves
the pros will still be experimenting with any advancements that are at our future disposal
Don’t be afraid that computers will be in charge of the creative process in the future
Tomorrow’s technology will just capture more data and creative decisions will still left to the artist
Felipe Gómez let his camera capture four different exposures to capture the dynamic range he encountered at Cerro Torre in Patagonia
But he still decided which part of those 4 exposures made it into his work
Gómez agrees with Ted Gore’s previous comment about the hardship of photography in this place
he knows Patagonia to be a very dynamic and hard place to take pictures
so you don't have all the time of the world
You have to be familiar with your equipment and quick on your feet under these rapidly changing
even transient conditions that last mere seconds
or photographs we use to create art; a good sense of timing is still an important aspect of communicating reality through two dimensional imagery
Roppel’s “The Perfect Moment” is one of his favourites
because of such transient conditions Gómez mentioned
He composed that shot as his girlfriend convinced him to stay and wait while he was ready to pack up and leave the scene
hail and rain fell from the sky with a great sunrise from behind them
He says he never saw a show like that before and he’s happy that he captured it all on camera
That brings us to the true value of the pursuit of photography
Are you selling images based on what others think of your work
or do you first and foremost shoot for yourself
And how big a part do you think that processing is of photography
I truly believe that the near future of post-processing holds more discussion
as more and more options will open up after we press the button
It’s not the end of the debate for what is or isn’t photography
but we can start to agree upon what is or isn’t art
I think we need to get off our high horse of judgment and be more open to though-provoking imagery altogether
I see good photographers around the globe getting discouraged because of what others think and that’s a shame
Dyar agrees that it's best for each individual photographer to find his or her own moral compass and boundaries
and stop trying to force those boundaries on anyone else; whether you think composites are wrong or right
I also think that artists would do their selves a lot of good by not taking criticism too personal
Even if a critique is aimed at the photographer and not the photograph
A professional and welcoming approach to someone’s opinion works wonders if you reflect that criticism back onto your work of art
we are all trying to get better at what we do
In the next and final episode of this series about reality versus beauty
we’re wrapping things up with two more gifted photographers who show us an otherworldly
All images and paraphrases used with permission of the respective photographers, Ryan Dyar, Simon Roppel and Felipe Gómez
While his dramatic landscape photography has gained international acclaim
his pursuit of the light is primarily a means to get to know himself
Daniel teaches introspective landscape photography around the world through running tours and workshops
Even if all of these were computer graphics I'd still think these guy's 'works' are amazing art
It's the finished result not the canvas that matters surely
This depends entirely on what your goal is as a photographer
and photography merely happens to be a medium that you choose to "gather your inspiration" from
know that you are in fact departing from photography itself
then you're on the right path for your own personal vision
and demand to be called a photographer and nothing else
in my opinion you should take a long hard look at where you're drawing the line in photomanipulation
and be honest and open about how you create your images
and never get angry if people call you out on a "fake" (composite) or are slightly less impressed if/when you reveal that an image is heavily photoshopped
Agreed 100% Personally I only make the most of what I've taken and I draw the line at replacing skies etc
If I feel the final image would benefit it
Where my line gets blurry though is with some of the portraits I've been experimenting with
For example a shot with a model on a beach (camera on tripod) then a long exposed image without the model and the two images blended together
Is this (by your argument) still photography
The image would be impossible to achieve in one shot -unless my model can stand perfectly still for say 15 minutes
I'm not sure but I don't mind explaining to anyone who asks how I got the result but I still consider myself a photographer not a composite artist
perhaps I'm the only one here having issues with the reporting
Not an issue with the idea of the articles
not at all as it is an interesting conversation
Here's where this is coming from...."But in another photo; “Goat Crossing”
Dyar wouldn’t feel comfortable with making such a composite and prefers keeping such elements real and natural." Sorry
that goat is a composite...not even a question
No way the water blur happens AND that goat is frozen in that position
So again there is a level of misrepresentation taking place that doesn't express the truth
no way that these "elements (are) real and natural." Are we lemmings
Maybe it is a "real and natural" stuffed goat
Here is why I hesitate to call people out these days
on pretty much all but the most blatantly obvious photoshop hack-jobs: Based on my own personal experience photographing poeple near running water
(though not wild goats) ...I'd wager that it's entirely possible for that shutter speed to be the same for both the animal and the running water
The water's blur is not really that smooth
if you look closely you can still see plenty of splash lines
indicating to me that the shot might have only been a 1/2 second exposure or something
Most animals are even better at holding perfectly still than a human being
(they have four legs) so I'd bet that this goat
if pausing for a moment of curiosity about the photographer or the camera
(if it was captured by a remote camera) might have very well held perfectly sill for 1/2 sec or even 1"..
I'd bet that the more likely scenario is this: The photographer used a camera with extreme dynamic range
such that they could shoot a neutral exposure at 1/4 or 1/8 sec for the animals
and then blend in the brighter 1" or 1/2 sec exposure for the water
then of course the 1/25 or 1/50 exposure for the sky
(Now both Canon and Nikon can do 3EV increments for bracketing
so this shot could have literally happened as we see it
and be captured at the same exact moment as a bracketed exposure
I'm not personally opposed to merging different exposures to capture better water blur without sacrificing image quality elsewhere
they're created by shortcomings of a particular lens+sensor combo
And obviously the whole situation is open to interpretation by each individual artist
I would change the title to "Beautiful vs Commercial"
It seems that today who doesn't create lights or/and moves objects within the frame using PS is a purist
Of course it's a good advertisement to sell your works
but I would consider the fact that photography goes beyond 500px and Facebook
Try to have a look at these links (below) and please tell me if you would define these pictures just "Real"
There are lots of creativity and strong messages
while here above in your article I can see the need to spectacularize everything
but I would suggest you to use the word "Art" with care and not only to justify your ideas
https://www.gdtfoto.de/seiten/gdt-european-wildlife-photographer-of-the-...
http://www.nhm.ac.uk/visit/wpy/gallery/2015/adult.html
"Photographs are like gems: the real and the synthetic are often physically indistinguishable
but there is no question as to the ultimate value
A photograph that depicts a moment of real life
whether that of a human activity or of the natural world
is of a higher order than the most perfect replication created by or for the camera with luck removed from the formula."
there will always be purists on opposite sides of the spectrum
Ansel Adams is not a purist by anyone elses standard
He probably did the most darkroom manipulation during his time and yet..
If he did his art today I'm quite sure he will be maximizing whatever tool or technique that is available to perfect his photograph
I'm sure he would still be called a photographer
After all we don't hire graphic composite artists to cover our wedding no matter how much digital manipulation she does
Mikolai Adamus has shared with us his proposal for a “New Aquarium” to activate the Southern Pier in Gdynia
Using the golden ratio and the Fibonacci sequence to guide the design
the rectangular structure burrows into the pier
becoming secondary to the surrounding landscape
the aquarium is designed to transparent and “a place where architecture is subordinated to function
devoid of unnecessary detail.” More details
From the designer: The main emphasis of the design is not so much the creation of a building, but an attempt to generate a place. The South Pier is an area of unique character. Its farthest point is definitely the most important part. The local land use plan assumes that the end of the pier should remain without buildings. Nevertheless, the question arises of how to make people more keen to pass time at this location.
© Mikolai AdamusA Building for the Square
The proposed construction consists of four main interdependent parts: the elevation, the part above the square, the roof and the part below the square. It is only the juxtaposition of these elements that enables the full potential of this location to be realized.
© Mikolai AdamusThe elevation: The pier end will be elevated by 2 meters above its current height. The square itself will only be raised to the height required so as to be able to see the view at the end of the South Pier and so as to provide a destination towards which to walk.
The part above the square: The part above the elevation forms a square protected from the weather. At the same time, it is possible to see from the section above the square what is going on below.
© Mikolai AdamusThe roof: This constitutes an additional viewing terrace. It is another type of raised square, this time uncovered, which enables an extensive view to be surveyed, for example during the regattas that frequently take place in Gdynia.
The part below the square: Elevating the square provides the chance to create features in this place, which could attract new users to the end of the pier and also interest users, who have already reached it.
Achievement of the greatest possible transparency was the most goal. The idea was for the user inside to feel sheltered from the weather in the square. However, the building was to present the smallest possible barrier to an observer outside looking at the views. At night, the glass elevations of the building would act as a lamp illuminating the surroundings.
Apart from transparency, flexibility constituted a second aspect for the upper part of the building. During normal use, the building should be as transparent as possible, but it should have the facilities required for the organization of various types of special events, such as lectures, exhibitions or banquets.
© Mikolai AdamusFibonacci and the Golden Ratio
I attempted to use the golden ratio and the Fibonacci sequence in order to create compositional lines to define the fundamental geometrical expression of my building
I used these proportions to create the axis and elevation of the building
This seemed to be even more appropriate given the links between the function of the building and nature
the fruit of the pineapple shows eight such lines running in one direction and five or thirteen lines in the opposite direction
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Adamus Resources (Pty) Limited (Adamus Australia) has denied the Ministry of Lands and Natural Resources' claims regarding the ongoing dispute over the ownership of Adamus Resources Limited (Adamus Ghana)
The company has debunked claims that there was no constituted Interim Management Committee (IMC) and that the pendency of certain applications was hindering the formation of the IMC
in response to a press release issued by the Ministry of Lands and Natural Resources regarding the ongoing dispute over the ownership of Adamus Resources Limited (Adamus Ghana)
stated that the Ministry's press release was "very unfortunate and made in utter bad faith."
Adamus Australia explained that it had been seeking to remove Angela List as a director of Adamus Ghana since December 2021
but the Ministry had failed to support its efforts despite being informed of the irregular appointments made by Angela List
The company also alleged that the Ministry had sided with Nguvu Mining Limited
and had ignored court orders and the rule of law in the matter
Adamus Australia emphasised that it had never sold or transferred its 90 per cent shares in Adamus Ghana to Nguvu Mining Limited and called for a thorough and fair investigation into the matter
The dispute between Adamus Australia and Nguvu Mining Limited has been ongoing since 2021
with both companies seeking control over Adamus Ghana
The matter is currently before the courts in Ghana and Australia
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Source: peacefmonline.com
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According to the IMC
the the advice offered to Angela List is an aberration of the court ruling