As part of North Texas Overdose Awareness Day in Denton photos lined the Courthouse on the Square lawn Saturday in remembrance of locals who have died to drug overdoses asked if any among them had lost someone close to them due to an overdose Jary lost her own brother to an overdose in 1987 His death was followed by two of her students’ overdose deaths during her 10 years of teaching at Weatherford College “I feel like today is a tribute to their memory .. our love for them continues,” Jary told the crowd assembled for North Texas Overdose Awareness Day North Texas Overdose Awareness Day in Denton on Saturday An origami butterfly booth during the North Texas Overdose Awareness Day event on the Denton Square Resource booths set up on the Courthouse on the Square lawn on Saturday for North Texas Overdose Awareness Day Local nonprofit Reacting to Opioid Overdose (R.O.O.) organized the event on Saturday in Denton and provided resources A band from the First United Methodist Church Denton performed at the North Texas Overdose Awareness Day in Denton Saturday A wall of photos shows people who have died to drug overdoses which was more than 100,000 nationally in 2022 Photos lined the Courthouse on the Square lawn Saturday in remembrance of those lost to drug overdoses Denton Mayor Gerard Hudpseth presented Sharon Roland Denton County Friends of the Family set up to provide information and support during North Texas Overdose Awareness Day at the Courthouse on the Square lawn Saturday who is the chair of the Texas Association of Addiction Professionals Fort Worth chapter was one of many individuals who spoke during Saturday’s event First held in 2018, North Texas Overdose Awareness Day aims to remember those who lost their lives to overdoses and provide valuable information on overdose prevention and awareness to North Texans Ovidiu Berca told the crowd about turning himself in at Denton County Jail in May 2023 He recalled being drug tested on bond supervision and feeling he just couldn’t get it together Berca was fed up with the way his life had been going and decided to reevaluate; he knew the path he was going down could lead to his death I had my ninth overdose,” Berca told the crowd and I am extremely grateful to the drug court team all the other members of drug court that have helped me change my life and see things differently It is an existence of despair and hopelessness There is hope for every addict out there.” The Denton County Drug Treatment Court operates in the 211th and 462nd district courts provides intensive supervision and treatment to high-risk felony offenders wanting to break the cycle of drug addiction “This is a collaborative team effort where judges treatment providers and corrections/probation work together to figure out what is the best way that we can help our participants,” Kevin Edwards program director of the Denton County Drug Treatment Court “It’s a 24-month program that is high structure high treatment and high levels of accountability and we work as an alternative to incarceration We focus on felony level drug-related offenses to provide people that potentially are looking at long-term prison sentences an alternative to actually get help for their substance use disorder.” JUAN BETANCOURT can be reached at juan.betancourt@dentonrc.com Solutions of North Texas is now offering Denton’s first no-cost detox program Email notifications are only sent once a day Your browser is out of date and potentially vulnerable to security risks.We recommend switching to one of the following browsers: Account processing issue - the email address may already exist Your essential companion for starting the day in Denton Delivered fresh to your inbox every morning Wake Up gives you a curated snapshot of local news for the day as well as the day’s e-edition and trending stories you may have missed Sign up for the Denton Record-Chronicle's absolutely free weekly newsletter highlighting winners and finalists from the 2024 Best of Denton awards Your weekly guide to surviving college and thriving in Denton local news and more exclusive content in your inbox every Tuesday afternoon There's always something going on in Denton Check out what's on the local events calendar and plan a fun weekend with friends Get a roundup of the 10+ puzzles and games available from the Denton Record-Chronicle for free Sudoku and other brain-busters are new every day the latest in puzzles and word games with a Wordle vibe From minor traffic accidents to neighborhood watch updates stay informed on public safety with the week’s top crime stories in your inbox every Wednesday morning Don’t miss out on breaking news in Denton from weather and traffic to big events and important headlines Be the first to know the latest on new stores restaurants and other businesses in Denton County so you can live better here Get the scoop on all the thrilling victories nail-biting games and standout performances — straight from the sidelines of Denton-area high schools we bring you the highlights and updates from our hometown college teams Prepare for the polls and stay informed on the candidates issues and deadlines for Denton County’s key races Save money and find what you need with promotions from local businesses and special DRC offers Invalid password or account does not exist Submitting this form below will send a message to your email with a link to change your password An email message containing instructions on how to reset your password has been sent to the email address listed on your account Photos.css-3hcdeq{margin:0;font-size:1.2rem;-webkit-text-decoration:none;text-decoration:none;font-family:Proxima Nova,Proxima Nova Fallback Helvetica,Proxima Nova Fallback Arial;font-weight:400;font-style:normal;letter-spacing:0rem;line-height:1.44rem;color:var(--br--palette-foreground__tertiary-mainChannel);}Doric SamMay 13 1) 0ms;transition:background-color 150ms cubic-bezier(0.4 1) 0ms;transition:fill 120ms cubic-bezier(0.4 1) 0ms;font-size:inherit;}.css-v4v4rs{-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:1em;height:1em;display:inline-block;fill:currentColor;-webkit-flex-shrink:0;-ms-flex-negative:0;flex-shrink:0;-webkit-transition:fill 120ms cubic-bezier(0.4 1) 0ms;font-size:inherit;}@media (min-width:0px){.css-v4v4rs{display:block;}}@media (min-width:1100px){.css-v4v4rs{display:none;}}.css-mps3fk{-webkit-user-select:none;-moz-user-select:none;-ms-user-select:none;user-select:none;width:1em;height:1em;display:inline-block;fill:currentColor;-webkit-flex-shrink:0;-ms-flex-negative:0;flex-shrink:0;-webkit-transition:fill 120ms cubic-bezier(0.4 The team revealed the new threads with a pair of social media posts including a video narrated by hip-hop star Kid Cudi The team described the uniform as "a celebration of the team's connection to Northeast Ohio from Berca sandstone to Cleveland teams from the early '90s." Jason Wiedemann, Guardians vice president of Brand, told Gharib that the team wanted the uniforms to resonate with longtime fans of the franchise while also creating a bolder version of their current uniforms. "We wanted to take this as an opportunity to really [show] what makes Cleveland special, sort of not just from a visual standpoint, but also thematically or what are those sort of characteristics that we think are special about Cleveland and Clevelanders," Wiedemann said. Gharib noted that the players' reactions to the new uniforms were "positive." They had some involvement in the design process but didn't see the final product until after spring training. The Guardians snapped a three-game skid by defeating the Chicago White Sox 7-0 on Sunday. Cleveland improved to 25-16 and now leads Minnesota by a half-game for first place in the AL Central. The Guardians will begin a three-game set against the defending World Series champion Texas Rangers on Monday. Using self-report questionnaires, we evaluate the scientific, professional, and personal growth of ESRs over the duration of the ITN and investigate whether this can be linked to network activities. Our quantitative analysis approach reveals substantial improvements in scientific, professional, and social skills among young researchers facilitated by the engagement in this interdisciplinary network. We provide case studies underlining the advantages of collaborative environments, featuring innovative scientific exchange within TranSYS. While challenging, ITNs foster positive growth in young researchers, yet exhibit weaknesses such as balancing stakeholder interests and partner commitment. We believe this study may benefit a variety of stakeholders, from prospective ITN creators to industry partners, to design better sustainable training networks going forward. Volume 11 - 2024 | https://doi.org/10.3389/fmed.2024.1348148 Introduction: In the evolving healthcare landscape precision medicine's rise necessitates adaptable doctoral training The European Union has recognized this and promotes the development of international training-focused programmes called Innovative Training Networks (ITNs) an ITN focused on educating the next generation of precision medicine researchers In an ambition to go beyond describing the consortium goals our article explores two key aspects of ITNs: the training and collaboration and personal growth of ESRs over the duration of the ITN and investigate whether this can be linked to network activities Results: Our quantitative analysis approach reveals substantial improvements in scientific and social skills among young researchers facilitated by the engagement in this interdisciplinary network We provide case studies underlining the advantages of collaborative environments featuring innovative scientific exchange within TranSYS ITNs foster positive growth in young researchers yet exhibit weaknesses such as balancing stakeholder interests and partner commitment We believe this study may benefit a variety of stakeholders from prospective ITN creators to industry partners to design better sustainable training networks going forward The ambition is to use individuals' phenotypes and genotypes (e.g. lifestyle data) to tailor the right disease prevention or therapeutic strategies for the right person at the right time To approach the challenges associated with this paradigm-shift in disease prevention and healthcare the involvement and collaboration of key stakeholders understanding the molecular-level causality of pathogenesis becomes crucial Highly interdisciplinary skill sets are now needed to exploit big datasets and scientific advances that can drive improvements in the prevention and development of tailor-made interventions for individuals or groups of individuals The collaborative nature of precision medicine which integrates expertise from diverse fields such as genomics Transparent communication across disciplines guarantees a shared understanding of goals fostering a cohesive and responsible research environment Ethical considerations extend to acknowledging and addressing biases and safeguarding against the misuse of data a commitment to interdisciplinarity promotes a holistic approach to healthcare that reflects the complex interplay of genetic precision medicine can fulfill its promise of providing tailored and ethically sound healthcare solutions for individuals and communities • Collaborations and consortia building The consortium at the core of TranSYS consists of a combination of expertise in various fields including Systems Medicine completed by industry partners at the forefront of innovative future healthcare All ESR research projects were complemented by training covering technical (genomics and ethics) and key soft skills relevant to high-level research career paths as future leaders for the Precision Medicine revolution The ESR projects in TranSYS aim to address barriers related to translational systemics (e.g. limited access to validated data and lack of standards for data storage and curation along with data privacy concerns) and deliver key innovations to enhance disease detection This paper provides an in-depth exploration of the TranSYS ITN In an ambition to go beyond simply describing goals of the consortium we aim on giving a detailed insight into two key features of ITNs: the ESR training and collaboration Using self-reported metrics we evaluate the scientific we measure the scientific output of the consortium and highlight individual projects that could only be facilitated by the collaborative nature of an ITN we provide an ESR-perspective on open challenges within ITNs and suggest possible solutions to further improve the experience for early career researchers joining a MSCA-ITN (A) Circos diagram displaying the number (panel) and the scientific output (dots) of each TranSYS ESR (C) Combined educational background or formal training of ESRs ESR color coding is consistent throughout the manuscript All ESR individual research projects were complemented by training covering technical (genomics and ethics) and key soft skills essential for taking a leading position in the Precision Medicine of the future With the goal of gaining a more quantitative impression on the achievements of TranSYS in terms of scientific innovation and impact of ESR training This survey included the questions regarding formal education as well as ratings of official TranSYS events assessing their perceived impact on the development respective skills To assess the development of ESRs throughout the period of TranSYS, we compared the self-reported skill ratings of a set of diverse categories from the start (1st year) to the end of the ITN period (3rd year) (Figure 2). A more detailed analysis of each category can be found in Supplementary Figure 1 It is evident that while ESRs strengthened their skills overall especially their competences in communication (adjusted p-value < 0.05) and research (adjusted p-value < 0.01) significantly improved Communication skills include public speaking while research skills encompass areas such as knowledge of the field with individuals reporting perceived indifference or even worsening of skills we find a lack of growth in the area of Work-Life-Balance revolving around topics such as quality of life ESRs also felt like they did not grow a lot in their professionalism referring to their competence in upholding deadlines Improvement of ESRs throughout the period of TranSYS in six different major skill categories Data was collected using a self-assessment survey upon joining TranSYS (1st year) and prior to rotating off (3rd year) (see Section 5) the lines connecting dots represent the relative change in skill rating Boxplots indicate the summary of all ESRs in respective category and timepoint P-values were derived using a Wilcoxon signed-rank test and multiple testing corrected using Bonferroni correction A value <0.05 can be considered significant The data is clear that while secondments are invaluable in improving research skills and an interdisciplinary mindset taking a toll on ESRs by adding stress due to e.g. Impact of TranSYS bootcamps (A) and secondments (B) on ESR growth The x-axis shows ESRs' perceived impact of TranSYS events on the evolution of skills Skill improvements (y-axis) were derived by calculating the difference in subjective skill ratings of the 3rd and 1st year within TranSYS Individuals in the upper right quadrant (green) show a positive association between event rating and skill improvement Individuals in the lower left quadrant (red) display dissatisfaction with TranSYS events paired with a lack of growth in respective skill Although the global market offer promising job opportunities and sustainable career paths there is a significant demand for skilled researchers who can bridge the interdisciplinary gap between life- and data/computational sciences in the industry the consortium at the core of TranSYS consisted of a combination of expertise in various fields like Systems Medicine An eagle-eye view of the structure of TranSYS can be found in Figure 4 Projects were outlined and designed by beneficiaries according to their research areas and capabilities in order to achieve the following three main goals through interdisciplinary collaborations: The outer circle represents the three key TranSYS objectives: (A) Narrowing the gap between preclinical performance and treatment benefit (B) Developing integrative strategies and corresponding integrated workflows (C) Improving understanding of patient heterogeneity and developing economically viable patient stratification strategies The inner Venn Diagram illustrates the three work packages of TranSYS and the beneficiaries contributing to each of them: WP1 (blue) Preclinical Science and Molecular Medicine (ESR6) dissected the cellular heterogeneity of Parkinson's disease related iPS cells during aging by multiomics to identify disease modifiers (manuscript in preparation) (ESR7) generated a full-characterized (at the histology and epigenetic level) biobank of PDO from bladder tumor samples and use them to study the underlying mechanisms driving resistance to Erdafitinib (manuscript in preparation) Lalli (ESR10) explored the significance of interoperability in model and data integration spanning multi-omics and multi-modal datasets and the transformation of raw data into reusable structures (ESR11) identified aging biomarkers using network-specific MRI analysis (manuscript in preparation) While the scientific ideas at the basis of TranSYS are formulated as these three main goals, they are executed in the form of three work packages, namely Preclinical Science and Molecular Medicine (WP1), Systems Analytics (WP2), and Targeted Therapeutics (WP3). For more detailed information on the strategies formulated within each work package can be found in the Supplementary Note 1 Graphical representation on how ESRs collaborated in successful TranSYS projects (A) Capturing the dynamics of microbial interactions through individual-specific networks; (B) A worldwide spectrum of clinically relevant SNPs associated with drug toxicity: Genetic structure and risk characterization using population sequencing data to unravel geographical patterns and spatial trends in prescribed medications; (C) Deconfounding variational autoencoders for multi-omics data Behnam Yousefi (ESR8), Federico Melograna (ESR1) (16, 17) Federico Melograna (ESR1); manuscript submitted The rapidly progressing field of personalized pharmacogenomics presents a significant potential to transform global approaches to patient drug treatments Under the scientific guidance of a lead researcher (ESR14) and with collaborative efforts from two fellow researchers (ESR1 and ESR15) and analyze genetic variations associated with drug-induced toxicity This initiative laid the foundation for the investigation of the prevalence of these risk-associated genetic alleles on a global scale offering potential guidelines tailored to specific populations which could be valuable for regulatory agencies This collaborative endeavor serves as a compelling example of how the combined expertise of researchers with backgrounds in biology and computational sciences can culminate in a project of substantial significance for both national and international stakeholders While the biological objectives were formulated by ESR14 the comprehensive analysis of genomic variants was made possible through the data mining proficiency of ESR15 the statistical and programming acumen contributed by ESR1 enhanced the project's communication by generating clear and information-rich visual representations of the findings Zuqi Li (ESR2), Sonja Katz (ESR15) (28) The advent of high-throughput sequencing and the analysis of different types of “omics” data has shifted paradigms in biology and medicine Today the field has developed toward multi-omics approaches which follows the idea of using ever more data from different sources aiming to be rewarded with a holistic picture of e.g. is not trivial and biological meaningful analysis is hindered by another problem well known in epidemiology: confounding Currently available data integration frameworks are able to either accommodate multiple data types (from different domains) or correct for biological confounders ESR2 and ESR15 aim to address this shortcoming by merging these two By combining their expertise in confounder adjustment and clustering (ESR2) and knowledge on developing deep learning models (ESR15) the two ESRs were able to implement a variety of deconfounding deep learning frameworks This collaboration shows the potential held in matching ESRs strong computational backgrounds and complementary research interests; advanced in-silico projects yielding tools that may benefit the scientific community beyond the boundaries of TranSYS can be realized To tackle these intricate systems effectively where researchers from diverse disciplines collaborate and pool their expertise MSCA Training Networks have established themselves as a valuable part of the Horizon Europe Framework that aims at developing a skilled workforce capable of driving innovation especially in interdisciplinary fields The TranSYS ITN was established under the previous Horizon 2020 programme offers young researchers the opportunity to gain multilayered training and develop novel techniques and tools revolving around personalized medicine To give a more in-depth view on an ITNs most important asset—the researchers—we evaluated how the opportunities within TranSYS impacted the personal development of its 15 ESR Across the 4 year ITN duration each ESR delivered a core 36 month individual research project and honed their skills in a range of different categories showing a positive learning trend in 5 out of 6 assessed categories we found that not all skill improvements could be attributed to direct ITN training activities such as management and leadership skills or professionalism including skills such as networking or maintaining positive work relationships rather evolve naturally in the course of doing a PhD project that is at the core of the ITN the category “Work-Life-Balance” entailing ratings on maintaining a healthy time management keeping personal motivation or physical and emotional wellbeing showed no improvement and could even be negatively associated with the mobility required within an ITN The implications that can be learned from this finding are further discussed in the Open Challenges within an ITN section of the Discussion Although the statistical power of our analysis is limited due to the small number of ESRs we found that the key training points within an ITN–scientific excellence and advanced communication skill in an increasingly interconnected world—are well reflected in the skill improvement for ESRs The recent evaluation study of the European framework programmes report a remarkably high quantity and quality of research originating from MSCA actions, and measure an expansion of the professional network due to collaborations within consortia (35) The scientific achievements of TranSYS reflect that general finding well—at the time of writing this manuscript a total of 17 different datasets or computational tools have been generated the combined number of publications anticipated at the conclusion of the PhD for all ESRs is expected to surpass 50 with the majority of these manuscripts currently in various stages of preparation The high number of collaborations outside of the planned secondments paint a picture of extensive collaboration and networking within TranSYS Our selection of collaboration success stories clearly illustrate what collaboration within TranSYS looked like how it was facilitated through the skills of individuals and which scientific outcomes were delivered We believe these showcases underline the spirit and opportunities within ITNs as none of these (and other) projects would have been feasible for individual students but were facilitated—or even positively reinforced—within TranSYS EU Framework Programmes, including Horizon 2020, promote several concepts to define societal impact, amongst them the (i) better contribution of research to tackling societal challenges and the (ii) better societal acceptance of science and innovative solutions (4, 35) We argue that TranSYS ESRs have significantly contributed to both points with their focus on tools advancing personalized medicine with the intention of improved patient wellbeing TranSYS featured ESRs solely dedicated to aspects including responsible data storing and model sharing through federated learning and blockchain technology (ESR10) or ethical questions and stakeholders' perspectives on the clinical use of genomic data in clinics (ESR4) With a mindsets toward open and data-driven research and development all manuscripts by ESRs were published open access and the underlying data or code is available publicly or upon request ESRs actively participated in a number of outreach and science communication activities ITN outreach activities largely remained on a local and individual level due to the costs and need for having an established name associated with some activities To broaden the societal impact of MSCA actions and help bring ITNs out of academia and into society we feel the need for dedicating parts of the budget toward funding a joint ITN outreach activity This could be of larger-scale and marketed more effectively than the individual small outreach activities currently organized In the spirit of adding to the continuous development of the MSCA Doctoral Training Networks we provide a critical view on current bottlenecks in ITNs and give suggestions on how these can be best addressed to further improve the experience of future ESRs they must be identified early in the project planning phase and all stakeholders have to actively communicate their interests to achieve a set of focused and shared ITN objectives to facilitate the academic requirements of ESRs doctoral schools enrolling ESRs should acknowledge ITN training with ECTS industry partners should be given the chance for direct input into the design of the research programme and a stronger partnership with less potential for conflicts of interest or how to negotiate difficult topics with supervisors To alleviate some of the stress associated with a secondment a stronger sense of responsibility or even the formal commitment from hosting institutions to assist ESR is needed in the period leading up to their visit This is already built into Doctoral Networks planning but based on the experience of ESRs a more proactive approach needs to be encouraged from the project kick-off A local representative responsible for offering translating skills or aiding in identifying adequate housing may prove invaluable for visiting ESRs The personal perception of TranSYS being very successful in terms of collaboration and shared knowledge aligns well with the numbers identified in the course of this study we argue that the degree of connectivity within TranSYS could have been promoted even more; while ESRs were highly connected through secondments the willingness to collaborate lacked amongst some PIs The COVID-19 pandemic enforced restriction on traveling and in-person events and while summer schools were mandatory for ESRs often resulting in few of them joining events This led to a number of initial project ideas not getting pursued due to the lack of engagement by supervisors or changes in the supervisory team leading to conflicts between initial project directions and changing supervisor interests Collaborations also rarely extended beyond ESRs or PIs to the lab members of beneficiaries; this could be compounded by the individual nature of the PhD projects We can conclude that while a demanding programme the opportunities provided within ITNs are well worth the effort and commitment required to succeed in the dynamic modern research landscape Giving attention to some of the points outlined in this section can lead to the design and implementation of better Doctoral Networks in the future The weaknesses identified can be mitigated without compromising the strengths of MSCA doctoral training programmes ultimately making ITNs an even more attractive choice for aspiring future leaders Despite the majority of projects coming to a conclusion in 2023 Currently most ESRs are in the process of working toward their PhD degrees and looking toward starting new positions in academia and industry all over Europe the multidisciplinary network they built throughout the period of the ITN will not disappear—especially for ESRs seeking to stay in research The connections and working relationships are certain to contribute toward a successful career start in academia In the course of the last official consortium meeting ESRs agreed to the organization of informal yearly reunions to maintain contact in a scientific We hope that this way the connections we built through TranSYS will not only stay strong Precision Medicine has undeniably become a cornerstone of our forthcoming healthcare landscape MSCA training actions have firmly established themselves within the Horizon Europe Framework as the driving force of the new generation of highly qualified scientists the TranSYS ITN has showcased substantial enhancements in the expertise of its ESRs spanning research insight and communication proficiencies The inherent interdisciplinary nature of an ITN necessitates effective communication among peers from diverse scientific backgrounds This environment also exposes ESRs to a continuous influx of novel knowledge thereby fostering the refinement of research-related skills the ITN has yielded substantial collaborative opportunities that extend beyond planned secondments It is crucial to underscore the social impact achieved through outreach and training initiatives as these actions effectively bridge the gap between ITNs and society at large Even though some challenges still remain to be overcome the excellent outcomes derived from this ITN experience across several dimensions and reflected in this work are progressively laying the foundation for robust networks capable of conducting exceptional basic and translational research for the future In an attempt to relate the impact of TranSYS activities (summer schools we asked ESRs to rate the perceived impact of each activity on their development The ordinal scale used for this purpose ranged from 1 (negative impact) to 10 (highly beneficial) Overview of major and minor skill categories assessed For statistical analysis of data collected using the self-assessment survey we aggregated the minor categories to obtain one skill rating per major category for each ESR P-values for the comparison of 1st and 3rd year ratings were subsequently derived using a Wilcoxon signed-rank test and multiple testing corrected using Bonferroni correction To investigate whether TranSYS events show an effect on the skill improvement of ESRs a linear regression for each category was conducted All analyses were carried out using R (version 4.3.1) and python (version 3.8.5) The original contributions presented in the study are included in the article/Supplementary material further inquiries can be directed to the corresponding author were fully informed about the research's purpose and procedures ensuring transparency in the research process Participants voluntarily signed a consent statement explicitly approving the use of their questionnaire responses for research purposes This procedure is supported by the TranSYS Ethics Committee Writing – review & editing RH: Writing – review & editing Belgium; BIO3 - Laboratory for Systems Medicine Department of Public Health and Primary Care Centre for Functional Genomics and Bio-Chips Institute of Biochemistry and Molecular Genetics Faculty of Medicinem University of Ljubljana Luxembourg Centre for Systems Biomedicine (LCSB) Université du Luxembourg; Elle Wilson Université du Luxembourg; Francisco X Spain; Department of Medicine and Life Sciences Universitat Politècnica de Catalunya BarcelonaTech (UPC) Department of Psychiatry and Behavioral Sciences United States; Department Genes and Environment University of Patras School of Health Sciences Laboratory of Pharmacogenomics and Individualised Therapy Greece; Department of Genetics and Genomics United Arab Emirates; Zayed Centre for Health Sciences United Arab Emirates; Erasmus University Medical Centre Department of Pathology—Clinical Bioinformatics Unit Laboratory of Pharmacogenomics and Individualized Therapy United Kingdom; Laboratory of Algorithms for Population Genomics Laboratory of Algorithms for Population Genomics Germany; Laboratory of Bioprocess Engineering Germany; Laboratory of Systems and Synthetic Biology Netherlands; Department of Radiology and Nuclear Medicine The author(s) declare financial support was received for the research TranSYS was funded by the European Union's Horizon 2020 Research and Innovation Programme under the Marie Sklodowska-Curie grant agreement no The authors wish to acknowledge all TranSYS partners who contributed their thoughts and perspectives to this article We want to especially thank our fellow ESRs for making TranSYS the enriching experience it was TranSYS ESRs include: Federico Melograna (ESR1) We extend our gratitude to our principal investigators and mentors for their invaluable guidance over the past years which has been instrumental in fostering the personal growth reflected in this paper: Prof We also express our appreciation to Christina Olsen and RH from Ceratium BV for their companionship and ongoing support throughout our academic journey The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary Material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmed.2024.1348148/full#supplementary-material Exome and genome sequencing: a revolution for the discovery and diagnosis of monogenic disorders 2. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Kristel Van Steen, a3Jpc3RlbC52YW5zdGVlbkBrdWxldXZlbi5iZQ== †These authors have contributed equally to this work and share first authorship ‡Names and affiliations of all consortium partners can be found in Group members in the TranSYS Consortium Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. 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It recently announced that it will launch its “Hinet” service to subscribers in Bali Deals a global leader in the elevator and escalator industry is pleased to deliver vertical solutions to Transmart Carrefour's next project expansions throughout the provinces of Indonesia These projects create a modern shopping experience that bring together hypermarkets Schindler will deliver a total of 474 units including 118 units of the Schindler 9300 Escalator 254 units of the Schindler 9500 moving walks and 102 units of freight elevators As the sole supplier of the elevator and escalator equipment for this project Schindler recognizes the complexity of this multi-mall project With over 51 stores to be developed over a period of two years Schindler has meticulously planned the installation of our products in order to meet Transmart Carrefour's ambitious construction plans Schindler has designed vertical solutions for each project that will efficiently and effectively move people and products to ensure the most comfortable experience possible "It was critical that we partner with a mobility supplier that brings not only impeccable technology but the experience and capability to handle such a sizeable development," said Mr "Strong customer relationships are built based on a consistency in meeting the expectations of our customers We always committed to delivering good quality products and services with zero compromises on safety to the users This partnership with Transmart Carrefour demonstrates the client's trust in us for all their projects and we will deliver as promised to meet their expectations," said Willis Phua the Schindler Group is a leading global provider of elevators Schindler mobility solutions move more than one billion people every day all over the world Behind the company's success are over 60,000 employees in more than 100 countries Berca Schindler Lifts (BSL) was established in 2000 as a joint venture between Central Cipta Murdaya Group and Jardine Schindler Group BSL is headquartered in Jakarta and designs escalators and moving-walks throughout Indonesia Photo - https://photos.prnasia.com/prnh/20171103/1983307-1Logo - http://photos.prnasia.com/prnh/20141111/8521406714LOGO You are using an outdated browser. Please upgrade your browser or activate Google Chrome Frame to improve your experience Woodson is known today as “the father of Black history” and is credited with laying the foundations for the widespread adoption of Black studies in American schools When Woodson founded the Association for the Study of Negro Life and History in 1915 the achievements of Blacks were largely ignored by professional historians Convinced that without a recorded history the contributions of his race would be forgotten Woodson set out to provide a means for the study of Black American heritage Woodson offered scholars a medium for the research and publication of articles on the Black experience Negro History Week (now Black History Month) opened the study of history to the wider public offering information needed to appreciate and understand the role of Blacks in American history Born the son of impoverished former slaves Woodson’s early years were marked by an unwavering commitment to education Forced to work oil his father’s farm and later in the coal mines of West Virginia he was largely self-taught until the age of 19 After graduating from West Virginia’s Douglass High School in 2896 then famous for its acceptance of both white and black students to act as principal of his former high school Woodson divided his time between travel abroad teaching and the continued study of history he worked as a teacher and later as a school supervisor in the Philippines having learned to speak French and Spanish fluently he studied history for one semester in Sorbonne he moved on to Harvard and later to a teaching post at a Washington This position enabled him to pay for his graduate studies and to do research for his dissertation at the Library of Congress he became the second Black man in the United States to receive a doctorate in history Woodson was firmly engaged in the mission to which he would devote his life: the study and documentation of Black history Woodson and a group of four friends sat down in a Chicago YMCA to form the Association for the Study of Negro Life and History (now the Association for the Study of Afro-American Life and History The association was the first historical society devoted exclusively to research on the Black American It was established to encourage scholarly achievement to sponsor research projects and to collect and preserve records documenting the Black past At a time when few Blacks were invited to participate in historical conferences the annual meeting of the association offered black scholars an opportunity to present research papers before their peers the association began publication in 1916 of a scientific quarterly Still recognized as the most distinguished periodical in the field of Black history both in its interpretation of history and in the methods of research used to collect data Woodson encouraged scholars to seek information that had been previously ignored by mainstream historians Quoted in a Journal article by Jacqueline Goggin Lorenzo Green recalled that “Black and also white scholars turned to The Journal of Negro History if they desired to publish findings at variance with the currently accepted views of Black people.” Covering a wide range of topics the Journal led to a shift in the focus of historians from the master’s perspective to that of the slave’s Woodson and other Journal contributors also used census data diaries and oral histories to investigate the Black past Only recently has this method of research been widely accepted by historians Woodson retired from teaching in 1922 to concentrate on his work with the association Obtaining the necessary funds to run the organization was always difficult and Woodson spent much of his life struggling to keep the association afloat Woodson supported the association largely on his teacher’s salary Although for a short period he obtained grants from the Rockefeller and Carnegie funds he was forced in the 1930s — at the height of the Depression — to rely almost solely on contributions from individual Blacks and Black organizations As documented by the American Historical Review at the 1984 issue ceremony of the Carter G “The Association was [Woodson’s] life … To him no task was too small or unimportant if it helped the Association Whether he was scrubbing the office floors or taking books to the post offices for mailing to other historians Woodson immersed himself in the Association’s activities.” Never married the first Negro History Week was established Woodson described the event “as one of the most fortunate steps ever taken by the association.” Expanded in 1976 to include an entire month the national celebration is held each year during the month of February to coincide with the birthdays of Frederick Douglass and Abraham Lincoln essays and poetry contests are held during Black History Month to dramatize the achievements of Blacks and to encourage black children DuBois commented that Woodson “literally made this country which has only the slightest respect for people of color a week in which it studied the effect which the American Negro has upon life built up such a national celebration” thought and action in the United States With the establishment of Black History Month Woodson saw a need to publish a journal more closely associated with schools and one that simplified the study of history for the average reader Woodson founded the Negro History Bulletin Woodson devoted himself to directing the association publishing its journals and editing the six-volume Encyclopedia Africana The Minnesota Timberwolves (33-29) are home in Northwest Division play versus the Utah Jazz (15-45) on Sunday which includes the Tampa Bay Lightning versus the Florida Panthers Top 25 teams will take the court across two games on Monday’s college basketball schedule The college basketball schedule on Monday should provide some fireworks Our computer model has provided picks against the… Ranked teams are on Monday’s college basketball schedule for two games including the Kansas Jayhawks squaring off against… Each new distributor is an established heavy lifting service provider in important markets throughout the region — MIPEC Technologies JSC in Vietnam and General Machinery Technology in Myanmar The four new distributors each come with varied and extensive experience in the supply service and maintenance of heavy lifting equipment is one of the 500 largest companies in Vietnam and signed the agreement with Konecranes in February 2018 TIQE Cambodia Equipment mainly serves the autonomous port and has many years of experience with the Linde line of container lifting equipment — which Konecranes acquired selected product rights for in 2013 making a natural pathway to the two companies partnering PT Berca Mandiri Perkasa has an excellent reputation for heavy equipment trading and mechanical-electrical contracting and has been a long-established dealer for the Terex brand — which Konecranes also acquired in 2017 General Machinery Technology was established 10 years ago and specialises in servicing heavy lift customers in the ports and container depots in the fast-growing economy of Myanmar Mr Patrik Lundbäck of Konecranes Lift Trucks commented: “As a company we are incredibly proud of our broad-based manufacturing capabilities in Asia it is only fitting that our Asia dealership network also grows in order to better leverage that capacity “We look forward to a prosperous future with our new partners in Asia.”  DP World is set to implement OneStop Modal and the OneStop Vehicle Booking System (VBS) The US House of Representatives has voted to overturn the Environmental Protection Agency‘s (EPA) 2023 global schedule reliability surged to 57.5 per cent Container throughput at the Port of Melbourne totalled 267,000 TEUs in March 2025 Cover image: ©Associated Press The death toll has risen to at least 70 here are five reasons you cannot miss Episode 10 this Thursday There won’t be any guest athletes appearing in this episode’s physical challenge but they aren’t needed this time around – the ONE Chairman and CEO has it covered Chatri will put on his cleats and show his soccer skills when, together with the five candidates, he’ll play alongside the kids of Boys’ Town in Singapore a foundation close to the Thailand native’s heart Fans have already seen the craziest challenges from dragon boat races to mock-helicopter crash escapes And while this isn’t as wild as the other physical tasks getting to know Chatri on a personal level while sharing time with those he cares about is as good as it gets Dropping by the show to act as guest advisors this week are Indonesian billionaire brothers Karuna and Prajna Murdaya Karuna is the Director of the Central Cipta Murdaya (CCM) Group an Indonesian conglomerate holding a business portfolio worth US$7 billion that owns businesses in infrastructure Before becoming the Director of Jakarta International Expo and Berca Sportindo he was a vocalist on the Stanford Fleet Street Singers it’ll be interesting to see what the candidates take away from the duo’s eclectic portfolio of skill sets Whether the cancer survivor manages to keep his position on the show for one more week or leave the remaining four women to contest the outcome between themselves will be revealed in Episode 10 The first nine episodes have revealed most of the candidates’ motives, but perhaps one of the most notable side stories of the show is the alliance between American Monica Millington and Russian Irina Chadsey The “MoRina” alliance began when both women were part of Team Valor where they created a solid partnership and smartly navigated the challenges in a way where they could excel and separate themselves from the other candidates However, after Irina was moved to Team Conquest in Episode 7 the two were forced to work together from different teams Now that the group of global candidates has been narrowed down to five will Irina and Monica reunite in Episode 10 Paulina Purnomowati has been one of the most consistent candidates on “The Apprentice,” but that doesn’t mean she’s immune to criticism Paulina previously worked as the country manager for a multinational fashion and beauty retailer a field the Murdaya brothers are familiar with this could be Paulina’s chance to stand out BUY NOW 2019 /PRNewswire/ -- PT Berca Schindler Lifts (BSL) held a ceremony to mark the graduation of its first-batch apprentices and welcome the second batch of the program The Apprenticeship Program has been running for over two years and jointly developed with BBPLK Bekasi (Balai Besar Pelatihan Kerja) a leading vocational training institute in Indonesia The program incorporates specialized skills that needed in the lift and escalator industry apprentices also obtain work rotations across our Schindler operational businesses to provide them with real world work experiences PT Berca Schindler Lifts' President Director Thibaut Le Chatelier and Head of BBPLK Bekasi Herman signed the joint declaration of intent for the second batch at BSL headquarter "Schindler consistently commits in people development to ensure the best service in term of safety quality and reliability to our customers and all passengers using our solutions every day We are delighted to continue this partnership program with BBPLK Bekasi to bring us a pipeline of young talents into the technical stream of business and meet the requirements of Industry Revolution 4.0," said Thibaut Le Chatelier BSL conduct a comprehensive training in its largest Knowledge Center.  Herman Head of BBPLK Bekasi had also added "Human resources development will be key to Indonesia's future for the next 5 years We are very pleased to be able to develop a very practical program with industry leaders like Schindler – to tailor the curriculum into electrical and mechanical disciplines of courses to ensure that apprentices are able to apply what they learn from the classroom straight into a real-world work environment." BSL named as Indonesia's 'HR Asia Best Companies to Work for in Asia 2018' and became the only one elevator and escalator company nominated by HR Asia BSL also developing digital technology called 'Schindler Ahead' to connect machine PT Berca Schindler Lifts (BSL) was established in 2000 as a joint venture between Central Cipta Murdaya Group and Jardine Schindler Group – a leading global mobility provider of elevators Schindler supports sustainable urban development with safe and reliable mobility solutions Behind the company's success are over 65,000 employees operating in beyond 100 countries a leading global elevator and escalator company today announced the installation of its groundbreaking myPORT mobile application at MD Place in Jakarta The upgrade to the building's elevator and transit management system now offers users a world-class level of building navigation MD Place is a premium office for the country's leading multimedia and television company MD Corp The building with its remarkable prismatic facade contains Schindler's elevators and groundbreaking PORT Technology transit management system myPORT is an intuitive smartphone-based application for personal mobility and an extended feature of the PORT Technology -- Schindler's third generation Destination Control System As soon as an occupant enters the building myPORT detects his smartphone and activates a four-step "e-banking level" security check to verify his credential and access level The occupant simply unlocks his smartphone and presents it to a PORT terminal and a Schindler elevator would then be automatically assigned to take him to his floor there is a very high degree of confidence that the owner of the smartphone has the right to be there pre-programmed elevators assigned and life in general made much more convenient all without taking the smartphone from one's pocket "Users now have more freedom and convenience than ever before while building owners have greater access control and higher security standards," said Calynn Tan Transit Technologies Director for Jardine Schindler Group "For visitors who don't have the app installed myPORT users can grant them temporary building access through generating an SMS message linking to a unique video access code Visitors can simply show this code to the PORT terminal in order to gain entry," she said "We are very proud to partner with MD Place to successfully implement the revolutionary myPORT technology in the building," said Willis Phua President Director of PT Berca Schindler Lifts "As the lives of office workers in burgeoning cities like Jakarta continue to become busier and more complex we are always developing ways to keep these environments running smoothly We look forward to seeing its unique benefits in action in Indonesia bringing a welcoming and secure environment to occupants and visitors," he said "myPORT's e-banking level authentication meets the highest international standards of security to make users feel comfortable," said Manoj Punjabi "It also makes moving around the building fast and easy Berca Schindler Lifts -- the home of Schindler in Indonesia Schindler's myPORT technology has been seamlessly integrated with MD Place's vertical transportation system allowing a seamless and secure transit throughout the building's office and restaurant floors via its cutting-edge smartphone app PT Berca Schindler Lifts (BSL) officially announced the strengthening of its position by expanding its footprint into the Central Java area a fourth branch has been opened and reaffirms almost 20 years of commitment to providing Indonesian customers with vertical transportation solutions this further supports BSL's ambition of being the region's leading elevator and escalator provider described Schindler's pivotal role in Indonesia's fast-growing infrastructure and property development Schindler offers a wide range of vertical mobility solutions Yogyakarta is well known as a destination for tourists and home to a large student population it is essential that people have a safe and efficient solution to move conveniently throughout these buildings The Yogyakarta branch is a mark of the long-term commitment of Schindler in Indonesia.  BSL will bring the same excellent standard of service to this branch as it has with its other three To ensure Schindler's products and maintenance services are safe and reliable -- BSL is dedicated to people development through their comprehensive training centre The Knowledge Center is equipped with 3 training shafts 9 training rooms and several training simulators Furthering its maintenance service capabilities Schindler is at the forefront of digital and innovative technology solutions that connect our products technicians and call centres for an improved passenger experience "We are absolutely sure we have chosen the right partner Schindler not only delivers highly advanced products but also reliable service for our projects," said Surya Ananta Behind the company's success are over 64,000 employees in more than 100 countries PT Berca Schindler Lifts (BSL) was established in 2000 as a joint venture between Central Cipta Murdaya Group and Jardine Schindler Group -- a leading global mobility provider of elevators Photo - https://photos.prnasia.com/prnh/20190328/2417325-1-a Photo - https://photos.prnasia.com/prnh/20190328/2417325-1-b Logo - http://photos.prnasia.com/prnh/20141111/8521406714LOGO Atmojo is the general counsel of data centre colocation and hybrid cloud solutions provider BDx Indonesia he worked as an in-house counsel in a wide range of companies including Berca Carrier Indonesia and Indosat Having assumed the role of general counsel at BDx last year he believes he could not have joined the company at a more opportune time given the rapid rise in the importance of data security EDITOR'S NOTE: If you're a general counsel based in Asia who'd like to be featured in this series please email mari.iwata@tr.com and ranajit.dam@tr.com ALB: What have been some of your highlights from your time in charge And what are some leadership lessons you have learnt Setiawan: There are many highlights to share regarding my legal career but the one that stands out the most is learning to successfully navigate the challenges that come along with working in the digital infrastructure industry such as the fierce competition and the demand for timely responses and precise execution proactive legal support system is key to BDx to thrive in this industry and I am very proud of our legal team and the world-class expertise we provide how do you participate in your company’s business we are dealing with a crowded marketplace where we have to stand out if we want to succeed needs to live and breathe the BDx value proposition going the extra mile to contribute to the organisation's success I am fully committed to engaging with all team members to ensure we meet our customers’ needs ALB: How would you describe your strategy for the legal team We stay laser-focused on the needs of the customer and to ensure BDx is providing the best data centre and colocation services we also need to provide the best legal services to support company goals We carefully and effectively navigate regulatory complexities and identify risks and liabilities to get the best results possible Our legal team helps the company take its strategies from the very early stages of development through the execution phase — ensuring the efforts are supported along every step of the journey with a sound locally and globally compliant legal framework ALB: How important is the company’s culture What kind of internal culture are you looking to foster both within the team Setiawan: Company culture is vital to the success of an organisation and the individual teams within it It all comes down to people; keeping employees engaged can go a long way to boost productivity and retain and attract new talent I encourage an open dialogue with employees to help them feel comfortable sharing their ideas and to keep the stream of communication flowing We also take part in team-building activities and regular check-in meetings This helps us build stronger relationships understand each other better and overcome challenges when conflicts occur how would you describe your hiring and talent retention strategy What kinds of lawyers would make the best fit for your team Setiawan: I have always believed the best lawyer is not the smartest but the one who delivers There is no point in having genius lawyers on your team if they can’t step in and do the work to solve problems for the company a talent retention strategy doesn’t have to be driven by compensation and benefits It can be driven by the recognition of achievements the ability to develop employees’ strengths being open to honest feedback and acting on it for continued improvement ALB: What kind of compliance system have you established for your company Setiawan: We have established a robust compliance system at BDx allowing the entire company to work within the same standards same understanding and the same mechanism for more efficiency and productivity Operating in multiple locations across APAC the universal system helps us maintain due diligence processes that comply with various local regulations across the region ALB: How would you rate the current standard of legal services available in your jurisdiction Setiawan: The current standard of legal services available in our jurisdiction is quite satisfactory We work with reputable firms that are customer-focused and provide fair and accurate legal opinions pricing could be adjusted to better meet the needs of clients from a financial standpoint ALB: How have your legal requirements evolved in recent times How does that change the way you use external counsel and other legal services providers I think legal requirements evolve only when the regulation changes legal requirements did not change as a result of the pandemic The need to use external counsel during the pandemic increased only slightly as the in-person working environment was impacted such as representing a company before the court ALB: When it comes to cooperating with external lawyers what qualities or capabilities do you believe are the most critical to not only the work itself but also a sustainable long-term cooperating relationship it is most important for a lawyer to have a thorough understanding of three major factors: business a lawyer will be able to build a sustainable long-term relationship with the client because they will see them and trust them as a true business partner ALB: Where would you like to see the team five years from now Setiawan: Five years is an eternity in tech our team will continue to be an integral part of the organisation independent legal support that elevates BDx to greater heights in the Asia-Pacific region and across the globe talks about what it means to shift from reactive to proactive legal work why balancing robust legal protection with startup agility is crucial in early-stage investments and how adapting to India's evolving startup ecosystem requires empathy head of legal and commercial Services at Malaysia's Sime Darby Property talks about why in-house lawyers must master both legal and financial literacy what it takes to resolve a potential five-year IP dispute in just three months and how channelling Kelly Clarkson's "what doesn't kill you makes you stronger" mindset helps maintain positivity while leading a legal team External and Legal Affairs at Microsoft Asia talks about why changing roles every five years keeps you learning what factors will drive success in the AI era and how he envisions Asia leveraging AI for good in the near future Stay up to date with the latest trends in Asian Legal issues Asian Legal Business (ALB) is owned by Thomson Reuters the world’s leading source of intelligent information for businesses and professionals Copyright © document.write(new Date().getFullYear()) Thomson Reuters the international private equity fund with 20 years of experience in emerging markets acquired a 98 percent stake in Brikston Construction Solutions SA (Brikston) in July 2014 and has agreed to sell its full shareholding to Wienerberger AG of Austria ADM Capital invested in Brikston through its flagship CEECAT Recovery Fund launched in 2011 This represents another in a series of recent exits for the CEECAT Recovery Fund a preparation for the launch its follow-on CCL CEECAT Fund II in early 2018 The completion of the transaction requires the approval of the competition authority; pending such approval the two companies will continue to conduct their businesses separately They agreed not to disclose the purchase price The headquarter of the company is in in Iasi and generated sales of around EUR 16 million in 2016 with its large distribution network targeting most of Romania ADM Capital acquired Brikston in July 2014 and has improved operating profit by more than 60 percent during its three years of ownership. ADM Capital was advised within the transaction by law firm RTPR Allen & Overy We use cookies for keeping our website reliable and secure providing social media features and to analyse how our website is used A mysterious boy that Van and company encounter at a certain place live-in-the-moment-type personality that shows signs of insanity in his light tone He is a cunning fighter who utilizes a magic silver long rifle as his weapon and can change the trajectory of his magic bullets with his special abilities He has been working behind the scenes in various parts of the Republic by the orders of Ellroy Harwood but his relationship with Harwood beyond that and personal history remain shrouded in mystery A mysterious girl who the members of the Solutions Office encounter at a certain place She mostly keeps to herself and is hesitant to do anything she is not required to do also shows signs of insanity in different ways from her brother Despite the fact that she is not very physically strong she uses her powers to summon a giant hand made of “shadows,” and uses it at her will to demonstrate a level of combat that can easily overwhelm the average Jaeger she seems to be acting behind the scenes in the Republic who acts behind the scenes as leader of the remnants of “Garden,” a viscous assassins organization that cooperated with the mafia organization Almata in the past Although somewhat arrogant and self-absorbed with his own actions he is highly skilled with the two special greatswords he wields He seems to have come in to power after Swin and Nadia left Garden and neither of them were told of his existence He seems to have some connection to Grendel-Zolga and Hollow Core AI Altera which appear to be the cause behind the bizarre murders in Edith… A teacher who came to Aramis High School as a substitute from the Erebonian Empire’s Thors Military Academy she is also a member of a non-governmental organization (NGO) and is concerned about the poverty and environmental problems across the land she is extremely wise and has a strong sense of responsibility and has accomplished many operations and negotiations since her days as a student She and her schoolmates have witnessed countless “behind the scenes events” in the western side of the continent so it is suspected that there is a reason behind her arrival in the Republic… Sherid Asverl (voiced by Shunsuke Takeuchi) The first prince and son of Grand Prince Saruman of the Principality of Elsaim which is a Middle-Eastern country that honors its traditions Although he has a noble atmosphere worthy of a prince and enjoys interacting with people of different classes He is very knowledgeable when it comes to the arts and culture and formed a connection with Van and company during the Tharbad Film Festival When it comes to navigating international affairs as a noble The princess of the Principality of Elsaim and Sherid’s younger sister and while Sherid has described her as “a sister who has accomplished more than I,” she has a great deal of respect for her brother she can also sometimes bury herself in fantasies just like any other girl her age She seems to get along with her friendly brother and they share common interest such as orbal cinema A woman in black who acts as Prince Sherid’s royal guard and secretary She uses a weapon known as the Gun-Shamshir which is a Middle-Eastern traditional curved sword equipped with an orbal unit and is known as one of the best royal swordsmen in the Principality While Sherid trusts her greatly as a loyal subject who carries out her duties quietly and precisely she often has to scold him due to his frivolous behavior outside the country She usually acts as Sherid’s royal guard but because of that trust sometimes takes on the role of his sister Zita’s guard and assistant View a new set of screenshots at the gallery Reproduction in whole or in part in any form or medium without acknowledgment of Gematsu is prohibited Use of this site is governed by all applicable laws Website by 44 Bytes arrow leftarrow rightarrow rightPower & Purpose   |   Asia's Most Influential IDMetta MurdayaFounder Metta Murdaya was working in New York City She had just finished her MBA from NYU Stern School of Business Her busy schedule had taken a toll on her skincare regimen and a near-fatal car accident urged her to take a moment to pause Murdaya re-evaluated her approach to wellness Tinkering with concoctions with her friends in their kitchen a natural skincare line inspired by the Indonesian tradition of jamu Jamu is an age-old tradition that creates tonics and formulas for beauty rituals taken from natural ingredients such as herbs The main ingredients in Murdaya’s beauty products include turmeric Murdaya published the book Jamu Lifestyle: The Indonesian Herbal Wellness Tradition She is the daughter of Murdaya Poo and Siti Hartati Murdaya Murdaya graduated from the University of California at Berkeley Murdaya is a certified acro yoga instructor UNWIRED, Singapore’s first and only independent wireless and mobile conference, returned for a second run last Thursday and saw the attendance of top-level executives from the relevant industries from across Southeast Asia Opened by the Infocomm Development Authority’s assistance chief executive Khoong Hock Yun it featured half a day’s discussion on hot topics affecting the industry and its users From Singapore’s expected move to next generation mobile broadband (4G/LTE) to the rise of mobile computing and winning features of a mobile operating system the conference was packed with fresh insights from a who’s who list of the country’s industry experts who fielded a number of questions from the audience Of particular interest was the first panel which starred Chan Kin Hung (head of products and solutions at Starhub) Chan Yim Leng (vice-president for consumer products at SingTel) Raymond Tan (former CEO of Berca Global Access) and Remus Tan (director of mobile networks from Tellabs) The discussion centered on the upcoming 4th generation of cellular wireless standards Some telcos, for instance in the US, have branded their networks as 4G, but there is currently no system which meets the 4G standards set by the International Telecommunication Union (ITU), although there are viable candidates True 4G standards will be able to deliver all content over IP and provide a completely different user experience SingTel and Starhub are already conducting LTE technical trials according to StarHub’s Chan Kin Hung SingTel’s Chan Yim Leng also cited the importance of establishing a regulatory environment as an important factor to get things going The idea is thus for telcos to jointly roll out LTE with manufacturers and governments the issue in many developing countries like Indonesia the closest thing to mobile broadband is GPRS” but it can deliver stable rates of 1 to 2 Mbps Both telco panelists expressed that Singapore has no use of WiMAX and that 3G is a more suitable standard locally The conference then moved on to the rise of mobile computing with a second panel made up of hardware makers Motorola’s vice-president for mobile devices for Asia called the new trend “converged computing” the rise of tablet devices has many people using computers when many have not even owned a desktop in their lives it is agreed that two largest issues facing mobile computing the battery life of devices and consumer education in the devices’ usage most smartphones can barely last a day in usage Consumers will also benefit from tips on how to get the most out of their new toys What will a winning mobile OS look like in the future iOS was the dominant mobile OS; now that crown belongs to Android people-centric communication and the ability to build an ecosystem around the OS are important But to a hardware manufacturer like Samsung regardless of platform” is the most important factor Customers must identify with the brand and stick with it even if they decide to jump platforms and this is something hardware manufacturers must work towards The day culminated in a networking session at the hotel bar with the first round bought by one of UNWIRED’s main sponsors Tellabs (Never say no to free beer!) It was enlightening to listen to speakers who would not otherwise talk about what their companies are up to and what’s next for the industry This site uses Akismet to reduce spam. Learn how your comment data is processed. Started in June 2008 by technology journalists and ex-journalists in Singapore who share a common love for all things geeky and digital the site now includes segments on personal computing