Volume 11 - 2024 | https://doi.org/10.3389/fnut.2024.1445955
Nutraceuticals are gaining popularity as they can contribute to bone health by delaying the onset or slowing down the progression of pathological bone loss
Osteoporosis’s bone loss is a concern for older adults and a crucial aspect of aging
Maintaining healthy bones is the key to living a full and active life
Our review explores the current knowledge on the role of nutraceuticals in preventing osteoporosis by focusing on three main aspects
we discuss the latest findings on natural nutraceuticals and their efficacy in reducing bone loss
we conduct a structured analysis to evaluate nutraceuticals’ pros and cons and identify translational gaps
we must address several challenges to consolidate our knowledge
better support clinicians in their prescriptions
and provide people with more reliable nutritional recommendations to help them lead healthier lives
Osteoporosis is a common, debilitating, chronic, progressive, systemic, and metabolic skeletal disease. Bone loss is not just a concern for older adults but a crucial aspect of aging. Maintaining healthy bones is the key to living a full and active life (1–3)
Several compounds that fall under the definition of nutraceuticals can complement pharmacological treatments aimed at increasing bone mineral density and preventing bone tissue loss (7, 8)
Our literature review will highlight the latest developments in natural nutraceuticals that promote bone health and prevent bone loss
we will analyze nutraceutical pros and cons
Bone is a mineralized connective tissue exerting essential functions: muscle attachment and locomotion, soft tissue support, vital organ protection, bone marrow harboring, calcium (Ca) and phosphate (H3PO4) storage, and homeostasis (9)
Mature bone tissue includes an abundant calcified extracellular matrix (ECM) that supports and interacts with the resident cell types contributing to bone development and maintenance: osteoblasts
Mesenchymal stem cell (MSC)-derived osteoblasts serve for bone formation; osteocytes are terminally differentiated mature osteoblasts embedded in the mineralized bone, no longer involved in bone formation, but helping control the remodeling process. Osteoclasts, derived from hematopoietic precursors, degrade mineralized ECM (bone resorption). Bone lining cells are quiescent osteoblasts localized at bone surfaces, where bone resorption and bone formation do not take place (9)
Besides cells, the ECM comprises a nanostructured organic phase rich in collagen (mainly type I collagen, mucopolysaccharides, and water), which provides flexibility and tensile strength, and an inorganic mineral phase presenting nanocrystalline hydroxyapatite (Ca and H3PO4), which ensures bone mechanical rigidity and compressive strength (10–12)
Resorption and formation are the two main phases of bone remodeling involving mechanical and chemical signals together with systemic and local endogenous factors that can act synergically or antagonistically. Dis-regulations within this complicated functional network can handle pathological conditions or diseases and thus be the target of the treatment (13, 14)
Risk factors can be unmodifiable or modifiable or associated with concomitant diseases or the use of specific drugs that can cause bone loss (23)
osteoporosis prevails in Caucasian and Asian populations than in African and Hispanic ones
Osteopenia and osteoporosis occur when BMD decreases due to an osteo-metabolic imbalance that disrupts the microarchitecture of bone tissue (31)
The third decade of life marks the peak of bone mass
and the exact age varies with gender and skeletal site
and the loss can reach pathological levels
Osteopenia indicates a BMD value lower than the average reference but not low enough to reach the diagnostic criteria of osteoporosis (32). Osteoporosis affects approximately 200 million women worldwide, often resulting in painful fractures (33). A high fracture risk involves about 23 million people in the European Union (34)
Primary osteoporosis forms are related to female post-menopausal state (Type I) due to estrogen deficiency or advancing age (Type II) in men and women. Secondary osteoporosis derives from pre- or co-existing pathologies, medical conditions, or medications interfering with physiological bone formation (35)
According to the World Health Organization’s (WHO) indications, osteopenia diagnosis relies mainly on BMD evaluation by densitometric investigation. The dual-energy x-ray absorptiometry (DEXA) technique at the lumbar spine, proximal femur, or total hip is recognized as a standard diagnostic criterion (39)
However, screening programs with standard DEXA in women over 50 are primarily available in Western countries (40); in men
a diagnosis is usually made only when a fracture occurs
Other imaging techniques are quantitative computerized tomography, quantitative ultrasound, and conventional radiology (41, 42)
The first approach for treating osteoporosis is correcting or eliminating the “modifiable risk” factors. A dietary intake or supplementation with vitamin D and Ca is usually suggested (43) as a prerequisite for drug treatment
Therapies for osteoporosis can exert several adverse effects, such as gastrointestinal irritation, musculoskeletal discomfort, and bone pain. However, rare but severe adverse effects can occur upon long-term exposure or high doses, like osteonecrosis of the jaw or atypical femoral fractures (45)
The concept of health has evolved to emphasize a decreased risk of developing diseases rather than being a illness-free state. This shift has also brought attention to the protective and preventive role of healthy nutrition, conveying confidence in the benefits of nutraceuticals and increasing the demand and supply (46–51)
Nutraceuticals are a vast, non-uniform, and ever-expanding group. They can be natural/traditional (directly derived from natural sources) or unnatural/non-traditional (artificially synthesized through agricultural breeding or biotechnology) (53)
Six main nutraceutical groups are beneficial for bone health: minerals, herbs, phytochemicals, dairy products, probiotics and prebiotics, dietary lipids, and melatonin (Figure 1). In the following paragraphs, we will resume the updated existing literature (54)
This group includes essential human nutrients
The 90% of Ca is in bones and teeth as salt. This mineral is crucial for the growth and development of the skeleton, bone mineralization, and achieves peak BMD during adolescence (55). Ca also plays a crucial role in enhancing the effectiveness of bisphosphonates (56). Oxalic and phytic acids in some foods and high sodium consumption can hinder Ca absorption (57)
Ca is key in bone regeneration pathways, including Wingless (Wnt) and β-catenin. Wnts can mediate antagonism of β-catenin signaling through Ca-dependent or independent mechanisms. Additionally, Ca participates in the crosstalk between β-catenin-dependent and independent pathways (58)
Like Ca, Mg can activate the β-catenin pathway and the Wnt signaling of human bone marrow MSCs (BMSCs), promoting bone regeneration. Moreover, by regulating RANK and RANKL, Mg supplementation could prevent bone resorption while promoting bone formation (58)
Phosphorus (P) is predominantly found in bones and teeth in the hydroxyapatite form (mostly Ca hydroxyapatite)
which regulates bone cell cycle and metabolism and alters signal transduction pathways and gene expression
High PO43− levels, in concomitance with low Ca intake, induce an increase of PTH, which, in turn, mobilizes Ca from bones (62). Excessive PO43− intake or hyperphosphatemia can lead to ectopic calcification and has been linked to various health issues, including bone disorders. Therefore, maintaining an appropriate PO43− balance in the body is crucial for overall bone health (58)
Potassium (K) balances the endogenous acids produced by acid-generating foods like meat, maintaining an alkaline environment. This mechanism helps preserve bone Ca, which is available for mobilization to maintain normal pH. Therefore, consuming foods that are rich in K can help prevent Ca loss from the bone (62)
Zinc (Zn) activates osteoblasts, favoring collagen synthesis and alkaline phosphatase activity. It can influence β-catenin signaling, evidenced by activating the Wnt pathway components Axin2 and LRP5. The osteoclast gene RANKL is also upregulated, suggesting Zn’s ability to regulate osteoclastogenesis (65). At least 20% of people are at risk of Zn deficiency, which correlates to osteoporosis (66)
Boron (B) is present in high concentrations in bone. It has beneficial effects in combination with Ca, Mg, and vitamin D. It boosts the half-life of vitamin D and estrogen, preserving them and preventing Ca loss and bone demineralization (67). Deficiency of B is associated with osteoporosis, possibly by modulating the Wnt/β-catenin pathway (58)
Copper (Cu) is involved in collagen fibril formation, angiogenesis, and osteogenic differentiation (62, 68, 69). It is a cofactor for antioxidant enzymes and destroys free radicals (70)
Cu has been found to play a role in activating the β-catenin signaling pathway and in down-regulating Wnt signaling (58)
Phytochemicals are chemical bioactive components of nutrient plants that may provide desirable health benefits beyond nutrition. They can reduce the risk of osteoporosis. Phytochemicals include several compounds: terpenoids, polyphenols, alkaloids, organosulfur compounds (OSCs), and phytosterols (71)
Curcumin (Cur), a polyphenolic chemical constituent derived from turmeric, can help prevent bone loss by reducing NF-κB, Wnt/β-catenin, RANKL, and tumor necrosis factor-alpha (TNF-α) (72–74), and enhancing the differentiation of osteoblasts from adipose tissue-derived human MSCs through inhibition of Wnt/β-catenin signaling (75)
Cur is a powerful antioxidant that prevents bone weakening by removing harmful molecules and reducing cell death. It achieves this by activating protein kinase B (Akt) to reduce the activity of glycogen synthase kinase-3 beta (Gsk3β), reducing the activity of a critical protective protein, nuclear factor-like 2 (Nrf2) (75)
Cur plays a role in bone resorption by blocking the differentiation of osteoclast precursors into osteoclasts by inhibiting the production of the chemokine CCL3
Cur inhibits osteoclast differentiation markers
Cur exerts immunomodulatory effects on macrophages by inhibiting inflammatory responses, reducing the release of inflammatory factors, and preventing osteoclast formation by improving Akt/NF-κB/NFATc1 signaling (76–81)
Medicago sativa L. is a native plant of Eurasia that contains ipriflavone, which inhibits bone resorption, enhances osteoblast proliferation, induces estrogen-mediated calcitonin secretion, and strengthens estrogen-protecting action on bones (82, 83)
Red clover is the extract from Trifolium pratense L. It contains genistein and diadzein, phytoestrogens with structural similarity to estrogen, thus preventing bone loss (84, 85)
Also known as horsetail, equisetum is a plant that grows naturally in the northern hemisphere. It contains silica, flavonoids, and triterpenoids, all beneficial for bone health (86, 87)
Citrus fruits contain carbohydrates, fiber, minerals, vitamins A, E, and B, and antioxidants such as flavonoids, vitamin C, phenolic compounds, and terpenoids (88)
Polysulfides in Alliaceae, glucosinolates, and isothiocyanates in Brassicaceae have anti-inflammatory, antioxidant, vasorelaxant, and hypolipemic potential. These compounds can induce osteoblast and reduce osteoclast activities by releasing hydrogen sulfide, a gasotransmitter (97)
Flavonoids and organo-sulfur conjugates are present in onion (Allium cepa L.), which offers numerous bone health benefits (98), including inhibiting bone resorption (99, 100) and positively modulating BMD in peri- and postmenopausal women (101)
When administered in tablet form over 30 days, garlic (Allium sativum) can decrease oxidative stress in menopausal women, which may reduce osteoporosis onset and progression (102). Garlic and leek can also suppress bone resorption (103, 104)
Herba Epimedii is a traditional Chinese medicine that contains icariin. This flavonoid glycoside can arrest inflammatory bone loss by inhibiting osteoclastogenesis-induced lipopolysaccharide, TNF-α, and IL-6 and producing type-2 cyclooxygenase and prostaglandin E2 (106)
Berries contain vitamins A, B9, C, E, and K, minerals, and carotenoids, and are rich in fumaric and citric acid. Berries possess antioxidant (107) and anti-inflammatory properties and can improve osteoblasts differentiation
raspberry trans-retinoid acid and ketones stimulate osteoblast differentiation by improving osteocalcin expression in stem cell cultures
In addition, berries contain phenolics like flavonoids (anthocyanins, flavonols, and flavanols), phenolic acids, proanthocyanidins, ellagitannins, gallotannins, and stilbenoids. Anthocyanins seem to inhibit RANKL and osteoclastogenesis (108)
Dried plums contain carbohydrates, vitamins A, B, and K, Ca, K, Mg, boron, selenium, dietary fibers, and polyphenols, such as chlorogenic acid, rutin, and proanthocyanidin. Polyphenols decrease bone resorption, acting on RANKL signaling (109). Administering dried plums to postmenopausal females increased insulin-like growth factor 1 (IGF-1) and bone-specific alkaline phosphatase (BSAP) levels (110)
Resveratrol (RSV) is a polyphenol in red wine
RSV functions as both anabolic and antiresorptive agent. Indeed, RSV is a SIRT1 activator or directly acts on Runx2 and Osx to regulate osteoblast differentiation; it also activates Runx2 and OSX expressions, RANKL/OPG, NFACT1, and NF-kB expressions to regulate osteoclast differentiation. In addition, it displays antioxidant and anti-inflammatory features (111, 112)
These dual actions of RSV on osteoblast and osteoclast are beneficial in maintaining balance in bone remodeling, a critical endpoint in the management of osteoporosis (113)
Gut microbiota (GM) is a complex microflora consisting of millions of microbes in humans. Under physiological conditions, GM lives in a balanced state known as eubiosis, forming multidirectional connections with other organs such as the brain, gut, and bone axis while interacting with many pathways (123, 124)
and polyunsaturated (PUFAs) fatty acids based on the double bond number and common chain length
Animal-based food is the primary source of nutrition for SAFAs
High-fat diets (HFD), particularly those rich in saturated fatty acids (SAFA-HFD), can harm bone health. These diets can lead to an imbalance between bone resorption and formation, as well as an increase in DNA damage, potentially contributing to bone loss (145)
Oxidative damage is responsible for high osteocyte apoptosis in SAFA-HFD-fed animals compared to those fed a standard diet; micropetrosis and the canalicular system disruption cause this, leading to bone fragility. Moreover, SAFA-HFD strongly inhibits osteoclast apoptosis in IL-6-deficient mouse models. Consequently, survival of osteoclasts and apoptosis of bone-forming cells may lead to osteoporosis (145)
MUFAs are abundant in nuts, avocados, olive oil, and canola (rapeseed). Olive oil, one of the essential foods in the Mediterranean diet, contains MUFA in the form of oleic acid. In extra virgin olive oil (EVOO), phenolic compounds are also present, which have a beneficial role. Fat from meat also contains MUFAs and SAFAs but is not recommended as a good source of MUFAs (146)
To enhance bone health in advanced age, dietary oils rich in the n-6 fatty acid gamma-linolenic acid (GLA) can be combined with the n-3 PUFA EPA to reduce PGE2 synthesis and enhance PGE1 production, which has anti-inflammatory effects. Decreasing the amount of n-6 PUFAs allows the manipulation of endogenous prostaglandin synthesis (145)
In animals fed with PUFA-rich diets, n-6 and n-3 PUFA may interact with PPAR-γ to inhibit osteoblast differentiation and promote the adipocyte one (145)
Animals fed with MUFA-rich diets had superior BMD values to those fed n-6 PUFA-rich diets. However, PUFA-rich diets were more beneficial to bone than SAFA-rich diets (145)
PUFA or HFD-SAFA-rich diets increase ROS production in growing mice compared to other unsaturated fat alimentations. This activates osteoclasts and inhibits osteoblast maturation through NF-κB, enhancing adipogenesis (145)
Melatonin (Mel) is a bioamine (N-acetyl-5-methoxytryptamine) secreted and released by the pineal gland at night. It controls circadian rhythms, body temperature, reproduction, immune and cardiovascular systems, energy, and bone metabolism. Mel predominantly acts through its cognate receptor, Mel receptor 2 (MT2R), expressed on MSCs, osteoblasts, and osteoclasts (150)
Mel has been shown to have an anti-osteoporotic effect since it induces beneficial effects on bone tissue. Altered levels of Mel are associated with the occurrence and development of osteoporosis in postmenopausal women (151)
Mel can enhance the osteogenic differentiation of BMSCs and retards bone loss through the HGF/PTEN/Wnt/β-catenin axis in OVX mice. Additionally, HGF diminished the expression of PTEN, resulting in an activated Wnt/β-catenin pathway both in vitro and in vivo (155)
Mel promoted BMSC-mediated osteogenesis-angiogenesis coupling in OVX rats with tibia defects as an osteoporotic model. Mel also promoted angiogenesis by upregulating VEGF levels and enhanced the expression of the typical osteogenesis and angiogenesis-related markers compared to the untreated group (156)
In a rat model for glucocorticoid induced osteoporosis, high doses of dexamethasone caused BMSCs to undergo ferroptosis, a programmed cell death that depends on Fe. The prevention of osteoporosis was demonstrated by early Mel inhibition of the ferroptosis pathway. Indeed, Mel was able to block the phosphatidylinositol 3-kinase (PI3K), protein kinase B (AKT), and mammalian target of the rapamycin (mTOR) axis that controls bone metabolism (158)
In the type 2 diabetic osteoporotic mouse model, high glucose triggers ferroptosis by increasing ROS, lipid peroxidation, and glutathione depletion. However, administration of Mel can inhibit ferroptosis by triggering the nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) signaling pathway. This helps improve the osteogenic capacity of osteoblasts. These findings have been confirmed through in vitro experiments (159)
For a detailed update on the regulatory framework and policies concerning nutraceuticals in the global markets, see Chopra’s et al. (162) review
Nutraceuticals require a sharp classification and shared regulation to protect the category
Clinical trials are crucial for understanding the dosage
and side effects of nutraceuticals in managing osteoporosis
we conducted a literature research through the PubMed database
with the CLINICAL TRIAL filter and the keywords “type/name of the nutraceutical,” “osteopenia,” “osteoporosis,” “bone loss,” and “bone fragility.” We considered papers published from 2000 until today and written in English
We excluded one paper written in Chinese and one in Russian
We also evaluated previous reviews on this topic
A study evaluating Ca supplementation’s long-term effects (5 years) revealed that the bone benefits did not persist once supplements were stopped (181). Men with primary osteoporosis administered vitamin D or Ca supplements reported transient beneficial effects (182)
Those studies highlight the need for further research on the long-term effects of nutraceuticals
which could significantly impact osteoporosis management
Measuring the effects of nutraceuticals on bone health has been challenging, leading various clinical trials to utilize the 41Ca methodology. The reason for choosing this approach was that traditional analytical methods were often unable to detect the small effects of those compounds on bone (166, 183)
The side effect issue still needs to be addressed
Some of the reported publications did not indicate any side effects
but it is unclear if they were not evaluated or if there were none
We have utilized the “strengths, weaknesses, opportunities, threats (SWOT)” analysis to identify and discuss the advantages and disadvantages of nutraceuticals in preventing bone loss and osteoporosis, consider internal and external variables, and define goals to achieve and future directions (Figure 2)
Strengths are internal factors that can be exploited
whereas weaknesses are internal limitations that must be addressed
Opportunities are external possibilities that can be capitalized on
while threats are external issues that need to be evaluated and faced
SWOT analysis showing the critical aspects of nutraceuticals for preventing bone loss and osteoporosis
Nutraceuticals exist in various forms, such as tablets, capsules, liquids, and powders, which make them easy to consume. They have few side effects (202), becoming promising for prevention. They can also be combined with other nutraceuticals, supplements, or drugs to improve or enhance their therapeutic effects or absorption (54, 203)
The global nutraceuticals market is constantly increasing
and academia and sector companies are allocating more resources to Research & Development
The diversity of nutraceuticals allows for a wide distribution range
Consumers are more aware of the potential of natural-based alternatives and personalized nutrition that they prefer over synthetic pharmaceutics
The regulation of nutraceuticals varies across different countries and is not consistent worldwide. Differently from drugs, nutraceuticals are subject to less strict production requirements, which can lead to a lack of safety and effectiveness data (206)
There is no proper knowledge about the dosage and intake regimen to avoid inappropriate use or overuse, which can lead to toxic effects and health complications (202, 207)
Natural ingredients that are beneficial to health cannot be patented
synthetic food supplements such as vitamins
and antioxidants pose significant competition
nutraceuticals can help prevent osteoporosis and promote overall well-being in individual with increased risk for severe illness
This potential warrants further research and exploration in nutrition and osteoporosis management
Our intent to stay abreast of ongoing investigations led us to the ClinicalTrials.gov website (February 2nd, 2024) with the RECRUITING filter. Our search, using keywords such as nutraceutical name (in the field: other terms), bone loss, bone fragility, osteopenia, and osteoporosis (in the field: condition/disease), revealed that while some efforts are underway, there is still a significant gap to bridge (Table 2)
The need for more comprehensive and evidence-based data on their mechanisms of action
and interactions with other compounds is paramount
Defining the safety profile is crucial since nutraceuticals are not subject to reporting adverse reactions to competent bodies
FG: Writing – review & editing
GD: Writing – review & editing
LG: Writing – review & editing
The author(s) declare that no financial support was received for the research
The authors thank Patrizia Rappini for her assistance in preparing the manuscript
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest
The author(s) declared that they were an editorial board member of Frontiers
This had no impact on the peer review process and the final decision
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations
Any product that may be evaluated in this article
or claim that may be made by its manufacturer
is not guaranteed or endorsed by the publisher
The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fnut.2024.1445955/full#supplementary-material
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Received: 08 June 2024; Accepted: 03 September 2024; Published: 02 October 2024
Copyright © 2024 Roseti, Borciani, Grassi, Desando, Gambari and Grigolo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
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*Correspondence: Giorgia Borciani, Z2lvcmdpYS5ib3JjaWFuaUBpb3IuaXQ=
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Chris Rossetti is in his third season as the Giants' director of pro scouting.
Prior to assuming his present position, Rossetti spent seven seasons with the Miami Dolphins, the first two (2015-16) working with Giants' senior vice president and general manager Joe Schoen.
In this role, Rossetti works closely with Schoen, assistant general manager Brandon Brown, and director of player personnel Tim McDonnell to continually upgrade the roster through free agent acquisitions, trades, waiver claims and practice squad signings. He aids coach Brian Daboll and the coaching staff for each game's opponents by creating advance scouting reports during the season.
Rossetti is responsible for overseeing the team's pro scouting efforts, which include player evaluations, managing depth charts, organizing tryouts and monitoring transactions around the NFL as well as other professional leagues. Rossetti collaborates with both analytics and football administration to determine player value in the marketplace heading into the free agency period.
In June 2024, Rossetti was one of 39 NFL executives selected to participate in the NFL's Mid-Career Executive Leadership Program at the University of Michigan's Ross School of Business. This program was designed to equip the next generation of NFL leaders with highly interactive action-based learning experiences to prepare participants with the necessary tools to solve some of the most pertinent challenges that are redefining the sports industry currently.
In 2021, Rossetti was the Dolphins' assistant director of pro scouting. In that role, he evaluated players throughout the NFL as it pertained to free agency, preseason, team advances, trades, practice squads and the waiver wire. Rossetti also evaluated other professional leagues & worked alongside the analytics department to produce an advance scouting report to prep the coaching staff for upcoming games.
Rossetti joined the Dolphins as a pro personnel assistant in 2015 and spent five seasons (2016-20) as a pro scout for the team.
Prior to Miami, Rossetti spent three seasons (2012-14) in the CFL with the Toronto Argonauts' player personnel department. He initially began as a scouting assistant in 2012 where he was a member of the 100th Grey Cup championship team. He was then promoted to player personnel assistant the following year before serving as the director of player personnel in 2014 at the age of 24.
Rossetti is a Mississauga, Ontario (Canada) native. He was a two-year starter as a quarterback at the University of Guelph (Ontario), graduating in 2012 with an honors degree in history. He and his wife, Alex, have two daughters, Hailey and Sophia.
Text description provided by the architects. The “Villa Ortuzar” neighborhood in the city of Buenos Aires is characterized as a low-scale residential neighborhood with many trees.
© Javier Agustín RojasThere is a playful relationship between the floors; with different mechanisms used with the terraces, balconies, and half-coverings, the spatial understanding of the building as a whole is never lost. The user always has a visual reference of the rest of the floors, thus achieving a more active type of living: the architecture does not take a back seat, but involves and challenges the user to interact with it.
which intertwines family and neighborhood dynamics without taking away the identity of the city
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Centred on the realisation that time may not be linear
the poet explores what we now call deja vu
Sudden Light by Dante Gabriel Rossetti
We’ve previously visited Rossetti’s sonnet sequence The House of Life on Poem of the week but this time the poem is more thoroughly lyrical in style
was in fact subtitled Song IV when the revised version was collected in the 1870 edition of Rossetti’s Poems
It was the third stanza that Rossetti changed: here for comparison is the earlier version:
“Has this been thus before?” In echoing the first lines of the earlier stanzas
Omitting the heavy and harsh sounds of “-ake” and “-ain” (“shake” “wake”
although there is still a trio of internal rhymes – “despite”
The loss of the dreamy eroticism of the second line helps the reader to focus a little more on the metaphysics
The syntax of the whole stanza is subtle and cohesive
Sudden Light is centred on the realisation that time may not be
Rossetti’s thought is more complex than the romantic ideal of love’s continuation by the importation of souls into the afterlife
although love beyond the grave is a theme here
The first stanza judges the amount of detail exactly in its impressionistic description of the place where the first moment of illumination occured
Stanza two shifts to the direct address (“You have been mine before …”) and reveals itself as a love song
The mysterious dawn of familiarity on this occasion is captured in the way the lover’s neck has “turned so”
The “swallow’s soar” seems vaguely and perhaps not altogether successfully connected to that movement
the description of the bird’s flight as “eddying” cleverly suggests the looping movement attributable to time
the metrical patterning in each stanza creates an impression of fluctuation
while the repetitions and echoes help sound the concept of circularity
recalling the metrical versatility of Elizabethan songs and madrigals
The song of the internal rhyming is particularly beautiful in the first stanza
in the lines describing “The sweet keen smell
the lights around the shore.” A subtle combination of sensory impressions – the grass-smell
the distant and distance-marking lights – swiftly arouses the reader’s imagination
and plainly related but intense experiences
The moments where perception is heightened by the “sudden light” of recurrence are familiar to almost everyone
It’s perhaps more commonly known as deja vu
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The entwined lives and relationships of William and Jane Morris
which were relatively common in the Victorian age
Eight years after the wedding and the birth of two children
Jane began an affair with Dante Gabriel Rossetti
William’s friend and business partner – with the agreement
Those known to the couple as well as posterity have struggled to explain it
The standard view is that ‘Janey the Beautiful’ was simply overcome by the passionate
But clearly it was Jane’s decision to spend summers with Rossetti and winters in London with her husband and daughters
And to ensure this was deftly accomplished
Suzanne Fagence Cooper has previously chronicled the comparably adept manner in which Effie Gray extricated herself from an unhappy
unconsummated marriage to John Ruskin in order to become the wife and artistic partner of John Millais
she traces the Morrises’ shared and separate lives with the same clarity and judicious assessment
when the Pre-Raphaelites were painting a series of murals in the library of the Oxford Union debating society
young Jane and William began married life by designing and decorating their own newly built Red House at Bexleyheath in Kent
which remains remarkably untouched – although now set amid suburbs
Jane came from the servant ranks; henceforth she managed the household
She learnt to play music and read French and Italian and taught her daughters in turn
The couple were both involved in the firm that became Morris & Co.
decorating church and domestic interiors (yes
her sister Bessie and other women stitched richly patterned altarcloths; soon Jane managed the embroidery commissions
Convivial business meetings were held in the Morrises’ next home in central London and the family holidayed with the Burne-Joneses and Faulkners
Jane has a comparably terrible reputation as a silent
Cooper leads us through the couple’s experiences
She imagines them in various locations but does not seek to invent their thoughts
Some known details are omitted – Jane’s unfulfilled wish for a son
her clandestine correspondence with Rossetti
Notably the evolution of William’s aesthetic taste from quaint medieval to proto-modern plainness
plus the analytical account of the tiny ornamented booklets that Jane created – when and for whom were they designed
No letters from Jane to William or his family survive
so we don’t know what she called him at home
he was ‘Topsy’ or ‘Top’; outside it was always ‘Mr Morris’
biography like this is not ‘history from below’ so much as what Phyllis Rose called ‘higher gossip’
It draws readers along engaging narratives to which we can relate
whose achievements are so various in poetry
also wrote of his ‘disappointments and tacenda’ – things best left unsaid
Jane grieved acutely and had her own ‘unspoken’ list
including her childhood and the destroyed or hidden love letters from Rossetti
For the months they spent at Kelmscott Manor near Lechlade
The Manor has reopened this year after a refurbishment
who loved the house and walled garden excessively
One strength of Cooper’s storytelling is its attention to how Jane and William created each of their homes
with comfort and fine objects but without superfluity
there was nothing that was not either beautiful or useful
When Rossetti’s conflicted shame in ‘stealing’ his friend’s wife drove him to a paranoid breakdown
William allowed him to convalesce at Kelmscott until Jane acknowledged she could not mend his mind
Nothing records William reproaching Jane or gloating over this outcome
All observers noted the quiet affection between the couple
There have been many books about William Morris and will be many more
but How We Might Live paints a genial picture of entwined and
Jan Marsh is the former president of the William Morris Society
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2023 at 6:07 AM ESTBookmarkSaveLock This article is for subscribers only.Romania’s central bank said climate change presents a risk to the Black Sea nation’s financial stability
with a top official citing the “significant negative implications” for the real economy
In a historic first, the National Bank of Romania spelled out the climate risk in its latest financial stability report
showing that more frequent droughts and extreme weather have a direct impact on half the economy
Companies at risk generate some 40% of value added to Romania’s $284 billion economy and hold 48% of total assets
A group of children from Mississippi are visiting the Berean Bible Fellowship Church in Stroud Township this week to experience a new way of life and form bonds with church members
The local church last year went on a mission trip to a church in Noxubee County
said John Roseti of Berean Bible Fellowship Church
Roseti added that the community in Mississippi is generally low income
"We wanted to show them that there are opportunities out there for them
and so we're bringing them up here so they can see a different way of life," he said
Members of the church raised money and volunteered to host children in their homes and provide meals for their activities
Roseti said the church planned activities around things the children have never done before
One of the trips will include a day at Knoebels for kids who have never been to an amusement park
wants to learn how to swim during a trip to Promised Land State Park
McNeese was chosen by his pastor to attend the trip for his leadership abilities and dedication to the church
"It was an honor to be chosen," said McNeese
the group hopes to build meaningful relationships that will last a lifetime
this is the first time most of these kids are on the East Coast and away from home," Johnson said
"These kids get to experience new things from a cultural and personal standpoint."
hopes they can establish opportunities for the younger people visiting from Mississippi
"We want this to be motivation to work hard
and to get past the economic barriers and show them that there are a lot of opportunities out there for them," Tomlinson said
and see there is more out there," Johnson said
The Pocono Mountains are more peaceful and bigger
She said she likes it here and hopes to come back
"I don't want this to just be something we say
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Alcova Miami's Uncharted presents a convergence of six visionary artists and designers in contemporary design through functional art
by STIRpadPublished on : Nov 30
“In response to this collective longing for something new
six artists have joined forces to present their work in Uncharted
Each artist has embarked on a personal journey into unmapped realms and returned with unique mementoes
presented together in an atmosphere of the otherworldly,” states the exhibition's curatorial note
Studio Sam Klemick is a Los Angeles-based design studio driven by imagination and guided by circular methods. The studio is committed to utilising salvaged materials and deadstock/ vintage textiles. As a fashion designer
Klemick conceived her studio after observing the wasteful
‘fast’ practices within the industry
and the objects in this show represent the artefacts we are each bringing back after a process of discovery
It’s about inspiring a sense of wonder and curiosity
challenging viewers to think about the future
but also to take a closer look at what’s already right in front of them,” relays Klemick
“Presenting anything speculative causes people to take a moment
It pulls you out of your everyday reality and the spaces you’re used to confronting
we want to offer a moment of pause and deep presence
and hope our objects can conjure that in whatever space they find themselves in.”
Volume 9 - 2022 | https://doi.org/10.3389/fmed.2022.997876
This article is part of the Research TopicImpact and Consequences of COVID-19 on the Musculoskeletal SystemView all 7 articles
Joint pain and arthralgia can be manifestations of COVID-19
and studies evaluating long COVID symptoms identified the persistence of these disorders
some case reports highlighted the development of new inflammatory arthritis in patients with COVID-19
Viral infections and rheumatic diseases share a documented relationship; they have been associated with genetic and environmental risk factors responsible for some of them
There is crosstalk between viruses and the immune system during the development of several rheumatic diseases
infections may participate in the pathogenesis of autoimmune rheumatic diseases and contribute to patient mortality
it is crucial to provide a clearer insight into the interaction between viral infections and rheumatic diseases
we provide a mini-review of the current literature with the aim of shedding light on the relationship between COVID-19 and rheumatic or musculoskeletal diseases
we examined several aspects: risk for the rheumatic population of acquiring the virus or developing severe symptoms
the possible rheumatic consequence of COVID-19
and COVID-19 prevention in rheumatic patients through vaccination
Viral infections and RD share many features. A few viruses have been associated with genetic and environmental risk factors for some RD. There is crosstalk between viruses and the immune system during developing several RD. Moreover, infections may participate in the pathogenesis of autoimmune RD and contribute to patient mortality. Therefore, it is crucial to provide a clearer insight into the interaction between viral infections and rheumatic disorders (11)
we provide a mini-review of the current literature to shed light on the relationship between COVID-19 and rheumatic or musculoskeletal diseases
after a brief presentation of COVID-19 and RD
We performed a comprehensive search according to the review strategies recommended by Gasparyan et al. (12)
We conducted the search through LitCovid/Pub-Med
and non-peer-reviewed sources were not included
Schematic representation of COVID-19 immune patterns
SARS-CoV-2 enters the host's cells through the ACE-2 specific receptor and triggering several patterns
Clockwise from the left they are: T cell activation through a high expression of CD69
CD8-T and B-cells; lymphocyte dysfunction including NK and T-cells; monocytes and granulocyte abnormalities (increased neutrophil levels
increased amount of antibodies and cytokines
the risk factors for COVID-19 infection or developing severe illness in the general population may also apply to patients with rheumatic disease
Like many other viral infections, SARS-CoV-2 can potentially lead to rheumatological and autoimmune manifestations such as arthralgia, myalgia, proximal weakness, disabling fatigue, musculoskeletal pain, cognitive difficulties, and mood. The immune consequences of SARS-CoV-2 infection and the environment should explain the rheumatic musculoskeletal manifestations of COVID-19 (43)
Many patients with rheumatic and musculoskeletal diseases continue to have persistent and/or increased symptoms, especially fatigue, and dyspnea. It is important understanding the potential pathways and manifestations leading to rheumatic illnesses that could be triggered due to COVID-19. In a prospective study, Di Iorio et al. (44) describe a sequela of worse events after COVID-19 in patients with systemic autoimmune RD
possibly related to underlying condition leading to altered immunity
no anti-viral or anti-inflammatory treatments are effective for SARS-CoV-2 infection since several studies have shown contradictory results
due to the high number of infected people and the high SARS-CoV-2 infectivity and/or lethality
most therapeutic decisions have been made based on experience instead of evidence
Rheumatic patients, particularly with immune-mediated inflammatory disease ones (IMID), are a priority target group for the COVID-19 vaccine campaign (58)
In these patients vaccination induces an immunological response that is higlighted below
Current evidence supports a non-significant flare-up in Rheumatic patients after COVID-19 vaccination. However, the risk of rheumatic disease flare or worsening does exist, especially in patients with high disease activity. COVID-19 vaccine may induce autoimmunity by similar SARS-CoV-2 infection mechanisms such as molecular mimicry, epitope spreading, bystander activation, and polyclonal activation (63)
Some studies analyzed disease activity before and after vaccination and found no significant changes in the overall disease activity
This mini-review aims to elucidate the relationship between COVID-19 and rheumatic or musculoskeletal diseases by highlighting several aspects: risk for the rheumatic population of acquiring the virus or developing severe symptoms
Optimizing the care of people with rheumatic pathologies during the COVID-19 pandemic is crucial
up-to-date analysis of the relationship between COVID-19 and RD
we found that many concepts are still unclear
several definitive support data are still lacking
international studies are necessary to investigate the mechanisms underlying the virus's interaction with the immune system
particularly regarding the potential association between SARS-CoV-2 infection and systemic autoimmune diseases
The limit of this mini review is that it is narrative
A systematic review starting from a formulated question would make it possible to extract and analyze data based on evidence and obtain a more comprehensive report
The advantage of a narrative review is the ability to discuss data
We intended to provide the readers with a critical point of view on the crucial topic of managing rheumatic patients in the time of COVID-19
Conceptualization and writing review and editing: BG and LR
Methodology and writing original draft preparation: LR
All authors have read and agreed to the published version of the manuscript
We would like to thank Patrizia Rappini for her assistance in preparing the manuscript
Reactive arthritis after COVID-19: a case-based review
PubMed Abstract | CrossRef Full Text | Google Scholar
A novel coronavirus from patients with pneumonia in China
COVID-19: unmasking emerging SARS-CoV-2 variants
COVID-19 in people with rheumatic diseases: risks
Novel coronavirus disease-2019 (COVID-19) in people with rheumatic disease: epidemiology and outcomes
EULAR provisional recommendations for the management of rheumatic and musculoskeletal diseases in the context of SARS-CoV-2
American college of rheumatology guidance for the management of rheumatic disease in adult patients during the COVID-19 pandemic: version 3
Management of autoimmune disease during the COVID-19 pandemic
PubMed Abstract | CrossRef Full Text | Google Scholar
Update alert 6: masks for prevention of respiratory virus infections
Of bugs and joints: the relationship between infection and joints
Writing a narrative biomedical review: considerations for authors
The complexity of SARS-CoV-2 infection and the COVID-19 pandemic
SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically proven protease inhibitor
Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2
The pathogenesis and treatment of the ‘cytokine storm’ in COVID-19
The SARS-CoV-2 as an instrumental trigger of autoimmunity
COVID-19: immunopathogenesis and Immunotherapeutics
PubMed Abstract | CrossRef Full Text
A Proposed framework and timeline of the spectrum of disease due to SARS-CoV-2 infection: illness beyond acute infection and public health implications
PubMed Abstract | CrossRef Full Text | Google Scholar
CrossRef Full Text | Google Scholar
PubMed Abstract | CrossRef Full Text | Google Scholar
Inflammatory arthritis in patients with COVID-19
“The spectrum of rheumatic diseases” In: Atzeni F
The Handbook of Systemic Autoimmune Diseases
CrossRef Full Text | Google Scholar
Osteoarthritis: a disease of the joint as an organ
Management of rheumatoid arthritis: an overview
PubMed Abstract | CrossRef Full Text | Google Scholar
Reactive arthritis before and after the onset of the COVID-19 pandemic
COVID GEAS: COVID-19 national survey in patients with systemic autoimmune diseases
Incidence of COVID-19 in patients with rheumatic diseases treated with targeted immunosuppressive drugs: what can we learn from observational data
Factors associated with COVID-19-related death in people with rheumatic diseases: results from the COVID-19 global rheumatology alliance physician-reported registry
Management of osteoarthritis during the COVID-19 pandemic
COVID-19 in joint ageing and osteoarthritis: current status and perspectives
COVID-19 and rheumatoid arthritis crosstalk: emerging association
The WHO Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group
Association between administration of IL-6 antagonists and mortality among patients hospitalized for COVID-19: a meta-analysis
PubMed Abstract | CrossRef Full Text | Google Scholar
IRF1 is critical for the TNF-driven interferon response in rheumatoid fibroblast-like synoviocytes
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes
Antirheumatic disease therapies for the treatment of COVID-19: a systematic review and meta-analysis
chronic inflammatory rheumatic disease and anti-rheumatic treatments
Autoimmune and rheumatic musculoskeletal diseases as a consequence of SARS-CoV-2 infection and its treatment
and prolonged symptom duration after acute COVID-19 among participants with rheumatic disease: a prospective study
COVID-19 and the clinical course of rheumatic manifestations
COVID-19 revisiting inflammatory pathways of arthritis
and outcomes of COVID-19 in autoimmune inflammatory joint diseases and autoinflammatory disorders
SARS-CoV2-triggered acute arthritis: viral arthritis rather than reactive arthritis
Transient monoarthritis and psoriatic skin lesions following COVID-19
Axial presentation of reactive arthritis secondary to Covid-19 infection
PubMed Abstract | CrossRef Full Text | Google Scholar
Case series of acute arthritis during COVID-19 admission
Multisystem inflammatory syndrome in children (MIS-C) associated with SARS-CoV-2: a systematic review
PubMed Abstract | CrossRef Full Text
cubital or tarsal tunnel syndrome after SARS-CoV-2 infection: a causal link
Antimalarial myopathy: an underdiagnosed complication
prospective longitudinal study of 119 patients
Lopinavir/ritonavir in the treatment of HIV-1 infection: a review
PubMed Abstract | CrossRef Full Text | Google Scholar
A pharmacological profile of ribavirin and monitoring of its plasma concentration in chronic hepatitis C infection
Type I interferon–mediated autoimmune diseases: pathogenesis
Humoral and cellular responses to spike of δ SARS-CoV-2 variant in vaccinated patients with immune-mediated inflammatory diseases
A practical approach for vaccinations including COVID-19 in autoimmune/autoinflammatory rheumatic diseases: a non-systematic review
Chemically modified mRNA beyond COVID-19: potential preventive and therapeutic applications for targeting chronic diseases
Incidence and prevalence of vaccine preventable infections in adult patients with auto-immune inflammatory rheumatic diseases (AIIRD): a systemic literature review informing the 2019 update of the EULAR recommendations for vaccination in adult patients with AIIRD
Humoral and cellular response to COVID-19 vaccination in patients with autoimmune inflammatory rheumatic diseases under real-life conditions
The flare of rheumatic disease after SARS-CoV-2 vaccination: a review
Reactive arthritis after COVID- 19 vaccination
Arthritis following COVID-19 vaccination: report of two cases
PubMed Abstract | CrossRef Full Text | Google Scholar
SARS-CoV-2-Vaccine-Inactivated-Sinovac-Biotech
CrossRef Full Text | Google Scholar
Arthritis of the left elbow joint after vaccination against SARS-CoV-2 infection
PubMed Abstract | CrossRef Full Text | Google Scholar
Seropositive rheumatoid arthritis after vaccination against SARSCoV-2 infection
and safety of COVID-19 vaccines in rheumatic patients: an updated systematic review and meta-analysis
American college of rheumatology guidance for COVID-19 vaccination in patients with rheumatic and musculoskeletal diseases: version 3
Disease flare and reactogenicity in patients with rheumatic and musculoskeletal diseases following two-dose SARS-CoV-2 messenger RNA vaccination
Citation: Roseti L and Grigolo B (2022) COVID-19 and rheumatic diseases: A mini-review
Received: 19 July 2022; Accepted: 12 September 2022; Published: 26 September 2022
Copyright © 2022 Roseti and Grigolo. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY)
*Correspondence: Livia Roseti, bGl2aWEucm9zZXRpQGlvci5pdA==
Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations
Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher
94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish
Sharpay Evans or Ryan Evans to almost any pre-teen or teen
and they'll know these names even if you don't
And they're probably bubbling with excitement in anticipation of Aug
Disney's "High School Musical" made-for-TV movie has youngsters across the country singing the songs and dancing the moves of the Wildcat crowd from East High
"High School Musical 2" will air on the Disney Channel
So while these teens who made the 2006 soundtrack a chart-topping hit wait
Pocono Lively Arts will present the student production of the stage version of "High School Musical" this weekend at the Sherman Theater in Stroudsburg
hadn't seen the movie and first encountered the story while reading the stage adaptation
The PLA board expressed a keen interest in the show because of its popularity
and secured the rights before the show went on tour
"It sends a powerful message about people learning to be themselves and not feeling the pressure to be a part of a clique," Jordan said
The stage version has three new songs and several expanded numbers
and many characters are more fully developed
of East Stroudsburg has been cast in the role of diva Sharpay Evans
All my friends knew all the numbers and dance moves," said Dickison
who is a recent graduate of East Stroudsburg High School-South and will head off to Pace University to study musical theater in the fall
was a bit put off by the cover of the soundtrack
which featured the characters in a dance pose
who will enter his junior year and is homeschooled
"It's talking about breaking off limitations that people put on you as part of a group and being yourself
Don't let people pressure you into something you're not," Roseti said
meets bookworm Gabriella while singing karaoke during a skiing trip
She enrolls in his school after winter break
are stars of the drama club and excited about the auditions for the school musical
and all four are called back for a second audition
Sharpay is unhappy and schemes to have the callbacks conflict with the championship game and science decathlon
and this is an opportunity to break out," Dickison said
has never extended his reach beyond sports
and the student body is surprised by his breakout attempt
prompting the song "Stick to the Status Quo" at the end of the first act
That point is that every person has worth and should not be pigeonholed into an identity
who he feels is not fully content with basketball alone
"And I like that he has good taste in girls."
The all-student production features 29 youths and two adults
"So much of our emphasis is education through the arts
energy and enthusiasm that young people bring to a production," Jordan said
the cast has not only learned the music and dialogue
and that's the beauty of bringing young people together on the stage
who has been in other productions that were more of a mix of youths and adults
People want to be there because they're excited
When he checked the cast list release on the Web
It's just the kind of show you can't help but like."
Even theater people should take a closer look
"It's such a bubble-gum show that theater people look at it critically
but it is bringing new people to the theater
A Natick man ran from police when they tried to arrest him yesterday on a pair of warrants
but was later found at a friend's house after a search that lasted more than three hours
and evaded seven police officers and four Massachusetts State Police troopers and their search dogs
Officers went to Rossetti's residence at 2:26 p.m
to serve him a Framingham District Court warrant for a restraining order violation and a Clinton District Court warrant for assault and battery
straight road leading toward Rossetti's home
"He took off through the back door and into the woods," said Grassey
He seems intent on not being apprehended at this time."
The officers tried to set up a perimeter around the woods and use the dogs to search
but the dogs lost the scent when they hit Rte
The officers went to a Pitts Street home at 4:20 p.m
because they knew Rossetti's friend lived there
was evasive with his answers about Rossetti and told them he did not feel comfortable letting the officers in without his parents being there
who asked the police to wait until they got home before they went in
and we surrounded the house until they got home," Pagliarulo said
The unnamed teen's father went into the house after he arrived home and brought out Rossetti
He was to be held overnight at the Natick Police station until he appears in Natick District Court today
Rossetti has been arrested several times this year
he was arrested in Natick after a domestic dispute and charged with assault and battery and a restraining order violation
he was arrested in Natick on a Clinton District Court warrant that charged him with assault and battery
He was also arrested in Wayland in March and charged with a violation of a restraining order
(Norman Miller can be reached at 508-626-3823 or at nmiller@cnc.com.)
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The North Bay Bulldogs family is rallying behind one of their own who was seriously injured in a motorcycle collision on Highway 11 at Lakeshore Drive Friday morning around 3 a.m
We apologize, but this video has failed to load.Try refreshing your browser, ortap here to see other videos from our team.Play VideoArticle contentReece Rossetti
was transported to a Sudbury hospital where he remains
Rossetti sustained a broken vertebrae in his neck and back
According to his former Bulldogs football coach
he will be in surgery today for six to seven hours to repair his arms and hands
“Eventually he will be moved to Ottawa to have surgery on his knees.”
have organized a gofundme page to help the family with incurring unexpected expenses
Morgan said the funds will be used for gas or hotel stays as needed
as well anything Rossetti needs in his recovery
Morgan said Rossetti started playing Bulldogs football in grade 8 and then enjoyed the sport in bantam
and then helped coach youth and bantam when his work scheduled allowed
“The North Bay Bulldogs is truly a family and supports one another in times of need.”
At Sunday’s bantam and junior varsity games
donations will be collected that will go directly to the family
“The Rossetti family is a family that would do anything they could to help others
so now it’s our turn to help them,” Morgan added
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VMI Worldwide has dropped the first trailer for Piper, an upcoming supernatural thriller headlined by Elizabeth Hurley. Acquired by 101 Films after this year’s Cannes film market, the movie is poised for its global debut at FrightFest 2023 on August 27, according to The Hollywood Reporter
The film will get a general release in the United Kingdom on October 16
In Piper, Liz (Elizabeth Hurley) and her daughter Amy (Mia Jenkins) relocate to a peaceful German town
only to face a local girl’s mysterious death and a string of chilling events
These occurrences are connected to a sinister secret from Liz’s past
awakening the malevolent Piper who threatens Amy due to the sins of her parents
Amy’s encounter with the mysterious Luca might hold the key to her salvation from the Piper
but there’s no information on a release in the United States
Along with Elizabeth Hurley and Mia Jenkins
the cast of Piper is comprised of Jack Stewart (Float)
Jurijs Djakonovs (Crime Solving for Beginners) and Elizabete Liepa (Christmas in the Jungle)
Evija Koltone and Dominik Gabriel Roseti join the cast as newcomers. Anthony Waller (The Guilty) directed the film from a script he co-wrote with Duncan Kennedy (Deep Blue Sea)
Piper may seem like a notable shift from Elizabeth Hurley’s past projects
but this isn’t her first foray into horror
she took on a role in the low-budget horror movie Beyond Bedlam (also known as Nightscare)
an early and relatively obscure work in her career
This film often goes unnoticed or remains unfamiliar to many
Elizabeth Hurley is now known for her dramas and romantic comedies
but she’s no stranger to the horror genre
a neurologist conducting trials of a supposedly harmless mind-altering drug on Marc Gilmour
As strange suicides unfold within Stephanie’s apartment complex
Detective Terry Hamilton establishes a link between these deaths and the sinister impacts of the drug on Gilmour
It’s only when both Stephanie and Terry find themselves ensnared in Gilmour’s nightmarish realm
plagued by terrifying dreams and hallucinations
that they grasp the grim truth – escape is an impossible feat
Elizabeth Hurley appeared in a string of lighter-toned projects
but she returned to the horror genre in 2002’s Method
a renowned actress selected to portray the actual 19th-century serial killer Belle Gunness in a film
she gradually adopts the character’s traits
blurring the lines between her on-screen and off-screen personas
Elizabeth Hurley may not be starring in massive Hollywood blockbusters
but she’s keeping plenty busy with independent films and running her own fashion company
Fans who have enjoyed Elizabeth Hurley’s past ventures into the horror genre can look forward to a gratifying addition to her body of work with Piper. Despite the passage of time since her last genre endeavor, the trailer for Piper demonstrates her enduring capability to lead a horror movie effectively. Scheduled for an October 16 theatrical release, the film perfectly aligns with the Halloween season
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