Is "NORTH" The Best Surf Photography Book Ever Made? From Tubes To Turns, Jai Glindeman's Surfing is a Treat to Behold Gerry Lopez Goes Deep With Justin Jay On The Plug Podcast NewsAll NewsEventsBig Wave NewsWorld Surf LeagueEnvironmentalIndustryWave PoolsPosts List ‘He Was Such a Legend’: A Decade After His Death, Shawn “Barney” Barron’s Spirit Shines in Colorful Air Show Hawaiian Big Wave Icon Clyde Aikau Passes Away at 75 SwedenThe 2012 Winter Jam goes down in Varberg as the coldest surf comp ever LLC and respective content providers to this website may receive compensation for some links to products and services on this website there was held a surf contest in December at a secret spot in Varberg which has been unofficially dubbed Surf City Contest director Johan Otterdahl tells us more: It's a new competition for surfers who live in Sweden and refuse to realize that winter is here A chance to meet new surfers and share the stoke It's also a great opportunity to surf a new spot I surfed this spot more or less by myself for many years and I was looking forward to have someone to share the waves with It's nestled in one of the most amazing surroundings I've ever surfed in How did a town in Sweden get the “Surf City” title Varberg is a surf town (the only one of its kind in Sweden) on the Swedish west coast It got famous in the '80s for windsurfing I've been surfing here since the mid-90s In the beginning we only knew about three spots in our own town The biggest selling surf magazine in Scandinavia is Nordic Surfers Mag and Mat What kind of storm does it take to light up the Swedish coast We don't get the hurricanes like you do in the U.S. maybe some smaller ones every six years or so We need between 23- to 35-knots of onshore winds to get waves in my town and across most parts of the Swedish coastline I've only surfed one Christmas Eve in Sweden When I checked the weather report in the morning When I finally came to the spot a few hours before the comp I thought there weren´t going to be any waves But I arrived to a clean set rolling in with and empty lineup During the competition the waves were smaller We had everything from knee- to head-high waves It's very rare to get glassy waves in Sweden During the whole competition the snow was falling like crazy But it was at least warmer in the sea than on land and random folks taking a walk with the dog Probably the coldest surf comp in the history of the sport What kind of neoprene do y'all need to survive Most of the time it's a 6/5/4mm wetsuit When it's extra cold we use Vaseline in our faces to keep a bit warmer the wetsuits are amazing and the surf shops got everything covered When I started surfing here I used to double-up on wetsuits a Costa Rican with the last name Gutierrez Derek Gutierrez is a ripping Costa Rican living just a few miles from Varberg stuck here because of one thing: the Swedish girls Derek is a real cool guy who surfs whenever there is an opportunity He had to borrow a wetsuit to enter the competition we really see who is a true Swedish surfer or not He´s studying Swedish and speaks it really well; he's more of a Swedish surfer than most of the other surfers in this country Have you guys been to Hawaii in the winter My biggest dream in the whole world since I was 8 was to go to Hawaii I spent one week in Waikiki and 10 days on the North Shore in 2006 I walked over to Pipe everyday just to watch Waves I've been watching on VHS for almost 20 years 2012 Surf City Winter Jam Results:1: Derek Gutierrez2: Pontus Hallin3: Johan Otterdahl Gideon Mensah (right) plays for Swedish club VarbergBildbyran / ddp USA / ProfimediaThe life of a footballer can often feel isolating players make significant sacrifices to reach their goals.Even after achieving professional status they frequently find themselves away from family and loved ones for extended periods Imagine dedicating your life to the sport you love, only to face a sudden and prolonged absence from the pitch. This has been the reality for Gideon Mensah who has experienced the heartache of being sidelined from playing football - the very thing that fuels his passion and purpose Mensah's journey in football began in Ghana, where he honed his skills at the prestigious Right to Dream Academy. His talent quickly earned him a move to Denmark, joining Nordsjaelland However, breaking into the first team proved challenging, and after struggling for game time, he made a pivotal decision to go on loan to Swedish club Varberg in July 2020 marking a significant turning point in his career Reflecting on his early professional experiences in an exclusive interview with Flashscore Mensah shared: "My few years going professional weren't what I expected "The first year and a half in Denmark were quite difficult for me I tried to settle in with the team and earn my place in the starting lineup Transitioning from Denmark’s U19 and second teams to the first team in Sweden required significant adaptation Mensah noted the cultural differences between the two Scandinavian countries: "Even though they’re both in Scandinavia I had to adjust to the language and even the food - though thankfully His first two years at Varbergs BoIS were filled with promise as he transitioned to competing at a professional level "The first two years were incredible," he recalled "I got to play more professional games The experience there was very good for me." just as he began to find his footing and thrive on the pitch A bad tackle resulted in an ACL injury that would sideline him for an extended period "My foot got stuck in the artificial grass during a session in winter and my teammate kicked my leg while attempting to get the ball Everything that came after the click was a hell of pain." The injury not only caused physical pain but also emotional turmoil as he grappled with feelings of frustration and helplessness “I had to wait because the next day my knee was very swollen So I was hoping it was a small tear or it was a But it was swollen for almost a month and when the knees are swollen the MRI won’t work” Waiting for an MRI was agonizing; he hoped for minor damage but was met with the grim diagnosis:  “I got the result in three weeks from the doctor leading him into a dark period filled with self-doubt and anxiety about his future Recovery from an ACL injury is a gruelling process that requires immense mental strength and discipline Mensah emphasized the importance of patience during this time Mensah's path to recovery has been anything but straightforward he faced unexpected complications that necessitated a second operation months later to address lingering discomfort This setback has pushed back his anticipated return to the pitch the Right to Dream Academy graduate leaned on the support of family He acknowledged that having "good people around you" was crucial during such challenging times he remained focused on his goal: returning to the pitch stronger than ever Mensah's injury recordFlashscoreThe 24-year-old’s last competitive appearance was in November 2022 Having spent the latter part of 2024 doing individual training Mensah is looking forward to joining the team ahead of the new season which kicks off in February 2025 I also have to find a balance not to go all the way "I'm really looking forward to coming back and then seeing people smile when I play,” he added As Gideon Mensah nears the completion of his recovery, he watches as his fellow Ghanaians, Alidu Seidu and Fatawu Issahaku embark on their own rehabilitation journeys Quizzed about the increasing prevalence of ACL injuries it gets tired and maybe something can easily break I wish my countrymen well in their recovery The journey is tough but they are more than capable and have access to some of the best medical facilities so they will be fine.” Mensah’s aspirations extend beyond personal recovery; he aims to help Varberg regain their status in the top league “Things didn't go as we planned at the beginning of last year and the year before Some players also got the same injury so we lost maybe four or five key players that season so things were hard for us the plan is to get all the fit players back and get into our top level So I'm hoping that I can come back to be in the squad and help the team get back to the top flight.” The centre-back is eager to reclaim his peak form with aspirations of securing a significant transfer in the near future His sights are set high as he works tirelessly to prove himself once again ready to make an impact on the pitch and attract the attention of top clubs “I want to build that momentum again to go to the level I was before I got injured I want to play as many games as I can and move to a bigger club.” Having already represented Ghana at the U17 and U20 levels, Mensah holds close the dream of one day playing for the national team “I learned a lot with the U17 team, especially at the World Cup. The experience of playing around with a lot of good players like Ibrahim Sadiq, Mohammed Kudus The U20 was another experience because I improved as a player always an honour to represent your country so it will be a good feeling to play for the Black Stars it will be a good feeling because I know how it felt when I played for the youth national teams." The Våga Water Tower in Varberg is a monument to civil engineering a functional concrete sculpture that's designed to last for centuries A dramatic and sculptural wave-shaped water tower that rises above the Swedish city of Varberg is White Arkitekter’s latest project in Våga and memorials that have been bestowed monument status by their monolithic solidity the Våga Water Tower – Vattentornet Våga – is intended to have a long life ’Our ambition has been to design an object that will stand for hundreds of years never diminishing in beauty,’ says White Arkitekter’s Agnes Orstadius Intended to increase capacity for this fast-expanding city the project began with a design competition in 2017 White Arkitekter’s winning response eschews the usual solitary tower form in favour of a 187m-long structure that marches across the landscape on nine slender pillars The brief called for a functional structure that was also a ‘new landmark symbolising the power and sanctity of water as well as its profound significance to the city.’ with each concave concrete segment forming a wave shape that makes the entire structure ripple across the landscape Set atop the small hill of Bastekullen in Träslöv the new tower contains five times as much water as the old one Built by Scandinavian construction company Veidekke the tower can be accessed from a stair and elevator embedded in the large central pillar ‘Våga makes a powerful impression at a distance but the tower will also be experienced up close,’ says Orstadius and the concrete pillars have been carefully integrated into the existing landscape New wildflowers have been planted and the service road turned back into a gravel path ‘All these elements – the elongated shape and the interplay of light and shadow – mean the tower is perceived differently depending on your vantage point and the time of day,’ says Per Hultcrantz who worked as the lead architect on the project after Mattias Lind ‘This creates a dynamic quality that ensures the tower never ceases to surprise,’ he concludes The landscaping also encourages visitors to come to the base of the structure wanted the new tower to be both landmark and recreation space as well as a long-lasting piece of community infrastructure escapism and design stories from around the world direct to your inbox White Arkitekter Jonathan Bell has written for Wallpaper* magazine since 1999 covering everything from architecture and transport design to books He is now the magazine’s Transport and Technology Editor He is also the host of Wallpaper’s first podcast 01-07-2025DESIGN The country is swapping out aging water infrastructure with towers that look like sculptures [Photo: Joacim Winqvist/courtesy White Arkitekter] BY Nate Berg The Swedish city of Varberg found out the hard way that it needed a new water tower. The local water system sprang a leak and the city had to tap into its backup water supply about 525,000 gallons stored in a utilitarian UFO-shaped concrete water tower near the center of town was not enough to meet the demands of a city that has seen its population nearly triple to 35,000 over the past 60 years The water company eventually fixed its leak but the city knew it needed a better vessel for water security That’s how Varberg, a coastal city south of Gothenburg, built what may be the world’s most stunning water tower Cast in stark concrete and perched atop a small hill the water tower has the unusual form of a long and narrow rectangle propped up on nine slender pillars Scalloped along its lengths with subtle curves that recall waves of the nearby coast the water tower is a radical departure from the bulbous and cylindrical tanks found in cities around the world Designed by the Scandinavian architecture firm White Arkitekter the tower for Varberg has reinvented the water tower typology in the face of new demands and through new technology The tower has been operational since late 2024 shortly after the city’s water system malfunctioned The city and the water utility had calculated that the existing water tower had a capacity far below the city’s need so they commissioned the construction of a new facility with five times the volume “They also saw the potential of the site they chose for creating a landmark structure could really signal the town’s position,” says White Arkitekter’s Per Hultcrantz “They could have just went with a regular water tower but they decided to create an architectural competition.” The competition’s design brief called for much more than a simple utilitarian structure Hultcrantz says the stipulations included the expected water capacity and safety considerations but also that the new tower should become a landmark Hydrology and water pressure dictate many of the parameters of a water tower’s design, which is why many (but not all) appear to be lollipops large bulbs of steel or concrete stacked on a spindle Hultcrantz says the proposed site of Varberg’s new tower and its required capacity and pressure meant that its tank would have to be about 26 feet in height Following a conventional water tower design approach would have resulted in what Hultcrantz calls a wide and flat puck “We didn’t really like that shape,” he says “We decided after two days of sketching that a long stretched out design was the right way to go.” that design is a functioning piece of urban infrastructure as well as a new calling card for the city Easily visible from both residential areas in town and from a major highway running alongside the city the ribbonlike spectacle stretches 615 feet long and is only 30 feet wide It also runs directly over a small gravel road that leads to a popular hiking area on a cliff overlooking the sea Hultcrantz says the design of the tower was slightly rotated to maintain that view and its public access “It’s a nice thought that you can combine this important civic function with the also equally important recreational function,” he says The tower in Varberg is also proof that water tower typology can continue to evolve Hultcrantz says Sweden’s water tower history dates back to the late 1800s when the first water storage facilities were built out of brick and stone like oversize barrels or the turrets of ancient castles These stood for more than 150 years before upgrades were needed Postwar population growth in the 1950s and ’60s led to increased demand for backup water supplies across Sweden and the increasing availability of materials like steel and concrete spurred new structural forms “A lot of Swedish water towers are from the ’60s and they all look kind of like UFOs or mushrooms,” Hultcrantz says Population growth is again leading cities across Sweden “I think we’re in the third water tower boom right now,” Hultcrantz says Hultcrantz says other cities are launching their own design competitions for new water towers may be one of a variety of new shapes to define the water towers of the future “The whole water tower know-how is being rebuilt from the foundation again,” Hultcrantz says The final deadline for Fast Company’s Brands That Matter Awards is Friday, May 30, at 11:59 p.m. PT. Apply today. Fast Company & Inc © 2025 Mansueto Ventures Fastcompany.com adheres to NewsGuard’s nine standards of credibility and transparency. Learn More The truck charging provider Milence has opened its fourth charging hub in Europe Sweden – the first of a total of ten charging hubs that Milence is currently building in the country The new charging hub in Varberg is located on the TEN-T Scandinavia-Mediterranean corridor between Gothenburg and Malmö in southwest Sweden the “location serves as an important stop-off point for hauliers and heavy-duty vehicle drivers travelling along the main logistics routes in Sweden.” So far, Milence has only opened the first phase of the charging hub. It features four 400-kW chargers with two charging points each. For the second phase, “set to launch in 2025,” the charge point operator will add more CCS and MCS chargers. Milence successfully tested MCS for the first time in July Milence wants to significantly increase charging capacity and enable heavy commercial vehicles to be charged even faster and more reliably Customers can pay using one of the many charging cards as the CPO “has signed agreements with various e-Mobility Service Providers (eMSPs) in Europe.” Milence emphasises that direct or ad hoc payments using a credit card or the Milence app will also be possible The default charging tariff is roughly 40 cents per kWh (excluding VAT) “Sweden is one of the leading countries in Europe when it comes to sustainability and energy transition where electric road transport is a reality today With ten charging hubs under development and three to open by the end of the year this is one of our key markets and fleet operators can now start using the Milence network,” says Milence CEO Anja van Niersen “This is possible thanks to the support we receive from all the relevant stakeholders in the market and we are happy that our hub openings are becoming a platform for exchange and cooperation” The other two charging hubs planned for Sweden this year will open in Åstorp and Ödeshög A few weeks after inaugurating the first location in Varberg, Milence has opened two more truck charging hubs in Sweden. One of the new stations is located in Landvetter near Gothenburg Airport, and the other is in Ödeshög on the E4 motorway to Stockholm there are eight CCS charging points with up to 400 kW; in Landvetter The two hubs are “strategically located along the Scandinavian Mediterranean TEN – T corridor connecting Sweden to the South of Europe,” says Milence With three hubs already open and a fourth due to open in early 2025 Sweden is a leading market for the Milence network milence.com, milence.com (update) I agree with the Privacy policy electrive has been following the development of electric mobility with journalistic passion and expertise since 2013. As the industry's leading trade media, we offer comprehensive coverage of the highest quality — as a central platform for the rapid development of this technology. With news, background information, driving reports, interviews, videos and advertising messages. 13 Apr 2025 13:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}IK Brage vs Varbergs BoIS FC on Sun Predicted lineups are available for the match a few days in advance while the actual lineup will be available about an hour ahead of the match The current head to head record for the teams are IK Brage 4 win(s) IK Brage have won the previous 2 matches against Varbergs BoIS FC Have scored 7 goals in their last 5 matches Haven't kept a clean sheet in 6 matches Who won between IK Brage and Varbergs BoIS FC on Sun 13 Apr 2025 13:00:00 GMT?IK Brage vs Varbergs BoIS FC on Sun 13 Apr 2025 13:00:00 GMT ended in a 1–1 tie.InsightsHave scored 3 goals in their last 5 matches IK Brage is playing home against Varbergs BoIS FC on Sun The Våga Water Tower stands on Bastekullen, situated just outside central Varberg on the Swedish west coast. Conceived by White Arkiteker, one of Scandinavia’s pioneering architectural practices, the water tower has emerged as a new landmark in the locality symbolising Varberg’s deep connection to the sea Its distinct silhouette blending rigid linearity with wave-like curves sets it apart in the homogeneity characteristic of its typology “Våga holds a prominent place in the landscape but the tower is also designed to be appreciated up close Our ambition was to create a structure that will stand for centuries—and always remain beautiful,” says Agnes Orstadius the population of Varberg has surged by approximately 30 per cent; the water demands in the city have risen significantly as a consequence of this growth expressed the need for a larger and modern water tower Three architecture firms were invited to submit a proposal for the project: a concrete construction on Bastekullen in Träslöv capable of holding 10,000 cubic metres of water The new tower was envisioned to be a landmark emblematic of the significance of water both for the city and the world A jury including representatives from Vivab and Varberg Municipal selected White Arkitekter’s Våga as the winner The team extends this approach in Våga The word ‘våga’ stands for ‘wave’ and ‘dare’ in Swedish; this dual meaning percolates in the design concept of the water tower Våga dares to digress from the conventional cylindrical shape of water towers to imagine an innovative prototype: a horizontal wave-like profile that nods to the coastal identity of Varberg “All these elements—the slender shape concave façade and interplay of shadows—make the tower appear entirely different depending on the time of day and viewing angle This dynamic ensures the tower never ceases to surprise,” says lead architect Per Hultcrantz The westernmost part of the site offers picturesque glimpses of the sea The positioning of the tower is such that it preserves a plateau in front of it and creates a welcoming space for visitors the architects have strived to maintain a human scale which is accentuated when one looks closely at the pillars As opposed to the standard practice of using triangular fillets to ease formwork removal the tower’s edges are adorned with concave mouldings across 1800 metres sourced from hardware stores The soft corners are gentle and speak of the attention to detail given to the project The concrete casting was done against form-plywood sheets for a smooth finish; aligned joints and segment marks along with plugged holes where formwork ties were placed affirm a clean look followed a comprehensive design programme emphasising the significance of each architectural element laid out in the initial stages of the project wildflowers are sown at the foot of the tower and the service road is transformed into a green gravel path The result is a culmination of Vivab’s vision for the project as both a landmark and a recreational space alongside White Arkiteker’s architectural expertise and innovative perspective on what a water tower can be Anushka is intrigued by the power words hold in translating seemingly mundane things into something magnificent An avid vocalist and a fitness enthusiast driven by her passion for writing and researching and guided by her formal education and training she strives to explore the space where tangible forms meet intangible emotions From vernacular knowledge to modern sustainability Qatar and others at La Biennale 2025 serve as living archives of alternative architectures STIR engages with the curators of the Togo Oman and Qatar pavilions—debuting at the Venice Architecture Biennale 2025—on representation the book presents a fictional story depicting algorithms exercising control over humans and how this affects the built environment Tipnis shares how the toolbox democratises the practice of restoration via DIY resources to repair tangible urban heritage made of common building materials Exclusive preview for subscribers. Learn More Make your fridays matter. Learn More © Copyright 2019-2025 STIR Design Private Limited Please confirm your email address and we’ll send you a link to reset your password All your bookmarks will be available across all your devices Password must be 8 characters long including one capital letter By creating an account, you acknowledge and agree to the Terms of Use and Privacy Policy by STIR Select the Conversation Category you would like to watch Please enter your details and click submit Single account access for STIRworld.com,STIRpad.com and exclusive STIRfri content Verification link sent to check your inbox or spam folder to complete sign up process by Anushka Sharma | Published on : Feb 12 OX2 and Varberg Energi have agreed in principle for Varberg Energi to procure renewable electricity from the Galene offshore wind farm located near Varberg as well as from OX2’s solar project in the vicinity The long-term goal of the agreement is for the companies to enter into a Power Purchase Agreement (PPA) for the Galene offshore wind farm as well as a PPA for one or more of OX2’s solar projects in Halland OX2 received the government’s permission for the Galene project which consists of up to 21 wind turbines with a planned production amounting to approximately 1.7 TWh The 400 MW Galene the northern part of the 1.7 GW Galatea-Galene project will be built about 21 kilometres west of Varberg and comprise up to 21 wind turbines across an area of ​​42 square kilometres.  OX2 is developing the offshore wind project together with its partner Ingka Investments the investment arm of Ingka Group OX2 plans to start construction work in 2026 to enable the wind farm to be operational in 2028 or 2029 Get in front of your target audience in one move OffshoreWIND.biz is read by thousands of offshore wind professionals daily Daily news and in-depth stories in your inbox Leveraging 20 years of experience with offshore windDecember 2023 will forever mark a milestone in our company history as we became part of the world-wide CS WIND group The acquisition goes beyond a mere change in ownership; it marks a leap into a future where our combined strengths will pave the way for optimized production […] 21 Apr 2025 11:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Varbergs BoIS FC won 4–0 over Umeå on Mon The current head to head record for the teams are Varbergs BoIS FC 2 win(s) Have scored 6 goals in their last 5 matches Who won between Varbergs BoIS FC and Umeå on Mon 21 Apr 2025 11:00:00 GMT?Varbergs BoIS FC won 4–0 over Umeå on Mon 21 Apr 2025 11:00:00 GMT.InsightsHave scored 7 goals in their last 5 matches Varbergs BoIS FC is playing home against Umeå on Mon 29 Mar 2025 16:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Falkenbergs FF vs Varbergs BoIS FC on Sat The current head to head record for the teams are Falkenbergs FF 10 win(s) Who won between Falkenbergs FF and Varbergs BoIS FC on Sat 29 Mar 2025 16:00:00 GMT?Falkenbergs FF vs Varbergs BoIS FC on Sat 29 Mar 2025 16:00:00 GMT ended in a 2–2 tie.InsightsHave scored 7 goals in their last 5 matches Falkenbergs FF is playing home against Varbergs BoIS FC on Sat 07 Apr 2025 17:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Varbergs BoIS FC won 2–1 over Örebro on Mon The current head to head record for the teams are Varbergs BoIS FC 3 win(s) Haven't kept a clean sheet in 5 matches Have scored 5 goals in their last 5 matches Who won between Varbergs BoIS FC and Örebro on Mon 07 Apr 2025 17:00:00 GMT?Varbergs BoIS FC won 2–1 over Örebro on Mon 07 Apr 2025 17:00:00 GMT.InsightsHave scored 7 goals in their last 5 matches Varbergs BoIS FC is playing home against Örebro on Mon ArkeologernaThe earliest graves at the site date to around the late eighth century C.E While investigating a Stone Age settlement just outside of Varberg archaeologists serendipitously discovered a massive Viking-Age burial ground rife with artifacts just six percent of the site has been excavated but researchers have already revealed 139 graves holding both human and animal remains The initial examination of the site began back in May 2017 when the local government announced plans to build a roundabout and install new water pipes Officials wanted to ensure any Stone Age artifacts weren’t damaged by the construction — but they soon realized that there was much more beneath the surface than they expected to find ArkeologernaResearcher Anders Kjellin looks out at the nearby Tvååkersån River When archaeologists from Arkeologerna first arrived at the site near Varberg in 2017 they made some initial discoveries of flint and a furnace but it became evident within the first year that the area had more secrets waiting to be uncovered “We had found five graves with bone remains and fire layers,” said archaeologist Petra Nordin “The bones were from dogs and humans Then we realized that here was a large Viking burial ground that we had to focus on.” what began as a fairly standard preliminary investigation of a Stone Age settlement became a years-long process of excavating a large Viking burial ground The cemetery is located on a flat ridge along the path of two important ancient trade routes: the Tvååkersån River and an old road known as Järnbäravägen much of the site has been damaged over the years due to farming ArkeologernaA gilded bird pendant recovered from a grave “The problem is that the ground has been plowed down and leveled to cultivate and create pastures so all the superstructures have disappeared and the graves have been plowed to pieces,” Nordin said “We have had to interpret everything from below because it was so torn apart But we have investigated where the bonfires are and found what we interpreted as a 50-meter-long [160-foot-long] shipwreck up on the ridge.” The research team has also discovered the impressions of three ship burials in addition to a ship-shaped mound much of the cemetery is still buried under modern construction and the team has only excavated roughly six percent of the total site ArkeologernaA Viking-Age buckle found at the site depicting a horse biting its own tail Human remains were found in oblong fire pits but some of the burials also held the bones of dogs in round pits “The dog was a companion and accompanied the human on the pyre.” One of the most fascinating discoveries so far was a square burial with three large fire pits that held 17 vessels and iron arrowheads that experts believe was a cremation site Researchers have also found bones from birds suggesting the animals were placed on graves as funerary sacrifices “Looking for bones and finding pits where the raised stones may have stood or bottoms of mounds where superstructure is missing but incredibly difficult,” said archaeologist Anders Kjellin “Sometimes we have gone with a metal detector and found objects in a place that allow us to say that this is probably actually a grave.” ArkeologernaA fragment of pottery dating back to the Viking Age archaeologists believe there was once a substantial Viking-Age settlement in the vicinity but the nature of the excavation has made it difficult to paint a clear picture of the site’s history that there may have been a Viking-era trading post at Gamla Köpstad south of Varberg,” said Nordin Is the village at the mouth of Tvååker or is it near the burial ground But it is exciting to see what will emerge in the future.” After reading about the discovery of this massive Viking burial site, learn all about Viking berserkers and why they were some of history’s most feared warriors. Then, read about Leif Erikson the Viking explorer who reached North America well before Columbus HistoryNet Jeanette Varberg is one of Denmark’s leading historians with expertise on Viking warfare and Bronze Age history she has written numerous books and articles about Danish history and Viking raids recast the history of Viking battles and global expeditions with a focus on interpreting artifacts as well as written sources A curator at the National Museum of Denmark she is a driving force behind a new exhibition entitled “The Raid,” which opened in June 2021 and will run for three years Varberg’s research continues to shed light on Vikings at war I wrote the book I missed about the Vikings I wrote an overview of their travels—both raids and adventures across the North Atlantic and to all parts of the known and unknown world I wanted to give them a solid front seat in the grand history of early medieval Europe Another misconception is that all Scandinavians were warriors they were hardworking farmers always on the lookout for new lands to put under their plows the Vikings also had no reservations about hiring themselves out as mercenaries and were not shy about changing sides if the other paid better’ In the eyes of the Christian commanders who opposed them and they were certainly guided by a very different code of honor than the Christians The Vikings had no qualms about attacking during the holidays when Christians normally abstained from warfare and engaged in celebrations But toward the end of the Viking Age the Scandinavian kingdoms themselves became Christian They then had armies that held their own against the powers of Europe—their power culminating when Danish Viking king Canute the Great ascended to the English throne That was perhaps their biggest achievement The Vikings built cities and colonies in the British Isles trading savvy and a strong belief that fortune favors the brave they left their mark throughout the known world My book tries to cover it all and keep the red thread of the Viking tale through the centuries and hopefully it will give a more nuanced understanding of the age In part of the exhibition we follow the Vikings on their biggest adventure—the voyage to the Mediterranean in 859–861 The museum experience concludes in a sea battle in an immersive room where the visiting explorer is “killed” and travels to one of the Vikings’ imagined kingdoms of the dead—the realm of Ran I want visitors to reflect on the consequences of pillaging and raiding: If you succeed This article was published in the January 2022 issue of Military History Zita is the editor of both Military History Quarterly and Vietnam Magazine She is currently pursuing a master’s degree in military history She received an award from the National Federation of Press Women in 2022 for her editing work on Vietnam Magazine She has written numerous military history books articles and book reviews and is also an award-winning author Her book “Bernard Montgomery’s Art of War” won a Silver Medal from the Military Writers Society of America She is fluent in German and is a member of the U.K Her areas of interest include the Vietnam War and World Wars I and II Whether they produced battlefield images of the dead or daguerreotype portraits of common soldiers In 1964 an Ohio woman took up the challenge that had led to Amelia Earhart’s disappearance how Wild Bill Donovan shaped the American intelligence community During the 1835–42 Second Seminole War and as Army scouts out West these warriors from the South proved formidable “History is a guide to navigation in perilous times History is who we are and why we are the way we are.” HistoryNet.com is brought to you by HistoryNet LLC, the world’s largest publisher of history magazines photo galleries and over 25,000 articles originally published in our nine magazines Subscribe to receive our weekly newsletter with top stories from master historians sign me up! The World Heritage Centre is at the forefront of the international community’s efforts to protect and preserve World Heritage partnerships for conservation Ensuring that World Heritage sites sustain their outstanding universal value is an increasingly challenging mission in today’s complex world where sites are vulnerable to the effects of uncontrolled urban development Our Partners Donate Take advantage of the search to browse through the World Heritage Centre information The Varberg Radio Station at Grimeton in southern Sweden (built 1922–24) is an exceptionally well-preserved monument to early wireless transatlantic communication including the aerial system of six 127-m high steel towers the equipment has been maintained in operating condition The 109.9-ha site comprises buildings housing the original Alexanderson transmitter short-wave transmitters with their antennae The architect Carl Åkerblad designed the main buildings in the neoclassical style and the structural engineer Henrik Kreüger was responsible for the antenna towers the tallest built structures in Sweden at that time The site is an outstanding example of the development of telecommunications and is the only surviving example of a major transmitting station based on pre-electronic technology à Grimeton dans le sud-ouest de la Suède (construite en 1922-24) est un monument des débuts de la communication transatlantique sans fil Le site comporte le matériel de transmission y compris le système d’antennes avec ses 6 pylônes de 127 m de haut Bien qu’ils ne soient plus utilisés régulièrement les équipements ont été conservés en état de marche on trouve les bâtiments qui abritent l’émetteur Alexanderson originel des transmetteurs d’ondes courtes avec leurs antennes ainsi qu’une zone résidentielle comportant les logements de fonction du personnel L’architecte Carl Åkerblad a dessiné le bâtiment principal en style néoclassique les plus hauts construits en Suède à l’époque sont l’œuvre de l’ingénieur Henrik Kreüger Le site offre une illustration exceptionnelle du développement des communications ; c’est la seule survivante des grandes stations de transmission radio fondées sur les techniques antérieures à l’ère de l’électronique تشكّل محطة فاربورغ الإذاعية في غرايمتون جنوب غرب السويد (والتي تمّ تأسيسها عام 1922-1924 وحفظها بصورة ممتازة) نصباً يرتقي الى أوائل الاتصالات اللاسلكية العابرة للأطلسي ويتضمّن هذا الموقع معدات الإرسال، بما في ذلك نظام الهوائيات المزوّد بستة أبراج للأسلاك ترتفع الى 127 متراً، وقد تمّ الحفاظ على حسن سير هذه المعدات مع أنه لا يتمّ استعمالها بانتظام وعلى امتداد 109.9 هكتارات، ترتفع المباني التي تحوي جهاز ارسال ألكساندرسون الأصلي وأبراج الهوائيات الخاصة به، الى جانب اجهزة ارسال الموجات القصيرة بهوائياتها ومنطقة سكنية تتضمن منازل العمال وقد عمد المهندس المعماري كارل اكيربلاد الى تصميم المبنى الرئيس حسب الطراز الكلاسيكي الجديد، أما أبراج الأسلاك الأشد ارتفاعاً في السويد في تلك الحقبة، فمن انجاز المهندس هنريك كروغر ويجسد هذا الموقع صورة فريدة لتطور الاتصالات، حيث أن المحطة هي الوحيدة المتبقية بين المحطات الكبيرة القائمة على التقنيات السابقة لعصر الالكترونيات 位于瑞典南部格里默通市的威堡广播站建于1922-1924年，是早期无线电通信的完好见证。该站由无线发射设备组成，包括6座高达127米的发射铁塔。尽管已经不再正常运转，但所有设备都保存如初。占地109.9公顷，除了放置原先的亚历山德森发射装置的建筑，包括发射塔及其天线和短波发射机及其天线之外，还有员工的住宅。建筑师Carl Åkerblad将主建筑设计成新古典主义风格，结构工程师Henrik Kreüger则负责天线塔的设计。天线塔是当时瑞典最高的建筑物。该遗产地是电讯事业发展的杰出代表，并且是现存唯一基于前电气技术建造的主要发射站。 это исключительно хорошо сохранившийся памятник инженерного искусства оставшийся от эпохи ранних беспроволочных трансатлантических коммуникаций включающей систему из шести стальных радиоантенн высотой 127 м Это оборудование хотя и не используется регулярно Архитектор Карл Окерблад спроектировал главные здания радиостанции в неоклассическом стиле а инженер Хенрик Креугер рассчитал конструкции башен для антенн которые были на то время самыми высокими сооружениями в Швеции la emisora de radio Varberg fue construida entre 1922 y 1924 Es un edificio monumental extraordinariamente bien conservado y muy representativo de la primera época del sistema de telecomunicaciones inalámbricas entre las dos orillas del Atlántico El sitio conserva el material de transmisión que comprende un conjunto de antenas formadas por seis torretas de acero de 127 metros de altura los equipamientos de la emisora se mantienen en estado de funcionamiento que tiene una superficie de109,9 hectáreas comprende varios edificios donde se hallan la emisora primigenia Alexanderson y varios transmisores de onda corta con sus correspondientes antenas así como una zona de viviendas para el personal El arquitecto Carl Åkerblad diseñó los edificios principales en estilo neoclásico y el ingeniero Henrik Kreüger se encargó de la construcción de las antenas que en su época fueron las estructuras de ingeniería más altas de toda Suecia La emisora Varberg constituye un testimonio excepcional del desarrollo de las telecomunicaciones y es el único ejemplo existente de una emisora de radio importante basada en la tecnología anterior a la era electrónica is an exceptionally well-preserved monument to early wireless transatlantic communication it lies within the “great circle” – an area without obstacles to radio waves – that is centred on New York the hub of the transatlantic transmitting system The station property consists of the transmitter equipment including the aerial system with six enormous steel towers each 127 metres high buildings housing the original Alexanderson transmitter and short-wave transmitters with their antennae as well as a residential area with staff housing and the antenna towers – the tallest constructions in Sweden at that time – were designed by structural engineer Professor Henrik Kreüger Although the station is no longer in regular use its equipment is maintained in operating condition This property is an outstanding illustration of the development of telecommunications being the only surviving example of a major transmitting station based on pre-electronic technology and stands as a testimony to the earliest part of a new era of communications Varberg is an outstanding monument representing the process of development of communication technology in the period following the First World War Varberg is an exceptionally well preserved example of a type of telecommunication centre representing the technological achievements by the early 1920s as well as documenting the further development over some three decades retains all the significant elements linked to early wireless telecommunication including the pre-electronic Alexanderson transmitter equipment housed in its neoclassical building as well as the comprehensive aerial system with towers and antennae Its boundaries thus adequately ensure the complete representation of the features and processes that convey the property’s significance does not suffer from any adverse effects of development and/or neglect It has been noted that the property is situated in an attractive part of Sweden that has witnessed a certain amount of development pressure though concentrated primarily in the coastal region It authentically (and uniquely) illustrates an important era in the history of human communication in terms of its forms and designs The Alexanderson installation has remained essentially unchanged since the time of its construction in 1922-1924 Any modifications reflect the fact that this station was in continuous operation until it was taken out of commercial use in 1960 it was used occasionally for military purposes The station originally included two Alexanderson alternators along with control equipment and auxiliary machinery One of these was dismantled and scrapped in 1960 but the second is well preserved and fully maintained in operating condition is essentially the same today as when it was constructed in 1923-1924 Minor modifications to these towers were undertaken during their forty years of commercial operation The condition of the transmitter hall is essentially the same as when it was inaugurated in 1925 It has undergone only minor modifications as the result of changing technical and administrative requirements This also applies to the station’s auxiliary buildings The houses used for the station’s staff are still used today these buildings have been renovated according to improvements in housing standards but the historic character of the residential area is preserved Several legal acts protect the attributes that sustain the Outstanding Universal Value of the property and regulate this historical site and its buffer zone and buffer zone are protected under the Historic Environment Act (1988:950) and the Planning and Building Act (1987); the radio station is designated an Area of National Interest for heritage conservation under the federal Environmental Code through the Halland County Administrative Board disposes funds which can be used for the care and maintenance of this property being undertaken by the Swedish Transport Administration involves the construction of a double track a new station and a tunnel through Varberg being undertaken by the Swedish Transport Administration (STA) The project is part of the expansion of Sweden’s West Coast line between Gothenburg and Lund. The West Coast line is a major transit line which runs along the west coast of the country  The expansion of the line involves building a fully expanded double track to improve capacity and reliability The Varberg Tunnel project will facilitate the accommodation of more trains and enable improved safety Construction on the project began in December 2019 was completed between 2015 and 2018 while the second phase The project will build an approximately 3.1km long tunnel under central Varberg and a 9km double track between Varberg and Hamra The Varberg to Hamra route connecting the Gothenburg and south-western Skåne regions serves as a key link to Copenhagen and other areas of Europe Varberg tunnel will include a 2.8km rock tunnel from Engelbrektsgatan in the city centre to Breared and a 300m concrete tunnel The project will involve the removal of the existing railway track and the shifting of the freight yard to the north of Varberg It will help remove the barrier effect in the central area of the city and improve connectivity with the sea The railway tracks will be beneath an open trough while entering Varberg from the north and will go into the tunnel from the station and south the project will involve the construction of a safety shaft under Varberg and the relocation of the current port The new Varberg station will be located 150m north of the current one linking the city centre with the new Västerport coastal canal district Its house will have a base of granite stone and a wave pattern in the surface The upper section will comprise wood and a wave-shaped ceiling the new station will have submerged platforms The first floor of the building will feature waiting rooms and amenities The second floor will have a staff area for traffic companies Bus squares will be built near the station to accommodate regional and city buses Other infrastructure will include taxi spots bicycle parking and dedicated parking spaces for persons with disabilities The current station will continue to operate until the new one is commissioned Construction of the station and the station area will begin after August 2023 and is expected to be completed in December 2024 The project will include bridges, tracks and civil engineering works. Construction is underway along the route for the tunnel and the double track It includes the creation of a new estate yard situated north of Lassabackarondellen and east of Naturum a southern tunnel estuary in Breared and a service and rescue tunnel in the railway park which is the first facility to be built as part of the tunnel project The bridge is being built south of the existing bridge and will allow the double track to fit under the bridge Other components of the project include a concrete trough new railway bridges over Österleden and Vareborg service roads and delay ponds for stormwater The entire project has a budget of Skr5bn ($621.3m) Region Halland and Jernhusen are contributing Skr2.4bn ($286.95m) Skr210m ($25.1m) and Skr60m-100m ($7.17m-11.95m) respectively Implenia was awarded a contract worth Skr3.5bn ($362m) in September 2019 for the planning and construction of tunnels It also includes 2.7km of track and a freight train station The STA selected Implenia for initial planning and preparation tasks in 2018 The municipality prepared the detailed plans and is working in association with the STA on various aspects of the project. Jernhusen will own and handle the management of the new station building Atkins was contracted to design the 3.1km tunnel and provide construction support Basler & Hofmann is the lead designer while Golder Associates is providing geotechnical and environmental consulting services Abako and Okidoki Arkitekter are under contract for construction work related to the track expansion and preparing the design for the new station along while Okidoki collaborated with O2 Landscape for further designing of the station and station area Mantum will supply material and undertake the shipment of shaft masses for the project while Svevia was tasked with carrying out the demolition of platform roofs at the Varberg railway station Give your business an edge with our leading industry insights View all newsletters from across the GlobalData Media network Metrics details The extravillous trophoblast cell lineage is a key feature of placentation and successful pregnancy Knowledge of transcriptional regulation driving extravillous trophoblast cell development is limited we map the transcriptome and epigenome landscape as well as chromatin interactions of human trophoblast stem cells and their transition into extravillous trophoblast cells We show that integrating chromatin accessibility and transcription factor binding motif enrichment enables identification of transcription factors and regulatory mechanisms critical for extravillous trophoblast cell development and EPAS1 in the regulation of extravillous trophoblast cell development EPAS1 is identified as an upstream regulator of key extravillous trophoblast cell transcription factors including ASCL2 and SNAI1 and together with its target genes is linked to pregnancy loss and birth weight we reveal activation of a dynamic regulatory network and provide a framework for understanding extravillous trophoblast cell specification in trophoblast cell lineage development and human placentation The contributions of EVT cells to uterine transformation and successful pregnancy imparts importance to understanding the acquisition of an EVT cell fate To date there is a limited knowledge of regulatory networks controlling EVT cell differentiation The execution of similar experimentation regarding human trophoblast cell development would be informative and associated transcriptional signatures in human TS cells and differentiated EVT cells have not been performed to date The experimentation included systematic assessments of the transcriptome by RNA-sequencing (RNA-Seq) chromatin accessibility using Assay for Transposase-Accessible Chromatin-sequencing (ATAC-Seq) and high throughput chromosome conformation capture (Hi-C) We integrated these analyses to identify higher-order regulation of human EVT cell differentiation which was validated by histone modifications (chromatin immunoprecipitation-sequencing ChIP-Seq) in the TS cell model and single-cell RNA sequencing (scRNA-Seq) of first trimester human placenta samples the analyses provide a rich resource for dissecting functional genomics of placental-related diseases of pregnancy we identified candidate TFs and demonstrated their critical role in EVT cell lineage development with links to pregnancy complications fetal (Endo f) and maternal endothelial cells (Endo m) syncytiotrophoblast and villous cytotrophoblast (SCT/VCT) and cells not determined (ND) and (b) EVT cell-specific genes detected using an in vitro model (red color scale of expression values thresholded at the 5th and 95th percentiles) c–e Plots depicting gene set enrichment analysis using three genes sets (each N = 250) of genes significantly upregulated in (c) SCT/VCT cells or (d) EVT cells or (e) genes not differently expressed between SCT/VCT and EVT cells from scRNA-Seq data sets and tested for enrichment for expression pattern in stem state (phenotype 1 Enrichment score (ES) reflects the degree of which each gene set is overrepresented at the extremes (top or bottom) of genes expressed in phenotype 0 (EVT cells) versus phenotype 1 (stem state cells) Estimated significance of ES were accounted for multiple testing and corresponded to (b) Phenotype 0; FDR q value = NS; Phenotype 1; FDR q value = 0.00190 (c) Phenotype 0; FDR q value = 0.00196; Phenotype 1; FDR q value = NS and (d) Phenotype 0; FDR q value = NS; Phenotype 1; FDR q value = 0.0016 FDR = false discovery rate; NS = not significant the in vitro human TS cell culture model can be successfully leveraged to gain insight into human EVT cell lineage development We use CT27 as our reference cell line for all subsequent global and targeted analysis with orthogonal validation in CT29 accordingly a Density plot and heatmap of coverages from extravillous trophoblast (EVT) and stem state assay for transposase-accessible chromatin (ATAC)-seq assays showing stem-specific (dark blue) and EVT-specific (yellow) regions centered around: EVT-specific peaks (top ranked based on peak score from EVT ATAC-Seq in descending order) ranked based on peak score from EVT ATAC-Seq in descending order) and stem state-specific peaks (bottom ranked based on peak score from stem state ATAC-Seq in descending order) Each row represents one genomic region centered around (5kb) a peak and the depth of coverage is encoded in a colorimetric scale (red to blue corresponding low to high coverage) b Bar graphs depicting the fraction of chromatin accessible regions across five defined genomic regions (e.g. transcription termination site (TTS; pink) promoter-transcription start site (TSS; dark blue) Chromatin accessible regions identified by ATAC-Seq are classified as regions (1) unique to stem state cells (2) shared between stem and EVT cells or (3) unique to EVT cells c Density plot and heatmap of coverages from EVT and stem state ATAC-Seq assays limited to genomic regions in EVT-specific peaks (left ranked based on coverage in EVT ATAC-Seq in descending order) ranked based on coverage in stem state ATAC-Seq in descending order) and shared peaks across cell states (right Each row represents one genomic region centered around (10 kb) a TSS and the depth of coverage is encoded in a colorimetric scale (red to blue corresponding low to high coverage) e Bar graphs depicting the fraction of differentially enriched chromatin accessible regions identified by ATAC-Seq in stem state (d) or EVT (e) cells across three chromatin states defined by histone modifications: H3K4me3 (putative poised promoters; green) H3K27ac (active enhancers; light blue) and H3K4me3+H3K27ac (active promoters; red) f Schematic depicting transcription factor (TF) analysis results and motifs for top identified TFs To characterize the regulatory regions identified by ATAC-Seq in further detail we integrated ChIP-Seq based histone modification data for stem state and EVT cells and noted enrichment of ATAC-Seq coverage near H3K27ac and H3K4me3 peaks for both stem state and EVT cells, respectively (Supplementary Fig. 5a) Contact matrices (chromosome 7) from stem (left) and extravillous trophoblast (EVT) cell (right) Hi-C contact maps Pixel intensity represents a normalized (balanced) number of observed loci pair contacts Contact maps are annotated with RefSeq gene positions (green tracks) and cell state-specific assay for transposase-accessible chromatin (ATAC)-Seq assay signals (blue tracks Selected regions exemplify the quantity of all loop anchors (black dots) versus EVT cell state-specific loop anchors (yellow squares) for a region mapping near an EVT cell-state specific transcription factor Contact maps include (a) 500 kb whole chromosome and (b) 5 kb resolution region subsets EVT cell-specific (differential) loops (yellow) with one anchor overlapping an EVT-specific regulatory element indicated by ATAC-Seq data (blue) with corresponding stem state regions (dashed lines) Density plots show open chromatin distribution relative to loop anchor centers (bp x-axis) for all (c) stem and (d) EVT cell loops (purple) Normalized bin densities shown for every 10 million total reads (y-axis) measured by ATAC-seq Regions below peak signals represent 1000 randomly selected control sets that do not intersect loops with 5 kb (blue) 10 kb (red) and 25 kb (green) region sizes Proportion of differential loop anchors in stem (e) and EVT (f) cells that mapped to a nearby (within 10 kb) gene Enrichment of significantly upregulated genes (RNA-Seq) shown for stem state (blue) and EVT (red) cells presented as fold-change (y-axis) Loop anchors link to significant vs non-significant genes (dotted line) P-values obtained from two-sided Fisher’s exact test g Genomic sub-region highlighted in (b) (yellow box) annotated with Hi-C H3K4me3 and H3K27ac ChIP-Seq assessments in EVT (top) or stem state (bottom) CT27 cells Regulatory elements near DLX5/DLX6 include Hi-C loops (red All datasets represented by individual tracks Yellow highlights regulatory regions overlapping loop anchors the potential contributions of TFAP2C to human TS cell maintenance and terminal trophoblast differentiation remain elusive syncytiotrophoblast and villous cytotrophoblast (SCT/VCT) and cells not determined (ND) scaled and natural-log transformed) for five transcription factors (ASCL2; DLX6; EPAS1 MYCN and SNAI1) shown in (a) Violin plots (shown as median and 25th and 75th percentiles; points are displayed as outliers if they are above or below 1.5 times the interquartile range) comparing EVT cells (orange N = 693 cells) with syncytiotrophoblast (SCT) and villous cytotrophoblast cells (VCT) combined (turquoise N = 7834 cells) and (b) UMAP feature plots (red color scale of expression values thresholded at the 5th and 95th percentiles) and EPAS1 in the regulation of trophoblast cell development and EVT differentiation a Representative human placental tissue specimen (12 weeks of gestation) probed for TFAP2C and PLAC8 transcripts using in situ hybridization 4′,6-diamidino-2-phenylindole (DAPI) labels cell nuclei Overlay of merged immunofluorescence images: TFAP2C (magenta) Scale bars represent 50 μm (CDH1 image panels) and 100 μm (PLAC8 image panels) b RT-qPCR measurement of TFAP2C normalized to POLR2A in stem (red) and extravillous trophoblast (EVT) cells (blue) Data were analyzed by unpaired t-test and are presented as mean values ± standard deviation (SD; ns = not significant p = 0.8374; n = 4 biologically independent replicates per group) c TFAP2C (50 kilodaltons (kDa)) and GAPDH (37 kDa) proteins in stem and EVT cells assessed by western blot analysis d Log2 fold-change values of normalized read counts of TFAP2C from RNA-Seq in stem state and days 3 and 8 of EVT cell differentiation compared to the stem state e RT-qPCR measurement of TFAP2C normalized to POLR2A in stem state cells transduced with lentivirus containing a control shRNA (shC; blue) or a TFAP2C-specific shRNA (gray) Data were analyzed by unpaired t-test and are presented as mean values ± standard deviation (SD; shTFAP2C; n = 4 biologically independent replicates per group; **p = 0.0029) f TFAP2C (50 kDa) and GAPDH (37 kDa) proteins in stem state cells transduced with shC or shTFAP2C and assessed by western blot g Phase contrast images of stem state cells transduced with shC or shTFAP2C normalized counts of selected differentially expressed transcripts generated from RNA-Seq in shC (control KD; blue) transduced cells using a red-blue diverging scale Transcripts are clustered into four groups including cell cycle (purple) *Depict genes identified as direct targets of TFAP2C based on ChIP-Seq analysis in stem state cells Graphs in panels (b) and (e) depict mean ± standard deviation Source data are provided as a Source Data file we conclude that TFAP2C contributes to cell cycle regulation mainly as a transcriptional activator and is critical for maintenance of TS cells in a stem state and early EVT cell lineage development a RT-qPCR measurement of SNAI1 (n = 5 biologically independent replicates per group) normalized to B2M in extravillous trophoblast (EVT) cells differentiated from stem state cells transduced with lentivirus containing a control shRNA (shC; blue) or SNAI1-specific shRNA (shSNAI1; gray) Data were analyzed by unpaired t-test and are presented as mean values ± standard deviation (SD) and **p = 0.0054 b SNAI1 (29 kilodaltons (kDa)) and GAPDH (37 kDa) protein in EVT cells from shC control or shSNAI1 treated cells measured by western blot c Phase contrast images of shC control or shSNAI1 EVT cells following eight days of differentiation normalized counts of selected transcripts generated from RNA-Seq in shC (control KD; blue) transduced cells (n = 3 biologically independent replicates per group) using a red-blue diverging scale Transcripts are clustered into three groups including EVT-specific (pink) and H3K4me3 and H3K27ac ChIP-Seq assessments performed in CT27 cells differentiated into EVT cells (top panel) or maintained in the stem state (bottom panel) Identified regulatory elements near SNAI1 are highlighted in orange and overlap Hi-C loops (red open chromatin by ATAC-Seq (counts per million mapped reads respectively (counts per million mapped reads Expression level is shown by RNA-Seq (transcripts per million All datasets are shown in individual tracks a EPAS1 (n = 3 biologically independent replicates per group) normalized to B2M in extravillous trophoblast (EVT) cells differentiated from stem cells transduced with control shRNA (shC; blue) or EPAS1-specific shRNA (shEPAS1; gray) lentivirus Data were analyzed by unpaired t-test and are presented as mean values ± standard deviation (SD) and ***p = 0.0002 b EPAS1 (120 kilodaltons (kDa)) and GAPDH (37 kDa) in EVT cells from shC control or shEPAS1 transduced cells c Phase contrast images of EVT cells (day 8) normalized counts of selected transcripts (RNA-Seq) in shC control (Ctrl blue) transduced cells (n = 3 biologically independent replicates per group) using a red-blue diverging scale Transcripts cluster into two groups (i) EVT-specific (pink) or (ii) stem state-specific (green) assay for transposase-accessible chromatin (ATAC)-Seq and H3K4me3 and H3K27ac chromatin immunoprecipitation (ChIP)-Seq assessments performed in EVT differentiated (top) or stem state (bottom) CT27 cells Regulatory elements near EPAS1 (orange) overlap Hi-C loops (red open chromatin identified by ATAC-Seq (counts per million (CPM) mapped reads and promoter or enhancer marks identified by H3K4me3 Brown circles denote SNPs associated with pregnancy loss (PL) or birth weight (BW) in large GWAS studies f Violin plot (shown as median and 25th and 75th percentiles; points are displayed as outliers if they are above or below 1.5 times the interquartile range) of EPAS1 in EVT cells from single-cell RNA-Seq analysis of human first trimester placental samples from control (Control N = 693 cells) or recurrent pregnancy loss (RPL Y-axis represents normalized and natural log transformed EPAS1 expression levels g Schematic of transcriptional regulatory hierarchy controlling EVT cell differentiation (BioRender) disruption of SNAI1 or EPAS1 each resulted in downregulation of EVT cell-specific transcripts This analysis identified EPAS1-regulated genes as detected by RNA-Seq analysis (log2 foldchange <−1; adjusted p < 0.05) being significantly correlated with chromatin accessible regions containing EPAS1 (HIF2A) binding motifs This corresponded to a 1.5-fold enrichment (Chi2 = 62; Fisher p < 0.0001) when considering all EVT cell peaks and a 2.5-fold enrichment when restricting to those EVT cell peaks with differential binding affinity (Chi2 = 71; Fisher p < 0.0001) Among these putative direct targets of EPAS1 action were PLAC8 Pregnancy failure in RPL may be exacerbated because EPAS1-driven adaptations are insufficient to sustain the pregnancy these predisposing EPAS1 genetic variants associated with pregnancy complications may lead to EPAS1 dysregulation and ineffective placentation leading to increased risk of placental disorders and population-based studies are needed to establish these relationships open and active chromatin by ATAC-Seq and ChIP-Seq of histone modifications human TS cells represent a remarkable high fidelity stem cell system with the capacity to exhibit many traits intrinsic to EVT cells developing in situ Later stages of differentiation associated with EVT cells penetrating the uterine parenchyma are unlikely to be captured as well in this cell culture model and would require additional refinements enhancers) controlling cell lineage development through involvement of master TFs regulating gene expression in EVT cells the appearance of increased enhancer-driven gene regulation in EVT versus stem state cells were confirmed by ChIP-Seq of histone modifications marking active enhancer regions (H3K27ac) EPAS1 mRNA and EPAS1 protein accumulate as EVT cells differentiate and do so independent of low oxygen tensions Mechanisms controlling EVT cell dependent EPAS1 transcriptional activation and EPAS1 protein stabilization are unknown Elucidation of factors controlling EVT cell EPAS1 will add to understanding the regulation of EVT cell differentiation and EPAS1 provide entry points and a framework for understanding EVT cell differentiation and human placentation The challenge will be to harness this knowledge to develop effective strategies for diagnosing and treating diseases of placentation This study using deidentified TS cells complies with all relevant ethical regulations as approved by the Human Research Protection Program and the Human Stem Cell Research Oversite Committee at the University of Kansas Medical Center who determined the study as non-human subjects’ research Prior approval for use of human placental tissue specimens was granted by the respective local human research ethics review committees at the Mount Sinai Hospital and the University of Kansas Medical Center The RPL study was approved by the Children’s Mercy Institutional Review Board (Study No Informed written consent was obtained from the RPL participants before study inclusion Participants were not compensated for study participation Human TS cells (CT27, 46, XX and CT29, 46, XY)22 were cultured in 100 mm tissue culture dishes coated with 5 μg/mL collagen IV (CB40233 Human TS cells were maintained in Complete Human TS Cell Medium [DMEM/F12 (11320033 1% Insulin-Transferrin-Selenium-Ethanolamine solution (ITS-X EVT cell differentiation was induced by plating human TS cells onto 6-well plates pre-coated with 1 μg/mL collagen IV at a density of 80,000 cells per well Cells were cultured in EVT Differentiation Medium [DMEM/F12 (11320033 the medium was replaced with EVT Differentiation Medium excluding NRG1 and with a reduced Matrigel® concentration of 0.5% On culture day 6 of EVT cell differentiation the medium was replaced with EVT Differentiation Medium excluding NRG1 and KSR Cells were analyzed in the stem state and at days 3 Cells were harvested from plates with trypsin and viability determined with a Countess II automated cell counter (Thermo-Fisher) Sample replicates with the highest viability and an adequate cell count were selected to be used for ATAC-Seq Cells used for RNA isolation were centrifuged at 300 × g for 8 min and cell pellets were resuspended in 1 mL of TRIzol (15596026 Cells in culture were washed with phosphate-buffered saline (PBS) and resuspended with 4% paraformaldehyde in PBS for 20 min at room temperature with gentle agitation and cell pellets were washed twice with PBS and stored at 4 °C Fixed cells were permeabilized with PBS containing 3% BSA and 0.2% Triton X-100 for 30 min at room temperature with gentle agitation Cells were washed with PBS and blocked with PBS containing 3% BSA for 15 min and then incubated overnight with anti-HLA-G-phycoerythin (1:1500 Cedarlane Labs) prepared in PBS containing 3% BSA and 0.2% Triton X-100 in the dark at 4 °C with gentle agitation and analyzed using a BD LSR II flow cytometer (BD Biosciences) at the University of Kansas Medical Center Flow Cytometry Core Laboratory Libraries were quantified using a Qubit dsDNA BR Assay Kit (Q32853 Thermo-Fisher) and the size was determined with a High Sensitivity DNA Bioanalyzer Kit (5067-4626 CA) and sequenced on a NovaSeq 6000 (Illumina EVT cell) were determined based on complete lack of overlap with a comparing set of peak regions (e.g. The webtool GREAT was used to retrieve genes with an overlapping regulatory domain where the regulatory domain of a gene is the region 5 kb upstream and 1 kb downstream of the transcription start site (TSS) distal gene elements were retrieved where the regulatory domain of the genes extends up to 1 Mb each peak was annotated by mapping it to the most significant differentially expressed gene (EVT vs stem) with a TSS within 10 kb of the peak region ATAC-seq read counts per peak were generated using the Bioconductor package DiffBind (Version 3.2.7) Peaks with <10 counts per million (CPM) were excluded The differential binding affinity of a region between EVT and stem cell samples was assessed in the Bioconductor package limma (Version 3.48.3) with an FDR of 0.05 Super-enhancers were called using HOMER (version 4.7.2) findpeaks (http://homer.ucsd.edu/homer/ngs/peaks.html) using the -style super mode RNA was isolated with a TRIzol/chloroform precipitation followed by a cleanup with a RNeasy Mini Kit (74104 Frozen cell isolates in TRIzol were thawed on ice prior to starting the isolation the samples were placed at room temperature for 5 min to promote dissociation of nucleoprotein complexes 200 μL of chloroform was added to each sample with vigorous shaking for 15 s Samples were placed at room temperature for 3 min before centrifugation at 12,000 × g for 15 min at 4 °C aqueous phase was removed and transferred to a new 1.5 mL tube and 1.5 volumes of 100% ethanol added Isolates containing ethanol were mixed thoroughly by pipetting and 650 μL transferred to a RNeasy spin column The protocol for the RNeasy Mini Kit was then followed to clean the sample post-TRIzol/chloroform extraction RNA was then quantified using a Qubit RNA BR Assay Kit and RNA integrity assessed using RNA ScreenTape (5067–5577 and 5067–5576 Agilent) on the Agilent TapeStation platform (Agilent) prior to library preparation RNA libraries were prepared using a TruSeq Stranded RNA HT Sample Prep Kit (RS-122-2303 Illumina on a Caliper Sciclone G3 platform (PerkinElmer Manual bead cleanup was performed using AMPure XP Beads (A63881 CA) after library preparation to remove primer-dimers 1.0x volume of beads was added to the entire library volume Samples were mixed by pipetting and incubated at room temperature for 5 min before being placed on a magnetic stand until the supernatant cleared and the beads were washed twice with 80% ethanol while still on the magnet and the beads were air-dried on the magnet for 5 min at room temperature 30 μL of Resuspension Buffer was added to each sample and the solution incubated for 2 min at room temperature Samples were then placed on a magnet until the supernatant was clear The supernatant was then transferred to a new plate A Qubit dsDNA BR Assay kit was used to determine the concentration of the library and a Fragment Analyzer Standard Sensitivity NGS Fragment Kit (DNF-473-10000 Agilent) was used to detect the size of the library and to verify removal of excess primer-dimers Standard Illumina Free-Adapter Blocking was performed on the libraries adapter-blocked libraries were loaded on a NovaSeq 6000 with a run configuration of 151 × 8 × 8 × 151 and an average depth of 70 M paired-end reads per library Raw FASTQ files were trimmed using default parameters (-r 0.1 -d 0.03) in Skewer (Version 0.2.2) and reads shorter than 18 bp were discarded Transcripts were quantified using Kallisto (Version 0.46.2) Differentially expressed genes at FDR of 0.05 were discovered using the Bioconductor package DESeq2 in R (Version 1.32.0) CT27 and CT29 RNA-sequencing data were processed individually following standard processing Peaks for each sample were called independently using the callpeak function in MACS3 (Version 3.0.0a6) with a minimum FDR of 0.01 (-q 0.01) Cells were rinsed with 5 mL of PBS and then 5 mL PBS containing 2% formaldehyde were added and incubated for 10 min 550 μL of glycine 1.25 M (final conc 0.125 M) were added and incubated for 5 min at room temperature before an additional 15 min incubation on ice Liquid was removed and cells were rinsed two times with 5 mL ice-cold PBS Cells were scraped and transferred into 2 mL low bind tubes to have the equivalent of 1 × 106 cells (1 Petri Dish) Nuclei were pelleted at 2500 rpm for 10 min at 4 °C (repeat if necessary) and all supernatant was removed and flash frozen on dry ice and stored at −80 °C until ready for use Crosslinked samples were thawed on ice and prepared for Hi-C using the Arima-HiC kit (Arima Genomics Cross-linking was performed according to the Arima-HiC protocol with the following modifications the incubation at 37 °C was increased to a duration of 60 min and the samples were maintained overnight at 4 °C after step 11 Samples were then cleaned with AMPure XP Beads as described in the protocol and all quantification and quality control steps that required the use of a Qubit were performed using a Qubit dsDNA HS Assay Kit Proximally ligated DNA (1000 ng/sample) was used as an input into the library preparation protocol Samples were sheared to 400 bp using a Covaris LE220-plus system using the manufacturer’s recommended settings Sizing was confirmed using a High Sensitivity DNA Bioanalyzer kit Size-selection as described in the Arima-HiC protocol was followed and the entire size-selected sample was used as input into biotin enrichment and library preparation with a KAPA HyperPrep kit and Roche SeqCap Adapters (7141530001 or 7141548001 Instead of performing the Arima-HiC quality control step 2 the number of cycles needed for library amplification was determined as follows: perform 10 PCR cycles for 125–200 ng of input perform 9 PCR cycles for 200–400 ng of input perform 8 PCR cycles for 400–600 ng of input and perform 7 cycles of PCR for inputs >600 ng The completed libraries were then quantified using a Qubit dsDNA BR Assay Kit and the library size was determined with a High Sensitivity DNA Bioanalyzer Kit adapter-blocked libraries were loaded on a NovaSeq 6000 with a run configuration of 151 × 8 × 8 × 151 and an average depth of 900 M PE reads per library genes with a TSS within 10 kb of a loop region were linked to each loop The Bedtools toolkit was used to compute the depth of coverage of the ATAC read data genome-wide in 100 bp bins normalizing number of ATAC reads in each bin for every 10 M total reads for a given sample All bins within 20 kb of either end of each of the EVT and stem cell loops were then extracted 1000 randomly selected intervals (chose from chr1-22 Y) that do not intersect any of the loops and do not intersect our list of blocked regions were generated Three different control sets with intervals of size 5 kb All ATAC bins within 20 kb of the intervals in each of these control sets were extracted Number of bins was set to 20 and the obs/exp transformation was used for the contact matrix Heatmaps were generated with Juicebox 1.11.08 Study participants were screened at the University of Kansas Health System Advanced Reproductive Medicine Clinic All study participants had transvaginal ultrasound to confirm diagnosis of miscarriage Fetal sex was determined from clinical cytogenetics testing but was not considered in any analysis as this was out of the scope of the study Each sample was rinsed in PBS before the addition of 5 mL of Digestion Medium [DMEM/F12 (11320033 and 100 units/mL of penicillin and 100 μg of streptomycin (15140122 Thermo-Fisher) with 2.0 mg/mL collagenase type 1A] and incubated for 50 min at 37 °C The sample was strained through a pre-wetted 100 μm filter in a 50 mL conical tube and rinsed twice with 5 mL of DMEM/F12 with 10% FBS and 100 units/mL penicillin and 100 μg/mL streptomycin and centrifuged at 300 × g for 8 min Cell pellets were resuspended in 1 mL of cold Recovery Cell Culture Freezing Medium (12648010 and the cell suspension was transferred to a cryogenic storage vial The cryogenic storage vial was placed in a Corning CoolCell FTS30 which was then placed in a −80 °C freezer overnight Samples were stored at −80 °C before being thawed and processed for single-cell RNA-Seq cDNA and library preparation was performed identically for all samples using the Chromium Single Cell 3’ Library & Gel Bead Kit v3 (1000075 10x Genomics) according to the manufacturer’s protocol Libraries were sequenced with a NovaSeq 6000 using 2 × 94 cycle paired-end Sequenced reads were initially processed by the CellRanger pipeline which includes FASTQ creation The Cell Ranger GRCh38(v2020-A) genome was used as the reference for alignment For differential expression analysis, genes were filtered according to the parameters used for Vento-Tormo dataset28 The raw UMI counts of samples with multiple captures were summed prior to differential expression analysis For a gene to be significantly differentially expressed the Benjamini-Hochberg adjusted p-value was <0.05 as well as a gene set representing genes not differentially expressed) Normalized gene expression count for each EVT (n = 6 biologically independent replicates) and stem (n = 6 biologically independent replicates) cell state from the TS cell in vitro model was used with EVT and stem labeled as phenotype 0 and 1 Data from the scRNA-Seq assays were normalized and scaled with the NormalizeData and ScaleData functions of Seurat79 Violin plots and feature plots were then generated using default parameter with the latter using expression values thresholded at the 5th and 95th percentiles using the FeaturePlot parameters “min.cutoff = q5” and “max.cutoff = q95” Sections of paraffin-embedded first trimester placenta tissue were obtained from the Lunenfeld-Tanenbaum Research Institute (Mount Sinai Hospital Fluorescence images were captured on a Nikon 90i upright microscope (Nikon) with a Photometrics CoolSNAP-ES monochrome camera (Roper) shRNA sequences were subcloned into a pLKO.1 vector at restriction sites for AgeI and EcoRI The three lentiviral packaging vectors included pMDLg/pRRE (plasmid 12251) Lentiviral particle production followed transient transfection of both the shRNA-pLKO.1 vector and packaging plasmids into Lenti-X cells (632180 Lenti-X cells were plated in 0.001% poly-L-lysine (P4707 Sigma-Aldrich) in PBS-coated 6-well tissue culture-treated plates Transient transfection was performed with Attractene (301005 Thermo-Fisher) with 100 U/ml penicillin and 100 μg/ml streptomycin (15140122 Lenti-X cells were cultured in DMEM plus 10% FBS and 100 μg/ml streptomycin until 24 h prior to supernatant collection at which time the Lenti-X cells were cultured in Basal Human TS Cell Medium [DMEM/F12 (11320033 1% Insulin-Transferrin-Selenium-Ethanolamine solution (vol/vol and 50 ng/mL epidermal growth factor (E9644 Viral supernatants were collected at 24 and 48 h post-basal human TS cell medium change and stored at −80 °C human TS cells were plated at 80,000 cells per well in six-well tissue culture treated plates coated with 5 μg/mL collagen IV (CB40233 and human TS cells were incubated with 2.5 μg/mL polybrene for 30 min at 37 °C Following polybrene treatment human TS cells were transduced with 500 μL of lentiviral supernatant and incubated for 24 h Culture medium was changed 24 h post-transduction and transduced cells were selected with puromycin dihydrochloride (5 μg/mL Recovered human TS cells were cultured for 1–3 days in Complete Human TS cell Medium prior to use in assays Amplification and fluorescence detection were measured with a QuantStudio 5 Flex Real-Time PCR System (Thermo-Fisher) 10 min) preceded 40 cycles of a two-step PCR (92 °C 1 min) and was followed by a dissociation step (95 °C The comparative cycle threshold method was used for relative quantification of the amount of mRNA for each sample normalized to housekeeping genes B2M or POLR2A Statistical analyses were performed using GraphPad Prism 8 software or Two-way ANOVA tests were applied when appropriate Data is represented as mean ± standard deviation with the statistical significance level set at p < 0.05 Statistical test details and p values are presented in figure legends Cell lysates were sonicated in radioimmunoprecipitation assay (RIPA) lysis buffer (sc-24948A Protein concentrations were measured with the DC Protein Assay (5000112 Bio-Rad) and RIPA buffer was used as the blank standard Proteins were separated by SDS-PAGE and transferred onto polyvinylidene difluoride (PVDF) membranes (10600023 PVDF membranes were blocked with 5% non-fat milk in Tris-buffered saline with 0.1% Tween 20 (TBST) and probed with primary antibodies to SNAI1 (1:1000 and glyeraldehyde-3-phosphate dehydrogenase (GAPDH PVDF membranes were washed three times for 5 min each with TBST and incubated with secondary antibodies (goat anti-rabbit IgG HRP Cell Signaling Technology and horse anti-mouse IgG HRP Cell Signaling Technology) for 1 h at room temperature Immunoreactive proteins were visualized using the LuminataTM Crescendo Western HRP Substrate (WBLUR0500 MA) according to the manufacturer’s instructions Full scan blots are presented in the Source Data file Stranded mRNA-Seq was performed using a NovaSeq 6000 Quality control was completed using the Agilent TapeStation 4200 with the RNA ScreenTape Assay kit (Agilent Technologies 5067–5576) Total RNA (1 μg) was used to initiate the library preparation protocol The total RNA fraction was processed by oligo dT bead capture of mRNA ligation with the appropriate Unique Dual Index (UDI) adaptors and library amplification by PCR using the Universal Plus mRNA-Seq with NuQuant library preparation kit (0520-A01 Library validation was performed using the D1000 ScreenTape Assay kit (5067–5582 The concentration of each library was determined with the NuQuant module of the library prep kit using a Qubit 4 Fluorometer (Thermo-Fisher/Invitrogen) Libraries were pooled based on equal molar amounts and the multiplexed pool was quantified using the Roche Lightcycler96 with FastStart Essential DNA Green Master (06402712001 Roche 0) and KAPA Library Quant (Illumina) DNA Standards 1–6 (KK4903 the RNA-Seq library pool was adjusted to 2.125 nM for multiplexed sequencing Pooled libraries were denatured with 0.2 N NaOH (0.04 N final concentration) and neutralized with 400 mM Tris-HCl A dilution of the pooled libraries to 425 pM was performed in the sample tube on the instrument and followed by onboard clonal clustering of the patterned flow cell using the NovaSeq 6000 S1 Reagent Kit (200 cycle) (20012864 A 2 × 101 cycle sequencing profile with dual index reads was completed using the following sequence profile: Read 1 – 101 cycles x Index Read 1 – 8 cycles x Index Read 2 – 8 cycles x Read 2 – 101 cycles sequence data were converted from.bcl file format to fastq file format using bcl2fastq software and de-multiplexed into individual sequences and downstream analysis performed as described above Summary statistics from UK Biobank GWAS was accessed at http://www.nealelab.is/uk-biobank Odds ratio of the proportion of nominally significant (P < 0.05) hits in the EPAS1 gene region (GRCh38; chr2:46,150,000–46,450,000) was computed and compared with variants in a randomly selected matched window This step was repeated 1000 times for each phenotype to generate a distribution of odds ratio To compute significance using Wilcoxon test a null distribution was generated to compare against another randomly selected matched window size was selected and compared with the first randomly selected region chosen in step 1 No statistical method was used to predetermine sample size No data sets derived from the human TS cell model were excluded from any analyses All genome-wide data sets were done on two independent TS cell donor lines Experiments utilizing the TS cell model were independently repeated a minimum of three times for all results from experiments displayed as representative data (e.g. immunolocalization and immunocytochemistry images) Cause of pregnancy loss was blinded during data integration and initial analysis that included filtering and clustering of the data Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article Only publicly available tools were used in data analysis as described wherever relevant in the Methods The placental bed: from spiral arteries remodeling to the great obstetrical syndromes Function and control of human invasive trophoblast subtypes: intrinsic vs Human placenta and trophoblast development: key molecular mechanisms and model systems Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy Examination of transcriptional networks reveals an important role for TCFAP2C and EOMES in trophoblast stem cell maintenance Distinct histone modifications in stem cell lines and tissue lineages from the early mouse embryo Endogenous retroviruses function as species-specific enhancer elements in the placenta Elf5-centered transcription factor hub controls trophoblast stem cell self-renewal and differentiation through stoichiometry-sensitive shifts in target gene networks Fgf and Esrrb integrate epigenetic and transcriptional networks that regulate self-renewal of trophoblast stem cells Mechanisms of transcription factor-mediated direct reprogramming of mouse embryonic stem cells to trophoblast stem-like cells Super-enhancer-guided mapping of regulatory networks controlling mouse trophoblast stem cells Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells Extensive nuclear reprogramming underlies lineage conversion into functional trophoblast stem-like cells Direct induction of trophoblast stem cells from murine fibroblasts MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells Changes in the enhancer landscape during early placental development uncover a trophoblast invasion gene-enhancer network Dynamic regulation of AP-1 transcriptional complexes directs trophoblast differentiation ASCL2 reciprocally controls key trophoblast lineage decisions during hemochorial placenta development A combination of criteria define human first-trimester trophoblast Derivation of human trophoblast stem cells Takahashi, S. et al. Loss of p57KIP2 expression confers resistance to contact inhibition in human androgenetic trophoblast stem cells. Proc. Natl Acad. Sci. USA https://doi.org/10.1073/pnas.1916019116 (2019) TEAD4 ensures postimplantation development by promoting trophoblast self-renewal: an implication in early human pregnancy loss Placentation defects are highly prevalent in embryonic lethal mouse mutants Intersection of regulatory pathways controlling hemostasis and hemochorial placentation A single-cell survey of the human first-trimester placenta and decidua Single-cell reconstruction of the early maternal-fetal interface in humans Index and biological spectrum of human DNase I hypersensitive sites Integrative analysis of 111 reference human epigenomes A bivalent chromatin structure marks key developmental genes in embryonic stem cells Enhancers and super-enhancers have an equivalent regulatory role in embryonic stem cells through regulation of single or multiple genes Super-enhancers in the control of cell identity and disease A 3D map of the human genome at kilobase resolution reveals principles of chromatin looping Subtle changes in chromatin loop contact propensity are associated with differential gene regulation and expression Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation Juicer provides a one-click system for analyzing loop-resolution Hi-C experiments and polyploidy in human extravillous trophoblast Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta Wnt-dependent T-cell factor-4 controls human extravillous trophoblast motility Dlx5 and Dlx6 can antagonize cell division at the G1/S checkpoint A genome-wide CRISPR-Cas9 knockout screen identifies essential and growth-restricting genes in human trophoblast stem cells Pivotal role of the transcriptional co-activator YAP in trophoblast stemness of the developing human placenta GATA2/3-TFAP2A/C transcription factor network couples human pluripotent stem cell differentiation to trophectoderm with repression of pluripotency Reprogramming roadmap reveals route to human induced trophoblast stem cells OVO-like 1 regulates progenitor cell fate in human trophoblast development a new marker for human interstitial extravillous trophoblast cells Dynamics of trophoblast differentiation in peri-implantation-stage human embryos LSD1 ablation stimulates anti-tumor immunity and enables checkpoint blockade The multifaceted role of GCM1 during trophoblast differentiation in the human placenta The snail superfamily of zinc-finger transcription factors Altered expression of epigenetic regulators and imprinted genes in human placenta and fetal tissues from second trimester spontaneous pregnancy losses mediates hypoxia-induced up-regulation of Flt-1 gene expression in placental trophoblasts Adaptive mechanisms controlling uterine spiral artery remodeling during the establishment of pregnancy Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors The uterine spiral arteries in human pregnancy: facts and controversies Epigenomic analysis of multilineage differentiation of human embryonic stem cells Chromatin architecture reorganization during stem cell differentiation Developmental clock and mechanism of de novo polarization of the mouse embryo Epithelial-mesenchymal transition during extravillous trophoblast differentiation and regulation of hypoxia-inducible transcription factors in the human placenta Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor HIF-1 and HIF-2 transcription factors-similar but not identical Selective overexpression of the hypoxia-inducible transcription factor Derivation of trophoblast stem cells from naïve human pluripotent stem cells Naive human embryonic stem cells can give rise to cells with a trophoblast-like transcriptome and methylome An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues The ENCODE blacklist: identification of problematic regions of the genome BEDTools: a flexible suite of utilities for comparing genomic features Galaxy HiCExplorer 3: a web server for reproducible Hi-C capture Hi-C and single-cell Hi-C data analysis Simple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities Practice Committee of the American Society for Reproductive Medicine Definitions of infertility and recurrent pregnancy loss: a committee opinion American College of Obstetricians and Gynecologists’ Committee on Practice Bulletins—Gynecology Integrated analysis of multimodal single-cell data Normalization and variance stabilization of single-cell RNA-seq data using regularized negative binomial regression glmGamPoi: fitting Gamma-Poisson generalized linear models on single cell count data Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 Heavy-tailed prior distributions for sequence count data: removing the noise and preserving large differences Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes Download references The research was supported by the National Institutes of Health (F32HD096809 (K.M.V.) and AMED Grant Number JP22gm1310001 (T.A.) Present address: Department of Obstetrics and Gynecology Northwestern University Feinberg School of Medicine Present address: Department of Trophoblast Research Institute of Molecular Embryology and Genetics These authors contributed equally: Kaela M Institute for Reproductive and Developmental Sciences Department of Pathology & Laboratory Medicine Tohoku University Graduate School of Medicine conceived and designed the research; K.M.V. analyzed the data and interpreted results of experiments; K.M.V. prepared figures and drafted manuscript; K.M.V. edited and revised manuscript; All authors approved the final version of manuscript The authors declare no competing interests Nature Communications thanks Jan Brosens and the other anonymous reviewer(s) for their contribution to the peer review of this work Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41467-023-40424-5 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science the project is articulated in the shape of an elongated stylised wave the design by white arkitekter represents the idea of fluidity synonymous with the tower’s task of storing water the striking geometry is also designed to be recognisable from afar across the landscape while the horizontality complements the region’s flat topography the positioning of the water tower is proposed to achieve a dramatic and sculptural silhouette while appearing very narrow when experienced from the front the stretched profile is created by placing two narrow cisterns one after the other horizontally the resulting elongated shape is also a nod to the famous infrastructure in the area as the landscape is characterized by the rows of wind turbines along the motorway that cut through the landscape and the multiple antennae of the long-wave transmitter at the UNESCO world heritage site in essence, white arkitekter presents a new visual marker for varberg that passers-by can enjoy the smooth horizontal curvature of the façade UPDATE: this project has been shortlisted in the ‘future projects – competition entries’ and ‘future projects – infrastructure’ categories at the 2019 world architecture festival architect: white arkitekter AXOR presents three bathroom concepts that are not merely places of function but destinations in themselves — sanctuaries of style The city of Varberg is ideally located in the historic city centre right next to the coastline and boasts a rich and diverse countryside Our location is exceptional – right in between two of Sweden’s fastest-growing regions The Greater Gothenburg region and the Greater Copenhagen region The Swedish Government is investing heavily in the west coast railway to increase the capacity for commuting and to connect cities and regions along the way this means our section of the railway will be in a tunnel under the city centre we will move parts of our harbour and have already begun planning for a new waterfront area that connects the city centre with the coastline Varberg was “discovered” by people in Sweden’s bigger and more industrial cities coincided with the larger availability of cars to a greater number of people the towns along the south-west coast of Sweden were mostly dependent on the fishing and farming industries but suddenly the tourist sector exploded when the demand for city people to take a summer holiday on the coast increased Varberg is one of the cities that has really flourished because of this development whereas others flourished for a while and then slowly went into a quiet slumber That Varberg is different from other communities is obvious in so many ways It can largely be attributed because there is a high level of entrepreneurship here indeed there is a very diverse business sector in the municipality This ranges from the large-scale industrial production of timber to countless hotels and restaurants that serve Varberg as one of Sweden’s most popular spa and coast resorts – all year round but more and more people discover the city as a place to settle down It’s less than an hour away by car or train to Sweden’s second largest city (Gothenburg) and the airport of Landvetter Varberg is really making the best of its fortuitous position today The building boom in Sweden is also apparent here indeed new residential areas are the results of wise planning for developing former industrial properties and using fill in sites to make the city more interesting for everyday life Although most of the development for housing is focused on the city we strive to involve residents living in our more rural communities too We engage people in the decisions that have the greatest effect on their everyday life we work together to see where public and commercial service infrastructure and housing will come to best use It is also a way for our citizens to meet with local politicians and decision-makers and share their thoughts about how the municipality can be made even more attractive A sustainable society needs to be based on people empowerment and the foundations of democracy New forms of meetings are important for reinventing the community We are building a community converging around means of public transportation and a sustainable lifestyle and website in this browser for the next time I comment Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Open Access Government produces compelling and informative news and academic research articles for the public and private sector looking at health As a Crossref Sponsored Member we are able to connect your content with a global network of online scholarly research currently over 20,000 other organizational members from 160 countries Crossref drive metadata exchange and support nearly 2 billion monthly API queries facilitating global research communication AMSTERDAM, April 9, 2024 /PRNewswire/ -- Milence announces its first charging hub in the Nordics Milence is committed to a fossil-free future for road transport the company is rolling out the first large-scale public electric charging network across Europe for heavy duty vehicles and buses An accessible charging hub in a key logistics point In late 2023 Milence opened the first charging hub in Venlo the company announced an agreement with Port of Antwerp-Bruges to develop two charging hubs with thirty charging bays for heavy duty vehicles Milence expands its future network towards the Nordics and commits to develop the first Milence' charging hub in Sweden The charging hub is strategically located in the municipality of Varberg between Gothenburg and Malmö in the south-west of Sweden The city itself is a popular stop off point for haulers and heavy-duty vehicle drivers and the charging hub holds a strategic position near exit 55 along the E6 motorway The hub in Varberg - as well as all other Milence charging hubs – will be open to all trucks regardless of brand A two phase development in Varberg The company is developing its network focusing on creating green corridors for road transport that connect key logistical points The development of the charging hub in Varberg marks the first step of electrifying transport routes in the Nordics Milence wants to create a holistic charging experience with their charging hubs by providing a space where drivers can rest and recharge The site in Varberg will include several facilities including a lounge as well as showers and toilets also accessible for people with disabilities The development of the charging hub in Varberg will be carried out in two phases: expressed her enthusiasm about the first hub in Sweden: "Recently we announced multiple sites in Western Europe and I am delighted we can now announce the development of our first site in the Nordics The new charging hub in Varberg is strategically located in a key logistics area in the south-west of Sweden our initiative to create high-performance green corridors across Europe is gaining momentum We have more plans to expand our network with several key sites this upcoming year some of which are already under contract and in development and all of which are located along key strategic areas and open to all trucks." About Milence Milence is dedicated to making the future of road transport fossil-free To realize this vision Milence is building a reliable charging network for all battery-electric heavy-duty trucks and coaches they aim to have at least 1,700 high-performance charging points across Europe Milence was established in July 2022 as a joint venture between Daimler Truck Photo - https://mma.prnewswire.com/media/2381267/Milence_Charging_Hub.jpgPhoto - https://mma.prnewswire.com/media/2381268/Milence_Charging_Hub.jpg Do not sell or share my personal information: Reports appeared in the Swedish press on Tuesday about a second MRI accident that occurred in the coastal town of Varberg in April This follows the recent incident at Sunderby Hospital in Luleå where forensic experts have now completed their site inspection The April accident involved a staff member at the Halland hospital in Varberg who was accompanying an anxious patient into the MRI scanner room, according to a report in Aftonbladet an established Stockholm-based tabloid newspaper with a daily print circulation of 155,000 The staff member was wearing a metallic ankle band with steel balls and the person's leg reportedly got stuck to the scanner but the machine had to be shut down for more than two weeks The total cost to the hospital was around 1 million Swedish krona (94,000 euros) deputy head of x-ray operations in Halland Other media outlets, including Hallands Nyheter, SVT Nyheter, and Teller Report have also posted information about the April accident Varberg has a population of about 30,000 and is located approximately 500 km southwest of Stockholm The town is known for its historic pier and sandy beaches and rocky terrain In Luleå, Swedish Lapland, forensic scientists have completed their work at the scene of the accident that took place on 23 October at a mobile MRI unit an investigator at the police's environmental crime unit "We needed to check if there was anything wrong and if there was any evidence of criminal activity," he said "We still need to speak to many people who were involved -- the nurse Things will become much clearer to us in another month or two." Wallerström believes the MRI unit at Luleå is the country's only mobile scanner Aleris owns the equipment and MR trailer and employs the injured specialist nurse He declined to give any specific details about the forensic team's work but they had removed objects that were thought to be of interest He said that investigators were concentrating their efforts on the garment -- referred to as a "weighted vest" in media reports -- worn by the specialist nurse Wallerström said he has never before conducted any similar investigations His previous investigations included a fatal accident in June 2017 in Abisko when a 21-year-old fencing contractor was killed by a train more Swedish radiologists have been reacting to the accident in Luleå so sooner or later one of these almost improbable things will happen," Dr. Torkel Brismar an associate professor of radiology at Karolinska University Hospital's Huddinge site in Stockholm the security and risk awareness at MRI departments is very high." Another Swedish radiologist who did not wish to be named said that from what he has read in the daily newspapers it sounds like it was simply a case of user error One theory is the specialist nurse probably thought the vest contained sand or lead but in fact it contained fine particles of iron ore It appears no one knew that the proper procedure in such cases is to quench the magnet; instead the hospital security guard used his knife to cut the nurse free It's also unclear at present whether the unit at Sunderby Hospital is The mobile system was seemingly there because of long waiting lists in the region "I am not aware how many there are," said Dr. Hans Ringertz professor emeritus at the Karolinska Institute in Stockholm "It would make sense to use them up in the sparsely populated areas in the north But Sweden might have decided on stationary units in the same way that Norway has a whole network of CT or MR units along the coastline up north." Ringertz said he's been told that some Norwegian MRI units perform less than 100 teleradiology exams per year "It is all a question of using the oil money to provide equal healthcare to everybody even in very sparsely populated parts of Norway." proclaimed in 2011 by Member States of UNESCO and adopted by the United Nations General Assembly in 2012 as an International Day to highlight the importance of radio Radio is a powerful medium for celebrating humanity in all its diversity radio remains the most widely consumed medium This unique ability to reach out to the widest audience means radio can shape a society’s experience and stand as an arena for all voices to speak out To commemorate World Radio Day this year, the Municipality of Varberg in southern Sweden chose Aleksandra Stratimirovic´s Transmission as an art installation to be inaugurated at Grimeton Radio Station, Varberg (Sweden) The choice was made through a jury selection with art experts together with representatives from World Heritage Grimeton This art installation consists of two laser projectors placed on one of the radio station's antenna towers; the station's communications will be visible through the laser beams Patterns in the shape of waves and frequencies convey messages in slow pulsating at intervals that mimic the Morse alphabet “This transmission has the ability to visualize Grimeton´s exciting history and to make visible the invisible It will be a monument to communication and to the values of the site,” said Bodil Hedberg Petersson art coordinator at the Municipality of Varberg The light becomes letters that then form words conveying messages built on UNESCO's vision of peace and human equality: peace The artwork is intended to be interactive and bring awareness of World Heritage preservation “The choice of technology means special demands on both artist and our organization but an exciting challenge which gives the project an extra dimension,” said Camilla Lugnet Managing Director at the Foundation World Heritage Grimeton Varberg is an attractive community on the south west coast of Sweden with a long history of growth 2017 marked the year where the municipality experienced 60 years of continuous population growth Only 14 municipalities in Sweden have achieved this The city of Varberg is one of the most attractive cities in Sweden ideally located with the historic city centre next to the coastline and with a rich and diverse rural countryside Varberg is positioned between two of Sweden’s fastest growing regions – the Greater Gothenburg region and the Greater Copenhagen region The Swedish government is investing heavily in the west coast railway to increase the capacity for commuting and to connect cities and regions along the way this means that the railway will be located in a tunnel under the city centre we will move parts of our harbour and have begun planning for a new waterfront area that connects the city centre with the coastline the city of Varberg was ‘discovered’ by people in Sweden’s bigger and more industrial cities This of course coincided with the greater availability of cars the towns along the south west coast of Sweden were mostly dependent on fishing and farming but suddenly the tourist sector exploded when city people needed a summer holiday on the coast The city of Varberg’s dissimilarity to other communities is obvious in so many ways there is a very diverse business sector in the municipality – from the large-scale industrial production of timber to countless hotels and restaurants that serve Varberg as one of Sweden’s most popular spa and coastal resorts – all year round but more and more people are discovering the city as a place to settle down With less than an hour by car or train to Sweden’s second largest city Varberg is really making the best of its fortuitous position The building boom in Sweden is also apparent here and new residential areas are the result of wise planning for developing former industrial properties and using fill-in sites to make the city more interesting for everyday life It is important for us that it is possible to lead a good life within the entire municipality we strive to involve those residents living in our more rural communities too It is also a way for our citizens to meet with local politicians and decision makers and share their thoughts about how the municipality can be made even more attractive This is becoming ever more important as decision making is moving farther and farther away from the people and a strong focus on the social and cultural aspects of sustainability are at the very heart of ensuring that the Municipality of Varberg takes its position as the Swedish west coast’s creative hotspot A sustainable society needs to be based on the empowerment of people and the foundations of democracy; new forms of meetings are important for reinventing the community we wish to involve people in the creative process converging around the means of public transportation and sustainable lifestyles Our momentum shows in the many awards we have been presented with The Municipality of Varberg was appointed Sweden’s ‘Most Liveable’ in the category for smaller communities and has received the award for four consecutive years Our thriving city centre was recently the winner in Sweden’s City Centre of the Year award And living in the wonderful coastal province of Halland it is certainly very fitting that Varberg’s yearly event We are proud of these awards and all the people that have worked so hard to make them possible; we regard these awards as being indicative of the future path for our city Innovation News Network brings you the latest research and innovation news from the fields of science Disclaimer: This website is an independent portal and is not responsible for the content of external sites.Please Note: Phone calls may be recorded for training and monitoring purposes.© Pan European Networks Ltd Archive Architecture Skip to ContentEnergy Drinks All Red Bull Energy Drinks Discover © Varberg MTB TeamMTBThis is Sweden’s latest XCO World Cup teamVarberg MTB Team is a brand new UCI team with five up-and-coming riders ready to take on the Swedish and the international race scene in 2022 1)*1.13793)}@media screen and (min-width:375px){.inline-heading__title{font-size:calc((24.66875px + .355vw)*var(--title-font-size-factor 1)*1.09756)}@media screen and (min-width:375px){.inline-heading--chapter .inline-heading__title{font-size:calc((26.56225px + 1.1834vw)*var(--title-font-size-factor 1))}}@media screen and (min-width:1220px){.inline-heading--chapter .inline-heading__title{font-size:41px}}@media(min-width:1000px){.inline-heading--chapter .inline-heading__title{margin-left:24px;width:calc(66.66% - 8px)}}@media(min-width:1200px){.inline-heading--chapter .inline-heading__title{margin-left:24px;width:calc(74.9925% - 6px)}}.inline-heading__chapter{color:var(--title-color,#000f1e73);font-size:31px;line-height:calc(var(--title-line-height-factor 1)*1.09756);margin-bottom:20px}@media screen and (min-width:375px){.inline-heading__chapter{font-size:calc((26.56225px + 1.1834vw)*var(--title-font-size-factor ";left:-45px;text-align:right;width:25px}Part of this story Watch the highlights from the first cross-country event of the season in Albstadt Everyone on the team are childhood friends Hugo Eriksson stoked about the 2022 race season Albstadt's XCO course has plenty of steep climbs © Bartek Wolinski / Red Bull Content Pool Hugo Eliasson ready to take on the new season About us | Advertise with us | Contact us Posted: 16 January 2020 | Global Railway Review | No comments yet The Varberg tunnel contract was awarded to Atkins who are now responsible for the detailed planning of the construction phase The contract to create a detailed design and construction support for a new tunnel in Varberg, Sweden, has been awarded to Atkins The project is part of a larger programme to expand the country’s 300km Gothenburg to Lund West Coast Line The tunnel is to be constructed underneath the coastal town of Varberg spanning the length of 3.1km and working to accommodate the line’s expansion to a double track railway The aim of the project is to increase capacity and reduce travel times for passenger and freight services CEO of Atkins Sweden, Johannes Erlandsson, said: “The Varberg tunnel and the line expansion will benefit the entire west coast of Sweden by connecting towns Having been involved since its early stages we now look forward to working with our partners to deliver this complex and transformative project.” The first phase of the design project has already reached completion which included the development of the implementation plan Detailed planning for the construction phase is now required under a time and materials contract worth approximately £13 million The railway expansion project – managed by the Swedish Transport Administration and Swiss construction company approximately 85 per cent of the West Coast Line has been upgraded The expansion is expected to be completed by 2025 Infrastructure Developments, Tunnelling Atkins, SNC-Lavalin Europe Johannes Erlandsson By Global Railway Review No comments yet All subscriptions include online membership giving you access to the journal and exclusive content By Elizabeth Jordan - Global Railway Review, Tom Bartley By Gabriel Higgins By Elizabeth Jordan - Global Railway Review Comment * document.getElementById("comment").setAttribute( "id" "af5e9ca2be12a34e5b96985777b46ab4" );document.getElementById("j0f0bb4fb4").setAttribute( "id" Write for us | Advertise with us Global Railway Review is published by: Russell Publishing Ltd.Court LodgeHogtrough HillBrasted © Russell Publishing Limited Website development by e-Motive Media Limited In our vision for the future, the city of Varberg has unique opportunities ideally located with the historic city centre right next to the coastline Our location is exceptional – right in between two of Sweden’s fastest growing regions The Swedish Government makes great investments in the west coast railway to increase the capacity for commuting this means our section of the railway will be located into a tunnel under the city centre To make the most of this we will move parts of our harbour and have begun planning for a new waterfront area that connects the city centre with the coastline we have methods to involve residents living in our more rural communities too We strive to engage people in the decisions that have the greatest effect on their everyday life Through dialogue and local action plans we work together to see where public and commercial service This is becoming ever more important as decision-making is moving farther and farther away from the people New forms of meetings is important for reinventing the community That we have momentum shows in the many awards we get The city of Varberg has been appointed Sweden’s Most Livable in the category of smaller communities for four years in a row now Our thriving city center was recently the winner in Sweden’s City Centre of the Year award it is certainly very fitting that the yearly Varberg event Hallifornia was awarded Placebrander of the year and all the people that have worked so hard to make them possible and regard them as appreciative of our chosen path towards the future Varberg.se the electric truck charging joint venture between Daimler Truck The company is building a new charging hub in southwestern Sweden offering eight charging points in the first phase The first Milence charging hub in a Scandinavian country will be built in Varberg The location is a popular stopover for forwarders and truck drivers and the charging station is strategically located close to the E6 motorway setting up a charging location in Varberg is the first step towards the electrification of transport routes in the Nordic countries the charging hub in Sweden will have eight charging bays and four CCS charging stations showers and toilets will also be available at the site and I am delighted we can now announce the development of our first site in the Nordics,” says Milence CEO Anja van Niersen and all of which are located along key strategic areas and open to all trucks.” has not yet been finalised but has already been announced the joint venture’s charging network is expected to span 15 nations The first MCS chargers will be installed in the company’s charging parks in 2025 milence.com electrive has been following the development of electric mobility with journalistic passion and expertise since 2013 we offer comprehensive coverage of the highest quality — as a central platform for the rapid development of this technology Polish-born Danuta Danielsson was photographed hitting a neo-Nazi with her handbag a myth grew around the "woman with the handbag." Though rumors swirled that she was an elderly Jewish concentration camp survivor Danielsson was only 38 when the photo was taken.  Danielsson's identity came to light in 2014 when a debate started in Växjö over the possibility of commemorating the photo with a statue Both the municipality and Danielsson's son objected Local government didn't want to glorify violence while the son said his mother regretted the photo He didn't want her to be remembered like this.  people started putting handbags on statues to quietly demand that Danielsson be sculpted This was enough to convince artist Susanna Arwin to make the statue and for Swedish hotel entrepreneur Lasse Diding to buy it.  Diding's plan was to install The Woman With the Handbag at Varberg Fortress But the Varberg municipality voted not to display the statue Diding decided to place the statue in the front yard of his villa A second statue of Danielsson in the same pose was unveiled at a public lawn in the city of Alingsås The statue is freely visible from the street This downtown statue pays tribute to the Native American game that gave the city of La Crosse its name This rural park in central Wisconsin honors one of the world’s most prominent numismatists A Portland legend tells of small green archers shooting random passersby with visionary arrows who created the iconic cartoon that features Charlie Brown This statue of an everyday cleaning tool sits proud upon a plinth in Manchester's coolest quarter This pair of statues commemorates a once-widespread carnival tradition of blowing on each other’s butts with bellows A bizarre object of worship believed to grant wishes to those who tie it up with a rope A monument to one of the greatest matadors of all time The municipality’s goal is to plan for a development that is ecologically Development specialization provides a comprehensive picture of the long-term planning approach of the municipality Varberg has great need of new areas for both businesses and residential construction The master plan describes how Varberg planning how in the future we should use our land and water areas On 21 March 2013, the government’s admissibility decisions for projects Varberg tunnel ie reconstruction of the West Coast line to double track through a tunnel under Varberg center This initiates a series of activities aimed at facilitating the implementation of this major government infrastructure projects The project also allows for the commencement of the two projects which the council adopted a intriktningsbeslut about in 2012 namely to transform large parts of the existing port area to allow for urban development and the creation of port operations in the Fare Harbour These projects take top priority and much of urban development should focus on ensuring that the municipality may maximize the potential of the unique opportunity for a sustainable and attractive city that is now available For more information, visit www.varberg.se Save my name, email, and website in this browser for the next time I comment. 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Crossref drive metadata exchange and support nearly 2 billion monthly API queries, facilitating global research communication. 15 Feb 2025 12:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Hammarby vs Varbergs BoIS FC on Sat The current head to head record for the teams are Hammarby 11 win(s) Hammarby haven't lost to Varbergs BoIS FC in their last 6 meetings (6W Have scored 8 goals in their last 5 matches Who won between Hammarby and Varbergs BoIS FC on Sat 15 Feb 2025 12:00:00 GMT?Hammarby vs Varbergs BoIS FC on Sat 15 Feb 2025 12:00:00 GMT ended in a 1–1 tie.InsightsHave scored 7 goals in their last 5 matches Hammarby is playing home against Varbergs BoIS FC on Sat 03 May 2025 13:00:00 GMT?.css-1txiau5-AnswerContainer{color:var(--GlobalColorScheme-Text-secondaryText2);}Varbergs BoIS FC won 1–0 over Helsingborg on Sat Oliver Alfonsi is the competition's top scorer (4) Helsingborg have won the previous 2 matches against Varbergs BoIS FC Who won between Varbergs BoIS FC and Helsingborg on Sat 03 May 2025 13:00:00 GMT?Varbergs BoIS FC won 1–0 over Helsingborg on Sat 03 May 2025 13:00:00 GMT.InsightsHave scored 13 goals in their last 5 matches Varbergs BoIS FC is playing home against Helsingborg on Sat Flying under the radar of those loyal to the familiar major guitar manufacturers Sweden's Strandberg Guitars has quietly built an impressive following featuring some of today's brightest young guitarists Periphery's Misha Mansoor and Scale the Summit's Chris Letchford we're excited to bring you the exclusive premiere of a new 15-minute mini-documentary on the making of Strandberg's new model an instrument resulting from years of research and development master builder Ola Strandberg gives you the full story on the creation of a unique instrument which is based on carefully voiced and matched materials proprietary headless hardware and the brand's EndurNeck technology Also appearing in the video is guitarist Al Mu'min of London's The HAARP Machine who played an integral role in the creation of the Varberg The HAARP Machine will release their debut album For more on Strandberg Guitars, visit strandbergguitars.com Josh HartJosh Hart is a former web producer and staff writer for Guitar World and Guitar Aficionado magazines (2010–2012) He has since pursued writing fiction under various pseudonyms while exploring the technical underpinnings of journalism now serving as a senior software engineer for The Seattle Times “There's something really magical about it”: Bon Jovi's Phil X on why he prefers single-pickup guitars – and his one-of-a-kind neck pickup 'mods' “Smashing Pumpkins taught me that music doesn’t have to fit neatly into a box… it’s not as easy as pie It’s pie with a side of metal!” Billy Corgan asked Jenna Fournier to go back to bass “Makes me feel closer to Pop every time I record”: Wolfgang Van Halen used Eddie’s legendary Frankenstein to track the slap riff – and the wild two-hand tapping sequence – in his new single Permutation loop Permutation loop Permutation Until now, the US production shop has been limited to the Boden series, the CL7, and the Masvidalien. At NAMM this year, Ola announced the forthcoming addition of the Varberg model to the US production line I've been feeding your sick instrument fetishism and trying unsuccessfully to hide my own since 2013 I studied music on both coasts (Berklee and SSU) and now I'm just trying to put my degree to some use You must be logged in to post a comment A one-stop shop for the serious musician. Founded in 2013 Read More // Contact Us // Privacy Policy This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page.