The Daxi Wood Art Ecomuseum (hereafter referred to as the Ecomuseum)is pleased to announce the opening of submissions for the 2nd Daxi International Wood Furniture Craft and Design Competition Entries are welcome from now until February 3 The competition calls on creators worldwide to reimagine the potential of wooden furniture design through the lens of “storage.” This theme highlights the harmonious blend of traditional woodworking craftsmanship and contemporary design innovation celebrating the distinctive aesthetics and functionality of wooden furniture Designers from around the globe are warmly invited to engage in this dynamic and creative journey The competition features two categories: the Open Group and the Youth Group The Grand Prize for the Open Group is set at US$12,000 while the Grand Prize for the Youth Group is US$7,700 with a total of 16 award opportunities available Open to all who are passionate about wooden furniture design the competition invites participants to embark on a journey of creativity and innovation exploring the boundless possibilities of wooden furniture design together boasts a rich woodcraft industry that dates back to the 19th century Daxi's comprehensive woodworking industry encompasses sawmilling The Ecomuseum has been a vital partner in preserving and promoting Daxi's woodworking heritage the Ecomuseum plays a pivotal role in fostering the region's woodcraft culture the Ecomuseum launched the inaugural Daxi International Wood Furniture Craft and Design Competition drawing an impressive 519 entries from 14 countries and regions The competition culminated in 16 exceptional winning designs which were showcased through exhibitions and tours strengthening cultural exchanges between Daxi the Ecomuseum aims to continue hosting this competition creating an international platform for woodcraft creators to exchange ideas and expertise the Ecomuseum seeks to preserve and innovate woodcraft traditions establishing Daxi as a world-renowned hub for woodworking talent “Storage,” reflects the evolving needs of contemporary living spaces and changing lifestyle dynamics Beyond fulfilling the basic function of storing items the competition encourages participants to integrate thoughtful innovations that address spatial dimensions Creators are invited to go beyond traditional frameworks They are also encouraged to experiment with diverse materials blending traditional woodworking techniques with modern design language and creative philosophies bringing warmth and imagination to home living This award/grant/scholarship announcement was submitted by an ArchDaily user. 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Then tune in to the official Pokémon GO Twitch channel on Saturday And what’s a stream without some drops? Snagging Twitch drops during the stream will get you Charged TMs Metrics details The promise of single-objective light-sheet microscopy is to combine the convenience of standard single-objective microscopes with the speed resolution and gentleness of light-sheet microscopes a single-objective light-sheet microscope design based on oblique plane illumination that achieves: (1) a wider field of view and high-resolution imaging via a custom remote focusing objective; (2) fast volumetric imaging over larger volumes without compromising image quality or necessitating tiled acquisition; (3) fuller image coverage for large samples via multi-view imaging and (4) higher throughput multi-well imaging via remote coverslip placement Our instrument achieves a resolution of 450 nm laterally and 2 μm axially over an imaging volume of 3,000 × 800 × 300 μm resolution and versatility of our instrument by imaging various systems including Drosophila egg chamber development zebrafish whole-brain activity and zebrafish embryonic development – up to nine embryos at a time This field of view cannot accommodate large living samples such as developing embryos and fundamentally limits imaging throughput The standard solution to this problem is to tile the acquisition over multiple fields of view multi-view imaging often requires either complex multi-objective configurations that complicate sample mounting or sample rotation that decreases imaging speed the light-sheet excitation and emission pass through a single objective The fluorescence is collected by O1 and relayed downstream with full NA detection The full NA detection is achieved by oblique remote focusing using a bespoke objective with a monolithic glass tip and zero working distance The glass tip compresses the collection half-angle allowing a tilt range from 0 to 55° the stage moves the sample along the scanning axis the galvo mirror moves the light sheet alongside the stage movement during the camera exposure for each image The galvo mirror moves back during the readout time and restarts this compensatory movement during the next exposure Illumination and detection planes remain centered along the entire optical train to give optimal light collection minimal aberrations and thus pristine image quality Our instrument is capable of dual light-sheet excitation This improves illumination coverage and image contrast one of the two light-sheet orientations will have a shorter penetration depth through the sample giving a more contrasted and complete image The dual-view imaging is achieved through an imaging flipping module consisting of two galvo mirrors and three normal mirrors along the optical path (f and g) The illumination light goes along the path highlighted in orange or blue resulting in opposing incident angle at the sample space the fluorescence light goes through either of the two paths resulting in the flipping of the image with respect to that of the other path (blue and orange arrows before and after propagation through the unit) ensuring that the intermediate image is always formed on the front surface of O3 The microscope is converted from upright (dipping right side) by repositioning the coverslip from the focal space of O2 to that of O1 without sacrificing the optical performance The secondary and tertiary objectives are both mounted remotely leaving only the primary objective at the proximity of the sample This configuration makes the optical system effectively a ‘single’ objective light-sheet microscope thus facilitating sample mounting and handling It features an air–glass imaging boundary and a working distance of zero for maximum mechanical clearance and hemispherical collection in air thus allowing our optical system to achieve uncompromised high resolution with a large field of view while simultaneously benefiting from the advantages of high-speed galvo-based scanning Considering the typical exposures and travel speeds needed in practice the only true limiting factors of the scanning speed are camera speed and fluorophore brightness hence effectively flipping the light with respect to the optical axis This image flipping module affects both illumination and detection plane simultaneously so that the imaging plane always falls on the glass surface of the tertiary objective regardless of whether the illumination light goes through the sample from left or right both views share the same downstream and upstream optical path largely simplifying the optical setup and avoiding additional cost The orthogonal image planes will benefit from the contrasting trajectories into the sample in many cases avoiding obstacles and therefore returning complementary information that can be fused in postprocessing Our lens configuration considerably simplifies microscope design and increases its versatility: inverted imaging enables many imaging modalities including multi-well plates and microfluidic devices The optical axis of the microscope is along the z axis (depth) The sample is illuminated by an oblique light sheet in the x’y plane where x’ is the light-sheet propagation direction The field of view in the x’y plane is 800 μm (y) by 420 μm (x’) corresponding to 800 μm (y) by 300 μm (depth Volumetric data were acquired by scanning the sample By using light-sheet stabilized stage scanning compared to 300 μm with galvo scanning) is only limited by the stage Representative PSF obtained by imaging 100-nm green fluorescence beads The PSF is slightly tilted and its long axis (z”) is about 20° with respect to the z axis the line profiles of the PSF were plotted and fitted along the three principal axes 379.2 ± 20.9 and 1,864.9 ± 174.3 nm (mean ± s.d. Images of a zebrafish larvae (roughly 30 hpf nuclei labeled with tg(h2afva:h2afva-mCherry) imaged using the microscope Imaging volume (x,y,z) is 3,000 × 800 × 300 μm acquired every 50 s (two views) where blue and red indicate respectively close to and far from the coverglass Four xy slices from different regions (1–4 dashed squares in a) at various depths and one xz slice (5 Nuclei of germline cells (large) and somatic cells (small) were labeled by expressing UAS-NLS-GFP under the control of Usp10-Gal4 (BDSC-76169) Imaging volume is 3,000 × 800 × 180 μm acquired every 30 s (single views) for 3 h Four regions (dashed squares in c) are highlighted Axial maximum projection showing the whole zebrafish larva tail at 24 hpf nuclei labeled with tg(h2afva:h2afva-mCherry) Imaging volume is 1,064 × 532 × 287 μm consisting of 4,000 × 2,000 × 360 voxels per view for a total of 5.7 billion voxels acquired every 40 s Side projection illustrating how the two light-sheets enter the sample at 45° to reach a given point in the sample Depending on the sample geometry and placement one of the two light-sheets will have a shorter path to reach that point and hence be less susceptible to absorption the corresponding view’s image will be more complete and better contrasted Example regions (single xy plane slices) that demonstrate the complementarity of the two views In some regions (left) the first view has better image quality whereas in other regions (right) the second view is better the two views can be fused together to obtain one high-quality image Time-lapse max-projection frames over a 2.2 h period centered on the dorsomedial tail during which time the boundary between neighboring somites are accentuated Spatio-temporal zoom centered around a cell division both views are acquired every 40 s making it possible to follow the intermediate steps during mitosis—an important capability for achieving a, Top and side views of nine zebrafish embryos mounted in 0.1% agarose gel. b, The embryos (only eight are shown) were imaged sequentially (at 4.5 min per round) for up to 8 h. Only the final frames at t = 8 h imaging are shown (see also Supplementary Video 6 for the time lapse of all nine embryos) The images are maximum intensity projection Five time points from three different fish are shown illustrating the imaging reproducibility across multiple samples 50 μm (top right) and 200 μm (bottom left) light is lost due to the beam-splitter needed for recombining both paths and the mechanical scanning of the mirrors lowers the switching speed Our approach has the advantages of high switching speed uncompromised light efficiency and modularity as it can be added to other microscopes We demonstrate the capabilities of our microscope by imaging large samples including zebrafish larvae and Drosophila fly egg chambers low phototoxicity of light-sheet illumination and high spatio-temporal resolution of the microscope design allow us to image zebrafish embryo development for 8 h at 30-s time intervals these features will allow investigators to precisely follow cell fate and lineages with improved accuracy pushing the limit of imaging to enable the capture of complex cellular choreography during early embryonic development Augmenting our system with a microfluidics sample mounting system would enable large-scale screens of mutants or drug-treated animals this reduces the duty cycle of the excitation which could restrict its suitability for long-term live-sample imaging and for which the high spatio-temporal resolution and large imaging volume would prove to be critical including smart microscopy and data processing with machine learning will further improve the optical performance of the system the versatility and ease of use of the microscope and the data processing efficiency and quality The fluorescence is filtered by either individual bandpass filters (Chroma ET525/50 ET605/70) or a quad-band filter (Chroma ZET405/488/561/640) and then detected by a scientific complementary metal-oxide semiconductor (sCMOS) camera (Hamamatsu ORCAFlash 4.0) The pixel size of the cameras at the sample space is 146 nm (TL7—Thorlabs AC300A) for PSF calibration and 265 nm (TL7—Thorlabs TTL165-A) or 440 nm (TL7—Thorlabs TTL100-A) for imaging so as to capture the desired field of view Objective O3 is mounted on a piezo stage (PI Fast PIFOC Z-Drive PD72Z1SAQ) so that its focus can be finely adjusted Two switching galvo mirrors are used to create two views of the object in the sample space By adjusting the angles of the two galvo mirrors the light is reflected either by just one or by two reflective mirrors The operating principle is similar to that of a Dove prism the switching module also changes the incident angle of the light sheet between +45° and −45° since the excitation light also passes through this module 6SD12205) is conjugated to the pupil planes of both O1 and O2 Rotating the galvometer actuated mirror scans the oblique light sheet across the sample (along the x axis) The galvo mirror also descans the intermediate image at the focal space of O2 so that the intermediate image is always projected at the focal plane of O3 Using the galvometer for 3D scanning allows for faster imaging compared to stage scanning but at the cost of a limited scan range of approximately 300 µm A motorized stage (ASI MS-2000) is used to position the sample and to perform scanning for volumetric imaging stage scanning is combined with galvo descanning to stabilize the imaging plane (coplanar light sheet and detection planes) relative to the sample In the absence of relative motion between the sample and the imaging plane Stabilized light-sheet stage scanning allows for much longer ranges compared to galvometer-based scanning It is only limited by the range of travel of the stage Illumination and detection planes remain fixed and optimally placed at the center of O1 and O2 native axes thus guaranteeing optimal light collection minimal aberrations and thus optimal image quality The microscope’s PSF was measured using 100-nm green fluorescence beads The beads are first embedded in agarose gel (0.5%) and then deposited on a glass coverslip (no The resulting images are then deskewed to the objective-aligned frame of reference (xyz coordinates) The positions of the beads are then detected using by finding the local maxima and a cropped image of each bead is used for further analysis To account for the tilted PSF with respect to the z axis the cropped images are rotated in the xz plane so that the long axis of the PSF (z” axis) is along the z axis The PSFs are then fitted with a one-dimensional Gaussian function along all three axes (x” The values of the FWHM are then averaged from all fluorescence beads in the imaging volume using the other mirror of the two-axis galvo The water dispenser is controlled by another Python module to supply water to the primary objective during long-term recordings The magnitude of the Sobel gradient was used as the metric to generate a blend map Other fusion methods such as frequency domain fusion (discrete cosine transform fast Fourier transform) are available in dexp An illumination intensity correction is applied to the fused data to account for the Gaussian profile of the light sheet along the y axis Each raw data per time point is around 8 GB (two views An 8-hour continuous imaging session produces roughly 8 TB of raw data (roughly 1,000 time points) It takes roughly 1 min to process the data per time point per GPU and 4 h to process the whole dataset with four GPUs running in parallel they are temporally stabilized to compensate minor drifts over time For the calcium imaging experiment fish were embedded in 2% agarose (Sigma A0701) and anesthetized in an external solution with tricaine (0.2 mg ml−1) at 5 dpf melanogaster ovaries were removed from females 3 d after eclosion for observation Fly stocks Usp10-Gal4 (BDSC-76169) and UAS-GFP.nls (BDSC-4776) were used The egg chambers were then transferred to a glass-bottomed petri dish for imaging The mounting was similar to that used for the zebrafish imaging except that the egg chambers were immersed in imaging media (Schneider’s media supplied with 200 μg ml−1 insulin pH 6.95–7.0.) rather than agarose solution Imaging conditions for all experiments can be found at Supplementary Table 6 Further information on research design is available in the Nature Research Reporting Summary linked to this article A sample data of early zebrafish embryonic development, which is useful for testing the dexp processing software, can be found at github.com/royerlab/dexp. Source data are provided with this paper All code can be found at github.com/royerlab/daxi These include the Python code for optical simulation device control and the Micro-Manager acquisition script Our image processing tool dexp can be found at github.com/royerlab/dexp Optical sectioning deep inside live embryos by selective plane illumination microscopy Reconstruction of zebrafish early embryonic development by scanned light sheet microscopy McDole, K. et al. In toto imaging and reconstruction of post-implantation mouse development at the single-cell level. Cell https://doi.org/10.1016/j.cell.2018.09.031 (2018) Multi-scale imaging and analysis identify pan-embryo cell dynamics of germlayer formation in zebrafish Open-top selective plane illumination microscope for conventionally mounted specimens Inverted light-sheet microscope for imaging mouse pre-implantation development Light-sheet microscopy for slide-free non-destructive pathology of large clinical specimens Open-top axially swept light-sheet microscopy 3D high- and super-resolution imaging using single-objective SPIM Optically sectioned imaging by oblique plane microscopy Swept confocally-aligned planar excitation (SCAPE) microscopy for high-speed volumetric imaging of behaving organisms Time-lapse 3-D measurements of a glucose biosensor in multicellular spheroids by light sheet fluorescence microscopy in commercial 96-well plates Epi-illumination SPIM for volumetric imaging with high spatial-temporal resolution High NA single-objective lightsheet (GitHub A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics Quantitative high-speed imaging of entire developing embryos with simultaneous multiview light-sheet microscopy Multiview light-sheet microscope for rapid in toto imaging Efficient Bayesian-based multiview deconvolution Adaptive light-sheet microscopy for long-term high-resolution imaging in living organisms Aberration-free optical refocusing in high numerical aperture microscopy Real-time volumetric microscopy of in vivo dynamics and large-scale samples with SCAPE 2.0 processing and analysis of vascular growth in zebrafish Integrated one- and two-photon scanned oblique plane illumination (SOPi) microscopy for rapid volumetric imaging Tilt-invariant scanned oblique plane illumination microscopy for large-scale volumetric imaging Oblique-plane single-molecule localization microscopy for tissues and small intact animals Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms Adaptive optical microscopy: the ongoing quest for a perfect image Spatially isotropic four-dimensional imaging with dual-view plane illumination microscopy Guo, M. et al. Rapid image deconvolution and multiview fusion for optical microscopy. Nat. Biotechnol. https://doi.org/10.1038/s41587-020-0560-x (2020) Light-sheet microscopy of cleared tissues with isotropic Multi-immersion open-top light-sheet microscope for high-throughput imaging of cleared tissues An optical technique for remote focusing in microscopy Extended-resolution structured illumination imaging of endocytic and cytoskeletal dynamics Universal light-sheet generation with field synthesis Deconvolution-free subcellular imaging with axially swept light sheet microscopy Advanced methods of microscope control using μManager software Pycro-Manager: open-source software for customized and reproducible microscope control Sofroniew, N. et al. napari/napari: 0.3.7rc3. Zenodo https://doi.org/10.5281/zenodo.4012782 (2020) CuPy: a NumPy-compatible library for NVIDIA GPU calculations In 31st Conference on Neural Information Processing Systems (NIPS Dask: parallel computation with blocked algorithms and task scheduling in Proceedings of the 14th Python in Science Conference Vol Miles, A. et al. zarr-developers/zarr-python: v2.4.0. Zenodo https://doi.org/10.5281/zenodo.3773450 (2020) Network flow integer programming to track elliptical cells in time-lapse sequences Deep high-resolution representation learning for visual recognition Yeh, L.-H. et al. uPTI: uniaxial permittivity tensor imaging of intrinsic density and anisotropy. Preprint at biorXiv https://www.biorxiv.org/content/10.1101/2020.12.15.422951v2 (2021) Glia accumulate evidence that actions are futile and suppress unsuccessful behavior A protocol for culturing Drosophila melanogaster stage 9 egg chambers for live imaging Download references We thank the Bioengineering team at the Chan Zuckerberg Biohub for loaning us the water-immersion micro dispenser Sturrman from UCSF for his help on Micro-Manager and J Huisken (Morgridge Institute for Research) for sharing the Tg(h2afva:h2afva-mch) line Wong for diligent proofreading of the manuscript Funding for this work was provided by the Chan Zuckerberg Biohub We thank Calico Life Sciences LLC for funding the development of the AMS-AGY V2.0 objective and for granting a loaned objective We thank the National Institutes of Health (grant no Daniels from Applied Scientific Instrumentation on-stage scanning using the motorized stage The Walter and Eliza Hall Institute of Medical Research University of Texas Southwestern Medical Center designed and built the microscope and performed all imaging wrote the control software with help from A.C.S designed the image flipper for dual-view imaging prepared the Drosophila fly samples with guidance from T.B.K provided the zebrafish samples for brain imaging designed and built the environment chamber wrote the paper with input from all authors A patent application has been filed by B.Y The remaining authors declare no competing interests reviewer(s) for their contribution to the peer review of this work Rita Strack was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Objectives lenses: O1 - Olympus XLUMPLFLN 20XW TL5 and TL6 - 135 mm custom designed tube lens (using off-the-shelf pieces from Thorlabs Scanning galvo and switching galvos: Cambridge 6SD12205 20 mm galvo mirrors Dichroic mirror: DM - Chroma ZT405/488/561/640rpcv2-UF3 2-axes galvo: Cambridge 6SD12056 10 mm galvo mirrors The two switching galvo mirrors can switch the light path so that light is reflected either by M5 and M7 or by M6 only The red arrow is reflected four times along the path and maintains upright while the green arrow is reflected only three times and becomes inverted (c) Dual view images of a calibration grid (Thorlabs R1L1S1P) The two images are clearly flipped with respect to each other The images were taken under bright field illumination and with O3 TL7 and the camera on a straight line with O2 During the acquisition of a 3D image stack and the galvanometer scanner performs a counteracting motion of the light-sheet and detection planes to cancel out any relative motion between sample and imaging plane (which in our design is always coplanar with the light-sheet illumination) resulting in an effective step-wise scan of the sample one can reposition the coverslip at the focal space of O2 to that of O1 as shown in (c) and can still achieve similar optical performance turning the system to an inverted configuration (d) shows a representative PSF of such a system (c) The average FWHMs are respectively 382.2 + - 8.9 nm (x) The numbers are indeed similar to that of the top configuration (a) The objective front lens is parallel to the xy plane where x’ is the light sheet propagation direction and its long axis (z”) is about 20° with respect to the z-axis The line profiles of the PSF were plotted and fitted along the three principal axes (x” Source data The larvae is imaged at 2 dpf. The nuclei (magenta) are labelled with tg(h2afva:h2afva-mCherry). The membranes (cyan) are stained using Vybrant DiO cell-labeling solution (Thermal fisher V22889) Dio injections for retrograde live label was applied at 24 hpf followed by an O/N incubation at 29 C incubator before imaging (b) Representative xy slice of the 3D data (c) Magnified view of the region highlighted in the white dashed rectangle in (b) High-resolution images are recorded in steps of 8 μm with an exposure time of 8 ms The recording of two different zebrafish lines is shown in (a)-(c) and (d)-(f) (a) and (d) show the max intensity projection of the 3D volumes (b) and (e) show regions of interest from a single slice of the 3D stack indicated by the write rectangles in (a) and (d) (c) and (f) give representative fluorescence signal of five different neurons over time (a) show the orientation of the embryo mounted on the sample stage with the head facing the primary objective (O1) (b) 3D rendering of the zebrafish brain images (c) XY slices of the brain images at different depths up to 167.4 mm rerio (zebrafish) embryo at 30 hpf imaged on DaXi melanogaster (fly) egg chambers 3 d after eclosion Acquisition lasted for 2.5 h with an acquisition interval of 27 s for a total 342 time points rerio (zebrafish) embryo starting at roughly 10 hpf and ending at 18 hpf Acquisition lasted 9 h with a 30-s acquisition interval for a total of 1,079 time points rerio (zebrafish) embryo starting at roughly 24 hpf and ending at 32 hpf Acquisition lasted 8 h with 73-s acquisition interval for a total of 390 time points nuclei segmentation and cell tracking of a D rerio (zebrafish) embryo starting at roughly 12 hpf and ending at roughly 18 hpf Acquisition lasted 6.6 h with 30-s acquisition interval for a total of 791 time points rerio (Zebrafish) embryos starting at roughly 10 hpf and ending at roughly 16 hpf Acquisition lasted 4.6 h with 167.5 s per fish per stack for a total of 100 time points nuclei segmentation and cell tracking of nine D Video abstract illustrating the main concepts behind DaXi: (1) the sample mounting advantages of single-objective light-sheet microscopy for high-throughput imaging (2) an explanation of stabilized light-sheet scanning (LS3) (3) multi-view imaging for improved coverage (4) uncompromised resolution with the AMS-AGY v.2.0 ‘Snouty’ custom objective (5) high-fidelity 3D rendering of the whole microscope and optics setup and (6) the innovations (animation and rendering by L.W Download citation DOI: https://doi.org/10.1038/s41592-022-01417-2 Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. 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Volume 11 - 2023 | https://doi.org/10.3389/feart.2023.1348730 Against the backdrop of global climate warming the issue of flash flood disasters in small watersheds triggered by heavy rainfall is gradually becoming more prominent Selecting an appropriate hydrological model is crucial for flash flood disaster defense This article focuses on the Daxi Water Basin in Lianping County organize the data and subject it to standardization processing establish the topological relationships within the basin construct a hydrological model for simulating flood processes in Chinese mountainous regions and obtain a set of model parameters applicable to the specific basin The results indicated that: ① the relative errors of flood runoff depth were all less than 7% with an average of 4.5%; ② the relative errors of peak flow for all events were less than 6% with an average of 4.2%; ③ peak time errors were all within ±2 h either earlier or later than the actual peak by 1 h; ④ the Nash-Sutcliffe efficiency coefficient for floods were all greater than 0.8 The research results above will serve as a reference and guidance for flood defense management in the Daxi Water Basin research on flash flood prevention is a focus issue that has attracted much attention at home and abroad Lumped hydrological models treat watersheds of various scales as a homogeneous entity typically neglecting spatial variations in natural geographical elements and hydrological processes within the watershed they struggle to describe the internal hydrological processes of the watershed distributed hydrological models consider differences in rainfall and underlying surface conditions across the watershed allowing for a more realistic representation of the actual hydrological processes within the watershed selecting a hydrological model that suits the characteristics of the watershed is crucial for effective flood defense in hilly regions providing insights into the use of GWRR data sources for hydrological modeling in data-scarce regions validating the applicability of the SWAT model in data-scarce and complex mountainous watershed areas The Daxi Water Basin in this study is prone to flash floods and there is currently limited research on flood simulation in this area By introducing the Chinese Flash Flood Hydrological Model a set of characteristic parameters suitable for this basin was calibrated and validated Combined with multiple evaluation indicators This research aims to provide reference and guidance for mountainous flood defense and control in the studied watershed The river network system and rainfall-flood monitoring stations in the Daxi Water Basin are concentrated in the eastern Shangping watershed. Therefore, this paper designated the Shangping watershed as the primary study area (Figure 1) The basin is situated in the northeastern part of Lianping County The total area of the basin is 175.95 km2 with the outlet of the basin located at approximately 114.57°E and 24.44°N The basin spans from the northeast to the southwest with the terrain rising in the north and lowering in the south The northern-central part features undulating mountain ranges belonging to a segment of the Jiulian Mountain Range in Guangdong Province The valleys between the mountains are deeply cut by flowing water developing into narrow and deep "V"-shaped valleys shaped by river erosion and crustal uplift give rise to relatively smaller "V"-shaped valleys on their side slopes—hanging valleys The southwestern part is characterized by low hills The research area experiences a subtropical monsoon climate characterized by simultaneous high temperatures and rainfall during the rainy season with the peak concentrated in May and June Summer is susceptible to heavy rainfall due to convective thunderstorms and typhoon influences The Daxi Water Basin is one of the six main rivers in Lianping County with a total of 15 major and minor tributaries The river originates from the Jiaofeng Ridge (elevation 732.9 m) in Zhongcun The river has a total length of 75 km and an average annual runoff of 15.95 m³/s (1) Chinese Flash Flood Hydrological Model China flash flood hydrological model structure diagram The Shangping Watershed comprises 14 sub-watersheds with sizes ranging from 0.4 km2 to 29.03 km2 there are five rainfall observation stations and two hydrological observation stations Taking into account the characteristic of the watershed’s terrain being higher in the north and lower in the south the downstream Shangping hydrological station was designated as the outlet node and the watershed’s topological structure was established Given that the Shangping Watershed is located in a humid region the runoff module primarily employed the Xin’anjiang three-source storage runoff method The convergence module utilized distributed unit hydrographs extracted and processed from the "National Mountain Flood Disaster Prevention Project" (1) which effectively reflects the phase-based impact of underlying surface and rainfall intensity on flow velocity in various river sections The river channel evolution module employed the dynamic Muskingum method (2) suitable for small watersheds with limited data availability In the equation: V represents the flood flow velocity measured in meters per second (m/s); Ks is the coefficient used to calculate water flow velocity measured in meters per second (m/s); S is the specific drop of the river bed in any grid in the basin; i is the dimensionless rain intensity; Tj is the time required for runoff convergence in the j-th grid of the watershed; Mj is the number of grids passed through by runoff convergence in the j-th grid of the watershed; Vm is the flow velocity in the mth grid of the watershed measured in meters per second (m/s); L m is the length of the river channel passed through by the flood when it traverses the m-th grid; c is the coefficient In the equation: K represents the slope of the reservoir storage curve in terms of elevation (h); Q0 is the reference flow rate measured in cubic meters per second (m³/s) calculated as Q0 = Qb + 0.5(Qp - Qb) where Qb is the maximum upstream flood flow rate and Qp is the maximum upstream flood flow rate both measured in cubic meters per second (m³/s); Vm is the wave velocity measured in meters per second (m/s); x is the flow ratio coefficient; J is the channel slope; L is the length of the channel measured in meters (m); N is the Manning’s coefficient Parameters a and b are determined based on the cross-sectional shape Calculation formula of evaluation indicators Ts,p are the simulated average runoff depth (mm) and the simulated peak current (h) respectively; Qs,i is the simulated flow rate at the time i T0,p are the measured average runoff depth (mm) the measured peak flow rate (m³/s) and the actual peak time (h) respectively; Qo,i is the measured flow rate at time i ‾Q0,i is the average measured flow rate The flood event "20190305″ exhibits a double-peak pattern with an initial flow smaller than other events The first peak flow occurred at 22:00 on March 5th differing from the actual peak flow by 3.2 m³/s The rise in flow during the second phase was slower and the relationship between post-peak flow and time became more linear The period with significantly higher flow concentrations for the entire flood event occurred from 13:00 on March 5th to 08:00 on March 10th with good fitting between simulated and actual flow processes during this period The flood event "20190413″ is a typical double-peak flood The simulated peak flows occurred at 22:00 on April 13th and 21:00 on April 14th The measured peak flows occurred at 21:00 on April 13th and 20:00 on April 14th the intervals between the simulated and measured peak flows were both 23 h the river channel base flow was relatively high during this flood and the rainfall continuity was not strong resulting in a relatively gentle fluctuation of the entire flood The flood event "20190419″ is a multi-peak flood Intense rainfall from 19:00 on April 18th to 10:00 on April 19th caused frequent changes in rainfall intensity leading to significant fluctuations in flood flow along with the rainfall trend Three peak flow values occurred during this period: 56 m³/s at 21:00 on April 18th 60 m³/s at 01:00 on April 19th and the highest flow value of 83 m³/s at 06:00 on April 19th The flood event "20190427″ had a slightly higher base flow than other events with the first peak occurring in the second hour (15:00 on April 26th) the short duration of rainfall led to a sudden drop in flood flow A second round of rainfall occurred at 00:00 on April 27th resulting in the second peak flow of this event at 79 m³/s The third intense rainfall occurred at 13:00 on April 27th and although the third peak flow was slightly lower than the previous two the high flow period lasted for 7 h The flood event "20190522″ had a shorter duration compared to others with the first peak occurring at 12:00 on May 22nd a second peak flow occurred at 22:00 on the same day Due to the discontinuous nature of rainfall the fitting degree between the simulated and actual flood processes for this event was smaller than for other events the routing of the five flood events show strong consistency with the changes in rainfall during the study period all five flood events exhibited significant flow fluctuations before the main peak and the decrease in flow during the declining phase after reaching the maximum value was slow the simulated flow results of the three flood events with more continuous rainfall "20190305," "20190419," and "20190427," were closer to the measured flow values indicating better overall simulation performance From the statistical results of flood simulation errors (refer to Table 3) it can be observed that all five simulated flood events are qualified: The relative errors in flood runoff depth for all five events were below the maximum permissible error of 10%; the maximum error was 6.1% for the "20190522″ event while the minimum was 2.4% for the "20190305″ event Relative errors in peak flow were below the maximum permissible error of 20% for all five events accounting for 100%; the maximum error is 5.4% Four events simulated peak times occurring 1 h later than the observed peaks the simulated peak occurred 1 h earlier than the observed peak; the simulated results were within the maximum permissible error of ±2 h Nash-Sutcliffe efficiency coefficients for all five events were above 0.8; the maximum was 0.91 for the "20190419″ event the minimum was 0.81 for the "20190522″ flood indicating a good correlation between the simulated and actual flood processes Comparing the analysis of the five flood events although all error values were within permissible ranges and the fitting degree between the simulated and actual flow processes was not high both relative errors in runoff depth and peak flow were the lowest and the Nash-Sutcliffe efficiency coefficient was closest to 1 making it the event with the best simulation performance The China Flash Flood Model can accurately simulate the flood processes in the Shangping River basin conducted flood simulations in small watersheds within susceptible mountainous flood areas and evaluated the model’s applicability The main conclusions are as follows: ①small watershed river flood processes exhibit strong spatial heterogeneity in which distributed unit hydrograph can effectively reflect the impact of different rainfall intensities and underlying surface conditions on flood velocity in various river segments; ②there is a strong consistency between flood flow and rainfall intensity variations but both lag behind the changes in rainfall; ③the relative errors in simulated runoff depth were all below 7% peak timing differences were within 1 h and Nash-Sutcliffe efficiency coefficients were all above 0.8 and the accuracy was higher for flood events with continuous rainfall This research provides reference for flood forecasting and control in the studied region including a limited number of flash flood events and the need for a more in-depth analysis of the mechanisms responsible for heavy rainfall These issues may affect the operational application of the model and hinder a more comprehensive exploration of flood characteristics the researchers plan to incorporate machine learning techniques to reveal the flash flood mechanisms enhance the model’s informatization and intelligence and provide theoretical and empirical foundations for flash flood simulations in data-scarce regions in China The raw data supporting the conclusion of this article will be made available by the authors The author(s) declare financial support was received for the research This study was supported by National Natural Science Foundation of China (grant number 42101086 and Study on flash flood risk assessment method based on ensemble learning (grant number IWHR-SKL-KF202310) The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Chen, Z. F., and Wei, Y. (2023). Floods in Libya lead to thousands of deaths-how did all of this happen. Pengpai News 2023. Available at: https://www.thepaper.cn/newsDetail_forward_24565310 Google Scholar Application of distributed hydrological model to flood prediction in semi-arid areas CrossRef Full Text | Google Scholar Dong, X. M. (2023). The Ministry of Emergency Management released the national natural disaster situation in the first three quarters of 2023. Yangtze River cloud press, 2023–2110. 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Meihong Ma, bWFtaEB0am51LmVkdS5jbg== †These authors share first authorship Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher. 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish. "We believe that a long-lasting neuromodulator product will fill a significant unmet need in both aesthetics and therapeutics." But before you go book an appointment with your dermatologist you should know that this new neurotoxin is still pending approval from the Food and Drug Administration (FDA) We turned to the experts to learn everything and anything about Daxi before it hits the clinics a board-certified dermatologist at MDCS Dermatology in New York City adds that Daxi blocks the nerve signals that cause muscles to contract "Daxi can help smooth fine lines on the face for a younger-looking appearance," says Bruce Katz a board-certified dermatologist at Juva Skin and Laser Center in New York City who was also one of the first dermatologists to clinically study Daxi explains that it is formulated with a proprietary protein which the toxin that paralyzes the muscle is attached Revance adds that the injection does not contain any human or animal-based components The biotech company tells Allure that it expects people treated with Daxi may achieve frown line corrections all year long with as few as two treatments once approved by the FDA The most striking difference between Daxi and other neuromodulators like Botox is its long-lasting results Garshick explains that studies show that movement in the face return on average around six to seven months as opposed to the average of three months with other neuromodulators he's noticed patients experience even better skin results than those who used other neurotoxins there is a line of demarcation that shows you where the treatment ends relative to the surrounding areas," he says "Daxi seems to have a smoother transition from the treated area to the untreated area." If you've already had Botox or other neuromodulator treatments, then you can pretty much expect the same possible side effects, such as mild bruising and drooping eyelids or brows Katz adds that some people have reported getting headaches after treatment but these cases are rare and the headaches ultimately go away He advises that those with nerve disorders in the face, like multiple sclerosis (MS) but otherwise deems it safe for most people to use Garshick adds that it might not be the best option for those who just want to test out how facial injections look and feel as the effects last longer than Botox and other neurotoxins "For those who are just trying out neuromodulators for the first time, a longer duration of action may not be ideal if you just want to see how you like it," she says. "Similarly, if you experience any side effects, such as an eyelid droop also known as ptosis it theoretically may take longer for the side effects to subside." Shafer stress the importance of going to a provider who specializes in these aesthetic injections to minimize the risk of negative side effects the emergence of Daxi and other products [makes] it's more important than ever for patients to make sure their provider is well trained and transparent in which product they are using to treat their patients," says Dr "Daxi paralyzes the muscle and prevents movement there is the risk of ending up with a drooping eyelid or eyebrow," adds Dr "It's important to go to a practitioner who is versed in administering neurotoxins to ensure correct placement." More info about common cosmetic procedures: Now, check out what's in Allure's April new member box: Revance presents 4 AAD VMX ePoster abstracts examining phase 3 study data for DAXI and the impact of HA filler manufacturing technologies on HA chain degradation recently announced the presentation of 4 ePoster abstracts shown at the American Academy of Dermatology Virtual Meeting Experience (AAD VMX) from April 23-25 3 highlighted SAKURA phase 3 study data on the company’s investigational daxibotulinumtoxinA (DAXI) for injection of glabellar lines (GL) The findings included the elimination of GL with DAXI through a novel graphical representation of the entire distribution of GL severity ratings and changing scores used to depict patterns of efficacy over time.1  The pooled data revealed that 80% of DAXI-treated subjects were rated as “none” at Week 4 68% and 24% were also rated as “none” at both Weeks 4 and 12 This represents a 3-point improvement from baseline with 90% of all subjects achieving a ≥2-point improvement from baseline to Week 4.1 The second poster examined data from a subgroup analysis of the efficacy and safety of DAXI injections among adult women across multiple SAKURA phase 3 age cohorts.2  The proportion of subjects who achieved none or mild GL per investigator at Week 4 were: 97.2% (18-45 year old’s) The third poster showcased results from an evaluation of how repeated DAXI use could affect the progression of static/resting GL.3 “DAXI-treated subjects showed substantial and progressive improvement in static GL with repeated treatment,” wrote the study authors.3 “The extended duration of therapeutic benefit observed with DAXI in dynamic GL provides a longer window of muscle hypoactivity permitting an extended period for dermal remodeling to occur This can potentially account for the progressive improvement in static GL observed over repeated DAXI treatments.” Revance also presented a poster on the impact of hyaluronic acid (HA) filler manufacturing technologies on HA chain degradation.4 Soluble HA (sHA) fraction chain length was examined along with the distribution in commercial filler products Using 13 US-marketed fillers from 5 manufacturing technologies Size Exclusion Chromatography (SEC) examined the mean molecular weight of sHA released from the final formulation per syringe “Preserved Network Technology (PNT) fillers released the longest sHA fragment chains (~500-600 kDa) Vycross fillers released the shortest sHA fragment chains (~100-165 kDa) PNT released the lowest amount of sHA compared to other technologies for all 3 low [molecular weight] fragment size categories with 0% in the <30 kDa category Vycross released more of the shortest sHA fragment chains for all 3 low [molecular weight] categories,” wrote the study authors.4  Investigators concluded that most products using high molecular weight HA undergo significant HA chain degradation during the manufacturing process “These data continue to underscore the innovation that drives Revance’s aesthetics portfolio including our investigational neuromodulator product which was launched in September 2020,” said Roman Rubio senior vice president of clinical development at Revance in a press release announcing the posters.5 Subscribe to Dermatology Times for weekly updates on therapies OCT and D-OCT Imaging Reveal Distinct Vascular and Dermal Patterns in Skin Photoaging Phenotypes The Cutaneous Connection: Using the Color Wheel to Discuss Nutrition Novel Microneedle Radiofrequency Device is Safe for Horizontal Neck Wrinkles The Cutaneous Connection: Cosmetic Dermatology: Procedures and Practice AbbVie Files BLA for TrenibotE in Glabellar Lines Exclusive: Outgoing AAD President Seemal Desai, MD, FAAD, on the 3 Issues That Will Shape Dermatology in 2025 (& Beyond) 609-716-7777 Diana Kuan These spots are worth making an effort or crossing town for by | Apr 17, 2015 | The Oracles Library But even as someone who grew up in Daxi (大溪) I had a hard time appreciating what exactly was so magical about my hometown That was the question on my mind when I joined a day trip to Daxi organized by my friend Alysa Chiu who leads a small group of volunteers working on cultural revival in the Taoyuan region Daxi is a small town tucked away along the upper reaches of the Dahan River at the crossroads between the plains to the west you will pass Sanxia before reaching the ports of Dadaocheng and Tamsui in Taipei Southward will take you to Longtan and Beipu important Hakka settlements along the foothills of northwestern Taiwan and you’ll immediately be in indigenous Atayal lands My house was a rather typical row house in an alleyway The traditional street market was a 10 minute walk away and my elementary school was on the other side of a pedestrian bridge While I don’t remember frolicking in the rice fields as a kid I do remember things like a particular eatery with very crunchy fried pork chops and watching American TV shows like MacGuyver on Saturday nights my life had very little to do with the grand histories or traditions of Daxi my father would take me to “hike” an old mountain trail near my home it was a short but steep descent down to the riverbanks I knew the trail was old—it passes by a bunker that was used as shelter from American B-2 bombings during World War II a 100 year old irrigation channel that actually tunnels through the mountains shaded by the overgrowth of palms and ferns I traded the lush hills of Daxi for the skyscrapers of New York It was not until another ten years before I returned and started rediscovering Taiwan for myself I continued to visit Taiwan about once a year and stayed in Daxi at night while hanging out with my friends in Taipei during the day Daxi was nothing but a sleepy little town—“make sure you come home by 8 o’clock or there will be no place open for dinner.” The place with the crunchy pork chop rice had closed shop many years ago But something about the place still pulls at me and Alysa and I decided to take a group of friends to Daxi for a visit it was not just to “show my friends around town.” It was an opportunity to see my own past through the eyes of others I arrived early at the Taoyuan High Speed Rail Station It was only my second time there; it of course did not exist when I was small I sat in the Mos Burger shop inside the station and my late grandfather’s favorite hymn “What a Friend We Have in Jesus” plays softly in the background Looking outside the floor to ceiling glass window and rows after rows of ads for new developments First impression: this was not even my own past but it felt more like traveling somewhere new still proudly displaying their intricate baroque stonework We spent some time just relaxing in the old Gu residence one of such shop-houses that had seen many uses and is now being renovated as a cultural site We saw what was left of the Japanese-built Daxi Shrine–a base and a utilitarian “observation deck” built over it something that probably came straight of out of Big Brother’s playbook We took pictures of statues of Chiang Kai-shek the Republic of China’s long serving Generalissimo We toured an old tea factory in the mountains that now also serves tea and other dishes for the crowd of tourists that come in Which brings me to what I really saw that day: tourists When I saw the double-decker buses with their neon rainbow paint and the happy faces of people eating street snacks and taking selfies everywhere I am glad that there exists commercial incentives to keep unearthing and preserving our heritage even those reminders will soon be thrown in the trash But if all that is left right now is to take marketable reminders of our heritage and put them on display for others those reminders themselves will be what is left of our heritage The Daxi seen by the tourists was to me a foreign country bearing little resemblance to the Daxi that was mine I was a tourist in my own hometown—more precisely But aside from being a tourist spot with beautiful views and a rich history In a world where everyone is hand-cuffed to each other through the global supply chain what are Daxi’s marching orders in the worldwide division of labor I believe the Daxi that was mine is still alive and well There is a ten-year-old child living in Daxi right now she will have her own life markers to remember Daxi by She may very well leave Daxi for a big city but she will always be proud of being from Daxi Not just because Daxi is known for making tasty tofu but because Daxi’s life markers were responsible for teaching her the first lessons about the world I would drive our own crew of tourists back to the train station As we patiently waited in the clogged traffic leaving town Nothing magical about it; in fact it was gaudy to the extreme was the secret entrance to the old mountain trail “Daxi is a magical place,” someone whispered to me (Feature photo of tea served at Lovely Taiwan in Daxi Terms of Service | Contact Us © 2013 – 2021 Ketagalan Media Robert Sietsema awards four stars to the Flushing newcomer Oohs and aahs went up as the waiter wearing a red neckerchief bore a bamboo bird cage across the room It was decorated with bright plastic flowers and he set it down on our table with a flourish He opened the cage door and inside were nearly a dozen pork ribs neatly stacked But these were not just any pork ribs: Each was compressed inside a sausage casing giving them an eerily smooth and shiny appearance The flesh was smoky and delicately flavored with cumin Sichuan food — or at least a pallid version of it — has been around New York at least since the 60s when it achieved popularity on the Upper West Side and in Chinatown with peppercorn-laden dishes that were spicier and altogether closer to those served in the Sichuan province in southwestern China Chains like Wu Liang Ye and Grand Sichuan broadcast the cuisine throughout Midtown to Greenwich Village and even all the way to Bay Ridge Now a new phase in the development of Sichuan food is underway more expensive places catering mainly to Chinese customers are popping up in Flushing Not content with earlier versions of the cuisine and its collection of recognizable dishes these menus explore Sichuan cooking as never before: including up-to-the-minute innovations occurring contemporarily in Sichuan restaurants in China Related to a 35-year-old restaurant in Chengdu according to our hostess it recently opened on the second floor of the New World Mall near the Flushing subway station A line of easy chairs outside allow you to wait in comfort including monitors that flip photos of scrumptious dishes offered inside It recently opened on the second floor of the New World Mall near the Flushing subway station Rows of padded booths line windows that look out on Roosevelt Avenue while less comfortable booths with too-low banquettes run along one wall Dozens of tables fill a central dining area A look at its Yelp will show that it’s filled with complaints — but DaXi is currently producing some of the city’s best Sichuan food The dish described above is called Tibetan-style pork rib ($23.99) It reminds us that Tibetan expats have been streaming into Sichuan province for decades because Tibetan ribs in a birdcage seems like pure invention Other surprises include a bright orange congee made with millet instead of the usual rice Many of the dishes in the six entrée sections — with one outlier price that runs as high as $168.99 for a stir-fried tiger grouper — have visual gimmicks perfectly cooked shrimp coated with a semi-sweet soy sauce tumbling out of a box of fried rice paper with a few raw cashews scattered on top The cold appetizer of peeled and crushed cucumbers gobbed with garlic has become a standard in modern Chinese restaurants But what is the best part of the cuke when it comes to crunch DaXi reconfigures the dish as curling cucumber skins and calls it “crispy cucumber roll” ($7.99) many judge Sichuan food by its hotness and gravitate toward orders that elicit the numbing endorphin rush provided by multiple forms of spiciness —sometimes all in one dish: red chile oil One of the best and hottest dishes on DaXi’s menu goes by the wordy name of house special sliced fish in hot chile oil ($29.99) The very appearance of what’s inside the broad white bowl may cause you to gasp: Swatches of white fish glint among a vast flotilla of dried red chiles some of the greatest pleasures of DaXi are the simplest and cheapest House special rice and cured meat in the country style ($12.99) is a crock filled with rice dotted with all sorts of meat and fat tidbits and I could have happily eaten it as my entire meal More surprising is corn pancake in Chengdu countryside style which turns out to be clods of steamed cornbread with a wonderfully musty flavor perhaps owing to the cornhusks in which they come wrapped Sample dishes: Sliced fish in hot chile oil What to Drink: Tea and tap water are free; several beers are available tend to be larger than at other Chinese restaurants so bring a group and order fewer dishes than you might otherwise A community celebrating Black voices Beautycon is a global platform that brings together beauty enthusiasts and industry leaders to explore the latest trends and conversations shaping the future of beauty Metrics details A new single-objective light-sheet microscope has been developed that uses novel optics and imaging protocols to increase resolution without compromising imaging speed and volume Prices may be subject to local taxes which are calculated during checkout Seminal paper that presents oblique plane microscopy (OPM) the first demonstration of single-objective light-sheet microscopy with no additional reflecting elements a single-objective light-sheet microscope that allows volumetric imaging of living samples at ultrafast speeds This work solved the long-standing resolution-loss problem in OPM and demonstrated uncompromised spatial resolution for subcellular imaging Millett-Sikking, A. et al. High NA single-objective light-sheet. https://andrewgyork.github.io/high_na_single_objective_lightsheet/ (accessed 28 Jan 2022) An ongoing project that reports the use of a custom glass-tipped objective lens for high-resolution single-objective light-sheet microscopy — a critical step towards widespread adoption subcellular single-objective light-sheet imaging of living specimens mounted in a variety of imaging chambers Download references This is a summary of: Yang, B. et al. DaXi—high-resolution, large imaging volume and multi-view single-objective light-sheet microscopy. Nat. Methods https://doi.org/10.1038/s41592-022-01417-2 (2022) Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41592-022-01420-7 a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science 1143TAIPEI (Taiwan News) — The 2019 Taoyuan Flower Festival's Daxi event kicked off with a ceremony on Sunday (Nov featuring blossoming flowers in a 17-acre field surrounding the Li Teng-fang Mansion The organizer of the annual event, the Taoyuan City Government, has grown various flowers in vast fields of fallow farmland, which it has also decorated with installation art. This year’s flower festival will last from Nov. 9 to Dec. 1 at three exhibition areas across the city, according to a CNA report According to the event’s Facebook page, the Daxi exhibition is taking place in the Yuemei community in Daxi District from Nov The other two venues are in Zhongli and Pingzhen Districts The Zhongli exhibition will take place around Wenxing Rd. and Dongzhi Rd. from Nov. 16 to Nov. 24, while the Pingzhen event will be held in the vicinity of Miaoqian Rd Taoyuan Mayor Cheng Wen-tsan (鄭文燦) said that conditions in the Daxi area where several different agricultural recreational areas are located The mayor added that the city government has held many big events in Daxi including the Taoyuan International Kite Festival and Daxi Bean Curd Festival all of which were well received by visitors He added that he hopes the annual flower festival will be increasingly popular and become an important tourist event for Daxi in the future For more information about the 2019 Taoyuan Flower Festival, please visit its official website. Taiwan Railway to offer public tours aboard 'presidential train car' High speed rail plans free tickets to attract visitors to central and south Taiwan Taipei and Taoyuan MRT to launch joint ticket with Japan’s Keisei railway Taiwan sees 5 million international visitors as of August Tainan plans cable car project in Hu Tou Pei Scenic Area Tourists visit Daylily Mountain in eastern Taiwan Taiwan dollar hits NT$29 per US dollar triggering currency exchange rush Taipei MRT reminds passengers of drinking water ban Magnitude 5.5 earthquake strikes off east Taiwan Vietjet flight makes unscheduled landing in Taiwan Four Vietnamese residents found dead in northern Taiwan Central Bank steps in as Taiwan dollar posts strong single-day gain Taiwan ranked 2nd most innovative country in world Rising Taiwan dollar over Trump tariffs has pros and cons US tech earnings spark Taiwan stock market rally Taiwan ranks 1st in Asia on World Press Freedom Index let's make it clear that I'm a big fan of Botox — huge I've been a regular user for the last six years breaking my streak only at the height of COVID I love how Botox smooths my fine lines and keeps deeper wrinkles from forming but I don't love how quickly it seems to fade as well as the two weeks I often have to wait for it to kick in So when I heard that the FDA had approved Daxxify a new neuromodulator that's supposed to last about twice as long as its competitors the line-smoothing effects of Daxxify — also known as Daxi — lasted an average of six months "it's been a welcome addition to the neuromodulator community," says Dr Ari Hoschander, MD a board-certified plastic surgeon who has started using Daxxify at his New York City practice credits its longevity to the peptides in the formula though he says they don't change the way it delivers the botulinum toxin to the nerve cells to "prevent certain nerve signals from interacting with the specific facial muscles." The addition of peptides does facilitate a better interaction of the treatment with those target nerve cells Each peptide is highly positively charged and therefore binds to the negatively charged core neurotoxin as well as to the negatively charged nerve cell ultimately leading to longer-lasting results Also of note: While Botox is FDA-approved for forehead lines lateral canthal lines (the smile lines around the eyes) so far Daxxify is only FDA-approved for the latter But it's common practice for dermatologists to administer injectables off-label so it's safe to assume that Daxxify is being used on forehead lines and crow's-feet mentioning that she first used it on herself and other office volunteers for firsthand anecdotal data well-established patients with a history of success using other neurotoxins I also used it on people that wanted less mobility for a longer period of time who explains the concentration of toxin in each product is different she's been following the recommended 40-unit protocol when treating patients with Daxi in the between-the-brows region she's been using the same dosage of Daxi as she would with other neuromodulators Both Dr. Marchbein and Hunt say Daxi gives a more glossy, immobile look than Botox or Dysport, which is why it's important to ask patients about their desired result before deciding which product — and how many units — to use. In my case, Hunt swapped back to Botox for my off-label lip flip also citing the aesthetic community's general lack of knowledge about using Daxxify in that area there's no real-world data just yet to back up the claim that Daxi lasts for six to nine months And with some experts telling Allure that they are often injecting less than the dosage used in the Daxi studies (instead of administering the same amount they would of Botox) it's possible patients might experience less than the average six-month longevity found in the studies there is another potential bonus being reported by some early Daxi adopters: It can kick in much sooner than its competitors — in days instead of weeks I noticed that I had slightly less mobility and within 24 hours My left eyebrow tends to move up my face more when I look surprised but it was entirely relaxed by the second day My dose of Daxxify appeared to kick in fully within about three days it would take about 10 to 14 days for me to see the full effects of Botox "I've been very impressed by how quickly Daxi sets in," says Dr "Much faster than any other neuromodulator I've injected with almost-complete effect by 48 hours." Its line-smoothing peers don't reach their full effect for one to two weeks Hoschander says his office has "found that Daxxify took longer to kick in than Dysport and about the same as Botox," adding that it’s still too early to tell definitively The potential side effects of Daxxify are nearly identical to that of Botox — bruising and droopy eyelids with one big difference: They could last longer “That’s why it’s so important to be very selective who your injector is and how much experience they have,” says Dr you could be stuck with them for almost a year rather than a few months — and there’s no way to make it wear off more quickly.”  Another downside to the long-lasting results: the price tag While the price of Daxxify is dependent on everything from geographic location to the injector most people can expect to pay anywhere from 50 to 100 percent more for a unit of Daxxify than for other neuromodulators like Botox (My treatment was performed gratis with the understanding I'd be writing about my experience.) Although depending upon how long Daxxify lasts for you as compared to other neuromodulators you could very well net out even — and save yourself the commitment of several appointments per year "The jury is still out on how effective and how long Daxxify will actually last," says Dr Love echoes that sentiment and mentions the learning curve that comes with gaining real-world experience with a new product were trained on Botox when learning neuromodulators," says Dr who notes that Botox has been FDA-approved and regularly used for two decades "This means that most physicians are more comfortable with Botox some providers may completely change to Daxxify while others will just keep it as an additional tool in their toolbox." Dr Love concludes: "The most important [test of] Daxxify is still to be determined — and that is real-world experience." I can't say if I prefer Daxxify over Botox until I can see if it lasts as long as promised but I will say that so far I'm happy with my results — and how quickly I saw them April 2023: I noticed that my forehead isn't as crinkly as it usually is at this point post-Botox I'm finding the longevity of Daxxify is on par with what I've experienced with Botox Watch a dermatologist's entire routine: Taoyuan is hosting the First Daxi International Wood Furniture Craft and Design Competition with a prize pool of US$49,000(NT$1.5 million) The competition aims to promote Daxi's wood furniture craft encourage diversity and innovation in the industry and raise international awareness of Taiwan's wood furniture Creators from all over the world are welcome to participate The "An Inspired Life with Wood Furniture" competition seeks original submissions from designers interested in creating artistic wood furniture that enhances daily life and practicality to encourage young students and the public to engage in wood furniture design and production The goal is to create original works that have not been previously sold or awarded More information can be found on the official website To ensure fairness and international perspectives in the selection process the competition has invited Kasper Holst Pedersen CEO and chief craftsman of the Danish furniture brand PP Møbler specializing in industrial design at Iwate University in Japan The competition aims to connect Taiwan's wood furniture design creativity with global trends and discover emerging talent in the field aims to attract both domestic and foreign wood art and design creativity through the competition leveraging Daxi's century-long history of wood art industry and excellent furniture making craftsmanship The competition's goal is to make Daxi a window to showcase Taiwan's wood furniture craftsmanship and design strength to the world shaping the brand image of "Furniture City." It also aims to provide a platform for domestic and foreign wood furniture creation and technical exchange offering various activities for people to experience and learn about wood art and promoting the consumption of wood life aesthetics The Daxi Wood Furniture Competition is accepting entries until May 31, 2023. Students and social creators from any country can participate in the two-stage competition by submitting registration forms and design drawings or photos of their works. Finalists will receive a subsidy of US$330 (NT$10,000) to make their works. Visit https://dfcd.tycg.gov.tw/ for more information This competition was submitted by an ArchDaily user. If you'd like to submit a competition, call for submissions or other architectural 'opportunity' please use our "Submit a Competition" form By 2018-05-09T06:00:00+01:00 Site powered by Webvision Cloud Book your cosmetic procedure consultation today. FIND A DOCTOR Treatment Trends a neurotoxin researcher and board-certified dermatologist in Beverly Hills In the pipeline though are a handful of truly distinct botulinum toxins aiming to break new ground “Several of the toxins that are currently in the trial phase or awaiting FDA approval are quite different in onset of action and longevity of effect,” adds Dr As these beautifying proteins evolve, so too do the ways doctors harness them. “At their inception, we used neuromodulators to soften signs of aging, to help our patients look younger,” explains Dr. Mitalee Christman But there’s since been a “vibe shift,” she says: “My patients tell me they want to feel refreshed They want their appearance to match their joy for life We’re moving away from paralyzing all motion to a softer look using different concentrations of neuromodulator top dermatologists weigh in on the injectable wrinkle relaxers of the future We’ve reported several times now on Daxi (daxibotulinumtoxinA for injection) the longer-lasting neuromodulator from Revance Supercharged with a performance-enhancing peptide Daxi has been shown to outlast all currently approved toxins smoothing glabellar frown lines for six months or more (versus the standard three to four months).  Depending on when it comes to market (the hope is later this year) Daxi could potentially be the first vegan neuromodulator “It’s a pure protein,” says Dr meaning it’s formulated without human serum albumin (a blood-derived stabilizer) and is free of accessory proteins.  “It is a beast of a toxin—I have never seen [another neuromodulator] get a 55-year-old, etched-in glabellar line table-flat,” adds Dr. Kavita Mariwalla a board-certified dermatologist in West Islip who served as an investigator in the trial Mariwalla believes it will be especially ideal for select patients including men with significant “muscle bulk”; people with creases that are very set in even at rest; and anyone “who just doesn’t want to come in all the time.” Daxi’s duration should allow patients to better coordinate their injectable touch-ups “It’s incredibly annoying when your filler is still in place but your frown line starts to reappear so quickly,” says Dr noting that a longer-lasting neuromodulator will be a “nice option for out-of-town patients who travel to see me for injections.” a board-certified dermatologist in Coral Gables who recently presented on forthcoming neuromodulators at the American Academy of Dermatology (AAD) meeting.  When injected immediately after skin cancer removal and repair it may help improve scarring by immobilizing treatment areas the toxin acts as a muscle relaxant in early recovery “The [toxin’s] fast onset may benefit patients who desire a rapid treatment for facial [wrinkles] before unexpected social or professional events,” the JDD authors write They expect the drug will also appeal to folks who are new to neuromodulators and want to trial the effects for weeks rather than committing for months By subscribing, you accept our Privacy Policy and Terms of Service and agree to receive marketing emails All four of the neuromodulators currently used in the U.S are freeze-dried and packaged as powders that require reconstitution “we may see two liquid toxins get FDA approval later this year.”  Relabotulinum toxin, or “QM toxin,” from Galderma (maker of Dysport and Restylane) is a type A toxin like all the versions currently on the market While the company and its investigators can’t divulge many details Kaufman insists that “the toxin is different—a different strain and different manufacturing—and it will have unique characteristics from our current toxins.”  Shamban adds that the liquid neuromodulator from Galderma is “highly purified,” with a clean profile similar to Daxi’s no accessory proteins.” (According to Galderma the product is “created using an animal-origin-free process.”) Dr Shamban also describes the drug as “very potent,” explaining that its integrity is maintained because it never goes through any sort of dehydration process It’s chemically similar to Xeomin but in liquid form Premixed toxins that come ready for injection will be more convenient for injectors—but what’s in it for patients Shamban: No mixing means “there’s no variability in effect.” With powdered versions injectors “may add different volumes [of saline] to reconstitute them which could affect their efficacy.” Because when dilution strategies vary some shots are bound to be stronger than others Letibotulinum toxin A, from the pharmaceutical company Croma-Pharma, recently wrapped phase III trials assessing the drug’s safety and efficacy for treating frown lines. It’s already available in 28 countries and is the leading toxin in South Korea But the tools don’t create the art—the best paintings are defined by the artist not the medium.” Finding an experienced injector whose aesthetic aligns with your own will help ensure you get the best result from whatever neurotoxin you choose to use—now and in the future More like this: This page requires JavaScript to function correctly please enable JavaScript in your browser settings first 5265TAIPEI (Taiwan News) — Last year the popular Daxi-Daxi Folk Festival (大溪大禧) canceled in-person celebrations in favor of an online event but it’s back Saturday (July 2) bigger than ever Daxi-Daxi is a pre-festival for Lord Guan’s birthday which falls on July 22 this year (the 24th day of the 6th month on the lunar calendar) The theme of the festival is “righteousness” and the special guest at the festival will be the Hsinchu City God and his generals Daxi-Daxi started in 2018 as an event that blends pop culture and tradition to breathe new life into the time-honored celebrations for Lord Guan Daxi-Daxi aims to encourage young people to participate and learn about traditional customs This year Daxi-Daxi collaborated with Lotus Wang (王彩樺) to create a new song for the festival called “紅紅OnOn.” The accompanying dance takes its inspiration from the traditional dance steps of Lord Guan’s generals According to the schedule on the Daxi-Daxi website this Saturday (July 2) visitors can expect a god parade and opportunities to learn about the history of Daxi from storytellers when the traditional celebrations carried out by Daxi Puji temple begin 8 Taiwan taboos to heed on Mid-Autumn Festival Taiwan art history gets NT$1.4 billion funding boost Defense ministry describes Taiwan's coming National Military Museum Taiwan's Amis Indigenous group honor Cepo' Incident heroes Maroon 5 announces Valentine’s Day concert in Kaohsiung Taiwan musical 'Take Out the Trash' offers refunds after detention of guest star Ko Wen-je Andover News Andover Fire Rescue extinguished a fire Sunday at the location of a restaurant that closed after a fire last fall Video from Sunday’s fire shows firefighters working to put out hot spots in Daxi, one of the three restaurants owned by Andolinis Restaurant Group that were closed after a fire on the block in October which caused an estimated $1 million in damage Firefighters in Andover are still actively putting out hotspots after a fire erupted at a restaurant called “Daxi” on Essex street. #Boston25 pic.twitter.com/sdjQWcRkAr Andover News asked Andolinis Restaurant Group for comment. A notice on the company’s Website saying the restaurants were temporarily closed has not been updated since October North Andover and Wilmington provided backup coverage as Andover fire responded to the two-alarm fire at 19 Essex Street Andover News has asked Andover Fire Rescue for more details and will update this story when we hear back from them We don’t spam! Read our privacy policy for more info Learn more about Andover News and what we're trying to do: Read our Mission Statement and Policies Copyright © 2025 Andover News Services Inc.All rights reserved Subscribe now to keep reading and get access to the full archive Face & Neck According to a report published by the American Society of Plastic Surgeons there were more than 7.4 million botulinum toxin type A injections and 2.6 million soft-tissue filler injections performed in 2018—and those numbers are only expected to have risen since Not only does the demand for injectables continue to grow but the expansion of new formulas is evolving too From toxins that last impressively long to fillers made for sensitive skin these next few years are expected to be exciting for cutting-edge noninvasives. We spoke to the experts about what makes these products different from the others and why we should be excited about them.  “DAXI has a proprietary peptide [that] differs from our currently available botulinum type A toxins.” Bonti is the new toxin being developed by Allergan. “This product should have an extremely quick onset of action [within 24 hours] but have a short effect, lasting two to four weeks” says Dr. Joshua Zeichner a board-certified dermatologist in New York City “It will be a great option for first-timers wanting to try out a treatment and can also help people who need a last-minute touch-up before a big event.” Related: Injectable Bruises? Been There. Here’s How to Handle Them Without Hiding Out. Juvéderm Volite is not a dermal filler but rather an injectable treatment intended to improve skin quality for up to nine months Volite contains skin-conditioning hyaluronic acid (HA) gel to help reduce the appearance of fine lines while also helping the overall tone and texture of the skin itself The main goal for this treatment is to help make the face look more hydrated rather than diminish the appearance of wrinkles or add volume to the face Not only is Volite used to hydrate the skin thanks to HA’s high water-binding capacity but it also helps increase overall elasticity too Word from Allergan is that we’ll have to wait until 2021 for this product to hit the U.S Juvéderm Volux is another hyaluronic acid (HA)-based dermal filler designed to replace lost facial volume Volux is denser than many fillers on the market—it’s made to mimic bone—and creates a more lifted look Because the consistency of the product is so dense it’s often used in the jawline and chin area to sculpt the area.Volux isn’t available in the U.S most likely won’t be available until 2021.  ProfHilo is a hyaluronic acid (HA) treatment that helps with skin laxity and it’s  free of 1,4-butanediol diglycidyl ether (BDDE) that links the HA chains to prevent them from being broken down by the body ProfHilo is unique because it’s able to remain stable and effective without BDDE And while BDDE is safe in small doses in dermal filler the fact that ProfHilo is BDDE-free really appeals to those consumers who are cautious of having synthetic chemicals used in their dermal fillers It also hydrates and can improve elasticity in the skin The injectable is currently available only in Europe and isn’t expected to launch in the United States until next year.  which gives the filler better flexibility in the skin to allow for natural movement and contains lidocaine to mitigate discomfort during the injection The cross-linking of the hyaluronic acid gel in Kysse has also been specifically developed to minimize swelling while producing results for up to a year the other lip filler in the Galderma family gives a plumper pout for up to six months) Kysse was shown to give long-lasting results for up to 48 weeks,” says Dr If you have sensitive lips or want a more subtle outcome than you may be seeing from other fillers you’ll want to keep an eye out for when Kysse becomes available in your doctor’s office later this year Related: 8 Dermatologists Say These Are Must-Dos Before Any Injectables Appointment the only fillers indicated for dynamic wrinkles and folds in the spring of 2020 and became available in provider offices in the fall The line of hyaluronic acid dermal fillers are designed to treat wrinkles such as the perioral (around the mouth) or periorbital (around the eyes) while also rehydrating the skin and improving skin quality “There are several products approved for use in different parts of the face such as the smile lines on the lips,” says Dr “The products use a specialized cross-linking technology designed to give longer-lasting results and to maintain its shape even in areas of high movement of the face.” What sets this technology apart involves three things: a long-chain HA that has high molecular weight and viscoelasticity; a gentler process to preserve more HA long chains; and the ability to support natural movement within the skin More like this: