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Kounis syndrome is a hypersensitivity reaction that induces acute coronary artery events
nevertheless its pediatric occurrence remains rare and often underdiagnosed
This report describes a fatal case of Kounis syndrome triggered by ceftriaxone-lidocaine administration in a child
in the context of sepsis and multiple organ dysfunction syndrome
A 4-year girl with a history of cyclic vomiting syndrome
was admitted to the ICU with severe lethargy and pallor 30 min after the second intramuscular injection of ceftriaxone
Her laboratories were pertinent for a metabolic acidosis
elevated cardiac markers (troponin I and cardiac-type creatine phosphokinase)
the patient’s condition continued to deteriorated
which lead to multiple organ dysfunction and eventual death
This case highlights the need for heightened clinical awareness of Kounis syndrome in pediatric settings
especially in patients with underlying infections
This case underscores the fatal potential of undiagnosed Kounis syndrome in the pediatric population and highlights the urgent need for enhanced vigilance and multidisciplinary preparedness
we present a fatal case of Kounis syndrome in a child with sepsis
A 4-year-old girl was urgently admitted to the ICU of the Regional Children’s Clinical Hospital at 240 a.m
which developed 30 min after the second intramuscular injection of ceftriaxone with lidocaine
Her parents denied any medical history of respiratory or other infections within 3 weeks before her admission
The illness developed acutely and was characterized by fever
Due to the patient developing these acute symptoms
her parents were referred to the primary health care unit for treatment of a likely bacterial infection
Considering the severity of the patient’s condition and the absence of bacteriological test results and antibiotic susceptibility data
ceftriaxone was empirically chosen as a broad-spectrum antibiotic for management of her likely bacterial infection
The parents denied a history of any significant medical conditions except for cyclic vomiting syndrome
which occurred several times over the past year
Her family history was pertinent only for type 2 diabetes mellitus
The parents denied any known allergies and she was up to date on routine vaccinations for her age
Initial hospital admission with suspected infection intestinal disease; starting management with ceftriaxone
Development of allergic reaction (30 min after the second dose of ceftriaxone)
Transferred to Regional Children’s Hospital ICU
Progressive decline in ejection fraction to 15%
Progressive deteriorating coagulation parameters
The patient was a well-nourished girl with a body weight of 20 kg (+ 1σ)
Vital signs included a body temperature of 36.5 °C and saturation (SpO₂) between 96% and 88%
The skin was markedly pale and dry and exhibited reduced turgor with perioral cyanosis
The child was stuporous (Glasgow Coma Scale score of 12 and a white spot test > 5 s)
tachypnenic with a respiratory rate of 24 breaths per minute
dullness in the lower lung fields bilaterally
She was tachycardic with a heart rate of 138 bpm
and on cardiac auscultation she had weak heart sounds
Her blood pressure on admission was 140/100 mmHg
There was no organomegaly on abdominal exam with the liver palpable 1.5 cm below the costal margin
the spleen was not palpable during the physical exam
The patient had been anuric for the past 24 h
The diarrhea (7–8 times daily) over the last 48 h
which coincided with the onset of fever and vomiting
Upon admission to the ICU of the Regional Children’s Clinical Hospital
and blood samples were collected for microbiological testing
these were non-revealing as the results were negative
Electrocardiography (ECG) revealed sinus tachycardia with clinically significant ST-segment depression (Fig. 1).
The ECG findings with signs of subendocardial myocardial ischemia
Echocardiography revealed significant cardiac impairment (Table 3)
Moderate mitral and tricuspid valve insufficiency were present
but myocardial wall thickness remained normal
No coronary artery abnormalities were observed
Chest X-ray: bilateral bronchopneumonia and multifocal pneumonia in the right lower lobe
Ultrasonography revealed renal parenchyma with markedly increased echogenicity and reduced systolic flow
the patient’s condition worsened due to multiple organ dysfunction syndrome
the child was placed on mechanical ventilation and induced into a pharmacologic coma (dobutamine 5–20 µg/kg/min
A – Fragment of jejunum with edematous mucosa and neutrophilic inflammatory infiltrates
Desquamation of the epithelium with a tendency toward erosive changes
signs of active crypt epithelial regeneration
and occasional crypt abscesses are observed (acute bacterial enteritis)
B – Lung tissue with thickened interalveolar septa and mononuclear inflammatory infiltrates with admixture of neutrophils
The alveolar epithelium is flattened and damaged; numerous hyaline membranes are observed
Occasional alveolar spaces contain exudate
Vascular congestion and microthrombosis (pneumonia-associated diffuse alveolar damage)
C – Adrenal gland with massive extravasation of erythrocytes (hemorrhage) into the cortical and medullary regions
causing disruption of the gland’s histoarchitecture
Microloci of coagulative necrosis with loss of cellular borders and karyolysis
Microloci of inflammatory reaction zones (Waterhouse-Friderichsen syndrome)
D – Renal medulla with mostly preserved histoarchitecture
Foci of tubules show necrotic and apoptotic epithelial changes
Numerous vessels exhibit signs of stasis and thrombosis
with single perivascular inflammatory cells present (focal acute tubular necrosis of renal tubular epithelium
The final clinical diagnosis: Bilateral focal necrotizing pneumonia with abscess formation
complicated by toxic syndrome and grade III respiratory failure; infectious-toxic shock; sepsis with multiple organ dysfunction syndrome; anaphylactic shock; and Kounis syndrome
concurrently a hypersensitivity reaction culminated in acute coronary syndrome
resulting in a fatal outcome within less than a day
This case highlights the diagnostic challenges of Kounis syndrome in pediatric patients
particularly along with severe infectious complications
The fatal outcome underscores the importance of considering allergic myocardial involvement in critically ill children with signs of cardiac ischemia following drug administration
Increased awareness and early recognition of Kounis syndrome could improve outcomes through timely intervention and tailored therapeutic strategies
No datasets were generated or analysed during the current study
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Department of Children’s Diseases of Postgraduate Education
Ivano-Frankivsk National Medical University
VB - acquisition and data analysis; TK - data interpretation
All the authors have read and approved the final version of the manuscript
This case report was conducted in accordance with the principles outlined in the Declaration of Helsinki and adhered to ethical guidelines
Informed consent was obtained from the parents of the patient
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DOI: https://doi.org/10.1186/s12245-025-00886-4
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