Home > News By Simon Hacker | 3rd September 2024 A "dream" livery operation with a dressage arena which was built without planning permission may have to saddle up if planners don't agree to a retrospective request for the work has been told by Forest of Dean District Council that a change of use of land to equestrian the construction of a dressage arena and various extensions who built the facilities with her husband on her father's 40-acre farm at a cost of more than £50,000 told Punchline-Gloucester.com that while setting up the equestrian business had been her dream she had already changed direction – and now hopes to be able to keep the development solely for personal use and when I stepped in I took on sheep farming which I was so bad at that everyone was shouting at me which was when I realised I could pursue my dream of a livery business." She said that a well-recognised local shortfall in livery, as recently reported in Punchline suggested the idea had realistic prospects for success as a diversification move But she added that with six horses now being owned by her family the investment would be exclusively for personal use grazing has now been taken up on land eslewhere by about 30 horses but that is on a clear basis of being separate to this Documents submitted to planners indicate that the work which was recently begun was virtually completed in anticipation of being able to start the operation in October last year when Ms Ispas listed Boseley Stables as a new opportunity for riders In a social media post she stated: "I have just opened a new livery yard in Westbury-on-Severn brilliant facilities with amazing riding including woodlands of Worcester-based Addison Rees Planning Consultancy Ltd told planners the proposed development is "not for commercial use" Mr Rees said the site sits on a parcel of land measuring 0.35ha and adjacent to the applicant's home adding: "The scheme also includes a new dressage arena to the north of the stables This area would have a 1.2m timber post fence with an equine recycled rubber flooring." An extension to the existing stables building was also requested: "This will provide four further stables The materials are to match the existing building." a new menage arena was proposed on the southern boundary which would span 33m by 23m and have the same fencing as flooring spec as the dressage arena Opinion marks early verdict on Labour amid Shire Hall shakeup The project has been more than a decade in the making and could see 620 acres of greenbelt transformed into a new town It has revealed plans to open a branch in town as part of a rapid expansion Forest of Dean venture shares its fears amid new burden Reproduction of any content is strictly forbidden without prior permission We use cookies to help make our website better. For more information on cookies and how to block them, visit https://ico.org.uk/for-the-public/online/cookies/ Volume 3 - 2022 | https://doi.org/10.3389/falgy.2022.1009437 This article is part of the Research TopicIn Vitro Diagnosis of Allergic and Mast Cell-Related DisordersView all 10 articles Food allergy is a global health problem affecting up to 10% of the world population is still a major challenge in medical offices and for patients seeking alternative avenues of diagnosis A flawless test to confirm or rule out a food allergy does not exist The lack of optimum testing methods to establish precise clinical correlations remains a major obstacle to effective treatment but they have been used primarily as an analytical tool and not to establish clinical correlations Most allergy tests are still carried out within the laboratory and skin tests outside a laboratory setting that are used for food allergy diagnosis rely on non-standardized allergens Epitope mapping and basophil activation test (BAT) have recently been proposed as a means of establishing better clinical correlations Yet neither have received FDA clearance for widespread distribution the BAT has the advantage of being a functional assay several large private practice groups in the United States have developed BAT as a clinical assay and have started using it in patient care the vast number of papers published on BAT (more than 1,400 as of 2022) and the trend toward increasing FDA regulation it is essential to understand the roadmap for regulatory clearance of this assay physicians treating food allergies often base their decisions on personal experience Basophil activation test is a good measure to assess clinical reactivity to prevent unnecessary food challenges Determine basophil activation by flow cytometry The initial gating aims at isolating singlets and removing eosinophiles neutrophils and to some extent monocytes and DC's The subsequent basophil identification where basophils are identified based on their surface markers Lastly the activation determined by CD63 and CD203c are shown for the two negative controls (PBS and KLH) the two positive controls (Anti-IgE and fMLP) and the peanut allergen Each clinical laboratory establishes optimal allergen-specific cutoff limits for the specific question the test is being used in the clinic Clinical relevance of different types of dose-response curves (i.e. bimodal and plateau) still need further investigation Sample sources and laboratory location for BAT in the United States Dark circles represent sources for the blood samples Size of each circle represent sample size from each location Total samples are over 1,000 between year 2018 and 2021 The yellow symbols represent CLIA/CAP accredited laboratory locations capable of performing BAT as an LDT BAT has the potential to be a more effective diagnostic tool in the U.S. if a consistent nationwide standard under the FDA could be established. To develop such a standard, it is important to determine at which point of the diagnostic process this test should be performed. The most practical utility of BAT is to guide a food challenge decision (20) BAT can also help determine appropriate candidates for oral food immunotherapy natural resolution of food allergy and monitoring response to immunotherapy Since BAT is a functional assay and uses multiple allergen concentrations to obtain dose response curves the information obtained from this test allows for a much more detailed picture of the response to the food allergen Such studies will most likely require several hundred subjects to obtain robust sensitivity and specificity data In certain cases, BAT can predict the severity of clinical reactions as well as the prognosis of the patient's food allergy (36) BAT can predict thresholds of reactivity to help determine dosing of the patients as well as degrees of tolerance will require controlled clinical trials and the establishment of a federal standard that is country wide For egg allergy, BAT has a sensitivity of 63% and a specificity of 96% for CD203c expression and a sensitivity of 77% and a specificity of 100% for CD63 expression. These numbers are much better compared to performance of skin testing or sIgE for egg (38) Although these studies show that BAT has potential clinical utility not all used OFC as the comparator and results are very variable due to variations used in allergen preparations The use of allergen components may lead to better performance of BAT for these allergens and their clinical correlation In tests where basophils do not respond to anti-IgE stimulation, negative results to allergens should generally be considered un-interpretable (39). If basophils are not reactive to the anti-IgE control but show response to the allergen, BAT can be considered positive as long as there is no non-specific activation in the KLH control or other non-allergic control individuals (40) Differences between Laboratory Developed Tests and FDA-Cleared Tests The FDA in principle has the authority to intervene in cases in which patient safety is jeopardized. The FDA in most cases has not enforced its authority (enforcement discretion) on LDTs because LDTs have generally been simple laboratory assays or have been used in a very controlled fashion. Laboratory testing personnel and clinicians have also often operated within the same institution or clinical practice (43) This had provided a safety net in clinical utility and potential adverse events related to the testing outcomes advances in technology and new business models has resulted in more complicated LDTs that present greater risks and which are more similar to other FDA approved tests that have undergone premarket review the FDA announced its intention to reconsider its enforcement discretion for LDTs a bill called the VALID Act has been proposed to increase FDA oversight on LDTs FDA approved tests can be distributed widely and sold across state lines and for this purpose need very strictly defined clinical indication and reporting—two important points that will need to be clearly defined for BAT in the process of FDA clearance of an LDT Innovations in diagnostics have helped advance many therapies BAT is a flow cytometry-based diagnostic test Its record of reviewing such tests offers lessons for what is needed for BAT approval After the publication of the ASR rule in 1997 some manufacturers started bundling individual ASRs together to form reagent cocktails This conflicted with the definition of the single reagent ASRs rule that the FDA had defined the FDA clarified the intentions of the ASR rule in the Guidance for Industry and FDA Staff on Commercially Distributed Analyte Specific Reagents (ASRs) the FDA states that “bundling of ASRs into a panel of multi-analytes is inconsistent with the definition of an ASR” most multi-analyte reagents/cocktails were withdrawn from the market to comply with this new ASR ruling.2 The next events in the regulation of clinical flow cytometry were three CDER FDA sponsored public workshops in 2013, on minimal residual disease (MRD) in leukemias and Clinical Flow Cytometry and Hematologic Malignancy. Ultimately, this same approach was applied to the standardization of MRD in plasma cell neoplasms (MM) and resulted in a Special Issue of Clinical Cytometry (46) A Flow Cytometric Devices Guidance Document was released via the Federal Register on October 14 After several unfavorable comments to the docket The major criticism was that it did not address the issues of hematologic malignancies and that it was outdated Prior to the publication and withdrawal of this second FDA flow cytometry guidance document there was a consensus document prepared and published by two professional organizations: the International Council for Standardization in Hematology (ICSH) and the International Clinical Cytometry Society (ICCS) These Practice Guidelines (2013) consisted of the following: preanalytical issues; analytical issues; post analytic considerations and assay performance criteria These Practice Guidelines were submitted to the FDA for review as a recognized standard The decision was out on hold due to an announcement that Congress was going to pass the Valid Act A decision concerning these guidelines is still pending FDA evaluated the ClearLLab Reagents through their de novo premarket pathway and cleared the test and the reagents based on the tests performance in a clinical trial The clinical study was performed on 279 patient samples using other detection methods of malignancy as a comparison The results of this study showed that the assay correctly identified a cancer presence 84.2% of the time which agreed with the clinical trial site's diagnosis in over ninety percent of the cases Finally, a proposed down classification for clinical flow cytometers was posted in the Federal Register on March 6, 2019. However, it was put on hold with the onset of the COVID-19 pandemic.4 A new Clinical and Laboratory Standards Institute (CLSI) document entitled H62 Validation of Assays Performed by Flow Cytometry was released on October 27, 2021 (47) This document has been submitted to the FDA for consideration as a recognized standard in clinical flow cytometry Taking the BAT test through the FDA pathway will ensure reproducibility across laboratories by standardizing the test reagents (antibodies The FDA approval process will ensure standardization of basophil identification in peripheral blood samples and a specific indication for the use of BAT The validation will happen through a multicenter clinical trial Since the approval of FDA's Medical Device Amendments in 1976 the agency has tightened its stance on enforcing LDTs starting to target how certain laboratory tests are used and marketed The FDA has used its discretion in certain scenarios where it felt the safety and the accuracy of the tests were impacted but not take broad steps to regulate LDTs in general as of now There was a significant change in FDA's perspective in 2014 when a draft guidance was published that described the plan to phase out FDA enforcement discretion and to fully regulate LDTs This guidance led to debate raising concerns about the FDA regulating LDTs as that is currently performed at the state level There was also concern that changing a longstanding regulatory policy might result in decrease in innovation and patient care some have questioned whether FDA has the necessary infrastructure to regulate the complex LDT market deliberations in both the Senate and the House resulted in a decision to delay the authorization of the law to a later date Even though the VALID act may not pass during the current United States administration it is clear that the discussion will continue Engaging with the FDA to approve tests such as BAT will allow for a better understanding of the process of the clearance of the use of flow cytometry for different indications as the regulatory landscape for laboratory testing goes through changes in the United States The best guidance that is currently available for developing FDA cleared flow cytometry based testing comes from the September ICCS 2020 virtual meeting which addressed minimal residual disease (MRD) detection titled “Flow cytometry-based minimal residual disease analysis assays submitted for FDA Clearance: Regulatory Perspective” The presentation outlined three regulatory pathways for clinical flow cytometry assays: (1) LDTs (2) Investigational Device [Exemption (IDE)] and (3) the IVD 510(k)/de novo LDTs were and remain under enforcement discretion the IVD pathway is more demanding in that it must be determined to be substantially equivalent to a predicate device Regulatory clearance pathway for a BAT kit For a CLIA or CAP certified laboratory currently performing BAT as an LDT including a summary of the results of the LDTs for potential FDA review will be critical The data includes basophil identification (manuscript in preparation) as well as the performance of the testing with clinical correlation Such a summary along with an SOP should already be in place for both CLIA and or CAP inspection of the LDTs This will provide the FDA information on the performance of the test and help in the design of the study for FDA clearance Any FDA clearance path will also require a clinical trial to support the indication for the test Such a trial should be designed only after discussions with the FDA on the technical aspects indication for the use of the test as well as patient size of the clinical study Good Manufacturing Practice (GMP) to standardize allergens for use in diagnosis and treatment is a critical regulatory requirement by the FDA Allergens are derived from natural sources and sterilization that results in allergen heterogeneity A consistency within the manufacturing process will improve the efficacy and the safety of the BAT Sourcing of peanut flour for BAT from a food-grade peanut manufacturer will be the starting point for test substance manufacturing The clinical correlation of recombinant molecules (i.e. etc.) versus native peanut allergen has not been studied as extensively but may provide added value in clinical correlations ASRs are raw materials and components that are used to develop a laboratory assay the key characteristic of each component of an ASR is its ability to attach to or react with a substance whose detection is clinically meaningful ASR rule requires that manufacturers list proprietary name and quantity or concentration of the reagent; the source and a measure of its activity; and the name and place of business of the manufacturer There also needs to be an establishment of registration and compliance with FDA's quality system regulation and ASR labeling and distribution requirements peanut and control allergen) as well as reagents that stimulate basophils (e.g. This can be a potential hurdle for clinical BAT. Temperature control boxes, choice of anticoagulant (heparin is the preferred option), time frame before the test would become invalid will need to be part of the clinical trial readout. In a recent paper, we demonstrated very minimal impact of transport on blood samples (33) For patents related to diagnostic subject matter case law stipulates there are several types of claims to try to meet eligibility These include (a) method of preparing samples for analysis (b) method of diagnosing + treating (d) a kit and (e) a method of diagnosing for ex-US filings are important to consider Recent developments in fundraising options (e.g. crowdfunding) allowing the greater allergy and patient community to invest will facilitate such a testing process to go through the clinical trials and regulatory process With the Jumpstart Our Business Startups (JOBS) Act of 2012 signed into law by President Barack Obama on April 5 of that year equity crowdfunding has emerged as a viable source for early-stage seed capital early stage ventures could raise a maximum of $1.07 million in a 12-month period from both accredited and non-accredited investors so long as the funding round in question is hosted on a Financial Industry Regulatory Authority (FINRA)-approved crowdfunding portal this maximum was increased to $5 million per 12 month period A total of $486.8 million was raised in 2021through 1,448 individual regulation crowdfunding (also referred to as RegCF) rounds The crowdfunding investment market has held firm despite recent economic weakness with $235.1 million investing via regulation crowdfunding (RegCF) in the first half of 2022 compared with $219.4 million in the same period in 2021 BAT has been used as a research test now for over 30 years this test has been validated for use in diagnosing and monitoring food allergies as a laboratory developed test in the United States Given the increase in demand for BAT from clinics treating patients with food allergies as well as many centers looking to develop their own LDTs for this test it is time for its standardization and FDA clearance FDA acceptance of the first peanut OIT in 2017 and increasing use of BAT in clinical trials of emerging food allergy therapeutics are additional reasons for pursuing agency approval for this test Establishing BAT as a platform to test many food allergens and the standardization of the reagents and food antigens used in this assay will improve patient care as well as research in food allergies The raw data supporting the conclusions of this article will be made available by the authors GM contributed to conception and design of the study OA and GM wrote the first draft of the manuscript All authors contributed to manuscript revision Authors thank Michael R Gordon for his critical review Lydimarie Aponte for graphical illustrations Ivan Santos for masterfully managing and coordinating of the BAT testing throughout the USA SO’R was employed by New Columbia Capital The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 1https://www.fda.gov/medical-devices/in-vitro-diagnostics/laboratory-developed-tests 2https://www.fda.gov/regulatory-information/search-fda-guidance-documents/commercially-distributed-analyte-specific-reagents-asrs-frequently-asked-questions 3https://www.fda.gov/news-events/press-announcements/fda-allows-marketing-test-aid-detection-certain-leukemias-and-lymphomas 4https://www.federalregister.gov/documents/2019/03/06/2019-03967/medical-devices-exemption-from-premarket-notification-class-ii-devices-flow-cytometer-instruments 5https://www.cap.org/advocacy/latest-news-and-practice-data/june-15-2022 6https://www.help.senate.gov/hearings/s-4348-s-958-s-4353-hr-1193-and-s-4053 The epidemiology of food allergy in the global context PubMed Abstract | CrossRef Full Text | Google Scholar Prevalence of common food allergies in Europe: a systematic review and meta-analysis PubMed Abstract | CrossRef Full Text | Google Scholar and limitations of ex vivo basophil activation by flow cytometry in allergology: a narrative review PubMed Abstract | CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar Immunocap isac in food allergy diagnosis: a systematic review of diagnostic test accuracy PubMed Abstract | CrossRef Full Text | Google Scholar An approach to the office-based practice of food oral immunotherapy Office-based oral immunotherapy for food allergy is safe and effective (2011) 127(1):290–1; 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Accepted: 30 November 2022;Published: 9 January 2023 © 2023 Alpan, Wasserman, Kim, Darter, Shah, Jones, McNeil, Li, Ispas, Rathkoph, Perez, Siri, O'Connor, Plassmeyer, Romito, Pettibone, O'Reilly, Sønder and Marti. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Oral Alpan b2FscGFuQGFtZXJpbW11bmUuY29t Specialty Section: This article was submitted to Therapies a section of the journal Frontiers in Allergy Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish NEW COMMIT: Distance ace Alex Ispas of Coto de Caza has announced his verbal commitment to Northwestern University as a member of the Wildcats’ class of 2025 He will arrive in Evanston, Ill. at the start of the 2021-22 season along with Tyler Lu and Daniel Matheson “I am proud to announce my verbal commitment to swim and study at Northwestern University I would like to thank everyone that has supported me through this process who does his club swimming with Mission Viejo Nadadores Open in December and most recently posted a pair of top-20 finishes at College Station Sectionals in March he raced to 18th place in the mile at Juniors West While representing the Austrian Swimming Federation internationally Ispas competed in three events at the 7th FINA World Junior Championships in Budapest He also placed 13th in the 1500m free and 15th in the 800m free at the LEN European Junior Championships last summer Also competing for Santa Margarita Catholic High School Ispas finished 12th in the 500 free at the CIF State Championships during his sophomore season at the CIF Southern DI Section Championships the week prior as well Ispas would’ve finished 23rd in the mile at the 2020 Big Ten Championships. Northwestern finished fifth overall in the team standings at last seasons’s conference meet, and Katie Robinson has recently been tabbed the Wildcats’ new head coach please send a photo and quote via email to hs@swimmingworld.com Welcome to our community. We invite you to join our discussion. Our community guidelines are simple: be respectful and constructive, keep on topic, and support your fellow commenters. Commenting signifies that you agree to our Terms of Use ' + scriptOptions._localizedStrings.webview_notification_text + ' " + scriptOptions._localizedStrings.redirect_overlay_title + " " + scriptOptions._localizedStrings.redirect_overlay_text + " CA — We all know student athletes who also bring their A-game to other parts of their lives we've launched an initiative to help recognize these heroes making a difference in their communities We’re working to let all your neighbors know the individual stories behind the leaderboard This submission comes from Mihai Dan Ispas who nominated his son What sport does the star student athlete play Why do you believe the star student athlete should be recognized participated to a lot of international competitions- EYOF What's one thing you want everyone to know about the star student athlete This content is brought to our community in partnership with T-Mobile Know an outstanding student athlete? Nominate them as a Patch Star Student Athlete. Get more local news delivered straight to your inbox. Sign up for free Patch newsletters and alerts. Kindness can transform someone's dark moment with a blaze of light who now has a new roof thanks to Korellis Roofing Ispas suffered a life-threatening gunshot wound during a duck hunt outing in Southern Indiana The Highland native recovered miraculously from his wounds but they would ultimately confine him to a wheelchair But the incident did not change his faith in man community members kindly helped him in various ways Roofers Local 26 of Merrillville were contacted to see if they could help Ispas with his leaking roof “We felt great about being able to help Tim,” said Joe Pozzi business representative and organizer of the Local 26 Ispas found he was in need of additional roofing assistance and a new generation of union roofers has answered the call training director and apprentice coordinator for Roofers Local 26 J.A.T.C. and his team stepped up by providing the knowledge and labor to remove and install an EPDM (rubber) fully-adhered tapered system roof design Roofers who volunteered their time for the job considered the project a rewarding experience “When I heard we roofed Tim’s house in 2004 and we were asked to do it again I was without a doubt thrilled to be a part of it and did not hesitate to lend a helping hand It makes me proud to give back and make a difference in someone’s life in the community,” said volunteer Austin Markle of Local 26 This volunteer project would not have been possible without the building materials and work donated by Korellis Roofing Inc alongside the hard-working individuals of Local 26 “What the union workers did helped us avoid costly repairs and uplifted my spirits For more information about Korellis Roofing Share Good News Contact Us Meet Our Team Version française  - Versión española the UNCTAD Debt Management and Financial Analysis System (DMFAS) Programme and ZHAW School of Management and Law started a collaboration aimed at ensuring compatibility of the upcoming DMFAS software (version 7) with International Public Sector Accounting Standards (IPSAS) standards.  The output of the collaboration will be the design of a new functionality in DMFAS 7 for the calculation of amortized cost as per IPSAS 41 (financial liabilities) This new feature will be part of a series of improvements in the DMFAS software including the expansion of debt data coverage new features for debt operations and transactions It is expected that DMFAS 7 will respond to the needs of an increasing number of DMFAS user countries adopting the IPSAS methodology to calculate debt positions based on accrual accounting (i.e. the calculation of amortized cost) in conformity with international standards This will also facilitate the integration of DMFAS with national integrated financial management information systems.  An initial workshop took place on 22 and 23 April in Geneva during which experts from DMFAS and ZHAW examined the needs for specific developments to make DMFAS 7 IPSAS 41 compatible The very fruitful discussions focused mainly on how generate calculations in DMFAS in line with IPSAS 41.  The next step will include a detailed needs assessment and a user requirement definition for the development of this functionality in DMFAS 7.  This workshop was made possible thanks to the support of the Swiss State Secretariat for Economic Affairs (SECO) which is facilitating collaboration between the DMFAS Programme and ZHAW School of Management and Law SECO has been a strong supporter of the DMFAS Programme for over 25 years The Project Support Partnership (PSP) between SECO and ZHAW School of Management and Law in the area of Public Financial Management began in 2008 and focusses on Public Sector Accounting and Auditing hated the endless hours that brought it closer.This is the day that Steven Arthur &#151; the man who shot Ispas damaging his spinal cord irreparably and leaving him a quadriplegic &#151; will walk out of prison a free man."He\'s being released and he\'ll be able to go on with his life," Ispas said "I\'m the one serving the life sentence."Eight years ago Ispas was a 24-year-old enrolled in classes at Purdue University-Calumet at Hammond He was working full-time for UPS and was planning to pop the question to his girlfriend in a few months.But that all changed on Oct on a lake in western Greene County.The two had been hunting for a few hours when they heard a shot that sounded like it came from a nearby road They saw a Ford Mustang pull up and two men get out.A few minutes later they heard a second shot that sounded even closer.Meier yelled in the direction where they\'d seen the two men and the two sped off in the car.About an hour and a half later the hunters were retrieving two ducks they\'d just shot when they saw the car again.Another shot rang out the .22 caliber bullet lodged in the back of Ispas\' neck between his fourth and fifth vertebrae paralyzing him instantly."My whole life changed in the pull of a trigger," Ispas said who arrested him and preliminarily charged him with attempted murder But Arthur maintained he was only trying to scare the hunters or sink their boat and didn\'t know he\'s shot anyone Investigators decided there wasn\'t enough evidence to prove he intentionally hit Ispas.Arthur was charged with criminal recklessness resulting in serious bodily injury a felony.Eight years and hundreds of cases later Greene County Prosecutor David Powell has no trouble recalling the details of the shooting case."It was horrible "It was one of those cases where you wish you could wave a magic wand and take away the injury."But he stands by his decision not to charge Arthur with attempted murder."On the other hand "No one was trying to do Arthur any favors here It\'s my obligation to be objective."Since both Arthur and his 15-year-old companion said Arthur wasn\'t trying to kill Ispas and didn\'t even realize he had shot him he said."I\'ve always said justice and fairness are not synonymous "It\'s just not the outcome everybody hoped for."Arthur was also charged with felony theft and misdemeanor cruelty to an animal The theft and cruelty to an animal charge related to an incident that happened later that day when Arthur and the juvenile were also accused of shooting a cow in a pasture near Carlisle cutting off its hindquarters with a knife and putting the meat into Arthur\'s 1983 Ford Mustang.Through a negotiated plea agreement Arthur plead guilty to the criminal recklessness and theft charges in return for the dismissal of the cruelty charge and a petition to revoke a suspended sentence in an unrelated case.He was sentenced to 11 years in prison and ordered to pay Ispas more than $100,000 in restitution an additional three-year sentence was tacked on from an unrelated drunken-driving case.Arthur is set to be released today which isn\'t an easy thing for Ispas to contemplate.Although he\'s since completed his schooling and now holds a master\'s degree he can\'t work a regular job &#151; in part because of his special needs but also because he would lose the disability and Medicaid benefits that cover his expensive round-the-clock care.But perhaps the worst for the formerly active young man who loved to hunt work and just hang out with friends is having to rely now on others to do everything for him."Tim is trapped in his body," his mother "Why should the person who caused this tragedy be able to get out of prison and go on living a normal life?"<em>Reporter Bethany Swaby can be reached at 331-4373 or by e-mail at bswaby@heraldt.com.</em> Philadelphia’s future workforce depends on collaboration and early outreach especially to better engage underrepresented communities.  “The more that we are doing to expose people to opportunities support them through the very real barriers of representation as well as [the] very real barriers of life,” said Nikki Pumphrey the Chamber’s vice president of talent and workforce in reference to barriers to entry for talent.  This work is coming at a critical moment.  Major employers are confronting significant hiring gaps and a mismatch between available roles and local skill sets but the city’s existing infrastructure offers plenty of room for cross-sector partnerships “We can make sure that the net that we’re building for our young people and our young adults is secure fewer people go through,” said Alina Ispas Montbriand senior director of project strategy and operations at Boomi.  Workforce development conversations have intensified as Philadelphia looks to remain competitive in a rapidly shifting economy.  Many local workers face barriers such as housing or food insecurity Yet momentum is building around new ways into the workforce like apprenticeships long-term mentorship and inclusive hiring processes The Chamber and partner organizations have been addressing these challenges for years but now they’re joined by a growing number of tech firms and nonprofits Each one is seeking to meet the city’s demand for skilled labor while advancing equity Pairing quantitative impact metrics with anecdotal employee experiences can make the case for new investments or expansions panelists warned of a healthcare workforce deficit that could worsen without a unified approach They emphasized that in the next five years nearly every job will require new skills.  Growing companies must incorporate diversity and inclusion from the start rather than retrofitting these goals later “It makes me so excited to hear when people are starting and growing businesses because you don’t have any of the infrastructure,” Pumphrey said You could bake in equity at the ground floor.”  Join 5,000 tech professionals and entrepreneurs in our community Slack today Your support powers our independent journalism we count on your personal and organizational contributions The dates displayed for an article provide information on when various publication milestones were reached at the journal that has published the article activities on preceding journals at which the article was previously under consideration are not shown (for instance submission Journal of Hazardous MaterialsCitation Excerpt :Meanwhile a complex structure of Cr(III) was formed through hydroxyl-carboxyl chelation facilitated by masking agents such as tartrate and citrate A molecular identification guided process using a suite of combined mass spectrometry (MS) methods has been proposed in recent studies including cation ion chromatography (CIC)-inductively coupled plasma (ICP)-MS size exclusion chromatography (SEC)-ICP-MS and electrospray ionization high-resolution mass spectrometry (ESI-HRMS) [155,156] for identification of nickel-bearing complexes The comparison of the results obtained from CIC-ICP-MS and AIC-ICP-MS provided the relative distribution of free Ni ions and charged complexed Ni at trace level Chemical Engineering JournalCitation Excerpt :Three-dimensional fluorescence spectra of samples were measured by fluorescent spectrometry (F-7000 and the fluorophores in spectra were divided into six regions [24] The ligand identification of Ni-complexes in the effluent was performed by high-performance liquid chromatography (HPLC Agilent) coupled with a quadrupole time-of-flight mass spectrometer (6546 Q-TOF MS Agilent) equipped with dual Agilent jet stream electrospray ionization source (AJS-ESI) [25] with small changes where the ratio of methanol was increased to obtain higher amount of detected complexes The mobile phase gradients are shown in Table S3 Science of the Total EnvironmentCitation Excerpt :Co(II) and Ni(II) cause serious symptoms and diseases such as nausea The effluent discharge concentration limits for Co(II) and Ni(II) in general areas in China are 1.0 and 0.5 mg/L (Wang et al. To reduce pollutant emissions of Co(II) and Ni(II) have been used to the remove Co(II) and Ni(II) from wastewater (Liu et al. Water ResearchCitation Excerpt :To meet the stringent discharge standard of Ni the overdosed Fe in the Fenton unit brought about large amount of sludge which considerably elevated the operating cost Due to the unsatisfactory efficiency of Ni removal by the current treatment process alternative advanced oxidation technologies to replace Fenton were in great demand (Wang et al. among which ozonation was considered a promising option ozonation may outperform Fenton in heavy metal decomplexation efficiency due to autocatalytic effect from the amine-N-bearing ligands (Huang et al. All content on this site: Copyright © 2025 Elsevier B.V. cognitive ability and personality data from two samples of Chinese and Romanian workers from the same company were collected and contrasted with performance data collected at two points in time Etic personality constructs in the area of conscientiousness have criterion validity for both the Chinese and the non-Chinese sample Emic personality dimensions don't have incremental validity over etic traits for the Chinese sample Potential predictive bias associated with measures of cognitive ability and personality on a sample including Romanian and Chinese working adults was also investigated.IntroductionDue to the rapid and continuing globalization of labor it is quite common for contemporary organizations to have a workforce consisting of both native and immigrant workers Do the well-established predictors of job performance such as general mental ability or conscientiousness predict job performance for both native and immigrant employees Do culture-specific psychological constructs play an important role in predicting work related outcomes?Extant research indicates that personality traits predict job performance across virtually all jobs and along the whole range of job complexities (Schmidt In addition to their direct relationship with job performance (Ones personality traits have incremental validity over cognitive ability (Schmidt & Hunter and can reduce adverse impact against protected groups (Hough Reviews published during the past decade acknowledge the fact that early debates regarding the role of personality assessment in I–O psychology have now been mostly resolved: an impressive amount of evidence indicates that personality traits are valid predictors of job performance (e.g one of the central controversies in personality research has to do with the relatively low personality validities in predicting organizationally relevant outcomes This issue has been tackled time and again via different approaches such as matching predictors to criteria or uncovering additional performance variance explained by traits lying beyond the FFM Potential personality related variance could be explained by culturally specific personality (emic) personality dimensions.The “emic” approach to personality focuses on formulating personality theories debating constructs and delineating measurements which refer to constructs which are specifically salient and meaningful for the indigenous culture (Church These dimensions typically lay beyond the FFM (e.g Some of the emic dimensions identified so far are Interpersonal Relatedness dimension covering harmony and reciprocity in relationship (China) becoming through others (South-Africa) (Valchev et al. 2011).The existence of these traits does not suffice to assume that the respective dimensions are performance relevant Culture shapes the patterns of social investment or of the investment and commitment to work and as a result both the roles and the behaviors associated with them vary between cultures to a greater or lesser extent (Lodi-Smith & Roberts This differential knowledge and cultural values are transferred from parents to offspring resulting in different values and behavioral patterns in adulthood (e.g Specific culturally moderated behavioral patterns can then in turn influence the way in which individuals seek interact with or respond to the different demands of the work environment we investigated the incremental validity of emic personality dimensions over etic personality dimensions in predicting job performance:H1 View more referencesCited by (8)An emic-etic approach to personality assessment in predicting social adaptation, risky social behaviors, status striving and social affirmation2018 Journal of Research in PersonalityCitation Excerpt :The findings mentioned above are partially congruent with those of Cheung et al (2008) showing that an emic-etic approach brought incremental validity in clinical settings specific to the Chinese context Also partially similar findings were obtained by Ion et al who showed an emic-etic approach to have incremental validity in predicting job performance in the case of Chinese workers Analysts expect the speech recognition market to reach close to €23 billion by 2026 growing 16.8% on average between 2021 and 2026 One of the drivers behind this growth is the increasing demand for biometrics in the banking financial services and insurance industry to help tackle fraudulent transactions increasingly adopted by consumers in the detriment of traditional search by adding the option to search for text within audio and video files content managers can better and faster understand It is this use case that propelled the Romanian startup Vatis Tech to launch an infrastructure solution in the speech recognition market: “We started with the idea to search in audio I listen to more podcasts and audio content and often I need to search inside their content but I don’t have the necessary tools,” Adrian Ispas tells The Recursive the company offers search and transcription infrastructure for audio and video content offering users a fast way to accurately identify terms in this type of content The tests performed so far indicated a 94% accuracy of transcription which is 10% higher than that of competitors Part of the reason is that the company’s speech recognition and machine learning algorithms are specialized for various industries and verticals Adrian Ispas further explains the company’s current business model: “We changed our initial plans of building a B2C platform for podcasters and general users because we quickly realized that the necessary technology to implement our vision doesn’t exist we’ve started to develop the technology we pivoted more to a B2B business and a provider of speech recognition infrastructure.” The model includes a subscription option for users with a smaller data volume The enterprise version offers dedicated support and infrastructure for corporate customers Developers can use the on-cloud and on-premise APIs to integrate Vatis technology into their products and services benefiting from dedicated support and taking advantage of advantageous prices Vatis Tech aims to have recognition algorithms for European languages such as French Recently, Vatis Tech raised €200K from Early Game Ventures, Sparking Capital as well as accelerate the development process “We already have a stable version for static transcription and a beta version for our real-time transcription API and on-premise version and we’re planning to release a stable version of it in the next few months we’re planning to develop new algorithms for transcription post-processing to improve the current accuracy and develop new verticals for Romanian language,” Adrian Ispas adds Investors are confident about the startup’s winning formula points out the solution’s relevance for business leaders who want to improve the customer experience or gain a competitive advantage through voice recognition integrations believes in the company’s opportunity to tap into a growing market that still has room for innovation Over 1 million people from all over the world have learned about the tech ecosystem in Central and Eastern Europe thanks to The Recursive In order to keep our content free for everyone If you believe what we do is important and have the means to do so support us in giving a voice to Central and Eastern Europe with as little as €7 Every single contribution of yours helps us guarantee our independence and sustainable future we can keep on providing constructive reporting on the developments in the region give even more global visibility to our ecosystem and educate the next generation of innovation journalists and content creators Find out more about how your donation could help us shape the story of the CEE entrepreneurial ecosystem START HERE You can also support The Recursive’s mission with a pick-any-amount DONATE NOW 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Some are necessary and we can’t switch them off Others help us to provide you with the best possible service We use cookies to personalise content and ads to provide social media features and to analyse our traffic We also share anonymous information about your use of our site with our social media By accepting cookies you will be helping us to continue to provide you with the best possible service CDP Access has been confirmed as the dealer for Klubb in Romania Apart from being the largest aerial platform rental company in Romania CDP Access has more than 20 years’ experience in the industry CDP was also the first company in Romania to distribute access equipment in the country when it made the move to replace traditional scaffolding in the construction sector “During our first meeting in Paris we visited the Klubb factory and were very impressed by the general atmosphere inside the company the quality of the production area and of course by the energy of the team which we feel is ideal for the Romanian market.” “The highly relevant experience of CDP Access placed them as an innovator with a strong service network in Romania It’s exactly the type of profile that we need as a partner for Klubb.” as well as focusing on mutual growth for both companies in Romania This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page The project will cover an area of 12,000 sqm and will include three outdoor tennis courts, two paddle tennis courts, a leisure pool and a 2,000 sqm building that will house a semi-Olympic swimming pool, a spa and a fitness room. „We are always happy to join Alesonor in projects that build a more sustainable and better future for generations to come Sport is increasingly important in an age where sedentary home working isolation and rare outdoor activities have become a way of life We thank them for the opportunity to contribute to the implementation of these projects that improve the quality of life” partner and head of the Real estate practice at Filip & Company The Filip & Company team that provided legal assistance in this project was coordinated by Ioana Roman (partner) and included Mihaela Ispas (counsel) and Alexandru Popa (associate) We use cookies for keeping our website reliable and secure providing social media features and to analyse how our website is used [Written by Stephen Wright] Andre Lambe is in a confident mood ahead of his regional title fight against Canadian Paul Ispas at The Shed in Dockyard next Saturday [October 22] aiming for a sixth successive win in the professional ranks is challenging fellow southpaw Ispas for the vacant American Boxing Federation regional welterweight title including a pair of draws against compatriot Cody Kelly who takes on Bermudian Nikki Bascome in the main event of Fight Night Champion Lambe will step up from four to six rounds and has sparred exclusively with Bascome to prepare for the biggest fight of his fledgling career “My approach for this fight hasn’t changed at all,” Lambe told Bernews and it was just a case of getting the fights in so I’d be ready to step up [to six rounds] I’ve got some great sparring with Nikki [at the NB Boxing Gym in Warwick] The 27-year-old said he has not poured over video footage of Ispas preferring to study his strengths and weaknesses after the opening bell as opposed to someone with just brute force I might need a little more time to figure him out,” said Lambe who enjoyed a stoppage win in his previous outing against Jamaican Dwayne Lawrence in June I’ve been pretty good at figuring guys out and I know I can keep the intensity I bring throughout six rounds “I’ve seen bits of his [Ispas] most recent fight but I let my coach [Pelon Andrade] do all that I don’t like preparing for what I’ve seen online; I prefer to wait and see what I find on the night Welterweight Bascome [10-1-0] will also face a southpaw in 34-year-old Kelly Kelly has fought Bascome’s previous opponent Dylan Rushton twice winning by a unanimous decision in February and drawing against his fellow countryman in January 2019 Bermudian Michael Parsons meets Jamaican Gregory Miller in a super-welterweight contest Tickets are available at Choices Menswear and ptix.bm Ringside seats cost $150 and include VIP entry #Boxing #StephenWrightReports Category: All, Sports Sign in Join now, it's FREE! “Marvelous” Mark Smither lived up to his nickname this weekend The Barrie resident and professional boxer took to the ring at the CAA Centre in Brampton where he fought his way to a unanimous decision to win the Canadian Super Lightweight title against Paul Ipsas Saturday night Smither’s first professional championship title which keeps him undefeated so far in his professional career “I had a good performance Saturday night and we got the title,” he told BarrieToday on Monday adding the win makes him the first Canadian pro champion for Barrie.  Smither admits he was definitely feeling some nerves “I was just nervous because I’ve worked so hard for this I wanted to win it so bad that I was high on the nerves but I used that to my benefit and I ended up getting the job done,” he said “All the 15 years of being in the gym… everything just paid off I’ve never missed a long time from the boxing gym always trained my hardest and I gave it my best shot… and we came out victorious." Smither admitted it is a good feeling to know he will be going down in the sports history books with some of the country’s greatest including George Chuvalo and Tommy Burns where it will stay until he moves into his new home and is able to find the proper place of honour there Smither called Ipsas “one hell of a fighter” adding he has nothing but respect for his opponent As for what’s next for the new champ however Smither is hoping to bring a fight to Barrie’s Sadlon centre this summer More Spotlight > Law firm Tuca Zbarcea & Asociatii has appointed four partners and seven senior associates in its annual round of promotions The appointments are effective from January 1 The firm has added four partners to its ranks while promoting seven other lawyers in its Bucharest office in a bid to further strengthen the firm’s Banking and Finance The firm’s new partners are Gabriela Anton, Oana Gavrila, Horia Ispas and Anca Puscasu, all lawyers with extensive experience in the profession, which they combine with strong leadership and project management skills gained in their capacity as members of the firm’s elite group of Managing Associates over the past few years. The firm separately promoted seven lawyers to the role of Senior Associate has more than 15 years of experience in the legal profession and specialises mainly in banking and finance and mergers and acquisitions in the banking sector and other international financial institutions such as project finance and corporate finance in various industries She has also been involved in mergers and acquisitions restructuring projects and the transfer of banking assets Her other areas of practice are corporate and commercial law Gabriela Anton graduated from the Faculty of Law at the University of Bucharest and the College of Law for European Studies of the University of Paris I Pantheon Sorbonne in 2000 Horia Ispas is a Partner in the firm’s corporate and mergers & acquisitions practice groups he has advised on private mergers and acquisitions as well as privatisation projects involving major state-owned companies having drafted and negotiated the underlying documentation such as shares sale and purchase agreements He also has a vast experience in complex corporate operations including specific operations of companies listed on the capital market Other areas of particular focus for him are personal data protection and consumer protection Horia Ispas has graduated from the University of Bucharest’s Faculty of Law in 2003 and has been a member of the Bucharest Bar since 2004 He is a Certified Expert in European Structural and Cohesion Funds providing social media features and to analyse how our website is used.