NY  — The Endometriosis Foundation of America (EndoFound) and Cold Spring Harbor Laboratory (CSHL) announce the launch of the Seckin Endometriosis Research Center for Women’s Health a new initiative dedicated to advancing research and discovery in endometriosis The center is funded through a combined $20 million commitment—$10 million from EndoFound and a $10 million matching gift from CSHL Board Chair Marilyn Simons This marks a historic investment in one of the most overlooked areas of women’s health research aiming to accelerate scientific breakthroughs and improve the lives of those living with endometriosis The Seckin Endometriosis Research Center will be housed at Cold Spring Harbor Laboratory and led by Dr whose work explores the intersection of genetics and the immune system in female reproductive health Named in honor of internationally renowned endometriosis surgeon Tamer Seckin the center will apply advanced technologies and interdisciplinary collaboration to investigate the disease’s underlying biology Seckin is known for developing the patented blue dye technique that helps surgeons detect otherwise hidden lesions improving both diagnosis and surgical treatment outcomes Endometriosis is a chronic disease that occurs when tissue similar to the uterine lining grows outside the uterus though it can also appear elsewhere in the body It affects approximately 1 in 10 women of reproductive age and is a leading cause of infertility endometriosis research remains severely underfunded The Seckin Endometriosis Research Center will serve as a hub for scientific collaboration Its mission is to deepen understanding of the disease and ultimately drive the development of better diagnostics and treatments To learn more or to support this initiative, visit https://www.endofound.org/seckin-endometriosis-research-center About the Endometriosis Foundation of America Eight Years After Experiencing Her First Endometriosis Symptoms at Age 35, Alexis Roderick Joel Has Reclaimed Her Life With every gift to the Endometriosis Foundation of America YOU help support our mission of increasing disease recognition and funding landmark endometriosis research Endometriosis Foundation is a registered 501(c)(3) non-profit organization as determined by the Internal Revenue Service under EIN 20-4904437 Gifts are tax-deductible to the extent allowed by law Home / News / CSHL Stories and Media From being told that their pain is not real to facing the heartbreak of infertility and even the threat of death, women dealing with endometriosis face incredible, sometimes lifelong journeys that can be rife with suffering and uncertainty. Now, Cold Spring Harbor Laboratory (CSHL) is partnering with the Endometriosis Foundation of America (EndoFound) to bring more research to bear on this disease which affects approximately 200 million women worldwide EndoFound has committed $10 million to CSHL to establish the Seckin Endometriosis Research Center for Women’s Health. Tamer Seckin Founder and President of the Endometriosis Foundation of America Founder of the Seckin Endometriosis Center Clinical Professor of Obstetrics and Gynecology at the Zucker School of Medicine at Hofstra/Northwell and Attending Physician at Lenox Hill Hospital announced the commitment at a ribbon-cutting ceremony held at CSHL EndoFound leaders and CSHL scientists in attendance expressed tremendous enthusiasm and confidence that EndoFound’s transformative pledge would not only lead to new diagnostic and therapeutic advances for endometriosis but also promote awareness of the disease “Imagine having to endure pain levels at or near those experienced during childbirth—every single month for most of your life That is the reality for millions of women and girls living with endometriosis,” said Dr Founder and CEO of Celmatix Therapeutics and EndoFound Board Chairperson often debilitating disease where tissue similar to the uterine lining grows outside the uterus typically in but sometimes beyond the pelvic cavity It can begin at first menstruation and persist through menopause “I have dedicated my life to understanding endometriosis a disease that affects more than 200 million women worldwide,” said Seckin “The establishment of the Seckin Endometriosis Research Center for Women’s Health at Cold Spring Harbor Laboratory marks a truly historic milestone—the first dedicated endometriosis research center within a premier U.S “For all the women who have suffered silently and been overlooked for far too long, we dedicate this Center to you,” Seckin continued. “My deepest gratitude to Alexis Joel for speaking so beautifully about her own experience. Thank you to Dr. Semir Beyaz the generosity of Madeleine Rudin and our donors and patient who made this moment possible.” The Seckin Endometriosis Research Center for Women’s Health provides a state-of-the-art lab and additional resources for a CSHL program that seeks to uncover the biological markers of endometriosis and novel drug targets for the disease EndoFound’s $10 million commitment is being matched for a $20 million total commitment to the establishment of the Center “The major goal of this Research Center is to interrogate the complex genetic and environmental determinants of endometriosis,” said CSHL Assistant Professor Semir Beyaz, who leads the endometriosis research program at CSHL “We will investigate the precise molecular and cellular mechanisms underlying endometriosis to develop preventative “This commitment is more than just a major show of support It is truly transformative,” added Marilyn Simons CSHL Board Chair and co-founder of the Simons Foundation “I am confident that the studies conducted at the Center will have significant implications for women’s health I thank EndoFound for their powerful vision and commitment which we expect to inspire increasing support of endometriosis research and education at CSHL and across the globe.” Written by: Lisa Cruz, Vice President, Communications | cruz@cshl.edu | 516-367-6846   Newsletter Signup   Donate Now   Newsletter Sitemap | Privacy Policy | Web Accessibility A women’s health research center focused on endometriosis opened Thursday at Cold Spring Harbor Laboratory hoping to unravel the mysteries behind the painful disease that impacts millions of women every year The Endometriosis Foundation of America said it is committing $10 million to the center which will put the spotlight on a condition that has traditionally not received the kind of attention or funding awarded to other health issues chair of the Cold Spring Harbor lab’s board Endometriosis causes tissue similar to the lining of the uterus to grow on other organs such as ovaries bowels or bladders in women of childbearing years according to the Centers for Disease Control and Prevention has been researching what causes endometriosis and how it develops by examining genetic environmental and lifestyle-related factors "This will allow us to do the research that has not ever been done before which is the foundational work across different patient groups," Beyaz said "If you don't understand the mechanism Researchers said they can take healthy cells and transform them into diseased cells to find better ways to diagnose and eventually develop treatments for endometriosis "We have resources here that we can deploy to endometriosis to potentially first understand it "Cold Spring Harbor is one of the forefronts in this molecular and genetic research that we historically applied to other diseases like cancer." Women have said their chronic pain has been dismissed The Endometriosis Foundation of America said it takes about 10 years for a woman to receive a diagnosis because not enough people in the public and the medical community have a strong knowledge of the disease a gynecologic surgeon and pioneering endometriosis specialist who is the namesake of the Seckin Endometriosis Research Center for Women’s Health at Cold Spring Harbor Labs inflammatory disease that affects at least 200 million women around the world." who helped start the Endometriosis Foundation said he believes this is the first research center dedicated to the disease It will have the advantage of 30,000 specimens from patients that Seckin has collected to use for testing He urged women to advocate for themselves if they feel a doctor is not taking their complaints and symptoms seriously "Women should not accept what they hear from any doctor," Seckin said "They have to speak for themselves." Alexis Joel attended the event at Cold Spring Harbor Labs along with her husband, singer Billy Joel, and shared her own experience with endometriosis The Northport native fought back tears as she recounted how a long line of medical specialists and numerous health tests were unable to provide a diagnosis or ease her suffering Endometrial tissue growth is linked to a woman’s menstrual cycle and hormone fluctuations The tissue does not just appear on the reproductive organs but can be found in other parts of the body "I was begging doctors to help me," Joel recounted She said she finally found relief with Seckin Seckin removed 27 lesions during surgery on Joel "This is more than science," Joel said of the lab’s research "It's a pathway to an earlier diagnosis targeted therapies and personalized care for millions who have waited too long for answers." 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Get the latest news and more great videos at NewsdayTV Get more on these and other NewsdayTV stories The Newsday app makes it easier to access content without having to log in Unlimited Digital AccessOnly 25¢for 6 months the Cold Spring Area Chamber Golf Tournament occurs on Friday The Cold Spring Area Chamber of Commerce coordinates and hosts the tournament with annual locations rotating between Rich Spring and the nearby River Oaks Golf Course More: New Cold Spring store shares ‘glimmers’ of positivity with joyful gifts and art Organizers say they typically have approximately 25 teams and all 18 holes are sponsored by local businesses that provide fun games and activities at the holes A silent auction was held last year along with a 50/50 raffle “We partner with Schwieters Chevrolet (of Cold Spring) and offer a hole-in-one with a brand-new vehicle as the prize,” Cold Spring Area Chamber of Commerce Administrator Roseann Baisley told the Times “Other hole-in-one prizes in the past have included golf clubs We had a hole-in-one winner three years ago Money raised goes toward community events that the Cold Spring Area Chamber spearheads each year like Rock the River summer community concerts More: Cold Spring K-9 Officer Cash retires after 7 years of police service “The Chamber Golf Tournament is more than just a fun day on the course,” Baisley said “It is a valuable opportunity for networking This event brings together local businesses and community members in a relaxed setting where meaningful connections can be made You don't have to be a member of the Chamber to put together a team.” Those who sign their teams up by May 9 will be entered into a drawing for $150 cash Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application Landolfi was born to the late John and Mary (Musto) Landolfi on August 13 1937 at Butterfield Hospital in Cold Spring He passed away peacefully in his home surrounded by family on March 14 Ralph is survived by his devoted wife Mariann who were wed at Saint Francis of Assisi Parish on June 3 Richard and Sharon Maurice and Ralph Manzoeillo Ralph was predeceased by his sister Mary Manzoeillo Ralph attended Our Lady of Loretto Catholic School and graduated 8th grade and then went on to Haldane where he graduated in 1954 He took pride in the fact that each of his children and grandchildren followed in his footsteps He loved going to Haldane for their many sporting events he joined the United States Army to serve his country He shared many stories of his time overseas throughout Europe he spent 36 years in a fruitful career at IBM until he retired in 1992 He started his second career in working for the Village of Cold Spring Highway Dept where he worked for 10 years with many great people Ralph was a parishioner at Our Lady of Loretto parish and member of the #536 council of the Knights of Columbus He also held many active roles in the community that were dear to him He was a volunteer for the Cold Spring Fire Department where he held many firematic roles including Chief and President Ralph was also a former trustee for the Village of Cold Spring He took great pride in the celebrations of this community especially in his role as a chairman to the recreation committee for many years He never missed a chance to wave the American flag at a parade on Main Street or partake in a celebration at the riverfront In addition to his dedication to the Village of Cold Spring he served as the Putnam County Fire Coordinator He was adored by many friends in the community and could be seen on Saturday mornings sipping coffee with the Cold Spring “old timers” 2025 from 4-7 pm at the Clinton Funeral Home 21 Parrott St Cold Spring NY A Mass of Christian Burial will be held at Our Lady of Loretto Church 24 Fair St Cold Spring Jude or Our Lady of Loretto parish in Cold Spring NY Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors CSHL Professor David Tuveson and Research Investigator Claudia Tonelli have found a way to “intercept” pancreatic cancer they were able to prevent pancreatic cancer from forming in the first place Pancreatic cancer is projected to become the second-deadliest cancer by 2030. By the time it’s diagnosed, it’s often difficult to treat. So, for both individual patients and the general population, fighting pancreatic cancer can feel like a race against time. Cold Spring Harbor Laboratory (CSHL) Professor and Cancer Center Director David Tuveson offers a telling analogy: But some of your moles you have a dermatologist looking at to make sure it’s always fine They may take it out and send it to the pathologist to ask Imagine that in your pancreas—because that’s the reality We all have early versions of cancer in many tissues at all times.” Now imagine treating those “early versions” in the pancreas—before they become cancerous. A new discovery at the CSHL Cancer Center could help make this possible Tuveson and Research Investigator Claudia Tonelli have found a way to effectively “intercept” pancreatic cancer we need to first understand a little bit about pancreatic cancer genetics “Over 95% of pancreatic cancer patients have mutations in KRAS,” Tonelli explains. “It’s the driving oncogene in this disease. We discovered that another gene, FGFR2, plays a role in enhancing mutant KRAS signaling in pancreatic cancer. When that happens, those ‘early versions’ of pancreatic cancer become much more aggressive.” Tonelli and Tuveson observed this outcome in mice and organoids—lab-grown versions of human pancreatic tissue the researchers weren’t just having a look Their goal was to stop the pancreatic tissue from becoming cancerous Because FGFR2 is a known oncogene in other cancers several inhibitors are already used in the clinic today When Tonelli and her colleagues inhibited FGFR2 at precisely the right moment When they targeted FGFR2 along with EGFR—a protein known to be overactive in pancreatic cancer—they saw even better results Fewer “early versions of cancer” formed in the first place “With an increasing number of FGFR2 inhibitors entering the clinic our study lays the foundation to explore their use in combination with EGFR inhibitors for pancreatic cancer interception,” Tonelli says Patients with a family history of pancreatic cancer would likely be among the first candidates to receive such treatments For now, fighting pancreatic cancer remains a race against time the day may soon come when time is on our side Written by: Samuel Diamond, Editorial Content Manager | diamond@cshl.edu | 516-367-5055 Tonelli, C., et al., “FGFR2 Abrogation Intercepts Pancreatic Ductal Adenocarcinoma Development”, Cancer Research, April 2, 2025. DOI: 10.1158/0008-5472.CAN-24-4576 Zuckerberg Professor of Cancer ResearchCancer Center DirectorM.D. Cold Spring Harbor Laboratory (CSHL) got a generous spring refresh this March thanks to the local nonprofit, Long Island Arboricultural Association (LIAA) and landscape professionals from across Long Island volunteered their time and expertise to prune and tend to trees across CSHL’s 120-acre campus Some of these giants are over a century old “I was honored when the LIAA approached me about hosting the Arbor Day event,” said CSHL Assistant Director of Buildings and Grounds Danny Miller “The Grounds Department schedules tree maintenance regularly We are thankful for the LIAA and all the members who volunteered their time.” In addition to preserving the campus’s beauty regular maintenance is needed to help remove potential hazards The spring refresh also allows healthy plants to thrive “The LIAA has been around for more than 50 years and this event in particular dates back nearly to the beginning of the Association,” said LIAA President Joseph Patrone “Giving back to the community and being able to highlight the abilities of the arboricultural industry is always of utmost importance to the Association and its members that commitment was reinforced through the generosity of the LIAA Written by: Caroline Cosgrove, Community Engagement Manager | cosgrov@cshl.edu | 516-367-8844 From March 26–29, 2025, Cold Spring Harbor Laboratory’s Center for Humanities & History of Modern Biology, in collaboration with the CSHL Meetings & Courses Program, hosted Cancer Genetics: History & Consequences The extraordinary international gathering brought together the field’s pioneers with today’s leading innovators and future trailblazers attendees were immersed in a rich historical journey tracking cancer genetics from its earliest discoveries to its most promising frontiers The meeting opened with personal reflections on foundational discoveries Speakers offered firsthand accounts of monumental breakthroughs like the identification of reverse transcriptase Hear from cancer genetics’ leading voices Brian Druker as well as meeting co-organizer Mila Pollock Talks moved seamlessly from past to present spotlighting other landmark moments such as the discovery of oncogenes BRCA1 and MYC the unraveling of signaling pathways Ras and Wnt and the development of revolutionary technologies like single-cell sequencing and CRISPR The scale of progress was impossible to miss One presenter pointed out that genetic analysis has moved from poring over charts that spanned entire hallways to sequencing whole genomes in a matter of hours It was a potent reminder of how far the field has come to the point where therapeutic strategies once considered theoretical now drive personalized approaches to cancer medicine Their talks were reflective and often emotional as they spoke not only of scientific triumphs but also of the collaborations ​​For CSHL graduate students in attendance it was like hearing knowledge come to life “It’s hard to stay in the lab,” said one Ph.D “when the people who wrote the textbooks are talking down the street.” Moments like these captured the spirit of the meeting—a rare convergence of past Talks also honored those who could no longer be here in person. “There is such a thing as scientific immortality,” said Mary-Claire King very good representation of how those of us who are still here are able to make that happen.” And though the meeting explored history, its focus extended from today to tomorrow. A special evening panel, moderated by physician-scientist and author Siddhartha Mukherjee and ethical implications of cancer genetics poster sessions buzzed with new research on tumor evolution spotlighted visionary efforts to overcome drug resistance and develop new multipronged therapeutic strategies for aggressive cancers the meeting fostered vibrant dialogue—between scientists and historians It was a celebration not just of what we know but how we came to know it and where that journey might lead us next Written by: Emma Courtney, Graduate Student | publicaffairs@cshl.edu | 516-367-8455 Home / Giving / News Self-described serial entrepreneur Tom Milana was not expecting a routine doctor’s appointment to turn into a mission to educate men about health and wellness An early diagnosis and intervention meant Milana was cured but the path was set for Milana to establish what today has become a national charity saving men’s lives The Milana family is not new to philanthropy having established the Milana Family Foundation to raise money for children in need but Milana’s diagnosis shifted the family’s and the Foundation’s priorities “If you build a better experience for men at the doctor’s office, more men will focus on their health,” Milana explained. Hence, the birth of Man Cave Health The organization’s first project set out to create spaces in healthcare facilities that mirrored a men’s lounge with the goal of creating a comfortable environment for men to focus on their health The organization provides virtual support groups and resources and launched a new initiative in 2024 focused on early detection of prostate cancer “More than 30,000 men a year die of prostate cancer mainly because they find out too late,” Milana said Man Cave Health began offering mobile testing for prostate cancer and has tested more than 5,000 men several of whom discovered elevated prostate specific antigen levels which can indicate early signs of prostate cancer enabling earlier diagnosis and intervention Man Cave Health will operate three mobile testing units across the country with the goal of launching 25 units over the next five years providing “a welcoming space where men can access PSA tests judgment-free environment,” according to mancavehealth.org Milana is used to seizing on opportunities translating a background in finance into a successful restaurant business with five establishments on Long Island That propensity to continuously evolve has meant Man Cave Health is ever changing After a visit to Cold Spring Harbor Laboratory (CSHL), Milana saw how funding prostate cancer research in Professor Lloyd Trotman’s lab aligned with the nonprofit’s mission to empower men with the tools and resources needed to be healthy Milana and his wife Adriana are hosting a benefit concert this summer I knew we had to support his work,” Milana said Trotman has pioneered research in prostate cancer having generated a unique mouse model to test prostate cancer therapeutics and more recently developed 3-d imaging technology enabling researchers to visualize cancer and metastatic progression In October 2024, Trotman published a study that found the pro-oxidant supplement menadione slows prostate cancer progression in mice having been developed after a study that started in 2001 by the National Cancer Institute showed that antioxidants failed to treat prostate cancer and in fact made it worse Trotman thus tested the reverse theory that he now hopes to take into pilot studies with human prostate cancer patients “Our target group would be men who get biopsies and have an early form of the disease diagnosed,” Trotman says “We wonder if they start to take the supplement whether we would be able to slow that disease down.” has been working on prostate cancer for more than 20 years “Lloyd’s focus is on finding a way to reverse metastasis and on how nutrition and vitamins can impact cancer development,” Milana said Two Long Islanders are making a big difference in men’s health in their own way The work of Man Cave Health has meant better outcomes for men’s health nationwide Milana and his nonprofit could impact the lives of men and their families for years to come CSHL Associate Professor Tobias Janowitz and colleagues identified a circuit connecting the brain and immune system that may be responsible for the sense of apathy many late-stage cancer patients experience The discovery suggests that existing antibody treatments could be repurposed to improve cancer patients’ quality of life and enable them to better tolerate common cancer therapies “Many patients complain of symptoms in that category I don’t feel like eating it.’ Their grandchildren come for a playdate cachexia severely limits patients’ ability to tolerate common cancer treatments CSHL scientists have been studying the condition for years Janowitz and colleague Adam Kepecs at Washington University School of Medicine in St Louis (WashU Medicine) have identified a connection between the brain and the immune system that is responsible for cachexia-related apathy certain neurons release less and less dopamine Screening for elevated immune system proteins in the brains and bodies of mice with cachexia led the team to IL-6 which gets released during inflammation and has long been associated with cachexia Decreasing IL-6 signals in connected brain areas made the mice more motivated the mice became less sensitive to the amount of effort required to find food The scientists saw the same result when elevating dopamine levels in the right brain areas “We discovered a full brain circuit that senses inflammation in the bloodstream and sends signals that reduce motivation,” Kepecs says “This reveals that apathy isn’t just an emotional or psychological reaction to cachexia—it’s built into the biology of the disease.” The discovery further suggests that existing antibody treatments could be repurposed to improve cancer patients’ quality of life “Our goals are to make patients feel better and to treat the cancer better,” Janowitz explains “A better patient will be able to better tolerate and benefit from anti-cancer treatments.” Working across cancer and neuroscience has brought the researchers this far. Their ultimate hope is that one day, through continued interdisciplinary collaboration, they will help turn cachexia into a condition patients can overcome That would be a welcome development not only for people battling cancer but also for their loved ones who suffer alongside them Written by: Jennifer Michalowski, Science Writer | publicaffairs@cshl.edu | 516-367-8455 National Institute of Child Health and Human Development Taylor Family Institute for Psychiatric Research The Brain & Behavior Research Foundation Zhu, X.A., et al., “A neuro-immune circuit mediates cancer cachexia-associated apathy”, Science, April 11, 2025. DOI: 10.1126/science.adm8857 Associate ProfessorCancer Center Program Co-LeaderM.D. Home / News / HarborScope Blog By “It’s a nice base of operations,” says Trevor Christensen a CSHL graduate student living in Knight House “You have almost all the first-year students in Knight and across the street at Cutting It makes it pretty easy to get together for things like working on projects Current first-year resident Pablo Mantilla says: But the view is definitely my favorite thing In 2005, the Laboratory expanded its housing options across the harbor by purchasing and renovating a nearby home previously owned by former CSHL Association President George Cutting Cutting House was initially occupied by postdoctoral fellows SBS students work directly alongside CSHL scientists in a variety of fields Workdays often start early and can extend into the night and tests they expect to work on throughout the semester The availability of affordable student housing at CSHL means one less thing to worry about for Christensen and Mantilla “It’d be a lot harder to attend classes and work on projects if I didn’t live so close,” Christensen says affordable housing really gives you a solid foundation to build off of You’re living with people in similar situations you can rely on each other to help out with things.” CSHL has announced plans to expand housing availability for postdocs and visiting scientists through the Foundations for the Future campaign the effort will allow more scientists than ever before to share in the joy of discovery at CSHL It’s an experience Knight and Cutting residents already know well “It really feels like a different world,” Mantilla says “It’s like if somebody wrote a book about this place where people go to become scientists and let you focus on just being a scientist Cold Spring Harbor Laboratory’s (CSHL’s) Ludmila Pollock has been named a 2024 Fellow of the American Association for the Advancement of Science (AAAS) She is recognized for her efforts to promote the history and philosophy of science “It’s not important how many prizes I receive But if such an important organization as AAAS recognizes you it means you do really good work for researchers That acknowledgment is a tremendous honor.” and innovators for their efforts to advance science in service to society Pollock joins a long list of CSHL faculty members who have been named AAAS Fellows including President and CEO Bruce Stillman education program leaders David Stewart and Jan Witkowski and Professors David Jackson and Nicholas Tonks Written by: Nick Wurm, Communications Specialist | wurm@cshl.edu | 516-367-5940 It has abruptly lowered the Indirect Cost Rate to 15%—a huge reduction in support of research This will have a major negative impact on Cold Spring Harbor Laboratory (CSHL) but even more profound is the overall detrimental impact this Guidance will have on the entire infrastructure of bioscience impeding future medical breakthroughs and slowing economic growth and affecting thousands of jobs in bioscience The impact to Cold Spring Harbor Laboratory and other academic scientific research institutions is unsustainable CSHL is a 501(c)(3) nonprofit research and education institution that has shaped contemporary biomedical research and education with programs in cancer Our researchers work on diseases from Alzheimer’s and autism to rare childhood cancers and cancers that impact millions worldwide Discoveries at CSHL have resulted in the development of one of the most impactful treatments for breast cancer and a lifesaving treatment for spinal muscular atrophy (SMA) which was the leading genetic cause of infant death These are just a couple of the many incredible scientific advancements researchers are making here developed by a variety of bioscience associations Direct and indirect costs are both necessary expenditures for conducting cutting-edge scientific research Direct costs cover expenses such as researchers’ salaries and benefits and project-specific supplies and equipment support the true costs of research operations While indirect costs cover a portion of general administrative expenses (commonly referred to as business overhead) the vast majority of indirect costs are comprised of research operations costs including expenditures on scientific computing resources maintenance of laboratories and special laboratory mechanical growing regulatory compliance with federal and state regulatory guidelines Research requires an incredible amount of supplemental support that is simply not captured in direct research costs has long been the leader in scientific research and ultimately a loss of well-being in the nation’s health and economy To preserve and strengthen the United States’ competitive research advantage we should be looking for ways to provide more Home / About Us / Foundations for the Future Foundations for the Future is a visionary seven-acre expansion project dedicated to pioneering research in three critical areas that will shape the world of tomorrow Cold Spring Harbor Laboratory (CSHL) is already known across Long Island and worldwide as a leader in scientific discovery we are laying the groundwork for further innovation with the potential to improve countless lives will provide state-of-the-art facilities for cutting-edge research Phase II will expand our role as a global hub for scientific knowledge with a new Conference Center and Collaborative Research Center The expansion project is currently scheduled to run through Q4 2026 Construction will take place within the hours established under Village of Laurel Hollow regulations While we know there will be some effect on local traffic we will continue working with the community to help minimize this impact The project has a construction entrance on Rt We have staged flagmen in key areas to help control the flow of traffic and ensure your safety the construction area includes dedicated space to queue and park vehicles onsite All work is being performed in strict adherence with State environmental laws and Village building regulations. To prevent visual pollution, CSHL worked with the Village of Laurel Hollow to plant 350 8-to-10-foot-tall trees along the construction fence facing 25A and Moores Hill Road. As a further precaution, vibration monitors have been installed around campus and at neighboring houses. For more information, see our Safety & Sustainability FAQs CSHL and its building partners are taking a number of steps to promote a healthful and sustainable working environment The Neuroscience Research Center utilizes a high-efficiency exterior insulation and finish system This offers exceptional heating and cooling efficiency and provides superior insulation for enhanced comfort and sustainability The interior finishes also support building occupant health through improved air quality and acoustics while biophilic design principles seamlessly integrate the structure into its natural surroundings The NeuroAI Building employs an innovative approach to mass timber construction harmoniously uniting sustainably sourced cross-laminated decking and glue-laminated beams to reduce the structure’s carbon footprint This is achieved through the reduction of manufacturing emissions and the utilization of rapidly renewable materials for carbon sequestration These construction practices are projected to reduce CO2 emissions by 582 metric tons which is equivalent to taking 130 gas-powered vehicles off the road The architect of CSHL’s Foundations for the Future expansion project is Centerbrook Architects & Planners Centerbrook has worked with CSHL continuously since 1973 designing more than 50 projects on and off of our main campus CSHL has contracted the following firms to complete the construction project For more information on the Foundations for the Future project and its impact on our local community, please contact CSHL’s Public Relations team at 516-367-8455 or email foundations@cshl.edu. You can also find CSHL stories related to the Foundations for the Future on this web page—see News an innovative nonprofit that has sparked dramatic progress in research on Lou Gehrig’s disease Like the colorful bird and its tall tail feathers cancer biology can make for some eye-catching images Rockefeller University geneticist Jeffrey Friedman speaks about obesity’s causes and treatments at CSHL’s Brain-Body Physiology Symposium Thought leaders from around the world came together at CSHL to share and discuss the latest research in brain-body physiology CSHL President & CEO Bruce Stillman discusses our institution’s societal impacts and global connections as forces for further scientific progress Join New York Governor Kathy Hochul and CSHL President & CEO Bruce Stillman for an aerial tour of CSHL’s Foundations for the Future expansion project The funding will help pay for a new pancreatic cancer center—part of CSHL’s Foundations for the Future project The new assistant professor will study how our brains navigate a continuously changing sensory environment: His goal: build more sensible AI Cold Spring Harbor Laboratory revenues achieved their second highest level ever CSHL’s Foundations for the Future campaign will propel the institution’s bioscience research and education programs to new heights and maximal impact she was the daughter of the late Margaret and William McKenna She is survived by her husband of 61 years and two-time prom date as well as her brother Richard McKenna of Putnam Valley NY and her sister Margaret Schatzle of Cold Spring and Christopher (Megan) Shields of Cold Spring  Betty Ann graduated from Haldane High School in 1959 having grown up and raised her family just a few doors down from the school she spent many years caring for young children in Cold Spring She loved Cold Spring and retelling its many stories She spent lots of days taking her grandchildren to the tot lot and the river Every baby and puppy she met were quickly scooped into her arms and she never turned down a full cup of tea or a trip to Marshall’s Betty Ann and Packy enjoyed a lifetime of vacations and parties with family and close friends and international trips with the Kiefers and the Dillons especially Fourth of July at Toni and Joe DeMarco’s Betty Ann and Packy’s greatest days were spent holding hands on the couch with a good movie.  A Mass of Christian Burial will be celebrated on Monday 2025 at 11:00 am at Our Lady of Loretto Church Interment will follow in Cold Spring Cemetery One of Betty Ann’s greatest joys was cheering on Haldane’s Lady Blue Devils basketball team the family encourages donations to the Haldane Blue Devil Booster Club scientists agree that perception certainly dictates reality our brains build up a world based on what our senses detect these senses process environmental stimuli without us even realizing it the subconscious brain can pick up the rhythm of conversations or notice behavioral patterns that our conscious mind rarely pauses to consider How exactly our brain transforms sensory information into a ​​neuronal response remains a mystery Understanding this process could have huge implications for how therapists treat conditions ranging from autism to strokes and even traumatic brain injuries Research in this area could help improve artificial intelligence systems these systems are built on our understanding of how the human brain uses At Cold Spring Harbor Laboratory (CSHL), an energetic group of neuroAI researchers has been making exciting breakthroughs in the neuroscience of perception Their discoveries could open the door to more sensible AI and new therapeutic strategies Verbal communication is one meaningful way we make sense of the world. CSHL Assistant Professor Arkarup Banerjee has long been interested in how the auditory and motor systems work together to enable free-flowing conversations only 200 milliseconds (about one-fifth of a second) pass between when one person stops talking and another responds “Think of all that needs to happen in one-fifth of a second You need to hear and process the auditory input trying to understand what those words mean Then you need to decide whether you want to respond or not Then you have to plan for it and move your muscles appropriately in order to speak the words you want to say.” To better understand how this works in the brain, Banerjee focuses on a species of mouse that can “sing” uptempo duets. Alston’s singing mice take turns vocalizing with each other using songs that can last many seconds and may contain up to about 100 human-audible notes There are often only 200 to 300 milliseconds between each call and response—a pace similar to human conversation CSHL Assistant Professor Arkarup Banerjee demonstrates the abilities of Alston’s singing mice and discusses what they may be able to teach us about human communication Banerjee’s team measured electrical activity in the mouse brains and examined neurons in a region called the orofacial motor cortex to see what they could uncover about the rodents’ chatter the mice vary the length of their performances When examining their data, Banerjee and his colleagues found something unexpected. The mice’s neural activity seemed to “bend” time to help them generate songs of varying tempos and communicate more effectively Instead of processing time in even amounts like a clock the mouse’s brain measured time in relative intervals Their neurons slowed down or sped up the song’s tempo based on its length Human brains similarly bend time without us even realizing it An hour spent doing a boring task can feel much longer than an hour hanging out with friends this manipulation enables greater vocal flexibility “One reason we have a brain is because it allows flexibility in our behavior you have to choose a suitable behavior in a model system we work on vocal interactions in the singing mouse.” Banerjee says this research not only advances our understanding of hearing and communication It also offers a new framework for thinking about how the brain manages social interactions breakthroughs like this could one day inform speech therapy strategies for children with autism and people who have suffered from strokes or other brain injuries CSHL Assistant Professor Benjamin Cowley is trying to understand how our brain processes information from a different sense: our sight And he has a fascinating way of going about it Cowley builds AI-powered models to predict animal behavior Cowley’s research focuses on fruit fly brains which are built similarly to ours but much simpler Human brains have almost 100 billion neurons the fruit fly’s visual system must account for flight It can respond to a visual input in less than five milliseconds Cowley investigates how male fruit flies respond to visual cues from females during the courtship process. Courtship rituals are a serious affair for the little flies and vibrate his wings to perform a series of “love songs.” In the wild these displays last only around five seconds researchers can extend the “dates” to around 30 minutes For a fly that lives only about three weeks “This is like a month-long date at Starbucks,” Cowley says “That gives us a lot of rich data to be able to see this courtship behavior unfold.” In a recent study, Cowley and colleagues silenced specific visual neurons in male flies and trained an AI model to detect subtle changes in the animals’ behavior after they were presented with a female. The team conducted multiple rounds of experiments, silencing a different visual neuron each time until the model could accurately predict how a real-life fly would respond to its female companion The team figured out that flies process visual data using groups of neurons rather than a single neuron connecting each visual feature to one action That finding could mark a major shift in how we think about sight it’s still unclear just how the brain processes visual cues “How does a stimulus—an image—transform into this useful neural code What are the transformations that do that?” Cowley wonders “We don’t yet understand that in the fruit fly And we don’t understand that in the human visual system as well But we haven’t nailed down the exact computations.” CSHL Assistant Professor Benjamin Cowley explores the brain’s visual cortex through the eyes of the fruit fly Figuring out these computations could lead to incredible advances in AI models that process visual stimuli AI that can distinguish between tumors and noncancerous growths Other applications could be even closer in sight Think of AI systems that allow self-driving cars to respond to visual cues more quickly Cowley’s fruit flies could also tell us something about energy efficiency Consider that flies’ brains enable them to walk and escape predators—all using minuscule amounts of energy today’s AI is nowhere near that level of efficiency their work could one day enable us to build artificial sensory technologies that restore lost senses or even heighten our existing abilities But perhaps even more exciting are the questions that will be addressed along the way “Our brain is the seed of all our intelligence—all emotions The question then becomes: ‘How does a relatively small organ manage all of these complex and crucial tasks?’” For Banerjee “The answer lies in being able to understand how neurons in the brain connect to each other How does the electrical activity in the brain allow humans and other animals to do what they do It’s the grandest challenge in the universe.” and their colleagues are up for the challenge and excited to see where it takes them next Written by: Margaret Osborne, Science Writer | publicaffairs@cshl.edu | 516-367-8455 The award includes a $50,000 donation from the NAS to support neuroscience research at an institution of her choice Churchland has chosen to give it all to CSHL It was here that Churchland says she learned to “push the envelope of what’s possible” with powerful new tools and techniques for making measurements inside the brain and I feel so grateful to have had that time there,” she says the chance to give back is really meaningful to me.” Churchland first came to the Laboratory as a visiting scientist in 2009 at the invitation of CSHL Professor Tony Zador While her work up until then had focused on non-human primates there was a growing movement at CSHL and abroad to establish rodents as the preferred animal model for studying the brain few were bold enough to make that kind of change in their careers,” Zador says and she spent the summer learning to train rodents on the tasks required for her research and she decided to make the switch—a very bold move She joined the faculty in 2010 and became one of the early people to help define the field.” Mice are now widely considered the preferred models for human brain disorders. Chuchland’s early studies of sensory science helped move the field in this direction a new generation of CSHL neuroscientists is picking up where she left off The $50,000 donation will support Zarmeena Dawood, a young M.D.-Ph.D. student in CSHL’s Albeanu lab. Dawood focuses on how the brain processes smells. She is using BARseq to map neural connections from the olfactory bulb to the rest of the brain “I am very excited to receive this gift,” Dawood says “It’s so important to support students as we’re going through our training And that it came from someone who also studied neuroscience at CSHL makes it even more wonderful.” paying forward the fruits of her time at CSHL was a no-brainer “One thing that’s special about CSHL is their support for students to follow the scientific direction they’re excited about,” she says “That is a tremendous intellectual freedom to have I want that for the young scientists of the world The chance to play a small part in that makes me really happy.” Churchland will be honored in a ceremony on April 27 during the National Academy of Sciences’ 162nd annual meeting. The ceremony will be live streamed For science to positively impact the world, it must be shared. It must be circulated among scientists and communicated with the public. Over the past decade, the free online platforms bioRxiv and medRxiv developed at Cold Spring Harbor Laboratory (CSHL) have revolutionized how biomedical research is shared around the world Accelerating their success now becomes the mission of openRxiv bioRxiv was founded in 2013, and medRxiv in 2019 the preeminent preprint servers for biomedicine empower scientists worldwide to share their research fast and free of charge by posting thousands of studies each month openRxiv is dedicated to the long-term sustainability of bioRxiv and medRxiv and will ensure that these platforms continue to serve their purpose—communication at the speed of science “Sharing science with the public has been an essential element of the Laboratory’s mission for more than a century,” says CSHL President and CEO Bruce Stillman “Though bioRxiv and medRxiv are naturally evolving to become independent of CSHL the Laboratory believes strongly in their work and purpose I am excited to join the distinguished individuals who have agreed to become directors of openRxiv and to work with co-founders John Inglis and Richard Sever and their preprint team colleagues to advance the success of bioRxiv and medRxiv.” To find out more, read the openRxiv launch announcement and visit openRxiv online Cold Spring for Annella (Nell) Marie Bechtold at Benedictine Living Community - Cold Spring after a long battle with many health issues Relatives and friends may call from 4:00 - 7:30 p.m on Wednesday at the Wenner Funeral Home in Richmond MN to Andrew Merdan and Frances Reisinger as child number seven of eleven She graduated from Cathedral High School in 1965 MN until marrying Roger Bechtold on April 11 Roger and Nell became business partners with Roger’s brother and sister-in-law and started Overhead Door Company of St Nell then became a devoted mother and homemaker pouring everything into raising their four children caring for numerous pets and her extensive gardens Nell was involved with many activities including selling carnations on Mother’s Day serving as a Eucharistic Minister and by teaching youth religious education classes She was also a member of Mary’s Cenacle and enjoyed taking devotional trips with friends through JeriCo Christian Journeys She especially loved taking tropical vacations with Roger and embarking on road trips with her family Her love of travel was further fostered by hosting three foreign exchange students who she was able to visit in their home countries and Lucy Bechtold; siblings Charles (Sandy) Merdan Marita (Donald) Schwinghammer and Imelda (Donald) Allen She is preceded in death by her parents; siblings Judith Koska Memorials are preferred to the ROCORI Area Community Foundation which supports local non-profit organizations The family wishes to thank the many healthcare workers over the years for their compassion Mass of Christian Burial will be 1:30 p.m. on Thursday, May 8, 2025, at St. Boniface Catholic Church, Cold Spring for Annella (Nell) Marie Bechtold, age 77, who passed away on Saturday, April 26, 2025, at Benedictine Living Community - Cold Spring after a long battle with many health issues.\nRead More Cold Spring Harbor Laboratory researchers have found that smell and sound signals merge in the mouse brain’s hearing center influencing social behaviors like pup retrieval The discovery may lead to a better understanding of how neurological conditions such as autism affect a person’s ability to interpret social cues but you can’t smell the food cooking or hear the dinner bell “When we experience the world and interact with people, we use all our senses,” Cold Spring Harbor Laboratory Professor Stephen Shea says “That’s true for animals and humans.” However that’s not always the case in developmental disorders like autism These conditions can affect how the brain processes incoming information making it difficult to interpret the social cues that drive conversations Exactly how such signals mix and influence each other in the brain isn’t well understood. To shed light on the subject, Shea and graduate student Alexandra Nowlan traced how smell and hearing interact in mouse brains during a maternal behavior called pup retrieval “Pup retrieval is one of the most important things for mothers or caregivers It requires the ability to smell and hear the pup that may mean they merge somewhere in the brain One interesting thing we found was a projection from a location called the basal amygdala (BA).” the BA is involved in learning and processing social and emotional signals the team found that BA neurons carry smell signals to the brain’s hearing center they merge with incoming sound signals and influence the animal’s response to future sounds—like pups’ cries when Shea’s team blocked maternal mice from accessing smell signals their pup retrieval response almost completely broke down “We think what’s reaching the AC is being filtered through social-emotional signals from BA neurons,” Shea explains. “That processing can be impaired in autism and neurodegenerative conditions We think many parts of the brain participate in this behavior and that it’s very richly controlled.” Shea’s lab is now exploring how these brain regions connect and interact with one another Their work may lead to a better understanding of how autism can affect a person’s ability to interpret social cues “The idea that we found a neural circuit that may allow emotional processes to directly interact with perception is very exciting to me,” Shea says His research might yet provide answers to one of humanity’s oldest questions How do our senses inform the ways we connect with one another and experience the world Nowlan, A.C., et al., “Multisensory integration of social signals by a pathway from the basal amygdala to the auditory cortex in maternal mice”, Current Biology, December 3, 2024. DOI: 10.1016/j.cub.2024.10.078 A unique shop in downtown Cold Spring aims to inspire and help people find creative gifts. Located on Main Street, Glimmer offers a wide array of gifts Owner Malissa Mauricio — an Iowa native who moved to Minnesota in 2010 — opened Glimmer last November after spotting an ideal location next to the Cold Spring Bakery “I took the idea back to my husband and other family members as opening a unique gift store had always been a dream of mine and it was a great location and opportunity,” she told the Times More: Developer hopes to bring roughly 100 new housing units to Cold Spring Mauricio has more than a quarter of a century of business and sales experience from her corporate finance careers at U.S but she eventually found a passion for the field of positive psychology “One of the concepts that they talk about is a term called a Glimmer," Mauricio said They are defined as small moments of joy that can improve mental well-being I determined this would give the store the name to fit the message the store stands for.” The other part of the business plan she developed was creating a space for local artisans to share their wares More: Healing with light: Lindsey’s Light Lounge in Cold Spring offers healing therapy “I quickly reached out to friends that I knew that were doing art fairs and asked if they would like to be a part of the journey,” Mauricio said “I had early partners in fellow moms in the community or that I knew personally and many were from our relationship to the families we had met through the River Lakes Hockey program.” Mauricio said some who played integral roles in the store's early successes are Christensen Customs “Having these artisans in shop gave me the opportunity to pay it forward twice in the community," Mauricio said "We've since added additional artisans from my community and are growing organically." Goals moving forward for the store are to continue to have a positive impact on others educate people about Glimmers and help "them find those glimmers through something physical they may see in the store.” More: Backwards Bread connects to St. Cloud community through baked goods Mauricio says that alongside “gentle reminders that sometimes bad days are simply bad days and not a bad life,” the aforementioned ideas have been the most rewarding part of her journey since November “The stories that people tell me when they see an item that spurs a memory or the laughter I hear as people are walking by reading funny shirts brings me joy,” she explained Mauricio hopes to be a staple in the community and eventually spread Glimmer more broadly to other small communities in either Minnesota or Iowa The brain controls the body, in large part, through nerves. So, what happens when nerves form new connections with tumors? How does the nervous system drive cancer progression? How do these interactions influence anti-cancer therapies? A burgeoning new field known as cancer neuroscience aims to answer these questions How does one solve a problem when the techniques for investigating that problem haven’t yet been established How can today’s cancer neuroscientists formalize their new knowledge so that it can be shared with others in and around the field CSHL’s Methods in Cancer Neuroscience is the burgeoning field’s first-ever hands-on course is one of four instructors running the course Joining him are Moran Amit from the University of Texas MD Anderson Cancer Center Ece Eksi from Oregon Health and Science University and Paola Vermeer from the University of South Dakota and Sanford Research There aren’t any formal degree programs yet,” Amit says it’s great seeing how excited people are to come here and make the effort to learn.” “I’ve learned so much already,” says Cecilia Pazzi, a student from the VIB-KU Leuven Center for Cancer Biology in Belgium. “It’s been fantastic. What I really like is that there is no distance between us and the instructors. We can ask whatever question we want, which helps with the learning process.” Such camaraderie is a central tenet not only of Methods in Cancer Neuroscience but all CSHL courses “The next four directors of this course are probably in the lab with us right now,” says Vermeer “They’re going to take what they’ve learned here There aren’t many textbooks on cancer neuroscience. (In fact, Amit edited the first, published in 2023.) But in time, the “methods” established through this course may make their way into the widely influential journal Cold Spring Harbor Protocols, available online through CSHL Press the new body of knowledge will continue to grow in both size and reach A man was found dead in the upper Hudson Valley in what's considered the most challenging hiking trail in the tri-state area New York State Police and the New York State DEC both confirmed the death of a hiker in the upper Hudson Valley Forest Rangers responded to a call for an unresponsive subject approximately one mile up West Kill Mountain For all the news that the Hudson Valley is sharing, make sure to follow Hudson Valley Post on Facebook, and download the Hudson Valley Post Mobile App Forest Rangers soon found the hiker and confirmed he was dead First responders recovered and removed the body by 12:15 a.m New York State Police are continuing to investigate New York State Police say troopers arrived to Spruceton Road in the town of Lexington around 6:45 p.m A group of hikers found an unresponsive man on the Devil's Path Trail Police pronounced him deceased at the scene "No foul play is suspected," New York State Police told Hudson Valley Post in a press release Police identified the hiker as 54-year-old Linhu Jin of Palisades Park A cause of death hasn't been released he's survived by his wife and daughter The Devil's Path hiking trail is considered one of the more challenging hiking trails in the New York Tri-state area A man was found dead in the upper Hudson Valley in what's considered the most challenging hiking trail in the tri-state area.\nRead More For all the news that the Hudson Valley is sharing, make sure to follow Hudson Valley Post on Facebook, and download the Hudson Valley Post Mobile App Home / About Us / Housing expansion project: Wrexleigh Estate Cold Spring Harbor Laboratory (CSHL) has been at the forefront of scientific discovery contributing to major breakthroughs in cancer research CSHL is also home to a vibrant community of Ph.D CSHL’s historic home on the Gold Coast of Long Island helps to attract these researchers but housing remains limited CSHL is committed to providing not only a unique educational environment but an economical and supportive living environment CSHL offers housing to researchers in communities throughout the North Shore and each residence reflects the unique nature of the community in which it’s located CSHL purchased the Wrexleigh Estate at 57 Sandy Hill Road to serve the future of science while preserving Oyster Bay Cove’s rich history and natural beauty Learn more about plans to restore and renovate the nearly 12-acre property to its previous glory while providing shared living space for early career scientists in the video and fact sheet below CSHL Professor Zachary Lippman and postdoc Amy Lanctot have begun to uncover how DNA sequences known as cis-regulatory fragments control flowering in distantly related plant species Their findings could help future plant breeders and biologists produce more desirable crops Humans have appreciated the beauty of flowers for centuries flowers aren’t just aesthetically pleasing They also play a crucial role in plant reproduction UFO expression hinges on another complex process called cis-regulation And this one has remained a “black box” of plant biology research for years Now, using CRISPR gene editing, Cold Spring Harbor Laboratory (CSHL) Professor and HHMI Investigator Zachary Lippman and his colleagues have begun to uncover the ways in which fragments of non-coding DNA called cis-regulatory sequences dictate how Lippman says this work could one day help researchers make better decisions about which genes to manipulate for more desirable crops We chose this one because it was pretty clear it was going to have that kind of exquisite control That’s because the flower is a complex structure and the genes that control its development are very regulated in time The researchers focused on two distantly related flowering plants: tomato and Arabidopsis they identified DNA sequences that don’t code for proteins but are still present in the segment of DNA that turns UFO on and off in both plants The mere fact the sequences are conserved makes them good candidates for targeting “It’s a good indication that those sequences have been selected by evolution because they’re important in controlling gene expression.” However “You can’t know until you actually do mutations in those sequences and see what happens.” “It’s fascinating that different deletions had opposite effects on flowering,” says CSHL postdoc Amy Lanctot “It seems these sequences act together to balance each other out and make sure plants are flowering at the right place and time.” The finding could help biologists better understand how cis-regulatory fragments control gene function “The goal is to reach a better understanding of how functionally complex cis-regulatory DNA is,” Lippman says we can better determine which sequences we want to mutate and what kind of mutations we want to make.” Lanctot, A., et al., “Antagonizing cis-regulatory elements of a conserved flowering gene mediate developmental robustness”, PNAS, February 18, 2025. DOI: 10.1073/pnas.2421990122 Professor & HHMI InvestigatorJacob Goldfield Professor of GeneticsDirector of Graduate StudiesPh.D. Watson School of Biological Sciences at Cold Spring Harbor Laboratory More than two million new cases of cancer will be diagnosed in the United States in 2024 according to the National Cancer Institute Range Cancer Therapeutics ETF (Nasdaq: CNCR) is partnering with Cold Spring Harbor Laboratory (CSHL) to highlight CSHL’s pioneering role in advancing cancer research 23% of revenues generated by fees from CNCR will be donated to CSHL quarterly Bringing together the powers of philanthropy and investing Range ETFs and CSHL announced this unique affiliation with a historic event at the Nasdaq stock market on November 14 The event featured a powerful visual display on the Nasdaq tower and Range ETFs and CSHL leadership and guests gathered on the iconic Nasdaq podium to mark this momentous occasion “Cold Spring Harbor Laboratory is one of only seven national basic biological research cancer centers designated by the National Cancer Institute in Washington DC Cancer research is fundamental to our discovery efforts,” said CSHL President and CEO Bruce Stillman “The institution is investing heavily in the growth of our cancer program collaborative ventures as part of our new brain-body physiology initiative.” Range ETFs CNCR ETF focuses on companies dedicated to cancer research offering investors targeted exposure in this vital sector It is purpose-built to provide exposure to a wide range of cancer therapeutic modalities “The contribution from Range will directly benefit the research efforts at CSHL underscoring our commitment to advancing scientific innovation in oncology therapeutics,” said Range ETFs founder and CSHL Association Board Member “CNCR ETF provides exposure to nearly the entire lifecycle of drug development and distribution and this new collaboration with CSHL provides an opportunity for investors to also see their money go toward the earliest stages of cancer breakthroughs.” Stillman added that unique partnerships like this provide opportunities to engage with people who are already committed to scientific advancement and maximize efforts to support cancer research in unique ways There is no guarantee the Fund will achieve its stated investment objectives Its concentration in an industry or sector can increase the impact of the risks from investing in those industries/sectors is the parent of Range ETFs (rangeetfs.com) a dedicated life-cycle investment platform for exchange listed funds Tim Rotolo is the Founder and CEO of Range Fund Holdings He is also founder and CEO of Lloyd Harbor Capital Management Home / News / Podcasts / At the Lab Each episode features a CSHL researcher or educator focused on the biggest global issues and scientific mysteries of the past and future—from deadly diseases to climate change Tune in to hear our latest bioscience breakthrough broken down in 3 minutes or less What happens to our brain receptors’ “dance routines” when the brain comes under immune system attack Transcript » Transcript » A tale of passion and curiosity takes us from New York to Australia Transcript » we sit down with CSHL Professor Lloyd Trotman to discuss what could be a major breakthrough in men’s health Transcript » This season’s final Research Rewind brings us from the realm of quantitative biology to neuroscience Transcript » we’re hacking it with the help of Cold Spring Harbor Laboratory’s geneticists Transcript » We probe each of these questions with the help of Cold Spring Harbor’s neuroscientists Transcript » As the first season of our new podcast winds down we’re revisiting all of our episodes with a focus on CSHL’s cutting-edge cancer research Transcript » a catalog of more than one million genomic variants Transcript » Cold Spring Harbor Laboratory solves a plant biology mystery some 4,000 years in the making The implications may go far beyond vegetables Transcript » Cold Spring Harbor Laboratory’s (CSHL’s) Ishana Chadha and Keita Takahashi have been named among the top high school scientists in the country about 2,500 high school seniors compete in the Regeneron Science Talent Search These teenagers represent the future of science study how neurons migrate in the brain and settle in different layers of the cerebral cortex “I’m really grateful to be part of a group of students who care so much about science Conducting research at CSHL and seeing everything come together and the impact of my work was one of the most amazing experiences of my life.” “You always want to keep it realistic with these things but I had a feeling she would go far in the competition,” he says Takahashi, a Partners for the Future (PFF) student in CSHL’s Jackson lab, earned a spot in the top 300 These scholars and their schools are awarded $2,000 each He is the fifth PFF student to be named a Regeneron Scholar since 2021 studied a protein called KN1 and related RNA which play an essential role in healthy plant stem development “It was crazy hearing the announcement,” says Takahashi “This was my first time working in a professional lab and the PFF program helped me connect with so many friendly people at CSHL It’s really preparing me for the next level “I was really happy and proud when I heard the news,” Gleason adds “It was a lot of fun preparing the project and working together with Keita It was a great learning experience for both of us.” The Stearns County Sheriff's Office sent a SWAT Team to Cold Spring Wednesday Authorities arrested a 24-year-old man on a felony domestic assault warrant for a prior strangulation offense He was arrested without incident at the address identified by the Stearns County Sheriff's Office Warrant Task Force A release states further investigation gave probable cause to charge the man with an additional charge for violating a domestic abuse no contact order Cloud Community Response Team and Mayo Ambulance assisted in responding The Stearns/Benton SWAT Team executed the warrant Corey Schmidt covers politics and courts for the St Hornell's pursuit of its first New York state championship was one quarter short. The Red Raiders were downed by Cold Spring Harbor-VIII 54-50 on Saturday in the NYSPHSAA Class B championship game Hornell led by as much as 17 in the second quarter and 15 in the third but were outscored 22-8 over the final eight minutes as the Seahawks completed the comeback Hornell started 8-for-20 from distance in building its lead but missed its final three tries in the fourth received four 3s from Ryan Reynolds in the fourth to close the double-digit gap When Reynolds fouled out with three minutes remaining Olivia Mulada took over and scored the game-deciding basket with 31 seconds remaining Jordyn Dyring led Hornell with 16 points and five rebounds She was the only Red Raider to reach double figures six rebounds) and Raegan Evingham (six points 11 rebounds) were the other major contributors Hornell (22-4) finished 4-for-12 from the free throw line including four straight misses in the fourth quarter The matchup pitted two teams that had never previously appeared in a state championship game had never reached a state tournament prior to 2025 Hornell vs. Cold Spring Harbor: Game startThe Seahawks win the opening tip Mia Nasca's 3-pointer is the highlight so far for the Red Raiders Cold Spring Harbor's Ainsley Dircks scores at the buzzer after a Hornell turnover But Hornell has held the Seahawks to 2-for-18 shooting so far Jordyn Dyring leads the Red Raiders with five points through eight minutes Raegan Evingham and Jordyn Dyring have back-to-back 3-pointers while Raegan Evingham has six points and seven rebounds so far for Hornell Cold Spring Harbor has racked up 14 offensive rebounds so far but struggling to finish on the second and third chances The Seahawks are shooting only 7-for-36 from the field so far Seahawks' basket trims Hornell's lead to single digits for the first time since early in the second quarter Hornell 42, Cold Spring Harbor 32: End of the 3rd quarterRed Raiders are eight minutes away from their first state title Difference so far is the execution from distance Hornell is 8-for-20 on 3-pointers while Cold Spring Harbor is only 1-for-16 Seahawks' Ryan Reynolds has two 3-pointers in the quarter to keep Cold Spring Harbor in it Six points is the smallest difference since midway through the first quarter which trailed by as much as 17 in the second quarter and 15 in the third Hornell behind for the first time this game after Olivia Mulada goes 2-for-2 from the line Red Raiders season ends in the Class B state championship Fashion and philanthropy came together to support crucial scientific research as Cold Spring Harbor Laboratory (CSHL) and the Penny’s Flight Foundation recently partnered with women’s designer clothing brand Veronica Beard for an exclusive in-person shopping event at the brand’s luxury storefront in Manhasset The event featured a sit-down discussion between CSHL’s Sarah Kitt and Penny’s Flight co-founders Kate and Chad Doerge who spoke about the power of private funding and raising awareness for fundamental biology research we have raised millions of dollars for NF research while inspiring countless individuals to join our fight,” said Penny’s Flight co-founders Kate and Chad Doerge we are funding innovative studies at leading institutions like CSHL and the Children’s Tumor Foundation—research that holds promise for transformative breakthroughs.” Penny’s Flight’s mission to advance research on NF1 and related disorders is inspired by the life and spirit of Penelope “Penny” Doerge, who passed away in November 2022. With a deep commitment to accelerating medical progress, the Foundation is also sponsoring an NF1-dedicated meeting at CSHL’s Banbury Center a leading think tank that specializes in bridging the gap between fundamental and translational research have attended more than 800 meetings held at the Center in Lloyd Harbor The Veronica Beard event demonstrated how partnerships bringing scientists and mission-driven brands together around a shared purpose can play a powerful role in driving progress As public support and private philanthropy continue to shape the future of science collaborations like this one remind us that meaningful breakthroughs often begin with a shared passion Penny’s Flight Foundation continues to soar above adversity,” said Kate and Chad Doerge we are making an impact that is felt across the NF community and beyond.” Cold Spring's local businesses are hosting a pre-Valentine's Day chocolate event on Friday The Cold Spring Chamber of Commerce is hosting its fourth annual Chocolate Crawl with free chocolate samples at 20 participating businesses from noon to 7 p.m The event will kick off at noon Friday with samples from businesses including Caribou Coffee Little Sisters Antiques and the Cold Spring Area Historical Society other spots like MN Brain Solutions and ARTess Experience Studio will join in the festivities Cold Spring light therapy: Healing with light: Lindsey’s Light Lounge in Cold Spring offers healing therapy and we appreciate people stopping by the businesses and hope that they would come back to support them as well," Cold Spring Area Chamber of Commerce Administrator Roseann Baisley said Local businesses will be handing out a range of treats from "chocoholic" ice cream and dirty sodas at Red Truck Ice Cream to mocha fudge sandwich cookies from Cold Spring Bakery Attendees can also sample mini Christine's Cheesecakes at ARTess Experience Studio Participants can also pick up an event passport at any of the participating businesses to keep track of the shops they visited Those who visit at least five businesses will be entered into the Valentine's Day-themed gift basket drawing Bonus entries will be available for purchases at participating shops Prom shop reopens: Carrie's Prom & Tux reopens after renovations just in time for prom season Baisley said the event is meant to support local businesses and introduce the community to stores they may be unfamiliar with do something fun and interactive in the community to try to get people to come out and see our businesses," she said "It is a really good way to get the area communities to get to know our businesses a little better." Additional information about the Chocolate Crawl and a copy of the passport are available on the Chamber of Commerce's website Teagan King covers business and development for the St known as Jerry to family and friends,was born on November 2 Jerry would often regale his children and their friends with stories from his childhood in Sunset Park.From stickball in the street and fountain sodas at the corner drug store to riding the Wonder Wheel on Coney Island Jerry was a captivating storyteller with an indelible memory Jerry attended Xaverian High School in Bay Ridge where he made lifelong friends and graduated from Villanova University with academic honors and a fierce allegiance (tested every March) to the Villanova Wildcats After traversing the Atlantic for a year with the United States Merchant Marine Jerry pursued graduate study in Clinical Psychology at Columbia University and St.John’s University where he earned his Master’s Degree In 1969,Jerry grabbed tickets to “some music festival upstate” out of a fishbowl on the counter of an East Village clothing store and ended up at Woodstock where he saw Carlos Santana perform and fell in love with the Hudson Valley Jerry would later move into the Valley and worked for many years at the New York State Office of Mental Health in Peekskill as a Clinical Psychologist Jerry was also instrumental in founding the Marriage and Family Therapy Graduate Studies program at Iona College where he taught and mentored students until his retirement in 2019 Jerry met Christine Schwartz at a work luncheon Theymarried in 1986 at the Chapel of Our Lady in Cold Spring and returned a few years later to settle in Lake Valhalla It is herethat they raised their three children- Brian and James- and have lived for the past 35 years Jerry was an active member of the Cold Spring community and served for over ten years as President of the Lake Valhalla Civic Association participated in the development of the Comprehensive Plan for the Town of Philipstown and served on the Board of the Putnam Highlands Audubon Society generosity of spirit and genuine love of connection meant he always had time for friends and strangers alike; he could never be rushed when the company was good Jerry’s most cherished role was that of father and grandfather Whether as a tee-ball coach for Philipstown Rec or a spectatorwatching his children and their friends compete for Haldane High School and later Jerry’sfamily brought him the greatest joy Jerry instilled in them a love for learning after a long and heroic battle with cancer He was surrounded and cared for by his loved ones up until his final moments and will be missed by many Jerry is survived by his siblings Peter and Carolyn (Richard)Rubino; his loving wife Christine and their three beloved children: Brian Lily (Robert) and James (Cara); sevenwonderful nieces and nephews and his two darling granddaughters: Amaryllis and Zinnia A Mass of Christian Burial will be held on Friday In Lieu of Flowers the family asks for donations be sent to the following ( Please Click the Link to donate ) 1. Putnam Highlands Audubon Society: https://www.putnamhighlandsaudubon.org/support-birds-nature/donate   2. Haldane Blue Devil Booster Club: https://www.haldaneschool.org/athletics/blue-devil-booster-club 3. Our Lady of Loretto Church: https://www.wesharegiving.org/app/giving/WeShare-20000184?tab=home   Home / Public Events / Event Calendar / Science on Screen Film: Gattaca Register/more info Tickets: Cinema Arts Centre Members and CSHL employees $11 |  General Public $16 co-presented with Cold Spring Harbor Laboratory where people’s worth is determined by their DNA defies his predetermined fate and embarks on a risky mission to join a prestigious space program secretly assuming the identity of a genetically superior individual he races against time to prove that destiny is not determined by genes but by human will After the movie, enjoy a live Q&A with CSHL Professor Dick McCombie who will discuss “The Ethics and Science of Genetic Engineering.” Explore how advances in genetics are reshaping medicine and consider the profound ethical questions surrounding our ability to alter life at its most fundamental level Visit: https://cinemaartscentre.org/ Register/more info anywhere from 40 to 80 percent of cases may be linked to genetic risk factors Studies suggest that viral infection in pregnant women may play a role why do some fetuses appear more vulnerable than others Today, answers are beginning to emerge. With the help of partners like the Simons Foundation, Cold Spring Harbor Laboratory (CSHL) has played a leading role in identifying autism’s genetic roots CSHL scientists are helping to explain how inflammation during pregnancy may lead to neurodevelopmental disorders in children Irene Sanchez Martin is a postdoc in CSHL Assistant Professor Lucas Cheadle’s lab She recently presented her research on maternal immune activation at a Society for Neuroscience press conference in Chicago She points to recent experiments in the Cheadle lab in which a mouse embryo may begin to show early signs of developmental deficits soon after its pregnant mother is exposed to a virus “The model we use is very well established for autism spectrum disorder,” Sanchez Martin explains “The difference in my work is that I check what happened to the fetuses 24 hours after exposure to maternal inflammation rather than analyzing the behaviors of the offspring as adults.” This is the first time scientists have been able to look at the effects of prenatal inflammation on an embryo in an autism model Such research may one day enable physicians to identify early warning signs before a child is even born Sanchez Martin will need to complete her research She’s just two years into her postdoctoral studies at CSHL her work is already producing exciting results while all female embryos appear to be protected from developmental deficits as many as one-third of the males are strongly affected This finding tracks with the long-held understanding that autism is more common in boys than girls There’s yet another question that will need answering What’s important is that each opens up new avenues of research And that means new opportunities to help improve the lives of expecting mothers as well as children with autism and their families Dozens of new housing units are coming to Cold Spring The Spartan Fields development is bringing 44 twin side-by-side housing units and 63 single-family homes to central Minnesota Cloud Times the 44 side-by-side units and one single-family home are part of a planned unit development that will have a homeowners association the remaining 62 single-family homes are in standard residential zoning and are not part of the homeowners association with construction expected to start within the next two months He said these units will likely be marketed this coming fall; however pricing details are still being determined More: St. Cloud, Stearns County sees slight property value increase with 2025 assessment "We don't have an exact price at this time," Bellmont said "We're still putting together the entire project which is why he picked the city as the development site The Cold Spring native owns three companies — Bellmont Homes Wausau Homes Cold Spring and Wausau Homes Monticello All three are the builders for the project Historic homes, rentals and crime: Inside St. Cloud’s south side university neighborhood Cold Spring City Council members unanimously approved the planned development during its March 26 city council meeting AccuWeather's long-range spring forecast was released today and if you were hoping for warm weather in the near future you'll likely be disappointed "Winterlike temperatures could linger well into the spring season in parts of the interior Northeast," the extended forecast states “Spring is a season of change, and it will feel like a temperature roller coaster ride for millions of people this year,” AccuWeather lead long-range expert stated in a release “Winter will overstay its welcome in parts of the Northeast." Here's more about the report on the extended forecast. AccuWeather meteorologists stated in the extended forecast that "the first weeks of spring may feel more like winter across the northern half of the country this year." Pastelok explained that people near rivers prone to ice jams should be "vigilant for potential issues this spring." Lingering cold air will also be a concern for farmers and gardeners in parts of the Northeast, AccuWeather stated in the report "The last frost of the season may arrive days to weeks later than the historical average in some areas of the Northeast," the report added There could be some late-season snow in the interior northeast as well The extended forecast stated, "The potential for late-season snow combined with persistent chilly air could benefit ski resorts across the east by providing more opportunities to make artificial snow to extend the season." What's the forecasted 'trend' for spring?AccuWeather Senior Meteorologist and Climate Expert Brett Anderson stated in the extended forecast that "the overall trend for the spring season in the U.S is getting warmer," despite the prediction for colder temperatures hanging on for a while in the northeast Overall, the temperatures have increased by "roughly 2 degrees Fahrenheit across the contiguous U.S. since 1970," according to AccuWeather. AccuWeather noted that warmer spring seasons in the U.S and a longer growing season for farmers and gardeners not to mention "problems with pests like ticks and mosquitoes becoming active and reproducing earlier in the season." Meteorological spring starts on March 1, while astronomical spring begins during the March equinox at 5:01 a.m Meteorological spring in the Northern Hemisphere includes March In a past interview with Wicked Local, Alan Dunham, a meteorologist with the National Weather Service in Norton explained that keeping meteorological and astronomical spring seasons separate "helps us keep better records."   He was born and raised in Cold Spring and graduated from Haldane High School in 1980 He worked at Orentreich Foundation for the Advancement of Science (“O Farms”) as a Master Carpenter and the Property Caretaker for 34 years He was an avid outdoorsman and spent much of his time hunting He was an active member of the Cold Spring Boat club.  with a smile on his face that would immediately put you at ease He could find common interests with anyone he would talk to and was quick to make friends with those he came to meet he was loved and surrounded by many throughout his life.  He was a fixture out on the water with his wife LeeAnn and would often be seen with family and friends enjoying the weather and fishing on the Hudson River Jimmy loved to vacation with family and friends down at the Jersey Shore and Florida A Funeral Service will be offered at 3:30pm on Saturday.  How do you turn a small but influential science education outpost into one of the world’s leading destinations for breakthrough bioscience This year marks the centennial anniversary of the formation of the Cold Spring Harbor Laboratory Association (CSHLA) Formerly known as the Long Island Biological Association (LIBA) the CSHLA is a remarkable group with a remarkable history the Brooklyn Institute of Arts and Sciences (BIAS) established the Biological Laboratory at Cold Spring Harbor as a summer school for training biology teachers and students Early courses covered topics such as zoology Initially housed in the New York State Fish Hatchery the Laboratory moved across the road to land provided by the Jones family which later set up a nonprofit corporation called the Wawepex Society to hold a title for the property New Yorkers will recognize the name ‘Jones’ for its connection to Jones Beach The phrase “keeping up with the Joneses” also refers to this family the Laboratory’s relationship with BIAS became increasingly fraught Things came to a head in 1914 when the director of the Laboratory threatened to resign the Laboratory was made a department of BIAS efforts were renewed to create an endowment for the Laboratory Through the generosity of a small number of local supporters—including Louis Comfort Tiffany and Cornelia Prime—the remarkable sum of $27,000 was raised in just eight months $27,000 in 1917 equals about $700,000 in 2024 a local organization of neighbors voted to form the Association the first meeting of the Board of Directors was held the Brooklyn Institute formally turned over its buildings along with its endowment and scholarship funds The Wawepex Society transferred ownership of Jones Laboratory and drafted a 50-year lease for the grounds The 1924 Biological Laboratory Annual Report (pdf) listed LIBA’s first members There were six “Founding Members” and 19 “Patrons” who each contributed $5,000 and $500 There were also more than 170 “Sustaining Members” whose combined contributions totaled $1,700 The membership list includes such illustrious names as J.P LIBA’s importance to the Biological Laboratory became immediately apparent LIBA members raised the funds needed to purchase 32.5 acres of land adjacent to the Laboratory Acosta Nichols donated $12,000 for the construction of a lab in memory of their son George who had taken part in a nature studies class held on campus LIBA also became known across the region for its impressive “Gold Coast” galas. One example took place in 1932. It was during this year that the Field family held a grand fundraising event at Caumsett Attended by celebrities such as Fred Astaire the gala included activities like dancing and china breaking (“China breaking” is exactly what it sounds like The activity was overseen by prominent businessman Vincent Astor.) All told LIBA members contributed between 7% and 10% of the Biological Laboratory’s income LIBA’s modern era began in 1962 when the institute we now know as Cold Spring Harbor Laboratory first took the name of its neighboring community. It was during this year that the Carnegie Institution closed the Department of Genetics. Its land and buildings were combined with those of the Biological Laboratory to create the Cold Spring Harbor Laboratory of Quantitative Biology (The name would be shortened to Cold Spring Harbor Laboratory in 1970.) LIBA did not have any direct responsibility for governing the new institute the Association did retain two places on the new Board of Trustees It now fully devoted itself to ambassadorship and fundraising And it accomplished these goals with great success For example, in 1972, LIBA Chairman Edward Pulling led a campaign that raised $250,000 for a new addition to Jones Laboratory he helped raise $225,000 to build a new Williams House and another $200,000 to purchase land still owned by the Carnegie Institution In one historic gift, LIBA contributed $600,000 toward the cost of the Oliver and Lorraine Grace Auditorium. Grace is the primary venue for CSHL’s world-renowned Meetings & Courses Program This program has brought hundreds of thousands of leading scientists to Cold Spring Harbor and planted the seeds of countless breakthroughs there’s really no way to quantify the return on this investment LIBA officially became the Cold Spring Harbor Laboratory Association (CSHLA) The Association has since furthered its mission to provide CSHL with much-needed philanthropic support CSHLA members have helped raise an extraordinary $80 million in unrestricted funding for the Laboratory many of the labs and other facilities found across campus today owe their existence to CSHLA members Of course, a lot has changed since the early days. After all, today’s Association gatherings are unlikely to break out in spontaneous bouts of china breaking. Nevertheless, CSHLA continues to bring some of Long Island’s best and brightest together for a worthy cause. Current Association Directors include acclaimed actress Susan Lucci and the late best-selling novelist Nelson DeMille among many other prominent community members LIBA and CSHLA have played an essential role in supporting the advancement of science at Cold Spring Harbor Its members and their community have transformed a small summer school into one of the world’s most renowned institutes for cutting-edge science research and education to say the least—one that holds great promise and potential for the next 100 years