The Department of Defense is suspending helicopter training flights in the Washington, D.C., region, specifically near the Pentagon. This change comes just days after the Army resumed training flights in the area following January’s deadly midair collision between a Black Hawk and American Eagle CRJ-700 On Thursday, two separate commercial flights—operated by Republic Airways and Delta Air Lines—were forced to go-around while on approach to Runway 19 at Ronald Reagan Washington National Airport (KDCA) An air traffic controller instructed the two aircraft to go around in order to avoid a Black Hawk helicopter The Black Hawk was operating under the Priority Air Transport (PAT) call sign the same one involved in January’s accident According to CBS News the Army had a four-week plan to restart helicopter training in the region after the collision Now, flights will be halted again into the Pentagon, Politico reported An Army spokesperson told the outlet that this pause is pending an internal inquiry The suspension applies to operations in the Army’s 12th Aviation Battalion the same unit involved in January’s accident This pause only pertains to flights into the Pentagon which is located less than 2 miles from Reagan National The National Transportation Safety Board (NTSB) is probing Thursday’s incident. The FAA stated that the Black Hawk crew did not follow published procedures, instead opting for a “scenic route.”  Watch SNYLog In Mets' foundation for pitching success a process five years in the making -- with many to thank Jets Draft Report Card: Grading Gang Green's picks Dart is Giants' future, it's only a matter of time before he's their present Grading the Jets pick of Membou in the draft Grading the Giants pick of Carter Mets' wave of rapidly approaching pitching prospects is tantalizing — and potential X-factor Mets Minor League Mailbag: Could a top pitching prospect come up as a reliever? Giants Draft Report Card: Grading Big Blue's picks Jets establishing their identity under Glenn with Membou selection Everything you need to know about Giants first-round pick Carter With Sproat close, Mets could soon have a good conundrum on their hands Mets top 30 prospects for 2025 season Ewing arrives in Tucson after two seasons on Burke's staff at the University at Buffalo where he played a key role in back-to-back postseason runs Ewing helped lead the Bulls to a program-record 30 wins and a WNIT Championship Buffalo also posted a seven-win improvement in league play — the highest in the MAC — as Ewing helped mentor standout post player Alexis Davis Bonaventure (2022-23) and Daemen College (2021-22) where he was instrumental in developing post players and managing recruiting he helped guide conference Player of the Year and First Team All-American Katie Titus while also coordinating the program's recruiting efforts Ewing began his collegiate coaching career at Bryant & Stratton College in 2020-21 helping lead the Bobcats to a USCAA conference runner-up finish Ewing played two seasons at the University of Toledo (2011–13) where he was part of a MAC West Division Championship squad before completing his career at Mercyhurst (2013–15) he led the Lakers in rebounding and helped the program reach its first NCAA Tournament appearance He graduated from Mercyhurst in 2015 with a degree in business and hospitality Ewing also played professionally for the Buffalo 716ers of the Premier Basketball League (PBL) He went on to spend three seasons playing in the National Elite Basketball League (NEBL) in Belize earning three All-Star selections and averaging more than 16 points per game Ewing was a standout at Cardinal O'Hara High School where he scored over 1,400 career points and was a First Team All-State selection He also played a postgraduate season at IMG Academy Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here Texas sophomore Brayden Taivassalo has announced that he is transferring to Arizona State University for the next season Backstroker and redshirt sophomore JT Ewing has confirmed he will transfer from NC State to Arizona State for the 2025–2026 collegiate season Andrew Taylor is the second Gator to announce their move to Tempe for next season as he follows Adam Chaney to the desert Mehraban looks to boost the sprint free group at Texas as the team had no individual finalists in the 50 or 100 freestyles at 2025 NCAAs Chaney instantly boosts the team’s medley relay as he would have been the top 100 backstroker by over a second this past season May 01st, 2025 Big 12, College, News, Transfers Fitter and Faster Swim Camps is the proud sponsor of SwimSwam’s College Recruiting Channel and all commitment news swimming in college is a lifelong dream that is pursued with dedication and determination Fitter and Faster is proud to honor these athletes and those who supported them on their journey ACC finalist and NCAA qualifier JT Ewing confirmed to SwimSwam that he will transfer to Arizona State University for the 2025-2026 season. Ewing, a redshirt sophomore at North Carolina State University, has two years of eligibility remaining. A post shared by JT Ewing (@jtewing.88) spent the past three seasons with NC State specializing in the backstroke events with a secondary focus on middle-distance freestyle the former Wolfpack swimmer raced the 200 back three times at the Bulldog Last Chance Meet to clinch his NCAA berth Ewing recorded a time of 46.35 in the 100 back prelims setting a personal best and finishing 24th His 100 back best of 46.32 comes from the 2023 NC State Invitational He did not swim at the 2025 ACC Championships Ewing qualified for the 2024 NCAAs after swimming the 200 back three times at the 2024 Bulldog Last Chance Meet but was left off NC State’s final roster where he made the ‘A’ final of the 200 back with a 1:40.78 in prelims before touching 8th in the final with a time of 1:42.82 He raced the 200 back at both meets and added the 100 back in 2024 when he placed 17th in the 200 back with a time of 1:59.47—just one spot shy of advancing to the semifinals His personal best in the event is 1:57.71 (long course meters) Chaney was originally slated to return to Florida but did not compete for the Gators this season and entered the transfer portal in January as a graduate transfer Additionally, the Sun Devils have added SEC champion Andrew Taylor, NCAA ‘B’ finalist Jordan Tiffany and NCAA All-American Remi Fabiani via the transfer portal for next season ASU just wrapped up their first season as a member of the Big 12 Conference and has established itself as the new superpower, winning by over 600 points ahead of 2nd-place University of Arizona. This came after Texas left for the Southeastern Conference following last season. The Sun Devils, now under first-year head coach Herbie Behm finished 6th at the 2025 NCAA Championships after winning the overall title in the 2023–24 season If you have a commitment to report, please send an email with a photo (landscape, or horizontal, looks best) and a quote to [email protected] Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" Δdocument.getElementById( "ak_js_2" ).setAttribute( "value" They had a relatively-small roster last season (27) after the post-Bowman transfer exodus though they only had 31 in 2023-2024 so they never carried a huge roster that schools like Auburn did Every time I see a commit pic in front of that pool I get very jealous because that is not what my home pool looks like at all I hope he takes another step forward in his swimming career Quietly putting together a hell of a roster over there 👀👀 I expect he’ll contribute more at ASU where being NCAA-scoring in one event is more important than Big XII-scoring in three events More from Sean GriffinSee All Subscribe to our newsletter and receive our latest updates “Golf With Jay Delsing” features all aspects of Norwood Hills CC The guests will include GM/COO of Norwood Hills Dane McLaird and their Director of Instruction the show will talk it over with Alonzo Byrd from the Stifel Charity Classic See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info Need help accessing the FCC Public File due to a disability Please contact Melissa Johnson at publicfilestlouis@hubbardradio.com This web site is not intended for users located within the European Economic Area This 'freak athlete' Mets prospect is creating a buzzApril 18th NEW YORK -- Earlier this week, Mets director of player development Andrew Christie was chatting with JT Schwartz, a longtime Mets farmhand who was rehabbing at the team’s Spring Training complex in Port St. Lucie, Fla. While in Florida, Schwartz had a firsthand look at A.J. Ewing the buzziest Mets prospect of the early Minor League season “And he really is,” Christie later said in a telephone interview Selected with the 2023 compensatory pick the Mets received for losing Jacob deGrom in free agency, at 134th overall, Ewing entered the year as Pipeline’s No. 28 Mets prospect finishing a homer shy of the cycle to raise his batting average to .459 -- tops of anyone at that level he ranked Top 5 in batting average in the entire Minor Leagues “It just took him a little bit to get acclimated to pro ball,” Christie said He’s got a really good idea of the strike zone One scout who’s seen Ewing play this spring defined him as a likely bench player But Ewing has been hitting the ball in the air with regularity and recently bashed a 109 mph home run -- indications that he can grow as a hitter Although Ewing has far more swing-and-miss to his game than Morabito he’s walked more than he’s struck out so far this season when Christie told him he’d be returning to Single-A St Lucie (the Mets’ lowest full-season affiliate) to start the year Ewing responded: “I’m going to make your life very difficult to keep me there.” Said Christie: “He is delivering thus far.” Triple-A SyracuseNo. 11 prospect Drew Gilbert -- one of the pieces the Mets received from the Astros for Justin Verlander in 2023 -- finally made it back to Syracuse this week after a delayed start to his season The Mets have progressed slowly with Gilbert who strained his hamstring early last April and didn’t return until late July Team officials felt that an elongated ramp-up could only help Gilbert who’s been working not just on healing his hamstrings but on strengthening them to avoid future problems Gilbert set a new personal best sprint speed on the field Double-A BinghamtonRyan Clifford, the other player the Mets received for Verlander, is heating up at the plate. After going hitless in his first three games, Clifford had two multi-hit efforts in his next six. Three of his half-dozen hits over that stretch went for extra bases, and Clifford walked as often has he struck out during those games. The Mets’ No. 4 prospect Clifford spent his final 98 games of last season at Binghamton That makes him ripe for an early-summer promotion High-A BrooklynThe hottest hitter at Brooklyn, without question, is No. 22 prospect Chris Suero The catcher hit five home runs in his first nine games with a .353/.405/.941 slash line over that stretch which is why the Mets have given him reps at first base and left field in addition to behind the plate He could even eventually see time in center meaning his hot start may soon result in a bump up the ladder .. but he’ll probably need to cut down on his hefty strikeout rate before that happens Sign up to receive our daily Morning Lineup to stay in the know about the latest trending topics around Major League Baseball Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application Arrangements are by Boxwell Brothers Funeral Directors He graduated from Dimmitt High School in 1958 where he served with the 101st Airborne Division from 1963 to 1965 After his honorable service to his country earned an associate’s degree from Amarillo College worked for Diamond Shamrock before joining the Potter County Auditor’s office He retired as Potter County Auditor in 2005 and together they shared a life full of love cherishing the time spent with his children and grandchildren Paul Methodist Church and served as a board member of the National Women’s Invitational Tournament (NWIT) Charlie and Alice Purcell; and his brothers-in-law of Amarillo; daughters Jaime Samford and her husband Damon of Bushland and Janna Miller and her husband Ben of McKinney; grandchildren Ryan Samford and Katelyn Miller; his brother Edward Ewing and his wife Sharon of Dimmitt; sisters Irene Miller all of Dimmitt; sister-in-laws Nancy Lindegren of Amarillo and Carol Sue Purcell of Plainview; and numerous nieces and nephews He will be deeply missed by all who knew him Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors NORFOLK, Va. — Sentara Norfolk General Hospital on Saturday hosted a community health event aimed at promoting education and access to care for residents of Hampton Roads. Attendees found more than 50 tables filled with resources and services tailored to meet various healthcare needs. Sentara Associate Chief Nursing Officer Misa Ewing emphasized the importance of such events. “Today’s objective is to provide education, offer access to care, and create collaboration opportunities among our community partners," she told Norfolk Neighborhood reporter Jay Greene. This event is essential for raising community awareness and connecting people to services beyond today.” Among the array of offerings were dental services, screenings for breast cancer and colorectal issues, trauma prevention strategies, CPR training, and heart health promotion. People also received practical items, like toothbrushes and bracelets, along with American Heart Association's portable mannequins to practice CPR at home. “Even in rural areas, where it might take time for EMS to arrive, this training can exponentially increase the chances of saving a life,” Ewing said. The event not only focused on health but also included a talent acquisition department providing job opportunities. "We holistically provide services beyond health and education," Ewing noted. "We also have job offerings today, allowing us to serve the community in multiple dimensions." Ewing shared anecdotes about attendees discovering health issues they weren’t aware of prior, which empowered them to seek necessary care. “Through our ACC clinic, we connect individuals with the full gamut of care services they may need,” she said. While the event was filled with valuable health services, the ambiance was enjoyable and engaging, featuring music, food trucks, a petting zoo, and bubbles to ensure families felt welcome. For those who couldn't attend, Ewing recommended visiting Sentara's website for more information and resources. Copyright © 2022 ALM Media Properties, LLC. Daniel E. Cummins of the Clarks Summit law firm of Cummins Law recently presented the "Tort Talk Top 10" CLE at the Personal Injury Potpourri CLE presented by the Dispute Resolution Institute in Philadelphia. Cummins of the Clarks Summit law firm of Cummins Law recently presented the "Tort Talk Top 10" CLE at the Personal Injury Potpourri CLE presented by the Dispute Resolution Institute in Philadelphia The presentation covered and analyzed the top 10 cases and trends in civil litigation matters over the past year Daily Business Review Connecticut Law Tribune Law.com Corporate Counsel Brugh Lower of Gibbons has entered an appearance for industrial equipment supplier Devco Corporation in a pending trademark infringement lawsuit accusing the defendant of selling knock-off Graco products 18 in New Jersey District Court by Rivkin Radler on behalf of Graco Inc Read More Yalowitz of Arnold & Porter Kaye Scholer have entered their appearances for Hanaco Venture Capital and its executives 24 in New York Southern District Court by Zell accuses the defendants of negligently and fraudulently managing the plaintiff's $1 million investment Read More Attorneys from A&O Shearman has stepped in as defense counsel for Toronto-Dominion Bank and other defendants in a pending securities class action 11 in New York Southern District Court by Bleichmar Fonti & Auld accuses the defendants of concealing the bank's 'pervasive' deficiencies in regards to its compliance with the Bank Secrecy Act and the quality of its anti-money laundering controls Read More a Pennsylvania company providing shared communications infrastructure Wolf of Gordon Rees Scully Mansukhani to fend off a pending breach-of-contract lawsuit 25 in Michigan Eastern District Court by Hooper Hathaway PC on behalf of The Town Residences LLC accuses Crown Castle of failing to transfer approximately $30,000 in utility payments from T-Mobile in breach of a roof-top lease and assignment agreement Read More Schwartz of McCarter & English have stepped in as defense counsel to Electrolux Home Products Inc 26 in New York Eastern District Court by Poulos Lopiccolo PC and Nagel Rice LLP on behalf of David Stern alleges that the defendant's refrigerators’ drawers and shelving repeatedly break and fall apart within months after purchase Read More Already have an account? Sign In An announcement to “build out a brand-new air traffic control infrastructure system” is coming soon Transportation Secretary Sean Duffy said during a press briefing on Thursday President Donald Trump and Duffy have been roadshowing a plan to completely overhaul the United States’ aging air traffic control system which Trump called “very obsolete.” He continued to say that January’s deadly midair collision at Reagan Washington National Airport (KDCA) near Washington “wouldn’t have happened if we had the right equipment.” Duffy added that an announcement on this overhaul will be coming in a matter of days we’re going to talk about the infrastructure on the airspace,” he said On Thursday, the FAA and the National Air Traffic Controllers Association (NATCA) detailed a plan to give cash bonuses to air traffic controllers (ATCs) for agreeing to work in hard-to-staff or high-cost-of-living regions concerted effort to go ‘how do you make up the gap?’” Duffy said “And we can’t snap our fingers to make up the numbers Trump tossed around potential private contractors to overhaul the ATC network But it would be ideal to have a single contractor “We’re going to have a broader press conference next week on what that plan looks like,” Duffy said Thursday 30 years behind the curve on building a brand-new system.” Duffy shared that he’s already laid out this plan to Trump: “I’ve had a conversation with the president I’ve laid out our ideas for a brand-new air traffic control system.” “I’ve heard him for years talk about the problems within the American [ATC] system and how he wants to fix it and Jame Ewing begins his first season as an assistant coach on the Arizona Women’s Basketball staff after being named to Head Coach Becky Burke’s inaugural staff on April 16 Ewing has worked alongside Burke since 2023 playing a key role in building success at the University at Buffalo Ewing helped guide Buffalo to a program-record 30 wins and a WNIT Championship In his first season with the Bulls (2023-24) the Bulls’ post players thrived — including standout Alexis Davis who led the team in rebounding and anchored UB’s frontcourt Ewing joined Buffalo following a season at St where he served as assistant coach and director of basketball operations he held an assistant coaching role at Daemen College in 2021-22 where he worked with the post players and helped develop Katie Titus into a conference Player of the Year and First Team All-American He also led the program’s recruiting efforts he was an assistant coach at Bryant & Stratton College helping the Bobcats to a runner-up finish in the USCAA Ewing played two seasons at Toledo (2011–13) helping the Rockets to a MAC West Division title before finishing his career at Mercyhurst (2013–15) he was the team’s leading rebounder and a key part of Mercyhurst’s first-ever NCAA Tournament appearance He earned his bachelor’s degree in business and hospitality from Mercyhurst in 2015 Ewing played professionally with the Buffalo 716ers in the Premier Basketball League He then spent three seasons in Belize’s National Elite Basketball League earning three All-Star selections and averaging over 16 points per game during his time with the Dangriga Warriors and Orange Walk Running Rebels Ewing was a standout at Cardinal O’Hara High School where he was a three-time First Team All-Catholic selection and a First Team All-State honoree He scored more than 1,400 points during his prep career and went on to play a postgraduate year at IMG Academy Thanks for visiting James "Jim" Edison Ewing 64 years old from Fort Worth Texas passed away on April 18 1960 to James and Frances Ewing in Jeffersonville  He was a proud Choctaw Native American He dropped out of high school to work full time and was a self-made man He later went on to study and got his GED diploma Jim later on went to start his own metal fabrication business known as ARC Enterprises  Some of the best highlights of his career were putting up the gateway monuments in Arlington's highways.   and they celebrated a loving marriage that lasted 47 years Brandy Ewing Bunch and John Ewing both of Fort Worth Texas and they also have three dearly loved grandchildren Jim spent his spare time working because that was his enjoyment and helping others with any projects they had He worked extremely hard to support his family Jim was predeceased by his father James and mother Frances We have the address for the funeral home & the family on file If you're not happy with your card we'll send a replacement or refund your money James Tyler Ewing, of Easton, Maryland departed his tired earthly body on November 8, 2024. He left this world to join his Lord and Savior in heaven. Born on April 21st, 1991 in Easton, he was the son of David Allen Ewing Sr. and Tamela (Hare)... View Obituary & Service Information The family of James Tyler Ewing created this Life Tributes page to make it easy to share your memories Made with love by funeralOne he immigrated to the United States with his parents and younger brother and took great pride in preparing home-cooked meals to share with his loved ones He was a loyal Philadelphia Eagles fan and had a deep love for bluegrass music and the band Phish Victor spent many formative summers at Camp Shomria in Liberty a place that held deep significance for him where he made lifelong friends and met his wife loving home together with their two daughters Victor was a dedicated and valued employee of SES Americom Inc He had a generous spirit and a great sense of humor Relationships were at the center of his life and made him happy Funeral Services will take place at 10:00 a.m Shiva will be observed immediately following the funeral and again on Monday A final day of Shiva will be held on Tuesday In lieu of flowers, contributions to the college funds of Mia and Sophie Kogan are much appreciated. Gifts can be made at Ugift529.com Funeral arrangements are by Orland’s Ewing Memorial Chapel. OrlandsMemorialChapel.com/Victor-Kogan Victor hired me for one of my very first professional jobs. You could quickly tell he is an excellent mentor and friend who really looks out for you. Just an incredible guy who leaves everything he touches in better shape. Victor will live through those who know him with the good examples he taught us, and his fun personality will be sorely missed. Your email address will not be published. Required fields are marked * Δdocument.getElementById( "ak_js_1" ).setAttribute( "value", ( new Date() ).getTime() ); removing any reference to Europe from the commemoration US political commentator Jennifer Ewing has highlighted a peculiar detail about Donald Trump's decision to rename VE Day as Victory Day for World War II The former president announced the change on his Truth Social platform Ewing pointed out to GB News that Americans don't actually celebrate VE Day in the first place making the entire announcement rather perplexing Trump declared on Truth Social: "I am hereby renaming May 8th as Victory Day for World War II and November 11th as Victory Day for World War I." The former president claimed America had done "more than any other country" in achieving victory in World War II Ewing told GB News: "I can completely see how it’s disrespectful to other countries what’s confusing me and confusing a lot of Americans is that we don’t celebrate VE Day in America this announcement didn’t come with an executive order Congress would need to approve any name change for a holiday I go back to the point that we don’t celebrate this day in America I would say that if we did celebrate this day and he was going to change it I could see how it would be disrespectful to others who participated with us and led us in that war for sure." nobody was close to us in terms of strength but we never celebrate anything," Trump wrote He attributed this lack of celebration to the fact that "we don't have leaders anymore Trump concluded his announcement by declaring: "We are going to start celebrating our victories again!" Trump's claims about America's role in the wars have sparked controversy particularly his assertion that "nobody was close to us" in terms of contribution Critics have pointed out that his statement might offend allies like Britain and Russia The Russian Victory Day on 9 May commemorates the 27 million Soviet citizens who died during the conflict approximately 418,500 Americans were killed in both European and Pacific theatres "It was crazy and it was all going so fast," Tilton recals of her time on the popular nighttime soap playAncelotti: Mbappé can be a Real Madrid legend like Ronaldo (1:32)Carlo Ancelotti explains why Kylian Mbappé can become a Real Madrid legend and achieve the same as Cristiano Ronaldo Back in a 1999 column, my old boss, Bill Simmons, coined the Ewing Theory. A friend of his "was convinced that Patrick Ewing's teams (both at Georgetown and with New York) inexplicably played better when Ewing was either injured or missing extended stretches because of foul trouble," he later wrote for ESPN Ewing was a star center for the New York Knicks his career directly coincided with a guy named Michael Jordan so Ewing's Knicks won lots and lots of games Ewing had just gone down with an Achilles injury during the 1999 Eastern Conference finals Everyone assumed the Packers would walk to the NBA finals and the Knicks immediately won three straight games to clinch the series not been back to the Eastern Conference finals in the two decades since Ewing left the team Simmons only landed on Ewing for the theory because a buddy of his was obsessed with that particular example, but the idea was more important than the individual. As he wrote in a 2013 update: That's the thing about the Ewing Theory .. or mistakenly believed he was more valuable than he was an injury or departure can lead to more minutes for players who fit that team's style and framework better it might take a simple injury for everyone to realize everything falls into place and you're a team Let's dig into why Mbappé made Real Madrid worse and what it all says about Mbappé as a player Madrid's defense was already getting by on individual brilliance -- great goalkeeping the athletic range of their young midfielders and elite center-back play who is genuinely one of the worst and least active out-of-possession forwards in the world was going to put even more stress on a defense that wasn't protected by a sound underlying structure These are their adjusted goals allowed (a blend of 70% expected goals and 30% goals) over the past two seasons it's not even clear that Mbappé's arrival has made the defense worse at all we'd expect Madrid's defensive performance to decline a little bit That should've been a massive win for Madrid I can't stress this enough: The defending Champions League winners added arguably the best attacker in the world .. Here are those same adjusted goal numbers for the other end of the field: These players all have multiple elite-level skills so we might see Raphinha drive the ball forward and slip a through ball to Yamal who plays a cut back for Lewandowski to score the goal Lewandowski will dart across to the near post to take more defenders with him and Raphinha will crash the far post to finish off a curled ball in from Yamal you might have attacks where the players have more static skills -- each one is really good at one particular thing -- but it usually works because each of those skills complement each other Their two best attackers pretty much do the exact same thing: peel off to the left wing and try to run into the penalty area Just take a look at Mbappé's heat map of touches for the season: Perhaps this could work if there was a third attacker who was constantly crashing into the center of the box or maybe a ball-dominant creative type on the right who was springing Mbappé and Vinícius into these spaces on the left side But among wingers in Europe's Big Five top leagues over the past 365 days Rodrygo ranks in the 13th percentile for expected goals assisted The common thread among Madrid's three attackers is that none of them are getting on the ball in the middle of the field And here's a little industry secret about the middle of the field: it's where the goal is On top of all this, Madrid also lost midfielder Toni Kroos to retirement over the offseason so the team never really had any kind of reliable systematic way of getting the ball up to these forwards Perhaps a more consistent pattern of ball progression would have brought the ball up to the forwards in a way where even their lopsided movements would've been able to rip apart unsettled or under-manned defenses Instead, more often than not, it's looked like what we saw against Arsenal: Needing to win by at least three goals at home this collection of uber-expensive and super-talented attackers only created one decent chance off of a defensive error and otherwise were left shooting from tight angles and long distances -- far away from the center of the goal I still think we're better in attack and defense without Mbappé." That's PSG manager Luis Enrique right after his club knocked Liverpool out of the Champions League By those same numbers we looked at for Madrid, here's how PSG have progressed defensively in Ligue 1: and allowing significantly fewer touches inside their own penalty area they're attempting almost four extra shots per game and getting into the opposition penalty area more often The only thing that's gotten "worse" is the quality of shots they're allowing: 0.09 xG per shot last season is a good thing because it's indicative of a team that's able to press much more aggressively and much higher than last year the best is that you'll allow better chances but also fewer chances and it'll all add up to a decline in goals conceded.) there's just no way PSG would've been able to press Liverpool off the field like they did this season The attack also benefits from a press that keeps the ball in the attacking third for most of every match and from the opportunities created by winning the ball back right as the opposition is transitioning from a defensive to an attacking structure Without Mbappé, who doesn't touch the ball a ton, is most effective in space, and likes to peel off left, the attack is also much more fluid and unpredictable. With the arrival of Khvicha Kvaratskhelia from Napoli in January PSG now have four attackers who are devastating with the ball at their feet but also comfortable running into space and slipping passes through the opposition backline The effectiveness of the press, too, allows both of their fullbacks, Nuno Mendes and Achraf Hakimi to get forward aggressively and contribute to the attack While the various pieces of Madrid's lineup almost seem to actively negate each other PSG's players all seem to amplify each other's strengths While I tend to believe that talent always trumps tactics -- and while almost every great manager is on the record in agreement with me -- that's the remaining elephant in the room When Bill Simmons outlined the Ewing Theory he made it clear he wasn't saying that Patrick Ewing was necessarily worse than everyone thought he was saying that specific circumstances sometimes create a situation where a team plays better without its best player and the coaching circumstances at PSG and Real Madrid couldn't be any different Luis Enrique is one of the most tactically demanding managers in the world -- he has a clear way that he wants his teams to play And he's done a brilliant job at PSG so far this season It's not a given that a bunch of ball-dominant dribble-happy wingers should work so well in an attack, but Luis Enrique has figured it out, largely by freeing up Ousmane Dembélé to play centrally and do what he does best: everything, with either foot Meanwhile, Carlo Ancelotti said this at the beginning of last season: "I think the mistake new generation coaches make is that they give too much information about the system on the ball I think old school coaches like me prefer not to give too much information and allow freedom for creativity." That approach has worked brilliantly at Madrid a club that's able to attract the best creative players in the world Vinicius and Mbappé's instincts always take them to the same area of the field Mbappé is still having a fantastic individual season which values everything a player does on the ball has Mbappé adding 10.57 goals compared to the average player at his position That's the highest number of any player in Europe's Big Five leagues and Liverpool's Salah (10.12) is the only other player with a number north of nine But Madrid are simply a significantly worse team since he arrived And the difference between Mbappé and everyone else on Madrid is that everyone else had already been a significant contributor to this team when it was the best team in the world We've seen them do it -- we still haven't seen him do it Mbappé is just a really hard player to fit into an elite team he limits the approaches you can take without the ball he's not the kind of high-touch player you can just ping the ball out to over and over again while he creates a ton of chances for himself and his teammates You need a very specific blend of players both offensively and defensively to get the most out of Mbappé until further notice -- until we see Mbappé actually be the best player on the best team in the world -- we're officially designating Mbappé as soccer's face of the Ewing Theory what would be the greatest triumph for the Ewing Theory?" At the time he suggested the 2001 Seattle Mariners winning their first-ever World Series after eventual Hall-of-Famers Randy Johnson The Mariners won an MLB-record 116 games in 2001 but lost in the American League Championship Series to the New York Yankees Well, PSG lost Neymar and Lionel Messi two seasons ago and they're just three games away from winning their first-ever Champions League Ewing argues that schools have been used to harm Black and Native people Ewing is a self-proclaimed “school person,” a declaration she makes often in discussing her new book Original Sins: The (Mis)education of Black and Native Children and the Construction of American Racism and University of Chicago professor contends that the American education system has been deeply shaped by systemic prejudice and has historically favored white students and belittled their Black and Indigenous peers she challenges readers to confront this uncomfortable truth so they can reimagine what schools could be You have described this book as subject matter you’d felt was missing from the curriculum Why was it so important for you to write it I became very aware of race at a young age You don’t have to try very hard as a kid to notice how things feel unfair or illogical — and how often those feelings fall along racial lines I learned more about the history of schooling in the United States and read documents about the education of Indigenous and formerly enslaved people What shocked me was the explicitness of it — to see people say very expressly in print things like “If we want to make war against Native people it’s actually less expensive to take their kids and wage war in the classroom.” But then you also have W.E.B Du Bois basically saying that Black people invented the idea of universal public education in the South during Reconstruction So you have these two things in tandem: schools being integral to the freedom dream of a people and schools used very intentionally as a source of harm and social control I’d cobble together readings for my students to explore these ideas Where’s the book that ties this all together “Schools are not bystanders in the project of racial capitalism and genocide in the United States; they have been laboratories where those ideas were honed You’ve written and spoken a lot about how schools are important places of nurturing and community building you make a strong case that the broader education system has done irrecoverable damage One example is how in the mid-19th century Boston ruled to uphold segregated public schools due to the “mental and moral” differences between races which is page after page of damning evidence about the harm schools have caused I still consider myself a “school person.” I believe in the promise of schools because there are also stories of incredible creativity Schools can be sites of celebration and community strength building How do we reimagine what these spaces could be The book argues that there is a kind of smog in the historical record that has obscured the mistreatment of Black and Native people in schools who celebrated Black education but also wrote that Black children “could not compare” with white ones Why is it important to correct that record now Schools are not bystanders in the project of racial capitalism and genocide in the United States; they have been laboratories where those ideas were honed Correcting the record isn’t just about understanding the past It’s important to have those facts to understand what it is that we’re actually fighting this book is about providing a firm evidentiary basis for those who are committed to justice and want to think more critically about how schools perpetuate harm and what social transformation might look like we’ve seen an intense political battle emerge over how American history is taught Original Sins dives into some uncomfortable territory like how government leaders sought to “civilize” Native children and saw schools as a means to assimilate them How are you preparing for the inevitable backlash I think about what Toni Morrison taught us: The function of that kind of reaction is distraction Every moment I spend fighting those battles is a moment I’m not writing I love real critique and discussion from people who read the book and have a shared desire to love and celebrate children That’s a discussion I welcome and I’m excited about Everything else I can’t really be bothered with you note that the book is not intended to be a how-to guide for fixing schools you hope that it starts a broader conversation what does a “good school” look like to you One issue is that we’ve become good at fiddling around the edges without tackling the root questions: What is a school a good school is a place that serves as a home for imagination and philosophical — in a way that nourishes not only students but the broader community It could be schooling that is integrated with the natural environment or one where there are people of all different ages It could be a place where the line between who’s a teacher and who’s a learner is a lot blurrier It would look different for different communities I want people to develop a sense of curiosity about the spaces they’re building together and to make those points of connection for themselves — and to question the habits we have picked up as an institution that we don’t even think about How do we see connections between those practices and histories Where can we be more imaginative in doing things differently This isn’t about a step-by-step toolkit; it’s about asking deep open-ended questions and fostering collective work toward justice and joy What excites me is knowing that educators and community members are always doing that kind of reinvention work Du Bois famously posed this haunting question in 1903 in his classic work The Souls of Black Folk especially whenever I encounter one particular line from Thomas Jefferson’s Notes on the State of Virginia: “Among the blacks is misery enough sending me spinning through my own vignettes of the Black poets who set a course for my thriving my class took a three-day trip to Washington Parts of Jefferson’s legacy were omnipresent in my experience of schooling Tags: , Chicago magazine newsletters have you covered She is the daughter of Virgil Boughton and Mitzie Flasher Anthony Melanie was a lifelong Warren area resident She was a 1982 graduate of Warren Area High School with Warren General Hospital in the Environmental Services Deptartment Melanie was a member of First Lutheran Church She loved and was very passionate about being a grandmother she is survived by her husband of 41 years Raegan and Easton Moore; her brother-in-law She was preceded in death by her stillborn son A private celebration of Melanie’s life will be held at the convenience of the family Those wishing to place memorials may do so through First Lutheran Church E-mail condolences may be sent by visiting www.lewisfuneralhomeinc.com The Donald E has been entrusted with funeral arrangements Copyright © 2025 Ogden Newspapers of Pennsylvania LLC | https://www.timesobserver.com | PO Box 188 With profound sadness we announce the passing of Sean Alan Ewing (33) on November 12th to John Ewing and Susan (Padesky) Heuslein He grew up in a home filled with love and devotion and graduated from Holmen High School where he formed lasting connections.  Sean’s faith in Jesus was the cornerstone of his life shaping his values and the way he cared for others always willing to lend a helping hand and uplift those around him.  Sean spent much of his life working with his hands Sean brought passion and dedication to all he did.  He was most at peace in God’s creation Sean’s love for the great outdoors was a reflection of his appreciation for the beauty of the world God made.  Sean is survived by his loving family: his siblings His kind heart and strong faith leave a lasting legacy for all who knew him.  An invite-only burial will take place on November 22nd Sean’s memory and the love he shared will live on in the hearts of his family and friends.  Sean has found eternal peace and joy in the kingdom of heaven Schumacher-Kish Funeral and Cremation Services - La Crescent LLC and respective content providers may receive compensation for some links to products and services on this website I honestly didn't know Patrick Ewing shoes were a thing I'm telling you that if I'm ever just casually standing next to a basketball goal and hear someone say Kelsey?" I hope it's Patrick Ewing wearing these shoes and I hope that he immediately dunks over me and breaks the rim before looking back at me to say: "Whoops." My bad. That fever dream is actually just that amazing old Snickers commercial that (apparently) lives rent-free in my head for the rest of my life.  Regardless, NBA legend Patrick Ewing has been selling re-released versions of the iconic shoes he wore back in the 1990s, as well as other stylish retro sneakers, since relaunching his Ewing Athletics brand in 2012 Ewing Athletics continues to thrive as the first independent basketball brand catering to a dedicated fanbase and honoring its rich heritage," says the company's website Featured below are two of the limited edition shoes currently on sale on the site in select sizes. Both are modified versions of Ewing Brand's 33 HI Retro sneakers.  the 33 HI is an exact retro of the 1990 original and features a classic reversible ankle strap that can be worn on the front or back of the shoe and a full-length PU midsole for cushioning," says the website the Big Pun x Ewing 33 Hi uses the color scheme from Pun’s debut album Capital Punishment it was the only album released during Big Pun’s lifetime (he tragically passed away at age 28) and was the first solo Latin hip hop record to go Platinum "This special edition collaboration was originally released in 2018 and sold out instantly we have brought it back for a limited time special branding and packaging from the original 2018 edition Everything from the leather to logos to the box has been upgraded to a premium level to complete the collector's edition feel." 47 out of 48 of the reviews for these shoes are five out of five stars and classic design," says another.  "To honor the legacy of Hip Hop pioneers Kid 'N Play we worked on a special 33 HI inspired by their debut album The black-and-white sneakers feature a black wool upper accented with white leather directly tying into the outfits Kid 'N Play rocked on the album cover Design details include Kid 'N Play’s logo on the tongue the number “2” replacing the signature “33” on the strap and the word “hype” added to the heel as a nod to 2 Hype we included colorful gradient laces for anyone in a house party mood and they come in a commemorative box to complete the tribute to their debut album." All 12 reviews for these sneakers are also five stars out of five and I love the throwback to my childhood," says another.  Ewing Athletics offers $9 flat-rate shipping for U.S Metrics details We have recently demonstrated that genetic inactivation of EWSR1 : : FLI1 by CRISPR/Cas9 successfully blocks cell proliferation in a cell model of Ewing sarcoma CRISPR/Cas9-mediated gene editing can exhibit off-target effects precise regulation of Cas9 expression in target cells is essential to develop gene-editing strategies to inactivate EWSR1 : : FLI1 in Ewing sarcoma cells we demonstrate that Cas9 can be specifically expressed in Ewing sarcoma cells when located downstream a promoter consisting of GGAA repeats and a consensus TATA box (GGAAprom) Cas9 is selectively expressed in Ewing sarcoma cells that express EWSR1 : : FLI1 oncoproteins but not in cells expressing wild-type FLI1 Ewing sarcoma cells infected with GGAAprom>Cas9 and a specific gRNA designed to inactivate EWSR1 : : FLI1 showed successful EWSR1 : : FLI1 inactivation and the subsequent blockade of cell proliferation GGAAprom>Cas9 can be efficiently delivered to Ewing sarcoma cells via adenoviral vectors both in vitro and in vivo highlighting the potential of this approach for Ewing sarcoma treatment Our results demonstrate that the CRISPR/Cas9 machinery is safe and specific for Ewing sarcoma cells when driven under a GGAAprom paving the way for the development of cancer gene therapies based on the selective expression of genes with therapeutic potential One way to improve specificity could include designing a molecular strategy in which the Cas9 nuclease is expressed exclusively and specifically in Ewing sarcoma cells This characteristic is exclusive to EWSR1 : : FLI1 and to our knowledge no other transcription factors have been shown to have similar characteristics which shares the same DNA-binding domain as EWSR1 : : FLI1 is not able to transactivate these GGAA repeat sequences we show that a minimal GGAA-based promoter which contains concatemerized GGAA repeats and a TATA-box (GGAAprom) is able to drive high Ewing-specific expression of a gene of interest Using Cas9 and specific sgRNAs designed to inactivate EWSR1 : : FLI1 as a therapeutic approach we demonstrated that this strategy is effective in vitro when lentiviral and adenoviral vectors are used as delivery strategies the use of adenovirus in vivo revealed that this strategy allows the expression of luciferase only in tumor cells but not in normal tissues we demonstrated that adenovirus harboring Cas9 under the regulation of the GGAA promoter were able to reduce tumor growth in vivo Our results justify additional preclinical research to advance in the development of this new gene therapy for Ewing sarcoma The Ewing sarcoma cell line A673 (CRL-1598) the fibrosarcoma cell line HT1080 (CCL-121) the osteosarcoma cell lines U2-OS (HTB-96) and Saos-2 (HTB-85) and the HEK293T cells (CRL-3216); were purchased from the American Type Culture Collection (Manassas MHH-ES1 (ACC167) and SK-N-MC (ACC203) were purchased from the DSMZ-German Collection of microorganisms and cell cultures (Braunschweig The Ewing sarcoma cell lines A4573 were generously given by Dr HEK293T and HT1080 cell lines were maintained in DMEM; A4573 MHH-ES1 and U2-OS were maintained in RPMI 1640; Saos-2 cell line was maintained in McCoy’s medium All media were supplemented with 10% fetal bovine serum 50 U/mL penicillin and 50 µg/mL streptomycin (Corning Cell lines were checked by STR profiling and periodically tested for mycoplasma contamination (Mycoalert mycoplasma detection kit The PCR product was purified and then cloned into pGEM-T Easy Vector (Promega Corp. USA) generating a consensus TATA-box during cloning GGAAprom fragment was subcloned by enzyme restriction and ligation into the pGL3-Basic luciferase reporter vector (Promega Corp.) Lentiviral plasmids encoding the luciferase protein LUC2 downstream different promoters (GGAAprom GGAAless and GGAAless/TATAless) were produced by Vector Builder (Chicago lentiviral plasmids include an EGFP:T2A:Bsd cassette under a CMV promoter for cell selection and monitoring of transfection MHH-ES1 and HT1080 cells were infected with lentiviral particles at two different MOI (0.5 and 5) and selected with blasticidin (50 µg/mL) To confirm similar levels of lentiviral transduction the percentage and intensity of GFP positive cells were quantified by flow cytometry with a MACS Quant Analyser flow cytometer (Miltenyi Biotec stable cell lines were seeded in triplicate in a 6-well plate at a density of 200,000 cells per well and cultured for 72 h cells were washed twice with PBS 1x and lysed in 500 µl of passive lysis buffer (PLB) (Promega Corp.) Protein concentration was determined with a Pierce microBCA™ protein assay kit (Thermo Fisher Scientific To avoid interference between the BCA reagents and PLB and the standard curve was prepared in PLB 0.1x 100 ng of total protein was used to measure the luciferase activity with the Luciferase Assay Reagent (LAR) (Promega Corp.) according to the manufacturer’s instructions Luciferase activity was measured in an Infinite M200 microplate reader (Tecan MHH-ES1 and HT1080 cells were infected with lentiviral particles (MOI = 5) encoding Cas9 under the control of GGAAprom (cell lines GGAAprom>Cas9) or GGAAless (cell lines GGAAless>Cas9) promoters HT10180 cells were also infected with lentiviral particles harboring Cas9 under the control of the constitutive promoter EFS (EFS>Cas9) a short version of the full-length EF1A promoter After selection with blasticidin (50 µg/mL) cells were sorted by flow cytometry to obtain a cell population with high levels of GFP expression Cas9 expression levels were confirmed by western-blot with an anti-Cas9-specific antibody (#Ab191468 cells were briefly selected with hygromycin (350 µg/mL) during 4 days and then seeded in replicate (1 × 103 cells per well) in 96-well black plates 4 and 7 days using a resazurin metabolic assay USA) were added to cells and incubated for 5 h at 37 °C Fluorescence was measured at 560 nm excitation/590 nm emission filter set in an Infinite M200 microplate reader (Tecan) Anti-mouse m-IgG-HRP (#sc-516102) and anti-rabbit IgG-HRP (#sc-2357) secondary antibodies were purchased from Santa Cruz Biotechnology (Dallas Genomic DNA was isolated from previously frozen cell pellets using the QIAamp DNA Mini Kit (Qiagen, Hilden, Germany). DNA fragments covering the gRNA target were amplified by PCR using the primers described in Supplementary Fig. S6 PCR amplicons were subsequently sequenced by Sanger sequencing and electropherograms were analyzed with the ICE CRISPR analysis tool (Synthego USA) to quantify the percentage of indel mutations Gene editing was also confirmed by T7 endonuclease assay PCR products obtained from genomic DNA were purified using the QIAquick PCR Purification Kit (Qiagen) and then 200 ng of the purified DNA was denatured for 5 min at 95 °C and afterwards allowed to align slowly using a first step consisting of a − 2 °C/s ramp rate from 95 to 85 °C and a second step consisting of a − 0.1 °C/s ramp rate from 85 to 25 °C 1 µL (10,000 UI/mL) of T7 Endonuclease I (#M0302 USA) were added to the re-annealed PCR products and incubated at 37 °C for 15 min T7 endonuclease reaction was stopped with 1.5 mM EDTA on ice The fragmented PCR products were analyzed by agarose electrophoresis and the percentage of nuclease-specific cleavage products quantified by densitometry (Fiji software) Adenoviral vectors containing an hPGK>mCherry cassette and the GGAAprom>LUC2 (pAd-hPGK>mCherry-GGAAprom>LUC2) or EF1A > LUC (pAd-hPGK>mCherry-EF1A > LUC2) cassettes were synthesized by Vector Builder Adenovirus were produced by the Viral Production Unit (VPU) of the Universitat Autonoma de Barcelona (UAB) (Barcelona Cells were seeded in triplicate in 96-well plates (3000 cells per well) and infected the next day with the aforementioned adenovirus at different MOI (25 cells were washed with 1× PBS and lysed in 50 µL of 1x passive lysis buffer (PLB) (Promega) at room temperature for 15 min with agitation Total protein and luciferase activity were measured following the protocol described above cells were seeded in 6-well plates and treated similarly with adenovirus to quantify mCherry expression by flow cytometry (BD LSRFortessa™ X-20 Cell Analyser Adenoviral vectors containing a reporter cassette (hPGK>mCherry) a gRNA expression cassette (U6 > FLI1_EX2 or U6 > FLI1_EX9) and a Cas9 expression cassette (GGAAprom>Cas9) were synthesized by Vector Builder Adenovirus were produced by the Viral Production Unit (VPU) of the Universitat Autonoma de Barcelona (UAB) Cells were seeded in 6-well plates (5000 cells per well) and the next day the medium containing the adenovirus was removed cells in replicate wells were trypsinized and counted using trypan blue solution and an EVE™ automatic cell counter (NanoEnTek Inc. and the pellets stored for protein and DNA extraction for western-blot and gene editing analysis respectively All experiments in animals were performed in 8 to 10-week-old athymic female nude mice (CR ATH HO strain France) and conformed to the Animal Welfare guidelines and protocols approved by the Animal Experimentation Ethics Committee of the Instituto de Salud Carlos III (CBA 25_2020 and CBA 24_2022) and Agriculture Department of the Madrid Region (PROEX 253.8/20 and PROEX 302.3/22) mice were injected intravenously with 1010 viral particles of adenovirus (pAd-hPGK>mCherry-GGAAprom>LUC2 or pAd-hPGK>mCherry-EF1A > LUC2) in 100 µL PBS with 100 μl of Xenolight™ Potassium Salt Bioluminescent substrate (15 mg/ml) (Perkin Elmer USA) and photographed in an IVIS Lumina XRMS (PerkinElmer) Images were acquired in automatic model and analyzed with the Living Image 4.8 software (Perkin Elmer) animals were euthanized and representative fragments of 12 different organs (spleen and brain) were frozen and stored at -80 °C until they were processed to quantify the luciferase activity in tissue protein extracts tissues were weighted and lysed in 1x passive lysis buffer (Promega) (750 µL lysis buffer/100 mg tissue) in tubes with ceramic beads (# CK-28R; Bertin Technologies France) in a Precellys Evolution tissue homogenizer (Bertin Technologies) (6,800 rpm Protein quantification and luciferase assays were performed as described above mice were inoculated subcutaneously with 5 × 106 A673 cells and when tumors reached a volume of 250 mm3 tumors were injected intratumorally with a unique dose of 109 viral particles in 100 µL PBS at 3- and 6-days post intratumoral inoculation was determined by IVIS imaging in whole animals as described above tumors were excised and luciferase activity in tumor lysates was quantified as above For efficacy studies of therapeutic adenovirus (those expressing Cas9 protein under the GGAAprom) mice were inoculated subcutaneously with 5 × 106 A673 and when tumors reached a determined volume animals were randomly distributed into two groups (PBS and treated group) To distribute the animals equally between both groups and avoid possible biases the animals were first ordered from largest to smallest tumor volume and then randomly distributed to one group or the other Animals were treated with three intratumoral injections at 48–72 h intervals Two independent experiments using two different doses of adenovirus were performed (1 × 109 VP/dose and 5 × 1010 VP/dose) Tumor growth was monitored each 2-3 days with a caliper and tumor volume was calculated as: ((length × width2) × π)/6 The number of independent experiments performed for each experiment is indicated in the corresponding figure legend a minimum of five animals per group were used and the exact number used per group is also indicated in the corresponding figure legend Statistically differences between means were calculated with one-way or two-way ANOVA or Student’s T-test as appropriate All statistical tests were two-sided and adjusted for multiple comparisons as appropriate Statistical analysis were carried out with GraphPad software P values < 0.05 were considered statistically significant HEK293T cells were co-transfected with the reporter vector pGL3 GGAAprom and the expression vectors pCIneo-EWSR1-FLI1 or pCIneo-FLI1 firefly luciferase activity was quantified and normalized to renilla luciferase activity EWSR1 : : FLI1 induced specifically the expression of the reporter gene luciferase (mean ± SD of one experiment done by triplicate) B Schematic representation of the different promoters used for lentiviral infections indicating the presence or absence of GGAA repeat region and TATA-box C A673 and MHH-ES1 Ewing sarcoma cells and HT1080 fibrosarcoma cells were infected at two different MOI with lentivirus harboring the luciferase reporter gene under the control of the promoters described in B) Luciferase activity in stably infected cells was quantified and normalized to cells infected with an empty vector High luciferase activity was observed in Ewing sarcoma cells infected with GGAAprom including the GGAA repeats and the TATA-box Luciferase expression was not observed in HT1080 infected with any construct (mean ± SD of three experiments) luciferase activity was slightly lower in A673 cells infected at an MOI of 0.5 than in the same cells infected at an MOI of 5 with GGAAprom luciferase activity was even greater in MHH-ES1 cells than in A673 cells infected with GGAAprom which contains a GGAA-rich region and a linked can be efficiently activated by EWSR1 : : FLI1 in A673 and MHH-ES1 Ewing sarcoma cells but not in HT1080 cells which express high levels of the native FLI1 protein This characteristic makes GGAAprom particularly suitable as a specific promoter for gene therapy in Ewing sarcoma because of its high specificity for EWSR1 : : FLI1 A Cas9 expression in A673 and MHH-ES1 Ewing sarcoma cells and HT1080 fibrosarcoma cells stably transduced with GGAAprom>Cas9 GGAAless>Cas9 and EFS>Cas9 lentivirus High levels of Cas9 expression were specifically achieved in Ewing sarcoma cells infected with GGAAprom>Cas9 B Effect of gRNA FLI-EX2 and FLI1-EX9 on cell proliferation Stably transduced cells were additionally infected with lentivirus harboring a gRNA against FLI1 exon 2 (negative control) or a gRNA against FLI1 exon 9 which causes the genetic inactivation of EWSR1 : : FLI1 The effect on cell proliferation was monitored for 7 days Cas9 expression combined with gRNA FLI1-EX9 blocked cell proliferation only in Ewing sarcoma cells (mean ± SD of a representative experiment from a total of three; ****P < 0.0001 sgRNA directed against FLI1 exon 2 can be used as a control sgRNA in Ewing sarcoma cells because this FLI1 exon is not included in the EWSR1 : : FLI1 fusion and Ewing sarcoma cells do not express native FLI1; thus editing at this exon is not deleterious for Ewing sarcoma cells an RNA guide targeting FLI1 exon 9 affects the DNA-binding domain of FLI1 which is an essential region for EWSR1 : : FLI1 function no effects on cell proliferation were observed when GGAAprom>Cas9 or EFS>Cas9 HT1080 cells were infected with FLI1 exon 2 or exon 9 gRNAs These results demonstrate that the combination of Cas9 under the control of an Ewing-specific promoter (GGAAprom) and a gRNA targeting exon 9 of FLI1 is sufficiently efficient to block cell proliferation in Ewing sarcoma cells while lentiviral vectors are excellent proof-of-concept tools the use of a lentiviral-based approach to deliver gene therapy to Ewing sarcoma cells is not suitable for clinical development we decided to explore the use of adenovirus as a suitable alternative to deliver gene therapy to Ewing sarcoma cells Although adenoviruses have several drawbacks they remain one of the most commonly used viral vectors in cancer gene therapy with higher transduction efficiencies observed at higher MOI A Luciferase activity in cells infected with adenovirus (MOI = 100) harboring a constitutive promoter (EF1A > LUC2) or the Ewing specific promoter (GGAAprom>LUC2) GGAAprom was only active in Ewing sarcoma cells (red bars) (mean ± SD of a representative experiment from a total of three) Ad EF1A > LUC2 (n = 4) or Ad GGAAprom>LUC2 and luciferase activity quantified by IVIS imaging 72 hours post-injection No luciferase activity was observed at all in mice injected i.v C Quantification of luciferase activity in tissue extracts Twelve different tissues were extracted from each animal and the corresponding protein lysates were analyzed for luciferase activity Each point represents the luciferase activity obtained in one animal (mean ± SEM) D Luciferase expression in tumors injected i.t Luciferase activity was detected in Ewing sarcoma tumors injected with Ad-EF1A > LUC2 (constitutive expression) and Ad-GGAAprom>LUC2 (Ewing-specific expression) Luciferase activity in tumor tissue lysates is also shown Each point represents the luciferase activity obtained in one tumor (mean ± SEM) These findings strongly support that gene therapy based on the expression of a therapeutic gene under the control of the GGAAprom could represent a therapeutic strategy with remarkable specificity for Ewing sarcoma cells without impacting normal cells of the organism tumors injected with either Ad-EF1A > LUC2 or Ad-GGAAprom>LUC2 exhibited high levels of luciferase activity These results indicate that Ad-GGAAprom>LUC2 is able to infect Ewing sarcoma cells in vivo and efficiently induce the expression of a gene of interest upon reaching the target tissue A Effect of Ad-GGAAprom>Cas9/gRNA EX2 and EX9 on cell proliferation SK-N-MC and HT-1080 cells were infected with the mentioned adenovirus (MOI = 25) and cell proliferation was monitored by cell counting Cell proliferation was severely impaired in A673 and SK-N-MC Ewing sarcoma cells infected with Ad-GGAAprom>Cas9/gRNA EX9 (mean ± SD of a representative experiment from a total of three and EWSR1 : : FLI1 target genes CD44 and NR0B1 following adenovirus infection (MOI = 100) Treatment with Ad-GGAAprom>Cas9/gRNA EX9 dramatically reduced EWSR1 : : FLI1 expression concomitantly affecting the expression of EWSR1 : : FLI1 target genes CD44 and NR0B1 C Effect of adenovirus infection on cell morphology with A673 cells and split into two groups on day 19 The group treated with adenovirus received intratumoral injections of Ad-GGAA>Cas9/gRNA EX9 at days 19 Control group received intratumoral PBS (n = 5) Tumor volume and tumor volume normalized to day 19 (start of treatment) for each animal are showed adenovirus treatment (5 × 1010 VP/dose) was started on day 9 (n = 8) and administered at days 10 Control group received intratumoral PBS as above (n = 7) Tumor volume and tumor volume normalized to day 9 (start of treatment) for each animal are showed A significant reduction in tumor growth was observed in the treated group (*P < 0.05; two-way ANOVA) and gene editing was quantified by ultra-deep next generation sequencing Significant gene editing was observed in animals treated with 5 × 1010 VP/dose (mean ± SEM; ****P < 0.0001 A Tumor sections were stained with an anti-Ki67 antibody to assess cell proliferation Graph shows percentage of Ki67+ cells in control animals (PBS n = 5) and animals treated with 5 × 1010 VP/dose of Ad-GGAAprom>Cas9/gRNA EX9 (Ad-Cas9-EX9 B Representative tumors for each group stained with Ki67 antibody (bar = 100 µm) Ewing sarcoma is a devastating rare tumor affecting children and young adults for which the development of new therapeutic strategies is imperative Ewing sarcoma is characterized by tumor-specific chromosomal translocations that produce tumor-specific fusion proteins such as the oncogenic chimeric transcription factor EWSR1 : : FLI1 Ewing sarcoma cells are addicted to these EWSR1 : : FLI1 fusion oncoproteins; thus any approach aimed at blocking or inactivating EWSR1 : : FLI1 is expected to interfere with tumor growth Another possible strategy to interfere with EWSR1 : : FLI1 function is the use of siRNAs to knock down EWSR1 : : FLI1 expression This strategy has been extraordinarily successful for the generation of cell models of EWSR1 : : FLI1 knockdown which have been very helpful for understanding the biology of Ewing sarcoma potential therapies based on the use of siRNAs designed to knockdown EWSR1 : : FLI1 mRNAs have the same drawbacks as those described above concerning the use of small molecules designed to block EWSR1 : : FLI1 function to achieve the best EWSR1 : : FLI1 inactivation genetic inactivation of the EWSR1 : : FLI1 gene exquisite control of Cas9 expression must be achieved to rule out any unwanted effects on normal cells we demonstrate that this precise and exquisite control could be achieved by using an Ewing-specific promoter formed by concatenated repeats of the tetranucleotide GGAA (GGAAprom) the use of a consensus TATA box downstream of the GGAA repeats increased the activity of the promoter by 2–3 times compared to that of the GGAA repeats only The high specificity of this DNA sequence for Ewing sarcoma cells was demonstrated both in vitro and in vivo GGAAprom was active in Ewing sarcoma cells expressing EWSR1 : : FLI1 proteins (A673 which encompass three different EWSR1 : : FLI1 isoforms) but not in non-Ewing sarcoma cells such as the fibrosarcoma cell line HT1080 or the osteosarcoma cell lines U2-OS and Saos-2 The absence of GGAAprom activation in HT1080 cells is particularly relevant because these cells express high levels of native FLI1 indicating that GGAAprom is only active in Ewing sarcoma cells expressing EWSR1 : : FLI1 This important finding was soundly confirmed in in vivo experiments when athymic nude mice were injected intravenously with adenovirus harboring a luciferase gene under the control of GGAAprom no luciferase expression in any of the 12 tissues analyzed was detected This means that a gene therapy in which the therapeutic gene is under the control of the Ewing-specific promoter will be active only in Ewing sarcoma cells expressing EWSR1 : : FLI1 This opens the possibility of using this type of approach with a multitude of therapeutic genes that may include not only nucleases such as the one proposed in this work to inactivate EWSR1 : : FLI1 but also genes capable of inducing cell death (for example suicide genes) or immunomodulatory genes capable of activating an antitumor immune response still one or two orders of magnitude higher than that used in our preclinical animal studies This indicates that there is still room to use higher doses that would have yielded even more remarkable results further experiments with higher doses were not possible due to the limitation in the amount of adenovirus produced the authors use a complex strategy for in vivo delivery based on the use of lentiviral vectors and an adapter antibody that can make more difficult its preclinical development Although in vivo gene editing certainly presents numerous risks that must be carefully considered the development of highly specific expression strategies such as the one presented in this work opens new opportunities to permanently inactivate the EWSR1 : : FLI1 fusion gene characteristic of Ewing sarcoma we reported a gene therapy approach to permanently inactivate EWSR1 : : FLI1 in Ewing sarcoma cells in a highly specific way no other approach has been shown to inactivate so effectively We believe the results shown here support the use of this strategy to treat Ewing sarcoma and justify continuing its preclinical development The data presented in this study are available from the corresponding author on reasonable request International randomised controlled trial for the treatment of newly diagnosed EWING sarcoma family of tumours - EURO EWING 2012 Protocol Comparison of two chemotherapy regimens in patients with newly diagnosed Ewing sarcoma (EE2012): an open-label Ewing Sarcoma: Current Management and Future Approaches Through Collaboration The second European interdisciplinary Ewing sarcoma research summit-A joint effort to deconstructing the multiple layers of a complex disease Systematic review of phase-I/II trials enrolling refractory and recurrent Ewing sarcoma: Actual knowledge and future directions to optimize the research Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours Systems biology of Ewing sarcoma: a network model of EWS-FLI1 effect on proliferation and apoptosis is a principal regulator of cell-cycle progression in Ewing’s tumor cells a Direct Target of EWSR1-FLI1 in Ewing Sarcoma Cells Regulates the Expression of Neural-Specific Genes EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1 Sequence-specific knockdown of EWS-FLI1 by targeted nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing’s sarcoma EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3 Advances in targeting EWS/FLI-1 fusion in Ewing sarcoma as novel therapy Therapeutic Potential of EWSR1-FLI1 Inactivation by CRISPR/Cas9 in Ewing Sarcoma Recent Advances and Therapeutic Strategies Using CRISPR Genome Editing Technique for the Treatment of Cancer Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy CRISPR-Cas: a tool for cancer research and therapeutics The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors Hormonal and developmental regulation of DAX-1 expression in Sertoli cells CRISPResso2 provides accurate and rapid genome editing sequence analysis QuPath: Open source software for digital pathology image analysis CD44 Modulates Cell Migration and Invasion in Ewing Sarcoma Cells Targeting the EWS-FLI1 transcription factor in Ewing sarcoma Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus Identification of an Inhibitor of the EWS-FLI1 Oncogenic Transcription Factor by High-Throughput Screening 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Recombinant Adenoviral Vectors in Preclinical and Clinical Applications Review of Safety Data for Adenovirus 5 as a Delivery Vector for Intratumoral Cancer Gene Therapy CRISPR/Cas9 technology as a potent molecular tool for gene therapy Implications of CRISPR/Cas9 system in Hypertension and its related diseases CRISPR/Cas9 and next generation sequencing in the personalized treatment of Cancer Download references We thank patient associations Asociación Pablo Ugarte Asociación Candela Riera and Fundación FEDER for their continued support to our laboratory We also thank Genomic and Animal facilities of the ISCIII for technical assistance This work was supported by Instituto de Salud Carlos III (PI20CIII/00020 Asociación Todos somos Iván and Asociación Candela Riera (TVP 333/19) and Fundación FEDER (SIVI 124/24) RMFdM was supported by a contract of CIBERER-ISCIII Instituto de Investigación de Enfermedades Raras Melero-Fernández de Mera & Javier Alonso Centro de Investigación Biomédica en Red de Enfermedades Raras Instituto de Salud Carlos III (CB06/07/1009; CIBERER-ISCIII) Instituto de Investigación Sanitaria HM Hospitales STC designed and performed the experiments analyzed the results and helped to write the manuscript and to prepare the figures analyzed the results and prepared the figures RMFdM contributed to design experiments and reviewed the manuscript The authors declare no competing interests Experiments with animals were performed according to Animal Welfare guidelines and were approved by the Animal Experimentation Ethics Committee of the Instituto de Salud Carlos III (CBA 25_2020 and CBA 24_2022) and the Agriculture Department of the Madrid Region (PROEX 253.8/20 and PROEX 302.3/22) Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41417-025-00887-8 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Jacob Ewing is a senior in engineering management with an emphasis and minor in explosives engineering and leads the cadets in S&T’s Army ROTC Stonehenge Battalion Jacob Ewing is determined to become a successful leader once he graduates from Missouri S&T. Through academic excellence and leading cadets in S&T’s Army ROTC Stonehenge Battalion “I’m involved in basically every opportunity that you can be involved in,” Ewing says “I just have this philosophy: I always want to be better tomorrow than I am today He will graduate twice this year: earning a bachelor’s degree in May and a master’s degree in December.   Both of Ewing’s grandfathers were military officers (Army and Air Force) Ewing says they passed away before seeing him choose the military Ewing’s path to the military has certainly been a busy one.  Ewing’s first college year began with glowing success. Along with getting involved in the ROTC color group, the cannon crew and various campus clubs, Ewing excelled in the Ranger Challenge a military skills competition for the nation’s military academies and ROTC programs.   The final competition, the Sandhurst Military Skills Competition comprises the top 16 ROTC teams in the nation plus 15 international teams and military academies The task force and brigade competitions determine which 16 ROTC teams advance to Sandhurst Ewing’s team won the task force competition and placed second in the brigade competition held at the United States Military Academy at West Point “We became the first school in Missouri to make it to Sandhurst,” Ewing says “It was the first time in our school’s history that we ever made it to an international competition of that caliber.”  Ewing’s summer following his first year of college was just as busy. Ewing completed an internship with the United States Army Corps of Engineers, where he worked at Fort Leonard Wood on a hospital replacement project.   “I worked as a quality control and quality assurance engineer with Major Steven Lanni and saw how the Army Corps of Engineers operates in the engineering regiment itself,” Ewing says.   Sophomore year: Developing solutions  In addition to serving as the chair of a national scholarship committee Ewing became more involved during his sophomore year as a team leader within S&T’s Stonehenge Battalion By earning the highest combat fitness test score at S&T he achieved the role of master fitness trainer in which he developed personal training plans and curriculum for S&T cadets.   He became involved in the recruiting committee and even developed a software program that helped recruit more cadets.  “That software I helped develop — that’s some of the knowledge I got from my degree that really helped our program,” Ewing says “It basically automated our process that we already did but just streamlined it and made it more efficient so we didn’t have to do it the old way with a pencil.”  In recognition of his service to the campus and community named for a professor of engineering management at Missouri S&T for over 30 years.   he completed a course at the University of North Carolina through Project Global Officer to learn Mandarin Chinese in just two months.  He learned how to safely jump out of an airplane wearing a parachute.  “I did jump school because one of my biggest fears is heights but how I’ve defined myself is I want to do the things that I’m the most scared of That was my way of conquering what I was most afraid of.”   he became captain of the Ranger Challenge team and a platoon sergeant within the battalion.   Year three is primarily preparing students to get ready for cadet summer training Ewing joined Missouri S&T’s eSports club and became an officer in the American Society for Engineering Management (ASEM) Myers Scholarship to help determine the next recipient.  Ewing attended cadet summer training in Fort Knox He was evaluated on individual military skills and his ability to lead a platoon of 40 cadets through a rigorous field exercise 1 out of 640 cadets that participated in his regiment This exceptional performance contributed to his ranking as No 13 out of 5,140 cadets in his graduation year group from across the nation.  From there Ewing flew to Fort Lewis in Washington to complete another internship in the 46th Aviation Support Battalion He worked with the Multi-Domain Effects Battalion “I was learning how to be an officer in a real-life environment,” Ewing says learning signal operations such as how we secure our communication networks across the Pacific Ocean.”  Ewing became the cadet battalion commander the highest officer position available for a cadet — and leads 56 cadets.  “Being a battalion commander basically means that you assume all responsibility,” he says “Any training that we conduct is 100% on me to make that decision.”  Ewing explained that he thinks of big ideas for the battalion then ensures those ideas happen by bringing them to his staff who then push it all the way down to each leader.  “The major reason why I like leading is developing others and seeing other people succeed,” Ewing says “That’s been my primary motivator for ROTC and being a leader within the organization.”  Ewing said his senior year has been especially validating — this is the year they get back all of their results everything a student does in their first three years is tabbed and put into an order of merit score then an order of merit list where they get stacked against all 6,000 cadets across America.  11 in the entire country out of all 6,000 cadets that competed in my year group,” Ewing says.   he had the benefit of choosing where his future path goes he was officially awarded Cyber (the US Army Cyber Command) as his branch “It’s a cool honor to have the hard work over the last four years awarded,” Ewing says “I would enjoy going to work at the National Security Agency or to work for a multi-domain task force protecting national security for the country the spearhead of the future of the military is where I want to put myself because while they are one of the most rigorous and time-consuming jobs; they are the future.”  Ewing said not only did S&T’s ROTC program help lead him toward his future in leadership but his academic programs also played a major part ROTC was the thing that glued all of it together and connected all the dots I’ll take that experience that I learned about being technical and take it into the military as a leader.”  teaching professor and associate chair for undergraduate studies in engineering management and systems engineering was a pivotal part of Ewing’s success as his advisor She noticed his leadership potential early on.  regardless of whether he stays in the Army or whether he transfers into the civilian world because that’s just who he is,” Schuman says “He’s not one of those leaders that comes in and tells everybody what to do Schuman says problem-solving and critical thinking are the top skills the program focuses on.  “Our program is a little different from other engineering programs,” Schuman says “We try to look at the whole picture and how everything fits together I think that we’ve provided that for him and I think the Army ROTC has also provided a different piece of that.”  says he’s proud of how much Ewing has grown as a leader in the past few years.  “I think one of the coolest things about him is he’s not just really good at academics and he does it all effortlessly,” Weir says “But the biggest thing for me is that he does it with empathy and he cares for his soldiers and his people I think that truly will help him rise to the top.”  former professor of military science at S&T he gave Ewing a very meaningful review.  “The best cadet I have observed in five years in the U.S and his extra effort is demonstrated by his top accomplishment marks…(he’s) an exceptional young leader who will make a difference in our Army.”  “The part where he said I was the best cadet he had seen in five years in the cadet command stands out as the greatest remark anyone has ever said about me,” Ewing says “He had worked in ROTC for five years and saw thousands of cadets which makes that comment very touching … It really showed me that all my hard work paid off and motivated me to continue doing the best I could.”  Ewing plans to become an officer in the Army’s Cyber branch and hopes that his influence as a leader will help develop others.  “I’ll never define my success as an Army officer based on my personal achievements but on the achievements of those I developed and led,” Ewing says then I will define my career as having been successful.”  and website in this browser for the next time I comment Jacob is an exceptional young man and his empathy for others truly defines him Tatum is the former President of Spelman College and will speak at Millikin on Feb DECATUR, Ill. – Millikin University is pleased to welcome New York Times-bestselling author and award-winning psychologist Dr. Beverly Daniel Tatum for the Spring 2025 Thomas W Tatum is the author of the New York Times best-selling book “Why Are All the Black Kids Sitting Together in the Cafeteria and Other Conversations About Race” as well as “Can We Talk About Race and Other Conversations in an Era of School Resegregation.”   Tatum’s presentation will be titled “Closing the Gap: Embracing Cross-Racial Dialogue." This event is free and open to the public An award-winning psychologist widely known for her expertise on race relations and as a thought leader in higher education Tatum is President Emerita of Spelman College Her 13 years as the President of Spelman College (2002-2015) were marked by innovation and growth and her visionary leadership was recognized in 2013 with the Carnegie Academic Leadership Award Haas Distinguished Visitor at Stanford University she served as interim president at Mount Holyoke College during the 2022-23 academic year The combination of Tatum’s expertise and engaging conversational style has made her a sought-after speaker on higher education leadership strategies for creating inclusive campus and work environments and the impact of race in the classroom.  degree in Psychology from Wesleyan University in Clinical psychology from the University of Michigan in Religious Studies from Hartford International University (formerly Hartford Seminary) She was the 2014 recipient of the American Psychological Association Award for Outstanding Lifetime Contributions to Psychology.  About the Thomas W Ewing Lectureship was created by Millikin and Congressman Ewing’s colleagues in recognition of his many years of public service retired in 2001 after serving nine years in the U.S House of Representatives from the 15th District of Illinois The lectures focus on public policy and service and visiting lecturers are selected based on their prominence in those fields and ability to inspire others to serve.  View Visitation & Service details > Sherry had worked in the finance areas at the Penn National Race Course in Lancaster until her retirement She was a devoted mother of four and grandmother of five and had many interests over the years Sherry loved to work with her hands and create ranging from artistic details inside her home to building an entire sun room from the ground up Sherry is survived by her four children: Stephanie Ewing of Leola Ryan married to Jennifer Ewing of Pittsburgh Shannon married to John Frelak of Lancaster and Tess Ewing married to Joe Keller of Philadelphia; her 5 grandchildren: Jolie and Josslynn Rohrer and Tripp Ewing; and by her siblings: Steve married to Deb Conrad Friends may visit with Sherry’s family from 2-3PM on Saturday PA with the Memorial Service to follow at 3PM please make contributions in Sherry’s memory to the Alzheimers Assn Condolence Message: Be sure to include your name Please note that your condolence will not appear on this page until it is reviewed Condolences usually appear within 24 hours of being submitted I’m so sorry to hear of the family loss.  Just remember Sherry is at peace.  Remember the good times.  The memories can not be forgotten I know nothing said can to take this feelling of loss from you but know you and your family are in my heart and prayers. Love Kim Sherry and I have a saying-” Best neighbor ever!” Love you,Sherry!! Our seven funeral homes in Lancaster and Lebanon Counties makes it easy and convenient to make arrangements and host services close to home After five years of unprecedented success as Vice President of Advancement and Chief Executive Officer of the Boise State University Foundation Matthew Ewing has announced he will return to his alma mater to become Senior Vice President for Development of the Indiana University Foundation “I am so grateful to Matthew Ewing for his incredible impact as a leader and on our community His extraordinary outcomes will affect students and staff for generations at Boise State University,” said Dr “He led our fundraising team through three consecutive record years launched our largest philanthropic campaign in university history and built relationships and structures that set us up for many successes to come His work and commitment to Boise State have directly benefited our student scholarship senior associate vice president for development Her experience will help ensure a seamless transition and I appreciate her willingness to serve our university in this capacity.” the foundation launched Unbridled: The Campaign for Boise State University The Unbridled campaign has raised $363.2 million of its $500 million goal to support student access and success faculty innovation and what’s next for athletics This has included nearly $70 million for endowed scholarships the creation of 10 new endowed faculty positions and $136.2 million for athletic initiatives “Matthew has been an instrumental leader for all of us expertise and even friendship,” said Jim Martin Executive Chair of the Boise State University Foundation Board of Directors “He has led with true unbridled Bronco spirit showing us all not only how to dream big about the foundation’s potential impact but also how to make that vision a reality and we wish him continued success as he returns to his alma mater We are confident Argia will maintain the foundation’s momentum I appreciate her assuming the interim role and leading us into this new chapter.” Beristain has been with the university for over 10 years working closely with Ewing and overseeing key campaign fundraising strategy The search for a new Foundation CEO will be facilitated by the foundation’s board More information on the Boise State University Foundation and the Unbridled campaign can be found at boisestate.edu/giving Beverly Daniel Tatum is a New York Times bestselling author and award-winning psychologist DECATUR, Ill. – Noted psychologist and New York Times bestselling author Dr. Beverly Daniel Tatum took the stage at Millikin University’s Albert Taylor Theatre on Wednesday, February 26, for the Spring 2025 Thomas W. Ewing Lecture sharing her message about the importance of embracing discussions about race and identifying the struggles that many have in the United States to engage in that conversation.  and Other Conversations in an Era of School Resegregation.”  Her presentation for the Ewing Lecture was titled “Closing the Gap: Embracing Cross-Racial Dialogue."  Tatum shared that many white people listen to discussions on racial topics but are often uncomfortable sharing their thoughts and experiences asking if they had experienced a racially centered event as a child and if they were able to speak about it with an adult afterward A portion of the audience hadn’t had a follow-up conversation and Tatum argued that not having those conversations strengthens the idea that some racial topics are not for some people.  “I've had many conversations about race; I do it professionally If I'm conversing with someone who's never done it It may feel like it's not a peer-to-peer conversation but it might feel more like a teacher and a learner,” Tatum said “I have a friend who has an expression that I love: There's a teacher and a learner in every student Even if I'm talking to someone who hasn't had as much practice as me I still have something to learn from that person white people in cross-racial dialogues think they don't have anything to share and they enter into that conversation only wanting to listen From the point of view of the students of color if we're talking about a topic that is important to me as a student of color and the white students in my class are not saying anything that makes me feel like they don't care and aren't interested Tatum served as President of Spelman College from 2002 to 2015 and her upcoming book to be released September 2 “Peril and Promise: College Leadership in Turbulent Times,” delves into the challenges that higher education faces while also acknowledging that colleges also provide the solutions to the divisions that disrupt our society.  many people say that our society feels highly polarized you might have voted for somebody different than me but I'm willing to spend the next 15 weeks meeting (in a class) with you and others to listen and share,” Tatum said You are learning something you didn't know before you will begin to get sick of this subject “That's what I'm calling the "Argument of Discomfort." If you weren't required to attend You get to the point where you're able to talk about it in the company of people you've come to trust because you've been sitting with them for several weeks and visiting lecturers are selected based on their prominence in those fields and ability to inspire others to serve This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Posted by | Apr 29 respectively) and will now head to High-A Brooklyn 1 BB in eight innings) have been promoted from High-A Brooklyn to Double-A Binghamton against the Worcester Red Sox this past week but they rallied to win the final three games including the series finale in which they won by an astounding score of 20-12 Singleton batted .360 for the series and had an OPS of 1.067 Billy McKinney also had a solid series The former major league Met has not had a strong start to the season but could look to build off the momentum of this last series Baty naturally made an impact in his first game The best start from a starting pitcher in this series came from Brandon Waddell It wasn’t a particularly strong start as he allowed two runs (one earned) in just four innings Waddell owns a 1.54 ERA through five starts Kevin Herget made an impression out of the bullpen tossing four scoreless innings over two appearances The veteran owns a 3.72 ERA through nine appearances Photo by Bronson Harris of Binghamton Rumble Ponies the Binghamton Rumble Ponies also had to play seven games this past week They had more success than their Triple-A friends including the first four in the series against the New Hampshire Fisher Cats The series win has the Rumble Ponies at 12-8 on the season Ryan Clifford had an up-and-down week but three of his four hits went for extra bases (two home runs and a double) Clifford has a low average and has struck out 25 times in 62 at-bats this season but he’s raised his OPS to .786 as he looks to get going Nick Morabito had a strong week and a home run with three RBIs and two stolen bases The speedster had been off to a slow start in his first taste of Double-A Jonah Tong had an excellent week on the mound displaying the swing-and-miss stuff that made him a breakout prospect a year ago Tong made two starts and allowed two runs (one earned) in 8 1/3 innings while striking out a ridiculous 19 batters Tong lowered his ERA this year to 3.63 and now has 30 strikeouts in 17 1/3 innings Zach Thornton and Ryan Lambert will join this productive pitching staff following their promotions The Brooklyn Cyclones played just five games this week The Cyclones won the series against the Jersey Shore BlueClaws three games to two dropping the series opener and finale but winning the middle three games Carson Benge and Eli Serrano III two of the Mets’ highly touted 2024 draft picks Benge went 6-for-19 with a home run and four RBIs Serrano has fared better than Benge in the early going owning an OPS over .100 points higher (.826 to .725) Estarling Mercado also continued his fast start to the year He had just a .665 OPS between Low-A and High-A ball in 2024 R.J. Gordon struck out nine and allowed just one run in five innings during his start against Jersey Shore who made his first pro ball appearance this year has a 2.70 ERA through four appearances with Brooklyn Díaz allowed just two hits and struck out five while Hall allowed seven hits and two walks with four strikeouts Both pitchers have been fantastic this year with Díaz not allowing a run through his first 15 2/3 innings while Hall owns a 1.45 ERA through four starts and Chandler Marsh will get their first taste of baseball above the Low-A level Lucie Mets took four of six games from the Daytona Tortugas this past week It was a great week for the pitching staff who allowed more than three runs in just two of the six games and four steals in just five games against Daytona Kevin Villavicencio also had an excellent week though just one (a double) went for extra bases and he now has a .394 average and .945 OPS in nine games with St Nate Dohm made two excellent starts in the series and he also allowed six hits and three walks Edgar Moreta held the Tortugas scoreless in his start going five innings and allowing just two hits while striking out three Moreta has struggled and owns a 4.97 ERA through four appearances Perhaps the most interesting start in St. Lucie this past week came from Raimon Gomez who is not just one of the hardest throwers in the Mets’ system but in all of professional baseball but the most notable stat from his start was that he reached a ridiculous 104.5 miles-per-hour with his fastball in the first inning AVG – Marco Vargas (STL)/Kevin Villavicencio (STL/BRK) – .409 SO – Blade Tidwell (SYR) – 37 giving the Mets no choice but to promote him Ewing will likely hit an adjustment period heading to Brooklyn but his development has been a pleasant one so far for the Mets He hadn’t been off to the best start to the year but his two starts in this last series cemented why the Mets are so excited about his potential Tong is still just 21 years old and will look to continue to establish himself as one of the best pitchers on the Mets’ farm in 2025 Copyright © 2005 - 2023 Metsmerized Online | Designed & Developed by WP CLINICS Restaurant Brings Approximately 80 Jobs to Community Donates $25,000 to Address Food Insecurity  The Chick-fil-A PlayTM  App is your home for free games and activities designed to create more time with your favorite people A network of correspondents providing impartial news reports and analysis in 33 languages from locations around the world Up-to-the-minute news and analysis from around the world and in Chicago Hosted by WBEZ's Mary Dixon and NPR's Steve Inskeep Newshour is the award-winning flagship program of the BBC World Service the world’s largest news gathering operation 1A convenes a conversation about the most important issues of our time smart reflection on world news as it’s happening innovators and artists from around the globe with news from Chicago from WBEZ’s Lisa Labuz Reset digs into how the news 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and Latif Nasser author and sociologist Eve Ewing makes the argument to phase out the ‘carceral logics’ she sees in classrooms nationwide Please check your inbox for your confirmation By subscribing, you agree with WBEZ’s Terms of Use and Privacy Policy Most people would say to teach children to meet their potential and to prepare for the world But in her new book Original Sins: The (Mis)education of Black and Native Children and the Construction of American Racism Chicago author and sociologist Eve Ewing presents readers with an exhaustively researched history of how U.S schools have instead been a place where separation and inequality have been enshrined by design Reset checks in with Ewing to explore the role of schools in America and a better way forward author of Original Sins: The (Mis)education of Black and Native Children and the Construction of American Racism Sarah Kellam is a Kentucky native and played collegiate golf at Northern Kentucky University She currently serves as a Manager of Digital Content and prior to the LPGA Sarah worked as a freelance content creator He was a SPEC-4 1st armored division in the U.S When he returned to Sulphur he worked as a roughneck in the Oilfield Industry He later worked as a custodian at First Baptist Church in Sulphur for 35 years Eddie collected coins and stamps and spent many enjoyable hours with his collections Eddie was preceded in death by the love of his life Henrietta (Estelle) Sallier Ewing; his parents Catherine Ann (Cathy) Ewing Caldwell and Jane Ewing Dutil; and his brother Teddy James Ewing and Jack Lee Ewing of Sulphur; and his sister Joan Ewing Dupre of California; and numerous nieces and nephews Cremation has been entrusted to Johnson Funeral Home of Sulphur