2025 12:25 am IDTGet email notification for articles from Gideon Levy FollowMay 4 2025 12:25 am IDTSometimes it's hard to believe what one is reading: Foreign Minister Gideon Sa'ar is calling on the international community to "fulfill its role in protecting minorities in Syria and to not turn a blind eye to the grave incidents taking place there." ShareSaveCommentInnovation GamingLeak Reveals ‘Destiny 2: Edge Of Fate’ Release Date, New LocationByPaul Tassi Forbes contributors publish independent expert analyses and insights movies and the internet.Follow AuthorMay 04 11:46am EDTShareSaveCommentThe Edge of Fate but now with full information about what it contains including some additional reveals like the Edge of Fate release date and the second expansion contained within the bundle and The Edge of Fate really is launching when the current Episode 3 battle pass ends At this point I very much doubt that’s a placeholder with the reveal this week It also somewhat aligns with the ~1.5 years between Destiny expansions considering The Final Shape was out in June of 2024 It is miles away from Marathon on September 23 but that will no doubt be closer to the second expansion Behemoth is reportedly officially called “Renegade” according to the Collector’s Edition info While the codename Apollo played into the “Year of Prophecy” title of this first Frontiers year I’m having a bit of trouble connecting Renegade to anything at present The Collector’s Edition isn’t anything all that unusual indicates that the “normal” bundle is likely still going to be $100 given that the CE price matches the Final Shape CE price This is despite having less content overall with two smaller expansions and no actual seasons You’re paying for those two expansions and what looks like four battle passes I know some players were hoping a year of content would get cheaper but considering we’re entering the era of $80 “normal” games Unscramble The Anagram To Reveal The Phrase The CE also confirms that the new location of the Edge of Fate expansion will be Kepler Kepler is said to be a “planetoid on the edge of Sol” and it appears it will be a desert-focused zone I’m somewhat confused about the Kepler idea Kepler planets are named after the Kepler telescope that finds them attempting to find earth-like elsewhere in the Milky Way It’s named after the 16th century astronomer Johannes Kepler But if this one is at the “edge of Sol” it would appear to be something different as these other Kepler planets are light years away We will learn more about all this on Tuesday it’s not like we’ve seen any real gameplay or dived deep into the concept The ping pong balls will be hopping tonight another piece of the offseason puzzle will be in place for the Blue Jackets The NHL’s annual draft lottery will take place this evening and be televised live on ESPN at 7 p.m. with the Blue Jackets finding out where they will select with their pick in the first round of June’s NHL draft The two lottery draws will determine the first and second overall selections in the draft Columbus is not in the running to get the No The Blue Jackets enter the draft with the 13th best odds to win the lottery by virtue of their 40-33-9 record and 89 points which left them two shy of the final playoff spot in the Eastern Conference But in what many experts feel is a top-heavy draft moving up would give the Jackets a strong chance to draft an impact player to add to a young squad that finished just shy of postseason play in 2024-25 Columbus’ 89 points place the squad with the fourth-best record of the 16 teams to fall short of the Stanley Cup Playoffs Vancouver and Utah finishing ahead of the Blue Jackets the Blue Jackets have just a 2.0 percent chance of winning the first lottery draw One year after taking Macklin Celebrini first overall San Jose still had the league’s worst record and has the best odds (18.5 percent) of winning the lottery draw again the New York Rangers (3.0 percent) and Detroit (2.5 percent) Vancouver (0.5 percent) and Calgary (0.5 percent) But because of a provision that teams can move up 10 spots at most in the lottery If Columbus does win the first lottery draw so there are two chances for the Blue Jackets to win and move up 10 spots Columbus has a 4.2 percent chance to earn the No 13 and a 5.1 percent chance of falling to 14th and minuscule chances the Jackets end up with picks Nos The Jackets also hold Minnesota’s first-round pick in the draft acquiring the selection in November as part of the trade that sent defenseman David Jiricek to the Wild Minnesota lost in the opening round of the playoffs Columbus has moved up in the draft lottery just once doing so in 2016 when the team had the fourth-best odds and moved up to the No which it used to select center Pierre-Luc Dubois Having missed the playoffs the previous four seasons before this year the Blue Jackets have had top-10 picks in the last four drafts the team stayed in the fifth spot and selected Kent Johnson; in 2022 the Jackets had Chicago’s first-round selection (sixth overall) and their own (12th overall) and picked Jiricek and Denton Mateychuk; in 2023 the Jackets fell from second to third and drafted Adam Fantilli; and in 2024 the team stayed at fourth overall and chose Cayden Lindstrom Here’s a quick look at some of the top players in the draft per NHL Central Scouting’s final rankings North American Skaters International Skaters Another player to keep an eye on: left-shot defenseman Sascha Boumedienne an Ohio AAA Blue Jackets product who recently notched 14 points in seven games -- a tournament record for defensemen -- for Sweden at the IIHF World U-18 Championship Boumedienne is the son of former CBJ scout and assistant coach Josef Boumedienne and was a freshman at Boston University this season notching 3-10-13 in 40 games for a Terriers team that made the Frozen Four “Sweet Dreams and the Holy Grail: Honkai: Star Rail × Fate/stay night [Unlimited Blade Works] Collaboration” will officially launch on July 11 Starting from July 11 at 12:00 (server time) Trailblazers can use Star Rail Special Passes to participate in the collaboration event and obtain the limited 5-star collaboration characters Saber (Destruction: Wind) and Archer (The Hunt: Quantum) This collaboration warp will be available over a long period of time *The cumulative warp count for this collaboration warp is calculated independently of other warp types (e.g Please stay tuned for future official announcements for more details about the warp details and warp event rules I will give it my all to bring you victory.” The solitary Heroic Spirit traverses the long night of fate The banner of the round table remains unfurled in a dream the knight-king of Camelot has yet to reach that ever distant utopia she has heeded the call for this most unique iteration of the Holy Grail War With the Sword in the Stone offering its choice once more how shall she shatter the illusions of the past “The wishes I did not fulfil will end here.” so let’s keep things civil—if we can.” Despair plays in cycles from past and future Countless grand ideals were incinerated before that red and sacred cloth do not let this smear of ashes fool you… Should someone create a phantasmal sweet dream under the guise of false ideals facing down the hypocrites of the world till the very end he always remains justice’s steadfast companion After July 11 at 12:00 (server time) and until Version 3.6 ends Trailblazers can log in to the game to claim the limited 5-star collaboration character *Please refer to the follow-up announcements for detailed event rules and summon historical celebrities as Servants – the first Penaconian Holy Grail War is about to begin the “Fate/stay night” event begins and try different classes to win strategic battles Reproduction in whole or in part in any form or medium without acknowledgment of Gematsu is prohibited Use of this site is governed by all applicable laws Website by 44 Bytes Please enable JS and disable any ad blocker Grand Rapids — A Kent County jury deciding the fate of an ex-Grand Rapids police officer who fatally shot a Black motorist after a 2022 traffic stop will resume deliberations Tuesday morning after deliberating for roughly four hours Monday. Christopher Schurr is on trial for second-degree murder in the death of 26-year-old Patrick Lyoya. Schurr pulled Lyoya, a Congolese immigrant, over for having a license plate that didn’t match the car he was driving. Schurr attempted to place Lyoya under arrest, but the motorist ran away and Schurr chased him. Minutes later, the two were wrestling over Schurr's Taser before Schurr shot Lyoya in the back of the head as he was face down on the ground. Schurr took the stand on Friday, testifying that he feared for his own life as he and Lyoya wrestled over Schurr's Taser. "I believed that if I hadn’t of done it at that time … then I wasn’t gonna go home,” Schurr said, wiping away tears. Prosecutors, meanwhile, put experts on the stand who testified that Schurr made several tactical errors and the use of force wasn't justified. The shooting has sparked national attention while highlighting a history of tense relations between the city of Grand Rapids, its police department and the city’s Black residents. The city of Grand Rapids fired Schurr in June 2022, and the officer didn't fight the action. Lewis “Von” Kliem of Force Science, a use-of-force expert consultant, testified on Friday and Monday that he felt Schurr acted appropriately and reasonably when he shot Lyoya, contradicting expert witnesses who testified for the prosecution early last week that the officer made a series of tactical decisions that led to the unnecessary death of Lyoya. Schurr, who testified Friday, described in detail his struggle with Lyoya after he ran from the officer and how he feared Lyoya would injure him as the two wrestled on the ground for control of his Taser moments before Schurr fired a single shot into the back of Lyoya's head. On cross examination, Schurr admitted that his recollection of the incident relied, at least in part, on reviewing the video captured on his police cruiser dash cam and body cam, as well as cellphone footage taken by Lyoya’s front seat passenger, Aime Tuyishme. “I used the video to direct the statement,” Schurr testified Friday. “There are definitely things I note more now.” “So you’re basing some of the stuff on the video and don’t remember all of it,” said Kent County Prosecutor Chris Becker. After Schurr’s legal team rested their case Friday morning, Becker recalled Michigan State Police Det. Sgt. Aaron Tubergen, the lead investigator on the case. After briefly discussing the points of contact Tubergen had with Schurr following the shooting, Becker had Schurr’s written documentation of the incident entered into evidence, both of which describe Lyoya’s actions that day as he “was trying to get away.” During his closing arguments, Becker said he wasn't going to paint Lyoya as a saint but he "didn't deserve to die." “What it boils down to is just a few elements," he said. "Patrick died from a gunshot wound to the head. I’m not gonna sit here and argue Patrick was a saint. He was drunk driving. He was driving without a driver's license. Those are not executable offenses. He didn’t deserve to die." He said Lyoya did some "dumb, bad things," as did Schurr. “There are critical mistakes that occurred — that a reasonable officer wouldn’t make these decisions,” he said. Becker told the jury that they aren’t supposed to evaluate the case in terms of who is a better person, but on the totality of the circumstances. “You’ve got to base your decision on the facts of the case. Not well, (Schurr’s) a hometown boy who wanted to do good and (Lyoya’s) a bad guy who was drunk driving,” Becker said. “It was reasonable to shoot Patrick because he had the Taser and Officer Schurr was exhausted — that was the excuse,” Becker said. “He didn’t point it. … (Schurr) thought he would point it. He simply had the Taser. He was exhausted and alone. Why? Why were you in that situation? “You can’t take a life without a darned-good reason,” Becker said. “And that’s not enough. Pain is not a reason to use deadly force. … How does a reasonable officer in this situation say: I’m gonna die?” Defense attorney Matt Borgula said the prosecution failed to meet its burden of proving the case beyond a reasonable doubt. “The prosecutor is trying to make this case something it’s not,” Borgula said. “You’re not here to reasonably judge if he had a reason to chase (Lyoya). You’re not here to judge GRPD policy. You have to find that beyond a reasonable doubt, Officer Schurr had a legitimate fear of great bodily harm or death.” Borgula said the Taser is a critical component that factored into Schurr’s decisions that day. “Patrick Lyoya grabbed it and never let go … and decides he’s not giving it back. And then the fight is on,” Borgula said. “They both want the Taser. And Officer Schurr has a right to it and Patrick Lyoya did not.” Borgula said Schurr was simply trying to do his job. “Christopher Schurr was at work and he was faced with the toughest decision of his life in half a second,” Borgula said. “Was it reasonable in that split second that an officer could be in fear of the Taser? He has no idea what Patrick Lyoya is going to do with it, but he doesn’t have time to figure it out. He has half a second to make up his mind.” Judge gives the jury optionsKent County Circuit Court Judge Christina Mims told jurors they could consider the second-degree murder charge brought in the trial, but also said a charge of voluntary manslaughter could be considered. In Michigan, second-degree murder differs from voluntary manslaughter primarily in the element of malice, the intent to kill or cause great bodily harm. Second-degree murder requires malice or reckless disregard for human life, while voluntary manslaughter involves an intentional killing, but the killing occurs in a state of emotional excitement caused by serious provocation. Involuntary manslaughter carries a penalty of up to 15 years in prison. Second-degree murder is a potential life sentence. “As jurors, you must decide what the facts of this case are, to apply the law as I give it to you and to decide the case,” Mims said. “You must decide what was in the defendant’s mind at the time of the killing.” When explaining the possible outcomes, Mims said jurors may find one of three possible verdicts and must be unanimous in their finding: guilty of second-degree murder, guilty of voluntary manslaughter or not guilty. “The crime of murder can be reduced to voluntary manslaughter if it was a crime of passion … and if the defendant didn’t have a reasonable amount of time to calm down. The law doesn’t say how much time is needed — that is for you to decide.” The jury will resume deliberations at 8:40 a.m. Tuesday. with analysts ready to react swiftly as earnings drop Ford’s (F) first-quarter earnings report is due Monday evening, and everyone is focusing on one number — $6 billion. That’s the midpoint threshold investors are watching for in Ford’s full-year profit guidance, as tariff drama under Trump’s administration casts a long shadow over the auto sector It’s been a rocky start to 2025 for most carmakers, but Ford might be sitting in the best seat in the house. While imported cars face a punishing 25% tariff, Ford only imports about 20% of the vehicles it sells in the U.S Ford’s tariff hit could land under $1 billion — far less than the estimated $2–$5 billion in damage facing rivals like GM and Stellantis The tariff sting eased slightly last week. President Trump tweaked the policy so tariffs on imported vehicle parts now come with a 15% offset in year one Parts still cross borders several times before assembly but this reprieve gives Ford much-needed breathing room Wall Street expects Ford to post a breakeven quarter on $38 billion in sales — down from $2.8 billion in profit and 49 cents EPS a year ago But what really matters is forward guidance Ford’s prior outlook called for $7–$8.5 billion in 2025 operating profit options markets imply a 7% move post-earnings Ford shares have dropped after three of the last four reports Ford extended its employee-pricing-for-all program through July 6 “The campaign has resonated deeply with the public,” said Rob Kaffl It’s already delivered double-digit sales growth earnings call will answer the billion-dollar question they might just shift into a higher gear — tariffs or not Ford’s current Wall Street sentiment leans cautious. According to TipRanks, just 3 out of 16 analysts rate the stock a “Buy,” while the majority (11) say “Hold” and 2 recommend “Sell.” The average 12-month F price target stands at $9.50 — nearly 7% below Ford’s latest close of $10.21 — with estimates ranging from a low of $7 to a high of $14 But that stance could easily flip after today’s results Analysts are laser-focused on one key figure: whether Ford’s full-year operating profit forecast stays above $6 billion A drop below that level could fuel further downgrades and drag the average target even lower it could shift sentiment upward and breathe new life into the stock’s outlook the Street won’t stay on the fence for long Expect ratings and price targets to react fast once Ford reveals whether it’s steering toward a $6 billion floor — or falling through it See more F analyst ratings Disclaimer & Disclosure Report an Issue Ford’s (F) first-quarter earnings report is due Monday evening, and everyone is focusing on one number — $6 billion. That’s the midpoint threshold investors are watching for in Ford’s full-year profit guidance, as tariff drama under Trump’s administration casts a long shadow over the auto sector It’s been a rocky start to 2025 for most carmakers, but Ford might be sitting in the best seat in the house. While imported cars face a punishing 25% tariff, Ford only imports about 20% of the vehicles it sells in the U.S The tariff sting eased slightly last week. President Trump tweaked the policy so tariffs on imported vehicle parts now come with a 15% offset in year one Ford’s current Wall Street sentiment leans cautious. According to TipRanks, just 3 out of 16 analysts rate the stock a “Buy,” while the majority (11) say “Hold” and 2 recommend “Sell.” The average 12-month F price target stands at $9.50 — nearly 7% below Ford’s latest close of $10.21 — with estimates ranging from a low of $7 to a high of $14 See more F analyst ratings Disclaimer & Disclosure Report an Issue Ford’s entire 2025 outlook may hinge on whether it can hold the line on a critical $6 billion profit forecast The US Federal Reserve has attracted a lot of attention from cryptocurrency investors awaiting decisions that could significantly affect the Bitcoin price Amid the consolidation of the main cryptocurrency’s price around $94,000 upcoming economic events may set a new trend especially given the increasing dependence of crypto assets on macroeconomic indicators in 2025 Coface : Coface records a good start to the year with net income of €62.1m, for an RoATE of 12.7% First Quarter 2025 Shareholder Report and money- making insights straight into your inbox Helping clients determine when and how to best claim benefits is valuable Most Guaranteed Lifetime Income Benefits are fully guaranteed others not so much; does your client understand what they have Make sure you are THE ONE in your territory who can answer common consumer questions [free guide] American Equity offers competitive commissions [Check out our FREE VIDEO on why you should have E&O.] Learn this and much more from the Society of FSP's FREE 2014 Advisor Success Kit The Jefferson County Commonwealth's Attorney Office said Moises May was recommended a sentence of 35 years in prison after he was found guilty on felony charges of human trafficking kidnapping and intimidation and misdemeanor charges of harassment May will be formerly sentenced July 2 in Jefferson County Circuit Court “This was a deeply emotional case for all involved and I commend the diligent and hard work of our Special Victims Unit prosecutors in getting justice for the victim,” Commonwealth’s Attorney Gerina Whethers said “Human trafficking will never have a place in our community and this outcome sends a strong message that we will stand up against these despicable acts.” Maxwell Gosman also thanked the woman as well as local agencies who assisted in her rescue “I want to commend the bravery and resilience of the victim in this case without whom we could not have achieved justice A victory in this case will hopefully bring some meaningful closure amid very difficult circumstances,” Gosman said “I also want to commend the outstanding work of Louisville Metro Police Det whose investigative initiative was critical in ensuring that the defendant was held accountable for his horrific crimes.” More: Man accused of chaining woman to floor in Park Hill pleads not guilty LMPD officers responded to a two-story house in the 1700 block of Bolling Avenue in the Park Hill neighborhood in August 2023 after a call came in from neighbors reporting a woman screaming for help Officers discovered the first floor of the house was barricaded and that all the doors were screwed shut Ladders were reportedly required to gain access to the second floor of the home where the woman was found chained to the floor by a metal dog collar The Courier Journal does not name victims of crimes unless they choose to be identified May and the woman were arguing when May allegedly grabbed the woman and held her down on a bathroom floor "while he used a machete to cut off a majority of her hair." May then "slapped the victim around" before she was able to leave May allegedly threatened to kill the victim multiple times tying a metal dog chain around her neck and bolting her to the floor He then took her phone so she could not call for help The woman was later able to break open a window and scream for help, prompting bystanders to call the police, the citation said. LMPD, along with Louisville Fire and Rescue, responded to the call and were able to rescue the victim and treat her for minor injuries Former Courier Journal reporter Rae Johnson and producer Ray Padilla contributed Reach Marina Johnson at Marina.Johnson@courier-journal.com With a Fate-themed story written by Kinoko Nasu HoYoverse finally announced the Honkai Star Rail x Fate collaboration release date during the second HSR concert including details about which characters will join the space game's roster in an event called Sweet Dreams and the Holy Grail and it adds two new 5-star characters from the Fate series to HSR's list of playable characters a 5-star Destruction character with wind as her element is one of Fate's main characters and first debuted in 2004's Fate/Stay Night Saber will run for the usual length of time in a limited event banner The second Fate character in HSR is Archer Archer is a 5-star Hunt character with quantum as his element and anyone who logs into Honkai Star Rail during Sweet Dreams and the Holy Grail will get him for free HoYoverse said the free Archer giveaway will last through the end of Honkai Star Rail 3.6 Based on the game's current update calendar Assuming the free Archer event is like the time HoYoverse gave Dr Ratio away you'll probably only need to be at the story's beginning at the point where you unlock the warp function Saber will have "exciting" interactions with the Trailblaze crew during the event's associated story missions Fate writer Kinoko Nasu penned the crossover event's story and artist Takashi Takeuchi created the Honkai Star Rail versions of Archer and Saber HoYoverse also teased a new Honkai game during the concert though had no further information to share at the time © 2025 VG247 a brand of IGN Entertainment, Inc. 18 Mansell Street Level 3, London, E1 8AA, United Kingdom.All rights reserved. No part of this website or its content may be reproduced without the copyright owner's permission. VG247 is a registered trademark of Gamer Network Limited, an affiliate of IGN Entertainment, Inc. Houston Rockets fans are heartbroken. Their team had a tremendous 2024-25 season Defeat came at the hands of the Golden State Warriors The Rockets surpassed expectations by securing the second seed in the Western Conference A first-round defeat to a more experienced team was always an acceptable outcome Had James Harden and his Clippers vanquished the Rockets sleep would not have been so elusive last night we're left processing our collective trauma Rockets fans today could be cast in One Flew Over The Cuckoo's Nest Green can't hit one too...Curry again...Nooooooo" it's time to think about the offseason The Rockets got largely positive contributions from their young core Alperen Sengun's efficiency left much to be desired He also shouldered a disproportionate amount of responsibility but his willingness to try should be commended He struggled to generate offense in the halfcourt for the first few games Once he realized that the paint was his domain and nobody could take it from him The Rockets should be encouraged by the sophomore's first postseason appearance but he established himself as a valuable piece He made some head-scratching plays throughout this series but he also asserted his will often enough to inspire hope Green scored 13.3 points per game in the Rockets' series with the Warriors That includes a 38-point outburst in Game 2 One transcendent performance lost in a forest of sorrow Just when you've concluded that it's time to leave he ropes you back in with a thoughtful gift It's time for the Rockets to put his stuff in a box They'll suggest that Green is a downhill guard on a team with the NBA's worst spacing Sengun and Thompson feel like the two players who don't complement Green in the starting lineup and 5.3 assists per game with a Box Plus/Minus (BPM) of 4.7 and a True Shooting % (TS%) of 49.1% and 2.9 assists with a BPM of -1.5 and a 48.2 TS% You are the Houston Rockets' General Manager (congratulations!) The owner has informed you that he doesn't believe in Player A and Player B as a pairing and given you a mandate to trade one this summer Why invest in the one that hasn't produced It is possible that he would be more productive in a different system but every advanced metric suggests that he impacts winning even when the shot isn't falling The same metrics suggest almost universally that the Rockets are better when Green is on the bench Building an NBA team doesn't require a lofty education. You identify what's working and curate it, and cull whatever isn't. Surrounding Sengun and Thompson with shooters should result in a strong team. Forming a Big 3 with that duo and a star player with substantial three-point gravity should work Clinging to Green's potential despite a mountain of empirical evidence that he's not reaching it should not: He'll only break the Rockets' hearts again © 2025 Minute Media - All Rights Reserved The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER Will the Rockets become the 14th team in NBA history to win a best-of-seven series after falling into a 3-1 hole Or will we be speaking about the path forward for them this offseason come Monday morning the ripple effects of Houston's fate will be felt not just across the organization The overarching consolidation exercise is a fair one Never mind how you feel about the Rockets having enough offensive upside over the long term They can't afford to keep this core together forever it's that NBA windows open and close fast even when it seems like they'll last for extended pockets to the Rockets operating with a semblance of urgency over the offseason banked on them getting bounced in the first round And it seemed borderline infallible when they were down 3-1 Well, they aren't anymore. And if they win a playoff series against a more veteran team, even as the higher seed, it lends credence to the wait-and-see approach espoused by general manager Rafael Stone Maybe Amen Thompson has another level on offense Or perhaps they dust off Reed Sheppard next year to level up Stone for the time being will not place limits on Houston's players Beating the Warriors to some extent validates that approach The consolidation route will remain appealing particularly to those evaluating the team from a 10,000-foot view But the difference between going all-in for Giannis or Devin Booker surely can't be the outcome of one game...right Losing no doubt gives the Rockets more to reflect upon Their hands will also be somewhat tied by the trade market They can't deal for Giannis or Booker if he's not available Houston has create-your-own-trade-market assets It is not constrained by the same limitations as others But it does have to decide which of its prospects are core players and which they will strive to protect at all costs as part of any consolidation move not do—on the trade market will have seismic ripple effects across the rest of the league Beyond the extension eligibility of Eason and Smith the Rockets have two key could-be free agents Steven Adams is headed to unrestricted free agency while Fred VanVleet has a $44.9 million team option Winning or losing against the Warriors may not determine their fates perhaps they're more comfortable declining VanVleet's team option and re-signing him for the longer haul at a smaller annual number Traveling this path lets them duck the tax while also re-signing Adams and preserving its punishing dual- and triple-big lineups Or they could see more value in picking up VanVleet's team option preferring to use him as a stopgap through next season or an expiring-contract trade chip in the pursuit of bigger name players Whatever they do with Adams and VanVleet must be viewed through the lens of the longer-term payroll Can they retain both at multiyear numbers that jibe with what they'll (possibly) be paying all of Sengun And if Houston gets peeved by any of their impending future commitments does it open the door for suitors to swoop him and acquire the needs-to-be or soon-to-be paid the Rockets will have tough calls to make over the offseason But advancing makes the process much easier allowing Houston to operate from a position of strength having shown that everyone already in place can make meaningful noise without a major addition or overhaul at least ever so slightly increase the urge to act—that natural impulse to second-guess your path and process a matter of merely giving the roster time and space to figure it out from within Or will the Rockets require significant talent infusion from outside the organization Game 7 will go a long way towards figuring that out Dan Favale is a Senior NBA Contributor for FanSided and National NBA Writer for Bleacher Report. Follow him on Bluesky (@danfavale), and subscribe to the Hardwood Knocks podcast, co-hosted by Bleacher Report's Grant Hughes Now only down 3-2 in their first-round series against the Golden State Warriors, the Houston Rockets are still playing from behind. They won big in Game 5, yet there were still some downsides to the performance. Most notably, Jalen Green struggled once again as he continues to have a rough playoff debut Green’s shooting splits have been brutal through the first five games of the series and the Rockets need him to be at the top of his game If they want to score enough points to truly compete for a championship he’s a crucial piece of their offensive puzzle the play of Alperen Sengun has been overshadowed Sengun is also in the midst of his playoff debut and nine assists while shooting 6-of-9 from the floor He also added two steals and two blocks to his tallies Through the first five games of the series and 5.2 assists while shooting 47.7% from the field and 40.0% from deep (on 1.0 three-point attempts per game) It’s easier to envision a guy like Green to be the engine of a high-level playoff team wings and guards have led teams to title runs for ages But Sengun is a center—and a very unique one at that Nikola Jokic is the best comparison for a skilled big man leading a team to a title but he’s one of the best players of all time But just because Green is struggling doesn’t mean Rockets fans should lose hope of their team’s offense moving into the future Sengun has stared his playoff debut in the face and tackled it head-on He’s proven perfectly capable of being a top guy on a quality team in the regular season Leading a team on a deep playoff run takes a different caliber of player and considering this is his first-ever chance to prove himself Sengun looks like he could be on a solid path to getting there Green’s struggles shouldn’t distract Rockets fans from that positive—Sengun can hold up in the postseason The Houston Rockets cannot escape blockbuster trade rumors That's what happens when you have a surplus of assets The Rockets have an excessive number of future first-round picks They have more exciting young players than they'll be able to pay Those who connect the dots can only infer that they might look to consolidate assets for a superstar It doesn't help that the Rockets don't have a clear-cut franchise player Alperen Sengun has been outstanding in the playoffs but you couldn't say that his top-10 player status is a foregone conclusion we're looking at a young team with surplus assets and no franchise player The Rockets have to make a blockbuster trade "We're not in the business of predetermining ceilings for our players." In a recent interview, Stone went on to say that the Rockets would have a "very high bar" for acquiring a superstar it's not worth blowing up this roster unless it's an opportunity the Rockets can't pass on They want the team to make a big move as soon as possible They've grown attached to this young core and want to see the rebuild through and happen to have differing views on what that would be Some have suggested that the league is trending away from top-heavy models There's speculation that the NBA is morphing into a "weak link" league rather than a "strong link" league and simply having the best player in a playoff series doesn't seem to count as much as it used to That's true - but you'll still need a superstar to win a title It may not be necessary to have a certified MVP candidate but you'll always need a top 20ish player at a bare minimum So, it does make sense to stick with this group for the time being. If the Rockets stagnate, they'll have the assets to acquire a superstar. For now, the roster is too young and too successful for fans to get too thirsty over aging stars who help their short-term desires at the expense of the team's long-term goals The Houston Rockets put up a tremendous fight The Rockets looked remarkably poised throughout their first-round series with the Warriors This was the same veteran dynasty that's been crushing Rockets fans for a decade They ended Houston's season with a 103-89 win Although their north star didn't lead the way in the first half Steph Curry was hardly even impacting the game It was Buddy Hield burying Houston's season He had an incredible 22 points on 8/9 shooting from the field and 6/7 shooting from distance in the first half Dillon Brooks' defensive strategy of giving Hield space only to aggressively close out consistently backfired Seasoned Rockets fans knew that meant he was due for an explosion that's impossible" threes over the outstretched arm of Tari Eason he hit a trick layup that would make a Harlem Globetrotter blush but with contributions from their role players included that was enough to lift the Warriors to a win Amen Thompson was the Rockets' best player for a second consecutive game He was aggressive in looking for his shot all night Thompson exited this game with a leg cramp and had the heart to return The big man finished with 23 points on 9/23 shooting The Rockets would like to see a better shooting percentage and they had their best stretch with Sengun on the bench they should be pleased that Sengun didn't shrink under the bright lights That's more than they can say for Jalen Green He had 8 points. It's been a theme of this series. Green has struggled mightily to make anything happen. The Rockets must evaluate his future with the team in the offseason Having a reliable creator in the backcourt would have been tremendously helpful the team will watch the playoffs unfold from a distance The 2024-25 Rockets will go down in history as a team that surpassed expectations It would be nice if they could beat the Warriors Houston Rockets fans are heartbroken. Building an NBA team doesn't require a lofty education. You identify what's working and curate it, and cull whatever isn't. Surrounding Sengun and Thompson with shooters should result in a strong team. Forming a Big 3 with that duo and a star player with substantial three-point gravity should work signing Australian all rounder Mitchell Owen Owen’s immediate availability remains uncertain due to his ongoing commitments with Peshawar Zalmi in the Pakistan Super League (PSL) highlighting the complexities of modern cricket’s franchise driven calendar Glenn Maxwell’s IPL campaign ended prematurely after he fractured a finger during the tournament registering single digit scores in five of his six innings His absence left a void in PBKS’s middle order prompting the franchise to turn to Mitchell Owen a rising talent fresh off a breakout season in the Big Bash League (BBL) emerged as one of the most exciting young players in T20 cricket after a stellar BBL season He finished as the tournament’s leading run scorer with 452 runs at a strike rate of 203.60 including a match winning 108 off 42 balls in the final to guide Hobart Hurricanes to the title.His bold batting and handy medium pace bowling make him a valuable asset fitting PBKS’s high-tempo approach this season is complicated by his current stint with Peshawar Zalmi in the PSL with their final group-stage match scheduled for May 9 Owen’s PSL commitments could extend until the final on May 18 just two days before the IPL playoffs begin This overlap means Owen may miss PBKS’s remaining group stage matches joining only if the team advances to the knockout stages are banking on his potential impact in the playoffs who also serves as Hobart Hurricanes’ head of strategy Ponting’s endorsement played a key role in the franchise’s decision to sign the young all rounder Owen’s recent performances in the SA20 and PSL though modest in the latter with an average of 16.83 in six innings have further cemented his reputation as a dynamic T20 player Owen’s entry into the PSL itself came under unusual circumstances He was signed by Peshawar Zalmi as a replacement for Corbin Bosch who withdrew from the tournament to join Mumbai Indians (MI) as an injury replacement for Lizaad Williams Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Sports Illustrated or its affiliates Sony has released the top downloads for April 2025 the top downloads only include purchases from the PlayStation Store but nevertheless give a strong indication of the monthly sales success of VR titles as most PSVR 2 games are only available as digital downloads and not at retail and hybrid titles that can be played without a headset Below are the top downloads for April 2025 divided into North America and EU regions: The VR time travel adventure Wanderer: The Fragments of Fate took the top spot in North America and Europe The title had previously been delayed several times so PSVR 2 players were clearly excited to finally be able to play it On Playstation VR 2, Wanderer: The Fragments of Fate is one of the best-looking VR games it received much criticism for its rudimentary combat system The studio has vowed to do better and has released a roadmap of patches planned through July PS5 Pro support with exclusive visual enhancements new DLC content and ongoing bug fixes are also planned Note: Links to online stores in articles can be so-called affiliate links. If you buy through this link, MIXED receives a commission from the provider. For you the price does not change. it's time to start looking forward to the NBA Draft as a way to replace Kyrie Irving's production while he rehabs his ACL tear While the Dallas Mavericks organization is still trying to figure out what hit them following the trade of Luka Doncic There's been talk about the Mavericks replacing Irving for the first few months of the season to make up for the team's lack of ball handling. The Mavs might get a gift if they land Egor Demin from BYU but with Bill Duffy being the agent of Demin and Luka Doncic there might be some beef between Duffy and Nico Harrison moving forward and connections are everything in the NBA today Connections are how Anthony Davis landed in Dallas; Harrison has been good friends with Davis for years and it's easy to see why Harrison chose Davis as his next big cash cow the connections might end up costing Harrison altogether with one Western Conference executive saying that Harrison will never see the light at the end of the tunnel once his days in Dallas are over With Mark Cuban handing the keys over to Patrick Dumont, he never knew exactly what Dumont was going to get himself into. Under his first year as Mavs Governor, he has seen the trade of his generational superstar, and the fanbase in a revolt with fans calling for Harrison's job. Cuban even tried to save Doncic but it was too late; the unfathomable trade had already gone through As ESPN's Tim MacMahon says on "The Right Time with Bomani Jones," MacMahon states that one source he spoke to absolutely obliterated Harrison's tenure in the NBA (39:31 mark) saying Harrison might never see the light of day with any other team again "I was talking to somebody who's in an ownership group of another Western Conference recently and they basically said 'I hate to say it but this is going to be his legacy,'" MacMahon said like he's never going to work in the NBA again." This goes hand and hand with other executives around the league talking about how much more the Mavs could've gotten for Doncic with one person saying they would've given everything for Doncic Other executives were furious about Harrison only speaking to Rob Pelinka and not giving another team a chance to bid for the Slovenian superstar This was something Mavs fans had always realized as calls to "fire Nico" were on display during Doncic's first time back at American Airlines Center MacMahon added that it's the players that sell tickets and it's apparent that the noise from fans is getting to those executives © 2025 Powered by Minute Media - All Rights Reserved ","https://fansided.com/",{"alt":"63","src":"64","url":"65"},{"type":"62","value":"66"},"link","Powered by Minute Media","https://www.minutemedia.com/",{"text":"69","url":"6a"},{"type":"68","value":"6b"},"All Rights Reserved Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Minute Media or its affiliates and related brands Jared loves specializing in what The Smoking Cuban is all about He's been involved in the sports media realm since 2017 He has lived in the DFW area for much of his life following all Dallas professional sports very closely He's also covered sports at Oklahoma State and currently covers Texas A&M sports He has a Bachelor of Arts in Sports Media from Oklahoma State He's done play-by-play radio broadcasting in North Central Oklahoma and currently does play-by-play radio broadcasting for high school football in North Texas Jared loves watching sports and spending time with family and friends There's been talk about the Mavericks replacing Irving for the first few months of the season to make up for the team's lack of ball handling. The Mavs might get a gift if they land Egor Demin from BYU With Mark Cuban handing the keys over to Patrick Dumont, he never knew exactly what Dumont was going to get himself into. Under his first year as Mavs Governor, he has seen the trade of his generational superstar, and the fanbase in a revolt with fans calling for Harrison's job. Cuban even tried to save Doncic As ESPN's Tim MacMahon says on "The Right Time with Bomani Jones," MacMahon states that one source he spoke to absolutely obliterated Harrison's tenure in the NBA (39:31 mark) This was something Mavs fans had always realized as calls to "fire Nico" were on display during Doncic's first time back at American Airlines Center setting the stage for a faceoff in the Senate where Democrats say GOP leaders would have to defy long-standing protocol to get the measures passed The votes called into question California’s waiver from the Clean Air Act of 1970 an authority that has allowed the state to set stricter pollution guidelines and empowered its leaders to set an alternative standard on car emissions to those of the federal government For decades, automakers have bent their car production lines to meet California mileage standards, in part due to the size of the California market and in part because the industry has found it a safer bet — with changes in power so common in Washington — to be more stringent on fuel efficiency standards than the alternative. Today, more than a dozen states follow California’s standards, including New York, Colorado, Massachusetts, Washington and Oregon. Politics President Trump’s administration, with help from the Republican-led Congress, may pull the state’s ability to set its own fuel-efficiency rules. But since President Trump took office, the Environmental Protection Agency has questioned whether that authority amounts to a technical “rule” that allows for the Senate to disapprove of the waiver with a simple majority vote, under the Congressional Review Act. Trump campaigned on a promise to reverse government programs promoting the sale of electric vehicles — often derided by critics as “EV mandates” — advocated by then-President Biden and the California government, which aims to phase out the sale of new gasoline-only vehicles by 2035 with its latest program, Advanced Clean Cars II. Over the last two months, two independent offices — the Senate parliamentarian and the Government Accountability Office — have found that California’s waiver authority is not subject to review under the act. California’s waiver, the GAO said, is “not a rule” under the law, noting that the matter had been reviewed multiple times over the last 60 years. The “EPA’s recent submission is inconsistent with this caselaw,” the office found. But those rulings were not enough to stop votes from proceeding in the House. It now falls to Senate Republican leadership, under Majority Leader John Thune (R-S.D.), to decide how to proceed — and Thune has “made no commitments” either way, Sen. Alex Padilla (D-Calif.) said Thursday in an interview with The Times. “I hope for the best, but I prepare for the worst,” Padilla said. “In my heart of hearts I think that he wouldn’t. He has made statements about respecting the parliamentarian’s determinations. “But given the start of the year that we’ve had, and how the Republican Congress, including the Republican majority in the Senate, are just sort of caving and giving Donald Trump everything he’s asked for — we have to prepare for anything,” he continued. “I wouldn’t put it past him, I guess I should say.” California Gov. Gavin Newsom, a Democrat, described the House vote as a “lawless” act of defiance against the Senate parliamentarian’s findings. “Our vehicles program helps clean the air for all Californians, and we’ll continue defending it,” Newsom said. The office of state Atty. Gen. Rob Bonta said he was “monitoring the situation closely,” suggesting litigation may follow if Senate Republicans proceed with a vote. “The Congressional Review Act was designed to provide a mechanism for congressional oversight of new rules by federal agencies — not for partisan attacks on duly-adopted state laws,” Bonta said. “Not only would the misuse of the CRA undermine the integrity of our democratic process, but it would also be unlawful.” An EPA spokesperson declined to comment on the process to come in the Senate, but noted that Shelley Moore Capito, a Republican senator from West Virginia, put out a statement in support of the House measures shortly after their votes. California California would be the first U.S. state to mandate 100% zero-emission vehicles, though 15 countries have committed to phasing out gas-powered cars. Climate activists are expressing concern over the activity on Capitol Hill, with the Center for Biological Diversity’s Climate Law Institute characterizing the Republican actions as a “sneaky and illegal” procedural trick “to try and kill California’s clean air protections.” Others that have long advocated against California’s influence over fuel efficiency standards hailed the votes on Thursday. In a statement, American Fuel & Petrochemical Manufacturers President and Chief Executive Chet Thompson and American Petroleum Institute President and Chief Executive Mike Sommers said that action in the House was “a huge win for U.S. consumers,” asserting that states are far from achieving their target sales numbers under Advanced Clean Cars II. “We are one step closer to restoring consumers’ ability to choose the cars that best meet their needs,” the executives said. “California’s unlawful ban should never have been authorized, and Governor Newsom should never have been allowed to seize this much control over the American vehicle market.” “We urge the Senate to act swiftly,” they added. California Sen. Adam Schiff’s office said he would urge others in the Senate to adhere to the GAO’s findings, noting that Thune previously committed to following “regular order” on votes — which, traditionally, has meant heeding the parliamentarian and GAO offices. “Republicans have themselves admitted that the Congressional Review Act is not a tool at their disposal to ignore the law and overturn precedent, as has the Senate Parliamentarian,” Schiff said in a statement. “We will fight this latest attack on California’s power to protect its own residents,” he added, “and I will urge my colleagues in the Senate to recognize the severe implications of proceeding with this violation of state’s rights, as well as the dangerous precedent it would set by flouting the unanimous opinion of Congress’ trusted arbiters.” Subscribe for unlimited access Site Map You can preorder the $100 TMNT: Splintered Fate Collector's Edition to get a comic book, RPG dice, art book, foil trading cards, and more. TMNT: Splintered Fate originally released as an Apple Arcade exclusive in May 2023 before being ported to PC and Switch last summer PlayStation and Xbox editions will be available digitally on May 20 and June 24 The Deluxe and Collector's Editions will bring Splintered Fate to physical format for the first time the Deluxe Edition includes the base game plus a bunch of extras you’ll get a physical pack of 10 foil trading cards featuring familiar faces like Leonardo It also comes bundled with the Casey Jones DLC that adds the hockey-stick-wielding vigilante as a playable character The Deluxe Edition will get you access to a future Considering this version of the game is only $40 (compared to $30 for the base game) that’s a pretty impressive list of additional goodies Splintered Fate's Pipin' Hot Collector's Edition includes a bunch of additional extras this is one of the most jam-packed collector's editions we've seen in quite some time The Pipin' Hot Collector's Edition is packaged in a slipcased pizza box The Collector's Edition is available to preorder on PS5 Our Teenage Mutant Ninja Turtles: Splintered Fate review gave the side-scrolling a brawler a solid 7/10 praising it for fast roguelite action and fun cooperative gameplay modes and the new physical release will enjoy all those improvements right out of the box Got a news tip or want to contact us directly? Email news@gamespot.com ESC Log in to comment "data-img-src" : imgSrc } = buylink %> />><%= itemTitle %> Get the latest gaming news, reviews, and deals sent to your inbox Monday to Friday. Joshua Farmer was sentenced to 80 years in prison James Harden was a no-call-no-show in the LA Clippers' 120-101 loss to the Denver Nuggets at Ball Arena He played 35 minutes but would have been as helpful if he had not laced up his kicks and remained in street clothes Furthermore, if there was a metric below zero to measure how aggressive Harden was in game seven, that is where he ranked. He was playing more like a true point guard, and this is the side of the former MVP that has built a decade-long narrative Harden was checked out by head coach Tyronn Lue down 33 in the fourth and this was the last time fans would see him shooting two-for-eight from the floor with a +/- of -29 Scoring single digits in an elimination game, at Ball Arena of all places, is the worst thing a superstar could do, yet this was the lowest point and poorest efficiency of all the game sevens Harden has been deployed into This leads the front office to determine whether to increase the former MVP's salary next season knowing he will inevitably drown in the playoff waters Although James Harden is receiving a team-friendly annual dollar of $35 million He and his representatives will decide whether to repeat another year with Kawhi Leonard and earn an extension or opt out and join his fifth different team in six seasons Moreover, the LA Clippers were sent to Cancun a month too soon and Harden will be expecting Steve Ballmer to reward him for his timelessness but it all comes down to how Ballmer gauges the product of the playoffs and 5.8 rebounds and earning an All-Star selection and possible All-NBA honor But Ballmer must consider how much more he can realistically offer the three-time scoring champion before enough is enough Paying an aging superstar a generous check is never smart and the Clippers' best lesson is to do their homework on Paul George This implies that Harden may have sealed his fate in Inglewood ","https://fansided.com/",{"alt":"61","src":"62","url":"63"},{"type":"60","value":"64"},"link","Minute Media","https://www.minutemedia.com/",{"text":"67","url":"68"},{"type":"66","value":"69"},"All Rights Reserved He began writing for Clipperholics in April 2022 before being elevated to a Site Expert role in October 2023 Iliyan has written for FanSided’s ReignOfTroy he has also gained experience through internships with Sports Radio America and Fantom Sports Industries Furthermore, if there was a metric below zero to measure how aggressive Harden was in game seven, that is where he ranked. He was playing more like a true point guard, and this is the side of the former MVP that has built a decade-long narrative Scoring single digits in an elimination game, at Ball Arena of all places, is the worst thing a superstar could do, yet this was the lowest point and poorest efficiency of all the game sevens Harden has been deployed into Moreover, the LA Clippers were sent to Cancun a month too soon Paying an aging superstar a generous check is never smart Here is an overview of the game, via its Steam page: Unleash the Turtles in a roguelike quest to rescue Splinter from the Foot Clan! Master ninja skills, unite in bodacious cooperative gameplay When Splinter is kidnapped by Shredder, mysterious portals simultaneously appear across NYC. With April and Metalhead analyzing recovered artifacts for clues the Turtles battle to recover their father from the clutches of the Foot Clan as the gang gets ever closer to Splinter’s otherworldly location an even greater threat lingers in the shadows… In Teenage Mutant Ninja Turtles: Splintered Fate roguelike action where no two runs are the same and team up with friends for bodacious cooperative gameplay and prepare to face off against formidable enemies With thrilling combat and endless challenges Splintered Fate promises to keep you engaged in the fight Metrics details How cells change shape is crucial for the development of tissues studying these shape changes in detail is challenging Here we present a comprehensive real-time cellular map that covers over 95% of the cells formed during Caenorhabditis elegans embryogenesis This map includes information on each cell’s identity all accessible through our user-friendly software and website Our map allows for detailed analysis of key developmental processes We show how Notch and Wnt signaling pathways along with mechanical forces from cell interactions regulate cell fate decisions and size asymmetries Our findings suggest that repeated Notch signaling drives size disparities in the large excretory cell This work sets the stage for in-depth studies of the mechanisms controlling cell fate differentiation and morphogenesis all these single-cell analyses deduce a cell state mainly dictated by molecular signatures Integration of quantitative data on these parameters with single-cell omics data is expected to significantly improve the power to draw more biologically relevant conclusions in terms of the progression of cell fate specification and differentiation a complete picture of the cellular morphology of ascidian embryos has yet to be obtained due to technical difficulties in the segmentation of late-stage embryos both the modeling-based method and CShaper were only able to produce cellular morphology for the first half of embryogenesis (i.e. due to the difficulties in modeling or segmenting membranes of the highly crowded cells at a stage beyond the 350-cell stage the expression intensity of the transgenic membrane markers becomes dimmer than in the early stage making it impractical to reconstruct the cellular morphology map beyond the 350-cell stage most embryonic cells at this stage have not completed their final round of embryonic division and have not yet differentiated to their terminal fate which prevents the study of the gene regulations that control the fate asymmetry for most embryonic cells We finally make our data accessible both locally as standalone software or online through interactive query and vivid visualization A The data processing pipeline of CMap Time-lapse 3D (4D) images of GFP-labeled cell nuclei and mCherry-labeled cell membranes are used for cell lineage tracing and morphology segmentation respectively with output of cell identity (with information on cell lineage and cell fate) The EDT-DMFNet segmentation model of cell membrane morphology is explained in detail in Fig B Top: 3D projections of a dually labeled embryo at representative developmental stages indicated above; middle: outputs of cell nucleus tracing; bottom: outputs of cell membrane segmentation Nuclei and membranes are differentially colored based on their lineal origins as indicated D Comparison of average cell volume (C) and cell surface area (D) with individual measurements from the eight C Data points represent individual cell comparisons with the average across embryos on the horizontal axis and individual embryo measurements on the vertical axis Cells present before and after the ~350-cell stage are color-coded in blue and yellow Insets show the distribution of variation coefficients (defined as the ratio of standard deviation to average) for these comparisons based on 322 and 267 unique cells before and after the ~350-cell stage respectively Source data are provided as a Source Data file which provides an invaluable resource for studying cellular behaviors for nearly all cells with defined cell lineage and identity throughout C A Visualization of cell shapes within whole embryo or within specific tissues/organs from various perspectives B–D Depiction of dynamic cell shape changes in different tissues during late embryogenesis: skin cells (hypodermis) during dorsal intercalation (B) intestine cells during intestinal twisting and elongation (C) and body-wall muscle cells during the ingression of the AB-derived body-wall muscle cell (ABprpppppaa) Developmental time and stage are shown on the left with the last time point of the four-cell stage set as the time zero E–G Quantification of cell irregularity (η) for the processes shown in (B–D) Panel (E) presents the average (solid dot) and standard deviation (solid line) of the irregularity for 9 skin cells during the developmental timeline (t) in an exemplary embryo with the last time point of the four-cell stage set as the time zero Panel (F) presents similar data for all cells during the developmental timeline (t) in an exemplary embryo Panel (G) presents the average (solid dot) and standard deviation (solid line) of cell shape irregularity (η) for the cell ABprpppppaa during the developmental timeline (t) in eight embryos the maximums and minimums are denoted by green and pink triangles respectively and the correlation coefficients for the monotonic $\eta -t$ curves are shown at the top our 550-cell-stage morphological map allows qualitative and quantitative analyses of cell deformations and migrations during morphogenesis permitting characterization of embryogenesis with exceptional spatiotemporal resolution in C consistent with the fate transformation from MS to E The results demonstrate that cell morphological dynamics indeed are correlated with their fate our publicly accessible morphological map can be utilized to address their questions of interest during development by those in the community Given the dependence between these two properties we will henceforth exclusively investigate the effect of Notch signaling on cell size asymmetry and its coupling with cell fate asymmetry Cells expressing Notch ligands are highlighted in green while those expressing receptors are in red B Plots showing the volume asymmetry ratio calculated as the net volume difference over the combined volume of anterior and posterior daughter cells from six sister-cell pairs in eight wild-type embryos and data for their sisters receiving no effective signaling (ABa and ABplpppa) or substantially weaker signaling (ABplpapa) are shown in blue The statistical significance is obtained by the one-sided Wilcoxon rank-sum test and is listed at the top C A summary graph showing the alteration in cell volume asymmetry between the daughters of six Notch target cells (red) or between the daughters of their sisters receiving no effective signaling or substantially weaker signaling (blue) D Comparison of volume (V) asymmetries of daughters of Notch target cells between wild-type (horizontal) and perturbed (vertical) embryos by RNAi against lag-1 The cell volume asymmetry between each pair of daughter cells is averaged over eight wild-type replicates and over two lag-1- replicates The statistical significance is obtained by the one-sided Wilcoxon rank-sum test and is listed on the left along with the data average (solid dot) and standard deviation (solid line) presented E Comparison of morphological changes between the Notch-responsive ABplpapp cell (middle) that receives the fourth Notch signaling and its sibling (top) which receives substantially weaker or no effective Notch signaling or the ABplpapp cell in a perturbed embryo with RNAi against lag-1 (bottom) Note the directional size asymmetry in the division of ABplpapp (middle) in contrast to its sister (top) and its perturbed state in embryos with RNAi against lag-1 (bottom) ${T}_{{{{\rm{C}}}}}$ denotes the last time point of cytokinesis these shifts were reproducibly observed in the sister-cell pairs of all eight wild-type embryos which indicates that Notch signaling not only induces fate asymmetry but also probably promotes directional change in cell size A The “H”-shaped excretory cell labeled by GFP (left) or its merge with differential interference contrast microscopy (DIC) (right) in an adult B Top: quantification of volume changes over embryogenesis for the excretory cell and all the progeny of its great-grandmother The graph shows the average cell volumes (line) and their standard deviations (shaded area) for the excretory cell and its progenitors from eight wild-type embryos in red Bottom: quantification of volume change over embryogenesis for all cells derived from AB (blue) and E (gray) with that for the excretory cell and its progenitors (red The time of ABplpapp’s birth is used as the reference point (time zero) C Comparison of morphological changes between the excretory cell’s grandmother ABplpappa with Notch signaling (middle) and its sibling with substantially weaker or no effective Notch signaling (top) or the ABplpappa cell in a perturbed embryo with RNAi against lag-1 (bottom) Note the directional size asymmetry in the division of ABplpappa (middle) in contrast to its sister (top) Cells involved in the sixth-tenth signaling events are indicated with arrows B Reconstructed 3D morphologies of contacting cell pairs engaged in the newly identified Notch signaling events during C while those expressing the receptor are in red C Comparison of morphological changes between the Notch-responsive ABprpapp cell (2nd row) that is deduced to receivs the tenth Notch signaling and its sibling (1st row) which is deduced to receive substantially weaker or no effective Notch signaling or the ABprpapp cell in a perturbed embryo by RNA against lag-1 (3rd row) or laser ablation on MSpp (4th row) Note the directional size asymmetry in the division of ABprpapp (2nd row) in contrast to its sister (1st row) or its perturbed counterpart in embryos with RNAi against lag-1 (3rd row) or laser ablation of MSpp (4th row) D Positions (illustrated with the cell nucleus positions) of the Notch-responsive cells (red) and others (semi-transparent gray) at the moments when the sixth-tenth signaling events take place This result together with those size asymmetries in wild-type and lag-1- embryos further supports that the ABprpapp cell receives Notch signaling which results in size asymmetry between its daughters’ cell size The results suggest that the fourth Notch signal alone may not be sufficient to break the lineage symmetry and the fourth interaction together with the newly identified seventh and ninth downstream interactions might be all required for proper differentiation between the relevant left and right lineages equipped with our comprehensive map of intercellular contact in combination with lineal expression of ligand and receptor of signaling pathways we were able to not only confirm the existing signaling interactions but also identify signaling interactions that are responsible for inducing size asymmetry that is often coupled with fate asymmetry A The distribution of cell volume asymmetry between daughter cells without positional bias ($\left|\frac{{V}_{{{{\rm{D}}}}1}\,-\,{V}_{{{{\rm{D}}}}2}}{{V}_{{{{\rm{D}}}}1}\,+\,{V}_{{{{\rm{D}}}}2}}\right|$) in the wild-type and pop-1- (pop-1 RNAi) embryos The cell volume asymmetry between each pair of daughter cells is averaged over eight wild-type replicates and over two pop-1- replicates Based on 257 pairs of daughter cells present in all wild-type and pop-1- embryos the statistical significance is obtained by the one-sided Wilcoxon rank-sum test and is listed in the top right corner B The negative correlation between the shift of cell volume asymmetry with (${\delta }_{{{{\rm{U}}}}-{{{\rm{C}}}}}\left[\frac{{V}_{{{{\rm{D}}}}1}\,-\,{V}_{{{{\rm{D}}}}2}}{{V}_{{{{\rm{D}}}}1}\,+\,{V}_{{{{\rm{D}}}}2}}\right]$) and without mechanical compression (${\left[\frac{{V}_{{{{\rm{D}}}}1}-{V}_{{{{\rm{D}}}}2}}{{V}_{{{{\rm{D}}}}1}+{V}_{{{{\rm{D}}}}2}}\right]}_{{{{\rm{U}}}}}$) The result of proportional fitting between ${\left[\frac{{V}_{{{{\rm{D}}}}1}-{V}_{{{{\rm{D}}}}2}}{{V}_{{{{\rm{D}}}}1}+{V}_{{{{\rm{D}}}}2}}\right]}_{{{{\rm{U}}}}}$ and ${\delta }_{{{{\rm{U}}}}-{{{\rm{C}}}}}\left[\frac{{V}_{{{{\rm{D}}}}1}\,-\,{V}_{{{{\rm{D}}}}2}}{{V}_{{{{\rm{D}}}}1}\,+\,{V}_{{{{\rm{D}}}}2}}\right]$ is shown with a solid line with the proportional coefficient ($K$) and goodness of fit ($G$) listed in the top right corner The cell volume asymmetry between each pair of daughter cells is averaged over eight wild-type uncompressed replicates and 17 wild-type compressed replicates The statistical significance is obtained by the one-sided Wilcoxon rank-sum test and is listed in the bottom left corner C The apoptotic cells (vertical) are mostly smaller in volume compared to their sisters (horizontal) upon their birth Shown are average volumes of 93 non-apoptotic and apoptotic sister-cell pairs recorded in the eight wild-type embryos 80 of which have a relatively smaller volume for the apoptotic cells D The illustration for asymmetric divisions of three representative parents of apoptotic cells from the AB (left) only cellular morphology at the time points before and after cytokinesis is shown Whether the simultaneous changes in cell volume and cell irregularity are causally related remains an interesting question that warrants further exploration A The main graphical user interface of ITK-SNAP-CVE B The visual representations of all cells within an embryo using the software’s “Show all cells” display mode with 2D views (top) and 3D reconstructions (bottom) C–E The detailed visualization of a selected individual cell as seen through different viewing options: Panel (C) “Show master cells only” display mode Panel (D) “Show master cells and neighbors” display mode highlighting the “C” cell along with its immediate neighboring cells Panel (E) “Show master cells and other cells” display mode where the “C” cell is visible in the context of the entire cell population F A comprehensive view of all cells derived from the same lineage demonstrating the lineage-specific visualization capabilities of the software G A display of all cells that are destined to become part of the same organ illustrating the software’s functionality to group cells by their developmental fate elegans embryonic cells and the associated methodology and tools developed in this study are expected to facilitate addressing these questions among many others The biological discoveries integrating the morphological map with biochemical experiments are valuable but necessitate further validation. Taking the identification of Notch signaling (Fig. 6) as an example gene expression profiling and RNAi treatment were utilized for validation or direct Notch signaling activity monitoring by tracing the nucleus import of the Notch intracellular domain achieving a comprehensive understanding of morphological and biochemical processes requires multiple parallel lines of evidence The morphological map and experimental-computational methodology generated in this study will facilitate the detailed characterization of cellular and molecular control of embryogenesis with exceptional spatial and temporal resolution future work should focus on the development of a more robust segmentation algorithm to deal with image deficiencies alternative imaging methods to compensate for signal loss over laser passages or insufficient z-axis resolution and transgenic strains that demonstrate uniform expression of membrane signals with a higher signal-to-noise ratio elegans excretory cell at postembryonic stages Time-lapse 3D imaging is similar to the one in our previously established data collection protocol12 with the following modifications to eliminate mechanical compression applied to the embryos Embryos were mounted on a polylysine-pretreated glass slide to immobilize them during imaging Instead of using glass beads that have a slightly smaller diameter than that of embryos Vaseline was dotted outside the four corners of the polylysine pad to support the coverslip without touching the embryos to be imaged one- to four-celled embryos were retrieved from young adults (hermaphrodite) using a mouth pipette for mounting double-stranded RNAs for lag-1 and pop-1 were synthesized in the test tube and injected into both gonads of young adults (hermaphrodite) One- to four-celled embryos were retrieved from the injected animals 12–24 h after injection 12 µL of Boyd’s buffer was added on the polylysine pad before embryo transfer The coverslip was gently placed on top of the buffer and pushed to the proximity of embryos by applying gentle pressure on the Vaseline on each corner of the polylysine pad The edges of the coverslip were sealed with melted Vaseline before imaging Images were continuously collected for at least a total of 240 time points during which the cell count would reach up to 550 and 330 in wild-type and RNAi-treated embryos The entire imaging duration was divided into five blocks to accommodate fluorescence signal variation over development (1–60 The z-axis compensation was 0.5-3% for the 488 nm laser and 20-95% for the 594 nm laser The pinhole sizes for the five blocks were 2.3 all images were subjected to deconvolution and renaming for automated tracing and lineaging imaging settings were the same as those used for the embryo except that the z-axis resolution is 1 µm/pixel for the adult and 0.42 µm/pixel for the embryo The automated tracing and lineaging results were manually curated up to beyond the 550-cell stage when all the progeny of the founder cell “C” were born and present for at least five time points including spatial position and cell identity at each time point was output as a separate file to be used as input by CMap was proposed for automatically segmenting 3D fluorescence images also known as cellular volumetric segmentation The proposed method includes three successive parts: (1) Interpolation is performed for the 2D TIFF images (x/y-axis resolution: 0.09 μm/pixel) collected with a z-axis resolution of 0.42 μm/pixel transforming them into 3D NIfTI images with designed sizes and equal resolutions in all the x and z directions; (2) A deep 3D neural network the Euclidean distance transform dilated multifiber network (EDT-DMFNet) predicts the probability that a single pixel belongs to cell membrane; (3) With the probability map the segmented instances corresponding to multiple separate 3D cell objects are generated The details of these three parts are elaborated below the fluorescence images at each time point were originally collected from xy focal planes along the z axis (i.e. the depth direction z is perpendicular to the focal plane Its corresponding pixel number along x (the width of the focal plane) and y (the height of the focal plane) axes are 712 and 512 the pixels whose fluorescence intensity is within the highest and lowest 1% of the global range were discarded the 3D image underwent spatial resampling with downsampling along the x and y axes from 712 × 512 to 356 × 256 and upsampling along the z axis from 92 to 214 EDT-DMFNet utilized a weighted fully dilated convolution to summarize the features at different scales adaptively While group convolution was used to implement channel-wise convolution for a small network which is composed of several 1×1×1 filters was applied to route the information among groups EDT-DMFNet transforms the segmentation task from a pixel classification problem to a pixel probability map regression problem namely the inference on the probability map of pixels belonging to cell membrane $P\in {\left[{{\mathrm{0,1}}}\right]}^{W\times H\times D}$ according to the input image ${I}_{0}\in {\left[{{\mathrm{0,255}}}\right]}^{W\times H\times D}$ allows multiple cell objects segmentation with limited computational resources with high speed and depth (along z axis) of 3D stack images the Softmax activation function at the output layer was replaced with the Sigmoid activation function for probability prediction An adaptive membrane-centered weighted loss $L$ was used to measure the difference between the target map (the ground-truth data) $I$ and the predicted probability map $\hat{I}$ The loss $L$ of a 3D volumetric image was calculated by taking the weighted average of the mean squared error (MSE) between the target map $I$ and the probability map $\hat{I}$ the adaptive membrane-centered weighted mask ${W}_{{{{\rm{mask}}}}}$ is defined as ${W}_{{{{\rm{mask}}}}}=\mu \cdot I+{avg}\left\{I\right\}$ where $\mu$ is a constant (0.2) that scales the probability map $\hat{I}$ and ${avg}\left\{I\right\}$ is the average value of $I$ over the entire 3D volumetric image the pixels of the predicted probability map $\hat{I}$ nearby cell membranes become more significant with the weighted mean squared error the weighted mask substantially enhanced the contributions of non-zero pixels in the loss function because the non-zero value represents the probability of a pixel belonging to cell membrane in the predicted probability map $\hat{I}$ the pixels of the target map $I$ surrounding the cell membrane should accordingly generate larger values in the weighted mask ${W}_{{{{\rm{mask}}}}}$ the loss grows rapidly if the EDT-DMFNet makes the wrong prediction for the pixels near the cell membrane effectively encouraging the network to focus on the cell membrane and its surrounding pixels the input image$\,{I}_{0}$ was imposed with random noises which realized the augmentation of the training data and ensured the robustness of the network The Adam optimizer was employed to update the network with an initial learning rate of $5\times {10}^{-3}$ and a weight decay rate of $1\times {10}^{-5}$ using AMSGrad gradient descent optimization The model was trained for 50 epochs with a batch size of eight on an NVIDIA 2080 Ti GPU is a probability map as well as a Euclidean distance map for a 3D volumetric image which will be subjected to the subsequent multiple cell objects segmentation Based on the nucleus marker-seeded watershed algorithm as described previously108 CMap pre-inserts the experimentally established positions of cell nuclei into the Euclidean distance map $\hat{I}$ This strategy confers solid cell position information to cell membrane segmentation as guidance cues The cell nucleus marker-based watershed algorithm successfully improved the segmentation performance of CMap for C avoiding under- and over-segmentation problems especially at the stage with over 350 cells in the embryo when cells become smaller and more crowded with a deteriorated signal-to-noise ratio Such panoramic cell segmentation was executed up to the last time point with manual curation of automated lineage in each embryo By perturbing the pixels’ intensity and randomly flipping and cropping an image the 54 3D stack images in the training dataset were augmented to 21,600 effective training 128 × 128 × 128 cube images which significantly improves the robustness of the trained EDT-DMFNet for other wild-type embryonic images The protocols for data augmentation in training are described below Random intensity scale change: the intensity of all pixels in each training image was scaled with a uniform distribution Random intensity shift change: the intensity of all pixels in each training image was shifted with a uniform distribution Random flip: each training image had a 50% chance to be flipped along the x Random crop: each training cube image was cropped randomly as $[128,\,128,\,128]$ from the original size $[205,\,285,\,134]$ The ground truth of cell morphology is necessary for evaluating the performance of machine segmentation algorithms. In this study, the cell morphology of two embryos, WT_Sample1 and WT_Sample7 (Fig. S11) was annotated by ten well-trained experts based on the segmentation results from CMap and the raw fluorescence images The segmentation results were strictly checked and corrected slice by slice and cell by cell ensuring the correctness of the ground truth established we gained two sets of ground truth data in different dimensions the middle slice at each imaging time points throughout embryogenesis (255 2D images for WT_Sample1 and 205 for WT_Sample7) was annotated for 2D comparison providing the cross-section of 30,509 cell objects in total and 550 ± 5-cell stages (six 3D images each of WT_Sample1 or WT_Sample7) were annotated for 3D comparison providing the full morphology of 4046 cell objects in total in order to study the advantages and disadvantages of each algorithm Note that VNet is a semantic segmentation network so we integrated the instance segmentation part of CShaper into its binary output for subsequent performance evaluation All six algorithms were trained through the same pipeline elegans wild-type embryo sample was imaged for a duration with the following criteria: The last moment of the four-cell stage must be recorded each of which has at least five time points recorded The final recognized cell number must be over 570 and the total edited time points must be no less than 185 ( ≈ 265 min) The results of cell tracing and lineaging were subjected to manual editing according to the procedures: For each cell with a complete lifespan recorded in all embryo samples its normalized cell cycle lengths in all embryos are noted as [L1 The top 10% cells with the largest max([L1 L8]) and the bottom 10% cells with the smallest min([L1 For each 3D region marked by cell identity c we characterized its volume dynamics with three characteristics: The relative difference in volume between daughter cells and their mother is defined as where $V\left({c}_{1},j,t\right)$ and $V\left({c}_{2},j,t\right)$ are the volumes of two daughter cells ${c}_{1}$ and ${c}_{2}$ at time point $T$; $\hat{V}\left({p}_{0},j\right)$ is the median volume of the mother cell ${p}_{0}$ throughout its lifespan The volume inconsistency of cell $c$ at two consecutive time points $T+1$ and $T$ is defined as The volume variation of cell $c$ at a specific time point $T$ is defined as if a specific cell at a specific time point belongs to the top 1/30 ≈ 3.33% outliers in all three criteria The target cell was traced manually under direct observation Immediately after the target cell was born the following procedures were conducted within 1.5 min and the focus was adjusted to the midplane of the target cell The bleaching point was selected at the center of the target cell in the focal plane and shutters for all other wavelengths were temporarily closed and then the bleaching process was initiated the standard time-lapse 3D imaging resumed As a subset of the 3D cell objects segmented by CMap were apparently wrong we devised a pipeline to filter them out from the last time point of the four-cell stage to the last edited time point for every embryo sample Six strategies were applied as listed below A cell region is filtered out if it has a volume on the left of the valley of the bimodal distribution The existence of separate regions SR, which disobeys the space continuity of cell shape: A cell region is filtered out if it contains two cell nuclei inside but neither the middle point nor the two quarter points between them belong to the cell region (Fig. S10) The filter rate FRL of lifespan recorded: A cell region is filtered out if over half of the time points within the lifespan of this cell have been filtered out by the five criteria above (Figs. S8E and S10) To ensure that the massive data brought to the public is in the correct format we wrote independent code to check its different aspects Every cell recorded in “SegCell\<embryo sample > _<time point > _segCell.nii.gz” is included in “<embryo sample > _lifescycle.csv” and “TPCell\<embryo sample > _<time point > _cells.txt” Every cell recorded in “SegCell\<embryo sample > _<time point > _segCell.nii.gz” has been recorded in “name_dictionary.csv” and has a volume recorded in “<embryo sample > _volume.csv” and a surface area recorded in “<embryo sample > _surface.csv” Every cell recorded in “SegCell\<embryo sample > _<time point > _segCell.nii.gz” has a volume and a surface area recorded in “<embryo sample > _<time point > _nucLoc.csv” Every cell with a volume recorded in “<embryo sample > _volume.csv” and a surface area recorded in “<embryo sample > _surface.csv” has a corresponding segmented region recorded in “SegCell\<embryo sample > _<time point > _segCell.nii.gz” Every cell with a volume and a surface area recorded in “<embryo sample > _<time point > _nucLoc.csv” has a corresponding segmented region recorded in “SegCell\<embryo sample > _<time point > _segCell.nii.gz” The cell in “<embryo sample > _<time point > _nucLoc.csv” without a volume and a surface area recorded has a nucleus recorded in “Tracing_<embryo sample > .csv” Every cell nucleus at a specific time point recorded in “Tracing_<embryo sample > .csv” is also recorded in “<embryo sample > _<time point > _nucLoc.csv” Every cell-cell contact recorded in “GuiNeighbor\<embryo sample > _<time point > _guiNeighbor.txt” has an area recorded in “<embryo sample > _Stat.csv” while the contacting cells have corresponding segmented regions recorded in “SegCell\<embryo sample > _<time point > _segCell.nii.gz” Every dividing cell recorded in “DivisionCell\<embryo sample > _<time point > _division.txt” has no nucleus recorded in “Tracing_<embryo sample > .csv” but the nuclei of its two daughter cells are recorded Every dividing cell recorded in “DivisionCell\<embryo sample > _<time point > _division.txt” has a volume recorded in “<embryo sample > _volume.csv” and a surface area recorded in “<embryo sample > _surface.csv” If its division ends before the terminal edited time point there is a volume recorded in “<embryo sample > _volume.csv” and a surface area recorded in “<embryo sample > _surface.csv” for its two daughter cells Every dividing cell recorded in “DivisionCell\<embryo sample > _<time point > _division.txt” is included in “<embryo sample > _lifescycle.csv” and “TPCell\<embryo sample > _<time point > _cells.txt” and has a corresponding segmented region recorded in “SegCell\<embryo sample > _<time point > _segCell.nii.gz” the parallel gene expression profiles from different individual embryo samples with the same labeled gene and the same literature source were averaged and linearly normalized to 0 ~ 1 which was then superimposed on the cell lineage and morphological data of the eight segmented C elegans wild-type embryos at each time point by proportionally fitting the differential developmental paces; if there’s only one embryo sample with the same labeled gene the processing procedure for the gene expression profile is the same except that no averaging operation was executed No data were excluded from the subsequent analyses all embryo samples were derived from the same experimental condition (“Methods”) data from all embryos (or units) were used together Further information on research design is available in the Nature Portfolio Reporting Summary linked to this article The strain (ZZY0861) used for cell morphology reconstruction by CMap is available from the Zhao Lab It can also be ordered through the Caenorhabditis Genetics Center (CGC) A reference cell tree will serve science better than a reference cell atlas Systematic reconstruction of cellular trajectories across mouse embryogenesis elegans embryogenesis at single-cell resolution A single-cell time-lapse of mouse prenatal development from gastrula to birth single-cell time-resolved model for mouse gastrulation The first two blastomeres contribute unequally to the human embryo Cell interactions and patterned intercalations shape and link epithelial tubes in C Caenorhabditis elegans gastrulation: A model for understanding how cells polarize and journey toward the center of an embryo Integrating cellular dimensions with cell differentiation during early development Establishment of a morphological atlas of the Caenorhabditis elegans embryo using deep-learning-based 4D segmentation Cellular shape reinforces niche to stem cell signaling in the small intestine Phosphoproteome and gene expression profiling of ALK inhibition in neuroblastoma cell lines reveals conserved oncogenic pathways The maternal genes apx-1 and glp-1 and establishment of dorsal-ventral polarity in the early C Time-dependent responses to glp-1-mediated inductions in early C The ref-1 family of bHLH transcription factors pattern C elegans embryos through Notch-dependent and Notch-independent pathways pop-1 encodes an HMG box protein required for the specification of a mesoderm precursor in early C Notch signaling and morphogenesis of single-cell tubes in the C elegans zygote ensures invariably successful embryogenesis Power law relationship between cell cycle duration and cell volume in the early embryonic development of Caenorhabditis elegans Setting the clock for fail-safe early embryogenesis Volume segregation programming in a nematode’s early embryogenesis Computable early Caenorhabditis elegans embryo with a phase field model Systems‐level quantification of division timing reveals a common genetic architecture controlling asynchrony and fate asymmetry Why and how the nematode’s early embryogenesis can be precise and robust: A mechanical perspective Contact area–dependent cell communication and the morphological invariance of ascidian embryogenesis Real-time three-dimensional cell segmentation in large-scale microscopy data of developing embryos Biologically constrained optimization-based cell membrane segmentation in C The embryonic cell lineage of the nematode Caenorhabditis elegans The lineaging of fluorescently-labeled Caenorhabditis elegans embryos with StarryNite and AceTree Automated cell lineage tracing in Caenorhabditis elegans AceTree: A major update and case study in the long-term maintenance of open-source scientific software The Caenorhabditis elegans transgenic toolbox CRISPR-Based Methods for Caenorhabditis elegans genome engineering Multidimensional regulation of gene expression in the C A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis 3DMMS: Robust 3D membrane morphological segmentation of C spheresDT/Mpacts-PiCS: Cell tracking and shape retrieval in membrane-labeled embryos Delineating mechanisms and design principles of Caenorhabditis elegans embryogenesis using in toto high-resolution imaging data and computational modeling Establishment of signaling interactions with cellular resolution for every cell cycle of embryogenesis CShaperApp: Segmenting and analyzing cellular morphologies of the developing Caenorhabditis elegans embryo Establishment of left-right asymmetry in the Caenorhabditis elegans embryo: A multistep process involving a series of inductive events Altun, Z. 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WormAtlas. https://doi.org/10.3908/wormatlas.1.13 (2009) elegans blastomere to distinguish endoderm from mesoderm elegans intestine involves axon guidance genes Altun, Z. F. & Hall, D. H. Muscle system, somatic muscle. WormAtlas. https://doi.org/10.3908/wormatlas.1.7 (2009) Multilevel regulation of muscle-specific transcription factor hlh-1 during Caenorhabditis elegans embryogenesis Eisenmann D. M. Wnt signaling. WormBook. https://doi.org/10.1895/wormbook.1.7.1 (2005) Endoderm development in Caenorhabditis elegans: The synergistic action of ELT-2 and -7 mediates the specification->differentiation transition Timing of tissue-specific cell division requires a differential onset of zygotic transcription during metazoan embryogenesis Chiral Forces Organize Left-right patterning in C elegans by uncoupling midline and anteroposterior axis Large-scale screening for targeted knockouts in the Caenorhabditis elegans genome Uncoupling different characteristics of the C elegans E lineage from differentiation of intestinal markers Priess, J. R. Notch signaling in the C. elegans embryo. WormBook. https://doi.org/10.1895/wormbook.1.4.1 (2005) Anti-correlation of cell volumes and cell-cycle times during the embryogenesis of a simple model organism Notch-dependent induction of left/right asymmetry in C a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans is homologous to human CBF1 and Drosophila Su(H) Quantitative differences in nuclear β-catenin and TCF pattern embryonic cells in C The CSL transcription factor LAG-1 directly represses hlh-6 expression in C Stability of asymmetric cell division: A deformable cell model of cytokinesis applied to C Functional study of the Caenorhabditis elegans secretory‐excretory system using laser microsurgery Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis Insight into transcription factor gene duplication from Caenorhabditis elegans Promoterome-driven expression patterns lin-12 and glp-1 are required zygotically for early embryonic cellular interactions and are regulated by maternal GLP-1 signaling in Caenorhabditis elegans elegans intestine organogenesis involves a LIN-12/Notch signaling pathway Induction of gut in Caenorhabditis elegans embryos elegans embryogenesis driven by reiterated reciprocal asymmetry of TCF POP-1 and its coactivator β-catenin SYS-1 A caspase‐RhoGEF axis contributes to the cell size threshold for apoptotic death in developing Caenorhabditis elegans Caenorhabditis elegans ced-3 caspase is required for asymmetric divisions that generate cells programmed to die elegans MELK ortholog pig-1 regulates cell size asymmetry and daughter cell fate in asymmetric neuroblast divisions ITK-SNAP: An interactive tool for semi-automatic segmentation of multi-modality biomedical images elegans: Their roles in behavior and development Cytoskeletal dynamics in Caenorhabditis elegans axon regeneration Comparison between phase-field model and coarse-grained model for characterizing cell-resolved morphological and mechanical properties in a multicellular system Multiple Wnt signaling pathways converge to orient the mitotic spindle in early C Cellular mechanotransduction: From tension to function Mechanotransduction: From the cell surface to the nucleus via RhoA Inference of cellular level signaling networks using single-cell gene expression data in Caenorhabditis elegans reveals mechanisms of cell fate specification Automated analysis of embryonic gene expression with cellular resolution in C Pani, A. 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O. Blender – A 3D modelling and rendering package. https://www.blender.org (2023) Fiji: An open-source platform for biological-image analysis Guan, G. et al. System-level quantification and phenotyping of early embryonic morphogenesis of Caenorhabditis elegans. Preprint on bioRxiv. https://doi.org/10.1101/776062 (2019) Imaging plant growth in 4D: Robust tissue reconstruction and lineaging at cell resolution Defect-buffering cellular plasticity increases robustness of metazoan embryogenesis Guan, G. Quantitative cell morphology reveals fate-coupled regulation of cell size in C. elegans embryo. figshare. https://doi.org/10.6084/m9.figshare.24768921 (2023) Ye, P., Guan, G. & Li, Z. An online database for visualization and analysis of cell morphologies and gene expressions throughout Caenorhabditis elegans embryogenesis. EE Dept. of CityUHK. https://bcc.ee.cityu.edu.hk/cmos (2024) Li, Z. & Guan, G. CMap additional data/files. figshare. https://doi.org/10.6084/m9.figshare.27872238 (2025) Li, Z. & Cao, J. chiellini/CMap: Release CMap code for Nature Communications paper (v1.0). Zenodo https://doi.org/10.5281/zenodo.14916840 (2025) Li, Z. & Cao, J. chiellini/CMapEvaluation: Release CMap evaluation code for Nature Communications paper (v0.9). Zenodo https://doi.org/10.5281/zenodo.14920949 (2025) AceTree: A tool for visual analysis of Caenorhabditis elegans embryogenesis The MathWorks Inc. MATLAB version: 9.5.0 (R2018b). https://www.mathworks.com (2018) Python Software Foundation. Python Language Reference version: 3.7. http://www.python.org (2018) Download references and Zhao Lab for the fruitful discussion and constructive comments and Cunmin Zhao for improving the paper materials and Ahjol Hyrat for the preliminary analysis of C Kai Kang for the preliminary analysis of gene expression profile and 3D illustration Hung Chim for the assistance in building stable server and website Zhiguang Zhao for providing the summarized information on C John Isaac Murray for instructing the data collection from EPIC The computation of the quantitative and statistical analyses was performed in part on the High-Performance Computing Platform at Peking University The strains used for the newly generated 97 embryos for profiling gene expression were provided by the Caenorhabditis Genetics Center (CGC) which is funded by the National Institutes of Health (NIH) Office of Research Infrastructure Programs (P40 OD010440) This work was supported by the National Natural Science Foundation of China (12090053 32088101) to C.T.; by the Hong Kong Innovation and Technology Commission (ITC) (InnoHK Project CIMDA) Hong Kong Research Grants Council (RGC) (11204821) and the Institute of Digital Medicine of City University of Hong Kong (9229503) to H.Y.; and by the Hong Kong Innovation and Technology Commission (ITC) (GHP/176/21SZ) and Hong Kong Research Grants Council (RGC) (HKBU12101520 Present address: Department of Systems Biology Present address: Department of Data Science Present address: School of Biomedical Engineering Present address: Schulich School of Medicine and Dentistry These authors contributed equally: Guoye Guan Centre for Intelligent Multidimensional Data Analysis conceived and supervised this project; Y.M. and performed automated cell lineage tracing; Z.L and extracted morphological features; G.G. coordinated the manual annotation for ground truth performed data quality evaluation and control carried out the quantitative and statistical analyses; Z.L. designed and improved the CVE software; P.Y. designed and improved the CMOS website; G.G. The authors declare no competing interests reviewer(s) for their contribution to the peer review of this work Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Download citation DOI: https://doi.org/10.1038/s41467-025-58878-0 Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily. 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Something went wrong. Please subscribe again. Get the top stories from across our network. Are you sure you want to unsubscribe from daily updates? A 45-year-old Morristown man was sentenced to 46 years in prison last week after previously being convicted of sexually assaulting a child, authorities said. Alexander MasariegoFlores was convicted last December of three counts of aggravated sexual assault, two counts of second degree sexual assault and two counts of endangering the welfare of a child, Morris County Prosecutor Robert Carroll, Chief of Detectives Robert McNally, and Morristown Chief of Police Darnell Richardson said. Between February and September 2023, MasariegoFlores sexually assaulted an 8-year-old child, authorities said, with an investigation beginning that September, authorities said. MasariegoFlores sexually abused the child in front of another child, authorities said. A 26-year-old Freehold Borough man was sentenced to five years in prison on Friday, May 2 after previously pleading guilty to shooting a man in the face last year in Jackson Township, authorities said. On Thursday, June 27 at 12:20 a.m., officers in Jackson Township responded to Larsen Road and found a 27-year-old man with a gunshot wound to the face, Ocean County Prosecutor Bradley Billhimer said. He was transported to Jersey Shore University Medical Center in Neptune where he was treated and subsequently released, Billhimer said. The victim and a woman were sitting in a parked vehicle outside a residence when a blue sedan parked in front of their vehicle, blocking them in, Billhimer said. Michael Vulpis and Noah Phelps, a 24-year-old Monroe Township resident, knocked on the window and as the victim exited, he was assaulted and then shot in the face, Billhimer said. Vulpis and Phelps were arrested following the attack, Billhimer said. Vulpis pleaded guilty to aggravated assault with a deadly weapon, Billhimer said. Further investigation revealed Glenn Franzson, a 32-year-old Jackson Township resident, conspired with Vulpis to contact the victim after the shooting, to have him provide a false statement to law enforcement in reference to the investigation. Billhimer said. As a result, Franzson was charged with witness tampering and conspiracy to commit witness tampering, Billhimer said. The charges against Phelps and Franzson remain pending. “The State is required to prove each and every element of a crime beyond a reasonable doubt," Billhimer said. "Where, as in this case, the victim of a crime remains uncooperative with the prosecution’s efforts, it makes it extremely difficult, if not impossible, for the State to satisfy its legal burden of proof. As such, the State reluctantly entered into this negotiated resolution - in the absence of victim cooperation - so that some level of justice might nevertheless be accomplished." 2025Vindictus: Defying Fate - Official Karok Character TrailerTake a look at the Karok Character Trailer for Vindictus: Defying Fate an action-adventure RPG developed by Nexon Players will become acquainted with the fearsome Karok fitted with a towering presence and devastating strength Get a glimpse at some of Karok's moves and more in the latest trailer for Vindictus: Defying Fate FlaglerLive May 4, 2025 | FlaglerLive | Leave a Comment The Supreme Court on Wednesday was divided over a Catholic virtual charter school’s bid to become the country’s first religious charter school With Justice Amy Coney Barrett recused from the case the outcome appeared to hinge on the vote of Chief Justice John Roberts who asked probing questions of both sides but did not make his position clear is a public school and therefore required under state law to be non-religious stand for the proposition that when the government makes benefits or funds generally available to the public it cannot exclude people or groups from such programs just because they are religious Justice Ketanji Brown Jackson also appeared dubious that the Trinity Lutheran line of cases was necessarily applicable here the Supreme Court ruled that a state can opt to provide a strictly secular education in its public schools is not being denied a benefit that everyone else is receiving but is instead being denied a benefit that no one else gets – the ability to establish a religious public school it would have been a different story if St Isidore wanted to establish a secular public school but its application was rejected because it is a religious institution Another key focus of the argument was whether St Isidore is a private actor that has a right to the free exercise of religion or is instead a government entity or a state actor Justice Neil Gorsuch seemed receptive to this characterization He later observed that if the lack of supervision by a school’s board resulted in a determination that a charter school is not a government entity states could respond by initiating more oversight for charter schools – for example Justice Samuel Alito focused on comments made by Drummond in opposing St Isidore’s application to open a virtual charter school Isidore’s application would mean that the board would also have to approve a religious charter school operated by a minority religion a “very serious Masterpiece Cakeshop problem,” referring to the 2018 case of a Colorado baker who refused to make a custom wedding cake for a same-sex couple The court issued a narrow ruling for the baker finding that a Colorado administrative agency had been too hostile to his sincerely held religious beliefs The opposition “reeks of hostility to” Islam The justices also spent time exploring the implications of a ruling in either direction Kagan described a hypothetical involving a school in a Hasidic community in New York that wanted to adopt a curriculum focused on the Talmud and other ancient texts Does New York have to approve this charter school even though the curriculum is “super different” The state wanted to adopt a charter-school program to offer flexibility but a ruling for the charter school in this case would require it to fund all kinds of religious schools if it wants to have programs at all Gorsuch countered that it might be a “neutral rule” to require charter schools to teach a standard curriculum that included subjects like math one of the justices who was most openly sympathetic to the charter school echoed the arguments by the school and the board that upholding the Oklahoma Supreme Court’s opinion could mean that other faith-based services like Catholic Social Services or Catholic Charities would also be deemed government entities and be unable to exercise their religion telling Kavanaugh that the other faith-based services are not established by the state itself observing that Catholic Social Services could in fact provide adoption services only with “incredible oversight” from the city would we draw the line between faith-based services that would or would not be government entities “We have to have a test,” Gorsuch concluded Garre told the justices that if they rule for the board and the school it will have a “dramatic effect” on the charter-school system that both the federal law governing charter schools and virtually all state charter-school laws would also be unconstitutional because they require charter schools to be “non-sectarian.” Congress and state governments could adopt new laws but in the interim he contended that there would be “uncertainty The Individuals with Disabilities Education Act the federal law ensuring that students with disabilities receive a free appropriate public education applies to charter schools because they are understood to be public schools But that understanding could be upended by a ruling for the school and the board And if religious schools can qualify as public charter schools it will raise questions about who can be admitted to such schools and what the curricula at those schools will be But several of the justices saw the issue before the court very differently the religious schools weren’t asking for favoritism; they were simply seeking not to be excluded from the charter-school program based on their religion The school and the board appeared to have four votes – Justice Clarence Thomas along with Alito Whether the chief justice will join them to overturn the Oklahoma Supreme Court’s decision seems possible Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" This site uses Akismet to reduce spam. Learn how your comment data is processed. Log in “If we approach nature and the environment without [an] openness to awe and wonder if we no longer speak the language of fraternity and beauty in our relationship with the world unable to set limits on their immediate needs if we feel intimately united with all that exists then sobriety and care will well up spontaneously.” – Pope Francis, Laudato Si’: On Care for Our Common Home On the day Pope Francis released his encyclical on the fate of the Earth I was struggling to climb a near-vertical cliff on the Parajito Plateau of northern New Mexico My fingers gripped tightly to handholds notched into the rocks hundreds of years ago by Ancestral Puebloans the anodyne phrase now used by modern anthropologists to describe the people once known as the Anasazi The day was a scorcher and the volcanic rocks were so hot they blistered my hands and knees confessed that the heat radiating off the basalt had made him feel faint although perhaps he was simply trying to make me feel less like a weather wimp When we finally hurled ourselves over the rimrock to the top of the little mesa the ruins of the old city of Puyé spread before us two watchtowers rose above the narrow spine of the mesa top guarding the crumbling walls of houses that once sheltered more than 1,500 people I was immediately struck by the defensive nature of the site: an acropolis set high above the corn squash and bean fields in the valley below; a city fortified against the inevitable outbreaks of turbulence and violence unleashed by periods of prolonged scarcity the shattered remnants of exquisitely crafted bowls and jars all featuring dazzling polychromatic glazes Some had been used to haul water up the cliffs of the mesa an arduous and risky daily ordeal that surely would only have been undertaken during a time of extreme environmental and cultural stress “They came here after the lights went out at Chaco,” Elijah tells me He’s referring to the great houses of Chaco Canyon was ruled for four hundred years by a stern hierarchy of astronomer-priests until it was swiftly abandoned around 1250 AD “Something bad happened after the waters ran out.” He won’t go any further and I don’t press him sit in the blue shadow of the Jemez Mountains scientists are still at work calculating the dark equations of global destruction down to the last decimal point kivas and cave dwellings was itself abandoned suddenly around 1500 Its Tewa-speaking residents moved off the cliffs and mesas to the flatlands along the Rio Grande ten miles to the east near the site of the current Santa Clara (St they would encounter an invading force beyond their worst nightmare: Coronado and his metal-plated conquistadors Again, it was a prolonged drought that forced the deeply egalitarian people of Puyé — the place where the rabbits gather — from their mesa-top fortress. “The elders say that the people knew it was time to move when they saw the black bears leaving the canyon,” Elijah told me. Elijah is a descendant of one of the great heroes of Santa Clara Pueblo: Domingo Naranjo a leader of the one true American Revolution the son of an escaped slave of the Spanish That glorious rebellion largely targeted the brutal policies of the Franciscan missionaries enslaved and butchered the native people of the Rio Grande Valley for nearly 100 years Naranjo supervised the razing of the Church the Franciscans had erected — using slave labor – in the plaza of Santa Clara Pueblo Now the hope of the world may reside in the persuasive powers of a Franciscan reads like a tract from the Deep Ecology movement of the 1980s Pope Francis depicts the ecological commons of the planet being sacrificed for a “throwaway culture” that is driven by a deranged economic system whose only goal is “quick and easy profit.” As the supreme baptizer Francis places a special emphasis on the planet’s imperiled waters both the dwindling reserves of freshwater and the inexorable rise of acidic oceans heading like a slow-motion tsunami toward a coast near you Climate change has gone metastatic and we are all weather wimps under the new dispensation a city whose water greed has breached any rational limit meekly await a reckoning with the Great Thirst as if Dante himself had supervised the zoning plans The Phoenix of the future seems destined to resemble the ruins of Chaco I am writing this column in the basement of our house in Oregon City which offers only slight relief from the oppressive heat outside The temperature has topped 100 degrees again Even non-believers are left to heed the warnings of the Pope and follow the example of the bears of the Jemez Yet now there is no hidden refuge to move toward There is only a final movement left to build a global rebellion against the forces of greed and extinction it will either be a long time coming or a long time gone This is excerpted from The Big Heat: Earth on the Brink USA; Former Colorado Buffaloes players Shedeur Sanders (L) and Travis Hunter (R) during their number retirement ceremony before the spring game at Folsom Field Compelling NFL Debut Under Intense Scrutiny Stepping onto the professional stage is never easy especially when high expectations and contrasting narratives from a collegiate career follow closely Here stands a young quarterback celebrated for his dazzling college displays and the legacy of his celebrated father yet now facing a transformative and challenging moment in the NFL Emerging as the face of his college program this quarterback captivated fans with a record-breaking final season—amassing 4,134 passing yards and 37 touchdowns His ability to shine on the field was nurtured in an environment where a strong support system including prominent mentorship from influential figures transitioning from college stardom to the professional game demands rapid adaptation to higher stakes and relentless pressure Navigating Team Dynamics and Uncertain Futures Within a team scenario that currently holds five quarterbacks on its roster the young quarterback must differentiate himself quickly to secure a lasting role The dynamic within the squad could compel management to consider roster adjustments and if he does not impress swiftly under NFL conditions the opportunity may be lost as swiftly as it appears One stark observation encapsulated the challenge ahead: “His NFL journey may begin with a rude awakening Coloradans who once cheered for their star should prepare for the very real possibility that he might be released before the regular season kicks off.” Comparative Evaluation and Future Prospects it is expected to nurture emerging talent for the future The contrast between this quarterback’s collegiate prominence and his current standing—as just another contender in a crowded field—underscores the dramatic shift in expectations While the option to transition away from other prospects might be viable the talent and resilience etched in his track record suggest that he deserves an honest chance to prove himself early in his professional career This crossroads is more than a simple roster decision; it mirrors the broader struggles many collegiate stars face when entering the NFL It invites reflection on what constitutes true success at the highest level of competition—be it raw talent or the ability to adapt under relentless pressure The situation encapsulates the fine line between potential and performance and prompts a deeper inquiry into how star athletes must evolve once the glitter of college fame dims the unfolding narrative reminds us that the journey from promise to permanence in the NFL is fraught with unexpected challenges The lessons learned on this path may well define not only his career but also serve as a broader testament to the transformative nature of professional sports—where every moment is an opportunity to rise or fall A New Chapter of Excellence In a season poised to rewrite the narrative of college football one athlete stands at the crossroads of redemption and greatness A Journey Defined by Resilience In the fast-paced world of professional football rising stars often face daunting obstacles on their path to greatness A New Chapter Unfolds In an inspiring twist of fate professional gridiron athletes once overlooked by the NFL are now rewriting the narrative of their careers in Mexico’s.. Reviving a Veteran’s Legacy In a bold resurgence that has captured the imagination of fans and experts alike a seasoned quarterback known for his resilience is once again.. An unexpected transition has sent ripples through the NFL landscape marking the end of an era for one of the game's most distinguished specialists © 2025 M Sports - Premium news & magazine M Sports Please enter your username or email address to reset your password © 2025 M Sports - Premium news & magazine M Sports. Men’s Golf Learns NCAA Postseason Fate on Wednesday4/29/2025 1:09:00 PM | Men's Golf NCAA Selection Show to air at Noon, Wednesday, on Golf Channel; Cougars to watch show in Dave Williams Facility at Golf Club of Houston The 2025 NHL Draft Lottery will be held on Monday We're just two days away from finding out if a franchise-altering decision favors the NY Islanders Things will be a bit different than years past. Previously, we've seen NHL Deputy Commissioner Bill Daly reveal the envelopes with each team's logo, symbolizing the order of the draft with NHL Commissioner Gary Bettman overseeing the process we'll see the actual process played out live The NHL Draft Lottery will be played out live "There will be anticipation like you've never seen in a draft lottery, and I truly believe we're the first ones in any league to try this," said Steve Mayer, NHL president of content and events, according to NHL.com "We're always looking to be innovative -- and not innovative for the sake of doing it We've really thought this through and think it's going to be really compelling for our fans." The lottery consists of two draws - one to determine the first and second overall picks The San Jose Sharks have the highest odds of receiving the first overall pick with a 25.5% chance "It's so nerve-wracking as one ball comes out after the other," Mayer said "There are these sheets of paper with every combination possible and the team associated with every combination you're quickly trying to look up who has a chance." The Islanders haven't won the Draft Lottery since 2009, when they were victorious in the John Tavares sweepstakes. With the franchise in search of a new general manager this would be a great way to kick-start the franchise into a new age ","https://fansided.com/",{"alt":"5y","src":"5z","url":"60"},{"type":"5x","value":"61"},"link","Minute Media","https://www.minutemedia.com/",{"text":"64","url":"65"},{"type":"63","value":"66"},"All Rights Reserved Things will be a bit different than years past. Previously, we've seen NHL Deputy Commissioner Bill Daly reveal the envelopes with each team's logo, symbolizing the order of the draft "There will be anticipation like you've never seen in a draft lottery, and I truly believe we're the first ones in any league to try this," said Steve Mayer, NHL president of content and events, according to NHL.com The Islanders haven't won the Draft Lottery since 2009, when they were victorious in the John Tavares sweepstakes. With the franchise in search of a new general manager, this would be a great way to kick-start the franchise into a new age. The NHL Draft Lottery will have a new look this year With General Motors leaving its longtime headquarters at the Renaissance Center the fate of Detroit’s largest structure is not yet set Motor City officials and preservationists see different futures for RenCen the soon-to-be-former headquarters of General Motors and once the world’s largest development concern over the fate of downtown Detroit’s most recognizable structure turned into speculation that the distinctive skyscraper complex would be demolished plans to take down two of its five office towers — and then some — are proceeding has tasked Gensler and James Corner Field Associates with reimagining the nearly half-century-old mega-complex Their $1.6 billion concept involves significantly reducing its 5.5-million-square-footage by demolishing two of its original five towers as well as an early 2000s podium addition while creating new public outdoor spaces that connect to the Detroit River but some recent news regarding Ncuti Gatwa and Eurovision has me optimistic that a renewal is on the way the latest news of him being a part of one of the biggest music competitions in the world has me thinking otherwise and why I'm feeling way more optimistic about seeing the sci-fi series again Douze Points (or should that be fifteen?) for #DoctorWho! 🎶Ncuti Gatwa will be the UK's jury spokesperson for this year’s #Eurovision Song Contest, delivering the UK points to the world! #Eurovision2025 pic.twitter.com/2Csi3MItW9May 2, 2025 and one that has me more optimistic than not we're going to see Doctor Who return for another season Beyond the fact I've seen this franchise brush off past claims it was on its final leg I think there's something to the fact that the franchise is working so closely with Eurovision Wholesome entertainment for all the family starting at $9.99 a month for its new ad-supported plan Go ad-free and pay $15.99 a month or save 16% and pre-pay $159.99 for a year While I'm sure it was no coincidence Russell T. Davies intended to do a Eurovision parody episode during the actual competition I can't imagine that The BBC would be keen on inviting Ncuti Gatwa to be a major representative for the UK's portion if Doctor Who could realistically by canceled by the end of the year I feel like doing so would be a bit embarrassing for the network I'll admit my bravery in maintaining Doctor Who will survive another season stems from the cryptic Mrs. Flood who broke the fourth wall again at the start of the season proclaiming the end of the series was near I have a suspicion that the network and RTD have leaned into news of the series ending in order to further bolster the storyline and what's coming in the season finale Whether Ncuti Gatwa will still be The Doctor when Doctor Who returns is another story It's been widely reported that reshoots took place for this current season despite wrapping on it the year prior with suggestions that the scenes filmed were for Gatwa's regeneration scene and while we have no confirmation the star is exiting one does have to question what reshoots had to occur just a couple of months before the premiere date I prefer to stay optimistic and think that we'll get more of Gatwa and his crying Doctor for at least one more season Catch new episodes of Doctor Who on Disney+ on Saturdays. This season is already off to a strong start, so be sure to catch up and keep up with one of the best sci-fi shows on the 2025 TV schedule but he also regularly reports on happenings in the world of Star Trek He graduated from the University of Southern Indiana with a degree in Journalism and a minor in Radio and Television He's great at hosting panels and appearing on podcasts if given the chance as well you will then be prompted to enter your display name A Comedian Weighs In On His Legal Issues And How They’ll Impact ‘The Culture’ There Are Some Brutal Kills In Tom Hardy's Havoc But One Had My Wife And Me Gasping (And Laughing) In Disgust Jamie Lee Curtis Just Showed Off What It's Like To See Sinners In 70mm IMAX New York Jets quarterback Aaron Rodgers (8) may have played his last game for Gang Green An air of suspense surrounds Pittsburgh’s quarterback future with the team’s fate intricately tied to the decision of a seasoned veteran As one of the league’s most influential passers contemplates hanging up his cleats Pittsburgh faces a crossroads that could redefine its offensive trajectory for years to come The Steelers find themselves at an impasse as they search for stability at the quarterback spot—a position long believed to be the cornerstone of their strategy The focus has centered on a veteran whose illustrious career now teeters between continuing on the field or stepping away for good His candid remarks about being “open to anything and attached to nothing” have only deepened the intrigue around his future plans This admission leaves the organization with a pressing decision and fans with many unanswered questions Evaluating Rodgers’ Legacy and Recent Performance The veteran in question carries the weight of high expectations and a celebrated legacy Despite past accolades and Hall of Fame credentials his recent statistics hint at a decline: his performance has dipped noticeably during his last full seasons with previous teams This contextual background is critical; a storied career intermingled with struggles in recent years creates a compelling narrative around whether his experience can still translate into success in Pittsburgh’s dynamic offensive system Exploring Alternatives and Their Implications In the absence of a definitive commitment from their marquee quarterback Pittsburgh is forced to consider a spectrum of alternatives including promising yet unproven talents and rookies drafted as future prospects Another possibility on the horizon involves pursuing a trade for a veteran known to be solid This situation puts the Steelers in a unique predicament: while their explosive receiving corps boasts remarkable talent their overall success is intertwined with the ability of their quarterback to fully harness and elevate that potential Pittsburgh’s strategy hinges on the imminent decision about whether to commit to a veteran whose expertise comes at a premium—or to pivot swiftly towards emerging talent the organization must weigh short-term ambitions against the potential for long-term growth the integration of seasoned leadership alongside speedy playmakers is crucial A decision to bring in an aging veteran carries its risks yet it also promises the potential for harnessing hard-won experience in high-pressure situations The unfolding quarterback saga is more than just a personnel decision; it reflects broader themes of legacy and the relentless pace of competitive sports As the team awaits clarity from one of the most influential figures in recent football history the implications echo beyond Pittsburgh—offering a reminder of the fine line between brilliance and uncertainty on the grand stage of professional sports This moment underscores the enduring challenge that teams face when balancing past glories with the demands of tomorrow’s victories leaving fans and analysts alike to ponder the future of a storied franchise A Startling Turn in an NFL Career A renowned linebacker’s sudden arrest has sparked a moment of reflection within the league creating ripples that extend far beyond the.. Electrifying Offseason Momentum In a season brimming with promise Cincinnati's journey toward championship contention is set alight by a series of transformative moves A Bold New Beginning In a season brimming with anticipation a new page in football history is being written as Russell Wilson embarks on a transformative journey with.. The pursuit of excellence on the gridiron is forever fraught with unexpected twists and strategic gambles as two storied franchises demonstrate in their quest to revamp their wide.. Electrifying Intersection of Sports In an unexpected blend of gridiron grit and high-octane racing a captivating moment unfolded at a renowned speedway sparking excitement among fans and players.. © 2025 M Sports - Premium news & magazine M Sports VW Sell More EVs, Yet Makes a Lot Less Money Ram Reveals Revamped, Stylish Sub-$50K 1500 Express Home/NewsTesla Board Denies Report Regarding Elon Musk’s FateThe leading EV firm’s Board Chair was quick to respond to the WSJ’s report via a post on X A key executive at Tesla has hit back on social media in response to a scathing Wall Street Journal report that alleged the worst fate for its CEO calling the report published late on April 30 “absolutely false.” In the report “people familiar with the discussions” told the Journal that Tesla’s board of directors initiated a search for a successor for Elon Musk as CEO as recently as “about a month ago.” The same sources also stated that the company reached out to “several” executive search firms and even narrowed down to one firm to lead the search In addition, in a post from his personal X account Musk himself accused the paper of an “EXTREMELY BAD BREACH OF ETHICS,” and also called the report a “DELIBERATELY FALSE ARTICLE” that failed to “include an unequivocal denial beforehand by the Tesla board of directors!” According to the Wall Street Journal report the plans to potentially replace Elon Musk as CEO came as his time with the Department of Government Efficiency (a.k.a DOGE) and the greater Trump Administration had become material while weekends were spent at Trump's Mar-a-Lago residence in Florida Sources who spoke with the Journal noted that Tesla’s board began the supposed replacement process around the same time it reportedly told Musk that he needed to spend more time on Tesla and less on Beltway happenings, and “needed to say so publicly.” Nonetheless, during Tesla's Q1 2025 earnings call last week Musk promised that he’d be “allocating far more” of his time to Tesla beginning in May adding that “the major work of establishing the Department of Government Efficiency is done.” Despite Tesla's top executives refuting the details of the Journal's report Wall Street analysts point out that this is an example of how Musk and Tesla are virtually inseparable In a note to investors published shortly after the WSJ report on April 30 UBS analysts led by Joseph Spak noted that the report showed how “perhaps no other company has as large a key man risk,” adding that “finding a CEO who can captivate the market and investors as much as Musk is a tall task.” Tesla Bull and Wedbush Securities analyst Daniel Ives wrote in a note to investors that while the WSJ report painted a “very tense situation” between Musk and the Tesla board he and other Wedbush analysts “believe Musk will remain CEO for at least five years at Tesla.” During an appearance on Bloomberg Surveillance on May 1 Ives denoted that Musk's “days at the White House are done” and that “Musk is Tesla and Tesla is Musk.” I feel that Tesla should be motivated to make miracles and focus on cars now that it is under the most powerful microscope whether it be the robotaxis or the lower-cost cars It's also been eight years since Tesla revealed the second-generation Roadster other established manufacturers are catching up to Tesla's coattails and if Musk and other Tesla executives aren't careful it won't be long before Tesla is no longer the sales leader LLC and respective content providers on this website Other product and company names shown may be trademarks of their respective owners LLC and respective content providers to this website may receive compensation for some links to products and services on this website Posted in: Games, Video Games | Tagged: Super Evil Megacorp, teenage mutant ninja turtles, Teenage Mutant Ninja Turtles: Splintered Fate, tmnt We now knjow when Teenage Mutant Ninja Turtles: Splintered Fate will arrive on Xbox and PlayStation Super Evil Megacorp revealed the official console release dates for Teenage Mutant Ninja Turtles: Splintered Fate PlayStation owners will get it first when the game arrives for their consoles on May 20 followed by the Xbox versiom coming on June 24 those who wish to go the extra mile can get the physical edition for multiple platforms on August 26 That one will come with reversible cover art pick your favorite Turtle and jump into a roguelike adventure to save Master Splinter from the foot clan unite in bodacious online and local co-op gameplay All progress made during the demo continues into the main game so you can pick back up straight where you left off In Teenage Mutant Ninja Turtles: Splintered Fate and team up with friends for bodacious co-op gameplay and -most importantly- Ninja to create unique and bodacious builds for your Turtles Every run brings new challenges and opportunities – explore and perfect your favorite builds and combine them with allies to conquer your enemies mysterious portals simultaneously appear across NYC With April and Metalhead analyzing recovered artifacts for clues as the gang gets ever closer to Splinter's otherworldly location an even greater threat lingers in the shadows… Please enter the email address you use for your account so we can send you a link to reset your password: Let’s play out what could happen as the House Ways and Means Committee does its work One of the most important fights over the Inflation Reduction Act’s survival has finally arrived It’s happening behind the closed doors of a powerful House committee in charge of tax policy The House Ways and Means Committee is writing its version of Republicans’ budget reconciliation bill, the centerpiece of President Donald Trump’s legislative agenda. The committee could release that text as soon as mid-May And other than a few broad outlines — the text will extend Trump’s tax cuts for the wealthy and it will increase the deficit by no more than $2.8 trillion — nobody has any idea what it will say will give us the first real sense of how likely the Inflation Reduction Act’s tax credits are to survive in the Trump tax bill After months of speculation and tea leaf-reading the House Ways and Means Committee’s draft will represent an opening position of sorts for Republican leadership — and illustrate just how close to repeal the majority is willing to get The committee could take a scorched-earth approach cutting essentially every IRA tax credit in order to force members to fight to get policies back into the final bill Or it could reform some tax credits so significantly that it effectively repeals the IRA It could also reform some credits — such as the electric vehicle and clean electricity tax credits — while leaving most others untouched The most important suggestion of what will be in the final version came on Thursday in a new letter addressed to Jason Smith The letter demands the IRA’s full repeal — essentially heralding a potential new “anti-IRA” caucus within the GOP “We are deeply concerned that President Trump’s commitment to restoring American energy dominance and ending what he calls the ’‘green new scam’ is being undermined by parochial interests and short-sighted political calculations,” the letter says The letter writers focus their ire on subsidies for “wind and biofuel[s] … carbon capture and hydrogen … [and] solar and electric vehicles” that they say form the backbone of the bill So far, House Republicans have largely written letters about the IRA to call for its preservation. Last summer, 18 House Republicans wrote to Speaker of the House Mike Johnson to ask him to move gingerly around any “repeal or reform” of the tax credits should Republicans win the November election “We must reverse the policies which refine American families while protecting and refining those that are making our country more energy independent and America more energy secure,” the letter said Since then, the number of pro-IRA voices in the GOP has risen. Last month, 21 House Republicans wrote to Johnson again in support of the law advising that any reforms proceed in a “targeted and pragmatic fashion.” They did oppose “premature credit phase outs” or restrictions on transferability Speaking earlier this week at a Semafor event the Illinois Republican and Ways and Means member Darin LaHood imagined phasing out some of the energy tax credits earlier “The approach we’'re looking at now is how you have an appropriate ramp-down [of IRA tax credits] that allows for businesses and companies to continue to be active in this space, but also saves money," LaHood said He added that there is a “bullseye” on the clean energy law and said that “we’ll see” whether any of its provisions are preserved this legislative vehicle will likely determine the fate of the IRA’s energy tax credits and other climate spending and some Republicans believe that its tax credits should be repealed to pay for their tax cuts for wealthy earners which means the Ways and Means Committee is where the IRA could go to die That’s because it oversees tax policy — and therefore manages the IRA’s all-important tax credits The committee also has a spending problem. The legislative process Republicans have chosen to pass their budget bill, known as reconciliation, begins with establishing binding spending limits for committees in both the House and the Senate. That process wrapped up last month Under the guidelines passed by the House earlier this year, the Ways and Means Committee can expand the deficit by as much as $4.5 trillion. But simply extending the 2017 tax cuts’ expiring provisions will cost $4.4 trillion — and the committee wants to do more besides including expanding the deductions that people can claim for their local and state taxes The committee will struggle to pay for everything it wants to do — and it could look to repealing parts of the IRA to fix it It doesn’t help that Representative Jason Smith of Missouri, the Ways and Means chairman, has called the IRA “welfare for the wealthy and well-connected.” The committee’s conservative bent — and the fact that GOP lawmakers broadly want to stay on track to pass a bill by the end of the summer — mean that the IRA tax cuts are especially vulnerable during this period Most of the IRA’s tax credits are due to sunset in 2032 But one measure — a technology-neutral credit to support new clean electricity generation — could run for much longer than that That also makes it among the most expensive policies in the law. When Republicans talk about ending tax credits early, the tech-neutral tax credit is an obvious target. Two lawmakers from North Dakota — Representative Julie Fedorchak and Senator Kevin Cramer — are working on language to phase out some tax credits in five years, Axios Pro has reported But ending the credit by then could reshape what kind of energy technologies the law supports Republicans tend not to see all zero-carbon electricity equally — while they often champion nuclear and advanced geothermal generation many look less favorably on wind and solar power But by terminating the tech-neutral tax credit at the end of the decade Republicans could help essentially the very technologies they don’t want There are no new nuclear or geothermal projects in the development pipeline across the country and new ones are unlikely to crop up until the late 2020s at the earliest energy projects must be “placed in service” by the time a tax credit expires meaning that virtually no new nuclear or geothermal projects could qualify New nuclear projects will face especially serious trouble if the Trump administration guts the Department of Energy’s in-house bank Other Republicans have suggested terminating the law’s transferability clause companies can sell their tax credits to other firms that can better use the subsidy that reform could hurt the IRA by reducing the value of its tax credits because companies will have to adopt more complicated financial structures in order to claim a given subsidy solar and wind developers have more experience adopting these arcane structures than the nuclear or geothermal industries which have fewer projects under their belt Republican Senator John Curtis of Utah said he was still hopeful that the IRA would survive without significant cuts “I don’t think that makes it through the House,” he said when asked if the Ways and Means Committee could slash the IRA tax credits outright “There’s a lot of insecurities in the Republican Party about not cutting and about where the boundaries are.” We’ll have a much better sense of where those boundaries are soon Editor’s note: Updates to reflect Ways and Means delaying its markup Robinson Meyer The fundamentals are the same — it’s the tone that’s changed At some point in the past month, the hydrogen fuel cell developer Plug Power updated its website Beneath a carousel explaining the hydrogen ecosystem and solutions for transporting fuel the company’s home page now contains a section titled “Hydrogen at Work.” reliable power while reducing reliance on imported fuels,” the text in this new box reads “Plug’s hydrogen and fuel cell solutions strengthen the energy grid and enhance national security as a leader in the global energy transition.” It is fairly ordinary website copy, but to a keen reader, the text jumps out as an obvious Trump 2.0 tell. Plug Power — like many green economy companies — has pivoted to meet the political and economic moment, where “energy independence” and “energy dominance” are in and “climate” and “sustainability” are out “I am actually shocked every time I look at the website of a climate tech company that still uses the language from 12 months ago from four months ago — that doesn’t do them any good,” Peter Atanasoff the managing director and vice president of Scratch Media and Marketing which helps B2B technology companies and climate tech businesses achieve growth and recognition The shift in language is more significant than just brands chasing the latest buzzwords “The real trigger” for resulting differences in branding between the first and second Trump administrations has been “the change of tone and change of economic policy,” Atanasoff told me “It is explicit opposition to any of these technologies." Lobbyists and clean energy companies that want to be in the administration’s good graces have adapted That has changed the tenor of green business at large office of Browning Environmental Communications told me over email that tweaking brand language is “typical after any change of administration particularly when there are significant shifts in policy.” But especially for organizations in the public eye “it’s more important than ever to highlight the historic and potential economic benefits of environmental solutions — and show how they are supported by the president of the management consulting service Green Strategies and the chairman of the White House Climate Change Task Force under President Bill Clinton “It’s what I refer to as climate capitalism which is the realization that by incorporating climate change and its risks and opportunities into your business strategy you’re actually going to be a more successful Companies are attempting to match the frequency of the administration and the broader policy ecosystem — a frequency that tends to be aggressive and heavy on words like “dominance” and “security.” It might also take the form of decreasing the volume at which companies had previously shouted their climate bona fides the senior vice president of public relations at Scratch M+M said her team has also advised touting “American-made production” in brand messaging and reframing copy to focus on “the positive impacts and immediate business benefits” of the companies rather than more idealistic messaging about climate goals that may have had stronger resonance during the Biden administration and at a time when even the word “green” can give you a black mark dismissed reading too much into how language itself changes under President Trump “If yesterday a new technology company was touting itself as a climate solution and now it’s touting itself as a way to achieve energy dominance — I don’t care,” he said “Good business remains good business,” Ballentine went on It might sound like branding agencies are encouraging companies to “play along” with the administration but Nelson of Scratch M+M stressed that wasn’t what she was trying to say “To be a thriving company that is going to change the world you need to make sure you don’t go out of business.” The message might be more accurately summarized as “read the room.” A report from Heatmap’s San Francisco Climate Week event with Tom Steyer Climate Tech's Next Winners.Sean Vranizan Tom Steyer and Robinson Meyer.Sean Vranizan Sam D'Amico and Nico Lauricella.Sean Vranizan Impulse's high-power Cooktop on display at the event.Sean Vranizan All three panelists acknowledged that it’s a delicate time for clean tech investors and companies alike “Volatility and uncertainty are the enemies of running and planning a business,” warned Kra The true cost of the tariffs is therefore extremely high Kolster agreed that things are generally gloomy in the investment space but also highlighted the technologies that are currently thriving in the past few weeks.” The companies and technologies she’s excited about faster,” as Steyer pointed out earlier in the evening Swaminathan added that there will always be a certain element of risk when it comes to investing in emerging technologies “Clean tech companies have so many single points of failure,” he said “And you have to prop up each part with the right leadership team You have to have strong pillars so that [your company] doesn’t break.” Guests following the discussion.Sean Vranizan leading to a potentially wet Kentucky Derby on Saturday at Churchill Downs The House Natural Resources Committee released its portion of Republicans’ budget package on Thursday evening. The proposal goes to markup next week but includes several significant measures across its 96 pages The BLM additionally released a draft environmental review of a separate solar project “The fact BLM is willing to admit other solar projects could advance later on is significant after the sputtering seen in the earliest days of the Trump administration.” Her caveat is that it’s unclear if this means solar permitting is a beneficiary of the president’s “energy dominance” agenda a news cycle or disgruntled legislator could steal the president’s ear and make him angry at solar power.” in 2024 after Hurricane Milton.Joe Raedle/Getty Images The major reinsurance company Swiss Re has released a lengthy report about the upward trend of insured losses in the United States Read more of Swiss Re’s findings in the report here The Trump administration has ordered the National Science Foundation to stop awarding new grants or supplying funds for existing grants “until further notice,” according to an email reviewed by Nature NSF leadership had recently directed its staffers to return grant proposals concerning “topics or activities” not “in alignment with agency priorities” to their applicants including funding the first major ice core drilling project in Greenland in 1980 to study historical carbon dioxide data using advanced climate modeling to predict extreme weather events better.