Please select what you would like included for printing: Copy the text below and then paste that into your favorite email application a daughter of the late Charles and Mariann (Popoli) Cahill and spent her early years in Pittsburgh Arizona where she lived for thirty-five years working as a medical assistant She was the wife of the late Thomas Sarnowski and the mother of the late Scott Stowitzky.  A move to Waltham ten years ago afforded her the opportunity to be close to her sister Debbie worked for Our Lady’s After-School Program with the pre-school children which she enjoyed very much Debbie was affable and friendly and had a special talent with arts She loved listening to music and watching movies She could tell you any actor in any movie or TV show you would mention She could set records solving puzzles and could easily work several cards at once at area BINGO games Debbie also had an affinity for animals of all types Micco (Elizabeth ‘Dolly’ Doherty) of Waltham; her nieces and nephews Michelle Barra (Chris) and Shaun Maloof (Michelle) and several grandnieces and grandnephews Family and friends will honor and remember Debbie’s life by gathering for an Evening Wake on Friday Memorial donations may be made to Kindness Animal Hospital Enter your phone number above to have directions sent via text This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply Service map data © OpenStreetMap contributors Each day, the team at Aircraft For Sale picks an airplane that catches our attention because it is unique, represents a good deal, or has other interesting qualities. You can read Aircraft For Sale: Today’s Top Pick at FLYINGMag.com daily Today’s Top Pick is a 2000 Micco SP20 Aircraft designer Al Meyers is renowned for building the Meyers 200 a legendary four-seat retractable that debuted in the mid-1950s with looks and performance that would dazzle the aviation community for decades to come The 200 evolved from a smaller Meyers model called the MAC-145 a two-seater that set a number of speed records for its category The Micco SP20 for sale here essentially is a remake of the MAC-14 While the Micco SP20 makes an excellent traveling aircraft for two people who want to reach destinations quickly it was developed in part with pure enjoyment in mind For pilots who feel the aviation industry has focused too intensely on moving efficiently between points A and B the notion of flying strictly for fun can be especially appealing Those with less-specific travel plans who are more interested in chasing good times are among the target audience for the Micco SP20 For those seeking even livelier performance with more aerobatic capability a 260 hp evolution of the earlier aircraft Pilots looking for a light, speedy two-seat retractable aircraft with an interesting lineage that provides impressive, economical performance should consider this 2000 Micco SP20, which is available for $94,500 on AircraftForSale. If you’re interested in financing, you can do so with FLYING Finance. Use its airplane loan calculator to calculate your estimated monthly payments. Or, to speak with an aviation finance specialist, visit flyingfinance.com Home » Home » HURRICANE MILTON UPDATE: Brevard County Shelters Now Open for the Public in Cocoa By  //  October 9 FLORIDA – Brevard County will open three shelters at 9 a.m for residents who live in manufactured or mobile homes or those needing safe harbor from potentially dangerous wind and rain conditions anticipated from Hurricane Milton which is expected to begin impacting the county sometime late Wednesday and continuing throughout the day Thursday A Hurricane Warning is now in efffect for Brevard County – a Hurricane Warning means hurricane-force winds are expected somewhere within Space Coast within the next 36 hours Shelters that will be available for general population and families wishing to bring their pets includes: Space Coast Area Transit will provide transportation to the shelters for those with special needs Residents going to shelters will need to take their own supplies or sleeping bags; any needed medications; multiple changes of clothing and and sturdy shoes; personal hygiene items; and entertainment items bring a supply of nonperishable food that will be sufficient for 3 days per person • All required medications and medical support equipment: • Any specific medications or care instructions ( 2-week supply) For more information about this and other Hurricane Milton questions call the Community Information Hotline at 2-1-1 WATCH: Live Hurricane Milton update and information with Sheriff Wayne Ivey and Emergency Management Director John Scott WATCH: Hurricane Milton report from Laurie Wilson Park in Cocoa Beach by The Friday Night Locker Room’s Orville Susong and Steve Wilson The latest forecast from the National Hurricane Center projects Brevard County could see 6 to 10 inches of rain Space Coast residents should have their final preparations for Hurricane Milton made by Tuesday FLORIDA – A Hurricane Warning is now in efffect for Brevard County – a Hurricane Warning means hurricane-force winds are expected somewhere within Space Coast within the next 36 hours A Local State of Emergency is in effect for Brevard County in response to the pending threat of Hurricane Milton which is now a Category 4 hurricane slowly churning toward the west coast of Florida with a projected impact as a Category 1 hurricane in Brevard County starting Wednesday about 10 p.m Brevard County is currently under a hurricane watch Space Coast residents should have their final preparations for Hurricane Milton made by Tuesday, longtime Central Florida Meteorologist and Space Coast Daily correspondent Danny Treanor offers some sage advice and reminders on how to prepare for a storm. CLICK HERE TO WACH FLORIDA – In anticipation of the potential impacts from Hurricane Milton Brevard County will offer free sandbags for residents beginning 8 a.m Sand is being provided by Brevard County Public Works and the Brevard County Sheriff’s Office will have supervised inmate work crews filling and loading sandbags for residents bags are provided and filled by on-site personnel There is a limit of 10 sandbags per vehicle WATCH: Update from sandbag distribution location at Eastern Florida State College’s Palm Bay campus in preparation for Hurricane Milton WATCH: Space Coast Daily’s Zach Clark is live from Mitchell Ellington Park in Merritt Island as Brevard Public Works Provides Free Sandbags Today in preparation of Hurricane Milton Click Here to Sign Up for Text Alerts Metrics details Senescent cells accumulate in various ageing-associated diseases Numerous studies using genetically engineered mouse models or chemical inhibitors that target pathways induced in senescent cells have indicated that the clearance of senescent cells can alleviate some of these diseases and promote healthy ageing proposed a therapeutic approach for the removal of senescent cells that exploits the adaptive immune system by using chimeric antigen receptor (CAR)-T cell therapy further optimization of the CAR may be necessary to ensure maximal therapeutic efficacy while limiting potential side effects in a subset of myocytes and innate immune cells raising important concerns about the off-target effects of senolytic CAR-T cells on healthy tissues before this innovative therapy can be applied to the treatment of ageing-related diseases its efficacy and long-term responses must be confirmed in humans particularly in older individuals with compromised immune systems Prices may be subject to local taxes which are calculated during checkout Senolytic CAR T cells reverse senescence-associated pathologies Prophylactic and long-lasting efficacy of senolytic CAR T cells against age-related metabolic dysfunction p16-dependent increase of PD-L1 stability regulates immunosurveillance of senescent cells Download references University School for Advanced Studies IUSS San Raffaele Telethon Institute for Gene Therapy (SR-TIGET) Reprints and permissions Download citation DOI: https://doi.org/10.1038/s41580-024-00792-2 Anyone you share the following link with will be able to read this content: a shareable link is not currently available for this article Sign up for the Nature Briefing newsletter — what matters in science Hi a you tell me What’s going on with Samara Kokinos Mar 31, 202501MiccoJulie BroughtonApr 1 She is taking some time off and will be back at the end of May moreLog in to CommentBACK TO TOPTV Listings Email Newsletters RSS Feeds Contests and Rules Contact Us / Follow on Social Media Careers at WKMG Closed Captioning / Audio Description Public File Current EEO Report Terms of Use Privacy Policy Do Not Sell My Info FCC Applications EEO Report Disability Assistance Copyright © 2025 ClickOrlando.com is managed by Graham Digital and published by Graham Media Group, a division of Graham Holdings. Volume 9 - 2022 | https://doi.org/10.3389/fmed.2022.1011206 This article is part of the Research TopicVascular Malformations and ThrombosisView all 14 articles Internal jugular agenesis is a vascular malformation that is often associated with a history of recurrent headache Due to the resulting abnormalities in intracranial venous drainage it may be complicated by neurological dysfunction and neurodegenerative diseases such as multiple sclerosis The simultaneous presence of jugular vein agenesis and thrombosis is possible in cases of acute illness or venous drainage abnormalities (VDA) (e.g. the literature still lacks data on thromboprophylaxis in pregnant women with jugular vein agenesis we report a positive experience with prophylaxis using enoxaparin during pregnancy in a patient with internal jugular agenesis The internal jugular vein is crucial for the drainage of intracranial veins (1). The literature contains numerous reports of venous drainage abnormalities (1–3) each of which is associated with the possibility of increased intracranial venous pressure and with relevant symptoms and signs such as headache as well as with neurodegenerative diseases (e.g. or other types of vascular malformation associated with prothrombotic conditions such as pregnancy may increase the risk of venous thrombosis data concerning the association of venous malformation with venous thrombosis in pregnancy are lacking in the literature We may postulate that internal jugular vein agenesis may be associated with an increased risk of developing venous thromboembolism (VTE) in the context of additional prothrombotic risk factors such as pregnancy. An association between venous malformation and venous thrombosis in the presence of other prothrombotic conditions such as those reported above has, in fact, already been found in May-Thurner syndrome and vena cava agenesis (4, 5) we report an intriguing case of internal jugular vein agenesis in a pregnant young woman with a history of recurrent headache who underwent successful thromboprophylaxis treatment throughout her pregnancy A differential diagnosis was made because of a positive history of recurrent miscarriage (Table 2) (8) Mild thrombophilia due to the predisposition to develop hyperhomocysteinemia (caused by the MTHFR 677 TT genotype) was the only detectable risk factor for recurrent miscarriage (defined as three spontaneous abortions during the first trimester of pregnancy without a detectable cause) Differential diagnosis performed by the patient for recurrent miscarriages An elicitation of personal history to evaluate the presence of the unusual varicose vein did not reveal any previous surgical approaches or the recent positioning of venous lines that could explain its development no acute or chronic medical illness or acute infection was detected the probability of detecting an internal jugular vein thrombosis was considered low and pharmacological antiplatelet treatment with 100 mg daily aspirin was confirmed The patient underwent a blood count and homocysteine check every month as well as obstetric follow-up to prevent intrauterine growth retardation (IUGR) However, 3 weeks after the first clinical evaluation, the patient was referred for an increase in the volume of the varicose vein in the neck, associated with cough (Figure 1) An color Doppler ultrasound examination was then scheduled and performed after a few hours Collateral variceal venous circulation of the neck due to the presence of internal jugular agenesis Magnetic resonance imaging with evidence of internal jugular agenesis Given the risk of jugular vein thrombosis, the use of a different method of thromboprophylaxis was considered. No guidelines are available in the literature, in fact, to suggest the proper approach in this clinical context, even though an increased thrombotic risk during pregnancy has been found for other venous malformations, such as May-Thurner syndrome and vena cava agenesis (4, 5) Our patient had several contemporaneous (if mild) thrombotic risk factors: a history of recurrent miscarriage ongoing pregnancy and the associated hormonal treatment (although progesterone is less prothrombotic than other hormonal treatments) we stopped the administration of aspirin and we suggested starting a pharmacologic thromboprophylaxis with enoxaparin 40 mg daily until childbirth to prevent the onset of venous thrombosis and also to prevent possible miscarriage Given the patient's atypical condition periodic clinical and instrumental monitoring was planned consisting of a monthly ultrasound of the veins of the leg and neck and an obstetric ultrasound to monitor uterine vascular pressure and gestational growth and activated partial thromboplastin time were also evaluated monthly (coagulation parameters and platelet count are often monitored during long-term prophylaxis with enoxaparin particularly for pregnant women or patients with kidney failure because of the modification of the half-life of low-molecular-weight heparin in these contexts) No vascular complications were detected during the remainder of the pregnancy The patient delivered a live-birth baby (weighing 3.0 kg) via cesarean section Enoxaparin was prolonged for 4 weeks after delivery because of the surgical approach; the patient was then dismissed from our practice Written informed consent was obtained from the patient to describe her clinical picture Low-molecular-weight heparin is most commonly recommended for the prevention of venous thromboembolism in pregnancy (19). In contrast, there is no indication for direct oral anticoagulant therapy (20) during the gestational months, while low-dose aspirin prophylaxis (81 mg/day) is recommended only for women at high risk of pre-eclampsia and should be initiated between 12 and 28 weeks of gestation (25) We reported a singular case of a pregnant woman with a rare vascular malformation and a risk of developing venous thrombosis This anatomical venous malformation is only rarely described in case reports and has not yet featured in randomized clinical trials Because the patient was at risk of developing thrombotic complications we performed a thorough clinical evaluation of all clinical conditions and risk factors that may favor the adoption of a prolonged pharmacological thromboprophylaxis As we await larger clinical trials to confirm the validity of this method we hope that our precautional medical approach can be of use in similar cases The raw data supporting the conclusions of this article will be made available by the authors Ethical review and approval was not required for the study on human participants in accordance with the local legislation and institutional requirements The patients/participants provided their written informed consent to participate in this study All authors contributed to the article and approved the submitted version The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher Surgical review of the anatomical variations of the internal jugular vein: an update for head and neck surgeons Ultrasonic imaging of the internal jugular vein PubMed Abstract | CrossRef Full Text | Google Scholar Anatomic variations of internal jugular vein inferior petrosal sinus and its confluence pattern: Implications in inferior petrosal sinus catheterization May-Thurner syndrome: History of understanding and need for defining population prevalence Inferior vena cava agenesis in patients with lower limb deep vein thrombosis in the RIETE registry When and why to suspect NICE recommends progesterone to prevent early miscarriage PubMed Abstract | CrossRef Full Text | Google Scholar Association between gene polymorphism of folate metabolism and recurrent spontaneous abortion in Asia: A Meta-analysis ESHRE Early Pregnancy Guideline Development Group Google Scholar Developmental venous anomalies (DVA): the so-called venous angioma Spontaneous hemorrhage from a cerebral venous malformation related to thrombosis of the central draining vein: demonstration with angiography and serial MR PubMed Abstract | Google Scholar Spontaneous thrombosis of developmental venous anomaly (DVA) with venous infarct and acute cerebellar ataxia Paediatric presentation of intracranial haemorrhage due to thrombosis of a developmental venous anomaly Thrombosis of a drainage vein in developmental venous anomaly (DVA) leading venous infarction: a case report and review of the literature Symptomatic Infratentorial Thrombosed Developmental Venous Anomaly: Case Report and Review of the Literature Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination VITT COVID-19 and the Expert Haematology Panel: The story of how the UK responded to emerging cases of vaccine-induced immune thrombocytopenia and thrombosis during the vaccination programme COVID-19-Associated Cerebral Developmental Venous Anomaly Thrombosis With Hemorrhagic Transformation Diagnosis and Management of VTE in Pregnancy PubMed Abstract | CrossRef Full Text | Google Scholar and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) Deep venous thrombosis in pregnancy: incidence Cerebral venous thrombosis associated with pregnancy and puerperium Hormones and pregnancy: thromboembolic risks for women PubMed Abstract | CrossRef Full Text | Google Scholar D-dimer and protein S in uncomplicated pregnancy 743: Low-dose aspirin use during pregnancy PubMed Abstract | CrossRef Full Text | Google Scholar Cataldo D and Imbalzano E (2022) Case report: Successful thromboprophylaxis with enoxaparin in a pregnant woman with internal jugular vein agenesis Received: 03 August 2022; Accepted: 31 October 2022; Published: 22 November 2022 Copyright © 2022 Di Micco, Orlando, Cataldo and Imbalzano. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Pierpaolo Di Micco, cGRpbWljY29AbGliZXJvLml0 Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish This website is using a security service to protect itself from online attacks The action you just performed triggered the security solution There are several actions that could trigger this block including submitting a certain word or phrase You can email the site owner to let them know you were blocked Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page Home » Home » WEATHER ALERT: Special Weather Statement Issued for Malabar By  //  May 19 FLORIDA – The National Weather Service announced a special weather statement has been issued for Sebastian One-half inch sized hail is expected with the storm Christy-Smith Funeral Homes - Larkin Chapel A talented cellist whose diverse musical influences ranged from classical (Yo-Yo Ma) to rock (Arctic Monkeys and Red Hot Chili Peppers) to hip hop (Immortal Technique and Dilated Peoples) rising second-year music student Micco Daniels passed away recently Micco began studying the cello in middle school after a class assignment introduced him to the work of Yo-Yo Ma.  Wallace realized his son had musical aptitude at a young age and encouraged him often to pursue his passion “It was obvious how happy Micco was when he was playing cello,” he said and planned to study Russian with his sister They also had an interest in learning Tagalog as part of their Filipino heritage A 2019 graduate of Mount Vernon High School in Alexandria Daniels was introduced to Case Western Reserve University by his high school orchestra director “It was the greatest honor of my career when he told me he had chosen to follow in my footsteps at CWRU,” Rodriguez shared He describes Micco as “a brilliant student wisdom and kindness to everyone he touched Faculty members and friends from Case Western Reserve University and the Cleveland Institute of Music remember Daniels as a talented musician with a calming presence and good sense of humor “Micco felt like a longtime friend from our very first conversation,” said Elizabeth Javorsky a rising second-year music and international studies student “He was always genuine and accepting and made you feel comfortable being yourself.” director of orchestras and music education professor at Case Western Reserve Even though he was only here for a short time he left an indelible impression on all of us May we take it and honor him by giving it to someone else.” Wallace Daniels is grateful his son chose Case Western Reserve and hopes to find a way to remember his son at the university “Micco really blossomed during his time on campus,” he said “He found like-minded friends and enjoyed the local arts community.  Usually kids look up to their father,” Wallace said The Daily will share information about memorial services should details become available.  Students who would like support during this time are encouraged to contact counseling services at 216.368.5872 This line is staffed by a counselor 24 hours a day Faculty and staff can access counseling at any time by calling IMPACT Solutions at 1.800.227.6007; you can learn more about their programs at myimpactsolution.com Interested in participating in a research study Looking for an upcoming event in your department Subscribe to The Daily Items that appear in the Community Postings section are submitted by visitors Posts are reviewed to ensure they are appropriate for our audience but typically are not edited by University Marketing and Communications Case Western Reserve University is committed to academic freedom and promoting diversity of thought The views of those who speak on our campus do not necessarily reflect the views of the university administration or any other segment of the university community In her essay “Why Read a Poem in a Time Like This?”, Marilyn McEntyre writes: We need it because good poems do something prose can’t do They invite and enable us to notice the precarious fissures in what we think is solid ground They direct us toward the light at the edge of things — the horizon and can only be accurately captured by metaphor They take us to the edge of “what can’t be said,” and ambush us into feeling before we think so that we can’t simply and complacently “believe everything we think.” Poetry deals in surprise and subversion and turns old words to new purposes Marilyn is joined by Guy Micco to talk about why poetry is important in general why it’s important in medical or nursing education and why it’s important for people who care for older adults how they unlock dimensions and emotions that are otherwise locked away How sometimes good poetry can be like a needed punch we convince that poetry skeptic Eric Widera that there is a place for poetry in medicine after all we’re going to be talking about poems today I’ve been after Eric to do this podcast for years So we are delighted today to welcome Marilyn McEntyre who’s a longtime teacher of literature and medical humanities including one that’s probably most relevant to today I think it’s titled Patient Poets Illness Marilyn: Patient Poets: Illness From Inside Out Alex: Patient Poets: Illness From Inside Out She also teaches people who are interested in writing their own books titled Why Read a Poem at a Time Like This And we’ll try to include links to that in our show notes depending on whether you’re in Italy or in America Who is a long time teacher in the joint medical program Joint medical program is between UC Berkeley and UCSF I was a medical student there some 25 years ago or so Those were great days and he is no longer growing old He’s also a part-time hospice and palliative care clinician And he’s at a long time interest in medical humanities since you have been a longstanding mentor for Alex and teacher I think you are going to supersede Alex here and actually do a song for us It was released on his first album in 1971 But I’ve been told that he wrote this as a teenager And he just died a couple years ago of COVID I’m amazed that a young man could put himself into the place of an old man in such a poignant way It’s you can just see his story unfolding in a way that makes you realize John Prine knew something about aging And he would talk with people there as he delivered the paper on the paper route And they’d sometimes think he was their son or a relative and they’d have conversations but he’s just an amazing songwriter to be able to do something like that it reminds me of a time when I was a young physician and could have used this song in my mind when I went into nursing homes to care for people And I saw them lined up in their wheelchairs along the corridors and too many nursing homes are still like this but people would be lined up sitting on often strapped into their wheelchair And I’m reminded of Bill Thomas’ Eden Alternative places where people are over medicated and undertreated for these three plagues Eric: Likely have gotten a lot worse in the last two years Alex: We could unpack that song for the next hour but we do need to move on to topic of today Tell me how you got interested and/or when I lived in a three generation family and my grandmother was an English teacher and my mother was a teacher and everybody read And so poetry was just part of the family discourse People would come up with lines from things It felt as though there was this big trove of words that we could pull up when we needed them like having a big bowl of candy in the middle of the table Eric: How about in particular around this theme of aging in poetry I’m trying to think about when I first connected them But years ago when I started to be interested in medical humanities medicine was always a road not taken for me I really felt as though one of the things I might want to do is be a doctor And for various reasons I didn’t do that And so I was really happy when I found a way to come into medicine through the back door And I do think that writing isn’t always And that poetry has helped in the process of both psychological and even sometimes physical healing Marilyn: I was teaching TS Elliott’s Four Quartets at Mills College one year And I started a class in poetry by just asking this big group of young women Which is a question I like to pose myself and others Then immediately a hand went up in the back “Poetry saved my life.” And she was dead serious about that But I think have had many real world encounters with people who feel like that That there’s a particular passage from a poem or a particular image or way of putting something that has given them a way of imagining their way back into health or sanity or peace Guy: I probably came to it because in my youth because I liked the kind of poetry that’s sort of smarty pants Which I think is the particular ability that poetry has that transcends in a way prose there are prose pieces that are like poetry Guy: There are prose poems where you suddenly have an insight that knocks you over a little bit Doesn’t have to be a great a lightning strike I get it.” I see an opening of the some sort I’m sure there are other words for that Marilyn can describe it opens up what I imagine could be called the empathic imagination Like you get to see what it’s like to be someone else in the case of medicine someone else who’s suffering in a way that transcends the biological Our bio pathology is the forte of medicine you may remember was a… He died recently Alex: I think it was either Columbia or Cornell when there’s a problem with your heart you don’t get to just take it to the heart mechanic and leave it off and go away.” Unfortunately there’s a person attached to the heart it’s incumbent upon you to understand that that’s got a bad rhythm or that’s impacted there’s a person with all the other bio I just want to read something that Marilyn you wrote It recalls us to contemplation in a world of action go back and reconsider what we thought we saw or knew the first time.” I love that That was in an essay that Steve McPhee wrote about his experiences with patients and reading poetry to patients which maybe we’ll talk more about later I was going to start with Shakespeare’s Son at 73 But actually when you asked about why poetry and I was thinking about how certain lines come back to you And I thought I would read you just a little part of Robert Frost’s well known poem Because the whole poem is really about picking apples in the fall in New England but it’s also about many other things And here are the lines that have come to me when I think about these transitions into the next season of life He’s talking about the load on load of apples coming in “For I have had too much of apple picking I am over tired of the great harvest I myself desired There were ten thousand thousand fruits to touch No matter if not bruised or spiked with stubble went surely to the cider-apple heap One can see what will trouble this sleep of mine Marilyn: And then the poem goes on from there “I am over tired of the great harvest I myself desired.” So precisely talks about a moment when you think I’m done I’m done with this thing that I’ve done with so much energy for so many years “There were ten thousand thousand fruit to touch lift down and not let fall.” And I thought about all of the student that have gone through my office hours for decades and trying to cherish each one of them But there’s a time when you reclaim something of your life and you leave a lot of that ministering to other people And so I think that moment of transition is just beautifully captured in that poem Marilyn: What I wanted to say about the sonnet it’s the first four lines offer one image of aging The next four lines offer a different image “That time of year thou mayst in me behold bare ruin’d choirs where late the sweet birds sang In me thou see’st the twilight of such day as after sunset fadeth in the west which by and by black night doth take away death’s second self that seals up all in rest thou see’st the glowing of such fire that on the ashes of his youth doth lie as the death-bed Marilyn: And so all it is really is a little reflection on this is what he’s speaking clearly to a younger person This is to be entering the last season of life in me when yellow leaves or none or few do hang And it isn’t… The logic is yellow leaves or few or none So there’s a little flickering of humor or even pleasure in this poem And that makes me think of a lovely essay by the poet Howard Nemerov on this similarity between poems and jokes He says that a good poem always has something akin to a punchline where it surprises you into reframing something and seeing it in a new way But even just what this poem does in trying out three different images of age is an invitation to say Marilyn: Is it like a river that’s dwindling to a stream Or is it like a tornado that’s coming down the path Or just trying out images for that can get at different dimensions of the experience And that’s what I love about this poem Personal reflections as you were reading the Robert Frost poem there’s so many patients I’ve seen And you can just think about them as this… Often in medicine these days we’re come to think of our work But then when you think about each one and their individual selves and how some are bruised some are broken and what we do with them and how we can take the time to cherish each one and for what it is And I love the image of uncertainty there with the and the work that we’ve done in thinking about prognosis and how uncertain that is though we make great efforts to try and quantify it we hear it a little bit of potentially what makes a good poem I think it’s that punch that Marilyn spoke of that maybe I spoke of it too A little insight that happens in such a short period of time there are two words you can use for poetry like Shakespeare’s sonnet or Hello in There And on reading it there are two… I don’t know Marilyn’s so much more adept at this than I am but it gives me a little view that maybe will last into another encounter with another person perhaps Guy: And sometimes the other kind of poem is one that is at least at first barely scrutable like TS Elliott’s Quartets and really dig and take some close reading to come to some better understanding And then there’s some that are just obscure It’s just obscurantism to the max that I can’t stand it before we started about a poem that we didn’t like – one of the greatest American poets who died recently Guy: I just don’t understand any of his poetry And I’m not… I don’t have the patience to dig but I find it worth digging to come to an understanding of what he’s trying to tell us but I don’t get it right away necessarily when we think about kind of the favorite aging theme poems what came to mind and can you give us an example It doesn’t have to be there and often it isn’t I’ll try to read it relatively quickly and you can make it available to people It’s called Jane by a fine poet by the name of George Bilgere is lugging big black trash bags to the curb It’s snowing hard and the bags are turning white Jane is getting ready to put her house on the market and move into a home of some sort She’s just too old to keep the place going anymore I’m thinking I’m so glad this isn’t going to happen to me Guy: It seems like a terrible fate to drag out your trash bags and then head for a facility somewhere that’s the whole reason you go there in the first place as I continue my morning walk around the block is that I’m not going to a facility of any sort I have enjoying life taking my morning walk just like this one and on and on ad infinitum I have no intention of doing so what Jane is doing grow old taking out her ominous black trash bags to vanish terribly in the snow getting ready for someone to drive her to the facility This is for the people like us who think the people we’re caring for don’t have anything to do with us We just act like it and Bilgere’s making it explicit I use this… I hate to say I use poetry But I like to read this in nursing facility with the administrators So that’s the first poem that actually came to mind when asked about poetry and aging even though it isn’t necessarily the best I’m going to read another piece from your essay This is Steve McPhee incorporated a number of these quotes into his essay so that a world of flat surfaces becomes charged with meaning is connected.” And that speaks to me about the ways in which poetry connects you to a key going into a lock And it unlocks something which might have been inaccessible to you And whether that’s emotions that many of us in the health professions have packed away whether that’s ability to relate to our patients and their experiences moving beyond the othering of the person they are going to a facility The way it makes three dimensional surfaces out of two dimensional surfaces see if you have any reflections there and then if you have another poem for us I think that there’s a difference between what does a poem say and what does it do Is the much more into interesting question what I have learned to ask in classes and conversations about poetry is what does this poem invite you to do So it seems to me that there’s always an undertow in a good poem what you see will connect with something you just heard Repetition is one of the basic poetic devices And each time you see the word or the image it has a kind of… It acquires the density that makes it more interesting And I think a good poem can invite you to think in phrases rather than sentences where a lot of younger students don’t get immediately why a poet would end the line right in the middle of a sentence But there’s a tension between a phrase and a sentence Marilyn: Sentences do something all by themselves And there’s a chemistry of words sitting next to each other on the line where you get an effect before you get a whole statement And so I think poetry gets us to that level of language that is at its deepest level is a kind of melody We communicate at the level of musical exchange And so I think poetry really helps us to be attentive to language in its subtler dimensions And sometimes there’s an exercise I would recommend to anybody which is take three sentences you’ve written that you like but something interesting is going to happen Marilyn: And I’m going to give you this really quick example because I tried it with the JMP students a few times write three sentences about an encounter with the patient Do anything you want.” Here’s what was interesting I had them all put their little poems on the board “I didn’t know what to say,” as the whole first line of the poem And another person broke the first line after Each one of those was a very different point of departure for entering into the rest of the thought of the poem Marilyn: So I think poems are inherently playful There’s a playfulness about poetry that seems to me to be at spiritual dimension you think of that is a kind of playfulness that just says So I can’t remember the rest of your question but I think we don’t have time for both It is a fortune beyond any deserving to be still here I consider a stick of cinnamon bound in raffia These days I speak less of death than the mysteries of survival And after surgery recognize each breath as a miracle We’d like to hold on stubbornly content even while aging.” One of my favorite phrases in that poem is So doing with JMP students and… How important do you think poetry is for the medical profession I think the easiest answer to why read a poem in a place like this which I talked about that at the medical program one time just like if you have a practice of meditation and I’ve heard doctors talk about this that you begin to listen for how people put things And for the metaphors that a patient will reach for to describe what they are experiencing and for the patterns of repetition and for the pleasure they take in retelling their story and how they put it together the language dimension of clinical work is it seems to me very much more fine tuned or refined Guy: We should have a cadre of poet physicians who couldn’t learn from the poets sensibilities Steve McPhee would read poetry with patients And that’s what this essay is about that I was exerting Marilyn’s quotes from Alex: And we should say Steve McPhee was a professor Wrote a textbook and among many other things helped start the comfort care suites at UCSF It can be presumptuous to pull out a poem and say… I mean I’m not saying Steve would do it this way for sure I just haven’t found that the opportunity where it’s really appropriate… I felt appropriate to me a couple of elder patients of mine who actually brought me the poems and she just loved this poem and wanted to share it Another was sent to me when I was very sick in the hospital by a patient of mine Occasionally Mary Oliver is too Mary Olivery for me tell me what will you do with this one wild and… One wild I think it’s really wonderful to be able to share poetry I have played music for patients or with patients do you have another poem that you could read to us before we get a little more John Prine “He opens the front door with the force of a minor hurricane which is held in only metaphorically by wide red suspenders He feels like a warm version of the north wind His cap is blue with a protruding bill and white letters proclaiming friends don’t let friends drive forwards But the last syllable lifting into a question under the red suspenders and orange tomcat grimaces on his T-shirt above the words He has left his truck’s motor running parked as far onto my lawn as the Oak tree will allow he says planning a wet mustache kiss on my mouth but I would make a pot of coffee for my brother because the world we knew together is coming to an end And he’s the only one who remembers the day I roller skated too far down the hill how he picked me up and called me by my childhood name Eric: I guess Guy out of all the poems that kind of go through It just came to mind as one poem that I have enjoyed in the past I used this poem in readers theater with students and elders Guy: So we’d go to a nursing facility and read with students and elders together and we’d split poetry or prose or whatever into parts for people to read together And this was one that I thought was particularly effective with students and elders reading up one part each dividing it up in various and certain ways there’s still a little of that kid in you You said at the beginning who like those zinger poems Friends don’t let friends drive forwards I think my only book of poems is on Shel Silverstein maybe I should branch out from my Shel Silverstein that maybe some of this… I see a thumbs up let’s hear a little bit more John Prine from Guy Very big thank you for joining us for this podcast thank you Archstone Foundation for your continued support and to all of our listeners “doing their own research.”  Self-identified… I read Farah Stockman’s article in the NYT on why… We invite the brightest minds in geriatrics, hospice, and palliative care to talk about the topics that you care most about, ranging from recently published research in the field to controversies that keep us up at night. You’ll laugh, learn and maybe sing along. Hosted by Eric Widera and Alex Smith. Learn more Republican challenger in NJ-9 didn’t see a path to victory Vince Micco has changed his mind and will not seek the Republican nomination for Congress in New Jersey’s 9th district against Rep “I’m not running anymore,” he told the New Jersey Globe “I don’t have a whole lot to say about it.” Micco entered the race last December after Pascrell won re-election by a closer-than-expected ten percentage points after redistricting made the 9th slightly more Republican But Micco raised just $18,933 during the first six months of this year and didn’t see a path to beat Pascrell in a presidential election year when voter turnout is more favorable to Democrats “I met with two consultants and I came away sour from running from two separate assessments of my viability,” he said Air Force veteran who took on Pascrell in 2020 and 2022 He’s raised $2,653 this year and has $637 cash-on-hand He spent $1,346 paying off a fine levied by the Federal Election Commission Among the challenges to Prempeh’s political prospects is a tendency to burn through cash  While raising over $310,914 for his 2022 race he spent much of that money on travel and overhead and a relatively small percentage of his warchest on voter persuasion Micco is not ready to make an endorsement in the race “No comment on prospective candidates,” said Micco Prempeh praised his would-be primary opponent “Vince Micco is an exceptional man and his military service speaks for him,” said “I really hope we can work together and tackle some of the biggest issues our constituents face here in NJ CD-9.” The 52-year-old North Arlington resident served two tours of duty in Iraq and continues to be an intelligence officer in the U.S This would have been Micco’s third bid for Congress: he challenged Rep Steve Rothman (D-Englewood) in the old 9th district in a heavily-Democratic district that gave 59% of the vote to John Kerry in 2004 and 61% to Barack Obama in 2008 After New Jersey lost a House seat in reapportionment after the 2010 census Pascrell defeated Rothman in the Democratic primary Prempeh held Pascrell to 55% last year; in 2020 before congressional redistricting made the 9th more competitive as a way of shoring up seats held by Reps Josh Gottheimer (D-Wyckoff) and Mikie Sherrill (D-Montclair) this was Pascrell’s closest race since he unseated Rep Bill Martini (R-Clifton) in 1996 with 51% of the vote Home » Home » Micco Road Bridge Over Sottile Canal Closed for Replacement By  //  January 31 FLORIDA – Micco Road will be closed to thru traffic for replacement of the existing bridge over the Sottile Canal located southwest of Barefoot Bay in south Brevard The road closure is expected to start on Wednesday lasting for a period of up to eight months all business and residential traffic will be detoured Informational signs on the closure will be in place and detours associated with this project will be conspicuously posted to alert drivers of the closed road Brevard County Public Works has worked proactively with Brevard County Fire Rescue and our other public safety partners to ensure emergency response time is not impacted we have worked with Brevard County Solid Waste Services Postal Service to minimize any impact to their regular operations Detour information: Between Babcock Street and US-1 the east-west route will become Grant Road to Old Dixie Highway to Shell Pit Road instead of Micco Road is a narrow two-lane bridge with no shoulder and has surpassed its life expectancy The replacement bridge includes two 11-foot travel lanes The new bridge will also meet current standards and provide a better experience for our residents and visitors The Brevard County Public Works department will be proactively working with the contractor to expeditiously complete the work and reopen the road sooner As the Lakes at Saint Sebastian subdivision is anticipated to be the most impacted by this closure we are working directly with the Homeowners Association to address any concerns Residents in this community may contact your HOA to submit inquiries Support local journalism. Unlock unlimited digital access to floridatoday.com Click here and subscribe today. When the airborne objects started striking his Micco manufactured home amid a fierce Sunday thunderstorm 86-year-old cancer patient Ray Choquet initially thought it was hail "Then I heard this big 'whoom!' I felt the house shake and I saw my screen porch and furniture were gone," Choquet recalled Monday standing amid puddles of water in his wrecked living room "I thought that was it — I didn't even know my roof had gone down the street," he said An EF0 tornado pummeled Choquet's home in River Grove Mobile Home Village scalping the roof and strewing heaps of wind-twisted metal debris across his yard Brevard County Fire Rescue spokesperson Don Walker said It appears 25 to 30 homes sustained damages More: Air Force Thunderbirds, A-10, Navy Growlers wow sun-splashed crowd at Cocoa Beach Air Show More: Avelo Airlines announces new nonstop flights from Melbourne airport to Conn., N.C. A three-person team from the National Weather Service station in Melbourne toured the Micco manufactured-housing park Monday morning documenting building damages and interviewing residents to determine whether a twister touched down confirmed that an EF0 tornado struck River Grove Mobile Home Village an age-restricted manufactured housing community stretching between U.S 1 and the Florida East Coast Railway tracks about ½-mile south of Micco Road The brief tornado touched down about 5:36 p.m near Cherish Court and Love Drive in the neighboring River Grove Mobile Home Village II just west of the railroad tracks Metal roofing material atop a couple of those homes got peeled into shapes resembling deformed tin cans the twister crossed the tracks and followed River Groves Drive leaving a ½-mile east-southeast path before crossing U.S 1 and emerging onto the Indian River Lagoon as a short-lived waterspout near Sebastian River Marina and Boatyard An eyewitness watched the tornado transition into a waterspout before dissipating and several boats got bumped from a storage rack at the marina Choquet said he does not have home insurance Plastic sheeting now covers his wet furniture I thought the house would twist over," Choquet said To hell with the furnishings," said Roberta Kwestel Most of the River Grove Mobile Home Village storm damages were confined to carports "We're seeing some damage to a couple properties in terms of their roofs we think that's because we lost part of the roof because it was connected to the carport or the front porch it kind of got tossed up into the air with it," Ulrich said standing on the River Grove Road asphalt during his storm survey Ulrich said the EF0 tornado also inflicted damages to the Summit Cove Condominiums just to the south of River Grove Mobile Home Village Maximum tornado width: 300 feet to 400 feet Walker said Brevard County Emergency Management and American Red Cross officials coordinated potential relief efforts Sunday night at the battered mobile home community clean-up crews used front-end loaders to collect bent-up metal debris and broken lumber with protruding nails that were strewn across the park Blue tarps appeared atop sections of various roofs to ward off light rainfall Don Sinclair and his girlfriend were watching angry-looking clouds swirling Sunday from his River Grove Drive mobile home when frightening lightning strikes chased her into the front porch "I walked out to the road and was watching and the spinning was going all the way around there it was — and a big chunk of metal was flying over the railroad tracks," Sinclair recalled and my girlfriend saw that carport fly off," he said "It was really loud — and the metal shearing from the aluminum was just .. the two of them together," he said of the suspected twister It was complete silence afterward," he said NWS forecasters issued a tornado warning for Micco "It was all about a cold front that was moving in from the west And the fact that we had a lot of energy in the atmosphere (that) led to a localized environment that was favorable for strong-to-severe storms developing in the area," Ulrich said "So that's kind of what triggered all of the weather that we saw between 4 and 7 p.m Rick Neale is the South Brevard Watchdog Reporter at FLORIDA TODAY (for more of his stories, click here.) Contact Neale at 321-242-3638 or rneale@floridatoday.com. Twitter: @RickNeale1 Support local journalism. Subscribe today. These last few months have certainly been a big statement for Lorna Shore Not only has the band skyrocketed to the forefront of deathcore but can arguably be seen as paving the way for extreme music to permeate culture further Between the release of their EP and the rollout of the new album Lorna Shore have shown there is a voracious appetite for heavy music that is also striking on an emotional level Lorna Shore is certainly at the top of their game right now setting the metal world ablaze as they flex the talents from shredding guitars blistering drums and Will Ramos mind-boggling vocal range Pain Remains is poised to be the standout album of 2022 the album has some surprising roots in video games and movie scores Guitarist Adam De Micco walked us through it track-by-track… That song came through in the middle of writing the record We knew what we wanted to first track to sound like in our heads We wanted it to have this kind of sound and nothing that we were writing at that point had this specific sound I started getting really into Doom and old 90’s first person shooters They redid Doom in 2016 and I played Doom Eternal a lot and I started going backwards and I would replay old Doom a lot I started thinking about it from that perspective I have to have a visual and a reason for writing a song the vision for that song was “If I was the Doom Slayer what soundtrack would I want playing in my helmet?” And that’s where I was coming from what song would I want to hear while killing demons with a shotgun?” The working title for it was “DM1-5” which is one of the names for the Doom Slayer It was all centered around this whole Doom Slayer soundtrack if you will up to that point a lot of the songs were put together not as a band I would finish writing the guitar riffs for a song then I would hand off the song to Will to write vocals or I would hand off the song to Austin to write drums It felt very mechanical and didn’t feel like we were a band But the fun thing about this song particularly was it was during the point of the writing process where we started having to work after hours We were up until 5:00 in the morning finishing the song It was at that point where you start to get cabin fever and start laughing and just dying at everything because you’re so delirious and that song was put together in that kind of headspace We left the studio with fragments of a song and came back the next day like “Here’s a fully fleshed out polished song.” For me it was just fun to sit in a room and put the song together as a band because we really hadn’t during the earlier parts of writing the record It was cool to have that morale and that enjoyment and I think that helped us gain momentum for finishing the rest of the record This was a really cool song for me to write because we had all these fragments of songs when we went into a writing session in June when we went into the writing session in September and I was like “We need to leave here with finished songs We need to have something finished.” And I was feeling really defeated because I wasn’t coming up with anything I liked he has different rooms and a studio B set-up and I was like “I’m going to be in here just leave me alone.” And I was feeling really defeated and low “I’m not going to be able to accomplish this I’m failing.” It was just a lot of negative self-talk And I remember walking around his neighborhood for a couple hours and being my own hype man because my morale was so low that I had to overcompensate to where it was borderline narcissistic It was sociopathic how I was having to hype myself up to the point where I could accomplish something And from that point I was like “I’m going to finish this song today and no one is going to tell me otherwise.” I was doing everything and it became a testament to myself This was a difficult song for many reasons It was another situation where we had a fragment of a song When we went back to the studio in November we had a couple other songs and we were comparing them and it wasn’t as aggressive and over the top as “Into the Earth” is and it wasn’t as melodic as some of the other songs Once we established the vision for the song that we wanted it to be this Skyrim or Lord of the Rings sound is how that song came about triumphant sounding song.” And that’s how the chorus came about Because we had this vision that we wanted this song to be this epic and triumphant sounding it made it easier to put the song together And it’s one of my favorite songs to play live My favorite thing about this song is the guitar solo That was the first guitar solo that I finished for the record and it really started me on doing the rest of the solos Because I started with that and it carried over through the rest of the record And it’s the perfect song to describe the band because it has everything that we’re doing Outside of the “Pain Trilogy” this is one of my favorite songs on the record How this song came about was that we had two writing sessions with our producer Josh: one in June/July and another one in September When we went in June/July we didn’t have anything written and I wanted to start the writing process with him For the first few days we were figuring out ideas and one day he said “Sometimes I just think of what I have been listening to whatever it may be.” And I remember I was listening I love that movie and I was listening to it because it would get me all hyped up But I was listening to the soundtrack and I had a keyboard in front of me and I was playing around with stuff and I wanted it to sound like it was coming from this really heavy And that’s how we came up with the melody for the song The intro melody to this song was one of the first things we had written for the record but we didn’t know where to put either one of those ideas It wasn’t until towards the end of the record that we finalized the song I was also listening to a lot of Def Leppard and I loved learning about how they wrote Hysteria Every song on that record was meant to be a single On their previous record they only had two singles but this one they had to have seven and that’s how Hysteria was such a big record because every song was hit after hit after hit And that was a big inspiration for this record So with “Cursed to Die,” I wanted to have a big So that’s why this song is the shortest one So that was the purpose of the song: “Let’s just try to write our version of a radio hit.” it makes me think it’s a stage in Street Fighter Hence the working title for the song was “Street Fighter” for the longest time And Jean-Claude Van Damme played Guile in Street Fighter This is another one that is a product of writing fragments I had pretty much the last chorus into the outro written but during one of the first writing sessions Josh was like “Why do we try to do other things and write in tempos that you don’t really do.” that’s just the tempo we chose and he was like “Why don’t we do other things.” Faster songs shorter songs and just try to mess with things and “Soulless Existence” is the slowest song on the record And it was very fun for me because I was very caught up in my feels and my emotions and I wasn’t really thinking about anything Because we had that fragment of the chorus into the outro Because the first four songs of the record are just really in your face and aggressive and we wanted it to feel like a cool down And that solo to the chorus and the outro is one of my favorite moments on the record because it’s so different for me doing stuff that is over the top and this forced me to be more reserved Apotheosis was one of the last songs that we finished Me and Austin sat down and we were like “We don’t know what to do.” We had checked off all of our boxes for this record We were finishing up the “Pain Trilogy,” we had all the singles that we wanted And we were like “Let’s just do the things we liked from other things that we’ve done.” And I know that sounds kind of weird or like we are copying ourselves but we also just like playing those things and hearing those things and those moments So we went back through our catalog and were like “What are moments on other songs that we really enjoy that we haven’t done on this record.” So it became this Frankenstein approach The only thing we had going in was the chorus And it was one of those choruses that sounded really sick it had to make the record and this was the perfect song to put it in This was something that we got home from our headline tour last year in October and went into the studio in November and me and Andrew were sitting together and we put together the first riff and then I one day started to write a bunch of other riffs And it’s always nice to have your band around you because they sometimes notice things that you don’t I wrote that intro riff and I didn’t really think anything of it and I showed Andrew and he was like “That is really sick The pre-chorus riff was something that we had from a previous writing session but we didn’t really know what to do with it The downside of having all these parts is that you don’t always know what to do with them The chorus is something I wrote between the tour and the studio At that time I was listening to a lot of film scores and I wanted this really regal sound But then Andrew said “If this was 2016 and you were writing Flesh Coffin what would you do?” And as soon as he said that it made putting the song together that much easier How this came about was that I always wanted to do a long two or three part song One of my favorite records of all time is Between the Buried and Me’s Colors I’m so into that record because I had never heard anything like that where it was just a continuation of one song And then The Faceless did Autotheist I,II & III and I always loved these long songs because you have more time to tell a story There’s a reason why Lord of the Rings is such a long movie because you need that much time to tell the story If you tried to condense Lord of the Rings into one but you’d miss so much of the grandiose big epic story because you have to cut things out This was our version of writing a really long film It all started centered around “Pain Remains II” The working title of that song was just “Pain Remains” give songs working titles that were kind of goofy or funny and I just sat and thought about how the song made me feel and it was just “Pain Remains.” I did not think that would become the name of the record and everything around it but it helped me keep the identity of the song because I was in a very emotional state and a very sad and painful state It all started with the chorus of the song and the chorus melody of the song is the melody that is in Part I Part II and the outro of Part III; it exists throughout this was something I had always wanted to do And we were sitting in the studio with Josh and he was like “What if we do a 3-part long song?” and I was like “Oh my god that is something I’ve always wanted to do.” And he was like “We already have Pain Remains Why don’t we just extend it to the beginning and the end and you already know how the middle of it is you gotta figure out how you got there and where it’s going.” But at that time “Pain Remains II” wasn’t finished As I was writing more parts for “Pain Remains II” And the worst part of writing the record for me was writing these songs This was at the lowest point of the record for me all the worst thoughts dealing with the pressure of the record and dealing with stuff in my own personal life but I was like “Leave me alone and let me go do this.” So “Pain Remains I” came about because I was writing for “Pain Remains II” That established a structure and we filled in the gaps And it made it easier to see where everything was going because you could kind of foreshadow into the future For “Pain Remains III” I wanted it to be like if you’re ending a film and you want it to be the biggest most grandiose thing you could possibly have but it didn’t really have this big grandiose ending What have we done?” It was an amazing moment as a band A lot of us were going through things personally it is very fitting to what some of us were going through I was talking to Will because I had an idea for lyrical content: I wanted it to be like loss grief and then just “fuck the world.” Because that’s kind of how I felt When you go through something and you have to deal with that loss and there is that grief and you can either pick yourself up and dust yourself off and go but sometimes you have that feeling of “fuck this place I don’t wanna be here anymore.” And that’s what really drove “Pain III” This idea of “I’m going to destroy this world with me in it.” you got broken up with and you’re just sitting in the shower crying; “Pain II” after you got broken up with and you just go lay in the snow to numb out; and “Pain III” is just setting the world ablaze even after this deep dive into this beautiful piece of music Of course people are going to gravitate to the Tyrannosaurus Rex But that’s not what I would describe myself as I’m definitely more scrappy and more aggressive…Velociraptor And I just love the idea of you and your homies The arrival of Pain Remains completes a extensive run up for the band in a year busy with international touring festival appearances and a skyrocketing trajectory the full length is paired with the band’s “The Pain Remains Tour” which sees Lorna Shore headlining North America with special guests Aborted The 26-date stretch nearly entirely sold out with just a handful of dates seeing limited tickets remaining Pain Remains from Lorna Shore is now available via Century Media Records – HERE Abu Dhabi Ports (ADP) has further expanded the range of its logistics services announcing today it had acquired local operator MICCO Logistics for an undisclosed sum It is the latest development in a clear trend of Middle Eastern port operators building up their presence in the logistics sector Danish 3PL DSV formally completed its €14.3bn ($16.3bn) acquisition of German peer DB Schenker today Following its clearance by competition regulators to complete its acquisition of DB Schenker The UK’s Competition and Markets Authority (CMA) has extended its deadline for a decision on .. email: [email protected] email: [email protected] email: [email protected] email: [email protected] email: [email protected] Get the best experience and stay connected to your community with our Spectrum News app. Learn More Fla — A major bridge replacement project is underway in south Brevard County and through traffic on Micco Road will be detoured for the next eight months Work presses on dismantling the 85-year-old bridge over the Sottile Canal and county leaders say it’s maxed out its life expectancy the bridge will be making way for a new $3,500,000 modern one but the detour isn’t sitting well with residents in the Lakes at St Sebastian Preserve like Nancy and Danny Fairchild Their entrance is yards away from the work site The closure means they and hundreds of other residents have to go all the way around “It takes an extra 40 miles round trip if you want to go to Winn Dixie or Publix This was very convenient for us,” Nancy Fairchild said The county has positioned an ambulance and a fire equipped brush truck on the west side of the construction to handle calls Micco Road is also a hurricane evacuation route for Barefoot Bay and surrounding areas This project isn’t expected to be complete before the season begins on June 1 County leaders encourage residents to plan ahead well before a storm comes who played guard on the Cal offensive line that helped propel quarterback Joe Roth and running back Chuck Muncie to stardom in the mid-1970s helping the Golden Bears to an 8-3 record and Pac-8 Conference co-title as a senior ranked 14th in the nation under coach Mike White Micco also played four seasons of rugby for Cal Micco's son Kelly paid tribute to his dad with these words on Facebook: was and always will be our hero and best friend He was the toughest SOB we knew but still a big teddy bear with an even bigger heart Kelly Micco said family was always most important to his dad along with a son and daughter and four grandchildren match or meet as either our coach or #1 supporter - he wouldn’t miss a thing His commitment and devotion as a husband and father inspired us and shaped us into the adults we are today We hope to be for our families just a fraction of what he was for us we will miss you every day but have comfort knowing you will be watching over us who came to the university a year after Micco also offered a tribute on his Facebook page a great Golden Bear,” Clark wrote on Facebook We offer the Micco family our deepest condolences." Former Cal linebacker/defensive end Dallas Hickman played football and rugby with Micco “The best thing that someone can say when it comes to a legacy is he was a good teammate That is so simply put but has so much content,” said Hickman who played six NFL seasons after his time at Cal Here is Clark's Facebook photo display honoring Micco: friend," former Cal football player Eric Swanson wrote on Facebook "One of the toughest guys I've played with and against -- coupled with a peaceful and gentle spirit Micco grew up in Contra Costa County and played at Concord’s Mt which inducted him into its athletic Hall of Fame in 2017 Diablo High School Athletic Hall of Fame in 2017 donates an annual $500 Micco Collegiate Scholarship Award given to a foster child or the son or daughter of an immigrant Others also paid tribute to Micco on social media: Follow Jeff Faraudo of Cal Sports Report on Twitter: @jefffaraudo Click the "follow" button in the top right corner to join the conversation on Cal Sports Report on SI Access and comment on featured stories and start your own conversations and post external links on our community page JEFF FARAUDOJeff Faraudo was a sports writer for Bay Area daily newspapers since he was 17 years old, and was the Oakland Tribune's Cal beat writer for 24 years. He covered eight Final Fours, four NBA Finals and four Summer Olympics.  The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Sports Illustrated or its affiliates All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER FLORIDA TODAY has made this article free to all readers in the interests of public safety. Please consider supporting local journalism with a digital subscription. Click here and subscribe today. Rich Armington felt nervous Tuesday: Some forecasts showed Tropical Storm Nicole crashing into southern Brevard County — and Barefoot Bay's 4,875 manufactured homes — as a menacing Category 1 hurricane The forecast track appears to have shifted southward overnight But meteorologists warn Nicole is a large storm packing tropical-storm-force winds that extend outward up to 460 miles — especially to the north of its center But I think we're going to be good enough that we're not going to get sustained (winds) of over 80," predicted Armington during a Wednesday morning interview in his office that's what it could take to take them out — the carports maybe they don't have the right screws in them Cocoa Beach mayor urges storm prep: Satellite Beach braces for Nicole's 80 mph winds 'Out of nowhere': Tropical Storm Nicole sends Brevard residents scrambling for sandbags Track storm, possible impacts in Brevard: Tropical Storm Nicole hits Bahamas with 70-mph winds. Micco is a census-designated place of roughly 9,600 residents — bolstered by a healthy snowbird population — that geographically extends along the Indian River Lagoon from Barefoot Bay southward to the St Barefoot Bay bills itself as Florida's largest deed-restricted manufactured-home community. In addition storm-vulnerable manufactured housing and recreational vehicle communities: Indian River Shores Should I evacuate? Tuesday afternoon, Brevard County Emergency Management issued a recommended evacuation for residents who live in mobile homes or manufactured housing The evacuation recommendation also applies to barrier-island residents; people who live in low-lying flood-prone areas; and residents with special medical needs Armington said he had fielded few calls about the approaching tropical storm from Barefoot Bay residents Some were from newer residents: "Do I have to evacuate Brevard officials opened a Nicole public storm shelter at 9 a.m Wednesday at the South Mainland Community Center in Micco No residents checked in during the opening 25 minutes but staffers expected a good number to start arriving in the afternoon Brevard County Emergency Management Director John Scott warned that Nicole could make landfall in southern Brevard County the tropical storm's track shifted southward overnight what I think we don't want to lose sight of is that this is still going to be a big deal for us We're still going to see a long duration — maybe a day-plus — of tropical-storm-force winds in the county," Scott said during a Wednesday morning video update Using a green ladder at the Micco Ridge Centre shopping plaza Barefoot Bay resident Ron Fashano labored amid intermittent gusty wind and rain to install metal shutters Wednesday morning at his wife Shirley's business offers upholstery work and classes in sewing Shirley Fashano lost her Port Charlotte home to Hurricane Charley in 2004 The couple installed clear shutters over the windows of their Barefoot Bay home in advance of Nicole's arrival "We're just hoping that it doesn't hurt anybody That maybe it pushes away a little bit and nobody's affected except for the wind and rain of course," Shirley Fashano said Rick Neale is the South Brevard Watchdog Reporter at FLORIDA TODAY (for more of his stories, click here.) Contact Neale at 321-242-3638 or rneale@floridatoday.com. Twitter: @RickNeale1 She has authored numerous books and articles including "African Americans and American Indians" in Encyclopedia of North American Indians (1996) "Tribal Re-Creations: Buffalo Child Long Lance and Black Seminole Narratives," in Vol 16 of Literary Studies East and West (Summer and two articles (2004-05) “To Be or Not To Be Indian: Construction of Identity for Native and African Americans in African Americans and Native Americans: Explorations in Narrative and Identity,” and “Blood and Money: The Case of Seminole Freedmen and Indians in Oklahoma” in Crossing Waters Crossing Paths: Black and Indian Journeys in the Americas Her film projects include the documentary Killing the 7th Generation: Reproductive Abuses against Indigenous Women (with Esther Lucero); and her current film project is Every Step A Prayer: Refinery Corridor Healing Walks about the Indigenous women-led campaign to end the production of oil and gas in communities of color such as Richmond Micco is a Professor Emerita of Ethnic Studies at Mills College Metrics details has become a focus for biotech companies that target it to ameliorate a variety of human conditions Eminently characterized by a permanent proliferation arrest cellular senescence occurs in response to endogenous and exogenous stresses oncogene activation and persistent DNA damage Cellular senescence can also be a controlled programme occurring in diverse biological processes broadly related to the activation of a senescence-associated secretory phenotype amplify the impact of cell-intrinsic proliferative arrest and contribute to impaired tissue regeneration chronic age-associated diseases and organismal ageing This Review discusses the mechanisms and modulators of cellular senescence establishment and induction of a senescence-associated secretory phenotype and provides an overview of cellular senescence as an emerging opportunity to intervene through senolytic and senomorphic therapies in ageing and ageing-associated diseases The serial cultivation of human diploid cell strains The limited in vitro lifetime of human diploid cell strains A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4 Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts Role of the INK4a locus in tumor suppression and cell mortality Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes Is cellular senescence an example of antagonistic pleiotropy Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders This study demonstrates that selective elimination of p16-expressing senescent cells is safe and capable of modulating age-related dysfunction in a premature aged mouse model An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA Senescent cells: an emerging target for diseases of ageing Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice Senescence and apoptosis: dueling or complementary cell fates Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53 Senescence-associated reprogramming promotes cancer stemness Mechanisms and functions of cellular senescence Impaired immune surveillance accelerates accumulation of senescent cells and aging The DNA-damage response in human biology and disease Stable cellular senescence is associated with persistent DDR activation A novel single-cell method provides direct evidence of persistent DNA damage in senescent cells and aged mammalian tissues A DNA damage checkpoint response in telomere-initiated senescence This study demonstrates that the activation of the DDR pathways by critically short telomeres is key in the enforcement of cellular senescence The DNA damage signaling pathway connects oncogenic stress to cellular senescence Reversal of human cellular senescence: roles of the p53 and p16 pathways Uncoupling between phenotypic senescence and cell cycle arrest in aging p21-deficient fibroblasts Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer Telomere shortening triggers senescence of human cells through a pathway involving ATM is critical for cell viability and chromosome stability Extension of life-span by introduction of telomerase into normal human cells Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence A RAP1/TRF2 complex inhibits nonhomologous end-joining at human telomeric DNA ends DNA damage response inhibition at dysfunctional telomeres by modulation of telomeric DNA damage response RNAs An oncogene-induced DNA damage model for cancer development A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy A functional genetic screen defines the AKT-induced senescence signaling network Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions Oncogene-induced reactive oxygen species fuel hyperproliferation and DNA damage response activation Mitochondrial dysfunction and cell senescence: deciphering a complex relationship Mitochondrial dysfunction induces senescence with a distinct secretory phenotype Mitochondria are required for pro-ageing features of the senescent phenotype Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer Molecular dissection of formation of senescence-associated heterochromatin foci Redistribution of the lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence A novel indication for panobinostat as a senolytic drug in NSCLC and HNSCC Histone deacetylase inhibitors induce a senescence-like state in human cells by a p16-dependent mechanism that is independent of a mitotic clock Higher-order unfolding of satellite heterochromatin is a consistent and early event in cell senescence Lysosome-mediated processing of chromatin in senescence Autophagy mediates degradation of nuclear lamina Cytoplasmic chromatin triggers inflammation in senescence and cancer This study demonstrates that cytoplasmic chromatin in senescent and cancer cells activates the innate immunity through the cGAS–STING pathway Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions L1 drives IFN in senescent cells and promotes age-associated inflammation Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence Senescent cells harbour features of the cancer epigenome DNA methylation patterns separate senescence from transformation potential and indicate cancer risk NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements Lamin B1 depletion in senescent cells triggers large-scale changes in gene expression and the chromatin landscape Lamin B1 loss is a senescence-associated biomarker The role of nuclear lamin B1 in cell proliferation and senescence BRD4 connects enhancer remodeling to senescence immune surveillance Histone acetyltransferase p300 induces de novo super-enhancers to drive cellular senescence A complex secretory program orchestrated by the inflammasome controls paracrine senescence Oncogene-induced senescence relayed by an interleukin-dependent inflammatory network Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor The senescence-associated secretory phenotype: the dark side of tumor suppression A human-like senescence-associated secretory phenotype is conserved in mouse cells dependent on physiological oxygen PAI-1-regulated extracellular proteolysis governs senescence and survival in Klotho mice Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses A proteomic atlas of senescence-associated secretomes for aging biomarker development Unmasking senescence: context-dependent effects of SASP in cancer Plasma proteomic signature of age in healthy humans Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3 Jakhar, R. & Crasta, K. Exosomes as emerging pro-tumorigenic mediators of the senescence-associated secretory phenotype. Int. J. Mol. Sci. https://doi.org/10.3390/ijms20102547 (2019) Tumor suppressor and aging biomarker p16(INK4a) induces cellular senescence without the associated inflammatory secretory phenotype Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion This study demonstrates that persistent DDR activation controls SASP induction in senescent cells MacroH2A1 and ATM play opposing roles in paracrine senescence and the senescence-associated secretory phenotype p38MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype DNA damage responses and p53 in the aging process Shmulevich, R. & Krizhanovsky, V. Cell senescence, DNA damage, and metabolism. Antioxid. Redox Signal. https://doi.org/10.1089/ars.2020.8043 (2020) Chemokine signaling via the CXCR2 receptor reinforces senescence NOTCH1 mediates a switch between two distinct secretomes during senescence The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4 Genetic interrogation of replicative senescence uncovers a dual role for USP28 in coordinating the p53 and GATA4 branches of the senescence program Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network Enhancing chemotherapy efficacy in Pten-deficient prostate tumors by activating the senescence-associated antitumor immunity JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age Unmasking transcriptional heterogeneity in senescent cells Notch is a direct negative regulator of the DNA-damage response NOTCH1 inhibits activation of ATM by impairing the formation of an ATM-FOXO3a-KAT5/Tip60 complex BET proteins as targets for anticancer treatment A BET family protein degrader provokes senolysis by targeting NHEJ and autophagy in senescent cells Regulation of cellular senescence by polycomb chromatin modifiers through distinct DNA damage- and histone methylation-dependent pathways MLL1 is essential for the senescence-associated secretory phenotype HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci p53-dependent release of alarmin HMGB1 is a central mediator of senescent phenotypes Nuclear pore density controls heterochromatin reorganization during senescence Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence Molecular mechanisms and cellular functions of cGAS-STING signalling Downregulation of cytoplasmic DNases is implicated in cytoplasmic DNA accumulation and SASP in senescent cells Targeting STING with covalent small-molecule inhibitors The innate immune sensor Toll-like receptor 2 controls the senescence-associated secretory phenotype LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation Stem cells and aging in the hematopoietic system Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age McNeely, T., Leone, M., Yanai, H. & Beerman, I. DNA damage in aging, the stem cell perspective. Hum. Genet. https://doi.org/10.1007/s00439-019-02047-z (2019) Genotoxic stress abrogates renewal of melanocyte stem cells by triggering their differentiation This study demonstrates that DNA damage can induce stem cell differentiation A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage Precise gene editing preserves hematopoietic stem cell function following transient p53-mediated DNA damage response Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells DNA damage in mammalian neural stem cells leads to astrocytic differentiation mediated by BMP2 signaling through JAK-STAT Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells Senescence is a developmental mechanism that contributes to embryonic growth and patterning Programmed cell senescence during mammalian embryonic development Cellular senescence in postmitotic cells: beyond growth arrest Postmitotic neurons develop a p21-dependent senescence-like phenotype driven by a DNA damage response Obesity-induced cellular senescence drives anxiety and impairs neurogenesis Tau protein aggregation is associated with cellular senescence in the brain Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy A crucial role for adipose tissue p53 in the regulation of insulin resistance Targeting cellular senescence prevents age-related bone loss in mice Anderson, R. et al. Length-independent telomere damage drives post-mitotic cardiomyocyte senescence. EMBO J. https://doi.org/10.15252/embj.2018100492 (2019) Physiological and pathological consequences of cellular senescence Cell fusion induced by ERVWE1 or measles virus causes cellular senescence Molecular pathways of senescence regulate placental structure and function Conserved and novel functions of programmed cellular senescence during vertebrate development Senescence of activated stellate cells limits liver fibrosis This study demonstrates that immune cell targeting of senescent cells limits dysfunction in the liver Matricellular protein CCN1 promotes regression of liver fibrosis through induction of cellular senescence in hepatic myofibroblasts The matricellular protein CCN1 induces fibroblast senescence and restricts fibrosis in cutaneous wound healing Senescence determines the fate of activated rat pancreatic stellate cells Cell senescence contributes to tissue regeneration in zebrafish Yun, M. H., Davaapil, H. & Brockes, J. P. Recurrent turnover of senescent cells during regeneration of a complex structure. eLife https://doi.org/10.7554/eLife.05505 (2015) Immunosurveillance of senescent cells: the bright side of the senescence program Inflammatory networks during cellular senescence: causes and consequences Non-cell-autonomous tumor suppression by p53 ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas Senescence surveillance of pre-malignant hepatocytes limits liver cancer development NKG2D ligands mediate immunosurveillance of senescent cells Senescent cells communicate via intercellular protein transfer NK cell-mediated cytotoxicity contributes to tumor control by a cytostatic drug combination Tumour-infiltrating Gr-1+ myeloid cells antagonize senescence in cancer Distinct functions of senescence-associated immune responses in liver tumor surveillance and tumor progression Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma Uncoupling the senescence-associated secretory phenotype from cell cycle exit via interleukin-1 inactivation unveils its protumorigenic role Cellular senescence promotes adverse effects of chemotherapy and cancer relapse An evolutionary perspective on immunosenescence Review: a meta-analysis of GWAS and age-associated diseases Genetic polymorphisms and human aging: association studies deliver A common variant of the p16(INK4a) genetic region is associated with physical function in older people Genetic evidence for common pathways in human age-related diseases Association between shortened leukocyte telomere length and cardiometabolic outcomes: systematic review and meta-analysis Tracking and fixed ranking of leukocyte telomere length across the adult life course Aging and the burden of multimorbidity: associations with inflammatory and anabolic hormonal biomarkers Senolytics improve physical function and increase lifespan in old age This study demonstrates that transplanting senescent cells in young mice causes persistent physical dysfunction that can be alleviated by senolytic drugs Senescent intimal foam cells are deleterious at all stages of atherosclerosis Expression of Chr9p21 genes CDKN2B (p15(INK4b)) p14(ARF)) and MTAP in human atherosclerotic plaque Oncogene-induced senescence as a new mechanism of disease: the paradigm of erdheim-chester disease BRAFV600E-mutation is invariably present and associated to oncogene-induced senescence in Erdheim-Chester disease Muscle stem cell aging: regulation and rejuvenation An early-senescence state in aged mesenchymal stromal cells contributes to hematopoietic stem and progenitor cell clonogenic impairment through the activation of a pro-inflammatory program Stem cells: The promises and perils of p53 Senescence impairs successful reprogramming to pluripotent stem cells The Ink4/Arf locus is a barrier for iPS cell reprogramming Mosteiro, L. et al. Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science https://doi.org/10.1126/science.aaf4445 (2016) Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7 Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2 Suppression of type I interferon signaling overcomes oncogene-induced senescence and mediates melanoma development and progression Bird, T. G. et al. TGFbeta inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence. Sci. Transl Med. https://doi.org/10.1126/scitranslmed.aan1230 (2018) The senescence-associated secretory phenotype induces cellular plasticity and tissue regeneration Injury-induced senescence enables in vivo reprogramming in skeletal muscle BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice The yin and yang of the Cdkn2a locus in senescence and aging Opposing roles for p16Ink4a and p19Arf in senescence and ageing caused by BubR1 insufficiency Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan Mitochondrial DNA damage induces apoptosis in senescent cells Cellular senescence is induced by the environmental neurotoxin paraquat and contributes to neuropathology linked to Parkinson’s disease Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model Cellular senescence mediates fibrotic pulmonary disease p53 in bronchial club cells facilitates chronic lung inflammation by promoting senescence Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment New agents that target senescent cells: the flavone Cardiac glycosides are broad-spectrum senolytics Identification and characterization of cardiac glycosides as senolytic compounds The curcumin analog EF24 is a novel senolytic agent Targeted apoptosis of senescent cells restores tissue homeostasis in response to chemotoxicity and aging Inflammation and the depot-specific secretome of human preadipocytes Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice Fisetin is a senotherapeutic that extends health and lifespan The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease Senolytics in idiopathic pulmonary fibrosis: results from a first-in-human Hsp90 inhibitors as senolytic drugs to extend healthy aging Identification of HSP90 inhibitors as a novel class of senolytics Discovery of piperlongumine as a potential novel lead for the development of senolytic agents Senolytic activity of piperlongumine analogues: synthesis and biological evaluation Azithromycin and roxithromycin define a new family of “senolytic” drugs that target senescent human fibroblasts Munoz-Espin, D. et al. A versatile drug delivery system targeting senescent cells. EMBO Mol. Med. https://doi.org/10.15252/emmm.201809355 (2018) Galactose-modified duocarmycin prodrugs as senolytics Galacto-conjugation of navitoclax as an efficient strategy to increase senolytic specificity and reduce platelet toxicity IL-21 enhances natural killer cell response to cetuximab-coated pancreatic tumor cells The interactions of multiple cytokines control NK cell maturation Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes IL-15 signaling in NK cell cancer immunotherapy This study demonstrates the feasibility of targeting senescent cells in a variety of conditions by chimeric antigen receptor T cell-mediated therapy Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody Identification of senescent cell surface targetable protein DPP4 Characterization of novel markers of senescence and their prognostic potential in cancer mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1 Progressive slowdown/prevention of cellular senescence by CD9-targeted delivery of rapamycin using lactose-wrapped calcium carbonate nanoparticles Rapamycin fed late in life extends lifespan in genetically heterogeneous mice Metformin inhibits the senescence-associated secretory phenotype by interfering with IKK/NF-kappaB activation Diabetes medications as monotherapy or metformin-based combination therapy for type 2 diabetes: a systematic review and meta-analysis Metformin-mediated increase in DICER1 regulates microRNA expression and cellular senescence Effects of flavonoids on senescence-associated secretory phenotype formation from bleomycin-induced senescence in BJ fibroblasts NAD+ metabolism governs the proinflammatory senescence-associated secretome Simvastatin suppresses breast cancer cell proliferation induced by senescent cells Glucocorticoids suppress selected components of the senescence-associated secretory phenotype Treatment of rheumatoid arthritis with anakinra a recombinant human interleukin-1 receptor antagonist in combination with methotrexate: results of a twenty-four-week a fully human IgG1 anti-IL-1β mAb) induces sustained remission in pediatric patients with cryopyrin-associated periodic syndrome (CAPS) Efficacy and safety of rilonacept (interleukin-1 trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial The effectiveness of infliximab and etanercept for the treatment of rheumatoid arthritis: a systematic review and economic evaluation IL-6 receptor inhibition with tocilizumab improves treatment outcomes in patients with rheumatoid arthritis refractory to anti-tumour necrosis factor biologicals: results from a 24-week multicentre randomised placebo-controlled trial Siltuximab for multicentric Castleman’s disease: a randomised and nordihydroguaiaretic acid extend mouse lifespan preferentially in males Damage-induced lncRNAs control the DNA damage response through interaction with DDRNAs at individual double-strand breaks Inhibition of DNA damage response at telomeres improves the detrimental phenotypes of Hutchinson-Gilford progeria syndrome Aging of mice is associated with p16(Ink4a)- and beta-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells Cells exhibiting strong p16 (INK4a) promoter activation in vivo display features of senescence Grosse, L. et al. Defined p16(High) senescent cell types are indispensable for mouse healthspan. Cell Metab. https://doi.org/10.1016/j.cmet.2020.05.002 (2020) Extending healthy life span–from yeast to humans Ink4a/Arf expression is a biomarker of aging The effects of graded caloric restriction: XII Comparison of mouse to human impact on cellular senescence in the colon short-term dietary restriction reduces cell senescence in mice Mitogen stimulation cooperates with telomere shortening to activate DNA damage responses and senescence signaling Telomere-driven diseases and telomere-targeting therapies A natural product telomerase activator lengthens telomeres in humans: a randomized Therapeutic effect of androgen therapy in a mouse model of aplastic anemia produced by short telomeres Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer IPF lung fibroblasts have a senescent phenotype Povedano, J. M. et al. Therapeutic effects of telomerase in mice with pulmonary fibrosis induced by damage to the lungs and short telomeres. eLife https://doi.org/10.7554/eLife.31299 (2018) AAV9-mediated telomerase activation does not accelerate tumorigenesis in the context of oncogenic K-Ras-induced lung cancer Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity Human umbilical cord plasma proteins revitalize hippocampal function in aged mice Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches Yousefzadeh, M. J. et al. Heterochronic parabiosis regulates the extent of cellular senescence in multiple tissues. Geroscience https://doi.org/10.1007/s11357-020-00185-1 (2020) US National Library of Medicine. ClinicalTrials.gov https://clinicaltrials.gov/ct2/show/NCT04057872 (2019) US National Library of Medicine. ClinicalTrials.gov https://www.clinicaltrials.gov/ct2/show/NCT03702920 (2018) Senescent cell turnover slows with age providing an explanation for the Gompertz law Chemical screening identifies ATM as a target for alleviating senescence A biomarker that identifies senescent human cells in culture and in aging skin in vivo p16(Ink4a) and senescence-associated beta-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli universal biomarker assay to detect senescent cells in biological specimens excessive cell growth causes cytoplasm dilution and contributes to senescence Quantitative identification of senescent cells in aging and disease The meaning of p16(ink4a) expression in tumors: functional significance clinical associations and future developments Targeting senescent cells in translational medicine Real-time imaging of senescence in tumors with DNA damage Spatial coupling of mTOR and autophagy augments secretory phenotypes Autophagy mediates the mitotic senescence transition Synthetic lethal metabolic targeting of cellular senescence in cancer therapy Autophagy maintains stemness by preventing senescence Autophagy impairment with lysosomal and mitochondrial dysfunction is an important characteristic of oxidative stress-induced senescence Download references a Career Development Award from the Human Frontier Science Program an Advanced Research Grant from the European Haematology Association “Pilot and Seed Grant 2015” from San Raffaele Hospital a Hollis Brownstein Research Grant from the Leukemia Research Foundation the Interstellar Initiative on Healthy Longevity of the New York Academy of Sciences and the Japan Agency for Medical Research and Development is supported by grants from the European Research Council under the European Union’s Seventh Framework Proframme (309688) and under Horizon 2020 (856487) from the Israel Science Foundation (634-15; 2633-17) and from the Sagol Institute for Longevity Research is supported by the Ellison Medical Foundation the US National Institutes of Health (R01AG053229 and R01AG068076) the Mayo Clinic Children’s Research Center the Alzheimer’s Disease Research Center at Mayo Clinic and the Cure Alzheimer’s Fund the AMANDA project Accordo Quadro Regione Lombardia-CNR a European Research Council advanced grant (322726) a European Research Council proof-of-concept grant (875139) the AIRC Special Program 5 per mille metastases (Project-21091) and the European Joint Programme on Rare Diseases (EJP RD).The authors apologize for not being able to cite all the important contributions of their colleagues owing to space limitations Department of Biochemistry and Molecular Biology IFOM — The FIRC Institute of Molecular Oncology The authors contributed equally to the writing and revision of the article is a co-inventor on patent applications licensed to or filed by Unity Biotechnology including small molecules that selectively eliminate senescent cells Research in the Baker laboratory has been reviewed by the Mayo Clinic Conflict of Interest Review Board and is being conducted in compliance with Mayo Clinic conflict of interest policies is a co-inventor on patent applications in the field of senolytics is among the inventors on patent applications for the use of antisense oligonucleotides to target DNA damage-induced transcripts Nature Reviews Molecular Cell Biology thanks Daniel Muñoz-Espín and the other reviewer(s) for their contribution to the peer review of this work Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations Transgenic mouse model with drug-inducible caspase 8 under the control of a minimal p16 promoter element active in senescent cells to allow selective elimination of p16-expressing senescent cells Transgenic mouse model expressing a trimodal reporter of red fluorescent protein luciferase and herpes simplex virus thymidine kinase under the control of the p16 promoter to allow tracking and elimination of p16-expressing senescent cells Nicotinamide dinucleotide (NAD+)-dependent deacylases that regulate diverse cellular processes Mitochondrial damage triggers senescence with a distinct secretory phenotype that lacks IL-1-dependent inflammation Extracellular vesicles produced by the endosomal compartment involved in intercellular communication Non-histone molecules that bind DNA and affect chromatin compaction An age-related proportional increase in myeloid cells at the expense of other lineages as observed in the bone marrow and blood A protein found in neurons that is important for maintaining microtubule structure in axons Mutants and hyperphosphorylated forms are found in a variety of neurodegenerative diseases Pathological accumulation of extracellular matrix in diseases tissue that limits normal tissue function and leads to long-term tissue scaring Mutations in the gene encoding this receptor predispose to the development of atherosclerosis Clouding of the lens in the eye leading to inability to have clear vision Surgical intervention to replace diseased lenses is a common medical procedure in aged humans observed both in laboratory mice and in humans Abnormal distribution of adipose tissue in the body can refer to both excessive or insufficient deposition A molecular chaperone that promotes proper protein folding and degradation which also contributes to heat stress resilience Compounds that are metabolized into an active drug to modify drug bioavailability and activity A pore forming protein expressed in cytotoxic T cells and natural killer cells which binds to the target cell’s membrane and forms pores on the target cell in order to allow cytotoxicity T cells that have been genetically engineered to express T cell receptor developed to bind a defined target in order to eliminate the cells that have the target on their membrane A protein expressed on the cell surface that inhibits the ability of the immune system to target the cells that express the protein Inhibition of interaction of PD1 with its ligand is a potent immunotherapy approach Download citation DOI: https://doi.org/10.1038/s41580-020-00314-w Combined PET-MRI is a relatively new approach so it’s generally only used in clinical research.” Results of this technique are still affected by a high percentage of false positives and should therefore be confirmed by further testing The new study led by Professor Oreste Gentilini includes 205 patients who were being treated at San Raffaele Hospital between July 2020 and October 2023 Before being offered breast-conserving surgery to remove the tumour each patient was given a PET-MRI scan to look for signs of cancer spread in the affected breast the surrounding area and the rest of the body their planned treatment was altered based on the results of the PET-MRI scan 18 had chemotherapy as a first-line treatment and the remaining 39 had different surgical approaches removal of extra lymph nodes and surgery on both breasts additional tumour tissue removed turned out to be benign.  Dr Di Micco said: “Our research suggests that for patients with early breast cancer the addition of a PET-MRI scan to standard care could help us make more informed decisions about the best treatment pathway results of this technique are still affected by a high percentage of false positives and should therefore be confirmed by further testing.” Professor Gentilini said: “These are early results from an ongoing study but they suggest that a PET-MRI scan could refine treatment for some breast cancer patients They also suggest that this is an area where more research could be beneficial.”  Dr Di Micco and her colleagues are also beginning a new study using a slightly different PET-MRI approach that should help detect breast cancer cells that grow in response to the female hormone oestrogen This could be particularly helpful for patients with lobular breast cancer which can be harder to see on mammograms or ultrasounds scans.  Professor Michail Ignatiadis from the Institut Jules Bordet in Brussels is Chair of the 14th European Breast Cancer Conference and was not involved in the research this will be one of the largest studies of its kind looking at PET-MRI before surgery for patients with early breast cancer We look forward to more results from this study but these findings suggest that PET-MRI could help spot early signs that breast cancer has begun to spread Spotting these signs might give people the best chance of long-term survival We now need studies to prospectively test this hypothesis.”  Source: European Organisation for Research and Treatment of Cancer Despite their improving diagnostic accuracy medical AI systems are often met with skepticism by radiologists seem more inclined to embrace this technology A new PET tracer has the potential to play a critical role in the diagnosis and monitoring of aggressive triple-negative breast cancer (TNBC) A new AI-enhanced technique makes breast cancer tissue “glow” on MRI scans This not only improves breast cancer detection but also can help treat it more effectively This website uses cookies to give our readers the best website experience. Please refer to our privacy policy to find out how we use cookies and how you can edit your preferences but nine years after a devastating accident Written by Emily BeersLast updated on August 2nd It was 2011: Joe Micco was 27 and had his whole life ahead of him A former college and professional football player Micco had just accepted a coaching position in the Arena Football League and was set to become the youngest coach in the league he was in a devastating motorcycle crash in Georgia that left him in a coma for three months The brain injury he suffered still limits the functionality of the right side of his body I don’t even remember ever riding a motorcycle,” said Micco doctors didn’t think he would survive the night they were prepared to diagnose him “to be a vegetable,” he said Micco is committed to using fitness and nutrition to help him regain function He trains at home and also works at a gym with coach Kelly Rosado but he can do things like bodyweight lunges and step-ups and hanging L-sits and planks He still doesn’t have function in his right arm but he can do push-ups and burpees with one arm “Sometimes I fall into the mindset of how my body used to be. I don’t remember the accident so much as I remember I was a professional athlete,” said Micco, who used to be able to bench press 500 pounds Having this mindset has helped him exceed expectations as to what is possible “but the drawback is that I often have unrealistic expectations of myself,” he admitted He credits much of his success to Rosado’s coaching “Verbally instructing requires more knowledge of technique Kelly’s verbal skills are unparalleled,” he added Rosado replied humbly: “All I’ve done with Joe is observed where his limitations are and come up with a plan to better his movement Joe and I consistently reevaluate his goals We figure out what he’s not capable of doing and we come up with a plan to make him better,” she said Some of the things Rosado has helped him with include sitting and standing without support and moving his arms over his head,” she explained She added: “He has made so much progress this year.” even better than being able to do lunges and ring rows is the fact that “everyday tasks no longer present a challenge,” Micco said Better than being able to do lunges and ring rows is the fact that “everyday tasks no longer present a challenge,” Micco said On top of being committed to his own health and fitness, Micco is also passionate about helping other adaptive athletes become educated on how they can regain functionality an organization that seeks to enrich the community of adaptive athletes by sharing information He’s still in the process of building Adaptive Alliance but so far it has proven to be a valuable place for personal networking He hopes it will continue to grow so it can eventually reach a much wider audience Micco’s message: Don’t just accept your prognosis “You’re always going to be told the worst case scenario by medical professionals He added: “I’d love to see if whoever decided that could even do Fran She has also been coaching fitness at MadLab School of Fitness in Vancouver A former college basketball player and rower Emily became heavily involved in CrossFit after finishing her Masters degree in journalism at the University of Western Ontario She competed at the 2014 CrossFit Games and also worked with CrossFit Inc.’s media team for 8 years You can also find her work at Precision Nutrition and a host of other fitness and nutrition companies and media outlets The views expressed on this site may come from individual contributors and do not necessarily reflect the view of BarBend or any other organization BarBend is the Official Media Partner of USA Weightlifting Copyright © 2025 · BarBend Inc · Sitemap He said he believes there's a niche for the aircraft It's the only one on the market that fits the bill." Beckett and his partner moved the operation to Bartlesville last year after years of wrangling with investors and the Seminole tribe which tried to auction off the assets of the Fort Pierce operation in 2001 Three hurricanes finished off what was left of the production facility and Beckett and Billie were able to bring what was left to Oklahoma Beckett said they're now gathering and making parts for the first five airplanes and if interest in the aircraft continues to build he hopes to make two aircraft a month in coming years MICCO — Rose Lohr found herself taking shelter again at the South Mainland Community Center in Micco 12 years after the 2004 hurricane season devastated her home in Snug Harbor "I told myself I was never going to go through this again who was able to have her home repaired after Hurricanes Frances and Jeanne Snug Harbor is one of about half a dozen manufactured home communities in the Micco area All were ordered to evacuate for Hurricane Matthew Lohr said she arrived Wednesday at the shelter at the dead end of Allen Avenue She said staff from the American Red Cross have been welcoming to the handful of people who chose to leave their homes well before the tropical-force winds struck southern Brevard County The Red Cross bought pizza for the evacuees Wednesday Only a dozen or two people were at the shelter Thursday morning but buses were on hand in Barefoot Bay to transport residents there Brevard County Emergency Management could not be reached Thursday night about the number of evacuees at the Micco shelter but I'm sure more people will be coming," Lohr said Thursday morning more than 800 homes in Barefoot Bay were destroyed by Hurricanes Frances and Jeanne with more losses in other Micco communities Lohr said her home was nearly one of those; she stayed at a relative's home while repairs were made Other homes in Micco will likely withstand Matthew's force who moved into a home on the corner of Tenth Street and Central Avenue in 2005 said the home was in good condition after the previous year's storms He was boarding up his windows Thursday morning Brightline's first passenger train in Brevard County will now likely cross the St Sebastian River and enter southernmost Micco sometime after 10 a.m The privately held higher-speed rail company will start sending "qualifying trains" on daily roundtrips along the Florida East Coast Railway corridor between West Palm Beach and Frontenac Brightline locomotive engineers and train conductors will learn the territory and practice through year's end traveling at freight-train speeds of 60 mph and slower • Tuesday's train is scheduled to depart West Palm Beach at 7 a.m. then arrive in Micco sometime after 10 a.m The train will head north of the Holly Street crossing in the Little Hollywood neighborhood before stopping and heading back to South Florida • Wednesday's train will depart West Palm Beach at 7 a.m. then arrive in Cocoa sometime after 11 a.m Trains will stop in Frontenac, a small unincorporated community between Sharpes and Port St These daily qualifying trains will continue through year's end More: Brightline trains to begin rolling from Cocoa to West Palm Beach — without passengers More: Brightline planning 320-mile Florida passenger rail route from Miami to Tampa by 2028 "Operating a train requires engineers and conductors to be intimately familiar with the rail corridor curves and speed restrictions," a Brightline press release said Brightline train crews will work with a manager already qualified on the territory who will provide oversight and instruction," the press release said Construction crews have finished building more than 70% of Brightline’s $2.7 billion higher-speed rail extension from West Palm Beach to Orlando International Airport Brightline launched passenger service in 2018 along a 67-mile route linking Miami Company officials want to debut passenger service to Orlando early next year Rick Neale is the South Brevard Watchdog Reporter at FLORIDA TODAY (for more of his stories, click here.) Contact Neale at 321-242-3638 or rneale@floridatoday.com. Twitter: @RickNeale1 Thousands of new homes could be coming to South Brevard County with construction beginning early next year after an Oviedo company made a major land buy last month Property records show SunTerra Communities scooped up over a thousand acres near Babcock Street and Micco Road in late February for just over $28 million Developers are looking at building approximately 2,700 residential units along with some commercial construction on the property, dubbed SunTerra Lakes, with groundbreaking beginning by the second quarter of 2025, according to the SunTerra website. Since the completion of the St. Johns Heritage Parkway connecting Melbourne and Palm Bay on the west side of Interstate 95, homes have sprouted up like weeds as developers have plans to add thousands of housing units to the previously undeveloped land More: Palm Bay officials celebrate opening of I-95 St. Johns Heritage Parkway interchange said South Brevard County is poised for massive growth and that the job market in the county has made it attractive for new housing Although SunTerra Lakes is still in the beginning stages Johns Heritage Parkway interchange with Interstate 95 for opening up the area for housing "There's been a lot of growth since the St. Johns Heritage Parkway interchange opened. There's also a Publix under development at that intersection nearby," "It's clear this is the path for development There's quite a lot of residential rooftops going up right now." We certainly feel there's a lot of potential and growth that will occur naturally in Brevard County," Edwards added Later this year, construction is expected to begin on nearby Ashton Park, a large-scale Orlando-based Dix Developments is expected to break down on the 1,512-acre development by the end of 2024 It will include a 39-acre town center that will provide residents with a variety of options for groceries and other retail shopping along with 4,107 single-family residential units 1,031 town homes and more than 5.4 million square feet of commercial/flex space Other large-scale projects near South Brevard and Palm Bay include Everlands a subdivision with single- and multi-family residences that will bring 1,238 homes on 450 acres north of Palm Bay Regional Park and east of St Tyler Vazquez is the Brevard Watchdog Reporter at FLORIDA TODAY. Contact Vazquez at 321-480-0854 or tvazquez@floridatoday.com. Volume 9 - 2018 | https://doi.org/10.3389/fpls.2018.01053 producing tree rings composed of large-lumen and thin-walled cells (earlywood) alternating with narrow-lumen and thick-walled cells (latewood) the physiology behind wood formation processes and the associated kinetics has rarely been considered to explain this pattern We developed a process-based mechanistic model that simulates the development of conifer tracheids explicitly considering the processes of cell enlargement and the deposition and lignification of cell walls The model assumes that (1) wall deposition gradually slows down cell enlargement and (2) the deposition of cellulose and lignin is regulated by the availability of soluble sugars The model reliably reproduces the anatomical traits and kinetics of the tracheids of four conifer species low sugar availability in the cambium results in slow wall deposition that allows for a longer enlargement time; thus high sugar availability produces narrower cells having thick cell walls (i.e. This modeling framework provides a mechanistic link between plant ecophysiology and wood phenology and significantly contributes to understanding the role of sugar availability during xylogenesis the physiological factors influencing the rate and duration of the tracheid formation processes that determine their specific morphology primary growth in the tree canopy could influence the sugar availability for xylogenesis and contribute to the anatomical changes from earlywood to latewood The general anatomical pattern observed in conifers where each tree ring is composed of large and thin-walled earlywood tracheids followed by narrow and thick-walled latewood tracheids could thus be determined by the C allocation pattern during the growing season The authors demonstrated how a single morphogenetic gradient (e.g. IAA) could explain xylem radial growth and tissue zonation but failed to explain final cell sizes observed in tree rings They speculated that a second gradient might be at work to explain both emergent properties Although providing reliable predictions, the above-mentioned models assumed fixed ad hoc rules for the succession of cell-differentiation phases. Furthermore, none explicitly considered possible feedback between the enlargement processes and deposition of new wall material (i.e., downregulation Huang et al., 2012) which could have a significant impact on the emergent properties of the system on the variations in cell traits observed across tree rings we present a process-based model to explain the observed intra-annual variations of the traits of xylem cells by explicitly simulating cell enlargement as well as cell-wall deposition and lignification With this model—assuming that sugar availability for cambial activity increases when primary growth ends—we aim specifically to understand how such seasonal changes could impact the general anatomical pattern of tracheids across the tree ring and the rate and duration of cell enlargement and cell-wall formation Here we present a novel process-based model that reproduces the morphogenetic development of differentiating xylem tracheids The initial state of the simulated cell is that of a derivative produced by the cambium toward the xylem side and enclosed by a layer of primary cell wall The cell is described in transverse section by three state variables that represent the entire cell area (CA μm2) and the portion of lignified wall (LWA while cellulose microfibrils are synthesized through the hexameric complexes directly in the plasma membrane toward the developing cell wall monolignols) are synthesized in the protoplast and are transported to the wall surface by vesicles whose trafficking is quicker and more efficient in cells having a larger contact surface between the wall and lumen Following the principle of parsimony, the effect of environmental factors (i.e., temperature and water availability) on the considered processes was not explicitly included in the model. In particular, water availability was assumed to not be a limiting factor, while temperature has a direct effect only on the wall deposition of the last latewood cells (Cuny and Rathgeber, 2016) the dynamics of cell enlargement are described by the differential equation: where vc is the specific cell enlargement rate CAmax is maximum surface area that the cell can attain and WT* is the threshold thickness at which the cell enlargement process stops The most important feature of Equation (1) is its dependency on wall thickness [1-min(1,WT/WT*)] which is derived directly from the fourth assumption The remainder of the equation represents a simple logistic growth in which the term CAmax is assumed to be the theoretical upper limit of cell expansion in the absence of wall deposition based on the assumption of a rectangular shape of the cell where CTD and CRD are the cell tangential and cell radial dimensions As no tangential growth was assumed in the model while CRD is calculated at each time step (CRD = CA/CTD) The dynamics of cell-wall deposition are described by the differential equation: where vw is the specific rate of wall deposition Si is sugar availability within the ith cell of the ring WAmax is the maximum amount of wall that a cell can accumulate and mw and sw are calibration parameters Death is a Boolean variable that sets the death of the cell when the wall is completely lignified according to: The dynamics of cell-wall lignification are described through the differential equation: where vl is the specific wall lignification rate, while ml and sl are both calibration parameters (Table 1) Explanation and simulation values of the symbols used in the model The measured values of the lumen area (LA) lumen radial diameter (LRD) and wall thickness (WT) were used to derive the cell tangential diameter (CTD = LA/LRD + 2WT) From observations of the derivatives produced by the cambium of several conifer species we measured the initial cell radial diameter (CRD0) and calculated the initial value of the state variable CA (CA0 = CTD × CRD0) The initial value of the cell-wall area (WA0) where WT0 is the primary wall thickness. All symbols with their descriptions, values and units are summarized in Table 1. A schematic representation of a tracheid and its dimensions is depicted in Figure 1 Representation of tracheid dimensions and abbreviations Data were collected from permanent plots in Italy in 2001 and in Canada from 1999–2004 Pinus cembra and Picea abies (five trees per species) were selected at tree line in the eastern Italian Alps (46°27′ N Twenty trees of Picea mariana were selected in the boreal forest of Quebec (48°13′ N having healthy crown and upright stems and lacking reaction wood The model was first developed in the SIMILE (Simulistics Ltd.) visual modeling environment to facilitate discussion within the multidisciplinary team during the implementation phases The mathematical equations were then integrated using MATLAB R2016b (the MathWorks) with a non-adaptive solver that implemented the classical Runge-Kutta method of Order 4 The equations were solved separately for each cell across the tree ring and the final outputs were then aggregated and compared with the measured tracheidograms dataset the concentration of available sugars in the cell) was assumed to be constant within each run of a single cell but it could vary between the different cells of the ring Two functions of sugar variation across the ring were tested an exponential and a quadratic curve using the following formulas: b and c are the calibration parameters and xi is the relative position of the ith cell within the ring which assumes values ranging from 0 (first cell) to 1 (last cell) Model calibration was performed by minimizing the sum of the squared errors (SSE) according to: where n1, n2 and n3 are the number of samples per observed output, WTi, LRDi, and LAi are the values of the ith measured outputs, and WTi*, LRDi* and LAi* are the values of the ith outputs predicted by the model. The minimization was performed using the fminsearch MATLAB routine that implements a Nelder–Mead simplex algorithm (Lagarias et al., 1998). The list of calibrated parameters is reported in Table 1 Figure 2. Simulated temporal dynamics of a single cell of Larix decidua exposed to either low (S = 1.58) or high (S = 2.65) sugar availability. (A,B) Temporal dynamics of simulated Cell area, Lumen area, Wall area and Lignified wall area. (C,D) Temporal dynamic of simulated Wall thickness. Light and dark gray areas represent phases of cell enlargement and wall thickening, respectively. Simulation parameters are reported in Table 1 Figure 3. Simulated and observed anatomical features of tracheids across the tree ring for different conifer species. Insets represent the correlation plots between observations (y-axis) and simulations (x-axis). Model parameters and the initial values of state variables are reported in Table 1 All simulated anatomical features across the ring were in good agreement with the measured data for the studied species, with R2 varying between 0.86 and 0.99 (Figure 3). Divergences were noted between the observed and simulated values for the first and last cells. The calculated latewood percentage in both observed and simulated tree rings also showed small differences (Table 2) Latewood percentage was underestimated in P Observed and simulated percentages of latewood in the tree rings of different conifer species cembra had an almost constant duration for cell-wall thickening across the ring with a slight increase in the last part of latewood (ranging from 20 to 23.7 days) abies showed a pronounced increase in the duration of wall thickening for ca 75% of the tree ring with values increasing from 13.2 to 39 days decidua predicted an initial increase in the duration of the thickening phase over the first half of the tree ring (from 18.7 to 30 days) then followed by a decrease (down to 13.5 days) where the duration of the phase increased slightly over the first 75% of the ring (from 22 to 24 days) with a decrease to 9.7 days toward the end of the tree ring Estimated duration (days) of cell enlargement and cell-wall thickening for the four conifer species Schematic representation of the model dynamics (A) Sugar allocation to either primary or secondary growth during the growing season (B) Cell enlargement including wall relaxation and deposition of new cellulose The expansion process stops when the increased thickness of the wall inhibits further relaxation The wall thickening and lignification continue at a rate that is inversely proportional to the cell lumen perimeter (i.e. contact surface between the cytosol and the wall) the woody cell patterns both across the tree ring and along the hydraulic pathway could both be determined by C availability during the growing season and along the tree height This can probably be explained by the fact that no direct effect of temperature was included in the model to these important auxin-mediated mechanisms occurring during the primary cell wall growth our model adds important feedbacks to the secondary cell-wall deposition processes Both cell-wall deposition and lignification rates are likely differently influenced by the contact surface between the cell wall and the lumen (i.e. showing how spatial gradients are not strictly necessary for the emergence of the typical tree-ring patterns observed in conifers inclusion of cell division and cell–cell interactions (i.e. spatial dynamics) could improve the predicted timings of cell enlargement and secondary wall deposition The presented results highlight the usefulness of focusing on the relation between basic cellular processes (e.g. cell expansion and wall deposition) and emergent properties at the tissue-scale (e.g. the model has the potential to link such processes with the effects of climatic factors to investigate the variability of wood density profiles and the appearance of intra-annual density fluctuations in Mediterranean environments SR and FG planned and designed the research under the coordination of HM and SM All authors contributed jointly to model development FG and FC carried out the mathematical implementation of the model FC and AD wrote most of the manuscript with substantial contributions from VD This work was funded by the NSERC Industrial Research Chair on Black Spruce Growth and the Influence of Spruce Budworm on Landscape Variability in Boreal Forests held by HM and by the NSERC Discovery Grant of Annie Deslauriers Using L-systems for modeling source-sink interactions architecture and physiology of growing trees: the L-PEACH model Ecophysiological implications of vascular differentiation and plant evolution CrossRef Full Text | Google Scholar Convergent tapering of xylem conduits in different woody species Widening of xylem conduits in a conifer tree depends on the longer time of cell expansion downwards along the stem Synchronism and correlations of spring phenology between apical and lateral meristems in two boreal conifers Compensatory mechanisms mitigate the effect of warming and drought on wood formation Structure and function of intra-annual density fluctuations: mind the gaps Regulation of cambial activity in relation to environmental conditions: understanding the role of temperature in wood formation of trees A rapid decrease in temperature induces latewood formation in artificially reactivated cambium of conifer stems Björklund Cell size and wall dimensions drive distinct variability of earlywood and latewood density in Northern Hemisphere conifers Brüggemann Carbon allocation and carbon isotope fluxes in the plant-soil-atmosphere continuum: a review Towards a worldwide wood economics spectrum Dynamique Intra-Annuelle de la Formation du Bois de Trois Espèces de Conifères (Sapin Pectiné Épicéa Commun et pin Sylvestre) Dans les Vosges: De la Description des Patrons Saisonniers de la Croissance à L'étude de L'influence de L'environnement sur la Cinétique du Développement Cellulaire et les Caractéristiques Anatomiques du Xylène Kinetics of tracheid development explain conifer tree-ring structure Generalized additive models reveal the intrinsic complexity of wood formation dynamics Xylogenesis: coniferous trees of temperate forests are listening to the climate tale during the growing season Intra-annual density fluctuations in tree rings: how Definition of latewood according to Mork (1928) CrossRef Full Text | Google Scholar Impact of warming and drought on carbon balance related to wood formation in black spruce Intra-annual cambial activity and carbon availability in stem of poplar The contribution of carbon and water in modulating wood formation in black spruce saplings Cellular phenology of annual ring formation of Abies balsamea in Quebec boreal forest (Canada) CrossRef Full Text | Google Scholar Lignification and lignin topochemistry - an ultrastructural view A model of stem growth and wood formation in Pinus radiata CrossRef Full Text | Google Scholar Dünser Differential growth regulation in plants-the acid growth balloon theory Studying global change through investigation of the plastic responses of xylem anatomy in tree rings “A simulation model of conifer ring growth and cell structure,” in Tree Ring Analysis: Biological Google Scholar Deficient sucrose synthase activity in developing wood does not specifically affect cellulose biosynthesis but causes an overall decrease in cell wall polymers and distribution of 14C in young Pinus resinosa trees as related to wood formation CrossRef Full Text | Google Scholar Effect of local heating and cooling on cambial activity and cell differentiation in the stem of Norway spruce (Picea abies) Gričar Regular cambial activity and xylem and phloem formation in locally heated and cooled stem portions of Norway spruce The fate and path of assimilation products in the stem of 8-year-old Scots pine (Pinus sylvestris L.) trees CrossRef Full Text | Google Scholar Seasonal change in the utilization and turnover of assimilation products in 8-year-old Scots pine (Pinus sylvestris L.) trees CrossRef Full Text | Google Scholar Modelling wood formation and structure: power and limits of a morphogenetic gradient in controlling xylem cell proliferation and growth Allocation of freshly assimilated carbon into primary and secondary metabolites after in situ 13C pulse labelling of Norway spruce (Picea abies) Hölttä A physiological model of softwood cambial growth “Effects of environment on the xylogenesis of Norway spruce (Picea abies L Karst.),” in Tree Ring Analysis: Biological Google Scholar Xylem formation can be modeled statistically as a function of primary growth and cambium activity Modelling cell wall growth using a fibre-reinforced hyperelastic–viscoplastic constitutive law CrossRef Full Text | Google Scholar storage and remobilization of 13C pulse-labeled photoassimilate in naturally growing Larix gmelinii saplings phenology and carbon storage in three coexisting deciduous tree species in a temperate forest Sucrose metabolism: regulatory mechanisms and pivotal roles in sugar sensing and plant development Convergence properties of the Nelder-Mead simplex method in low dimensions CrossRef Full Text | Google Scholar A physiological consideration of the springwood summerwood transition in red pine CrossRef Full Text | Google Scholar Contribution of different-aged needles to growth and wood formation of young red pines CrossRef Full Text | Google Scholar Critical minimum temperature limits xylogenesis and maintains treelines on the southeastern Tibetan Plateau Auxin regulates SNARE-dependent vacuole morphology restricting cell size CrossRef Full Text | Google Scholar doi: 10.1146/annurev-arplant-050213-040240 New understanding on phloem physiology and possible consequences for modelling long-distance carbon transport In situ detection of nDNA fragmentation during the differentiation of tracheary elements in higher plants cell differentiation and the localization of starch in storage tissues around the cambium in locally heated stem of Abies sachalinensis (Schmidt) Masters Coming of leaf age: control of growth by hydraulics and metabolics during leaf ontogeny Cell wall mechanics and growth control in plants: the role of pectins revisited PubMed Abstract | CrossRef Full Text Turgor pressure moves polysaccharides into growing cell walls of Chara corallina Conifer tree-ring density inter-annual variability – anatomical physiological and environmental determinants Enhancement of wall loosening and elongation by acid solutions The acid growth theory of auxin-induced cell elongation is alive and well Studies on the physiology of xylem development The effects of night temperature on tracheid size and wood density in conifers Google Scholar Trephor: a new tool for sampling microcores from tree stems CrossRef Full Text | Google Scholar Assessment of cambial activity and xylogenesis by microsampling tree species: an example at the alpine timberline CrossRef Full Text | Google Scholar Dynamic-model of lignin growing in restricted spaces CrossRef Full Text | Google Scholar The wood cell wall at the ultrastructural scale - formation and topochemical organization Actin-dependent vacuole occupancy of the cell determines auxin-induced growth repression Schiestl-Aalto CASSIA – a dynamic model for predicting intra-annual sink demand and interannual growth variation in Scots pine Intra-annual dynamics of non-structural carbohydrates in the cambium of mature conifer trees reflects radial growth demands Hormonal signals involved in the regulation of cambial activity xylogenesis and vessel patterning in trees Diel growth dynamics in tree stems: linking anatomy and ecophysiology Function and dynamics of auxin and carbohydrates during earlywood/latewood transition in Scots pine “The tracheidogram method in tree-ring analysis and its application,” in Methods of Dendrochronology “How well understood are the processes that create dendroclimatic records A mechanistic model of the climat control on conifer tree-ring growth dynamic,” in Dendroclimatology Google Scholar Growth Dynamics of Conifer Tree Rings: Images of Past and Future Environments Carbon supply and the regulation of cell wall synthesis A quantitative definition of light rings in black spruce (Picea mariana) at the Artic tree line in Northern Québec CrossRef Full Text | Google Scholar Cambial response of Norway spruce to modified carbon availability by phloem girdling Mechanism of xylem differentiation in Pinus silvestris L Google Scholar Transcriptional networks for lignin biosynthesis: more complex than we thought Mazzoleni S and Giannino F (2018) The Physiological Mechanisms Behind the Earlywood-To-Latewood Transition: A Process-Based Modeling Approach Received: 26 January 2018; Accepted: 28 June 2018; Published: 20 July 2018 Copyright © 2018 Cartenì, Deslauriers, Rossi, Morin, De Micco, Mazzoleni and Giannino. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) *Correspondence: Fabrizio Cartenì, ZmFicml6aW8uY2FydGVuaUB1bmluYS5pdA== Most of us are adrenaline junkies who use the power of that epinephrine hormone to write with the thrill of a pending deadline I can’t tell if my neurons are firing on-point or if it’s the 5-Hour Energy shots I need to keep on keeping on Every day is like drinking from a fire hose But it’s not any of that as I sit here at 5 a.m trying to muster the perfect words to come from my fingertips It’s not procrastination — or writer’s block — that stymies me I just didn’t think it would be so soon and include so many The Times will lose more than 100 years of combined journalism talent experience and institutional knowledge in the newsroom Four long-time Times journalists — Mike Bires Marsha Keefer and Jim Pane — have opted to take the company’s early retirement offering.  I’ve been searching for the appropriate words to convey what this loss means to The Times family which not only includes the remaining staff but our readers as well so many of you not only recognize their bylines but have gotten to know the people behind them allow me to share with you the people behind the names One didn’t work in newspapers in western Pennsylvania and not know the name I first met Mike in a hallway at the old Times building on Fair Avenue.  I made a wrong turn from the restroom and found myself in the advertising department I was retracing my steps when I ran right into Mike I was in awe as I chatted with the friendly and affable legend I heard co-workers talking about a mysterious employee named O.J.  “Check the time with O.J.” “Is O.J covering the game?” “Here are the photo printouts for O.J.’s story.” I finally asked then-staff photographer Sally Maxson.  I’ve heard numerous tales on how Mike got the nickname so to set the record straight and for posterity Mike in his humility barely gave me two sentences Mike got the nickname playing in a Hopewell junior varsity game at New Brighton in the fall of 1970 Simpson was a young star for the NFL’s Buffalo Bills He’s always been part of high school sports coverage during his 40-plus years at The Times In addition to covering Pitt football and basketball from 1983-1999 he was the Steelers beat reporter from 1999 to 2012 a position that also endeared him personally to the Art Rooney family.  The 1977 IUP graduate has been inducted into three Hall of Fames: Beaver County Sports Hall of Fame Pittsburgh Basketball Club Hall of Fame and Penn State Beaver Athletics Wall of Honor I’m not embarrassed to say that my husband and brother-in-law have man-crushes on Mike admiring his work and his knowledge of the region's sports The day he stopped by at their Pitt tailgating party to have a beer and food has given them infinite bragging rights.  I’m not sure which one of us is Ethel to her Lucy, but whenever Patti Conley and I get together The latter being the kind of storytelling that puts the reader right into the room with the subject Minute details and descriptions that most reporters these days don’t bother to get that make a story sing.  MORE: I got old working at a job I loved; Tuesday's 'incident' made me older, wiser by walking away The sound of tires crackling up a gravel driveway Patti is one of two writers I know whose painstaking attention to detail astounds me at every word Her gift is weaving these words into a tapestry of someone’s life She said she knew her gift for gab needed focus floods and Jack Lambert on the Steelers' sidelines as a reporter with the Kittanning Leader-Times not mine) in Happy Valley working in public information for Penn State found her way home to western Pennsylvania and started at The Times in January 1984 Like Lambert’s forearms that Patti so adored It was Patti who stayed behind with me to officially shut down the newsroom when The Times moved from its old Bridgewater location to its new digs in Hopewell Township.  We wanted one more photo on the roof with The Times sign I’ve gotten into trouble on a few occasions for going to the rooftop for photo ops with staff Each time this transgression came to light I’d get hauled into the principal’s office and quizzed on how we got up there there’s nothing that a sturdy pica pole can’t jimmy open yada … Patti and I were able to get to the roof for a final photo op We autographed and dated the ginormous blue-and-white Times sign and swore to secrecy that we will never ever tell anyone what we did until one of us retires We confessed — and that's all we have to say about that The other writer I mentioned whose words whisk me away and plop me right in the middle of the story We call her stories "Keefer Specials." There are no shortcuts to Marsha's writing I tell her "Keefer Specials" read like a 10-inch story (I've read 10-inch stories that read like 100 inches I received a card from Marsha (or as I like to tease her Marcia-Marcia-Marcia a la “Brady Bunch”) I knew there would be a beautifully written letter that would render me emotional She has a way of wording everything perfectly “I’ve said it before and still believe that ours is not a job we have the opportunity to make people think; compel them to act; uplift their spirits; cause them to laugh or cry “It’s a heavy mantle of responsibility and a profession that’s often accompanied with attacks and slurs But I wouldn’t trade it for anything I knew in seventh grade I wanted to tell stories.” Marsha’s writing earned her a plethora of top honors including the Pennsylvania NewsMedia Association’s Most Distinguished Writer of the Year Award Not only did she excel at telling stories about the people and places of Beaver County but Marsha was also responsible for making things happen in the community She was in charge of erecting a war memorial in Beaver’s Quay Square to honor Korean War veterans She built the blueprint for The Times’ first community event — See Savor food show at CCBC — which laid the groundwork for all shows to follow She established the “Growing With Books” literacy program for children from birth to age 5 and managed a pictorial history book series Always neat as a pin and impeccably dressed Marsha always reminded me of Doris Day with dark hair style and grace — and a phenomenal singing voice I would be remiss if I didn’t mention Marsha’s beloved late mother who was so proud of her daughter and her work beamed the evening Marsha accepted the state award for Most Distinguished Writer Keefer’s face as Marsha gave her acceptance speech before a crowd of 500-plus journalists in Harrisburg.  the only person in the room was her daughter Her eyes and the expression on her face were priceless but it certainly has been an incredible adventure,” she wrote It was early fall 2011 and I just finished my initial interview with the former Times executive editor when Jim Pane was called in to do follow-up scrutiny I would be reporting directly to him on the copy/design desk I don’t remember the interview — you know all the work experience stuff — because we got off on a lengthy tangent about music He geeks out on the same things I do: grammar He gets overly annoyed when The Associated Press changes its Stylebook And he can recite lines from “The Big Bang Theory” verbatim MORE: Dash-thirty-dash. Story comes to an end. Jim cut his teeth as a cub reporter but his talent for hard editing and slicing through jargon (in which a lot of officials like to speak) won out as he advanced to the copy desk A lot of people were intimidated by Jim; he’s been known to make a few reporters cry back in the day.  Jim gave no quarter for those not willing to work hard at their craft and learn from their mistakes.  tiny hand printing and vast knowledge of anything and everything I always joked that Jim wanted a breaking news story yesterday Jim oversaw a production team of copy editors and designers I often remind him that I was perfectly happy sitting in the corner cubicle editing copy and drawing boxes in InDesign Years of downsizing and outsourcing have affected the Jims of the newsrooms the stalwart keeping us steady in turbulent times He has talked me off the ledge more times than I care to admit now we got (insert the latest crisis).” To which Jim would reply with a sigh I told him to bring back some Irish luck — or just steal the Blarney Stone I’m starting to see a pattern of criminal activity at my behest.) He brought me a stone he found in Galway I think I'm going to need a bigger stone.  Some people can’t be replaced. There will never be the likes of Mike, Patti, Marsha and Jim again at The Times. I still don’t have the appropriate words, except to rip off Jim Lovell’s in “Apollo 13” before entering the Earth’s atmosphere after a thrilling once-in-a-lifetime and harrowing almost-landed-on-the-moon trip: It’s been a privilege flying with you For the five who remain in the newsroom panicking Lisa Micco is the executive editor at The Times She can be reached at lmicco@timesonline.com Interview with Lorna Shore guitarist Adam De Micco wherein we delve below the surface of Flesh Coffin into their philosophy behind the music A few weeks ago, Lorna Shore released Flesh Coffin (read our review) The album showed the band honing in on and refining their signature brand of blackened deathcore in a way we have yet to see I was able to catch up with guitarist Adam De Micco a few weeks ago when they played The Knitting Factory in Brooklyn alongside Carnifex we delved below the surface of Flesh Coffin into their philosophy behind the music as well as their riff on today’s metal scene Listening to the 45-minute epic that is Flesh Coffin it’s hard to fathom that 4 metal musicians from New Jersey pulled it off in the short span of 3 months “it was actually the most time we ever spent as a band recording new material.” Adam reveals that their previous releases were all recorded right before heading to the studio “We literally wrote 6 songs for Psalms in 4 days.” Convinced Lorna Shore were actually robots programmed to produce metal music at rapid speeds It turns out that their creative process is quite simple with Adam writing the bulk of their music: “The process starts with me writing and demoing everything Then my drummer Austin Archey comes in and we arrange songs We take time to listen to everything and make objective decisions and then put it together and record it in the studio.” While they thrive on a no-frills approach to creating music the band took it a step further on Flesh Coffin They had big goals and needed to produce an even bigger sound to match “Musically we wanted to be more aggressive We wanted to keep the listener on their toes while still making it digestible so you don’t feel lost listening to it.” Check out the band’s video for the song “Flesh Coffin” Given writing is Adam’s main focus in Lorna Shore he worked relentlessly to execute this vision for Flesh Coffin and show listeners that the band had come a long way since Psalms was released in 2015 Like any artist he is his own worst critic “Psalms felt like a smorgasbord of riffs but still have it be interesting enough so it makes sense.” “Flesh Coffin was way more thought out than before I sat in the back of the van for 6 weeks with a pen and paper critiquing every single thing I did on Psalms I analyzed everything we did to right where we went wrong but also to see where we went right and amplify that.” Austin and I sat down and conceptually figured out what kind of songs we wanted to make This meticulous level of perfectionism and preparation is clear on Flesh Coffin and each blast beat is warranted and well timed; no song is over-embellished Lorna Shore’s music is obviously influenced by bands like Behemoth their genre-bending runs deeper than the audible black metal and tech death influence Adam confessed that he draws a lot of inspiration from pop and mainstream music “I’ve been a Justin Timberlake fan since N*Sync I take a lot of influence from that and try to add it to the band in some way there is no difference between a pop star singing a catchy melody versus a metal guitarist playing it I’m able to differentiate that but still find similarities.” don’t expect there to be a pop album from Lorna Shore anytime soon When not headbanging to Obscura or singing along to Taylor Swift finding it a fresh source of inspiration for his writing “I started analyzing sheet music to figure out what these composers were doing All music is music anyway; we’re all using the same shit violin or piano – you’re still encompassing the same ideas I just try to find more ideas to pull from It’s a cool change of pace from listening to metal; it forces your brain to see things from a different perspective it’s much more enjoyable because I’m not in that realm all the time.” Lorna Shore’s recent success with Psalms and Flesh Coffin has not gone to their head—they’re still very much in awe of their success Adam discussed how he cannot fathom the fact that fans are tattooing Lorna Shore on their bodies especially when it comes to their Flesh Coffin artwork “We’ve seen the symbol on our album [Flesh Coffin] tattooed so much I just don’t see my band being that big to the point where people get tattoos even before they heard the album—what if they don’t like it?” He shared an eye-opening fan interaction where a fan got vocalist Tom Barber’s signature tattooed on his arm “Not knowing the fan would get it tattooed You can’t get an accurate signature on someone’s forearm.” Despite the band’s urging him to reconsider lo and behold Tom’s messy signature was a permanent addition to his forearm “I think it’s awesome that someone cares enough about our band to do that but I just picture bands like Slayer where fans carve ‘Slayer’ into their arm but humbling and awesome at the same time.” While Lorna Shore is not quite at Slayer status yet there is no doubt that their latest release is forging their path up the industry ladder Seeing them play less than a week after the release of Flesh Coffin it was clear that fans had avidly consumed the music already and were eager to spit back their words throughout the set slightly shocked: “I could not have asked for a better reaction.” it is that Lorna Shore is a modest band filled with passion for their music and pure gratitude for their fans Despite the highly-publicized negatives of the metal industry it’s a path Adam and the guys in Lorna Shore chose After finding himself jaded in his final months of college to pursue a degree (and a dead-end cubicle job) in accounting Adam dropped everything to pursue metal music—and he isn’t looking back “I know a lot of people talk poorly about the Internet and say it ruined music with streaming but if it wasn’t for something like that bands like Lorna Shore wouldn’t exist It gave us a platform to put out our music People from all over the world can find records from a band from NJ and there were people buying it from Indonesia or Germany This wouldn’t have existed 20 years ago.” View the “Fvneral Moon” music video Adam offered some honest tough love for metal bands—echoing within it his personal work ethic: “If your album sucks There are so many bands that sell a ton of records because they came out with a good album my first reaction is not ‘damn kids are stealing my music!’ you need to fix that.’ Make your music valuable and people will spend their money.” Flesh Coffin made it to #2 on the Billboard charts for Current Hard Rock and broke the top 5 for Overall Hard Rock and Top New Artist What’s next for the band after this run with Carnifex This is a band that prioritizes their music above all else and wants nothing more than to promote it and bring it to fans in person If you didn’t catch them this time around in the states Lorna Shore will most likely be back on the road this summer and maybe even in Europe in the not too distant future Post-Punks INVSN Preview New Album ‘The Beautiful Stories’ with Stream of “Immer Zu” FULL OF HELL Unveil Lead Track “Deluminate” off Upcoming Album ‘Trumpeting Ecstasy’ Signs Of The Swarm Detail New Album ‘To Rid Myself Of Truth’ Mike Plume Reimagines “This Is Our Home (8:30 Newfoundland)” Perturbator Releases “The Art Of War” Music Video Lockimara Releases ‘A Vision Again’ Album & New Music Video Austin Gatus Shares Live Look of “Don’t Want This to Change” feat Karolina Bnv Premieres Her Enigmatic “Unforgivable Decisions” Music Video it was like monsters with guitars and I was blown away.” Mark Morton: “I was starting to break out of the clouds I could tell that was happening and it felt really free to be creative.” Shadows of a Silhouette Premiere Energetic New Single “No Matter Where I Go” KING 810 Reveal ‘Rustbelt Nu Metal’ Album Details & European Tour Dawn Of Ouroboros Announce Extensive Spring & Summer US Tour Dates Headliner to Date at Boston’s MGM at Fenway Diablo® and Berserk Join Forces with Beast In Black for Epic Collaboration Deafheaven – ‘Lonely People With Power’ [Album Review] ©2025 V13 Media is part of V13 Media Group, owned by V13 Ventures. All rights reserved. Privacy Policy // Terms of Use Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page.