Family members are speaking out following the tragic shooting in Pembroke Park that left a mother and her three young sons dead and a fourth child and the alleged shooter hospitalized The shooting happened Wednesday night at an apartment complex in the 3100 block of W Broward Sheriff's Office deputies and officers from Pembroke Park Police and Hallandale Beach Police responded and found six people shot 2-year-old Nova McKenzie and 2-year-old Emery McKenzie were pronounced dead inside the apartment Get local news you need to know to start your day with NBC 6's News Headlines newsletter was also suffering from gunshot wounds and was rushed to a local hospital where she remained in serious condition Friday She survived quite a few gunshots," father Kelvin Solomon said Friday was also found with an apparent self-inflicted gunshot wound Stephen McKenzie is in custody at the hospital and charges are pending Cruz’s son Xion Solomon and daughter Phiinyx Solomon have a different father Family members said Xion Solomon loved football and died protecting his mother and sister "I want to make sure that anytime his name is brought up that we remember he’s a hero he died protecting his sister," Kelvin Solomon said the grandmother of Xion and Phiinyx Solomon spoke briefly with reporters about the girl's condition "She's fighting and she's gonna pull through "She needs us right now and I just want everybody to just pray for her and she'll be okay Hanson said the family is in shock over the tragedy Kelvin Solomon told NBC6 that Cruz was trying to separate from McKenzie before the shooting He said he had seen them a few days before the shooting and had a foreboding feeling that something was off with McKenzie “They kind of had a little back and forth and I tried to intervened to provide some clarity on the situation so I think they were going through a break up Sunday at the BBQ I did let her know that this doesn’t look like it’s going in the right direction," he said She said she and McKenzie's father are divorced "Very shocked about the situation," McKenzie said Deon McKenzie said she's out of town but is making her way back to South Florida to be with her children She said she last saw her stepson a little more than a year ago I wouldn't dream of seeing him doing something like this especially to the kids because he was so playful with kids he's got to be going through something," Deon McKenzie said "I don't think he reacted out of his right mind because he's really really a lover of kids." A GoFundMe has been set up for the Solomon family Tracy Lynn Cruz, known for her role as Ashley Hammond, the Yellow Ranger, in the 1990s Power Rangers series, will appear at Nova Gateway Comics and Toys uses her platform to support families facing similar challenges If you’re looking to sleep in and still get a stellar meal in downtown Fredericksburg you’re in luck—local restaurants are serving up some serious Sunday brunch vibes – A young man is dead and two juveniles are involved following a shooting during an early morning break-in just two miles from Shannon Airport A warm and sunny start to Saturday will give way to a stormy and unsettled pattern across our region this weekend Immigration and Customs Enforcement (ICE) is asking for the public’s help in locating a Jordanian national accused of attempting to breach Marine Corps Base Quantico in Virginia and Networking — Calling middle and high school students for FREE Educational Summer Programming LLT STEMpower Camp at Marymount University Read More Submit your own Community Post here Inspired by local physicians who were among the nation’s first to adopt the concierge medicine model Northern Virginia is now a hub for its surging popularity These leading physicians are redefining the patient experience with same-day appointments MD’s change to concierge medicine enabled focused attention for each individual and the launch of his innovative diet program for those with type 2 diabetes “The goal is to promote enough weight loss to reach an acceptable A1C of 6% with no medication,” he explains “Achieving that can take several months of very close follow up MD considers his patients quite literally as family “I believe there’s nothing more honorable than helping patients when they’re sick and I care for them exactly as I would my loved ones.” Whether for a specialist referral “My patients know I’m always just a phone call away.” Read More Hosted by the Obesity Action Coalition (OAC) since 2012 this highly-anticipated gathering is the nation’s leading gathering focused on empowering individuals with science-based education support and practical tools for managing weight and improving health This unique Convention truly has something Participate in the 33rd Annual Van Metre 5K Run—a race that goes further than 3.1 miles where every stride you take supports Children’s National Hospital The Van Metre 5K Run donates 100% of proceeds to Children’s National Hospital and has The latest advertising offering from the telecommunications giant reunites the "Nova Knicks" and the spot starring Mikal Bridges and Josh Hart figures to be a mainstay during commercials breaks throughout the college basketball postseason In the ad, which should prove both humorous and emotional for Knicks and Wildcats supporters, a lone DiVincenzo encounters Bridges and Hart in a basketball arena's corridor the former Cats can only share awkward greetings as the Wiz Khalifa/Charlie Puth ballad "See You Again" plays in the background we confidently guarantee our network," a voiceover says "Staying close with your college besties Not guaranteed." The scene cuts to the group celebrating DiVincenzo's birthday where the current Minnesota Timberwolf wishes he and the Knicks trio "played together forever" as he blows out the candles on a cake DiVincenzo walks away but is stopped by Brunson DiVincenzo happily dons it before a celebratory clip of the group's days as Wildcats is displayed and Hart will forever be known as March Madness legends as each played a role in Villanova's run to the 2016 men's national title and DiVincenzo were also part of the repeat run two seasons later The quartet was widely expected to reunite as Knicks this season as Bridges was acquired from the Brooklyn Nets over the summer and Hart had previously guided the Knicks to a 50-win campaign that placed them second on the Eastern Conference playoff bracket USA; Villanova Wildcats guard Jalen Brunson (1) holds the national championship trophy after defeating the Michigan Wolverines 79-62 in the championship game of the 2018 men's Final Four at Alamodome Mandatory Credit: Robert Deutsch-Imagn Images / Robert Deutsch-Imagn ImagesA Main Line revival was not to be: DiVincenzo was traded weeks before this season tipped off as the Knicks' single-season champion in successful three-pointers was one of the headlining pieces of the deal that acquired Karl-Anthony Towns from Minneapolis While Towns has mostly performed as advertised in Manhattan many Knicks fans have wondered what might've been had the team kept its full Wildcat litter This is the second straight spring to feature Brunson in a prominent marketing role: he previously repped AT&T in a 2024 spot that featured his wife Ali and fellow New York backcourt star Sabrina Ionescu. The Knicks are engaged in their own brand of March Madness as their next opportunity to close in on a playoff spot lands on Monday night against the Miami Heat (7:30 p.m Villanova missed out on the NCAA Men's Basketball Tournament but is set to partake in the inaugural College Basketball Crown Las Vegas-based consolation partly founded by Fox Sports Make sure you bookmark Knicks on SI for the latest news, exclusive interviews, film breakdowns as and so much more! GEOFF MAGLIOCCHETTIEditor-In-Chief at All Knicks The content on this site is for entertainment and educational purposes only Betting and gambling content is intended for individuals 21+ and is based on individual commentators' opinions and not that of Sports Illustrated or its affiliates All picks and predictions are suggestions only and not a guarantee of success or profit If you or someone you know has a gambling problem crisis counseling and referral services can be accessed by calling 1-800-GAMBLER Thanks for visiting The use of software that blocks ads hinders our ability to serve you the content you came here to enjoy We ask that you consider turning off your ad blocker so we can deliver you the best experience possible while you are here A man who fatally shot his estranged girlfriend and three of her young children before turning the gun on himself in Pembroke Park has died Stephen McKenzie died at a hospital on Thursday Broward Sheriff's Office officials confirmed on Monday The shooting happened Wednesday night at an apartment complex near the 3100 block of Hallandale Beach Boulevard Authorities said McKenzie fatally shot 32-year-old Julie Cruz 2-year-old Nova McKenzie and 2-year-old Emery McKenzie who survived the shooting but remains hospitalized Cruz's mother, Irma Denisse told NBC's Telemundo that her daughter had been planning to leave McKenzie and move out this weekend "I don't know if she told him she was leaving I don't know those details," Denisse said in Spanish "I asked her many times to leave him and come home Denisse spoke again outside the hospital on Monday taking him to his football practice," Denisse said For me it feels like it’s a nightmare right now." The shooting shocked the Pembroke Park community and those who know the family "Every day they would come and they were like happy kids They were little rambunctious little two-year-olds," Rivera said The dad always came and nothing seemed odd We knew that they were separated and something was going on but nothing like this Xion and Phiinyx had been students at ECB Educational K-8 Center The principal released a statement on Monday "Xion's laughter and quirky smile will forever echo in the halls of the ECB Educational Center We will remember the roaring recess football victories with your friends," the statement read Whether she gives you a friendship bracelet or an impressive art piece The motive for the shooting remains unknown Creativity knows no bounds when it comes to culinary creations, and at Kellanova we’re entering a new era with bold ambition we’re proud to welcome Chef Shari Cruz as our newest Chef in Residence Chef Cruz will use our foods to create new and compelling dishes bringing a fresh perspective and a world of culinary delights to our kitchen The Chef in Residence fellowship is a unique and exciting program that provides opportunities for talented chefs to work at the W.K Kellogg Institute for Food Technology in Battle Creek they lean into their food innovation skills collaborate with Kellanova’s culinary team and create new products that reflect diverse tastes and cultures The program has a profound purpose – to celebrate and preserve the rich culinary traditions of Black and Asian American and Pacific Islander (AAPI) communities worldwide It's more than just cooking; it's about recognizing the historical and cultural significance of food and its remarkable ability to bring people from all walks of life together Eggo meets aloha: a flavorful journey through Polynesian cuisine and culture Chef Cruz hails from the breathtaking Big Island of Hawaii with a rich heritage that includes Filipino and Chamorro roots from the Commonwealth of Northern Mariana Islands and Guam Her culinary journey is deeply rooted in her family's legacy: with family-owned businesses and a papaya farm she was surrounded by agriculture and food from an early age played a pivotal role in opening restaurants across Hawaii and Las Vegas while her mother contributed her financial expertise to the hospitality industry These influences set the stage for Shari's own culinary passion Chef Shari has an exciting lineup of projects in mind From cultural broadcasts and food hub takeovers to delicious recipes starring our iconic foods like Eggo she’ll be sharing her culinary expertise and culture in a big way She’ll also work with the Kellanova team to explore the impact of food and culture with employees As the home of iconic foods and brands like MorningStar Farms, Eggo and Pringles Kellanova wants to push beyond boundaries and across borders to create foods and brands that help to fuel the best in everyone Programs like this fellowship not only help us promote diversity in the culinary arts but also embrace new perspectives that will help us shape the future of food Sign up to receive the latest news via email The full outstanding balance of Nova's debt facility will be converted into ordinary shares of the company priced at AU$0.25 each Nova Minerals (ASX:NVA,NASDAQ:NVA) announced on Wednesday (January 8) that it has reached an agreement with Nebari Gold Fund 1 to eliminate its existing convertible debt facility The full outstanding balance of US$5.42 million will be converted into ordinary shares The deal follows Nova’s sale of its non-core investment in Snow Lake Resources (NASDAQ:LITM) for AU$10.85 million Nebari’s intent is to continue in its partner role as Nova works to unlock future value at the Alaska-based Estelle gold and critical minerals project “This conversion is a serious vote of confidence by Nebari which brings us a step closer to realizing our vision which is to concurrently develop Estelle into a tier one gold asset and to help secure a US domestic supply chain for the strategically important mineral antimony,” said Nova CEO Christopher Gerteisen in a release Nova will retain all the proceeds of the Snow Lake sale for the development of Estelle The company said that after the exercise of NASDAQ warrants over the last few ays its cash position stands at AU$16 million "Establishing a domestic source of the critical mineral antimony is more important than ever and we stand ready to responsibly produce critical resources here at home and help strengthen America’s national and economic security," Nova said Gerteisen added that the company will continue to work with Nebari in the operational phase of Estelle The conversion is set to happen on January 13 Nebari has also been involved in other transactions over the past few weeks Canadian company West Red Lake Gold Mines (TSXV:WRLG,OTCQB:WRLGF) announced on January 2 that it has entered into a completed credit agreement with Nebari to borrow up to US$35 million The companies first entered into a non-binding term sheet in October 2024 In addition, gold producer Lion One Metals (TSXV:LIO,OTCQX:LOMLF) entered into an agreement with Nebari to amend certain terms and draw down a further US$4 million of its senior secured financing facility along with the company’s updated financial results Don’t forget to follow us @INN_Australia for real-time news updates hold no direct investment interest in any company mentioned in this article Get the trends and expert predictions you need to stay ahead of the markets Learn About Exciting Investing Opportunities in the Precious Metals Sector Gabbie graduated with a journalism degree from Colegio de San Juan de Letran - Manila and has produced articles on a variety of topics Her creative portfolio includes written work on architecture Gabbie covers the Australian market for the Investing News Network exploring the international coffee culture and fighting for queer rights Investing News Network websites or approved third-party tools use cookies. Please refer to the cookie policy for collected data Writer Learn about our editorial policies. This website is using a security service to protect itself from online attacks. The action you just performed triggered the security solution. There are several actions that could trigger this block including submitting a certain word or phrase, a SQL command or malformed data. You can email the site owner to let them know you were blocked. Please include what you were doing when this page came up and the Cloudflare Ray ID found at the bottom of this page. Empty PLGA and PLGA(RGF) nanoparticles were prepared using the microfluidic method, followed by the DOTA and CXCR4L functionalization and nanoparticle radiolabeling with 177Lu. The final nanosystem gave a particle size of 280 nm with a polydispersity index of 0.347. In vitro and in vivo toxicity effects were assessed using the HCT116 colorectal cancer cell line. 177Lu-PLGA(RGF)-CXCR4L nanoparticles decreased cell viability and proliferation by inhibiting Erk and Akt phosphorylation and promoting apoptosis. Moreover, in vivo administration of 177Lu-PLGA(RGF)-CXCR4L significantly reduced tumor growth in an HCT116 colorectal cancer xenograft model. The biokinetic profile showed hepatic and renal elimination. Data obtained in this research justify additional preclinical safety trials and the clinical evaluation of 177Lu-PLGA(RGF)-CXCR4L as a potential combined treatment of colorectal cancer. Volume 10 - 2023 | https://doi.org/10.3389/fmed.2023.1191315 This article is part of the Research TopicRecent Advances in Nanoradiopharmaceuticals for Molecular Imaging and RadiotherapyView all 4 articles Introduction: More than 1.9 million new cases of colorectal cancer and 935,000 deaths were estimated to have occurred worldwide in 2020 Therapies for metastatic colorectal cancer include cytotoxic chemotherapy and targeted therapies in multiple lines of treatment the optimal use of these agents has not yet been resolved Regorafenib (RGF) is an Food and Drug Administration (FDA)-authorized multikinase inhibitor indicated for patients with metastatic colorectal cancer non-responding to priority lines of chemotherapy and immunotherapy Nanoparticles have been used in specific applications such as site-specific drug delivery systems C-X-C Chemokine receptor type 4 (CXCR4) is the most widely-expressed chemokine receptor in more than 23 human cancer types This research aimed to synthesize and preclinically evaluate a targeted nanosystem for colorectal cancer chemo-radiotherapy using RGF encapsulated in Poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles coated with a CXCR4 ligand (CXCR4L) and 177Lu as a therapeutic β-emitter Methods: Empty PLGA and PLGA(RGF) nanoparticles were prepared using the microfluidic method followed by the DOTA and CXCR4L functionalization and nanoparticle radiolabeling with 177Lu The final nanosystem gave a particle size of 280 nm with a polydispersity index of 0.347 In vitro and in vivo toxicity effects were assessed using the HCT116 colorectal cancer cell line Results: 177Lu-PLGA(RGF)-CXCR4L nanoparticles decreased cell viability and proliferation by inhibiting Erk and Akt phosphorylation and promoting apoptosis in vivo administration of 177Lu-PLGA(RGF)-CXCR4L significantly reduced tumor growth in an HCT116 colorectal cancer xenograft model The biokinetic profile showed hepatic and renal elimination Discussion: Data obtained in this research justify additional preclinical safety trials and the clinical evaluation of 177Lu-PLGA(RGF)-CXCR4L as a potential combined treatment of colorectal cancer This research aimed to synthesize and preclinically evaluate a bifunctional system of targeted chemo-radiotherapy for colorectal cancer using RGF encapsulated in PLGA nanoparticles coated with 177Lu and CXCR4L The chemo-radiotherapy combination of the 177Lu-PLGA(RGF)-CXCR4L nanosystem is expected to improve therapeutic response in colorectal cancer models nca > 3,000 GBq/mg) as 177LuCl3 2-(1H-7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate (HATU) and all other reagents were of analytical grade The 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide; XTT) reagent was obtained from Roche Diagnostics (Indianapolis and the HCT116 cell line was obtained from ATCC (Atlanta Schematic representation of the 177Lu-PLGA(RGF)-CXCR4L synthesis for combined therapy (A) Microfluidic device (Droplet Junction Chip) (B) Synthesis of PLGA-entrapped RGF nanoparticles (C) Functionalization of PLGA nanoparticles with CXCR4L (D) Functionalization of PLGA(RGF)-CXCR4L nanoparticles with DOTA (E) Radiolabeling of DOTA-PLGA(RGF)-CXCR4L with 177Lu For selecting the optimal formulation to produce stable PLGA nanoparticles loading RGF [PLGA(RGF)], Design-Expert 11.1.2.0 software was employed. A randomized factorial study without blocks was carried out with a D-optimal design and a reduced 2FI model. Thirty-six experiments were carried out, including four factors: Factor A (PVA 0.25, 0.50, and 1.00%), Factor B (RGF concentration at three levels: 0.50, 0.75, and 1.00 mg/mL), Factor C (PLGA 10 mg/mL) (17) flow rate: two levels (PLGA: 50 and 100 μL/min) and Factor D (PVA Flow Rate: 1,000 and 2,000 μL/min) ζ potential and polydispersity index (PDI) were measured by Dynamic Light Scattering (DLS) some selected nanosuspensions were evaluated for stability at room temperature for 2 weeks Subsequently, from optimized conditions PLGA and PLGA(RGF) nanoparticles were prepared using the droplet junction chip for providing the aqueous PVA 0.5% solution through two peripheral channels, while PLGA dissolved in acetone (10 mg/mL) was injected into the central channel of the device (Figure 1) The obtained nanosuspension was filtered by ultracentrifugation (MW Cutoff CO 30 kDa and stored in a B-type glass vial with an elastomer stopper and aluminum seal for further analysis Resuspended samples with a 0.5% PVA solution (3 h thermo shaker) were evaluated for hydrodynamic diameter FT-IR characterization was performed using a freeze-dried formulation The quantification was performed using a RGF standard curve (0.08–1.0 mg/mL The RGF loading capacity was calculated as the amount of RGF divided by the total weight of the nanoparticles The RGF loading efficiency was calculated as the amount of RGF divided by the added RGF To activate -COOH groups of PLGA for further conjugation to the amine group of p-NH2-Bn-DOTA (DOTA) or hidrazyne moiety from HYNIC included in the CXCR4L structure 10 μL of a solution containing 50 mg of the carboxylate activating agent HATU [in a basic media with DIPEA (10 μL) and DMF (200 μL)] The reaction mixture was incubated for 15 min at 37° C and was added to the PLGA and PLGA(RGF) solutions [1 mg/mL in 0.25% PVA (v/v)] For the conjugation of DOTA and CXCR4L to the empty PLGA and PLGA(RGF) nanoparticles 5 μL of 0.02 M HCO3− (pH 9.0) 100 μL of 0.5% PVA (w/v)] and CXCR4L [1 mg CXCR4L in 100 μL of 0.5% PVA(w/v)] was prepared and added to the previously-activated carboxylate PLGA nanoparticle solution The mixture was incubated at 37° C for 90 min and DOTA-PLGA(RGF)-CXCR4L were purified by ultracentrifugation (Ultra Centrifugal filters MWCO 30,000 Da; Millipore; 16,000 g) until neutral pH was achieved each filtrate was resuspended in PVA (0.5% w/v) The bifunctional chelator DOTA was the radiolabeling site for the different PLGA nanoparticles using acidic conditions for the 177Lu complexation reaction 9.25 MBq (50 μL) of 177LuCl3 in 1 M acetate buffer (pH 5.0) was added to each PLGA nanoparticle system: DOTA-PLGA(RGF)-CXCR4L and incubated for 1 h at 37° C the nanoparticles were purified by ultracentrifugation (Ultra Centrifugal Filters MWCO 3,000 Da; Millipore; 2,500 g) Both fractions (filtered and unfiltered) were measured in a dose calibrator (Capintec United States) to calculate the radiolabeling yield The radiochemical purity of PLGA nanoparticles was evaluated by size-exclusion high-performance liquid chromatography (HPLC) and Instant Thin Layer Chromatography with Silica Gel (ITLC-SG) The particle size distribution and ζ potential analyses were carried out via Dynamic Light Scattering (DLS) The studies were performed in an aqueous solution with a wavelength of 657 nm (20°C and a sampling time of 128 μs) The mean diameter and standard deviation for each sample were reported (n = 3) ζ potential was measured in diluted samples to ensure adequate and constant ionic strength The morphological features of PLGA nanoparticles were observed by TEM in a JEOL JEM 2010 HT instrument (JEOL; Japan) A drop of the samples was placed onto a carbon-coated copper grid and evaporated under a vacuum before measurements IR spectra of raw materials and lyophilized samples were obtained on a Perkin Elmer System 2000 spectrometer with an ATR platform (Pike Technologies) Fourier Transform Infrared (ATR-FT-IR) spectroscopy The spectra were acquired with 50 scans in an operating range of 4,000–400 cm−1 and a resolution of 0.4 cm−1 Absorption spectra were obtained with a Perkin Elmer Lambda Bio spectrometer the nanoparticle suspensions were measured by UV–Vis spectroscopy to monitor the conjugation reactions The lyophilized nanoparticles were reconstituted in PVA (0.5% w/v the content of a vial solution (n = 3) was kept at room temperature at different time points (1 The particle size distribution and ζ potential were measured Several vials containing 1 mg/mL of DOTA-PLGA(RGF)-CXCR4L were stored at 4°C for 1 year to evaluate long-term stability To assess 177Lu-PLGA(RGF)-CXCR4L and 177Lu-PLGA(RGF) cell uptake a solution containing 1 × 106 HCT116 cells diluted in 1 mL of fresh medium was added to a glass tube and incubated with 10 μL (3.3 MBq) of 177Lu-PLGA(RGF)-CXCR4L and 177Lu-PLGA(RGF) at 37°C for 30 min cells were washed twice with PBS solution and counted in a gamma counter The internalized fraction of conjugates was calculated after eliminating the membrane-bound radioactivity by incubating cells with 1 mL of CH3COOH/NaCl (0.2 M/0.5 M) for 2 min washing them with PBS and counting the cell pellet The initial activity of each treatment was considered to be 100% it was decided to use half the IC50 concentration of the RGF-resistant cells the cells were incubated with 50 μL (3 Bq/cell 7.26 μM of RGF) of each treatment as follows: (1) Control (without treatment) The viability was evaluated at 24 h after treatment exposure The spectrophotometric measurement of each well at 450 nm in a microplate absorbance reader (EpochTM; BioTek Instruments; United States) was performed to determine cell viability The absorbance from untreated cells was considered 100% of viability HCT116 cells were used to evaluate the ability of a single cell to grow into a colony after exposure to a specific treatment Cells (400–500 cells) were seeded in each well (six-well plate) and treated with 3 Bq/cell (RGF 7.26 μM) of (1) Control (without treatment) and (8) 177Lu-PLGA(RGF)-CXCR4L dissolved in 1.5 mL of growth medium The controls were comprised of 400–500 cells exposed to the growth medium for 48 h the treatments or medium were removed and replaced with fresh medium The plates were incubated for 15 days Surviving colonies were fixed for 10 min with 4% paraformaldehyde at room temperature and washed with type 1 water they were stained with 0.1% crystal violet for 30 min 10% acetic acid was added for 5 min to extract the crystal violet and the absorbance was measured at 590 nm in a microplate absorbance reader (EpochTM; BioTek Instruments; United States) Cell samples were transferred to a microcentrifuge tube and lysed using Tissue Cell Lysis Buffer (CAT No: GB-181-100) After centrifugation at 20,000 × g for 15 min and protein quantification SDS-PAGE was carried out using 30 μg of protein in each sample proteins were transferred onto PVDF membranes (Merck Millipore) and blocked for 1 h at room temperature using PBS containing 5% bovine serum albumin (BSA) Antibodies used for western blotting were total pERK1/2 (Thr202/Tyr204; D13.14.4E; Cell Signaling-4370 1:1,000) pAkt (Ser-473; D9E; Cell Signaling-4060 1:500) Primary antibodies were incubated overnight at 4°C and washed off Species-specific HRP-conjugated secondary antibodies were then incubated for 1 h at room temperature and washed extensively membranes were incubated with Super Signal West Femto substrate (Thermo Fisher Scientific) and signals were detected using the in vivo Xtreme imaging system (Bruker Apoptosis in the HCT116 cell line was detected with the Muse™ Caspase-3/7 kit cells were seeded in cell culture flasks at a density of 1 × 106 cells and exposed to 7.26 μM of RGF via the PLGA(RGF)-CXCR4L and PLGA nanosystems and free RGF for 24 h Untreated cells were used as the control group cells were trypsinized and suspended in 50 μL of 1X Assay Buffer BA (1 × 106 cells/mL) Then 5 μL of Caspase-3/7 reagent working solution was added to each cell suspension The suspension was then gently vortexed and incubated at 37°C with 5% CO2 for 30 min 150 μL of Caspase 7-AAD working solution was added to each tube Fluorescent intensities were examined by flow cytometry using a Muse Cell Analyzer (Merck Millipore; Burlington United States) and were conducted in triplicate The 177Lu-PLGA(RGF)-CXCR4L nanoparticle system was injected intravenously into the healthy BALB/c mice (100 μL The mice (n = 3) were sacrificed at 1 and spleen were rinsed and placed into pre-weighed plastic test tubes The activity was determined in a well-type scintillation detector (Canberra) along with six 0.5 mL aliquots of the diluted standard representing 100% of the injected activity Mean activities were used to obtain the percentage of injected dose (%ID) at different times The mean percentage of injected activity at 1, 3, 24, 48, and 144 h (%ID, n = 3 for each time point) of the liver, kidney, lung, and spleen were introduced into the Olinda/EXM computer code to obtain the 177Lu-PLGA(RGF)-CXCR4L time activity versus time function [Ah (t)], corrected by decay (λe = λB + λR), for each organ (Equation 1) The integral of each time-activity curve represents the total number of nuclear transformations (N, MBq.h/MBq) of 177Lu in the source regions (Equation 2) The absorbed doses delivered by 177Lu-PLGA(RGF)-CXCR4L to selected organs were estimated based on the following general equation (3): Dtarget ← source is the mean absorbed dose to the target organ from a source organ and DFtarget ← source is a dose factor that considers the fraction of absorbed energy for each nuclear emission of Lutetium-177 in the different geometries and chemical compositions of the organs Lutetium-177 DF values for a 25-g mouse model were obtained from the Olinda code the tumor volumes were normalized to 1 in order to report the relative tumor volume and kidneys were extracted for histological assessment 12 mice were also inoculated with 1 × 106 HCT116 cells When tumors reached 150 mm3 (~14 days) mice were randomly assigned to four groups Mice were monitored daily to register mortality for 70 days Images were obtained from mice with the in vivo Xtreme imaging system (Bruker mice were anesthetized during radiopharmaceutical administration and image acquisition with a mixture of isoflurane (2%) and oxygen The X-ray images were acquired using a voltage of 45 kVp a current of 497 μA and an aluminum filter of 0.8 mm binning was set at 1 × 1 and the field of view (FOV) was 12.5 cm Radioisotopic images were acquired with an ultrathin uniform radioisotopic phosphor screen and a parallel-hole collimator with a binning of 4 × 4 and a FOV of 12.5 cm Reflectance images were acquired using a standard exposure and the high-velocity mode binning 1 × 1 and a FOV of 12.5 cm Radiation absorbed dose of tumors were estimated after 24 h post-injection of 177Lu-PLGA(RGF) or 177Lu-PLGA(RGF)-CXCR4L from radioisotopic images Paraffin sections of colon tumor samples were deparaffinized in xylene and rehydrated in a series of graded alcohols The antigen was retrieved in 0.01 M EDTA-Tris buffer Samples were incubated in 0.9% H2O2 for 5 min followed by 1 h of blocking in 1% BSA in PBS slides were incubated for 1 h at room temperature with anti-Ki67 (1:100; BIOCARE Medical) washed and set in MACH1 Universal HRP-polymer for 1 h at room temperature samples were developed with Betazoid DAB Chromogen counter-stained with hematoxylin and mounted with synthetic resin solution and lungs were fixed in 4% formaldehyde for 24 h at room temperature Tissues were sectioned and stained with hematoxylin and eosin (H&E) using standard protocols Images were acquired using a Motic AE 2000 microscope (MI01MICRLP) equipped with a Moticam 5.0 MP digital camera The significance between treatments was analyzed quantitatively via a two-way ANOVA using GraphPad Prism software % of apoptotic cells and relative tumor volume results were reported as the mean value and standard error of the mean (SEM) significance was evaluated by performing the Student’s test (significance p < 0.05) a new nanoparticle system based on Regorafenib (RGF) was designed and synthesized as a chemotherapeutic agent entrapped in PLGA nanoparticles 177Lu was used as the radiotherapeutic component to produce a synergistic anticancer effect specifically targeted for cancer cells through the CXCR4 ligand Influence of the selected factors for the optimal nanoparticle formulation PLGA nanoparticles were produced via a microfluidic device and 1.5% w/v) concentration and controlling the flow rates of the continuous and dispersed phases The flow rates oscillate between 50/1,000 and 100/1,000 (organic/aqueous phases) Three batches were prepared and the stability was followed by measuring the hydrodynamic diameter and z potential The RGF loading was performed via microfluidics during the preparation of PLGA nanoparticles Since the ζ potential was favored by RGF concentration the optimal preparation condition was set at 0.5 mg/mL which was also the formulation that exhibited colloidal stability for 2 weeks The RGF entrapment efficiency of PLGA(RGF) was 91.46 ± 0.47% (n = 3) calculated from the HPLC linear fitting (y = 5.2007E7–2.038E6 The entrapment efficiency of RGF onto DOTA-PLGA(RGF)-CXCR4L was 91.58 ± 0.22% (n = 3) it was observed that controlling and monitoring the colloidal stability during functionalization is a useful strategy to avoid the irreversible aggregation and changes in the polymeric matrix To evaluate the effect of adding molecules to the polymeric systems, the morphology, size, and distribution were analyzed via TEM and DLS, respectively. The TEM micrographs showed adequate dispersion of nanoparticles with spherical shape. Furthermore, during the surface modification of nanoparticles (Figure 1), there were no morphological differences (Figures 3A–C) Morphology and size of the nanoparticle system TEM micrographs and hydrodynamic distribution of (A) The mean hydrodynamic diameter of PLGA and PLGA(RGF) nanoparticles was 129.7 ± 50.2 and 141.9 ± 77.0 nm, respectively (Table 1) with a wide distribution of an apparent monomodal population [PDI = 0.263 for PLGA and 0.559 for PLGA(RGF)] RGF loading allowed an increase in hydrodynamic diameter (in an aqueous solution) which was attributed to the rearrangements in the inner polymer due to the RGF encapsulation The hydrodynamic diameter measurement of conjugated systems was higher than that obtained for PLGA and PLGA(RGF) The increase in hydrodynamic diameter was due to the presence of DOTA or both on the surface of the PLGA nanoparticle The comparative infrared spectrum of individual components: (A) PLGA NPs The infrared spectrum corresponding to the final system DOTA-PLGA(RGF)-CXCR4L, showed each component’s contribution of characteristic vibrations. The increased and centered region at 3,300 cm−1 is assigned to the amines present in the macrocycle, while the ester region displayed and increased confirmed the presence of CXCR4L and DOTA (Figure 4F) UV–Vis optical density normalized spectra of: (A) PLGA The radiolabeling efficiency was evaluated through radiochemical purity for all the intermediates and the final system. The 177Lu-PLGA (Figure 6A), 177Lu-PLGA-CXCR4L (Figure 6B), 177Lu-PLGA(RGF) (Figure 6C), and 177Lu-PLGA(RGF)-CXCR4L (Figure 6D) radiochemical purity was >99% as evaluated by size-exclusion HPLC (MeOH:ACN:H2O 60:20:20 v/v) with a flow rate of 2 mL/min The retention time was 3.1–3.3 min using the same mobile phase (Rf = 0 for 177LuCl3 and Rf = 0.8 for 177Lu-PLGA No differences in retention time were observed among the intermediates which is attributed to the relatively small changes in molecular weight of the final system resulting from the binding of CXCR4L (837 g/mol) or DOTA (568 g/mol) molecules on the total surface of the nanoparticle (approximately 250 kDa Size-exclusion radio-HPLC chromatogram of (A) 177Lu-PLGA The radiochemical purity of 177Lu-PLGA(RGF)-CXCR4L was also corroborated by ITLC-SG using NaCl (0.9%): 0.2 M HCl (Rf = 1.0 for 177LuCl3) using MeOH:ACN:H2O 60:20:20 v/v as mobile phase which demonstrated that this radiopharmaceutical could be prepared from a lyophilized formulation and be kept in solution 5 h after preparation (A) Hydrodynamic diameter of DOTA-PLGA(RGF)-CXCR4L at 1 Radiochromatogram of 177Lu-PLGA(RGF) after radiolabeling (B) Radiochromatogram of 177Lu-PLGA(RGF)-CXCR4L after radiolabeling (D) The presented results allow us to assume that the nanoradiopharmaceutical formulation remains stable at 4–8°C in its sealed container system (Type B glass container with elastomeric stopper −20 mm-and aluminum seal) for at least 1 year for further reconstitution Comparison of (A) cell uptake and (B) internalization of 177Lu-PLGA(RGF) and 177Lu-PLGA(RGF)-CXCR4L nanoparticle systems after incubation of 1 and 24 h (*p < 0.01 **p < 0.001) in HCT116 colorectal cancer cells Since, the uptake and internalization of nanoparticles sizing 100 nm are taken up into the cells more efficiently than those with dimensions of 50, 200, 500, and 1,000 nm (34), CXCR4L-targeted nanosystems could be uptaken through receptor-mediated endocytosis and untargeted nanoparticles through the caveolin-mediated endocytic pathway (35) the combined effect of chemo-radiotherapy and the 177Lu-PLGA(RGF)-CXCR4L system significantly decreased the activation (Thr202/Tyr204 phosphorylation) of pErk1/2 Combined chemo-radiotherapy with the 177Lu-PLGA(RGF)-CXCR4L nanosystem inhibits cell survival and proliferation of HCT116 cancer cells through a decrease of Akt and Erk activation (A) The colorectal cancer cell line HCT116 was treated with 177Lu-PLGA(RGF)-CXCR4L and its respective controls for 24 h (RGF at a concentration of 7.26 μM and 20 μCi of 177Lu) (B) Cells were treated with 177Lu-PLGA(RGF)-CXCR4L and its respective controls in a clonogenic assay; blue-violet colonies are viable cells Representative images of the clonogenic assay of three independent experiments are shown Quantification of crystal violet staining from HCT116 cancer cells depicted in (C) n = 3 ***p < 0.0001 (D) WB-analyzed cell lysates for phosphorylation levels of pErk1/2 Representative blots of three independent assays are shown PLGA(RGF)-CXCR4L increase the percentage of apoptotic/dead cells 24 h after treatment (A) Percentage of HCT116 colorectal cancer cells in apoptotic [Caspase-3/7 (+) and 7-AAD (−)] and Late Apoptotic/Dead [Caspase −3/7 (+) and 7-AAD (+)] (B) Caspase −3/7 and 7-AAD analysis of HCT116 cells treated with PLGA(RGF)-CXCR4L for 24 h Biokinetic profile of 177Lu-PLGA(RGF)-CXCR4L [Ah (t)] in BALB/c mice after intravenous administration These results also correlated with the radiation absorbed dose in the tumor (1.12 Gy/MBq) if compared with 0.37 Gy/MBq in the kidney or 0.09 Gy/MBq produced in the liver The targeted nanosystem showed increased uptake in the kidney and liver at 1 h. In the lung and spleen, the average percentage of injected radioactivity (%IA) of 177Lu-PLGA(RGF)-CXCR4L decreased in parallel. The kidney was the organ that received the highest radiation dose per MBq of radioactivity administered (0.37 Gy); the liver received 0.09 Gy; the lungs and spleen received 0.02 Gy (Table 2) Since CXCR4 is also overexpressed in hematological, breast, esophageal, head and neck, renal, lung, gynecologic, liver, prostate, and gallbladder cancers (47) 177Lu-PLGA(RGF)-CXCR4L would also be a potential nanoapproach to treat these malignancies at the clinical level Both nanosystems display similar tumor uptake which corroborates the highest inhibition of subcutaneous xenograft colorectal tumor with 177Lu-PLGA(RGF) and 177Lu-PLGA(RGF)-CXCR4L nanosystems Therapeutic in vivo efficacy of the 177Lu-PLGA(RGF)-CXCR4L nanosystem (A) Twice -intravenously-administered treatments reduce the tumor size in murine colorectal cancer xenografts compared to free RGF and control (untreated) n = 3; ***p < 0.001 (B) Survival rate for each experimental group (C) Representative images of immunohistochemical staining for Ki67 (a marker of proliferation) in the xenograft tumor tissues Xray and Radioisotopic images of mice treated with the (A) 177Lu-PLGA(RGF) system and (B) 177Lu-PLGA(RGF)-CXCR4L system 24 h post-administration of 2.4 MBq The liver and kidney uptake was subtracted from the image to visualize the tumor uptake Nanosystems have three retention mechanisms in healthy tissues The first is phagocytosis through the reticuloendothelial system [nanoparticles uptake by liver macrophages (Kupffer cells)] and spleen macrophages The second one is the fast accumulation in the tumor stroma (tumor microenvironment) through the enhanced permeability and retention (EPR) effect The EPR effect initially takes advantage of the endothelial intercellular space size (from 400 nm up to 800 nm) of tumors (where nanoparticles easily cross and accumulate) compared to 2 nm in normal/healthy endothelial cells 177Lu-PLGA(RGF)-CXCR4L nanoparticles are also retained by the third mechanism data suggest that intravenously-administered 177Lu-PLGA(RGF)-CXCR4L and 177Lu-PLGA(RGF) nanosystems do not lead to systemic toxicity or side effects and lung histopathology after 14 days of treatment of RGF 177Lu-PLGA(RGF) and 177Lu-PLGA(RGF)-CXCR4L Mitotic forms (red arrow); atypical nuclei (black arrow) The 177Lu-PLGA(RGF)-CXCR4L nanoparticle system was designed based on the combination of specific chemotherapy provided by RGF and targeted radiotherapy The nanoparticle system showed a synergistic effect capable of reducing the viability and proliferation of the HCT116 colorectal cancer cell line and significantly decreasing tumor growth of the colorectal cancer xenograft model The preparation of 177Lu-PLGA(RGF)-CXCR4L from a lyophilized formulation makes this formulation a good candidate to be produced in a GMP-grade facility for clinical translation The data obtained in this research justifies additional preclinical safety trials and clinical evaluation of 177Lu-PLGA(RGF)-CXCR4L nanosystem as a potential combined treatment of colorectal cancer Further evaluation regarding the preclinical therapeutic efficacy of 177Lu-PLGA(RGF)-CXCR4L nanoparticles should be performed to demonstrate their clinical potential The original contributions presented in the study are included in the article/Supplementary material further inquiries can be directed to the corresponding author The animal study was reviewed and approved by Institutional Animal Care and Use Committee of the National Institute of Nuclear Research (ININ) All authors contributed to the article and approved the submitted version This study was supported by the Consejo Nacional de Ciencia y Tecnología (CONACyT A1-S-38087) and was carried out as part of the activities of the “Laboratorio Nacional de Investigación y Desarrollo de Radiofármacos PC-N acknowledges the Consejo Mexiquense de Ciencia y Tecnología del Estado de México (COMECyT) for the postdoctoral CAT2021-0036 grant The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher The Supplementary material for this article can be found online at: https://www.frontiersin.org/articles/10.3389/fmed.2023.1191315/full#supplementary-material Factors associated with the survival of colorectal cancer in Mexico Treatment sequencing in metastatic colorectal cancer CrossRef Full Text | Google Scholar CrossRef Full Text | Google Scholar Regorafenib in the treatment of metastatic colorectal cancer CrossRef Full Text | Google Scholar Evolving role of regorafenib for the treatment of advanced cancers Mcl-1 inhibition overcomes intrinsic and acquired regorafenib resistance in 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This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) distribution or reproduction in other forums is permitted provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited in accordance with accepted academic practice distribution or reproduction is permitted which does not comply with these terms *Correspondence: Brenda Gibbens-Bandala, YnJlbmRhLmcuc2VydmljaW9zQGluaW4uZ29iLm14; Blanca Ocampo-García, YmxhbmNhLm9jYW1wb0BpbmluLmdvYi5teA== Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher 94% of researchers rate our articles as excellent or goodLearn more about the work of our research integrity team to safeguard the quality of each article we publish 2024 at Madison Square Garden in New York City Foster will defend his WBC junior lightweight title against Abraham Nova on Feb 16 at The Theater at Madison Square Garden O'Shaquie Foster speaks at a press conference on Wednesday O'Shaquie Foster (left) and Abraham Nova (right) square off at a press conference on Wednesday Foster will defend his WBC junior lightweight title against Nova on Feb That victory included a furious rally by Foster, an action-packed 11th round that Ring Magazine called the best round of 2023 and a stoppage victory in the fight’s final minute The late-round slugfest was a stark contrast to how Foster who grew up in Orange and lives in Houston won the title in February 2023 at San Antonio’s Alamodome where he put on a technical boxing clinic in a unanimous decision victory over Rey Vargas who was undefeated at the time and stepping up a division to try to claim a title in his third weight class FROM ORANGE TO HOUSTON: The long road boxer O’Shaquie Foster has traveled to world title fight “I think I did it so easy and smooth that people just kind of took it for granted he just beat a smaller guy' or whatever,” Foster said before a recent training session at downtown Houston’s Main Street Boxing it showed them that the power is there from one through 12 (rounds) I’ve got everything that comes with the sport With that respect came a new promotional contract with Top Rank that will put the 30-year-old Foster (21-2 12 KOs) in front of the world on ESPN three times a year including Friday night when he defends his World Boxing Council junior lightweight title against Abraham Nova (23-1 16 KOs) at The Theater at Madison Square Garden (8 p.m O'Shaquie Foster (left) and Abraham Nova (right) at a press conference on Wednesday Foster’s previous title fights have come on Showtime and streaming service DAZN so this will be his first time on ESPN and his first trip to Madison Square Garden in any capacity “Fighting on ESPN definitely makes it easier for my people to see it because pretty much everyone has it,” Foster said I look at it as a chance to fight in front of people that maybe don’t really follow boxing I plan on putting together an impressive showing and winning over a lot of fans.” Officials at Top Rank and ESPN will have their fingers crossed their plan is for Foster to continue to grab prime-time slots on the cable network a fight against one of the other champions at 130 pounds — Foster specifically points to the possibility of facing World Boxing Association titleholder Lamont Roach Jr Foster says he’d like to eventually move up to 135 or 140 pounds where some of the sport’s biggest names roam he has hopes of unifying the belts in his current weight class but he’s had trouble getting other titleholders like Emanuel Navarrete and Joe Cordina to agree to deals “They get the belt and then they want to see how long they can keep it then we can do something with the belt.' I just don’t think like that you have to do great things and the challenges have to be there but if I stay beating these guys and stay in the fans' face After suffering two upset defeats as a 22-year-old the former amateur champion fell off everyone’s radar Foster says he specifically called out Nova but was rebuffed and told his “name wasn’t big enough” to challenge the Puerto Rican who started his career with 21 straight wins “It’s crazy how the tables have turned and now you have to come to me to fight since I’m the champion,” Foster said With Foster already having won over boxing promoters thinks his fighter is set to build on his breakout title defense from October “That’s just who he is,” Benton said of the performance in Mexico “People haven’t even seen what he’s capable of doing he’s got the chance to show a big audience and do it three times a year that’s how Foster is viewing his first trip to Madison Square Garden A win is needed to get bigger and bigger fights but he wants more than just his hand raised at the end of the night “We’re going to do everything we can to make it a dominant night “We’re going to leave New York and come back home with more fans and keep going from there.” Matt YoungTrending Sports ReporterMatt Young is a trending sports reporter at the Houston Chronicle. He can be reached at matt.young@houstonchronicle.com. Matt has been a sports editor/writer at the Chronicle since 2015. He's proudly from Alief and occasionally sits alone in his four-cornered room staring at candles. WEST PALM BEACH, Fla. — As families of the Parkland victims sat in the courtroom shocked and saddened by the life sentences for Nikolas Cruz some legal experts said it didn't surprise them Despite the expectations of many of the Parkland victims' parents legal scholars point out that the country has been moving away from the death penalty Law professor Bob Jarvis at Nova Southeastern University and other attorneys point out that there may have been several factors that led to the jury not recommending the death penalty RELATED: What's next for Nikolas Cruz after life sentence? "This was a case taking place in Broward County Broward County is a very liberal county," Jarvis said pointing out that Nikolas Cruz's defense team only had to convince one juror to vote for a life sentence "The death penalty is becoming less and less acceptable to Americans." Miami defense attorney David Weinstein said the Parkland gunman's lawyers may have decided they had a read on the jury on the day they suddenly ended their defense which was a move that had angered the judge "They knew through their defense case when it was halfway through they've done enough and there was no reason to keep putting any more witnesses on," Weinstein said "They saw something that they connected with in one of those jurors that made them believe we've got one." Finding that one juror who couldn't vote for death seemed to be an easier task than convincing all 12 to vote for death "They make connections with you through eyes the way they look at your witnesses and you have to gage based on your gut It's not known if any jurors had any deeply hidden objections to capital punishment but there were other clues as to how some would understand the defense of mental illness who either had experience with the mental health counseling system or had secondhand experience with it and who felt it had helped them," Jarvis said "It's a system that we have to live with the result from," Weinstein said "We can't just throw it out because it didn't give us the result that we thought would happen or that we hoped would happen." It's certainly not the result the families of the Parkland victims had wanted both legal experts said the life sentence does spare the families years — maybe even decades — of the anguish of returning to courtrooms for death penalty appeals staff and students from PUCRS and UFRGS participated in activities at the British institution The month of October marks the end of the Women in Science project conducted in partnership by King’s College London The project featured movie sessions debated by researchers mentorships with students and a website to spread the inspiring researchers’ trajectories from the three universities The last stage of the initiative included a one-week visit to the British institution The group was welcomed by professors Andrea Streit and Abigail Tucker coordinators of the project on the British side The Brazilian delegation was formed by professors Aline Pan (UFRGS) by technical staff Juliane Minotto (UFRGS) and Mariana Haupenthal (PUCRS) and by students Isabela Bitencourt and Natalia Dal Pizzol The students joined the mentoring program throughout the year and were selected through motivation letters The visit to King’s College London was marked by sharing good practices and networking Visitors were able to meet researchers in their areas of interest in individual conversations in addition to meetings with mentors from King’s and visits to different spaces of the British university The mission aimed to present some gender equality initiatives at KCL that can be implemented in the Brazilian context in addition to exchanging experiences and challenges for the promotion of female presence in STEM areas Group visited the laboratories of the Faculty of Dentistry the group had the opportunity to talk to Professor Jennifer Gallagher coordinator of international relations at the Faculty of Dentistry responsible for academic mobility at the faculty Diversity and Inclusion and professor Arthur Galamba the project provided an opportunity to debate important topics “The online meetings with researchers from the United Kingdom and Brazil throughout the semester and especially the partnership with King’s College helped to build new competences especially within the Brazilian institutions UFRGS and PUCRS” the visit to King’s College London was a unique experience for all of them “It made it possible for all of us to experience our areas of work and study in another country and how the British government is working with gender policies at the University I was surprised to learn that the Electrical Engineering course at KCL has 50% of its students female which is very different from the reality of 8% at UFRGS This result reflects the action and intervention of King’s institutional gender policy The British university is strongly active in the main problems and challenges of women in the STEAM area commented the professor and researcher of the Energy Management Engineering course at UFRGS Professor Andrea Streit celebrated the engagement and interaction between participants “I was very impressed to see so much enthusiasm and engagement from our Brazilian partners and participants and from the many King’s volunteers to share experiences and to find new ways of promoting women in STEM the highlight was the Brazilian team’s visit of King’s – meeting the students seeing how they made new connections and how such an exchange can open up new possibilities was wonderful They will share their experiences with their fellow students in Brazil – if we managed to make a difference Visit to the Natural History Museum in London Visit to the laboratories of researchers Abigail Tucker and Andrea Streit he event is a part of the international project funded by the British Council which brings together 7 British and Brazilian universities Included for the second time in British Council call for proposals the project now integrates 7 Brazilian and British universities Coordinator of project Women in Science at King’s College London came to University on Wednesday Free movie sessions in support of Women in Science British Council initiative to offer mentoring activities for STEM students Additional Reservation Info Get directions through Google Maps The park is about 20 miles north of Santa Cruz on Hwy 1 Año Nuevo State Park's rich variety of natural and cultural resources draws visitors from around the world The park’s Natural Preserve offers an extraordinary wilderness experience where every year up to 10,000 elephant seals return to breed and molt their skin amongst the scenic dunes and beaches The park features the Marine Education Center boasting a natural history exhibit This complex is housed in the historic nineteenth century dairy ranch of the Dickerman/Steele family These restored buildings recall the early American settlers while the midden sites throughout the Natural Preserve tell us the story of the Quiroste Indians that lived peacefully here for thousands of years prior to the 1600s Cove Beach is a short walk from here for beachgoers and surfers.The physical terrain of Año Nuevo is distinctive dune fields and coastal scrub hosting a high diversity of plants and animals including the rare and endangered San Francisco Garter Snake and California Red-legged Frog A hike out along ocean bluffs brings visitors to Año Nuevo Point a major bird migratory route and fantastic birding location.  Located just offshore sits Año Nuevo Island and the remains of a 19th century lighthouse and fog signal station.  Built in 1872 the historic keeper's house now provides a new home to Brandt’s and Pelagic Cormorants as well as California Sea Lions Otters and harbor seals are often sighted in the waters and magnificent Steller Sea Lions take up residence on the outlying rocks Click here to learn about visiting the northern elephant seals at Año Nuevo State Park Elephant seal viewing is self-guided from April to November No tours or reservations are needed to visit the elephant seals guided tours are not required to see the seals you walk out to the viewing areas on your own on the Año Point Trail there is a docent to explain what you’re seeing and answer questions. A free permit is required to visit the seals The free permit is available at the park from 8:30-3:30 Visitors will not be able to obtain a permit after 3:30 pm due to the length of time it takes to hike to the viewing areas Your visit to see the seals is a self-guided walk Click here to learn about visiting the northern elephant seals at Año Nuevo State Park Northern elephant seals come ashore during the spring and summer months to shed their outer layer of skin and fur This “molting” process takes from four to six weeks per animal as they rest along the beaches Female and juvenile seals molt from May through June and older males from July through August During the “Molting Season,” the Natural Preserve is open for self-guided hiking by Visitor Permit only Obtain your free Visitor Permit from the entrance station Visitors must exit the Natural Preserve by 5 p.m. which is earlier than the general parks closing hour of sunset Please plan to arrive early enough to obtain a permit These popular three-to-four mile hikes are considered moderate with varied terrain inlcuding sand dunes Most groups require about two and a half to three hours to make the round-trip hike The following rules and regulations are for your own safety and to protect the plants and animals that live in this park.TO SEE THE ELEPHANT SEALSElephant seal viewing requires a 3-4 mile moderate hike over varied terrain water and rain/wind/sun protection are recomended.  April - November: No tours are needed to visit the elephant seals The farthest viewing area is a 4-mile roundtrip walk from the parking lot The closest viewing area is about a 3-mile roundtrip walk from parking Which viewing areas we open all depends on the seals If they are blocking trails to a viewing area with one tall sand dune to walk over.  Visitors requiring mobility assistance are encouraged to make a reservation for an Equal Access Tour.  December - March: You must be on a Guided Walk to see the seals. Reservations are made through www.reservecalifornia.com . Reservations open October 20, for tours 55 days in advance. Visitors requiring mobility assistance are encouraged to make a reservation for an Equal Access Tour.  KEEP YOUR DISTANCE FROM SEALSElephant seals are deadly wild animals and are protected by the park Harassment and disturbance of elephant seals is prohibited by state and federal laws Seals can sometimes appear dead due to their quiet nature of sleeping on beaches the majority of the time they are very much alive Never get within 25 feet of an elephant seal pets are not allowed in the park and cannot be left inside parked vehicles in the parking lot NO BIKES ON TRAILSBikes are prohibited on all trails in the park All features of this park are protected by law NO SMOKING OR FIRESSmoking is not permitted in buildings or on guided walks NO DRONESDrone use is prohibited within Año Nuevo State Park.NO UMBRELLASNo umbrellas are allowed in the Nature Preserve area of the park (seal viewing areas) strollers are not allowed in the Nature Preserve area of the park (seal viewing areas) One of the largest mainland breeding colonies in the world for the northern elephant seal is at Año Nuevo State Park A Natural Preserve has been established to protect the elephant seals along with many other animals such as otters Native plants and an untouched intertidal ecosystem also find shelter inside the Natural Preserve Elephant seals can be observed here year round either on a docent lead tour or through a self guided permit system within the Wildlife Viewing Area Special Event Form 2024 (pdf)Special Event Guidelines (pdf) Film and Photography Permit Guidelines Senior (age 62+)   $9.00Bus (10-24 passengers) $50.00Bus (25+ passengers) $100.00Año Nuevo SP is a Day Use Park Only. There is no camping inside the park. For nearby campgrounds click here ReserveCalifornia will begin taking reservations on the following dates: PST Call toll free:  1-800-444-4445 Año Nuevo State Park1 New Years Creek RdPescadero CA 94060Phone650-879-20258:30 AM - 4:30 PM PSTNot for Reservations This park has generous support and funding from the Coastside State Parks Association and the Friends of Santa Cruz State Parks. To learn more about how these organizations help California State Parks, visit Our Partners Sign up to receive the latest State Parks news directly to your email Have a question? Use the Contact Us Page. © Copyright document.write(new Date().getFullYear());. All Rights Reserved. a transgender woman returning to a small Oaxacan town filled with trauma and secrets González says the setting for the show immediately reminded her of her own hometown: Macultepec not an easy place for a queer person to thrive But both the series and González’s story are beautiful examples of finding oneself despite obstacles The Secret of the River sensitive yet brazen boy named Manuel (played by Frida Sofía Cruz Salinas) who is forced to move in with his grandmother in Oaxaca while his mother is being treated for cancer he’s met with scorn by the macho father of his new best friend overlooked and misunderstood Indigenous Zapotec peoples recognized locally as a “third gender.” That’s when young Manuel realizes that he isn’t gay as the townspeople have been whispering behind his back; Manuel is a girl We later re-meet Manuel as grown-up Sicarù when she returns to Oaxaca for a funeral twenty years later — and reconnects with Erik they are forced to confront a shared secret from their past that Seeing the young actress Cruz Salinas portray Manuel took González back to her childhood But she is quick to clarify: “I was always very shy.” Though in childhood she might not have been as unapologetic as Manuel The now 29-year-old moved to Mexico City five years ago to pursue her dream of modeling She was quickly signed to the modeling agency Supa and moved to London for work she was having trouble finding modeling gigs but was instead presented with the script for The Secret of the River She was terrified at the prospect of acting starring in a Netflix series alongside Diego Calva she feels a lifetime away from her small hometown an hour from the Gulf of Mexico Looking back at the trajectory that led her to this moment González spoke with Them about what she learned from muxes on set and the importance of diverse storytelling This interview has been translated from Spanish to English and edited for clarity and length Xavier RevueltaDo you feel a connection between Sicarú/Manuel and yourself the actress who plays Manuel is a super cute girl she was very feminine but when I saw her dressed as Manuel But I was always very shy … What I love is her bravery in saying: “I am a woman” and treating herself like a woman That’s something I applaud and I hope many people connect with Manuel and have the opportunity to transition at the age they feel is right At the center of the series is the friendship between Erik and Manuel/Sicarú because we don’t often get stories of deep friendships between LGBTQ+ people and straight people onscreen Did you ever experience this type of relationship I didn’t have such a friendship because it was very difficult for me to hang out with boys People would tell other kids: “Don’t hang out with the gay guy don’t hang out with the faggot.” Hate is born at home are educating someone to hate something unknown it’s like what happens with Manuel and Erik and because of the ignorance of [Erik’s] father That’s what happens: You’re living and enjoying your childhood and suddenly someone comes and plants a sense of insecurity or fear in you the muxes serve as a lifeline and a peek at a life that Manuel had not thought possible Can you talk about your connection to the muxes and what they represented for you before filming the series my [knowledge] of the muxes was very limited But the information that appears in documentaries is often misleading; it’s all love and parties Something that really moved me was this need to feel heard tell what we really go through.” And that gave me this voice of bravery to bring Sicarú to life and not only tell my story but also tell their stories How do you think The Secret of the River portrays Mexico it is a story led and told by real trans women and muxes I also love that it represents a very authentic Oaxaca where the rates of femicide and transfemicide increase day by day and let’s do it as it is.” It shows many faces of machismo but also the pain that many men suffer from following this system that has corrupted us greatly Xavier RevueltaIs there anything you’ve learned about yourself through portraying Sicarú was like reliving and revisiting aspects of my childhood touching and showcasing themes that I felt had been a bit settled I am very grateful for how she embraced me One of the key themes of the series is the lack of autonomy and control experienced by children This resonates strongly with the current anti-trans legislation where larger powers dictate the identities and rights of trans youth came up when I was in the process of working with my acting teacher I believe that absolutely no one has the right to do that and I hope that no one ever has to go through it again Trans children exist and we must love them No one has the right to change someone else’s story that doesn’t belong to them Mexico is a very macho country with a lot of impunity There are things that are very frustrating there is hope and light for people to realize and become a little more empathetic about important issues The Secret of the River is now available on Netflix Get the best of what’s queer. Sign up for Them’s weekly newsletter here. Literatures and Cultures has as its main objective to offer foreign language courses to UFRN’s academic staff students and technical staff as well as proficiency exams in order to make their mobility abroad possible The Ágora Institute can also receive all foreign students and researchers from UFRN’s partner institutions in its Portuguese for Foreigners course German and Portuguese for Foreigners courses and works together with Idioms without Borders All the provision of proficiency tests in UFRN is under The Ágora Institute’s responsibility: TOEFL Literaturas y Culturas Extranjeras Modernas tiene como objetivo principal ofrecer cursos de lengua extranjera al personal académico de la UFRN así como exámenes de competencia para hacer posible su movilidad al extranjero El Instituto Ágora también puede recibir gratuitamente a todos los estudiantes e investigadores extranjeros de las instituciones asociadas de la UFRN en su curso de Portugués para Extranjeros El Instituto Ágora ofrece cursos básicos de inglés alemán y el curso de portugués para extranjeros y trabaja junto con Idiomas sin Fronteras el programa del Ministerio de Educación de Brasil para lenguas extranjeras Toda la oferta de pruebas de competencia en la UFRN está bajo la responsabilidad del Instituto Ágora: TOEFL Littératures et Cultures a comme but principal offre des cours de langues étrangères au personnel universitaire aux étudients et également aux personnels techniciens bien que des tests de compétence en langue étrangère pour rendre possible leurs processus de mobilité à l'étranger L'Institut Ágore peut aussi recevoir tous les étudients et chercheurs étrangers issus des universités partenaires pour les cours de portugais pour les étrangers ces étudiants en étant dispensés des frais d'inscription L'Institut Ágore offre des cours d'anglais d'allemand et de pourtugais pour les étrangers aux niveaux basics et travaille auprès du programme du MEC (Ministère de l'Éducation et de la Culture) Langues sans Frontières Tout initiative par rapport aux tests de compétance linguistique est de responsabilité de l'Institut Ágora: TOEFL The main goal of Tropical Medicine Institute is to consolidate The strategic goal is the education of highly qualified human resources in science and technology in the medical area and the generation of a center for the diagnosis especially in the area of the diseases neglected by centers of more advanced regions Those diseases are also prevalent in Africa and Asia El objetivo principal del Instituto de Medicina Tropical es consolidar El objetivo estratégico es la educación de recursos humanos altamente calificados en ciencia y tecnología en el área médica y la generación de un centro para el diagnóstico especialmente en el área de las enfermedades desatendidas por centros de regiones más avanzadas Esas enfermedades también son frecuentes en África y Asia Le but principal de l'Institut de Médecine Tropicale est consolider l'extension (services communitaires) la recherche et l'enseignement en Maladies Infectieuses Le but stratégique est l'éducation des ressources humaines hautement qualifiés en science et technologie dans l'aire médicale et la génération d'un centre de diagnostic spéciallement dans l'aire des maladies négligées par des centres des régions les plus avancées Ces maladies sont aussi prévalentes en Afrique et en Asie Nova Villa shared in the Tuesday episode of Mikee Quintos' "Lutong Bahay" how she got her start in showbiz saying that she was discovered by the late legendary Fernando Poe Jr The award-winning veteran actress and Goddess of Philippine Comedy was visited by Mikee Quintos and  Dang Cruz for the show's latest episode where they cooked Nova's fried tokwa with kangkong recipe Nova and Dang starred together in a series in the 90's alongside the late King of Comedy Dolphy Mikee asked Nova how she started in showbiz which turned into a trip down memory lane for the seasoned actress a comedian named Chichay from Sampaguita Pictures took her to Premiere Productions around the 1960s when she was just 17 years old adding that she got surprised when she realized it was FPJ driving a man approached her from her seat and asked her who she was with 'Iha gusto mo mag artista?' Ay dream ko 'yun Dang added that Nova did not just get any other role but the leading lady role for one of FPJ's projects In August 2023, Nova shared on "Fast Talk with Boy Abunda" that FPJ was her "favorite leading man." she received the Iconic Movie Actress of Philippine Cinema honor at the FAMAS Awards alongside Snooky Serna such as "Pepito Manaloto," "Inday Will Always Love You," and "Mulawin vs Catch "Lutong Bahay" on weekdays at 5:45 p.m {{gallery.imageDetails.images.0.description}} The Supreme Court unanimously agreed that Judge Elizabeth Scherer should be disqualified from the case of death row inmate Randy W The request came after Scherer on Nov. 2 sentenced Cruz to life in prison in the 2018 murders of 17 students and faculty members at Parkland’s Marjory Stoneman Douglas High School. Scherer could not sentence Cruz to death because a jury did not unanimously recommend the death penalty. Thursday’s Supreme Court opinion said that after issuing the life sentence to Cruz, Scherer left the bench in her judicial robe and hugged family members of victims and members of the prosecution team, including Assistant State Attorney Steven Klinger, who also was working on Tundidor’s case. Scherer turned down Tundidor’s motion for disqualification, leading the inmate’s lawyers to go to the Supreme Court. “We conclude that the combination of certain circumstances contained in the allegations in Tundidor’s motion regarding the actions of Judge Scherer in the Cruz case on November 2, 2022, and in Tundidor’s case on November 4, 2022, which he alleged showed a sympathy with the state that was linked to the outcome of another capital case, would create in a reasonably prudent person a well-founded fear of not receiving a fair and impartial proceeding,” the Supreme Court opinion said. “The crucial facts that together were sufficient to create such a well-founded fear are the hugging of ASA [Assistant State Attorney] Klinger by Judge Scherer — in the courtroom while still wearing a robe — at the conclusion of the Cruz murder case, and the personal exchange between Judge Scherer and ASA Klinger two days later, during Tundidor’s post-conviction proceedings, in which the judge commiserated with Klinger.” Tundidor was sentenced to death for breaking into the Plantation home of Joseph and Linda Morrissey in April 2010 and brutally stabbing to death Joseph Morrissey, a Nova Southeastern University professor. Tundidor and his son, Randy H. Tundidor, bound the Morrisseys by their hands and feet and set their house on fire, leaving Linda Morrissey and the couple’s son, Patrick — who was 5 years old — behind to die. Linda and Patrick Morrissey escaped and survived. Subscribe to our free News Alerts newsletter You’re all signed up!Want more of our free, weekly newsletters in your inbox? Let’s get started. Randy W. Tundidor was convicted and sentenced to death in 2012. He filed a motion in 2019 to vacate the conviction and death sentence, and Scherer was assigned to handle the case. NEWS FEED - MAKE THE DAMN FIGHT! - Spence: “Frank Martin And Pitbull Cruz Would Be A Good Fight” lightweight sensation Frank “The Ghost” Martin’s (17-0 12KO) excellent performance over top contender Michel Rivera (24-1 14KO) had the entire boxing community buzzing Unified welterweight champion Errol “The Truth” Spence Jr favors the idea of a fight with top contender Isaac “Pitbull” Cruz (24-2-1 Martin’s performance was so spectacular that boxing enthusiasts are already matching him against the top names in the division This is typical whenever a fighter gets a win of this magnitude against a fighter of Rivera’s caliber When asked who he wants next, Martin initially stated he wanted all the top guys during the post-fight interview, before mentioning the names of Gervonta Davis, Rolando Romero, and Haney Martin fights under the banner of Spence Jr’s promotional company, Man Down Promotions. During an interview with ESNEWS The Truth put on his promoter’s hat and seemed to favor a fight with Cruz more that’s going to make Frank let his hands go a lot more He actually does better with people that are engaging him.” Team Cruz may pass on the offer considering a title shot is within their grasp They recently turned down a fight with two-divisional champion Shakur Stevenson It is unlikely they are willing to take the same risk Rivera did with so much at stake Ring Roll Call: Former Featherweight Contender Abraham Nova Lopez Declines Warrington Rematch: “Never; He Is A Dirty Fighter” Middleweight contender unleashes on Instagram Well, well if things didn’t all of […] Anthony Joshua breaks down future opponents Unified Heavyweight Champion Anthony “AJ” […] Joshua gets brutally honest on loss to Ruiz They say time […] the disease caused by the novel coronavirus has killed over 2 million people around the world C&EN asked the chemistry community to share memories of colleagues or loved ones in the field who died of the disease If you would like to honor a chemist who died of COVID-19 and he was one of the finest chemists produced by our chemistry alma [mater].”—Sridhar Ydhyam University of Puerto Rico Río Piedras Campus Puerto Rico “She was an extraordinary educator and published important papers in the ‘ Journal of Chemical Education’ and in ‘ Chemical Educator .’ When we both taught general chemistry in ACS’s Basic Package keeps you connected with C&EN and ACS $80 Regular Members & Society Affiliates ACS’s Standard Package lets you stay up to date with C&EN ACS’s Premium Package gives you full access to C&EN and everything the ACS Community has to offer COVID-19 Science's greatest test Will public trust in science survive the pandemic? How COVID-19 has changed the culture of science 8 tools that helped us tackle the coronavirus Is drug repurposing worth the effort? A year in the COVID-19 pandemic Remembering the chemists we lost to COVID-19 COVID-19, the disease caused by the novel coronavirus, has killed over 2 million people around the world. C&EN asked the chemistry community to share memories of colleagues, friends, or loved ones in the field who died of the disease. Here is what they said. If you would like to honor a chemist who died of COVID-19, please visit bit.ly/chemistslosttocovid “She was an extraordinary educator and published important papers in the ‘Journal of Chemical Education’ and in ‘Chemical Educator.’ When we both taught general chemistry in a coordinated course I learned how great she was as a colleague She contributed immensely to the development of chemistry in Puerto Rico retired chair of the Department of Chemistry and Biochemistry “Lea was my best friend and like a sister to me We always studied together and were never separated through our BSc and MSc at Technion and then PhD at the Weizmann Institute of Science and then she became a professor in New York and I in Chicago We collaborated on some educational projects She was very passionate about her students She participated in many American Chemical Society meetings and joined the ACS delegation to Cuba in 2004 Research Institute for Scientists Emeriti program “Professor Demain had a wicked sense of humor and would constantly crack jokes in our interactions he was also incredibly down to earth and happy to chat even going so far as getting a USB floppy drive for his laptop.”—Nicholas Chiappini I shared lab dependencies with him almost 4 years during my undergraduate course in pharmacy It was really a shame that we lost someone to this disease so suddenly ‘Saudades’ is the word in Portuguese which best describes the feeling now National Center for Atmospheric Research (NCAR) Hans Friedli had a 33-year career at Dow Chemical He worked in product and process R&D and management achieving the rank of research scientist and earning 43 patents He had a wide range of technical expertise—polyurethane technology monomers—and contributed to global R&D strategic development Hans embarked on a 15-year second career at NCAR working in aerosol chemistry He was a leader and active participant in scientific and humanitarian causes in his local communities.”—Andrienne Friedli “Writing papers with him was one of the most important lessons I learned in my scientific career As a scientist he was not only smart and original but also persistent with a very positive obsession for details he was an extremely kind person with a strong sense for the beautiful things in life and we all lost a good friend.”—Wolfgang Maison “My father enjoyed chemistry his whole life He liked to tell the story that in one of his first jobs in Taiwan in the early 1950s he developed a technique to seed the clouds to make rain in Taiwan by adding silver iodide to coal delivered by locomotive.”—Grace Lee my dad would quiz us kids on principles of chemistry at the dinner table or the same time for rice to cook at sea level compared to on a mountaintop And why do you think there should be a difference?’ All of us kids would groan can we have a normal conversation?’ He did get his way because although none of his three children ended up as chemists we all eventually got at least a little of his scientific inquiry bug My older brother became a geology professor and my little sister became a psychological scientist.”—Annette Lee “Gheorghe brought terrific energy and enthusiasm to the Chemistry Department at Case Western Reserve University throughout his distinguished career working with Nobel Prize winner George Olah or running his latest nuclear magnetic resonance spectroscopic experiments always left you with a smile He cared deeply for all members of the department for whom he generously endowed several awards Gheorghe's strengths in bringing people together from many countries made him remarkably successful in organizing collaborations He was also a constant reminder of how immigrants have enriched the US and strengthened our international scientific position.”—John D As a chemist he was very enthusiastic about Amazonian natural products We will always remember Alberto as the best friend for colleagues and students.”—Diana Cristina Sinuco Peters taught my analytical chemistry course while I was an undergrad he made every effort to interact with the students in his course We went to get coffee and he’d tell me of his time doing research as a student (in the ’50s!) and the excitement he had 50 years later was still palpable He really contributed to my desire to go to grad school and he is profoundly missed.”—Jeremiah Gassensmith “Ronei was one of the kindest professors I had in the last couple of years He always listened to the students and sought to help them the best way he could He would break down chemometrics with passion but in a lighthearted and interesting manner spreading his love for chemistry to everyone who attended his classes.” —Gabriel Zamboni Bill worked for 4 years in the pulp and paper industry as a bleach chemist (at Union Camp and International Paper) Bill moved to Pacific Northwest National Laboratory (PNNL) in the materials science department where he rose to the rank of senior research scientist Bill was a polymer chemist who worked in thin-film optical materials Bill retired from PNNL in December of 2012 he went on to a series of short-term teaching appointments retiring to eastern Washington in 2017.”—Glen E choosing a research mentor is the most important decision a scientist can make I was very fortunate that I chose professor Dietmar Seyferth as my PhD mentor I kept in touch with him over the years since receiving my PhD So it was with great shock and sadness that I learned of his passing in June of 2020 from COVID-19 He provided me with not only the research foundation that I needed for a brief career in industry (10 years) but also the organizational and other communication skills for my career in academia (33 years and counting) I was honored to have been able to write not only about what he meant to me as a research adviser but what he meant to multiple generations of his students.”—Joseph S head of the Laboratory of Metal Complex Activation of Small Molecules Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences (INEOS RAS) having worked at INEOS for almost 60 years His research interests were related to the fixation of molecular nitrogen acetylene and zwitterionic complexes of group 4 metallocenes and coordination and catalytic chemistry of anticrowns He was a unique polymath in various fields and a man who was truly loved and respected.”—Vladimir V as his family called him) was a very quiet and gentle man He kept to himself but was always ready to share stories of his past with anyone that would listen He preferred to walk than to drive his car He was a member of Saint Joseph Catholic Church in Jasper and a 56-year member of the American Chemical Society He was an avid fan of Indiana University football and basketball and the stock market He was also proud of the fact that he never bought a lottery ticket.”—Rose Terwiske and inspiration to many chemists in New Jersey and nationwide As a career consultant and leader in the ACS North Jersey Section he took every opportunity to promote and support the chemistry profession I am so happy to have spent time getting to know him well and to learn from him Bill will be missed by many at ACS!”—Rick Yglesias “Professor Frank Tsung was a rising star in our community and materials science to add function to nanomaterials He would start with controlling nanoscale structure and goals and then would bring together materials to go all the way to function in catalysis and other areas We were always excited to see and to hear what he was doing and planning What a terrible loss for our community.”—Paul Weiss “He inspired me by demanding that I become the best I could be He gave me the confidence to go on to get a PhD in organic chemistry I have had a wonderful life and wonderful career I am grateful to professor Viola for his kindness and inspiration.”—Ann Beaulieu “He worked tirelessly to advance theories and ideas and he even had a cot in his office as a landing place for long nights of work His love of chemical engineering involved him in many collaborations and studies with colleagues from around the world Mike was known for being a meticulous and detailed researcher and had a playful side that led to him authoring a gossipy newsletter at the University of California that was read by all (but admitted by none).”—Family of Michael C This article has been sent to the following recipient: Sign up for C&EN's must-read weekly newsletter Copyright © 2025 American Chemical Society Acadian Village was one of my favorite stops during our Nova Scotian whirlwind weekend. It's located on a beautiful 17 acre site that overlooks the Pubnico Harbour, according to their website Being there felt like I had taken a time machine back to the early 1900s The workers were dressed in the traditional garb of that era and the furniture and decorations were perfect little village as it once was in the 1900s I also sampled their famous molasses cookies that were baked in an old-fashioned oven Acadian Village was one of my favorite stops during our Nova Scotian whirlwind weekend.\nRead More Acadian Village was one of my favorite stops during our Nova Scotian whirlwind weekend. It's located on a beautiful 17 acre site that overlooks the Pubnico Harbour, according to their website You are using an outdated browser. Please upgrade your browser or activate Google Chrome Frame to improve your experience Remote power generation specialist Zenith Energy will build upon its renewable energy options at Western Australian miner IGO’s Nova nickel site to demonstrate it is possible to use 100% renewables to meet the demands of an operational mine site A 6.7 MW solar farm is already in place at the Nova mine site Perth-based Zenith Energy has announced it will install additional solar PV and battery storage capacity at IGO’s Nova nickel-copper-cobalt operation in West Australia’s Goldfield region allowing the mine to be powered continuously by on-site renewables for up to nine hours at a time The Nova site, in the Fraser Range about 360 kilometres southeast of Kalgoorlie, is currently powered by a 26 MW hybrid solar PV-diesel plant The addition of another 10 MW of solar capacity and the installation of a 10 MWh battery energy storage system is expected to allow for 100% renewable power generation during daylight hours which owns and operates the existing hybrid power plant said the deployment of additional solar generation and energy storage will be key to achieving ‘engine off’ storing sufficient power to ensure supply and reliability of the system is not compromised said the project will require the integration of “specific technology into the power system to provide inertia and stability “While there are currently non-industrial micro-grids operating on 100% renewables the Nova project will prove it’s possible to use 100% renewables to meet the demands of an operational mine site,” he said “It will also prove the ability for sites to go ‘engine off’ for consecutive hours Da Cruz said the Nova project will also demonstrate that 100% renewable energy penetration can be sustainably achieved and replicated on other sites across Australia now without having to wait for further advancements in technology “This project sends a strong message to the industry that powering an entire site completely on renewables is possible today,” he said “For sites where renewables are already part of the power generation system increasing renewable assets to go ‘engine off’ is a natural next step on the pathway to net zero.” Fellow Western Australian energy company Hybrid Systems Australia (HSA) has already demonstrated that powering an industrial site with 100% renewables during daylight hours is achievable In late 2020 HSA installed a 1.2 MW solar farm, a 2 MW diesel power station and a 350 kWh lithium-ion battery at environmental services company Tellus’s  Sandy Ridge mine and waste facility near Kalgoorlie The system was switched on in December 2020 and the facility is being 100% powered by renewable energy during daytime operations thanks to a 15-year power purchase agreement (PPA) Da Cruz said while Nova will continue to rely on diesel-generated power overnight and during inclement weather conditions he is confident the industry is approaching a tipping point where 100% renewable power generation will be possible 24 hours a day “Zenith is already looking at what subsequent steps are needed to achieve this ultimate goal including how we facilitate higher levels of renewable penetration and integration of long-duration storage,” he said “It’s an exciting time not just for Zenith as a company We’re making real progress in the decarbonization space and what that might look like for the sector moving forward.” IGO chief operating officer Matt Dusci said the project is an important next step in the miner’s journey towards carbon neutrality and sets a new “benchmark” for the resources industry “We are now at a point where technology and cost structure are enabling powering of an entire mining operation with 100% renewable penetration,” he said “By supporting greater uses of renewable energy at our Nova operation it will set a new industry benchmark in renewable energy integration and demonstrates our commitment to decarbonise our business.” The existing Nova solar farm has been operational since 2019 and last year provided more than 11% of the mining operation’s total power consumption displacing about 2,444 kilolitres of diesel and eliminating 6,600 tonnes of carbon the solar panels and battery energy storage system are set to be relocated to another site in what will be “the first practical demonstration at scale of relocatable renewable energy” “Proving this will assist in reducing barriers to capital expenditure as renewable assets are used in multiple locations over their life span,” Zenith said in a statement “It will also fast-track deployment of solar and further emission reductions across Zenith’s legacy portfolio.” The announcement comes after IGO signed an agreement with Perth-based energy storage company VSUN Energy to trial a hybrid standalone power system (SPS) backed by a vanadium redox flow battery (VRFB) at the Nova site a subsidiary of Australian Vanadium Limited (AVL) will install a SPS based on a 300 kWh VRFB supplied by Spanish battery manufacturer E22 which will be used to power a bore pump on-site has been designed to provide a 100% renewable energy supply for much of the year although the initial 12-month trial will target a total renewable penetration of 85-90% More articles from David Carroll Please be mindful of our community standards and website in this browser for the next time I comment Δdocument.getElementById( "ak_js_1" ).setAttribute( "value" By submitting this form you agree to pv magazine using your data for the purposes of publishing your comment Your personal data will only be disclosed or otherwise transmitted to third parties for the purposes of spam filtering or if this is necessary for technical maintenance of the website Any other transfer to third parties will not take place unless this is justified on the basis of applicable data protection regulations or if pv magazine is legally obliged to do so You may revoke this consent at any time with effect for the future in which 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To find out more, please see our Data Protection Policy. × The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this Close IGO has continued its partnership with Zenith Energy to prove it is possible to use 100 per cent renewables to meet the demands of an operational mine site owner and operator of the power station at IGO’s Nova nickel-copper-cobalt operation in the Goldfields region of Western Australia and will expand its renewable generation to successfully operate ‘engine off’ for up to nine consecutive hours a day The site is currently powered by a hybrid solar and diesel engine system and will expand its renewable energy capabilities through the addition of an extra 10MW of solar panels The storage system is a key component of achieving ‘engine off’ IGO chief operating officer Matt Dusci said the renewable power generation is an important next step in the company’s journey towards carbon neutrality “By supporting greater uses of renewable energy at our Nova operation it will set a new industry benchmark in renewable energy integration and demonstrates our commitment to decarbonise our business,” Dusci said “As a company we continue to challenge ourselves on continuous improvement We are now at a point where technology and cost structure are enabling powering of an entire mining operation with 100 per cent renewable penetration.” Zenith executive manager – growth Dominic Da Cruz said his company is taking on the responsibility of not only developing the concepts to advance renewable solutions but also piloting and proving the integration of technologies needed “The Nova 2.0 project will require us to integrate specific technology into the power system to provide inertia and stability Da Cruz said the project would boost renewable penetration on site to allow for 100 per cent renewable power generation during daylight hours Based upon a power purchase agreement struck up with IGO in October 2018 Zenith built its facility to complement the previous Nova diesel power station he is confident the industry is approaching a tipping point where 100 per cent renewable power generation will be possible 24 hours a day “Zenith is already looking at what subsequent steps are needed to achieve this including how we make wind assets relocatable to achieve higher levels of renewable penetration and the integration of long duration storage,” he said We’re making real progress in the decarbonisation space and what that might look like for the sector moving forward.” Australian Mining has informed the industry on the latest news and technologies from across the mining sector Australian Mining is a leading resource showcasing the latest in mining innovation Look out for your first newsletter in your inbox soon We help you navigate a myriad of possibilities Sign up for our newsletter for the best of the city By entering your email address you agree to our Terms of Use and Privacy Policy and consent to receive emails from Time Out about news Sign up for our email to enjoy your city without spending a thing (as well as some options when you’re feeling flush) Our newsletter hand-delivers the best bits to your inbox Sign up to unlock our digital magazines and also receive the latest news By entering your email address you agree to our Terms of Use and Privacy Policy and consent to receive emails from Time Out about news, events, offers and partner promotions. Porto At the restaurant in the Espaço Porto Cruz order lots of snacks and try out each of them including octopus fillets with tartar sauce or cod “iscas” there's a different menu with DOP “maronesa” beef ribs with oven-roasted rice or the fresh cod and mussels “cataplana” pan with grapes and saffron You can also order the special menu for two and try the roast veal cheeks with creamy sausage rice or the butter bean clams Thanks for subscribing! Look out for your first newsletter in your inbox soon! instagramAbout us Contact us