Mission accomplished for Rubierese who beat (3-1) the Original Celtic Boys, taking 4th place from the Madonnina thanks to a better overall goal difference that is worth the derby on the FalkGalileo pitch. For the red and whites, a double by captain Vanacore (penalty and personal action), then the seal by the midfielder Iossa, while for the green and whites, Keita scored.
Pointless return from 0-2 to 3-2 for the guastalla on Solierese: the play-off objective fades by one point after the rossoblù had always achieved it in the last two seasons. The striker Allai scored, able to exploit a rebound, then a low shot by Truzzi freed by Mezzani, finally Bigi resolved a melee.
Tagliavini's shoot seals the draw for the Campeginese on the synthetic pitch of the Madonnina and the consequent visa for the play-out in a single match at home against the other newcomer Corlo, a corsair (4-1) over a demotivated Boca Barco.
Bitter double somersault for theAtletic Mountain Project which falls (5-4) on the Virtus Correggio field, but even a blitz would not have saved the Bismantovini.
A goal by Arioli seals the 1-1 draw Saint Prospero Correggio in S.Ilario, essential for the final play-off pass against the winner of Virtus Mandrio-Rapid Viadana. The yellow-greens regulate (3-1) Saxum United thanks to the strength of the long bench from which the match-winners Melis and D'Elia rise; previously a tit for tat between Arletti and Zoina.
Fundamental blitz of the Puianello which guarantees the double play-out with Boiardo Maer: after the unfortunate own goal scored by Di Iorio, the doubles scorer Kokolari takes care of it with two conclusions from outside to overturn the match, interspersed with a header from Albertini.
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entrepreneurs with a forward-looking and out-of-the-box vision
in just four years have created an important business and landmark in a region that is not as simple as Liguria
putting together an entrepreneurial idea of integrating agricultural
hospitality and catering activities that is embodied in a name: PEQ Agri
as we have already had the opportunity to tell
it translates into 200 hectares of land (destined to grow)
an artisanal laboratory for processing products and three restaurants
The one we want to focus on today is the wine reality because it represents a virtuous example of the valorization of an indigenous viticulture that covers practically every type of oenological product
after acquiring important historical brands and integrating them into Cantina Lupi
but above all having restored and given new life to land once cultivated with vines but later abandoned and left to neglect
the company seems to have clear ideas and is implementing a real revolution in the Ligurian wine sector
The Lupi Winery of PEQ Agri therefore cultivates and produces today all the main doc wines of western Liguria
Cantina Lupi takes care of its entire winemaking chain
producing wine at its two historic wineries in Colla Micheri
The land allocated to vineyards is divided into just over ten plots
Given the very strong biodiversity that characterizes the area
different soil compositions (even a short distance apart)
Marco and Giorgio immediately made the peculiar decision to vinify each vineyard separately
to represent in its entire plurality and diversity the extraordinary oenological power of the territory and to tell its story through wine
A very interesting example of this unique strategy is Pigato
certainly the most representative AOC of Ponente Ligure
which Cantina Lupi vinifies with no less than five labels that represent and testify to the unique characteristics of the vineyards of Balestrino (Pigato Campulou)
where the vines are located at an altitude of 500 meters and on a volcanic vein (Pigato Canneto)
Pigato Petraie and the renowned Vignamare)
are in fact characterized by peculiarities and diversity that result in three labels
The Vignamare vineyard fully illustrates this choice: it is located on red clay soil
is the result of the collaboration between the founder of the winery of the same name
who together developed this precious and highly successful product
This is evidenced by the fact that in the restaurant of the same name
which still reveals a remarkable freshness when tasted
are only one of many examples of a clear business strategy and its results
one Lumassina and one Granaccia are all expressions and narratives in the glass of the immense effort to enhance and tell the story of its territory
although strongly anchored in the traditions and influences of its wine-making history
has nonetheless embarked on a path marked by research and the development of new references
One example of this is the sparkling wine project with an ambitious idea: to vinify Rossese grapes in white and create a blanc de noir that would best represent this ancient Ligurian grape variety
The result is an excellent bubbly pas dosé that boasts 31 months of aging
flanked by a Martinotti method (woe betide calling it Charmat
Winemaking decisions are coordinated with the young Alex Berriolo
a professional already active at Casa Lupi
who provides the needed continuity guarantee with history
best represented in its expressions: ruby red when vinified in red and coral pink when vinified in white (sciac-trà)
Its vineyards are located at 550 meters above sea level in the most vocated area and come from the ancient estates of the Scarella Marquisate in Pornassio
an Italian-style rosé vinified with the bloodletting born by inland farmers
Berry&Berry is the result of the innovative ideas of winemaker Alex Berriolo
who in 2010 began making wine from grapes from the land his family has been cultivating for three generations now
this winery produces five sui generis labels
so much so that they do not fall under any appellation and are in fact true (successful) oenological experiments that are the result of blending and winemaking taken to the limit and beyond
a winemaker in Balestrino and an early 20th-century ancestor
from white from Pigato and Vermentino in varying percentages depending on the vintage
from the vineyards of Albenga and Tovo San Giacomo
with a very pleasant salty background note
Website
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The journey of the Canossa Magpies, defeated 79-68 in front of their home crowd by Ducal Magik Parma despite the 37 points of an indomitable Benvenuti, who tries everything to keep his team in the race.
The season also ends for Saint Hilary: in Fidenza, in fact, they are the Struck by lightning to take home game 3 with a score of 83-64, making the efforts of Catellani (17), Pergetti (11) and Parente useless.
DR1. The 78-46 away success on the Villanova Tigers' field (0) is not enough for the Basketball Jolly (6) to continue to cultivate hopes of coming second in the Poule Promotion of Regional Division 1. The simultaneous victory of Massa Lombarda over Mo.Ba Modena, in fact, sends the Ravenna team to +4 on the city quintet with only one day to play.
Archive Projects
Composer Anna Clyne and the violin with a lion-head scroll that she discovered
In Monday’s (8/19) Strad (U.K.)
composer Anna Clyne was in an Oxfam charity shop in Oxford … when she noticed a dusty violin case … She opened up the case to discover a violin inside
and it looked a little beaten up,’ she recalls
What was remarkable to her was the violin’s scroll
which portrays a lion’s head with its tongue sticking out
Clyne was quick to snap up this bargain and took the violin to Bruno Guastalla
Gustalla informed Clyne that it would cost £100-200 to repair … Later
Clyne received a message from Guastalla on social media
saying he had heard her music and offered to exchange repair of the violin for composition lessons… The next time Clyne was in the UK
she dropped off the violin for repair with Guastalla
and the two embarked on a knowledge exchange of composition lessons…
reached out to violinist Cornelius Dufallo
for another exchange: this time violin lessons in exchange for a new violin work
written by Clyne for Dufallo and his violinist wife
The work then expanded into a suite of seven pieces called The Violin.”
, the award-winning publication of the League of American Orchestras, discusses issues critical to the orchestra community and communicates to the American public the value and importance of orchestras and the music they perform.
Text description provided by the architects. MCA project won the Architectural Competition held in February 2014 for the design and build of the new School in Guastalla District (Reggio Emilia, Italy). The new building will replace two existed schools damaged by the earthquake which stuck the territory in May 2012 and will host up to 120 boys and girls between 0 and 3 years old.
MCA project is thought to stimulate the child's interaction with the surrounding space according to a vision of "teaching" in which nothing is left to chance, from the distribution of educational areas to the choice of materials of construction, up to the integration between indoor and outside space.
© Moreno MaggiThe structure involves the use of natural materials with low environmental impact. In particular, the supporting structure is made up of wooden frame: a safe and ideal material to keep the thermal insulation of the building.
© Moreno MaggiThe high insulation, the optimal distribution of transparent surfaces, the use of advanced systems for rainwater harvesting and insertion of a photovoltaic system on the roof, will allow the building to minimize the use of mechanical equipment to meet the energy needs of the school. So children are driven to discover places that are complex and at the same time familiar, where they can develop abilities through special features of each.
© Moreno MaggiEven areas of connection between the classrooms and laboratories are designed to be lived with curiosity and pleasure: along the route there are widening, play and relationship areas, niches where you can stop, transparent elements to watch out or peek activities the other children.
it also articulated the sensory journey outside the building
which integrates the existing trees and encompasses the structure creating protected areas for the activities of the children
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in Western Liguria on the hills between Laigueglia and Andora along the Via Julia Augusta
was the wonderful retreat of the great ethnographer Thor Heyerdahl
where you can stay in one of the cozy apartments of Casa la Meridiana
the road to one of the key points of the agricultural
and hospitality universe of PEQ Agri is short
and you find yourself in front of a breathtaking sea view surrounded by a lush amphitheater of vineyards among the woods
The area in question includes Terrazza Praié
with its casual culinary offerings and summer brunch featuring local products
the Vignamare restaurant housed inside an old cistern
a green and red Michelin star with the remarkable cuisine of the talented Giorgio Servetto
It's not easy to describe what he has achieved with his cousin Giorgio Guastalla
thanks to a personal revolution that saw them settling in Liguria after literally traveling the world as managers and entrepreneurs
Our great-grandfather had the foresight to choose Andora as the preferred location for family gatherings as early as the twenties
We all have a special relationship with this place
cemented by sweet and poignant memories. It's here that all our relatives come together
I meet Giorgio and we start talking about this idea and discover that we share the same desire
and physical and mental well-being at the center
We were aware that it wouldn't be an easy journey
the opportunity arises that convinces us definitively to embark on this fascinating and emotional journey: the only wine producer in Andora tells us that he is in negotiations to sell his vineyards to foreign entrepreneurs who want to build a resort
We don't think twice and decide to acquire the vineyard and cellar and start shaping the PEQ Agri project
we leave our jobs and our cities behind and move to Andora
We almost immediately bought an acre of countryside and started producing our vegetables following the rhythm of the seasons and the knowledge of tradition
the drive to open a restaurant to share the fruits of the land with customers who shared our worldview
a lab for the processing of surplus products
and today we have 70 employees and 200 hectares of land including vineyards
Quality': spending some time with the two founders makes it clear that this is not just a simple and empty slogan
but rather energy and love for the mission they have set for themselves
with the idea of micro-enterprises federated in a virtuous system
It is understood from the fact that the classic paradigm is overturned: it is no longer agriculture that humbly and poorly serves industry and distribution
plays a central role and dictates timing and methods to all activities functional to its valorization
Marco continues: "Both Giorgio and I have worked in the food industry in the past and we realized how distant the end consumer was from agricultural reality
That's why we want to convey to our guests and customers a basic concept: those who choose to purchase our products or taste them at our restaurants are aware of making a very important contribution to the realization of a virtuous project and mechanism for the community."
an expression like 'promoting the territory'
with the idea of modernizing the traditional farm
using its products and transforming them when in excess to waste nothing and optimize
an innovative development model of an 'extended' agricultural company that involves investments in renewable energies
the recovery of abandoned agricultural land (most of the cultivated land comes from the recovery of uncultivated and abandoned areas to degradation)
and work tools that allow supporting more than fifty families
giving young people the opportunity to not leave the Ligurian Riviera and have a dignified
A reclamation path involves the restoration of ancient
characteristic stone walls and the regulation of water in the Andora valley
derive from acquisitions of three qualitatively important and well-distinct brands (Lupi
Each of them owns historic vineyards and native grape varieties such as Pigato
is the result of collaboration with the in-house winemaker and his family vineyards
It goes without saying that the company and its restaurants source their needs from their own supply chain
in addition to bees that produce exquisite honey; there is also excellent extra virgin olive oil from over 15 hectares of olive groves
Everything can be purchased in the retail outlets
as well as enjoyed at Terrazza Praié and Vignamare and at the Agriturismo PEQ Agri Resort in Tovo San Giacomo
the company has also created a line of cosmetics based on agricultural products: extra virgin olive oil
and lavender are indeed the main ingredients of fragrant body soaps
The nature of PEQ Agri is extremely dynamic
and Luzzati and Guastalla have several interesting new projects in the pipeline
But we'll have the opportunity to talk about it again..
Website
the exhibition Luigi Ghirri: Pollicino’s Stones
curated by the GhirriArchive and Culture Councillor Gloria Negri with the scientific advice of Franco Farinelli.Visible until November 30
the exhibition created on the80th anniversary of the birth of Luigi Ghirri
one of the major protagonists of the photographic and visual culture of the second half of the 20th century
presents eighty color photographs belonging to the Vintage repertoire (printed with Luigi’s direct approval and control)
the Modern (printed posthumously but with the control of his wife Paola) and current prints (made by the same workshop that has always been involved in Ghirri’s work and controlled by the Archive)
Photographs representing places and spaces of the Po Valley territory
The first section displays images of Guastalla
Pomponesco and other localities of the Bassa
followed by photos of the countryside of Reggio Emilia
Bologna and Mantua and the banks of the Po River
The third section offers a discussion of the relationship between interior and exterior as a “reminder of a certain way of life
culturally highly connoted.” As Luigi Ghirri put it
cinemas and stores look like miniature museums full of objects
a sort of local album.” The exhibition concludes with an image of Paola
according to the reading of Franco Farinelli
lies in that intermediate area between the concepts of place and space that Ghirri manages so well to penetrate
precisely connoted place known to our everyday life and the horizons toward the infinite of our plain lies our human experience that possesses both
For info: ufficiocultura@comune.guastalla.re.it - 0522 839761/756
Saturday and Sunday from 9:30 am to 12:30 pm and 3:30 pm to 6:30 pm
Workshops and ateliers for schools will be organized in October and November
Giorgio Guastalla set up Keywords in Dublin in 1998 with his wife, Teresa Luppino, and now runs an Italian food import business. He is still a director of Keywords and owns 90% of PEQ Holdings, which remains the largest shareholder in Keywords, with a 6.3% stake.
The stake is worth £58.1m (€67m) following a surge in the outfit’s share price, after it reported strong results for 2018 last week. The shares closed at £14.53 in London on Friday, up from a low of £8.85 in February. Keywords is valued at £930.5m.
Company filings show PEQ sold shares worth about
Registered in England No. 894646. Registered office: 1 London Bridge Street, SE1 9GF.
1971Following37Follow3737 FollowersLorenzo Puglisi is an author of a pictorial research characterized by the widespread use of black colour on the canvas which creates an absolute dark background
where the emanating streams of light are able to define volumes
there was a need for a new nursery school to replace two schools that were badly damaged in the earthquake that shook the region in May 2012
The winner of the public bidding process initiated by the municipal administration was the Mario Cucinella Architects studio of Bologna
which came up with a single-level structure based on the multiplying effect of 50 laminated wood portals interspersed with large windows
Making something for children doesn’t just mean making it small but also
The new public nursery school occupies 1,400 square metres of space and was conceived as a place to educate children starting from infancy not just about play and creativity
born from the successful joining of force of architecture
opens up like a fairy book landscape meant for exploration and discovery
perfectly in sync with the surrounding environment and made exclusively of natural or recycled materials with low environmental impact
through which you pass to access a space that welcomes children like a warm hug
illuminated by big windows (that reduce electricity use) and full of sensorial stimuli (provided by shapes
ready to offer children many different inputs to let their imaginations soar
The same philosophy was applied to the outside where a sensory garden was created
a forest full of bushes and aromatic plants that are watered by a rainwater collection system
In keeping with a philosophy that is always (and also) thinking about ways to save
winner of the competition to replace the two public nursery schools that were damaged in the 2012 earthquake
in fact cost less than €1,650 per square metre
Capable of welcoming as many as 120 children between the ages of 0 and 3 years old
“On that day it was wonderful to get to explain to the children how the nursery that they attend works
and to explain why we made the environmental choices that we did
It is a project that now even the little ones are a part of”
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Italy has more cultural and historical treasures than any other country..
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Before coming to the Met, Galilee, an architectural historian, was chief curator of the 2013 Lisbon Architecture Triennale and co-curator of citywide architecture festivals in Gwangju, South Korea, and Shenzen, China, and director of The Gopher Hole, an exhibition and project space in London.
While recovering from the whirlwind event at the Met, she sat down with Fred Bernstein of AD to revisit it.
Architectural Digest: Why bring all these architects together on one day?
Beatrice Galilee: When you see one architect after another showing work that was built in the same year, it has a real impact. Seeing one lecture every few months would not have had the same effect.
The National Museum of African American History and Culture in Washington, DC.
AD: You asked people to come from very far away.
BG: It’s important to look at architecture globally. Also, it’s a way to represent the diversity of cultures and identities reflected in the profession. Architecture is not just the realm of the rich and famous.
But most importantly, if people come from all over the world to present their work, you see connections and parallels that you wouldn’t have discovered otherwise.
BG: A lot of the architects who spoke aren’t looking to create spectacles. They’re interested in responding to specific places, to forming relationships with particular landscapes.
AD: That was certainly true of Wang Shu. He flew halfway around the world, only to introduce himself as “a very local architect.” And he showed a project, the Fuyang Cultural Complex, that almost disappears into the landscape.
BG: That building is not happening anywhere else in the world. It’s about those bricks made with those hands; its meaning is tied to that location.
AD: He said his work was inspired by the gossamer quality of Chinese landscape paintings, including some that are at the Met.
BG: It was nice that it had that connection.
Heneghan Peng Architects' Palestinian Museum on the West Bank.
AD: Shih-Fu Peng of Heneghan Peng Architects, in Dublin, showed the Palestinian Museum on the West Bank. He talked about the way it follows the abandoned agricultural terraces, taking the land from food production to cultural production.
BG: And Junya Ishigami, of Tokyo, showed a glass pavilion in a park in Holland that follows the lines of existing pathways. In some of the photos you couldn’t see the pavilion at all. I thought it was exquisite.
AD: I remember Wang Shu asking, “How can you make a huge, 400,000-square-foot building disappear in the landscape? Peng said, ”What’s best about the museum is that it almost disappears.” And Ishigami spoke about “the possibility of creating architecture as new landscape.”
BG: There’s a lot of concern about the impact on the planet. It’s not complete coincidence — I chose the architects on the program and I share that concern. In my view, architecture can’t be presented in a political, social, or environmental vacuum.
AD: Ishigami wasn’t the only Japanese architect to win over the audience.
BG: Right. Go Hasegawa showed a marble chapel in Italy, which he just completed. It was beautiful and precious and special, and I heard some people say it was the high point of the day.
AD: Marwa al-Sabouni, who works in Homs, Syria, couldn’t get a visa to attend.
BG: Marwa never expected to be able to travel to New York, so instead of paying for her flights and accommodations we gave her a budget to make a film. She showed the devastation in Homs, and her ideas, as an architect, for rebuilding that city from the rubble.
AD: Some of the buildings were more familiar. The Columbia Medical School building that Elizabeth Diller presented [the Vagelos Center] and the National Museum of African American History and Culture, which was shown by David Adjaye, have been widely published. That was also true of the new courtyard at the Victoria and Albert Museum in London, presented by Amanda Levete.
BG: To certain people they may have seemed familiar. But we had many audiences, including people with only a passing knowledge of architecture.
The Victoria and Albert Museum's cutting-edge expansion in London.
AD: Now that the event is over, what are you working on?
BG: There’s a lot of architecture at the Met — the period rooms, the Temple of Dendur, drawings by Vitruvius and Piranesi, photographs, films — it’s a history of architecture, but it has never been seen as an architecture collection. I’m trying to create a framework for understanding architectural history through the Met’s collection. It could become a book or an exhibition or an app — it’s too early to know.
AD: Will there be “A Year in a Day” in 2018?
Connecting decision makers to a dynamic network of information
Bloomberg quickly and accurately delivers business and financial information
a maker of high-end kitchen appliances in the northern Italian town of Guastalla
he has watched as the financial meltdown and euro crisis battered his key markets
Yet even as appliance sales in Europe’s biggest countries stagnate
expecting revenue growth to top 18 percent this year
after jumping 23 percent in the first quarter
“There is a significant group of customers whose aspirations and lifestyle give a central role to cooking for the family
Our products are made to respond to this desire with style.”
The 130-year-old company has managed to keep growing in large part by looking to new markets
Bertazzoni has redesigned some products to suit American tastes
including super-sizing ovens so they can accommodate massive Thanksgiving turkeys
sales there have grown to about a fifth of the company’s revenues
“We have developed a product that is suitable for the American market
yet with a strong Italian identity,” Bertazzoni says
by Elisa Mazzini /// March 14
The warm season in Emilia-Romagna is marked by numerous initiatives dedicated to greenery
On Saturday 22nd and Sunday 23rd March 2025
the historic centre of Rimini will host the spring edition of Giardini d’Autore
the botanical event dedicated to plants and gardens
between Castel Sismondo and Piazza Malatesta
On Saturday 29 and Sunday 30 March 2025, the city of Piacenza will celebrate the arrival of spring with Piacenza in Fiore
On Saturday the 5th and Sunday the 6th of April 2025, the traditional spring date with Carpinfiore returns to Carpi. In the large and picturesque Piazza dei Martiri, in the shadow of the Palazzo dei Pio
floriculturists from all over Italy will meet to exhibit their production of many varieties and types of plants
On Saturday 3 and Sunday 4 May 2025, the beautiful gardens of Villa Pallavicino in Busseto will host Ortocolto
a market festival of floricultural biodiversity
where you can find selected botanical varieties
but also the creations of artisans and artists and many typical agri-food products of local biodiversity
You can also take the opportunity to visit the Renata Tebaldi Museum
with a fascinating multimedia itinerary on the heritage of Italian melodrama
On Saturday 3 and Sunday 4 May 2025, the gardens of Villa Braghieri in Castel San Giovanni
on the border between the provinces of Piacenza and Pavia
a traditional exhibition and market dedicated to flowers
There will be special areas for children with workshops and themed games
while adults can take part in guided tours inside the villa
On Saturday 17 and Sunday 18 May 2025, Santarcangelo di Romagna
will host the traditional Balconi Fioriti (Balconies in Bloom) festival
Social Media Manager for @inEmiliaRomagna and full-time mom
by Elisa Mazzini /// March 11
by Daniela Camboni /// March 18
by Davide Marino /// March 30
an email (in Italian) with selected contents and upcoming events
i am looking for a map and any other info you can provide on Dante’s walk
For information, contact us: inemiliaromagna@aptservizi.com
Guido Guastalla, an Italian historian, has filed a legal complaint to police over the exhibiting of a portrait of Pablo Picasso attributed to Amedeo Modigliani at the exhibition of the Italian painter’s work at the Albertina museum.
Allegedly painted by Modigliani in 1915, the work borrows Picasso’s Cubist style but is a forgery, claims Guastalla, who says that the respective daughters of Modigliani and Picasso have also respectively doubted its authenticity.
The work is on display at the Albertina museum in ViennaALAMYGuastalla’s complaint, quoted by Italy’s Corriere della Sera, also raises suspicions about another four works at the exhibition, claiming they lack documentation proving their authenticity and
Metrics details
This article has been updated
The taxanes paclitaxel and docetaxel show good activity in the management of advanced ovarian cancer when used in conjunction with platinum agents
Accumulating evidence from clinical studies
particularly the latest results from the phase III comparative SCOTROC study
indicates that the two drugs confer similar rates of tumour response and survival in women with this condition
it is clear that paclitaxel and docetaxel differ in their tolerability profiles and in other respects
and cannot be regarded as directly equivalent drugs
paclitaxel is associated with significant neurotoxicity; peripheral neuropathy has also been reported with docetaxel
Neutropenia appears more prevalent with docetaxel than with paclitaxel
although clinical trial data show that this adverse effect is manageable and need not compromise dose delivery
Docetaxel is also associated with potential benefits accruing from shorter infusion times and lack of need for premedication with intravenous histamine H1 and H2 antagonists
Emerging quality of life data are expected to shed further light on the overall benefit of chemotherapy in women with advanced ovarian cancer in general
and on taxane−platinum combinations in particular
In cases where different drugs show similar survival benefit in advanced malignant disease
issues relating to toxicity and quality of life (QoL) become increasingly important
Current data suggest that the taxanes paclitaxel and docetaxel have similar efficacy
but regimens based on either of these two drugs have shown potentially important differences in their toxicity profiles
As it is always important to balance risks and benefits when setting out treatment plans for individual patients
knowledge of the tolerability differences between the taxanes available is clearly necessary for informed treatment decisions to be made
this article reviews the toxicity profiles of each taxane and discusses QoL issues affecting patients with ovarian cancer
Both docetaxel and paclitaxel are usually administered once every 3 weeks
Most patients with ovarian cancer receive paclitaxel as a 3-h infusion
This shortened infusion time suggests a potential advantage in terms of patient convenience and other factors such as clinic time and resources for docetaxel
A 30% partial response rate was noted in 13 assessable patients
and there was no evidence of cumulative myelosuppression
Myelosuppression was not dose limiting from 20–52 mg m−2 weekly in 35 evaluable patients
Grade III leucopenia was noted in 14% of the patients
and there were no reports of grade IV leucopenia or grade III or IV thrombocytopenia or anaemia
An overall objective response rate of 25% was achieved in this phase II study
and peripheral neuropathy of grade 2 severity or greater was observed in seven patients (13%) of whom four withdrew from the study
patients who receive paclitaxel require both intravenous histamine H1 and H2 antagonists in addition to oral corticosteroids before 1-
although there is some evidence that premedication is not needed before prolonged infusions (those exceeding 96 h)
the premedication regimen recommended for patients receiving docetaxel consists of 3 days' oral dexamethasone (8 mg twice daily)
A 5-day premedication was originally recommended for patients being treated with docetaxel
but this was subsequently reduced to 3 days after the latter regimen was shown to be associated with similar rates of fluid retention and less mucositis and infection
In almost all patients receiving paclitaxel
white cell counts begin to fall 5–7 days after administration
with a nadir being reached between day 7 and day 14
This phenomenon is seen earlier in docetaxel recipients: white cell counts start to fall 4–6 days after administration
and a nadir is reached between day 6 and day 8
A higher proportion of patients in the docetaxel arm than in the paclitaxel arm experienced grade IV neutropenia (80 vs 55%)
although this was reported by the authors not to have compromised dose delivery or patient safety
guidelines are in place to aid clinicians in the use of colony-stimulating factors in patients likely to be at risk of myelosuppression
and appropriate treatment of this type would be expected to minimise the incidence and severity of neutropenia in patients receiving docetaxel with carboplatin in future studies
who showed no grade IV leucopenia in their study of weekly docetaxel in 35 patients with advanced ovarian cancer
This suggests that weekly schedules of docetaxel may offer a clinical alternative for the minimisation of myelosuppression
Patients were randomly assigned to receive (i) paclitaxel 175 mg m−2 over 3 h followed by cisplatin 75 mg m−2 or (ii) cyclophosphamide 750 mg m−2 followed by cisplatin 75 mg m−2 for six to nine cycles
28% of patients who received carboplatin with paclitaxel (n=400) compared with 31% in the cisplatin–paclitaxel arm (n=392) were affected by grade II–IV neurotoxicity
Chemotherapy was given for up to six cycles as first-line treatment in women with grade Ic–IV ovarian cancer
Patient numbers denote those available for assessment of each adverse event shown
Although this adverse effect can have significant effects on body image
it does not pose any clinical risk to the patient
the goals of chemotherapy in advanced cancer should include improvement in QoL as well as increased duration of survival
Quality of life is therefore assuming ever-greater importance in the evaluation of cancer treatments
a clinically superior treatment may be so poorly tolerated that any survival advantage gained may not be sufficient to offset losses in QoL
Most generic QoL tools do not adequately capture disease-specific information or address treatment-related issues relevant to women with ovarian cancer
but the EORTC has recently developed an instrument specifically to deal with this problem
this review was published before the development and introduction of the OV28 module
despite the inability of any instrument available to date to measure chemotherapy-related QoL directly
the lack of any comparative QoL data specific to patients receiving taxane therapy has resulted in considerable interest in the publication of the final analyses of the SCOTROC results
and reported significant psychological distress (expressed as 1.5 s.d
above a predetermined nationwide community sample standard in Mental Health Inventory psychological distress scores) in one-third of patients at study entry
impaired physical functioning was the most important predictor of heightened psychological distress
Clinically significant depression and anxiety
assessed with the Center for Epidemiologic Studies Depression scale (CES-D) and State Anxiety subscale of the Spielberger State-Trait Anxiety Inventory
were found to be more prevalent than had been expected
Clinical depression was shown in 21% of patients
while 29% scored above the 75th percentile for anxiety
Further studies of screening and treatment of psychological distress were recommended to improve QoL outcomes in women with ovarian cancer
Analysis of EORTC QLQ-C30 questionnaire responses from these patients was used to relate biomedical variables to QoL outcomes and to compare patients receiving cisplatin as first-line therapy with those receiving palliative carboplatin for recurrent disease
Women receiving first-line cisplatin reported more appetite disturbance
diarrhoea and nausea than those on palliative carboplatin
QoL declined over time in the newly diagnosed patients
whereas improvements were noted in those with recurrent disease
and lower QoL was found to predict death within 12 months of starting treatment
It was concluded on the basis of these results that the EORTC QLQ-C30 instrument can be used to test clinical assumptions and to influence treatment programmes in women with ovarian cancer undergoing chemotherapy
the findings appear to support the use of carboplatin as a palliative agent in advanced disease
They also indicate the potential utility of structured QoL assessments before clinic appointments as a means of improving overall patient care
Despite similarities in chemical structure and mode of action
docetaxel and paclitaxel cannot be regarded as having the same properties when used clinically
Study results have shown that the substitution of docetaxel for paclitaxel in a platinum-based doublet does not compromise efficacy
but that such substitution may confer benefits in terms of convenience to patients and toxicity
The reduced infusion time generally used with docetaxel (1 rather than 3 h)
together with the need for premedication with oral dexamethasone only
is likely to be more convenient and to reduce the stress placed on patients by their treatment relative to paclitaxel
Docetaxel’carboplatin has also been associated with reduced frequency and severity of neurotoxicity relative to paclitaxel/carboplatin in clinical studies in patients with ovarian cancer
Higher incidences of neutropenia have been reported in patients receiving the docetaxel combination
but this is reported to be easily managed and is not associated with increases in rates of treatment discontinuation or death
There are currently few data relevant to QoL in patients receiving taxane–platinum combinations for ovarian cancer
and QoL instruments cannot measure directly chemotherapy-related adverse effects
the need for meaningful QoL assessments and the subsequent implications for treatment plans have become clear over the past decade
and results gained with the instruments available in comparative trials are awaited with interest
Familiarity of clinicians with differences between regimens in terms of toxicity
dosage and administration and QoL issues as data emerge and accumulate will assist in the optimisation of treatment decisions in patients with ovarian cancer
This paper was modified 12 months after initial publication to switch to Creative Commons licence terms
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The four is the Guastalla string quartet and the three, the jazz trio led by pianist and composer Kate Williams
As the daughter of the great classical guitarist
she was brought up in a world where boundaries between musical genres were always fluid
There is nothing forced or stilted in the combination
The trio plays with genuine swing; the quartet freely deploys its own natural dynamics
Of all the jazz-classical blends I have heard recently this is certainly the most convincing and enjoyable
And Kate Williams is a very good jazz pianist anyway – crisp
incisive and totally at one with the rhythmic ebb and flow
This is the archive of The Observer up until 21/04/2025
The Observer is now owned and operated by Tortoise Media
Andrew Day has helped the company level up in the gaming industry
SITTING IN A meeting room inside Keywords Studios’ Dublin HQ
Andrew Day ponders how an indigenous Irish tech company with a market cap of more than €1 billion can still fly under the radar
still a lot of people don’t know us as an Irish business
We don’t spend a lot of time talking about ourselves either
quietly getting on with our work,” he says
Quietly getting on with his work has proved a successful formula for Day
a nominee in this year’s EY Entrepreneur Of The Year awards
aside from strong organic growth the South African has also overseen the company’s flotation on London’s AIM market in 2013 and more than 30 acquisition deals – the latest of which was announced earlier this week with more set to follow
Having started out providing translation services to tech companies such as Microsoft
the company now provides a range of services – spanning everything from testing
to audio and more recently game development services – as it strives to become the go-to provider of technical services for the great and good of video gaming
From a small operation of around 50 staff when he took over
Day says that Keywords now has more than 6,000 people “on the payroll” – who are spread across more than 50 operational studios
located across 20 countries and on four continents
The company’s revenues were up by 66% to €250 million in 2018
as it reported adjusted profit before tax of €37.9 million
With its headquarters tucked away at the back of an industrial estate in south Dublin
Keywords might not quite be a household name
but its clients certainly are – including blue chip players such as Google
Day admits he was initially a little “reluctant” to take the job of chief executive
The business was originally founded in 1999 when Giorgio Guastalla moved to Dublin to work with his partner
on a language translation and localisation business for software
had worked with Guastalla previously at Brent International and watched closely as the business grew organically
“I know the business since it was started and actually spent a little bit of time helping Georgio position it in the video-game space around 2005
Georigo had been asking me to come and run it for a long time
Eventually I succumbed to Georgio’s charms and did a deal in terms of sharing equity
Following a first period of being in a “very organic
“I thought I had a clear idea of what was going on in the video games industry
It was a bit odd that you had a company the size of Keywords as a key provider
In the early years Day set about expanding both in scale and scope – adding international offices and new service areas such as audio and functional testing
with my backpack moving from Starbucks to Starbucks to grab some free wifi,” he says
Day had also spotted that a fragmented industry could prove a bountiful hunting ground for acquisitions
how are these big companies going to be able to outsource more strategically if they have to deal with hundreds of businesses
so I thought there must be some opportunity for acquisition to accelerate.”
he took an opportunity to move to London and work for Britannia Security Group where he learned the ropes of the merger and acquisition market “at the hands of a master” as the company did 20 acquisitions in around 18 months in the late 1980s
It was an experience that would prove formative as Day put in place Keywords’ growth plan
The company floated on AIM in London in 2013
and since then has embarked on an acquisition spree – with its four deals to date this year taking the running total to more than 30
“The idea was always that we wouldn’t just do this organically
the reason we floated was so we could go out and make acquisitions,” he says
“Those acquisitions were planned to give us a wider range of services to fill in some of the gaps we had and also to give us the geographic footprint we wanted
It is a bit of an accelerator for our business.”
Day says that Keywords has no plans to slow down anytime soon
“There is a very active pipeline of acquisitions
On the one hand we have strong organic growth
and then acquisitions to come on top,” he says
The deal-flow and increasing geographic spread means that Day
has to deal with more than his fair share of travelling
He is recently back from a trip to Asia and is in Dublin for a short stay before flying to Britain on the evening that he meets Fora
I would much rather be travelling than not,” he says
Keywords has grown through a period of flux within the gaming industry
In the past decade the company spotted the trend of the big studios moving to focus their efforts on large pillar blockbuster titles
In the past six or seven years Day has also noted the increasing longevity of games
as additional downloadable content has kept gamers interested in titles for significantly longer
Keywords and Day are in the thick of another shift as massive players such as Google
and Apple are looking to get a share of the market
“What has been validated over the years is that
as a trusted provider of services to the industry
When the industry goes to streaming they take Keywords with it
We are working with Google and others in the space to help them get their services up off the ground,” Day says
Day also has designs on broadening Keywords’ reach
“It is an area of the strategy that we articulated at the time of our IPO in 2013
when we said we will step out into neighbouring areas
You can’t help (but) see the similarities in what we do for video games in film and television
where they are using a lot of the same technology,” he says
“I hope we can carry on doing what we are doing
Our plan is to get to the point where these big clients of ours would feel comfortable in offloading big chunks of what they are currently doing internally to a company like us,” he says
“I would like to think that we are not more than a few years away
and would very much like to steer the business to that and hopefully beyond,” he says
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2025 Fora All Rights Reserved
After being taken as a prisoner of war during World War I
Campigli served as a foreign correspondent in Paris in 1919 before …
The Sunday TimesWhen Keywords Studios went public on London’s junior Aim market in July 2013
the company was valued at just shy of £50 million
raising £28 million in its initial public offering
hailing the participation of blue chip institutional investors as a validation of the company’s growth story
Yet even Day might have found it hard to imagine where Keywords would be 11 years later
The company’s pitch to investors back in 2013 was that it would play a leading role in the consolidation of a highly fragmented games services industry by acquiring complementary businesses
After acquiring more than 60 companies over a decade and achieving a 6 per cent market share, Keywords
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the Italian leader in the sector of electric household appliances
steps up on to the podium of the coveted international awards with two products: the blender of the 1950s’ Line and the free standing cooker with the Victoria aesthetic
winning the title Red Dot for high design quality
has its value recognized not only as a small household appliance but also as an instrument and contemporary object with an attractive and unmistakable design by Matteo Bazzicalupo and Raffaella Mangiarotti of Deepdesign©
the Smeg blender combines performances of high technology with a design characterized by its sinuous shapes and vintage colours
The models of the free standing Victoria cooker were awarded the Red Dot: Best of the Best: 110 cm wide
they capture perfectly the essence of a classic and timeless aesthetic
emancipating it from the past through the contemporary language of the notes of colour
Equipment for real connoisseurs of cooking
they have a series of accessories for specific functions: the great attention to details
such as the 1950s’ style Smeg logo on the upstand and the chrome knobs exalt the distinctive and unique design of this household appliance
More than 5,200 products from companies and designers coming from over 57 countries took part of this edition of the Red Dot design Award
organized for the first time in 1955 by the Design Zentrum Nordrhein Westfalen in Essen
The Smeg products met all the criteria of evaluation of the select jury of the Red Dot Award: degree of innovation
ecological compatibility and symbolic and emotional contents
the BLF01 blender and the free standing Victoria TR4110 cooker
will be presented at the special exhibition “Design on Stage” for four weeks
before joining the permanent collection of the Red Dot Design Museum in Essen
one of the largest Italian home appliance companies
was founded in 1948 by a family of entrepreneurs who
managed to develop a strong and growing company
Smeg is run by the third generation of Bertazzoni
but it still keeps the memory of its beginnings alive in its name
an acronym for Smalterie Metallurgiche Emiliane Guastalla ("Emilian metallurgical enamel works of Guastalla")
the brand has established itself as a symbol of high aesthetic and technological appliances
made with a unique attention to research and development of exclusive products
Each new appliance is for the SMEG a special artifact
which arises from a deep study of shapes design
which carries out painstaking research into aesthetics and style
has the support of internationally renowned architects such as Guido Canali
Matteo Bazzicalupo and Raffaella Mangiarotti
Today Smeg has a strong international presence with 18 direct commercial subsidiaries (France
and a large network of distribution partners all over the world
If you're tired of boring kitchen appliances
Companies like Bertazzoni, Ilve, and function ga4_link74() { window.dataLayer.push(JSON.parse('{"event":"default_event"}')) }Fulgor are importing some of the most interesting appliances on sale in the US
Whether you're looking for retro looks or modern design
there's an Italian manufacturer with a product to match
That not-very-Italian name is actually an acronym for the very Italian-sounding Smalterie Metallurgiche Emiliane Guastalla
which translates roughly to "Guastalla metal enamel factory."
Founded in 1948 by a branch of the Bertazzoni family
it's grown into a major appliance manufacturer in Italy
Nobody else makes refrigerators based on function ga4_link75() { window.dataLayer.push(JSON.parse('{"event":"default_event"}')) }vintage Fiat cars
cooktops designed by world-renowned architect Renzo Piano
you can find Smeg appliances in specialty appliance retailers or online
And they're surprisingly affordable for high-end products
Freestanding gas ranges sell for around $3,000
which is less than what a similar Viking or Wolf would cost
And built-in cooktops and wall ovens might set you back slightly more than a comparable KitchenAid or Electrolux
We caught up with Smeg CEO Vittorio Bertazzoni
at the Architectural Digest show in New York
He showed off some of Smeg's latest products
including a retro fridge emblazoned with the Italian flag
But when it comes to attractive Italian appliances
Ilve (pronounced "ill-vay") sells a unique range with a convertible burner in the middle
owned by a branch of the same family that started Smeg
It's got a series of wall ovens with solid glass handles
and line of sleek wall ovens and cooktops for small kitchens
Bertazzoni also sells a unique line of ranges that can be finished in any color—they're painted in Modena alongside Ferrari's supercars
We bet your oven doesn't have that kind of pedigree
Prices were accurate at the time this article was published but may change over time
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“What I like most about my job is following a new product through every stage in its development
from creation and design to production and sale,” says Vittorio Bertazzoni
the company famous for home appliances so stylish its motto is “Tecnologia che arreda”
The acronym Smeg stands for Smalterie Metallurgiche Emiliane Guastalla: the Emilian enamel works of Guastalla
The latter is a small town near Parma; Emilia is the northern Italian region in which it lies
Today the company’s headquarters are at San Girolamo
It’s here that Bertazzoni and I meet
in a sleek one-storey office building designed by architect Guido Canali
tucked away among greenery on an man-made lake
“The idea was to create harmony between architecture and nature,” says Bertazzoni
He’s dressed like a contemporary captain of industry – navy-blue jacket
tan corduroy trousers – but his blue eyes
framed by longish light-brown hair and a beard
and lofty physique give him the air of a friendly Viking
He’s a busy man who spends a lot of time between offices and aeroplanes
but he obviously finds ways of keeping in trim
I adore going sailing at Porto Venere in Liguria
joined the Smeg board as a slip of a youth in 1998 and was appointed CEO in 2007
he graduated in law at the University of Parma
and then studied comparative labour law at St Peter’s College
To gain work experience he did a two-year stint at Arthur Andersen
after which he returned to Italy for a year at the Mediobanca investment bank in Milan. Bertazzoni is proud of his roots
“We Emilians are very industrious people
We’re known for our engineering and our food
Even before the last war we were manufacturing planes and cars.”
“And we’ve been producing Parmigiano- Reggiano cheese for a thousand years
Then there’s prosciutto di Parma.”
“And culatello and stuffed pasta,” he says
By channelling its manufacturing know how into the kitchen in the form of cookers
Smeg embodies both of the region’s vocations
Not to mention the fact that Bertazzoni’s family also produces superb Parmigiano-Reggiano at their dairy farm in the foothills of the Apennines
Much of the three-hour drive down to Guastalla from Turin has taken me along the deceptively named Po Valley
actually a vast floodplain of numbing flatness
exhibition centres and industrial parks that impede any view of the countryside
it’s hard to imagine this is Italy’s agricultural heartland
I know that beyond the industrial clutter are fertile fields stretching to the horizon
Ikea – speak of an invasion by multinationals
“The company was founded by my grandfather Vittorio
‘Those must have been tough years,” I muse
But there was also a desire to start afresh
In the 1930s Nonno Vittorio had been a stovemaker
He brought all his experience to bear in the new endeavour
In the 1950s the company produced mainly cookers.”
“The years of the famous ‘economic miracle’
People had money to spend and there was a big demand for household appliances
But the products companies were commercialising were virtually identical
He was the first in the sector to collaborate with great architects and designers to produce kitchen appliances that were also timeless objets d’art
Everyone loves the idea of Italian lifestyle
Italian design is ultimately the fruit of thousands of years of art and culture
Growing up among the marvels of Parma as I did
a certain amount of artistic sensibility is bound to rub off on you.”
where I’d popped in to have a look around on my way to Smeg’s head office
it was ruled by the Gonzaga family of Mantua
and they had built the Palazzo Ducale and the Municipio on the pretty
On the same piazza there’s also a Renaissance cathedral with an imposing Baroque façade
Unfortunately it was impossible to go in – restoration work was still under way after the damage caused by an earthquake in 2012
The artistic sensibility Bertazzoni speaks of is also evident in the foyer of the Smeg office building
Michael van Ofen and Ray Smith adorn the walls
including one of Arnaldo Pomodoro’s signature exploding globes
There’s also a permanent display that charts a timeline of Smeg production: vintage cookers (very popular with Russian customers apparently)
bombé retro Fab fridges in a multitude of colours and designs (the Italian tricolore
the jerseys of miscellaneous soccer and rugby teams) and striking new stoves on which little birds and leaves and fruit and butterflies replace conventional surface elements
“It’s a new line I’ve called Dolce Stil Nuovo
I enjoy literary references,” he says
was coined by Dante in the 13th century to defi ne a new poetic genre
“It has that unique touch of folly so typical of Italian design,” says Bertazzoni
“Instead of a cooktop you have a work of art.”
The same can be said of the Smeg fridge installed in the engine compartment of a Fiat 500
The project brought me into contact with [Fiat heir apparent] Lapo Elkann
He subsequently came up with the idea for Independent Fab
Dolce & Gabbana has joined forces with Smeg to produce a limited-edition series of brilliantly coloured fridges that evoke the Sicilian puppet-theatre tradition
which is also the leitmotif of their 2016 summer collection
“We intend to develop our ’50s Retro Style line of small appliances: toasters
“I think the present-day passion for healthy eating and cooking is a good thing
Even TV shows like MasterChef have a part to play
making people more creative in the kitchen and more attentive to quality
and I’m happy if our products help them to make healthy dishes.”
we’re also branching out into wine coolers.”
It has three plants in Italy and a diff use global presence with 20 subsidiaries in as many countries
The company sells 80 per cent of its products abroad and is currently expanding in Mexico and Turkey
“Istanbul is my favourite city after Rome,” says Bertazzoni
As he approaches his 10th year in the hot seat
what does he regard as his greatest achievement so far
“The fact that I’ve always managed to stay faithful to our corporate philosophy
I became CEO on the eve of the financial crisis
which was profounder here in Italy than elsewhere
we’ve kept all our production at our three plants in Italy
end consumers across the world have rewarded us for the quality and creativity of our products
They say that necessity is the mother of invention
we Italians are more inventive than most.”
smeg.com.au
NEWS|Art Photo Design|La grande transizione
you can make out the noble virtues of the modern woman in Milan
Samurai were the soldiers of feudal Japan: they belonged to an educated
aristocratic caste of warriors and practised the martial arts.History says that they were courageous and had a free spirit
and that they served honour and valour before all else
It was a memorable opening thanks also the presence of a large number of guests
Andrea Buccellati and Giuliana Parabiago and some of the women themselves
Maria Buccellati and Christina Estrada Juffali.Of the thirty photographs created
twenty have been put on show (until 12 November)
with a backdrop of intense colour and mounted on aluminium
the images present a tone by tone histogram representing the noble virtues that the artist perceived in each of the women
symbolic dresses with extensive attention paid to the details
the talented Vecchiarelli has given a name with Asian origins
and She Who Governs the Flow of the Waters.They are women of undeniable beauty
warriors who encourage humanity with strength
energy and heart to recreate a balance between the different spheres of existence
La Grande Transizione by Leonardo Vecchiarelli11 October - 12 November 2011Studio Guastalla, 24 Via SenatoMilanwww.guastalla.com
Vittoria Mentasti's Dead Sea takes us to a place where the sky and the sea are one
A chat with Kristin Prim, the founder of The Provocateur, the site that publishes letters written expressely by leading women addressing the whole female world. Vogue.it presents you an exclusive preview of the letter written by Dresden Dolls' Amanda Palmer
During the Yeezy Season 3 fashion show, Kanye West presented his new album, The Life of Pablo. Here's everything you need to know (and let's get ready to the fight with Taylor Swift)
The most exclusive parties at the New York Fashion Week
All the best street style spotted at New York Fashion Week
From New York Fashion Week Fall Winter 2016/17
Menswear and womenswear collections will walk together and will be on sale right after the show. These are the news from Burberry but the evolution is generalized: runway shows are changing
The documentary that celebrates 3.1 Phillip Lim's tenth anniversary
The latest social media initiatives dedicated to the Fashion world
The (Perfumes) Factory
The world of the ancient Japanese warriors in a book and an exhibition
- P.zza Castello 27 - 20121 Milano cap.soc
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